The Ohio State University Medical Center

Department of Otolaryngology —Head and Neck Surgery

Winter 2010

Dear Friends and Colleagues,

It has been a banner year at The Ohio State University Department of Otolaryngology.We completed the new Ohio State Eye and Ear Institute and moved in the end of June(see inside photo). This new facility gives our patients easy access from two freewaysand free surface parking. They love it. So do we. The building houses an ambulatorysurgery center, a 13-station temporal bone and sinus laboratory and a beautiful con-ference center. Please stop by and see it when you are in town.

Our new laboratory space at the Eye and Ear Institute has allowed us to recruit fournew researchers to the Department under the guidance of Susan Nittrouer, PhD, in theCommunications Sciences Research Laboratory. Jeffrey Marler, PhD, Antoine Shahin, PhD, Bomjun Kwon,PhD, and PuisanWong, PhD, have been getting their labs established and will make a difference in the wayhearing impaired children acquire language. You can view their biographies in this newsletter. We are pleasedto have them on our team and eagerly anticipate the research that will emanate from this group.

We are also fortunate to welcome four new clinician scientists this year. Eugene Chio, MD, Bradley Otto, MD,Garth Essig Jr., MD, and Matthew Old, MD, have been busy establishing their research and patient careactivities. Dr. Chio’s interests lie in medical and surgical aspects of sleep apnea and general otolaryngology.Dr. Otto just completed a two-year NIH-funded fellowship in Dr. Sally Wenzel’s laboratory at the University ofPittsburgh Medical Center, studying the effects of cytokines on nasal polyposis while doing a rhinology fellow-ship. Dr. Essig completed his residency at the University of Virginia, and an endocrine and cutaneous cancerfellowship in Brisbane, Australia. Dr. Old completed his residency at the University of Michigan, and a headand neck fellowship with James Netterville, MD, at Vanderbilt University. We are delighted to have these newdoctors on board.

Our faculty and staff are focused on providing the best patient care available. We maintain our commitmentto research and teaching because, ultimately, it’s what leads to the best patient care. We have many excitingchallenges and opportunities ahead, and will use them to the best of our advantage as we strive to improve.

Stop by and see us, and Go Bucks!

D. Bradley Welling, MD, PhD, FACS

Professor and ChairDepartment of OtolaryngologyThe Ohio State UniversityEye and Ear Institute915 Olentangy River Rd., 4th FloorColumbus, OH 43212(614)-293-8706 office(614)-293-7292 faxbrad.welling@osumc.edu

Inside this Issue: Eye and Ear Institute Debut, Clinical Trials Active in2008/2009, Otitis Media in Children, Pelotonia Event, NIH ResearchFunding, Match Results, Awards, Publications for 2008/2009

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In July 2009, The Ohio State University Department of Otolaryn-gology – Head and Neck Surgery moved to the new Ohio StateUniversity Eye and Ear Institute, located at 915 Olentangy RiverRoad, just southwest of Medical Center campus. This state-of-the-art, five-story, 137,000-square-foot facility offers an aestheticallypleasing environment for the delivery of comprehensive ear, noseand throat care from the most qualified experts in central Ohio.Designed to guarantee efficient, personalized care in a convenientneighborhood setting, patients will have access to not only ear andeye care, but a variety of Ohio State’s health services, such as Plas-tic Surgery, the Center forWomen’s Health, Hand Center and Out-patient Surgery Center.

From concept to grand opening, Ohio State’s Eye and Ear Institutewas a project over three years in the making, largely spearheadedby D. BradleyWelling, MD, PhD, chair of Otolaryngology, andThomasMauger, MD, chair of Ophthal-mology. The new facility offers stream-lined patient flow and has broughtresearch, patient care and medical edu-cation under one roof, which helps theDepartment maintain even greater focuson theMedical Center’s goal of improv-ing people’s lives through innovation inresearch, education and patient care.

One of the highlights of the facility is theOtolaryngology Anatomy Skills Labora-tory. This lab has been designed for itsspecific purpose from the ground up.The new lab has double-insulated walls,a dedicated ventilation system, custom-built cabinetry, integrated solid-statework surfaces, central water and vacuum,and special drainage systems designed toprevent debris from entering the watersystem. In designing the space, lead

architect Craig Rutkowski (Moody Nolan Inc.), along with GlenRowe fromDaimler, integrated form and function, creating anaesthetically appealing space that draws visitors in. The lab has 12state-of-the-art work stations plus a teaching station, each outfittedwith LCDmonitors, operating microscopes, otologic drills, middleear/mastoid instruments, sinus endoscopy equipments, sinus mi-crodebriders and central video routers. The Department has se-cured generous donations in equipment from corporate partnersMedtronic, Stryker, OsteoSolutions-Anspach, and Zeiss. The De-partment will use this facility to host regional as well as nationalOtology/Neurotology, Rhinology, Facial Plastic and Facial Traumacourses in the near future.

Tomake a donation to the Department’s education mission, pleasecontactMark Inman at 614-293-3470 orMark.Inman@osumc.edu.

EyeandEarInstitute

The Ohio State University Medical Center Department of Otolaryngology page 2

Eye and Ear Institute Debut

Nationally RankedOhio State University Department of Otolaryngology Ranked asOne of the Best in Nation

For the 17th year in a row, U.S.News &World Report ranked Ohio State’s Department ofOtolaryngology as one of the best ear, nose and throat programs in the nation. The rankingsare based on discharges, resident’s scores on national tests and reputation. Our Departmentadvanced 13 positions in the rankings this year to No. 18 in the country – an outstandingachievement. The Ohio State University Medical Center was also named to the U.S. NewsHonor Roll for the first time ever. Of the 4,861 hospitals considered, only 21 made the HonorRoll, and Ohio State was the only hospital in central Ohio to make the list. Our hospitals wereranked in 10 specialties, and our ranking of 18th helped the Medical Center achieve thishighly touted accomplishment.

PI Division Title

David Schuller, MD Head and Neck Oncology Incorporation of Intensity Modulated Radiotherapy andSubmandibular Gland Transfers to Minimize TreatmentMorbidity (pending)

Amit Agrawal, MD Head and Neck Oncology A Phase lb Pilot Study Evaluating Oral Administration of Freeze-Dried Black Raspberries in Pre-Surgical Patients with OralSquamous Cell Carcinoma (open)CPAP.”

Amit Agrawal, MD Head and Neck Oncology A Pilot Study Evaluating Long-Term Oral Administration ofFreeze-Dried Black Raspberries in Post-Surgical AppalachianOral Cancer Patients

Amit Agrawal, MD Head and Neck Oncology Chemoprevention of Oral Cancer in Appalachia

Amit Agrawal, MD Head and Neck Oncology A Randomized, Prospective, Controlled Study of Donor SiteHealing When Using a Negative Pressure Dressing for RadialForearm Free Flaps.

BradWelling, MD, PhD Otology, Neurotology, Delayed Facial Nerve Paresis after Vestibular SchwannomaCranial Base Surgery Resection: A Randomized Prospective Trial Evaluating

Prophylactic Antiviral and Steroid Therapy

Abraham Jacob, MD Otology, Neurotology, Mastoidectomy Defect Reconstruction with Lactosorb andCranial Base Surgery TitaniumMesh

Abraham Jacob, MD Otology, Neurotology, Translabyrinthine Craniotomy Defect Reconstruction withCranial Base Surgery Lactosorb Plating

Abraham Jacob, MD Otology, Neurotology, Factors Predicting the Response of Melatonin on TinnitusCranial Base Surgery

Abraham Jacob, MD Otology, Neurotology, Effectiveness of OtoMimix™ Hydroxyapatite Bone CementCranial Base Surgery Ossicular Chain Reconstruction for Otosclerosis and

Incudostapedial Joint Separation

Charles Albert Pediatric Otolaryngology Incidence of Vestibular Stenosis in NICU Patients on Nasal CPAPElmaraghy, MD

BradWelling, MD, PhD Otology Determination of Intratumoral Concentration of Lapatinib inVestibular Schwanoma Therapy

BradWelling, MD, PhD Otology Hybriel Cochlear Implant L24 Study.

Clinical Trials Active in 2008/2009ClinicalTrials

For more information on the Department’s clinical trials, contact: Mark Inman915 Olentangy River RoadPhone: 614-293-3470

The Ohio State University Medical Center Department of Otolaryngology page 3

The Ohio State University Medical Center Department of Otolaryngology page 4

Does complement system play a significant role in middle ear defenseto eliminate the otopathogens during Otitis Media?

Streptococcus pneumoniae (S. pneumoniae) is one of the majorpathogens of otitis media (OM) (middle ear inflammation) inchildren, accounting for 30 percent of the cases of acute OM and5 percent of the cases of chronic OM with effusion (OME). Whilethe course of OME, a chronic nonsuppurative form of the disease,is generally benign and self-limiting, hearing loss caused by thepresence of fluid in the middle ear space for an extended periodof time can affect a child’s language development and educationduring a highly critical period. Despite advances that have beenmade in S. pneumoniae OM research in the last decade, muchmore remains to be learned about how S. pneumoniae interactswith the host innate immune defense systems and becomesestablished in middle ear and induces OM.

Complement system is one the front lines of host innate immunedefense system against infection. Clinical observations andexperimental studies suggest that the complement system plays

a significant role inmiddle ear defenseto eliminate theotopathogens dur-ing OM. However,the relevance ofcomplement com-ponents and thespecific pathway ofthe complementcascades involved inthe protection dur-ing S. pneumoniae

OM remain largely unknown. We have assessed the role ofspecific complement activation pathways (classical or alternativepathway, or both) in the middle ear defense against S. pneumo-niae invasion. We compared bacterial clearance kinetics, middle

ear inflammation, S. pneumoniae opsonisation, and opsonophago-cytosis, and cytokine and chemokine production in C1qa knockout (KO) (lack of the classical pathway), Factor B (Bf) KO (lack ofthe alternative pathway), and Bf and C2 double KO mice (lack ofall three pathways) to that in wild-type (WT) mice in a mousemodel of OM. Our data demonstrated C1qa and Bf are both im-portant in the protection against pneumococcal OM. Further-more, Bf/C2 deficiency significantly increases susceptibility topnoumococcal OM beyond that in either C1qa-/- or Bf-/- mice.We further investigated the mechanism of complement resistantbacteria to survive in the middle ear. We compared inflammatorycell recruitments in the middle ear of all the cohorts studied dur-ing the early stage of AOM, Our data revealed increased inflam-matory cell concentrations in the middle ear lavage samples inboth wild-type and complement deficient mice, which indicatedthat the recruitment of inflammatory cells was not impaired inthe complement deficient mice. The influx of inflammatory cellsmay be driven by the cytokines IL-6, IL-1 and TNFα and S. pneu-moniae replication in the middle ears, as our data showed the in-creased level of these cytokines in the middle ear lavage samplesin complement deficient mice compared to wild -type mice. Fur-thermore, we demonstrated that both in vivo and in vitro C3binding to S. pneumoniae surface in the middle ear and blood wasgreatly reduced in complement deficient mice compared to thewild-type mice. Our data suggest that an intact complementpathway is critical to otological innate immune defense againstS. pneumoniae. In addition, the reduced capacity of complementmediated opsonization and opsonophagocytosis in complementdeficient mice contributed at a significant level to the impairedS. pneumoniae clearance from the middle ear. An abstract tilted“Role of complement C1q, C2 and factor B in innate immunityagainst Streptococcus pneumoniae during experimental acute otitismedia in mice” was presented at the 6th Extraordinary Interna-tional Symposium on Recent Advances in Otitis Media on May 6-10, 2009, in Seoul, Korea.

After five years of NIH funded research, Susan Nittrouer, PhD,has published Early Development of Children with Hearing Loss,with Plural Publishing. In this book, she discusses hearing lossand speech development and her findings on hearing aids,cochlear implants and language development. Currently, she andher research team are recruiting subjects for studies funded byher NIH grant, “The Ontogeny of Segmental Speech Organiza-tion.” The aim of this grant is to explore the development ofphonological abilities in normal children, and what may go wrongin this process for children at risk for language problems. Re-search under this grant focuses on how children discover:

• how to organize the sensory input in order to recover linguisti-cally meaningful structure at a global level

• which acoustic properties support phonetic structure in theirnative language

• how each property should be weighted in speech perception inorder to efficiently apprehend that structure.

Please check out their Web site at http://www.speechdevelop-ment.org/osso to find out more information about this study andhttp://www.speechdevelopment.org /edchl for information onher book.

New to the Communication Sciences Research Group:

• Bomjun Kwon, PhD, joins us from the University of Utah, Salt LakeCity. He is investigating the feasibility of new and improved use ofelectrode configurations for speech processing in cochlear implants.

• Jeffrey Marler, PhD, joins us from James Madison University,Harrisonburg, Va. His primary research focus is auditory informa-tion processing associated with language development, specifi-cally sensory, attention and memory mechanisms supportingauditory language processing. His ancillary research area is theinvestigation of genetic factors contributing to hearing sensitivityand auditory function in chromosome 7 disorders.

• Antoine Shahin, PhD, comes to us from the University of Cali-fornia, Davis. His primary research focus is on understanding theneural mechanisms underlying speech and music processingusing functional neuroimaging methods.

• PuisanWong, PhD, has come from Brooklyn College, New York.Her primary research interest is to examine the perception and pro-duction of speech sounds, and how that relates to language develop-ment in normally developing and atypically developing individuals.

We are fortunate to have recruited such promising researchers toour highly respected research group.

OtitisMed

iainChildren

According to the Pelotonia.org website, Pelotonia is a grass-roots bike tour with one goal: to end cancer. Pelotonia raisesmoney for innovative and life-saving cancer research at TheOhio State University Comprehensive Cancer Center –Arthur G. James Cancer Hospital and Richard J. Solove Re-search Institute. Pelotonia directs 100 percent of every dollarraised to research. It is a community of people coming to-gether to chase down cancer and defeat it. Lance Armstrong,Jim Tressel, and Ohio State University Gordon Gee partici-pated in the inaugural Pelotonia event, Aug. 28-30, 2009.

Pelotonia included four different routes:• 180-mile, two-day ride• 100-mile, one-day ride• 50-mile, one-day ride• 25-mile, one-day ride.

The 180-mile ride led the peloton to the city of Athens, where ridersspent the evening atOhioUniversity. Riders fromour faculty included:• Amit Agrawal, MD• Theodoros Teknos, MD• Stephen Smith Jr., MD and his wife, Nevada Smith• David Schuller, MD and his son, Michael• D. Bradley Welling, MD, PhD• Matthew Old, MD• Christin Hart

Several of our staff members also volunteered during the event.Our team members had this to say about the event:

Amit Agrawal, MD“As a head and neck cancer surgeon at The James, I witness firsthandthe devastating effect that cancer has upon my patients and theirfamilies. Despite our many successes, it never becomes easier. It is,however, the tremendous spirit and courage of my patients that moti-vates me to find better ways to treat this disease, specifically throughadvancements in patient care, education and in particular, by beingactively involved in cancer research. Participating in Pelotonia is awonderful opportunity to support research at The James by involvingthe community we serve, and whose warmth and support give per-sonal meaning to our continued efforts to fight this disease.”

Theodoros Teknos, MD“My patients (many of whom become my best friends) inspire medaily with their courage, strength, hope and love. I do my best to helpthem, but I know I need to do more. I rode in Pelotionia in memory ofall of those friends who have lost their battle, and in honor of all ofthose who have triumphed and for a future free from head andneck cancer.”

David Schuller, MD“It has been an honor and privilege in my more than 20 years at OhioState to have served as Director of both the Comprehensive CancerCenter and the James Cancer Hospital and Solove Research Instituteand as the CEO of The James. In my current role on the leadershipteam of ProjectONE, the largest expansion project ever undertaken byOhio State, which will nearly double of the size of the cancer hospital,I’ve had the opportunity to reflect on how critically important thecommunity’s support of our cancer research has been and how,

collectively, we are making a difference with this common anddreaded disease.

All of us at The James, and especially our patients, are appreciative ofthe fine people at NetJets who have provided for the creation of Pelo-tonia and for all of the riders and volunteers whose efforts will help usbecome one of the country’s premier cancer research and patient carefacilities.”

Matthew Old, MD“I am honored to have joined The James and the Head and Neck teamthis summer to embark on a career of caring for cancer patients. Ourlives are shaped by significant events and, unfortunately, cancer tendsto create detours for most of us. About 20 years ago, my grandfatherdeveloped lip cancer. He had it surgically treated, but soon developedbuccal squamous cell carcinoma. After extensive surgery andchemoradiation, he eventually lost his life to angiosarcoma.

I did not realize the impact this had on me until now, as I step into therole that his doctors had as they cared for him in exam rooms and sur-gical suites. He was always strong and caring, making his grandkidslaugh even as he received chemotherapy. It always makes me smile tothink of him, because he always seemed to have a smile on his face. Irode in Pelotonia not only for my grandfather, but also for my past,present and future cancer patients. I hope to influence their lives andfoster the strength, courage and energy needed to fight the battle fora cure.”

Fund raisingOne-hundred percent of the proceeds from Pelotonia go to TheOhio State University Comprehensive Cancer Center – Arthur G.James Cancer Hospital and Richard J. Solove Research Institute.The Midwest’s first and Ohio’s only freestanding cancer hospitaland research institute, Ohio State’s Comprehensive Cancer Cen-ter – James Cancer Hospital and Solove Research Institute is oneof only 40 centers in the United States designated by the Na-tional Cancer Institute as a Comprehensive Cancer Center. TheJames is a national leader in creating and testing new therapiesbased on scientific research, many of which are offered nowhereelse in the world. Please check out pelotonia.org for moreinformation.

Pelotonia Event

The Ohio State University Medical Center Department of Otolaryngology page 5

Peletonia

The Ohio State University Medical Center Department of Otolaryngology page 6

NIH Research Funding

NIH Research Funding

Amit Agrawal, MD 12/01/07-08/30/12 NIH/NCI

ChristopherWeghorst, PhD 09/1999 - 08/2009 R01CA127368Food-Based Modulation of Biomarkers in Human Tissues at High Risk forOral Cancer

Lauren Bakaletz, PhD 09/20/02-08/31/13 NIH RO1

Subinoy Das, MD R01DC05847Antimicrobial Peptides and Innate Immunity in Otitis Media

The goal of this project is investigate the role of innate immunity in otitismedia and identify methods to augment these defense mechanisms in orderto develop a novel approach for the treatment and/or prevention of otitis media.

Lauren Bakaletz, PhD 01/01/04-12/31/10 R01DC006468

Joan Durbin, MD, PhD R01DC006468RSV Upper Airway Infection and Otitis Media

The goal of this project is to explore the mechanism of protection as well asthe ability of a recently developed RSV vaccine to inhibit bacterial otitis mediafollowing viral and bacterial co-infection.

Lauren Bakaletz, PhD 09/30/99-08/31/09 NIH RO1R01DC003915Determinants of H. influenzae Virulence in Otitis Media

The goal of this project is to continue to enhance our understanding ofnontypeable Haemophilus influenzae pathogenesis in otitis media as well ascontinue to identify and characterize putative virulence determinants andassess their potential as vaccine or therapeutic targets.

Lauren Bakaletz, PhD 4/01/06-3/31/09 NIH/NIDCD

Anthony A. Campagnari, PhD R01DC007153M. catarrhalis pili: Role in colonization and infection

Lauren Bakaletz, PhD 7/17/09-10/15/11 NIH/NIDCDDeterminants of H. influenzae Virulence in Otitis Media Supplement

Subinoy Das, MD 02/01/09-01/31/11 NIHKL2RR025754Improving Patient Care via Proteomics Based, Microbe-Specific Detection ofChronic Rhinosinusitis

The goals of this project are to 1) identify patients with chronic rhinosinusitis(CRS), specifically due to the presence of NTHI biofilms, utilizing a highthroughput proteomics-based assay, and 2) test a priori assay that willpredict the development of CRS in an in vivo chinchilla model. Results fromthis project may lead to the development of biomarkers to be used as clinicaldiagnostic tools to diagnose CRS at very early stages of disease progression,and aid in the development non-surgical therapies for CRS.

Abraham Jacob, MD 08/01/09-08/01/14 NIH/NCI1K08DC009644-01A1Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma

Vestibular schwannomas (VS), brain tumors arising from the balance nerve,are one of the few deadly diseases of the ear, and patients with VS arecurrently treated with high risk modalities such as surgery and/or radiationtherapy because no effective drugs are available. Our proposal seeks to studyOSU-03012, a new drug that may revolutionize the treatment of VS. We planto better understand how OSU-03012 inhibits VS tumor growth and profile itssafety/efficacy parameters in order to transition this drug into humanclinical trials.

NIH

Research

Fund

ing

NIH Research Funding

The Ohio State University Medical Center Department of Otolaryngology page 7

Bomjun Kwon, PhD 12/01/08-11/30/11 NIH/NIDCRR03DC009061Perceptual effects of mixed channel configurations in cochlear implants

Susan Nittrouer, PhD 09/01/03-08/31/09 NIH/NIDCDR01DC006237Early Development of Children with Hearing Loss

The goal of this project is to investigate outcomes for children with hearingloss as a function of age of identification, whether signs were used in earlyintervention or not, and type of prosthesis.

Susan Nittrouer, PhD 12/01/88-11/30/09 NIH/NIDCDR01DC000633Ontogeny of Segmental Speech Organization

The goal of this project is to investigate how children acquire access tosegmental structure in the speech signal which largely lacks any explicitacoustic structure.

Quintin Pan, PhD 07/01/08-05/31/13 NIH RO1R01CA135069Role of PKCepsilon in Oral Cancer

The goal of this project is to study the biological role of PKCepsilon in the development of metastasis, a recalcitrant challenge in oral squamous cell carcinoma.

Hua Hua Tong, MD 07/01/08-06/30/12 NIH RO1R01DC009235Complement in S. Pneumoniae Otitis Media

The goal of this project is to explore the critical role of complement in themiddle ear in host innate immunity against Streptococcus pneumoniae,a primary pathogen of otitis media.

BradWelling, MD, PhD 05/10/05-04/30/10 NIH RO1R01DC005985Phenotypic Determinants of Vestibular Schwannomas

The goal of this project is to examine the role of regulatory regions in the NF2gene in schwannomas and further identify and understand factors whichaffect phenotypic expression in vestibular schwannomas.

BradWelling, MD, PhD 06/01/09-05/31/10 NIH RO1R01DC005985-05S1Phenotypic Determinants of Vestibular Schwannomas-Supplement

The goal of this project is to examine the role of regulatory regions in the NF2gene in schwannomas and further identify and understand factors whichaffect phenotypic expression in vestibular schwannomas.

GregoryWiet, MD 08/01/04-07/31/09 NIH RO1R01DC06458Validation/Dissemination of Virtual Temporal Bone Dissection

The overall goals of this project are to further develop, evaluate, and validatea virtual environment for training of surgical techniques of temporal bonesurgery by residents.

Quintin Pan, PhD 07/01/08-06/30/11 Flight Attendant Med. Res. Inst. GRT00013551Development of PK-Cepsilon Inhibitors for Treating Head and Neck Cancer

Quintin Pan, PhD 07/01/08-06/30/12 American Cancer SocietyMechanism of PKC-Induced Tumorigenesis in Head and Neck Cancer

Theodoros Teknos, MD 2008-2013 SPORE, Project 1Metronomic Small Molecular Inhibitor of Bcl-2 in Head and Neck Cancer Therapy

ChristopherWeghorst, PhD 07/01/06-06/30/11 American Cancer SocietyAmit Agrawal, MD Chemoprevention of Oral Cancer in Appalachia

NIH

ResearchFunding

The Ohio State University Medical Center Department of Otolaryngology page 8

Match Results

Brian Boyce, MD

Medical College of Georgia

• Born in Atlanta, GA.

• Graduated Magna Cum Laude withHonors from University of Georgia with aBS in Biology

• President of AOA at Medical College ofGeorgia

• Coca-Cola Scholar Athlete (2001)

• Hobbies include: playing the piano, guitar

Lauren Cunningham, MD

GeorgeWashington UniversitySchool of Medicine

• Born in Buffalo, N.Y.

• Graduated from the College of Williamand Mary in 2004, where she was Presi-dent of the Golden Key Honour Society

• At the Virginia Institute of Marine Sci-ence, she assisted in research in a species differentiation studyand gut retention study on Pfiesteria, a major dinoflagellateimplicated in fishkills on the Eastern sea board

• Voted Most Athletic Female in her medical school class

• Personal interests: playing any sport or outdoor activity,playing piano, enjoying wine and cheese, baking and knitting

Anna Marcinow, MD

University of Iowa School ofMedicine

• Born in Wroclaw, Poland and movedto United States at age 10

• Completed her undergraduate educa-tion at Iowa State University, earning aBS with honors and distinction in Bio-chemistry and German

• Participated in 2009 Iowa MOST Cleft Lip and Palate trip inHuehuetenango, Guatemala

• Conducted research involving genetics of cleft lip and palateand quality of life in head and neck cancer patients at theUniversity of Iowa

• Enjoys golf, hiking, reading, Wii, traveling and cooking

Lisa Steketee-Weaver, MD

Indiana University School ofMedicine

• Born in East Grand Rapids, Mich.

• Completed her undergraduate degreeat Colgate University, where she gradu-ated Magna Cum Laude with a major inCellular Neuroscience and was electedto Psi Chi and Phi Eta Sigma National

Honor Societies

• Her husband Tim will be starting a general practice resi-dency in Dentistry at Ohio State

• Received Howard Hughes research grant and participated insix months of research investigating the “mucus slurper” andits utility in preventing nosocomial pneumonia

• Enjoys spending time with family and friends, downhillskiing, running and cooking

Match

Results

Recent GraduatesThis past July, we saw three of our residents and two fellows graduate from our program: Eugene Chio, MD, Alfred FlemingJr., MD, and Kris Jatana, MD. Dr. Chio joined the Department as a full-time faculty member and general otolaryngologist.Dr. Fleming accepted a position in private practice with Ohio ENT and Dr. Jatana will be completing a pediatric fellowshipat Children’s Memorial Hospital in Chicago. Our graduating fellows are Brad deSilva, MD, and MatthewMiller, MD. Weare proud of our graduates and wish them the best of luck.

Once again, we are most pleased to have matched outstanding candidates to our Otolaryngology –Head and Neck Surgery Program here at The Ohio State University. All four are tremendous individ-uals whose cumulative Step 1 USMLE scores are in the 99th percentile. We look forward to greatthings from them through their five years with us and well beyond.

Awards

The Ohio State University Medical Center Department of Otolaryngology page 9

We wish to express our thanks to Ed Dodson, the screening and selection committee, and all who assistedin interviews, tours and other arrangements. We know it is a great investment of time but, as you can see, ithas again yielded a great return on your investment. It looks like we got four blue-chip recruits this year!Thank you all for your help.

We also welcome Neurotology fellowMatthew Bush, MD, and incoming Head and Neck Oncology fellowBradford Bader, MD.

Matthew Bush, MD

University of Kentucky Albert B.Chandler Medical Center

• Born in Charleston, W.V.

• Completed medical school atMarshall University School of Medicine

• Has already completed a one yearresearch fellowship within ourDepartment

• Married, with two sons

• Enjoys medical missions, medical history and golfing

Bradford Bader, MD

University of Michigan HealthSystem

• Born in Dallas, Texas

• Completed medical school atUniversity of Texas Medical School

• Completed undergraduate at South-ern Methodist University, where hegraduated Magna Cum Laude with a

BA in Business Administration and also played Division I soccer

• Married, with one daughter

Abraham Jacob, MD, was recentlyawarded the NIH/NIDCD (K08)Mentored Clinical Scientist Re-search Career Development Award,effective 8/1/2009-8/1/2014. Dr.Jacob started out as a fellow inOhio State’s Neurotology Program(2004-2006), and is currently anassistant professor on the tenuretrack within the Department. This$1.2 million NIH grant, titled: “Pre-clinical testing of a novel PDK1 in-

hibitor for treating vestibular schwannoma,” seeks to betterunderstand how inhibiting intracellular AKT signaling in vestibu-lar schwannomas (VS) suppresses cell cycle progression and ini-tiates apoptosis. Dr. Jacob received the 2007 Nicholas TorokAward from the American Neurotology Society for his workdemonstrating that AKT was pathologically active in VS as com-pared to normal vestibular nerves. Along with several collabora-

tors at Ohio State’s Comprehensive Cancer Center – James Can-cer Hospital and Solove Research Institute, he has recently pub-lished data demonstrating that OSU-03012, a novel smallmolecule inhibitor of AKT, inhibits VS growth in cell culture aswell as in animal models (European Journal of Cancer). OSU-03012 has recently entered Phase I human clinical trials for can-cer and, by further evaluating the mechanism of action, efficacyand safety profile of this drug during long-term oral administra-tion, Dr. Jacob hopes one day to transition it into human clinicaltrials for VS.

As part of his grant, Dr. Jacob will be matriculating in the Mastersof Medical Science program at Ohio State, focusing his curricu-lum on molecular biology and translational research. He plans toremain clinically active three days a week, seeing exclusivelyOtology and Neurotology patients. This K08 award is another ex-ample of how The Ohio State University Department of Otolaryn-gology uses cutting-edge, patient-centered translational researchto improve clinical care. His mentors on the KO8 are Long-Sheng Chang, PhD and D. Bradley Welling, MD, PhD.

Welcome

The Ohio State University Medical Center Department of Otolaryngology page 10

Publications for 2008/2009

Amit Agrawal , MDSharma S, Casto BC, Fisher JL, Knobloch TJ, Agrawal A. , Weghorst CM.(2009). Oral cancer in Appalachia. Journal of Health Care for the Poorand Underserved. Journal of Health Care for the Poor and Underserved.

Waltonen J, Schuller DE, Ozer E, Agrawal A. (2009). Tonsillectomy vs.deep tonsil biopsies in detecting occult tonsil tumors. Laryngoscope. Vol. 119,no. 1. (January 1): 102.

Yang L, Lang JC, Balasubraman P, Jatana K, Schuller D, Agarwal A,Zborowski M, Chalmers JJ. (2009). Optimization of an enrichment processfor circulating tumor cells from the blood of head and neck cancer patientsthrough depletion of normal cells. Biotechnology and Bioengineering, 102(2), 521-34.

Agrawal A, Hussein O, Schuller DE. (2008). Esophageal reconstructionwith larynx preservation using forearm free flap. Laryngoscope, 118(10),1750-2.

Agrawal A, Hall NC, Ringel MD, Povoski SP, Martin EW. (2008). Com-bined Use of Perioperative TSH-stimulated 18F-FDG PET/CT imaging andgamma probe radioguided surgery to localize and verify resection of iodinescan-negative recurrent thyroid carcinoma. Laryngoscope dec;118(12):2190-4.

Oplatek A, Liu J, Agrawal A. (2008). Pathology quiz case: Atypical lipoma-tous tumor. Arch Otolaryngol Head Neck Surg, 134(9), 1013, 1014-5.

Ozer E, Agrawal A, Ozer HG, Schuller DE. (2008). The impact of surgery inthe management of the head and neck carcinoma involving the carotid artery.Laryngoscope, (10), 1771-4.

Lauren Bakaletz, PhDBookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G,Bakaletz LO. (2008). A carcinoembryonic antigen-related cell adhesion mol-ecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzaecolonization of the chinchilla nasopharynx via the outer membrane proteinP5-homologous adhesin. Infect Immun, 76(1):48-55.

Novotny LA, Partida-Sanchez S, Munson Jr. RS, Bakaletz LO. (2008). Dif-ferential uptake and processing of an OMP P5-derived immunogen by chin-chilla dendritic cells. Infect Immun, 76(3).

Kamran Barin, PhDZeinali S, Hemami H, Barin K, Parnianpour M, Shirazi-Adl A.(2008).Dynamic stability of spine using stability-based optimization and musclespindle reflex. IEEE Transactions on Neural Systems and RehabilitationEngineering, 16(1), 106-18.

Long-Sheng Chang, PhDChang LS,Welling DB. (2009). Molecular biology of vestibular schwan-nomas.Methods In Molecular Biology (Clifton, N.J.). Vol. 493. (January 1):163.

Dorogova NV, Akhmameteva EM, Kopyl SA, Gubanova NV, Yudina OS,Omelyanchuk LV, and Chang LS. (2008). The role of drosophila merlin inspermatogenesis. BMC Cell Biol. 9, 1-15.

Jacob A, Lee TX, Neff BA, Miller S, Ratner, N, Welling DB, Chang LS.(2008). PI3-kinase/AKT pathway activation in human vestibular schwan-noma. Otol Neurotol, 29, 58-68.

Subinoy Das, MDBecker AM, Das S, et. al, Kountakis SE. (2008). Serum inflammatory pro-tein profiles in patients with chronic rhinosinusitis undergoing sinus surgery: Apreliminary analysis. Am J Rhinol. March, 139-143.

Das S,Maeso PA, et. al., Kountakis SE. (2008). The use of portable intraop-erative computed tomography scanning for real-time image guidance: A pilotcadaver study. Am J Rhinol. March, 166-169.

Charles Elmaraghy, MDJatana K, Elmaraghy CA. (2008). Bilateral vestibular stenosis from NasalCPAP and Cannula. OHNS, 137(2), 261-262.

Russell Faust, MD, PhDFaust RA. (2008). Paradigm shift in pediatric surgery: Invasion of the robots.Clinical Pediatrics, 47(2): 122-127.

L. Arick Forrest, MDHusein OF, Husein TN, Gardner R, Chiang T, Larson DG, Obert K, Thomp-son J, Trudeau MD, Dell DM, Forrest LA. (2008). Formal psychologicaltesting in patients with paradoxical vocal fold dysfunction. Laryngoscope,118(4), 740-747.

Abraham Jacob, MDJacob A, Lee TX, Neff BA, Miller S, Ratner, N, Welling DB, Chang LS.(2008). PI3-kinase/AKT Pathway Activation in Human Vestibular Schwan-noma. Otol Neurotol, 29, 58-68.

Jatana K, Jacob A, Slone HW, Ray-Chaudhury A, Welling DB (2008).Spinal myxopapillary ependymoma metastatic to bilateral internal auditorycanals. Annals of Otology, Rhinology & Laryngology, 117(2), 98-102.

Pawan Kumar, PhDKumar P, Gao Q, Ning Y, Wang Z, Krebsback PH, and Polverini PJ. (2008).Arsenic trioxide enhances the therapeutic efficacy of radiation treatment oforal squamous carcinoma while protecting bone. Molecular Cancer Thera-peutics, 7, 2060-2069.

Kumar P, Ning Y, Polverini PJ. (2008). Endothelial cells expressing Bcl-2promotes tumor metastasis by enhancing tumor angiogenesis, blood vesselleakiness and tumor invasion. Lab Invest, 88, 740-749.

Bomjun Kwon, PhDKwon BJ, van den Honert C. (2009). Spatial and temporal effects ofinterleaved masking in cochlear implants. Journal of the Association forResearch in Otolaryngology, 10, 447-457.

Jas Lang, PhDYang L, Lang JC, Balasubraman P, Jatana K, Schuller D, Agarwal A,Zborowski M, Chalmers JJ. (2009). Optimization of an enrichmentprocess for circulating tumor cells from the blood of head and neckcancer patients through depletion of normal cells. Biotechnology andBioengineering, 102 (2), 521-34.

Colella S, Colella S, Richards KL, Bachinski LL, Baggerly KA, Tsavachidis S,Lang JC, Schuller DE, Krahe R. (2008).Molecular signatures of metastasisin head and neck cancer. Head Neck.(10),1273-83

Susan Nittrouer, PhDNittrouer S. (2009). Early Development of Children with Hearing Loss. PluralPublishing (San Diego).

Publications

Publications for 2008/2009

The Ohio State University Medical Center Department of Otolaryngology page 11

Nittrouer S, Lowenstein JH. (2009). Does harmonicity explain children’s cueweighting of fricative-vowel syllables? J. Acoust. Soc. Am. 125, 1679-1692.

Nittrouer S, Lowenstein JH, Packer R. (2009). Children discover the spectralskeletons in their native language before the amplitude envelopes. J. Exp.Psych.: Human Percep. and Perf., 35, August.

Nittrouer S, Lowenstein JH. (2008). Spectral structure across the syllablespecifies final-stop voicing for adults and children alike. J. Acoust. Soc. Am.123, 377-385.

McGowan R S, Nittrouer S, Chenausky K. (2008). Speech production oftwelve-month-old children with and without hearing loss. J. Speech Lang.Hear. Res, 51, 879-888.

Lowenstein JH, and Nittrouer S. (2008). Patterns of acquisition of nativevoice onset time in English-learning children. J. Acoust. Soc. Am. 124,1180-1191.

Enver Ozer, MDWaltonen J, Schuller DE, Ozer E, Agrawal A. (2009). Tonsillectomy vs. deeptonsil biopsies in detecting occult tonsil tumors. Laryngoscope. Vol. 119, no. 1.(January 1): 102.

Ozer E, Agrawal A, Ozer HG, Schuller DE. (2008). The Impact of Surgeryin the Management of the Head and Neck Carcinoma Involving the CarotidArtery. Laryngoscope, (10), 1771-4.

Ozer E,Waltonen J. (2008). Transoral Robotic Nasopharyngectomy: A NovelApproach for Nasopharyngeal Lesions. Laryngoscope, 118(9), 1613-6.

Quintan Pan, PhDMitra RS, Goto M, Lee JS, Maldonado D, Taylor JMG, Pan Q, Carey TE,Bradford CR, Prince ME, Cordell KG, Kirkwood KL, and DiSilva NJ (2008)Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secre-tion, which is associated with poor survival in low N-stage squamous cell carci-noma. Cancer Res. 68:3959-3969.

David Schuller, MDKlopfenstein KJ, Scott S, Schuller DE, Ruymann F. (2008). ProlongedSurvival with Continuous Infusion Topotecan: A Report of 2 Cases. Journal ofPediatric Hematology Oncology, 30(6), 468-470.

Samlowski WE, Moon J, Kuebler JP, Nicols CR, Gandara DR, Ozer H,Williamson SK, Atkins JN, Schuller DE, Ensley JF. (2008). Evaluation of thecombination of docetaxel/carboplatin in patients with metastatic or recurrentsquamous cell carcinoma of the head and neck (SCCHN): a Southwest Oncol-ogy Group Phase II study. Cancer Invest 25(3), 182-188.

Agrawal A, Hussein O, Schuller DE. (2008). Esophageal Reconstructionwith Larynx Preservation using Forearm Free Flap. Laryngoscope, 118(10),1750-2.

Ozer E, Agrawal A, Ozer HG, Schuller DE. (2008). The Impact of Surgeryin the Management of the Head and Neck Carcinoma Involving the CarotidArtery. Laryngoscope, (10), 1771-4.

Yang L, Lang JC, Balasubraman P, Jatana K, Schuller D, Agarwal A,Zborowski M, Chalmers JJ. (2009). Optimization of an enrichment processfor circulating tumor cells from the blood of head and neck cancer patientsthrough depletion of normal cells. Biotechnology and Bioengineering, 102(2), 521-34

Colella S, Colella S, Richards KL, Bachinski LL, Baggerly KA, Tsavachidis S,Lang JC, Schuller DE, Krahe R. (2008).Molecular signatures of metastasis inhead and neck cancer. Head Neck. (10),1273-83

Stephen Smith, MDSmith Jr. SP, Buckingham ED, Williams III EF. (2008).Management ofcutaneous juvenile hemangiomas. Facial Plast Surg 24, 050-064.

Janatan K, Smith SP,Williams III EF. (2008). The scientific basis for lipo-transfer; Is fat the ideal filler? Facial Plastic Clinics of Norht America, 16(4),443-8.

Theodoros Teknos, MDWorden FP, Kumar B, Lee JS, Wolf GT, Cordell KG, Taylor JMG, Urba SG,Eisbruch A, Teknos TN, Chepeha DB, Prince ME, Tsien CI, DiSilva NJ,Miller TH, Wallace NE, Bauer JA, Bradford CR, Carey TE. (2008). Chemos-election as a strategy for organ preservation in advanced oropharynx cancer:Response and survival positively associated with HPV16 copy number. JCO Jul1, 3128-3137

Worden FP, Kumar B, Lee JS, Wolf GT, Cordell KG, Taylor JMG, Urba SG,Eisbruch A, Teknos TN, Chepeha DB, Prince ME, Tsien CI, DiSilva NJ,Miller TH, Wallace NE, Bauer JA, Bradford CR, Carey TE. (2008). EGFR,p16, HPV Titer, BclXL and p53, gender and smoking as indicators of responseto therapy and survival in oropharyngeal cancer. JCO Jul 1, 3138 – 3146.

D. BradleyWelling, MD, PhDChang LS,Welling DB. (2009).Molecular biology of vestibular schwannomas.Methods In Molecular Biology (Clifton, N.J.). Vol. 493. (January 1): 163.

Ealy M, ChenW, Ryu GY, Yoon JG,Welling DB, Hansen M, Madan A,Smith RJ. (2008). Gene expression analysis of human otoscleroticstapedial footplates. Hear Res, 240, 80-86.

Jacob A, Lee TX, Neff BA, Miller S, Ratner, N,Welling DB, Chang LS.(2008). PI3-kinase/AKT pathway activation in human vestibular schwan-noma. Otol Neurotol, 29, 58-68.

Jatana K, Jacob A, Slone HW, Ray-Chaudhury A,Welling DB (2008).Spinal myxopapillary ependymoma metastatic to bilateral internal auditorycanals. Annals of Otology, Rhinology, & Laryngology, 117(2), 98-102.

Fernandez SA, Wiet GJ, Butler NN,Welling DB, Jarjoura D. (2008).Reliability of surgical skills scores in Otolaryngology residents: Analysis usinggeneralizability theory. Eval Health Prof, 4:419-436.

GregoryWiet, MDFernandez SA,Wiet GJ, Butler NN, Welling DB, Jarjoura D. Reliability ofSurigical Skills Scores in Otolaryngology Residents: Analysis using generaliz-ability theory. Eval. Health Prof. 2008 Dec; (4): 419-36. Epub 2008 Oct 7.

Publications

The Ohio State UniversityDepartment of Otolaryngology -Head and Neck Surgery

Eye and Ear Institute

915 Olentangy River Rd., 4th Floor

Columbus, Ohio 43212

614-293-8150

ent.osu.edu

Non-Profit Org.U.S. Postage

PA I DColumbus, OhioPermit No.711

In his introduction of the competition, Academic Bowl coordinator J.David Osguthorpe, MD, predicted that the winning medical schoolresidency team would answer 85 percent of Bowl questions correctly.When the dust settled at the conclusion, two of the teams did consid-erably better than that, "proving that these are the top residencyprograms in the country," Dr. Osguthorpe said.

Competing against one another in the AAO-HNS/F Annual MeetingAcademic Bowl were teams of residents from the University of Medi-cine and Dentistry of New Jersey, the University of North CarolinaMedical School, Wake Forest University Medical School, and The OhioState University Medical Center.

Correctly answering 95 percent of presented questions, the teams fromOhio State (Drs. Cherie Ryoo, Ryan Hendricker & David Melon) and theUniversity of North Carolina tied for first place and will share a prizethat includes travel grants to attend the Annual Meeting, as well assubscriptions to the Home Study Course for the residency program.

Presented with 34 clinical questions covering broad areas of otolaryn-gology as well as general medicine, each team was given 10 to 30 sec-onds to agree on an answer. At the same time, answers from theaudience were recorded on individual keypads and compared withresidency team responses.

The AAO-HNSF Education SteeringCommittee organizes the AcademicBowl using questions created byAcademy educational faculty, orselected from educational materialssuch as the Home Study Course,Patient of the Month, SIPacs, andthe Slide Lecture Series.

To learn more about the academicbowl and the American Academy ofOtolaryngology please visit theAcademy's webpage athttp://www.entnet.org/

Academic Bowl Championship