Science Online 2010 Open Notebook Science Session
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Transcript of Science Online 2010 Open Notebook Science Session
Open Notebook Science
Jean-Claude Bradley
January 17, 2010
Science Online 2010
Associate Professor of ChemistryDrexel University
The NaH oxidation controversy
Information spreads quickly through the blogosphere
15% NMR yield
Khalid Mirza and Marshall Moritz
Top results on a Google search
Motivation: Faster Science, Better Science
Open Notebook Science Logos (Andy Lang, Shirley Wu)
Sharing: how much and when
There are NO FACTS, only measurements embedded
within assumptions
Open Notebook Science maintains the integrity of data
provenance by making assumptions explicit
TRUST
PROOF
The Log makes Assumptions Explicit
The Rationale of Findings Explicit
Raw Data Made Public
Splatter?
Some liquid
YouTube for demonstrating experimental YouTube for demonstrating experimental set-upset-up
Calculations Made Public on Google Spreadsheets
Revision History on Google Spreadsheets
Wiki Page History
Comparing Wiki Page Versions
Proof of Purity with interactive NMR spectrum using JSpecView and
JCAMP-DX
Linking to Molecules in Chemistry Databases
(Andy Lang, Tony Williams)
Open Data JCAMP spectra for education
(Andy Lang, Tony Williams, Robert Lancashire)
Link Spectral Game to Open Educational Content
The Ugi reaction: can we predict precipitation?
Can we predict solubility in organic solvents?
Crowdsourcing Solubility Data
ONS Submeta Award Winners
ONS Challenge Judges
Solubilities collected in a Google Spreadsheet
Rajarshi Guha’s Live Web Query using Google Viz API
Data provenance: From Wikipedia to…
…the lab notebook and raw data
Students and Judges co-Authors on ONS Solubility Book
•Concentration (0.4, 0.2, 0.07 M)•Solvent (methanol, ethanol, acetonitrile, THF)•Excess of some reagents (1.2 eq.)
How does Open Notebook Science fit with traditional publication?
Paper written on Wiki
References to papers, blog posts, lab notebook pages, raw
data
Paper on Journal of Visualized Experiments (JoVE)
Pre-print on Nature Precedings
ChemSpider Automated Mark-up of Chemical Names
How bad is it? Try to find the solubility EGCG?
=2.3 g/L
WTF?!
The End of the Chain of Provenance
The Scandal of Bell’s Lab Notebook