Open Notebook Science

Jean-Claude Bradley

May 24, 2010

IGERT NSF meeting

Associate Professor of ChemistryDrexel University

What is a Scientific Precedent?

What is a Scientific Publication?

What is Peer Review?

What is Scholarship?

How bad is our current system? Try to find the solubility EGCG?

=2.3 g/L

WTF?!

The NaH oxidation controversy

15% NMR yield

Khalid Mirza and Marshall Moritz

Top results on a Google search

To Cite or Not to Cite?

“I would never consider a claim made in a patent as blocking an author's claim of novelty.” Langmuir Editor

What is a Scientific Precedent in Academia?

What is a Scientific Precedent in Patent Law?

What is Scholarship?

What is Peer Review?

The Scandal of Bell’s Lab Notebook

Motivation: Faster Science, Better Science

TRUST

PROOF

Crowdsourcing Solubility Data

ONS Challenge Judges

ONS Submeta Award Winners

Data provenance: From Wikipedia to…

…the lab notebook and raw data

•Concentration (0.4, 0.2, 0.07 M)•Solvent (methanol, ethanol, acetonitrile, THF)•Excess of some reagents (1.2 eq.)

How does Open Notebook Science fit with traditional publication?

Paper written on Wiki

References to papers, blog posts, lab notebook pages, raw

data

Paper on Journal of Visualized Experiments (JoVE)

Pre-print on Nature Precedings

BUT…

Open Access: the Choice that Keeps Giving.. and Giving…

Beware of your addiction to metrics: redundancy will reduce

them

ONSArchive: Semi-Automated Snapshot of the Entire Scientific Record

Lulu.com Data Disks

Solubility Prediction (Andy Lang uses Abraham Model)

Reaction Attempts Book

Reaction Attempts Book: Reactants listed Alphabetically

For all Formats of ONS Projects

Conclusions

•The vehicles available to communicate science will continue to evolve.

•As long as proof is valued over trust there is no limit to what useful forms will emerge.