EPA + DHAEssential Fatty Acids 1000mg

Why use Mi-Vitamin™ Omega-3?Mi-VitaminTM Omega-3 contains MEG-3TM fish oil.

• MEG-3TM is the most trusted source of EPA/DHA omega-3 from fish oil – without the fishy taste or smell • MEG-3TM is purified for safety, concentrated for potency and sustainably sourced from clean, omega-3 rich ocean fish

PURITY LEVELS OUTPERFORM AGGRESSIVE INDUSTRY LIMITS

GOED: Global Organization for EPA and DHA EC: European Commission

• MEG-3TM fish oils meet the most stringent purity requirements for fish oils established by global organizations

FRESHNESS LEVELS OUTPERFORM AGGRESSIVE INDUSTRY LIMITS

• Fresh fish oil is characterized by minimal levels of oxidation The key parameters that measure the oxidation level of fish oil are Peroxide Value (PV) and p-Anisidine Value (p-AV)

MEG-3TM – Sustainable Source

• MEG-3TM is sourced from wild-caught, sustainable fisheries that adhere to the strict regulations of government agencies in the Peruvian upwelling region, where the cold Antarctic waters meet the steep continental shelf off the west coast of South America. This area is one of the richest and most bio-diverse marine environments in the world resulting in an environmentally responsible and entirely sustainable fishery

∙ Contributes to the normal function of the heart

∙ DHA contributes to maintenance of normal brain function

www.atlife.co.za

Marketed by At Life Products (Pty) Ltd, South AfricaTel: 0800 434 444E-mail: info@atlife.co.zawww.atlife.co.za

Mi-Vitamin™ is an At Life registered trademarkMEG-3™ is a trademark of DSM

Omega-3TM

References:1. Birch, E, et al. A randomised controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000 Mar; 42(3): 174-81.2. Willatt, P, et al. Influence of long-chain polyunsaturated fatty acids on infant cognitive function. Lipids. 1998 Oct; 33(10): 973-80.3. Helland, I, et al. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age. Pediatrics. 2003 Jan; 111(1): e39-44.4. Nurk E, Drevon CA, Refsum H, Solvoll K, Vollset SE, Nygàrd O, Nygaard HA, Engedal K, Tell GS, Smith AD. Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study. Am J Clin Nutr. 2007 Nov; 86(5): 1470-8.5. Dullemeijer C, Durga J, Brouwer IA, van de Rest O, Kok FJ, Brummer RJ, van Boxtel MP, Verhoef P. n-3 fatty acid proportions in plasma and cognitive performance in older adults. Am J Clin Nutr. 2007 Nov; 86(5): 1479-85.6. Arch Neurol. 2003 Jul; 60(7): 940-6. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, Aggarwal N, Schneider J. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush Alzheimer’s Disease Centre, Rush-Presbyterian-St Luke’s Medical Centre, Chicago, IL 60612, USA.7. Song C, Zhao S. Omega-3 fatty acid eicosapentaenoic acid. A new treatment for psychiatric and neurodegenerative diseases: a review of clinical investigations. Expert Opin Investig Drugs. 2007 Oct; 16(10): 1627-38. Review.8. Stevens, L, et al. EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids. 2003 Oct; 38(10): 1007-21.9. Innis, SM. Dietary (n-3) fatty acids and brain development. J Nutr. 2007; 137: 855-59.10. Lauritzen, L, et al. The essentiality of long-chain n-3 fatty acids in relation to development and function of the brain and retina. Progress in Lipid Research. 2001; 40(1-2): 1-94.11. Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F. “Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults”. Int J Obes Relat Metab Disord. 1997 Aug; 21(8): 637-43.12. Logan AC. “Omega-3 fatty acids and acne”. Arch Dermatol. 2003 Jul; 139(7): 941-2; author reply 942-3.13. Bittiner, SB, et al. A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis. The Lancet, Feb 20, 1988, 378-80.14. Balk, E, Chung, M, Lichtenstein, A, et al. Effects of Omega-3 Fatty Acids on Cardiovascular Risk Factors and Intermediate Markers of Cardiovascular Disease. Evident Report / Technology Assessment, Number 93. Agency for Health Research and Quality (AHRQ). March 2004.15. Libby, P, et al. Inflammation and atherosclerosis. Circulation. 2002; 105: 1135-43.16. Chamorro, A. Role of Inflammation in Stroke and Atherothrombosis. Cerebrovasc Dis. 2004;17(supl 3): 1-5.17. Mozaffarian, D, et al. Effect of fish oil on heart rate in humans. A meta-analysis of randomized controlled trials. Circulation. 2005; 112:1945-52.18. Leaf, A, et al. Clinical prevention of Sudden Cardiac Death by n-3 Poly-unsaturated Fatty Acids and Mechanism of Prevention of Arrhythmias by n-3 Fish Oils. Circulation. 2003; 107: 2646-52.19. Nakamura Y, Ueno Y, Tamaki S, Kadowaki T, Okamura T, Kita Y, Miyamatsu N, Sekikawa A, Takamiya T, El-Saed A, Sutton-Tyrrell K, Ueshima H. Fish consumption and early atherosclerosis in middle-aged men. Metabolism. 2007 Aug; 56(8): 1060-4.20. Joint WHO/FAO Expert Consultation on Diet, Nutrition and the Prevention of Chronic Diseases. 2002. Geneva, Switzerland.

Arsenic (ppm)0.1

<0.1

n/s

GOED EC MEG-3TM

Cadmium (ppm)0.1

0.01n/s

GOED EC MEG-3TM

Mercury (ppm)0.1

0.005n/s

GOED EC MEG-3TM

Lead (ppm)0.1

0.05

0.1

GOED EC MEG-3TM

Peroxide Value (PV)

52

GOED EP MEG-3TM

BP

10 10

p-Anisidine Value (p-AV)30

1520

30

GOED EP BP MEG-3TM

Low

er is

bett

er

EP: European Pharmacopoeia

BP: British Pharmacopoeia

Mi-Vitamin @MiVitamin atlife_mivitamin

DD-7883 - At Life - Mi Vitamin Omega 3 - A4 Brochure 10-2018.indd 1 10/22/2018 12:08:46 PM

Diagram 2: Benefits of Omega-3 fatty acids (DHA/EPA) for the Heart

1. May lower LDL cholesterol

2. Shift in LDL cholesterol particle size and

buoyancy to be cardio protective

3. May raise HDL cholesterol

4. Better LDL / HDL Ratio

5. TG and VLDL production in liver (14)

1. Acts as an anti-inflammatory -

↓ Chronic inflammation in the heart

and blood vessels (15, 16)

2. Better heart rate (17)

3. Arrhythmia (18)

4. Risk of angina, heart attack and

stroke (15, 16)

1. Help prevent build-up of plaque on

artery walls (19)

2. Better blood flow

3. Vasodilation (↓ Blood pressure)

Mi-Vitamin™ Omega-3Omega-3 fatty acids are essential nutrients found in fish and certain plant oils. They include ALA (alpha-linolenic acid), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Of the three, EPA and DHA help support heart health as well as normal growth and development.

Why is consuming EPA and DHA important?

Diagram 1: Understanding the Omega-3 Poly-unsaturated fatty acid family

Each of these Omega-3 fatty acids is considered essential, meaning that they cannot be synthesized by the human body. Humans do have limited ability to convert dietary ALA to EPA and crucial DHA, however the efficiency of the conversion is very low (< 5%), and dietary intake of EPA and especially DHA is necessary to maintain sufficient amounts in the body.

What are the health benefits of EPA/DHA?

More than 20 000 scientific publications support the numerous health benefits of EPA/DHA omega-3 fish oil. These studies suggest that the combination of EPA and DHA found in fish works synergistically to provide benefits in the following areas:

• Normal Brain function - Cognitive and learning development in infants (1,2,3) - Cognitive function in all life stages (4,5) - Reducing the risk of Alzheimer’s (6) - Depression (7) - Attention Deficit Hyperactivity Disorder (ADHD) (8)• Normal development of the brain, eyes and nervous system (9,10)• Effective for obesity and weight loss (11)• Healthy skin and hair (12,13)• Healthy heart and cardiovascular system

How does EPA/DHA omega-3 fish oil support heart health?

While the research is still emerging in some areas, the research supporting the benefits of EPA/DHA omega-3 for heart health is strong.

• Numerous clinical studies show that EPA/DHA dose-dependently lower plasma triglyceride levels • These fatty acids are thought to work by dampening production of triglycerides and VLDL in the liver • They can also increase HDL-cholesterol concentrations and improve the LDL/HDL ratio • EPA/DHA provide a desirable shift in the LDL particle size and buoyancy, changing from a small dense particle to a bigger more buoyant particle, a shift that is believed to be cardio-protective

Who should use Mi-Vitamin™ Omega-3?

Experts agree that people are not consuming enough EPA/DHA in their daily diets. In fact most people consume less than 100 mg of EPA/DHA per day.

• One way to close this nutritional gap is to consume fortified foods or dietary supplements containing these health-giving natural compounds• Globally, recommended intakes for individual long-chain omega-3 have been developed and consistently indicate that 250 to 500 mg/day of EPA and DHA should be consumed for general health and cardiovascular disease risk reduction

How should Mi-Vitamin™ Omega-3 be used?Required and Recommended EPA & DHA intake: (Adapted from GOED at http://www.goedomega3.com/index.php/files/download/304)

www.atlife.co.za www.atlife.co.za

The problem: Consumers worldwide are not consuming enough LC Omega-3s!Estimated average daily intakes of EPA and DHA (mg/day)

750

500

250

Bul

garia

Chin

a

Rom

ania

Hun

gary

Colo

mbi

a

Bra

zil

Arg

entina

Pola

nd

Sout

h Afric

a

Czec

h Re

publ

ic

Aust

ria

Ger

man

y

Irela

nd

Net

herlan

ds

Italy

Switze

rlan

d

UK

USA

Gre

ece

Aust

ralia

Isra

el

Russ

ia

Fran

ce

Den

mar

k

Swed

en

Chile

UAE

Cana

da

New

Zea

land

Jam

aica

Spai

n

Portug

al

Kore

a

Finl

and

Nor

way

Mal

aysi

a

Japa

n

Icel

and

Zone of consensus for nutritional intake recommendations

Adap

ted

from

GOED

Om

ega

at

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Organisation Target population Recommendation General adult population 250 mg–2* g/day EPA + DHA 300 mg/day EPA + DHA of which at least 200 mg/day is DHAFAO/WHO20 Adequate Intake(AI) levels of: EPA + DHA 100 – 150 mg for 2-4 years 2 - 18 years EPA + DHA 150 – 200 mg for 4-6 years EPA + DHA 200 – 300 mg for 6-10 years to the adult value assigned at age 10 yearsInternational Society General adult population for for the Study of Fats cardiovascular healthand Lipids(ISSFAL) Pregnant/lactating women DHA: 200 mg/dayWorld Association of Perinatal Medicine World Gastroenterology Organization

* For secondary prevention of CHD (Coronary Heart Disease)

What does Mi-Vitamin™ Omega-3 contain?

Nutritional Information:Each softgel capsule contains:Fish oil 1000 mg EPA (Eicosapentaenoic acid) 180 mg DHA (Docosahexaenoic acid) 120 mgNatural Vit E added as antioxidant 0.47 IU

Inactive ingredients: Gelatin, glycerine, mixed natural tocopherols, sunflower oil

Dosage and Directions: Adults and children over 6 years: Take 1 to 3 capsules per day with meals or as directed by your healthcare professional.Pack Size: 90 softgel capsulesDietary supplements should be taken as part of a healthy, balanced diet.

Pregnant/lactating women 200 mg DHA/day

General adult population 3 – 5 servings/wk of fish

At least 500 mg/day of EPA + DHA

Sources Found in: Canola oil Flax & flaxseed oil Linseed oil Walnuts & Brazil nuts

Found in: Fatty fish like salmon, mackerel, anchovies & sardines

Fish oil

Found in: Fatty fish like salmon, mackerel, anchovies & sardines

Fish oil

Alpha-Linolenic Acid (ALA)

Body efficiency <5% to convert

ALA to DHA

DHA

Normal function of the heart

Maintenance of normal brain function

Contributes to normal brain development

Maintenance of normal vision

EPA

Normal function of the heart

ALA

Source of Energy

At a Daily intake of 250 – 500mg DHA & EPADietary intake of

EPA & especially DHA essential

Eicosapentaenoic Acid (EPA)

Docosahexaenoic Acid (DHA)

Functions

Pregnant/lactating women

LIVER

PLAQUE

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