Post on 26-May-2015
MEDICAL ENGLISH TEAM N° 02
LATEST RESEARCHES ON PSIQUIATRY
INTEGRANTS : CARRIÓN ARCELA FIORELLA
CHIQUINTA SALINAS CRISTIAN
CUSTODIO BALLENA SPENCER
FERNANDEZ MEZA MERCY
FERNANDEZ PEÑA DAYTON
REYES CARRASCO WILLIAM
NEW MELATONIN-BASED THERAPIES
potential advances in the treatment
of
MAJOR DEPRESSION
is one of the leading causes
premature death
disability
AVAILABLE DRUGS
Effective ----- have
substantial limitations
Recent advances
new antidepressant
treatment strategies
AGOMELATINE melatonin-receptor
agonist
EFFECTSChronobiotic, antidepressant, and
anxiolytic
Patients with depression
treated with
AGOMELATINE
not side effects sexu
al
gastrointestinal
metabolic
improves the quality of sleep
reduced waking after sleep on set
Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation
Chromatin modifications
Increased histone-tail acetylation
inhibitors of histone deacetylases (HDACis)
induced
facilitates learning and memory
for harnessing the therapeutic potential of HDACis
requires knowledge of the specific HDAC family member(s)
linked to cognitive
enhancement
the Hdac2 deficiency
in increased synapse number
memory facilitation
Reduced
synapse number
learning impairment of HDAC2-overexpressing mice
were ameliorated by chronic treatment with HDACis
NEUROIMAGING AND
NEUROPSYCHOLOGY OF OBSESSIVE-COMPULSIVE
DISORDER: RECENT ADVANCES
Neuroimaging and Neuropsychology of obsessive-compulsive disorder: RECENT
ADVANCES
This has contributed significantly to our understanding of the neural
basis of this disorder
RESULTS
Structural imaging studies
Volumetric abnormalities in the striatum nucleus and
other structures
Functional Imaging studies
hyperactivity of cortico-striatal circuit-thalamic
orbitofrontal cortex and caudate nucleus
specific
METABOLIC ABNORMALITIES IN
OCD
originDysfunctional
striate nucleus
that "forcing"
to other cortical regions to "take his
place"
New paradigms of neuroactivation
The most recent neuropsychological studies
provided new dates can integrate
the above results
Cognitive deficits in OCD are secondary to system
malfunctions EXECUTIVE
therefore
using more refined designs
Disorder by attention deficit and hyperactivity
The lack of treatment
problems of school performance reduced quality of life in the short, medium and long term increases
the possibility of using drugs having a personality disorder
Disorder by attention deficit and hyperactivity
neurodevelopmental disorder
brain maturationCAUSED BY
alteration in the neurotransmission
dopaminergic and noradrenergic system
causality genetic
psychopathological expression
not dependent on the environment,
The hyperactive need to move more
maintain the required level of alertness while
performing tasks that challenge their working memory
Children who suffer from DADH
more likely than other children to commit crimes when they grow up.
Disorder by attention deficit and hyperactivity
DADH share genetic risk with cigarette smoking
DADH share genetic risk with asma
Early DADH treatment can prevent consume of drug
that SSRIs are no more effective in the treatment of depression than other kinds
of older drugs, such as tricyclic antidepressants
initial treatment
patients with mild or moderate depression
PLACEBO
OTHERS
The cutaneous pathology may mask a psychiatric disorder
diagnosis of autism using tomography
THANKS