MEDICAL ENGLISH TEAM N° 02

LATEST RESEARCHES ON PSIQUIATRY

INTEGRANTS : CARRIÓN ARCELA FIORELLA

CHIQUINTA SALINAS CRISTIAN

CUSTODIO BALLENA SPENCER

FERNANDEZ MEZA MERCY

FERNANDEZ PEÑA DAYTON

REYES CARRASCO WILLIAM

NEW MELATONIN-BASED THERAPIES

potential advances in the treatment

of

MAJOR DEPRESSION

is one of the leading causes

premature death

disability

AVAILABLE DRUGS 

Effective ----- have

substantial limitations

 Recent advances

new antidepressant

treatment strategies 

AGOMELATINE melatonin-receptor

agonist

EFFECTSChronobiotic, antidepressant, and

anxiolytic

Patients with depression 

treated with 

AGOMELATINE

not side effects sexu

al

gastrointestinal

metabolic

improves the quality of sleep

reduced waking after sleep on set

Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation

Chromatin modifications

Increased histone-tail acetylation

inhibitors of histone deacetylases (HDACis)

induced

facilitates learning and memory 

for harnessing the therapeutic potential of HDACis

requires knowledge of the specific HDAC family member(s)

linked to cognitive

enhancement

the Hdac2 deficiency

in increased synapse number

memory facilitation

Reduced

synapse number

learning impairment of HDAC2-overexpressing mice

were ameliorated by chronic treatment with HDACis

NEUROIMAGING AND

NEUROPSYCHOLOGY OF OBSESSIVE-COMPULSIVE

DISORDER: RECENT ADVANCES

Neuroimaging and Neuropsychology of obsessive-compulsive disorder: RECENT

ADVANCES

This has contributed significantly to our understanding of the neural

basis of this disorder

RESULTS

Structural imaging studies

Volumetric abnormalities in the striatum nucleus and

other structures

Functional Imaging studies

hyperactivity of cortico-striatal circuit-thalamic

orbitofrontal cortex and caudate nucleus

specific

METABOLIC ABNORMALITIES IN

OCD

originDysfunctional

striate nucleus

that "forcing"

to other cortical regions to "take his

place"

New paradigms of neuroactivation

The most recent neuropsychological studies

provided new dates can integrate

the above results

Cognitive deficits in OCD are secondary to system

malfunctions EXECUTIVE

therefore

using more refined designs

Disorder by attention deficit and hyperactivity

The lack of treatment

problems of school performance reduced quality of life in the short, medium and long term increases

the possibility of using drugs having a personality disorder

Disorder by attention deficit and hyperactivity

neurodevelopmental disorder

brain maturationCAUSED BY

alteration in the neurotransmission

dopaminergic and noradrenergic system

causality genetic

psychopathological expression

not dependent on the environment,

The hyperactive need to move more

maintain the required level of alertness while

performing tasks that challenge their working memory

Children who suffer from DADH

more likely than other children to commit crimes when they grow up.

Disorder by attention deficit and hyperactivity

DADH share genetic risk with cigarette smoking

DADH share genetic risk with asma

Early DADH treatment can prevent consume of drug

that SSRIs are no more effective in the treatment of depression than other kinds

of older drugs, such as tricyclic antidepressants

initial treatment

patients with mild or moderate depression

PLACEBO

OTHERS

The cutaneous pathology may mask a psychiatric disorder

diagnosis of autism using tomography

THANKS