Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard...
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![Page 1: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/1.jpg)
www.global-campaign.orgwww.nhv-mag.org
Prevention trials pipeline
2006 2008 2009 20102007 2012
MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s View
Female Barrier- Diaphragm
Male Circumcision - Susceptibility
Microbicides – CS-1CS-2
Carraguard
Male Circumcision - Infectiousness
Microbicides• BG/Pro2000•Pro2000• TDF
Oral PrEP - IDU
HSV-2 Treatment -
Infectiousness
HSV-2 Treatment –
Susceptibility
Oral PrEP• MSM
• Heterosexual
IndexPartner
Treatment
Vaccines -Adenovirus-1Adenovirus-2
Vaccines -Prime/Boost
Community VCT and HIV
Support
Oral PrEP -West Africa
![Page 2: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/2.jpg)
www.global-campaign.orgwww.nhv-mag.org
Research Principles
• Research must have a potential benefit.
• Research examines a question to which the answer is unknown.
• Research must be able to answer the question or contribute meaningful information.
• Good research must be unbiased.
• Research is not the same as health care
![Page 3: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/3.jpg)
www.global-campaign.orgwww.nhv-mag.org
Decision-making about research
Community and Civil Society advocates
Ethics Review BodiesResearchers and Sponsors
Data Monitors
![Page 4: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/4.jpg)
www.global-campaign.orgwww.nhv-mag.org
Data Monitors can stop trial if evidence that
test product is definitely effective;
![Page 5: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/5.jpg)
www.global-campaign.orgwww.nhv-mag.org
Data Monitors can stop trial if evidence that
test product may be causing harm
![Page 6: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/6.jpg)
www.global-campaign.orgwww.nhv-mag.org
Data Monitors can stop trial if evidence
that it is futile -- trial can no longer answer the assigned question
![Page 7: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/7.jpg)
www.global-campaign.orgwww.nhv-mag.org
r
PrEP 2004PrEP 2004 --Political --Political controversy can controversy can stopstop trials trials
![Page 8: Www.global-campaign.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s.](https://reader036.fdocuments.us/reader036/viewer/2022070413/5697bfaf1a28abf838c9cda1/html5/thumbnails/8.jpg)
www.global-campaign.orgwww.nhv-mag.org
Managing fall out of CS results
Negative press erupts in South Africa