THE MINISTRY OF HEALTH OF UKRAINENATIONAL UNIVERSITY OF PHARMACY

THE DEPARTMENT OF PHARMACOLOGY

Shtrygol’ S.Yu., Vereitinova V.P., Zaychenko A.V., Pozdniakova A.Yu.

KROK WITHOUT PROBLEMS

Study guide for license test preparing«Krok-1 Pharmacy»

Kharkov-2014

List of medicines that are in tests «KROK-1»Medicines affecting afferent innervations:Local anesthetics1. Lidocain2. NovocaineMedicines affecting efferentinnervations:Cholinergic medicines3. Atropine sulphate4. Pilocarpine5. Proserin (Neostigmine methylsulphate)6. Dithylinum7. BenzohexoniumAdrenergic medicines8. Adrenaline hydrochloride (Epinephrine)9. Ephedrine hydrochloride10. Salbutamol11. Propranolol (Anaprilin) 12. MetoprololHypnotic medicines, Anticonvulsants13. Sodium valproate14. Nitrazepam15. Phenazepam16. Phenobarbital17. LevodopaNarcotic and Non-narcoticAnalgesics, Non-steroidalanti-inflammatory drugs18. Morphine19. Promedol (Trimeperidine)20. Naloxone21. Paracetamol22. Diclofenac sodium23. Acetylsalicylic acid24. Celecoxib25. Meloxycam26. Piroxicam27. Indomethacin28. NimesulideMedicines suppressing andstimulating the centralnervous system29. Aminazine (Chlorpromazine)30. Diazepam31. Droperidol32. Caffeine sodium benzoate33. Amitriptyline

Medicines affecting therespiratory system34. Acetylcysteine35. Glaucin36. Ambroxol37. Theophelline38. Cromoline sodiumCardiotonic medicines39. Digoxin40. Digitoxine41. Corglycon42. DobutamineAnti-anginal, anti-arithmicmedicines43. Nitroglycerine44. Isosorbide mononitrate45. Amiodaron46. Molsidomine47. Panangin48. VerapamilAntihypertensive, Anti-athero-sclerotic medicines 49. Lisinopril50. Enalapril51. Magnesium sulphate52. Phenofibrate53. DoxazosineMedicines affecting thegastro-intestinal tract54. Famotidin55. Ranitidine56. Omeprasol57. Bismute subcitrate58. Almagel59. Bisacodyl60. Pancreatinum61. Ursodeoxycholic acidMedicines affecting the renalfunction and miometry62. Hydrochlorthiazide63. Furosemide64. Triamteren65. OxytocinMedicines affecting the bloodsystem66. Cyanocobalamine67. Vicasol68. Heparin69. Streptokinasa70. Fibrinogen

Vitamin-containing medicines71. RetinolHormonal medicines72. L-thyroxin73. Prednisolone74. Insulin75. Glibenclamide76. DexametazoneSalts.77. Calcium chlorideAnti-allergic medicines78. Dimedrol79. LoratadineMedicines that used in poisonings. Nitrofurans. Disinfectants80. Kalii permanganas81. Nifuroxazide82. Alcoholic iodine solutionAntibiotics. Sulphonamide medicines83. Benzylpenicillin84. Amoxicillin85. Doxycycline hydrochloride86. Tetracycline87. Cefotaxime88. Ceftriaxon89. Phthalazol90. Co-trimaxozoleAntituberculous medicines91. Isoniazid92. Rifampicine93. Rovamycine94. StreptomycyneAntiviral medicines95. AcyclovirAntihelminthic medicines. Antifungal medicines96. Chingamin97. MetronidazoleNootropic medicines98. PyracetamAntidotes. Iron-contaning drug99. Deferoxamine100. UnitiolumAngiotensin II receptor antagonist101. Losartanα2 adrenomimetics102. Clonidine

2

GENERAL PHARMACOLOGY1. A patient with arterial hypertension was administered a non-prescription drug for symptomatictreatment of rhinitis. What pharmacological form should be recommended the patient in order toreduce as much as possible the likelihood of development of undesirable systemic vasoconstriction?a) Dropsb) Tabletsc) Aerosold) *Ointmente) Gel

2. A 56-year-old patient suffering from essential hypertension was prescribed an inhibitor ofangiotensin converting enzyme (ACE) and a potassium-sparing diuretic. Such combination is:a) Reasonable because it potentiates hypotensive effect of ACE inhibitorb) Unreasonable because it increases risk of orthostatic collapse developmentc) Reasonable because it decreases risk of hyperkaliemia developmentd) Unreasonable because it reduces hypotensive effect of ACE inhibitore) *Unreasonable because it increases risk of hyperkaliemia development

3. Continuous taking of drug results in reduction of its efficiency. This phenomenon called:a)* Habituationb) Cumulationc) Sensibilizationd) Dependencee) Tachyphylaxis

4. One of the major indicator of drug elimination from the human body is:a). Bioavailabilityb). Volume of distributionc). Bioequivalenced). *Effective halfbreake). Highest concentration in blood

5. A 6-year-old child with pneumonia was prescribed an antibiotic. After the treatment the childbecame deaf. Which antibiotic group might cause this complication?a)* Aminoglycosidesb) Cephalosporinsc) Macrolidesd) Natural penicillin e) Semisynthetic penicillin

6. А patient has been taking isosorbide for stenocardia prevention for quite а long time. Now hеnotes а significant decrease in the effect of the drug. What is this рhеnomenon called?А. AllergyВ. Physical dependence С. *ToleranceD. CumulationЕ. Potentiation

7. Drug addicts upon termination of action a drug have heavy psychical, neurological and somaticviolations. What is the name of this symptom complex?A* Abstinente syndromeB Tachyphylaxis

3

C Sensitization D CumulationE Tolerance

8. What does period of semiejection (T1/2) mean? A* Interval of time for which the concentration of preparation in plasma of blood diminishes on50%B Volume of plasma of blood, which rids of preparation for time unit C Time of complete leadingout of preparation is from an organism D Speed of leadingout of preparation is through budsE Betweenness by speed of leadingout of preparation and by his concentration in plasma of blood

9. From annotation on magnesium sulfate you know that this preparation is prescribed as aanticonvulsant drug. What rout of administration of injection should be chosen for getting of thispharmacological effect?A* intramuscular injectionB sublingualC peroralD rectalE inhalation

10. For rapid relief of symptoms of stenocardia a patient takes nitroglycerine in capsules. What isthe most rational rout administration for this preparation?A* SublingualB OralC RectalD InhalationE Hypodermic

11. A doctor prescribed bisacodyl to a patient with a chronic constipation. In 3 weeks of treatment apatient paid a regard to diminishing purgative effect. With what side effect is it related? A* Adaptation (tolerance)B PredilectionC SensitizingD CumulationE Dysbacteriosis

12. At poisoning by phosphoorganic compound an atropine sulfate was used. What phenomenon isunderlaid in antidotal action?A* AntagonismB Synergism C Adaptation D Chemical incompatibilityE Potentiation

13. Answer to the doctor question, what is the name of the phenomenon, when at the prolongedusing of preparation its efficiency goes down?A* Adaptation (tolerance)B AllergyC Cumulation D AddictionE Tachyphylaxis

4

14. Consult a doctor-interner concerning the meaningof term "elimination":A* Biotransformation + exerectionB BiotransformationC ExecrectionD AccumulationE Absorption + distribution

15. Drug addicts after rapid stoppage of drug usage have severe psychical, neurological and somaticdisorders. What is the name of this complex of symptoms?A* AbstinenceB IdiosyncrasyC Sensitizing D CumulationE Tolerance

16. Which properties of drug determine the ability of drug to penetrate through the blood brainbarrier?A* lipids solubilityB water solubilityC strong protein bond D ionization stateE long term of half- rearing

17. Pregnant woman used big doses of retinol during 1st trimester of pregnancy and gothypervitaminosis. This drug may induce abnormalities of fetus. Name this side effect.A* Teratogenic actionB CumulationC DysbacteriosisD AddictionE Cancerogenic action

18. Imagine yourself as a pharmacist in interhospital pharmacy. Try to explain nurse what doestolerance mean? A* Impairment of therapeutic efficacy after repetitive drug administrationB Slowing-down metabolism of medicine in a liver C Increasing of therapeutic efficacy of drugD Slowing down of drug eliminationE High absorption from gastrointestinal tract

19. Give the answer to nurse: what is the effective half-life medicine period?A* It is time when medicine concentration in plasma gets down to 50%B It is time when medicine can reach bloodstreamC It is time when medicine can spread all over organismD It is time when medicine can get maximum concentration in plasmaE It is time when all dose of medicine can eliminated from organism

20. The amount of drug comes to the systemic bloodstream from the site of administration isdetermined as: A* bioavailability B period half- adsorptionC effective half-lifeD volume of distributionE period half - elimination

5

21. A patient with uncommon reaction to a medicine was delivered to an intensive care department.What is the name for sensivity enhancement and distorted reaction to medications caused byhereditary enzyme defects?a)* idiosyncrasyb) drug habituationc) drug dependenced) cumulatione) summation

22. At maternity department a child with rudimentary handy was born. What is the name for actionof drugs which provokes fetus’s birth defects?a)*teratogenicb) allergicc) cancerigenicd) localizee) resorptive

23. To contagion isolation ward a patient who had scarlatina was delivered. The doctor prescribedthe medicine in dose which exceeds a medium therapeutic one in 2-3 times. What is the name forsuch a dose?a)*loading doseb) course dosec) toxic dosed) mortal dose e) once a day dose

24. To narcological department a patient was delivered. His diagnosis was morphine dependence.The doctor noted decreasing of morphine pharmacological activity. What is the name for thephenomenon when the effectiveness of drug reduces after repeated introduction?a) * get used to drug (tolerance)b) material cumulationc) functional cumulationd) antagonisme) summation

25. Technician addressed pharmacist: What pharmacokinetic parameter characterizes the timeneeded for absorption of half injected dose from injected point to general circulanion?a)* half – absorption periodb) half – elimination peroid c) constant associationd) functional cumulatione) half – excretion period

26. To obtain a necessary effect a patient was prescribed paracetamol with dimedrol. What is thename for this drug interaction?a)* potentiationb) summationc) symphysisd) antagonisme) antidote

27. Explain to a patient why old people should take medicine in reduced doses.

6

a)*because of slowing-down of drug metabolismb) because of acceleration of drug metabolismc) because of acceleration of drug eliminationd) because of acceleration of drug distributione) because of acceleration of drug absorption

28. Remind you colleague (pharmacist) what is the name for the phenomenon when one medicinereduces action of another one?a)* antagonismb) drug habituationc) sensitizationd) potentiatione) tachyphylaxis

29. What reasonable rout of administration for sodium caffeine benzoate should one choose to treatmigraine? Select from the listed below.a)* peroralb) intra-arterialc) inhalationd) transdermale) rectal

30. After a long-term intake of isosorbide to prevent anginal attack a patient noticed significantdecrease of its action. What is the name for this phenomenon?a)* toleranceb) cumulationc) physical dependenced) allergye) potentiation

31. When a certain drug reduces the effect of another drug, such phenomenon is called:A. *Antagonism B. HabituationC. PotentiationD. SensobilizationE. Tachyphylaxis

32. The ability of drugs to accumulate in the patient’s body is called:A. *CumulationB. SynergismC. AllergyD. AntagonismE. Habituation

33. A patient with moderately severe pneumonia has been administered ceftriaxone 1 time per day. The drug should be taken once a day due to the following properties:A. *Slow excretionB. Cumulative abilityC. Poor absorption from the injection siteD. Wide range of ac tionE. Presence of bactericidal action

7

MEDICINES

1. LidocainTests

1. As a result of cardiac infarction a patient had ventricle arrhythmia. A cardiac rhythm wasnormalized after injection of antiarrhythmic agent with local anaesthetic activity. What drug wasinjected?A LidocainB NovocaineamidC Verapamilum D PananginumE Propranolol2. Lidocaine was injected to a patient with disorders of cardiac rhythm. What pharmacologicaleffect does this medicine have besides local anaesthetic activity?A AntiarrhythmicB Somnolent C Febrifuge D AntidepressantE Nootropic3. Tell doctor-enterner what drug from local anesthetics has antiarrhythmic actions?A LidocaineB DigoxinC MetoprololD PropranololE Chingamin4. What medicine from local anesthetic group is used when a patient has cardiac rate abnormalities?a) lidocainb) paracetamolc) morphine hydrochlorided) sodium caffeine – benzoatee) nitrazepam5. What local anesthetic is it better to buy in a pharmacy for anaesthesia during extraction of tooth?A LidocaineB DicaineC Anaesthesin D SovkaineE Cocaine 6. A patient with a heart rhythm disorder has been given lidocaine. Apart from the local anesthetic effect, this drug has the following pharmacological effect:A AntiarrhythmicB HypnoticC AntipyreticD AntidepressantE Nootropic

2. NovocaineTests

1. During local anaesthetization novocaine solution is usually compounded with solution ofadrenaline hydrochloride. What is the purpose of this action? a). *Vasoconstrictionb). Vasodilatationc). Decrease in smooth muscle tone

8

d). Algesthesia reductione). Increase in smooth muscle tone2. A patient got an injection of 0.25% novocaine solution for the purpose of anaesthetization.Suddenly the patient has presented with red spots, intense sweating, tachycardia, bronchospasme,edema of nasal mucous membrane. What is the cause of this complication?a)* Immediate allergyb) Abstinence syndromec) Tachyphylaxis d) Delayed allergye) Local irritation

3. Atropine sulphateTests

1. For research of internal bottom it is necessary to extend a pupil. What preparation is used for thispurpose clinically?A Atropine sulfateB Pillokarpine hydrochlorideC PirensepineD ProserinE Anaprilin2. At poisoning by phosphoorganic compound an atropine sulfate was used. What phenomenon isunderlain in antidotal action?A AntagonismB Synergism C Adaptation D Chemical incompatibilityE Potentiation3. A patient who has renal colics was prescribed a spasmolytic from M-cholinergic antagonists.What medicine is it?a) atropineb) proserinc) galanthamined) dithyline) benzogecson4. When copying of instruction to clinic use of atropine sulfate in section «Side effects» studentnoted: tachycardia, increase of blood ocular pressure, temperature rice, reddening. What typical sideeffect was missed?a) dry mouthb) drowsec) nausead) vomiting e) excessive sweat5. Name the most typical symptom of poisoning by atropine:A Dilation of pupils, which are irresponsible on lightB Narrowing of pupils which are irresponsive on lightC Perspiration enhancesD BradycardiaE Decline of ophthalmotonus6. A child has accidentlly drunk a solution that was used by his grandmother for glaucomatreatment. The solution turned out to be pilocarpine hydrochloride. What drug can be used as anantidote?a)* Atropinum

9

b) Carbacholinumc) Pentaminumd) Aceclidinume) Benzohexonium7. A 40-year-old patient suffers from bronchial asthma and cardiac rhythm disturbance in form ofbradyarrhythmia. Drug of which pharmacological group should be administered for bronchospasmsuppression? a). * M-cholinergic antagonists (M-anticholinergics)b). M-cholinomimeticsc). Beta-blockersd).Cholinesterase inhibitorse). Muscle relaxant8. During an operation a dentist needs to reduce salivation in a patient. The dentist has to use a drugof the following pharmacological group:a)* Muscarinic receptors blockers b) Muscarinic cholinomimeticsc) Muscarinic and nicotinic cholinomimeticsd) Adrenoceptor blockere) Adrenomimetics9. .A 40-year-old patient suffers from bronchial asthma and cardiac rhythm disturbance in form ofbradyarrhythmia. Drug of which pharmacological group should be administered for bronchospasmsuppression? a). * Muscarinic receptor blockers (M-cholinergic antagonist)b). Muscarinic cholinomimeticsc). Beta-adrenoceptor blockersd).Anticholinesterase drugse). Muscle relaxants10. А patient has bееn administered a spasmolytic from the group of muscariniс receptorantagonists as а part of complex treatment for renal colics. Specify this drug:А. *АtrоpinеВ. ВеnzohехоniumС. NeostigmineD. GalantamineЕ. Dithylinum11. A 40-year-old patient has a history of bronchial asthma and bradyarrhythmia. In order toeliminate bronchospasm, the drugs of the following pharmacological group should be administered:A *M-anticholinergicsB в-adrenergic blocking agentsC M-cholinergic agentsD Anticholinesterase agentsE Muscle relaxants12. The patient with hepatic colic has been prescribed spasmolytic of muscarinic receptorantagonists group as a part of his complex therapy. What drug is it?A. *AtropineB. ProserinC. GalantamineD. DithylinE. Benzohexonium

4. PilocarpineTests

1. Recommend a patient with glaucoma a preparation from a group of M-cholinomimetics.

10

A Pilocarpine hydrochlorideB Ephedrine hydrochlorideC Sulfacilum Sodium D Atropine sulfate E Levomycetin2. For treatment of glaucoma a doctor decided to prescribe cholinomimetic agent of direct action.What preparation is it?A Pilocarpine hydrochlorideB Zinc sulfateC Sodium sulfacyl D PlatyphyllinE Atropine sulfate3. Patient with glaucoma was prescribed pilocarpine hydrochloride to decrease pressure. Whatpharmacological group does the medicine belong to?A M-cholinomimeticsB Beta-adrenoceptor antagonistsC SympatholyticsD Ganglionic blockersE Alfa- adrenoceptor antagonists4. Pilocarpine was prescribed. What mechanism of action does this medicine have?a) M - cholinergic receptor stimulationb) M - cholinergic receptor blockadec) α - adrenoreceptors stimulationd) β - adrenoreceptors blockadee) H2 - histamine receptor blockade5. What medicine from cholinotropic group is used for glaucoma treatment, because it reducesintraocular pressure?a) pilocarpineb) atropinec) platyphyllind) scopolaminee) methacin6. Name the drug that causes miosis and lowers intraocular pressureA. *Pilocarpine hydrochlorideB. FenofibrateC. NitrazepamD. Atropine sulphateE. Suxamethonium chloride

5. Proserin (Neostigmine methylsulphate)Tests

1. For the patient of 53 years old glaucoma is diagnosed. For treatment a doctor prescribedanticholinesterase medicine as eye drops. Name this drug.A Proserin B Carbacholin C Pilocarpine hydrochlorid D Atropine sulfate E Aceclidin2. A patient who has glaucoma was prescribed proserin as eye drops. To what pharmacologicalgroup does this medicine belong?a) Anticholinesterase reversible acting agentb) M – anticholinergic drug

11

c) N – cholinomimetic d) Adrenergic blockere) Adrenoceptor agonist3. What should one prefer to suppress intestinal atony in a postoperative period?a) proserinb) atropinec) platyphyllind) pireline) methacin4. Old patient had postoperative atony of the intestine. What anticholinesterase medicine should beprescribed? A ProzerinB DithylinumC Pilocarpin hydrochloride D Atropine sulfate E Metoprolol5. A child was hospitalized with the symptoms of poisoning by the alkaloids of belladonna. Whatpreparation should be used as an antidote? A ProzerinB Magnesium sulfateC Caffeine-sodium benzoateD ParacetamolE Sodium volpro6. Find in your pharmacy reversible-acting anticholinesterase drug for treatment of atony ofinfestine.A ProzerinB PhosphacolC BenzohecsoniumD Atropine sulfateE Dithylin7. A hospital admitted a child with signs of poisoning with belladonna alkaloids. What drug shouldbe applied as an antidote?a). * Proserinb). Magnesium sulfatec). Sodium valproated). Sodium caffeine benzoatee). Paracetamol8. During a surgical operation the muscle relaxant tubocurarine chloride was used. What antagonistshould be injected in order to allow the patient to breathe independently?a). *Neostigmine (Proserinum)b). Cytitonumc). Dithylinumd). Aethimizolum e). Benzohexonium9. A patient with dry mouth, photophobia and blurred vision has bееn delivered to the emergencydepartment. Objectively: the skin is hуреrеmiс, dry, mydriatic pupils and tachycardia are present.He has bееn diagnosed with belladonna alkaloids intoxication. Which of the drugs should bе givenas аn antidote?A. NeostigmineВ. PylocarpineС. АrminD. Aceclidine

12

Е. Dipiroxim10. From the pharmaceutical stock select an anticholinesterase drug to be administered to thepatients with atony of the intestine and urinary bladder in the postoperative period:A. DithylinumB. PhosphacolumC. Atropine sulfateD. BenzohexoniumE. Proserin

6. DithylinumTests

1. To the interhospital pharmacy an order from a surgical department on the medicine of theneuromuscular relaxant group with depolarizing type of action for the leadthrough of surgicalinterferences was made. What medicine was ordered?A DithylinB FamotidineC Atropine sulfate D MethacineE Hygronium.2. An interhospital pharmacy got an order from a surgical department for a depolarizing musclerelaxant for surgical interventions. What drug was ordered?a). * Dithylinumb). Hydroniumc). Nicotined).Methacinee). Atropine sulfate

7. BenzohexoniumTests

1. A patient with hypertensive crisis received an injection of ganglionic blocker benzohexonium.What side effect might be expected after the drug injection?a). * Orthostatic hypotensionb). Diarrheac). Central nervous system depression effectd). Withdrawal (abstinence) syndrome). Taste violation

8. Adrenaline hydrochloride (Epinephrine)Tests

1. A patient after bee's stings has angioedema (Quincke's edema). Which drug should beimmediately inject to eliminate this condition?A Epinephrine hydrochlorideB Sodium chloride C Platyphyllin hydrotartrat D Atropine sulfate E Anaprilin2. For an extension and strengthening of local anesthetic activity of lidocaine also for diminishingof bleeding probability during the extraction of a tooth, a dentist used preparation from the group ofadrenergic agonist. Name this preparation. A Adrenaline hydrochlorideB SalbutamolumC Isadrinum

13

D Prozerin E Anaprilin3. A patient has anaphylactic shock developed after a vaccination. Name the preparation of choicein such a case.A Adrenaline hydrochloride B Anaprilin C Naphthizin D Salbutamol E Dithylin4. Help student from medical university to choose adrenergic drug for treatment of anaphylacticshock. A Adrenaline hydrochlorideB ClofelinC GalasolineD FenoterolE Isadrin5. During the reaction of sensibilisation to benzylpenicillin anaphylactic shock appeared. Whatmedicine should be injected in the place of the antibiotic injection?a) *adrenalin hydrochlorideb) norepinephrine hydrotartratec) atropine sulfated) mesatone) cephtriaxon6. During the sensitifity test for benzylpenicillin a patient developed anaphylactic shock. Thefollowing preparation must be injected around the spot of antibiotic injection:a). * Adrenaline hydrochlorideb). Atropine sulfasec). Propranolold). Noradrenaline hydrotartratee). Ceftriaxon7. During local anaesthetization novocaine solution is usually compounded with solution ofadrenaline hydrochloride. What is the purpose of this action? a). * Vasoconstrictionb). Vasodilatationc). Decrease in smooth muscle toned). Algesthesia reductione). Increase in smooth muscle tone8. Epinephrine is used to prolong the effect of novocaine during infiltration anesthesia. Whatepinephrine action is this effect caused by?A. *VasoconstrictionB. Potentiation of novocaine action at CNS levelC. Suppression of nerve endings and conductors functioningD. VasodilatationE. Suppression of tissue esterases

9. Epedrine hydrochlorideTests

1. A patient after bee’s stings has angioedema (Quincke’s edema). Which drug should beimmediately injected to eliminate this condition?a). * Epinephrine hydrochlorideb). Atropine sulfatec). Sodium chloride

14

d). Platyphyllini hydrotartrase). Anaprilinum2. A patient suffering from allergic rhinitis was prescribed ephedrine in form of nasal drops. Thepatient has significantly benefited from nasal instillation, and this stimulated him to use the drugevery 2 hours. But under these conditions the drug appeared to be ineffective. What is the mostlikely cause of this phenomenon? a). * Tachyphylaxisb). Allergyc). Idiosyncrasyd). Cumulatione). Drug depence

10. SalbutamolTests

1. A patient with bronchial asthma takes preparation from the group of beta-adrenergic agonists.Name this preparation. A Salbutamol B Doxazozin C AceclidinD Atropine sulfateE Metoprolol2. To the patient with bronchial asthma for the removal of attack β-adrenoceptor agonist wasprescribed. Name this preparation. A Salbutamol B Adrenaline hydrochlorideC DroperidolD ClofelinE Isadrin3. A woman of 30 years old, with the threat of abortion was injected Salbutamol which reducedcontractive activity of myometrium. What is the mechanism of action of this preparation?A Stimulation is a beta-2-adrenoreceptorsB Stimulation of alfa-adrenoreceptors C Blockade is a beta-1- adrenoreceptorsD Blockade of monoaminoksidases E Blockade of phosphodiesterases4. A patient was prescribed a medicine from β2-adrenoceptor agonist to treat bronchial asthma.Choose this medicine:a) Salbutamolb) Diazepamc) Doxycycline hydrochlorided) Nitroglycerine) Digoxin5. A patient who has a bronchial asthma was prescribed salbutamol after which signs of spasm havedisappeared. It is connected with the stimulation of:a) *β2-adrenoreceptors b) α1 – adrenoreceptorsc) M - cholinergic receptord) acetylcholine synthesise) β1 – adrenoreceptors6. A patient with bronchial asthma was prescribed salbutamol that has led to relief of bronchospasmsymptoms. This is associated with stimulation of:a). β1- adrenoreceptors

15

b). *β2- adrenoreceptorsc). α1- adrenoreceptorsd). Acethylcholine synthesise). Muscarinic cholinoreceptors7. When fenoterolum for inhaletions is not available in a pharmacy, it can be substituted by thefollowing drug from the group of bronchoselective beta-2-adrenomimetics:a)* Salbutamolum b) Ephedrinumc) Metacinumd) Euphyllinume) Isadrinum8. А patient with bronchial asthma has been administered а drug from the group of beta-adrenergic agonists. Specify this drug:А. NitroglycerineВ. Doxycycline hydrochloride C. *SalbutamolD. DigoxinЕ. Diazepam

11. Propranolol (Anaprilin)Tests

1. Give an advice to patient with bronchial asthma and diagnosis as hypertensive patient. Specifyhypertonic preparation, which causes side effect to that patient. A PropranololB DrotaverinC PrasosinD Magnesium sulfasE Lysinopril2. At the farmacy a drugstore manager asks a pharmacist: which of the remedy are used fortachyarrhythmia treatment?a) Propranololb) Enalaprilc) Adrenalind) Proserine) Atropine3. To treat extrasystolia nonselective β1, β2-adrenoceptor antagonist was used. What is the name ofthis medicine?a) propranololb) atenololc) phentolamined) prososine) reserpine4. A patient with essentional hypertension the drug from nonselective beta-adrenoceptor antagonistswas prescribed. Name this preparation: A *Anaprilin B Prazozin C ProzerinD Adrenaline hydrochloride E Labetalol5. А 60-year-old patient has essential hypertension stage II, coronary disease, bronchial asthma.After pharmacotherapy correction the patient exhibited a bronchospastic attack, intensified dyspnea.What drug provoked this complication?

16

a)* Propranololb) Salbutamolum c) Nifedipined) Euphyllinume) Mucaltinum6. A 52-year-old patient complains on having increased arterial pressure for a month. She has a 5-year history of bronchial asthma. What group of hypotensive drugs should NOT be recommended tothe patient?a). * Beta-adrenoreceptor blocadeb). Angotensinic receptors blocadec) Calcium channel blockersd) Diureticse) Tranquilizers

12. MetoprololTests

1. To a patient with an angina pectoris Metoprolol was prescribed. What pharmacological effect ofthis preparation is used for treatment of angina pectoris? A AntianginalB HypotensiveC AntiarhythmicalD AntiaggregaticE Broncholytic2. To the patient of 56 years old with ischemia of heart metoprolol was prescribed . Whatmechanism of beta-adrenoblockers actions used for treatment of on this disease? A Increase of oxygen consumption by myocardiumB Increase the requirement of myocardium in oxygenC Extend coronal vesselsD Diminish tone of peripheral vesselsE Narrow coronal vessels3. To the patient with hypertension for decrease of blood pressure metoprolol was prescribed. Whatis mechanism of action of this preparation:A Blocking of beta-adrenoreceptorsB Blocking of alfa-adrenoreceptorsC Indirect adrenomimetic actionD Spasmolytic actionE Blocking of angiotensin receptors4. Hypertensive patient has been prescribed medicine from beta- adrenergic receptor blockers fordecrease of blood pressure. Name that medicine/A MetoprololB Magnesium sulfateC EnalaprilumD Potassium losortanE Reserpine5. A patient is prescribed metoprolol to treat hypertension blood pressure has singnificantly reduced.What mechanism of antihypertensive action does this medicine have?a) selective blockade of β1 – adrenoreceptors; b) selective blockade of α1 – adrenoreceptors;c) blockade of angiotensin converting enzyme;d) suppression of angiotension receptors;e) suppression of calcium channel6. A patient with hypertension was administered metoprolol for the arterial pressure reduction. What

17

is its mechanism of action?a). * Beta adrenoreceptor blocadeb). Angotensinic receptors blocadec). Inderect adrenomimetic actiond).Antispasmodice). Alfa adrenoreceptor blocade

13. Sodium valproateTests

1. A child who has epilepsy takes sodium valproate. What mechanism of action has this medicine?a) GABA accumulationb) blockade of benzodiazepine receptorsc) blockade of Ca2+ canalsd) blockade of K+ canalse) reduction activity of GABA

14. NitrazepamTests

1. A woman suffering on a neurosis sleeps badly. What preparation is better to use for treatment ofinsomnia?A NitrazepamumB PhenobarbitalC Sodium pentobarbitalD BromisovalumE Tincture of valerian2. A man of 55 years old complains of insomnia, excitement, restless. What drug should beprescribed in this case?A NitrazepamB AminazineC Triftazine D DroperidolE Amitriptilin3. A woman after the carried stress sleeps badly. What hypnotic preparation is better to prescribe fortreatment of insomnia?A NitrazepamB Phenobarbital C Chloralhydrate D Aminazine E Barbital 4. Choose a sleeping draught for a patient who has sleep disturbance caused by neurosis – like state,high petulance.a) Nitrazepamb) Phenobarbitalc) Zopiclond) Metaqvalone) Zolpidem

15. PhenazepamTests

1. A patient who has been taking phenazepam for a month came to a pharmacy. He insisted onbuying another two packs of this drug. According to the patient, he feels unwell without

18

phenazepam. What is the mechanism of the developed side effect?a)* Addiction (Drug dependence)b) Absorption process reductionc) Idiosyncrasyd) Cumulatione) Aftereffect syndrom

16. PhenobarbitalTests

1. A patient suffering from epilepsy has taken Phenobarbital for a long time and developed drugtolerance. What is the mechanism of this phenomenon development?a)*Accelaration of biotransformationb) Substances accumulation in the bodyc) Absorption process reductiond) Inhibition of biotransformatione) Receptor’s sensitivity enhancement2. A patient who has taken phenobarbital for а long time was prescribed diclofenac sodium.However the anti-inflammаtоry effect of diclofenac appeared to bе less than expected due to thepharmacokinetic interaction of these drugs. Such interaction might bе the result of the followingprocesses:А. Change of receptor sensibility B. Delerated drug metabolism in liver С. Accelerated drug metabolism in liver D. Reduced protein concentration in рlasmaE. Increased drug dosage

17. LevodopaTests

1. A patiend with Parkinson΄s disease was prescribed preparation affecting the dopaminergicsystem. Name this preparation:A LevodopaB Zopiclon C Droperidol D Aminazine E Lorazepam2. To a patient with parkinsonism for the removal of muscular rigidity the dopaminergic drug wasprescribed. Name this preparation.A LevodopaB Aminazine C ParacetamolD Scopalamine hydrobromideE Atropine sulfate3. What preparation should be prescribed to treat Parkinson's disease?A LevodopaB NitrazepamC AminazineD ProserinE Morphine

18. MorphineTests

1. A patient has cancer to lungs, which is accompany to sharp pain and cough. What analgetic19

remedy is reasonable to use?a) Morphine hydrochlorideb) Analginec) Glaucined) Libexine) Paracetamol2. To narcological department a patient was delivered. His diagnosis was morphine dependence.The doctor noted decreasing of morphine pharmacological activity. What is the name for thephenomenon when the effectiveness of drug reduces after repeated introduction?a) get used to drugb) material cumulationc) functional cumulationd) antagonisme) summation

19. Promedol (Trimeperidine)Tests

1. Pregnant woman during childbirth has weak uterine contraction and strong pain symptom. Whichdrug is it necessary to prescribe in this case?A PromedolB Morphine hydrochlorideC AnalginD Diclofenac SodiumE Fentanil2. Help a doctor to choose narcotic analgesic which can be used for anaesthetizing of births?A PromedolB Paracetamol C Codeine phosphate D Fentanyl E Analgine3. Emergency was called to a patient of 45 who has renal colic. Which medicine of 5 narcoticanalgesics should one prefer?a) promedolb) morphinec) tramadold) phentaline) oxeladin

20. NaloxoneTests

1. To emergency department a patient in the comatose state was hostitalized, who had aconsiderable hypotension, bradycardia, hypothermia, anury, Cheyne-Stokes breathing. A diagnosisis set: poisoning Morphinum. Recommend to a doctor some antagonist of morphinum for theleadthrough of antidotnoy therapyA NaloxoneB PentazocinumC Nalorfinu hyrochlorid D Kordiamine E Lobeline2. A patient has acute poisoning by Morphine. What preparation is it needed to uset as an antidote?A NaloxoneB Lobeline

20

C BemegrideD Atropine sulfateE Unithiol3. A woman of 25 was injected naloxone to prevent an acute morphine intoxication. Naloxone fastymade her condition better. What is the mechanism of action of this medicine?a) blockade of opiod receptorsb) blockade of GABA’s receptorsc) blockade of serotonin receptorsd) blockade of dopamine receptorse) blockade of benzodiazepine receptors4. What is remedy should be used in case of narcotic analgetic overdose as an antidote to stoprespiratory center depression?a) Naloxoneb) Cordiaminc) Etymisold) Camphore) Paracetamol5. Explain to your pharmacist – colleague. What indications does naloxone have?a) acute narcotic analgesic poisoningb) heavy metal poisoning c) cardiac glycoside poisoningd) ergot alkaloid poisoninge) atropine sulfate poisoning6. А 25-year-old woman presenting with acute morphine intoxication was given an injection ofnaloxone that caused rapid improvement of her condition. The mechanism of action of thispreparation is based on the block of the following receptors:a)* Opioid receptors b) Serotonin receptorsc) GABA- receptorsd) Dopaminee) Benzodiazepine receptors7. А patient presents with morphine intoxication. Which drug should bе injected as an antidote? А. UnithiolA. NaloxoneB. Lobeline hydrochloride C. Atropine sulphateD. IbuprofenE. Bemegride8. What naloxone indications are there?A. *Narcotic analgetics acute poisoningB. Heavy metals poisoningC. Cardiac glycosides poisoningD. Ergot alkaloids poisoningE. Atropine sulphate poisoning

21. ParacetamolTests

1. You are an employee of pharmacy storage. By entry into the list of new preparations in acomputer database specify to what pharmacological group paracetamol belongs to.A Nonarcotic analgesic B Sleeping-pills C Diuretic agents

21

D HypotensorsE Antianginal drugs2. The child of 10 years old with an acute respiratory viral disease was prescribed paracetamol fordecrease of fever. What type of pharmacotherapy is it?A SymptomaticB Etiotropic C NosotropicD AdaptationE Substitutive3. Patient consulted a pharmacist. He had a gastric ulcer and headache. Which of analgetics is thebest for the patient?a) Paracetamolb) Acetylsalicylic acidc) Indometacind) Diclofenac sodiume) Ibuprofen4. Majority of non-narcotic analgesics have also anti-inflammatory and antipyretic effects. Which ofthe remedy does not have anti-inflammation effect?a) Paracetamolb) Diclofenac sodiumc) Acetylsalicylic acidd) Indometacine) Celeckoxib5. A child who has a respiratory disease was prescribed paracetamol to reduce hyperthermia. Whatpharmacological group does this medicine belong to?a) nonnarcotic analgeticb) antihypertensive drugc) antiacidd) diuretic agente) antitussive drug6. You are pharmacist at a drugstore. Offer an equivalent for temporary unavailable paracetomol.a) panadolb) aspirinc) analgind) pyroxicame) celecoxib7. You are employed in a pharmaceutical storehouse. When adding newly received preparations tothe computerized database, specify the pharmacological group of paracetamol:a). * Nonnarcotic analgetic b). Antianginal drugc). Hypnoticd).Diuretice). Hypotensive drug8. A 26-year-old pregnant woman (III trimester of pregnancy) complains about body temperaturerise up to 39 ºC. What febrifuge may be recommended in this case?a)* Paracetamolb) Indometacinc) Diclofenacd) Aspirine) Analgin9. Mother of a 2-month-old child came to a pharmacy and asked for a febrifuge. What drug shouldbe recommended for the child?

22

a)* Paracetamol b) Acetylsalicylic acidc) Nimesulided) Indometacinume) Diclofenac sodium10. А woman in the III trimester (pregnanсу has an acute respiratory viral disease accompanied withbody temprature risе up to 39. Which of the drugs should bе recommended?А. Acetylsalicylic acidВ. ParacetamolC.1ndomethacinD. Diclofenac sodiumК. Celecoxib11. The student with cold has been prescribed antipyretic medicine. Name this medicine.A. *ParacetamolB. Ascorbic acidC. OxytocinD. FamotidineE. Cyanocobalamin

22. Diclofenac sodiumTests

1. For a patient of 55 years old on the 4th day of treatment with diclofenac sodium there was thegastric bleeding as a result of gastric ulceration. What is the ulcerogenic effect of preparation relatedto?A Diminishing of formation of prostaglandin E2 B Diminishing of formation of leucotriens C Blocking of of phosphodiesterase enzymeD Diminishing of formation of red blood cells E Diminishing of formation of leucocytes2. Answer the patient’s question, what contraindication Sodium diclofenac has?A gastric ulcerationB bronchitisC angina pectorisD diabetes mellitusE high blood pressure3. What is elementin mechanism of sodium diclofenac action?A Blocks COX-2B Activation of phosphodiesterases synthesisC Inhibition cholinesteraseD Activation adenilatcyclasesE Depression of phosphodiesterase4. Patient’s diagnosis is ankylosing spondylitis. The doctor prescribed him nonsteroidantiinflammatory medicine - diclofenac sodium. Point out the mechanism of analgesic action of theagent.a) blockade of COX-1and2b) blockade of COX - 2c) blockade of phosfolipase A2

d) blockade of opioid receptorse) stimulation of opioid receptors

23

23. Acetylsalicylic acidTests

1. Find in your pharmacy drug for treatment headache also hawing antiagregant effect.A Acetylsalicylic acidB Codeine phosphate C PromedolD Tramadol E Fentanyl2. To a patient after the acute cardiac infarction a doctor recommend used acetylsalicylic acid during 3-4 months. What effect acetylsalicylic acid is used in such f case.A AntiaggregantB AntipireticC AnalgesicD AntiinflammatoryE Spasmolytic3. It was prescribe acetylsalicylic acid for 100 mg one for day to patient who has got myocardialinfarction. What kind of aspirin effect did doctor expect? A antiaggregantB against inflammationC antipyretic actionD analgesicE vasodilatory action4. What effect expects a doctor, when prescribing Aspekard (acetylsalicylic acid) - to a patient whoa) has CHD (coronary heart disease)b) antiaggregantc) analgeticd) antipyretice) anti – inflammationf) cholagogic5. What a pharmacological effect of acetylsalicylic acid allows to use it for prevention ofthromboses when one has coronary heart disease.a) antiaggregantb) analgesicc) anti-feverd) ulcerogenic actione) antiinflammatory6. To prevent thrombosis combineol to angina pectoris a medicine from nonsteroid anti –inflammatory group was prescribed.a) aspirinb) ibuprofenc) pyroxicamd) mefenamic acide) indometacin7. Which of the below-listed drugs is used for thrombolytic therapy in case of myocardialinfarction?a). * Acetylsalicylic acidb). Ticlopidinec). Streptokinased).Phenylinume). Heparinum8. А patient consults а pharmaceutist about taking acetylsalicylic acid as an antiaggregant. What is the daily dose that should bе recommended for continuous usе?

24

А. 1,0-2,0 g В. 0,5-1,0 g С. Over 4,0 g D. 2,0-3,0Е. 0,1-0,3 g . 9. A 52-years old patient had myocardial infarction and was discharged from the hospital after the stationery treatment. What daily dose of acetylsalicylic acid should be administered in order to prevent thrombosis?A. 100 mgB. 50 mgC. 1000 mgD. 200 mgE. 500 mg10. A patient with stenocardia has been administered acetylsalicylic acid for:A Antiplatelet effectB Inhibition of blood fibrinolytic activityC Aggregate effectD Anti-inflammatory effectE Increase in blood fibrinolytic activity

24. CelecoxibTests

1. А 40-year-old female patient was diagnosed with rheumatoid arthritis; She has also a history ofstomach ulcer. What drug from the group of nonsteroid anti-inflammatory drug may berecommended this patient?a)* Celecoxibb) Aspirinc) Mefenamic acidd) Indometacine) Diclofenac2. It is necessary to prescribe non-steroid anti-inflammatory drug for patient with rheumatoidarthritics and concomitant duodenal ulcer. Which drug is the drug of choice in this case?a)*celecoxibb) acetylsalicylic acidc) paracetamold) analgine) diclofenac sodium3. Which anti-inflammatory drug is the less harmful for the stomach and can be recommended to apatient with exacerbation of rheumatoid arthritis?a). * Celecoxibb). Diclofenac sodiumc). Ibuprofenumd).Indometacinume). Acetylsalicylic acid4. А 57-year-old female patient was diagnosed with rheumatoid arthritis; she has also а history ofstomach ulcer. What drug from the group of nonsteroid anti-inflammatory drugs mау bеrecommended this patient?А. Indometacin В. DiclofenacС. CelecoxibD. AspirinЕ. Mefenamic acid

25

25. MeloxicamTests

1. A pharmacy received new generation nonsteroid anti-inflammatory drug “meloxicam” thatmainly blocks cyclooxygenase-2. What advantages does this preparation have in comparison withother nonsteroid anti-inflammatory drug?a)* Minimal side effect on alimentary tractb) Evident myospasmolytic actionc) Interferonogenic propertiesd) Significant inhibition of protease activitye) Minimal side effect on hematogenesis

26.PiroxicamTests

1. Which of the following non-steroid anti-inflammatory agents has the least harmful effect on the mucosa of the gastrointestinal tract?A. Acetylsalicylic acidB. PiroxicamC. IndomethacinD. DiclofenacE. Nimesulide

27. IndometacineTests

1. On the 4th day of treatment with indometacin a 55-year-old patient developed gastrorrhagia as aresult of gastric mucosa ulcer. Ulcerogenic effect of this drug is explained by the lowered activity ofthe following enzyme:a). *Cyclooxygenase-1 (COX-1)b). Prostacyclin sisntetazac). Tromboxanetin sisntetazad). Cyclooxygenase-2 (COX-2)e). Lipooxygenase (LOG)

28. NimesulideTests

1. Which of the following non-steroid anti-inflаmmаtоrу agents has the least harmful effect оn the mucosa of the gastrointestinal tract?A. NimesulideВ. IndomethacinС. PiroxicamD. DiclofenacЕ. Acetylsalicylic acid

29. Aminazine (Chlorpromazine)Tests

1. For a woman of 58 years old, that is on treatment in a psychiatric department after the injection ofthe prescribed preparation a blood pressure decreased very much. Which preparation may cause thisreaction? A AminazineB Caffeine- Sodium benzoateC Imizinum D Amitriptilin E Adrenaline hydrochloride

26

2. To the patient with a psychosis, it was prescribed neuroleptic with a psychosedative effect. Whatpreparation is it? A AminazineB DiazepamC Caffeine Sodium benzoateD NitrazepamE Aethymizol3. To stop the delirium and hallucinations in a schizophrenic patient a doctor used aminazine. Whatis the mechanism of antipsychotic action of this medicine?a) inhibition of dopaminergic processes in the CNS b) stimulation of adrenergic and dopamine processes in CNSc) stimulation of cholinergic processes in CNSd) blockade of cholinergic processes in CNSe) inhibition of МАО4. A patient who has schizophrenia is prescribed neuroleptic. Which of medicines listed belongs tothis group?a) aminazineb) celecoxibc) propranolold) promedole) pyracetam5. You are the pharmacist taking an intership. When taking a test choose from pharmacologicaleffect listed that allows to use aminazine to treat psychosis.a) antipsychoticb) hypothermicc) antiinflammatoryd) antiemetice) spasmolytic6. A patient that has delirium was prescribed an antipsychotic agent. What is the name for thismedicine?a) aminazinb) diazepamc) ciclodold) caffeinee) phenobarbital7. A patient with schizophrenia has been administered a neuroleptic. Which of the listed drugs fallinto this group?a) Aminazineb) Pyracetamc) Propranolold) Celecoxibe) Morphine

30. DiazepamTests

1. To the patient who is suffering of a neurosis with anxiety and fear a doctor prescribed diazepam.What pharmacological effect of preparation allows to use it for treatment of this disease?A anxiolyticB antiarrhythmicC antiiflammatoryD hypotensiveE antianginal

27

2. To the patient with a neurosis a tranquilizer was prescribed, which is derivative ofbenzodiazepines. Name this preparation. A DiazepamB Atropine sulfate C Pyroxicam D ParacetamolE Cyclodolol3. Woman asked to doctor with high irritability, restlesness sensibility. Patient was prescribedmedicine from tranquilizer group. A DiazepamB CaffeineC AminazineD AmitriptylineE Tramadol4. Due to what pharmacological effect is diazepam used to treat neurosis?a) anxiolytic effectb) analgesic effectc) diuretic effectd) antipyretic effecte) antidepressant effect5. Fear, psychic tension made it possible to select medicine which reduces these symptoms inpatient who has neurosis.a) diazepamb) lithium carbonatec) sydnocarbd) nootropile) caffeine6. A patient of 30 has somnopathy and disequilibrium psychoemotional sphere was prescribeddiazepam. What is the cause of psychosedative effect of the medicine?a) activation of GABA’s systemb) limbic system inhibitionc) reticular formation inhibitiond) reduction number of noradrenaline in the CNSe) opioid receptor inhibition7. A patient suffering from neurosis accompanied by anxiety and fear was prescribed diazepam.What pharmacological effect makes it possible to apply the drug for this disease treatment?a). * Anxiolyticb). Hypotensivec). Antiarrhythmic d). Antianginale). Anti-inflammatory8. A 30-year-old patient with a sleep disorder and psychoemotional disbalance had beenadministered diazepam. What is the mechanism of its psychosedative action?a) activation of GABAergic systemb) inhibition of limbic system c) inhibition of reticular formation d) reduction of noradrenaline amount in the CNSe) inhibition of opioid receptors

31. DroperidolTests

1. A doctor-anaesthetist should perform an operation with using neuroleptanalgesia. What drug

28

combinations should be used in this case?A Fentanil with droperidolB Droperidolum with prednisoloneC Fentanil with diazepamD Diazepam with aminazineE Promedol with amitriptilin2. A patient is in special care ward because of myocardial infarction. Acute pain syndrome makesthe doctor to use neuroleptanalgesia. What neuroleptic is used in this case of anaesthesia?a) droperidolb) corliconc) lozartand) tramadole) amitriptyline3. An anaesthesiologist has to perform an operation under neuroleptanalgesia. Which of the following drug combinations should bе used in this case?A. Diazepam with aminazineB. Fentanyl with diazepamС. Droperidol with prednisoloneD. Fentanyl with droperidolE. Promedol with amitriptillin

32. Caffeine sodium benzoateTests

1. A diagnosis is a migraine. Doctor prescribed preparation from the group of purines. Whatpreparation was prescribed to a patient?A Caffeine-benzoate Sodium B Phenazepamum C TheophyllinumD PentocxyphyllinE Dimedrol2. What reasonable rout of administration for sodium caffeine benzoate should one choose to treatmigraine? Select from the listed below.a) peroralb) intra-arterialc) inhalationd) transdermale) rectal

33. AmitriptylineTests

1. А patient with depression has bееn administered а drug from the group of tricyclicantidepressants. Specify this drug: А. Amitriptyline В. PhenazepamС. CaffeineD. AminalonumЕ. Droperidol

34. AcetylcysteineTests

1. Advise to a patient with a acute bronchitis mucolytic preparation which relieves expectoration.A Acetylcysteinum

29

B Glaucin C Loratidin D Diclofenac sodiumE Drotaverine hydrochloride2. A mucolytic drug was prescribed for treatment patient with a acute bronchitis. Name thispreparation. A AcetylcysteinB GlaucinC Codeine phosphate D Aethimizol E Bemegride3. A patient has chronic bronchitis and cardiovascular insufficiency, which need long termapplication of expectorant drugs and hearty glycosides. What artificial sulfur containing mucolyticshould one choose for relief (prevention) of possible intoxication which could be caused by heartyglycosides?a) Acetylcysteineb) Bromheksinc) Ambroksold) Lazolvane) Myckaltin4. Recommend а patient with acute bronсhitis а mucolytic drug that facilitates expectoration:A. AcetylcysteineВ. LoratadineС. Drotaverine hydrochlorideD. Diclofenac sodiumЕ. Glaucine

35. GlaucinTests

1. A 34-year-old patient suffering from bronchitis was prescribed an antitussive drug of centralaction. What drug is it?A *Glaucin B Corglycon C Enalapril D Furosemide E Fercoven2. A patient has acute laryngotracheitis and dry, unproductive cough which exhausts him much. Ananticough is prescribed. Define this medicine.a) *Glaucinb) Ambroksolc) Acetylcystaind) Mycaltine) Infusion from grass Thermopside3. Selling glaucine hydrochloride to a patient who has chronic bronchitis about what side effectshould you warn him?a) *reduction of central blood pressure;b) stimulation of central nervous system;c) abnormalities of cardiac rate;d) increase of ocular pressure;e) allergic reactions4. Advise family doctor what plant origin antitussive drug is better to prescribe to a patient who hasdry cough, rised blood pressure.

30

a) *glaucineb) libexenc) bromhexined) ambroxole) oxeladin5. A patient with chronic bronchitis wants to buy glaucine hydrochloride at a pharmacy. Whattypical side effect of the drug shoud the patient be warned about?А. *Drop of arterial pressureB. Allergic skin rashС. Rise of intraocular pressureD. Irregular heartbeatЕ. Excitation of the central nervous system 6. A patient with chronic bronchitis gets glaucine hydrochloride at a pharmacy. The patient must be warned about the following typical side effect of this drug?A. *Arterial pressure dropB. Increased intraocular pressureC. Irregular heartbeatD. Excitation of the central nervous systemE. Allergic skin rash7. A pharmacy dispenses glaucine hydrochloride to a patient with chronic bronchitis. The patientmust be warned about the following typical side effect of the drug:A *Blood pressure fallB Excitation of the central nervous systemC ArrhythmiaD Rise of intraocular pressureE Allergic skin rash8. Pharmacy sells glaucine hydrochloride to the patient with chronic bronchitis. What common side effect should he be warned about?A. *Decrease of arterial pressureB. Excitation of central nervous systemC. Disruption of cardiac rateD. Increase of intraocular pressureE. Allergic skin rashes

36. AmbroxolTests

1. A 46-year-old patient suffering from chronic bronchitis came to a pharmacy. What expectorativedrug may be recommended? a). * Ambroxolb). Falimintc). Libexind).Glauvente). Salbutamol

37. TheophyllineTests

1. A 67-year-old patient who undergoes treatment for bronchial asthma presents with limb tremor,headache, insomnia, extrasystole. What drug might have caused such symptoms?a). * Theophylline b). Tavegylc). Acetylcysteined). Prednisolone

31

e). Intal

38. Cromoline sodiumTests

1. Which of the following is the drug of choice for bronchial asthma attacks prevention? a)* Cromolyn sodiumb) Dyphenhydramine hydrochloridec) Salbutamold) Ambroxole) Drotaverine

39. DigoxinTests

1. A patient with stagnant chronic cardiac insufficiencya a doctor prescribed cardiotonic agent fromthe group of cardiac glycoside, which is produced in ampoules and pills. What preparation is it?A DigoxinB StrophanthinC KorglyconD DigitoxinumE Dobutaminum2. A man of 60 that suffers on chronic cardiac insufficiency, with complaints about tahyarrhythmiacame to the pharmacy. Name preparation for rhythm correction.A DigoxinB Riboxin C SpironolactonumD Acetylsalicylic acidE Asparkam3. To a patient with chronic cardiac insufficiency it was prescribed as cardiac glycoside from thegroup of foxglove containing drug. Name this preparation. A Digoxin B Strophanthin C CardiovalenD Korglykon E Cordiamin4. Patient with chronic cardiac failure was prescribed digoxin. What kind of side effect thismedicine has?A BradyarrhythmiaB HyperpotassemiaC OtotoxicityD HydruriaE Dermatitis5. Pharmacy visitor by following his prescription to treat chronicle impaired cardial function hasbought digoxin and asparkam. Explain visitor meaning of such kind of combination.A For the prophylaxis of kaliopeniaB For the increase of content of ions of calciumC For warning of giponatriemiiD For strengthening of cardioactive action of digoksinE For the acceleration of digitalization6. A patient who has chronic heart failure was prescribed a cardiac glycoside from a foxglovemedication group. What is the name of this medication?a) digoxinb) lysinopryl

32

c) dobutamined) furosemidee) phebophibrat7. A patient with chronic heart failure was prescribed a cardiotonic with middle-term effect.a) digoxinb) athenololc) strophanthined) verapamile) nitroglycerine8. A patient suffering from chronic cardiac insufficiency was prescribed a cardiac glycoside fromthe group of foxglove (Digitalis) drug. What drug is it? a). * Digoxin b). Strophanthine c). Cardiovalend). Corglycon e). Corvalol9. A 67-year-old patient with chronic heart failure takes digoxin. In order to reduce its side effectsthe patient's doctor recommended to combine it with the followig drug: A *Раnangin B Calcium gluconate C Еuphyllinum D Hydrochlorthiazide E Calcium chloride

40. DigitoxinTests

1. During digitoxin therapy for chronic cardiac insufficiency, a patient developed signs ofintoxication with this preparation. The patient was prescribed unithiol action on case of intoxicationwith cardiac glycosides? a)* Reduction of K+-, Na+ - adenosine triphosphataseb) Binding of glycoside into the complex compoundc) Increase of sodium concentration in the cardiomyocytesd) Increased potassium permeability in the cardiomyocytese) Biding of calcium ions

41. CorglyconTests

1. After extraction of tooth a patient had acute cardiac insufficiency. What preparation should beinjected?A CorglyconB BemegrideC AethimizolD Cavinton E Pyracetam2. To a holiatry of a patient who has cardiopulmonary decompensation and increasing symptoms ofpulmanary edema was prescribed a powerful cardiotonic agent of a short – term effect.a) corgliconb) propranololc) dipiridamold) athenolole) nitroglycerine3. A patient has an acute cardiovascular insufficiency. Choose a cardiac glycosides with the fastest

33

cardiotonic effect.a) Corliconb) Digitoxinc) Digoxind) Celanide) Adonisid

42. DobutamineTests

1. To the patient with acute cardiac insufficiency and intolerance to cardiac glycosidеs. Dobutaminewas injected. What is the mechanism of action for this preparation?A Stimulation of beta1- adrenoreceptorsB Stimulation of alfa-adrenoreceptorsC Blockade of K+, Na+-ATP-aseD Oppressing of activity of phosphodiesterase enzymE Stimulation of M-cholinoreceptors2. A patient with acute cardiac insufficiency and cardiac glycosidеs intolerance got an injection ofdobutamine. What is the mechanism of its action?a). *Stimulation of β1- adrenoreceptorsb) Stimulation of α1-adrenoreceptorsc) Blockade of K+, Na+-adenosine triphosphatased) Inhibition of phosphodiesterase activitye) Stimulation of muscarinic cholinoreceptors3. Dobutamine has been administered to the 49-year-old-patient with acute cardiac failure andcardiac glycoside intolerance. What is this drug's mechanism of action?A. Stimulation of β1-adrenoreceptorsB. Stimulation of α1-adrenoreceptorsC. Blockade of K+-, Na+-adenosinetriphosphataseD. Suppression of phosphodiesterase activityE. Stimulation of M-cholinergic receptors

43. NitroglycerineTests

1. For rapid relief of symptoms of stenocardia a patient takes nitroglycerine in capsules. What is themost rational rout administration for this preparation?A SublingualB OralC RectalD InhalationE Hypodermic2. A patient who has ischemic heart disease was prescribed a sublingual medication to suppress astenocardia attack. Point on this medication.a) nitroglycerineb) corglyconc) isosorbide mononitrated) lysinoprile) amiodaron3. Which of medicines listed below in case of sublingual usage up spress fastly anginal attack?a) Nitroglycerineb) Digoxinc) Amyodarond) Lysinopronil

34

e) Corglycon4. A man of 50 had anginal attack. A doctor advised him to put a nitroglycerine pill sublingually.Why is it recommended to use nitroglycerine sublingually?a) action starts much faster;b) activated by saliva;c) ruined by gastric juice;d) is badly absorbed in bowels;e) is fastly biotransformed in liver5. In order to arrest stenocardia attacks a patient takes nitroglycerin capsules. What is the rationalway of the drug introduction? a)* Sublingual b) Hypodermicc) Inhalationd) Rectale) Peroral6. After аn emotional stress а 60-year-old patient presented with chest pain irrаdiаting to the leftarm. Specify а drug thаt relieves pain in this case:A. NitroglycerineB. PropranololС. MetoprololD. DiltiazemЕ. Nifedipine

44. Isosorbide mononitrateTests

1. To the patient suffering on the attacks of stenocardia drug from group of nitrates prescribes.Name this preparationA Isosorbide mononitrate B Diazepam C Aminazine D Levodopa E Prozerin2. Advise a patient who comes at your drugstore a medication for anginal attack prevention.a) isosorbide mononitrateb) corglyconc) dobutamined) diazepame) magnesium sulfate3. After a long-term intake of isosorbide to prevent anginal attack a patient noticed significant effectof the lash. What is the name for this phenomenon.a) toleranceb) cumulationc) physical dependenced) allergye) potentiation4. A patient has been taking isosorbide for stenocardia prevention for quite a long time. Now henotes a significant decrease in the affect of the drug. What is this phenomenon called?A. AllergyB. ToleranceC. PotentiationD. CumulationE. Physical dependence

35

45. AmiodaronTests

1. Tachiarrythmia emerged in patient’s postinfarction period. Cardiologist prescribed amiodaron.Designate mechanism of action of the medicine.a) blockade potassium canalsb) blockade calcium canalsc) blockade β1 – adrenoreceptors of heartd) blockade magnesium canalse) blockade sodium canals

46. MolsidomineTests

1. 6 month after treatment a patient with coronary heart disease developed tolerance to the nitrateswith prolonged action. What drug with nitrate-similar effect should be recommended in this case?a). * Molsidomine b). Verapamilc). Nifedipined). Metoprolole). Prasosine

47. PananginTests

1. A 68-year-old female patient has been continuously taking furosemide for heart failure treatment.What drug should be administered?a). * Pananginb). Midronatumc). Atp-longd).Sustac fortee). Trimetazidine2. А 67-year-old patient with chronic heart failure takes digoxin. In order to reduce its side effectsthe patient’s doctor recommended to combine it with the following drug:a). * Pananginb). Euphyllinumc). Calcium gluconated). Calcium chloridee). Hydrochlorthiazide

48. VerapamilTests

1. What drug may cause constipation in a patient undergoing combine therapy for arterialhypertension?a). * Verapamilb). Furosemidec). Acetylsalicilic acid in small dosegesd). Trimetazidinee). Panangin

49. LisinoprilTests

1. A patient was warned about hypotensive drug, which can provoke a cough as a side effect. Namethis preparation. A LisinoprilB Clofelin

36

C PhenihydineD DichlotiazideE Metoprolol2. A patient who has a renal hypertension was prescribed a hypotensive agent from the angiotensiveconverting enzyme blocker group.a) lysinoprilb) anaprilinc) nitroglycerined) papaverinee) nifedipine3. You are a pharmacist at a drugstore. Choose an angiotensinconverting enzyme inhibitor.a) lysinoprilb) lozartan c) clonidined) propranolole) amlodipin4. Advise a doctor. Which of remedy are reasonable to be prescribed to a patient who has essentialhypertension if he has bronchial asthma and hyperactivity of renin-аngiotensin system.a) Lysinoprilb) Reserpinec) Dibasold) Papaverinee) Nifedipine5. A doctor prescribed Lysinopril to a patient with hypertension. What mechanism of action doesthis preparation have?A Blocks ACEB Blocks α- adrenoceptorsC Bloks β-adrenoceptorsD β-adrenoceptors stimulatesE M-cholinoceptors blocks6. To the patient with morbus hypertonicus it was prescribed lizinoprilum. What typical side effectdoes this drug have?A Dry cough B ConstipationC Increase of appetite D Insomnia E Vomiting7. A patient was warned that taking the prescribed preparation might cause cough. What drug is it?a)* Lisinoprilb) Clonidinec) Phenihydined) Dichlotiazidee) Metoprolol8. A patient suffering from hypertension consulted a doctor about dry cough that was presumablyprovoked by antihypertensive therapy. What antihypertensive drug had she been taking?a). * Lisinoprilb). Atenololc). Nifedipined). hydrochlorthiazidee). Furosemidum9. A patient suffering from essential hypertension has increased concentration of renin in bloodplasma. Which pharmacological group should be preferred for this patient treatment?

37

a). * ACE inhibitorsb). α-adrenoblockersc) Blockers of calcium channeld) Diureticse) Sympatholytics

50. EnalaprilTests

1. A patient with hypertension had a dry cough on a background the systematic reception ofhypotension preparation. What preparation can cause such side action?A EnalaprilB Magnesium sulfateC AnaprilinD PrazozinE Reserpine2. A 24-year-old patient haws been suffering for diabetes mellitus type I for 8 year. Diabeticnephropathy provoked development of symptomatic arterial hypertension. Which of the followingdrugs is indicated for long-term therapy?a). * Enalaprilb). Clonidinc). Dibazold).Dichlothiazidee). Propranolol3. А patient with hypertension has been administered оnе of antihypertensivе drugs. Blood pressure dropped back to normal, but the patient has developed а persistent dry cough. Which of the following drugs has such а side effect?А. PropranololВ. FurosemideC. NifedipineD. Enalapril maleate Е. Clonidine4. A 24-years old patient has been suffering from diabetes mellitus type I for 8 years. Diabeticnephropathy provoked development of symptomatic arterial hypertension. Which of the followingdrugs is indicated for long-term therapy?A. DichlothiazideB. ClonidinC. PropranololD. EnalaprilE. Dibazol

51. Magnesium sulphateTests

1. From annotation on magnesium sulfate you know that this preparation is prescribed as aanticonvulsant drug. What rout of administration of injection should be chosen for getting of thispharmacological effect?A intramuscular injectionB sublingualC peroralD rectalE inhalation2. A patient suffers on a cholelithiasis. What preparation is it needed to prescribe for removal ofhepatic colic?

38

A Magnesium sulfate B AmalgelC Contrikal D BisacodylE Pancreatin3. Patient was hospitalized with hypertensive syndrome. What kind of medicine should beprescribed decrease BP?A Magnesium sulfateB DigoxinC NitroglycerineD SpironolactoneE Promedol4. A patient who has chronic cholecystitis was prescribed a cholagogue from cholecystokineticgroup which has laxative, spasmolytic, anthihypertensive, anticonvulsive, sedative effect.a) magnesium sulfateb) pituitrinc) sorbited) atropine sulfatee) papaverine5. Which preparation from group of laxative agents IS NOT to be administered in case ofintoxication with CNS-inhibiting substances?a)* Magnesium sulfateb) Sodium sulfatec) Vaseline oild) Guttalaxe) Bisacodyl

52. PhenofibrateTests

1. For treatment of atherosclerosis a patient has bought hypolipemic preparation of the fibratesgroup. Name this preparation.A PhenofibrateB Drotaverine hydrochlorideC BisacodilD SpironolactoneE Silybor2. To the patient with atherosclerosis an antiatherosclerotic preparation was prescribed.Find this preparation.A Phenofibrate B Ascorbic acidC Pyracetamum D Dexametasone E Butadion3. To treat atherosclerosis a patient bought hypolipidemic drug phenofibrate. What pharmacologicalgroup does this medicine belong to?a) Fibrateb) Nitrofuranc) Calcium channel-blocking agentd) α - adrenoceptor antagoniste) M - cholinergic antagonist4. What medication will you prescribe to treat hyperlipidemia?a) phenofibrat

39

b) pyracetamc) adrenalind) mesatone) cordiamin5. You work at a pharmaceutical firm in the sales department. Explain to interner pharmacist: whatpharmacologycal group does phenofibrate belong to?a) Hypolipidemic drugb) Fibrinolysis inhibitorsc) Soporific drugd) Antihypertensive agentse) Anticoagulant of indirect action6. А patient with atherosclerosis has been administered аn аnti-аthеrоsсlеrоtic agent. Specify this drug:А. Phenofibrate В. PhenylbutazoneС. Ascorbic acidD. DexamethasoneЕ. Pyracetam

53. DoxazosineTests

1. А 70-year-old patient consulted a doctor about elevated arterial pressure. He has a history ofbenign hyperplasia of prostate. What drug should be administered in this case?a). * Doxazosineb). Propranololc). Analapril d). Losartane). Diltiazem

54. FamotidinTests

1. A patient who concerning ulcerous illness a doctor appointed famotidin appealed chemist's.Explain, what mechanism is underlain in action of this preparation? A Blockade of H2-histamins receptorsB Blockade of H1-histamins receptorsC Blockade of M-cholinoreceptorsD Oppression of activity of N+K+ATP-aseE Blockade of cholinoreceptors of likable neuroganglions2. A pharmacist advised a patient antiulcerous preparation which blocks the histamine receptors ofstomach mucous membrane. Name this drug.A FamotidinB Omeprazol C AlmagelD Atropine sulfate E Pirenzepin3. For treatment of peptic ulcer Famotidine was prescribed. Find the mechanism of action ofpreparation. A Blockade of H-2- histamine receptors B Blockade of H-2-histamine receptors C Stimulation of α- adrenoreceptors D Blockade of β- adrenoreceptors E Stimulation of M-cholinoreceptors4. А patient suffering from ulcer disease was prescribed famotidine. What is the mechanism of its

40

action?А. Block of H2-histamine receptorsB. Block of cholinoreceptors of sympathetic ganglionsC. Block of muscarinic cholinoreceptors D. Inblbition of adenosine triphosphatase activityЕ. Block of H1-histaminе reсерtors

55. RanitidineTests

1. A patient suffering from peptic ulcer was administered ranitidine. Gastric juice acidity hasreduced considerably. What mechanism underlies the action of this drug?a). * H2 –histamine receptors blockade b). M-cholinergic receptors blockadec). H1 –histamine receptors blockade d).H,K-ATPase activity inhibitione). Autonomic ganglion H-cholinergic receptors blockade

56. OmeprazoleTests

1. A patient suffering from stomach ulcer was prescribed an antiulcer drug that also reducessecretion of hydrochloric acid and inhibits Chelicobacter pylori. What drug is it?a). *Omeprazole b). Almagelc). Maaloxd). Famotidinee). Gastrocepine2. A patient with gastric ulcer has been administered omeprazole. What is its mechanism of action?A. Inhibition of H+,K+-ATPaseB. Blockade of histamine H2-receptors C. *HCl neutralizationD. Blockade of M-cholinergic receptorsE. Stimulation of mucus production

57. Bismuth subcitrateTests

1. A patient who has been undergoing combined drug therapy for peptic ulcer presents with blackfeces. Specify a drug that might have caused such change:a). * Bismuth subcitrate b). Metronidazolec). Actovegind). Ranitidinee). Omeprazole

58. AlmagelTests

1. A 54-year-old patient who has been suffering from hyperacidic gastritis for several years wasprescribed almagel. What pharmacotherapeutical complications on the part of digestive organs maybe expected in the first place?a). * Constipationb). Emesisc). Nausead).Diarrhea

41

e). Anorexia

2. A patient suffering from stomach ulcer was prescribed almagel. Which of its pharmacologicalproperties is intended for treatment of this pathology? A HCl neutralization B Local anaesthetization C Blocking the H2-histamine receptors D Blocking the muscarinic cholinoreceptors E Anti-inflammatory action

59. BisacodylTests

1. A doctor prescribed bisacodyl to a patient with a chronic constipation. In 3 weeks of treatment apatient paid a regard to diminishing purgative effect. With what side effect is it related? A Adaptation (tolerance)B PredilectionC SensitizingD CumulationE Dysbacteriosis2. A patient bought at a drugstore a medicine to treat a habitual constipation. This agent reflextorystimulates intestinal peristalsis. Find this medicine.a) bisacodylb) calcium chloridec) cyanocobalamind) heparine) furosemide3. An elderly man who has chronic obstipation was prescribed laxative agent which has an effectupon large intestline.a) bisacodylb) alloholc) smectad) maaloxe) cholenzim4. An elderly patient has constipation caused by hipotonia of colon. What drug should beadministered to the patient?A. Novocaine amideB. BisacodylC. Atropine sulfate D. Sodium sulfateE. Castor oil

60. PancreatinumTests

1. A patient has chronic pancreatitis with apparent presentations of pancreatic exocrinehypofunction. Which of the following drugs would be the most appropriate in this case? a). * Pancreatinumb). Drotaverinec). Omeprazoled).Acidin pepsinume). De-Nol

42

61. Ursodeoxycholic acidTests

1. A patient with cholelithiasis was prescribed the following drug for the purpose of cholesterolgallstone dissolution:a). * Ursodeoxycholic acidb). Citric acidc). Gamma-amino-butyric acidd).Acetylsalicylic acide). Mefenamic acid2. A patient with cholelithiasis should be administered the following drug fot th dissolution ofcholesterol gallstones:A. Acetylsaliculic acidB. Citric acidC. Mafanamic acidD. *Ursodeoxycholic acidE. Gamma-aminobutyric acid

62. HydrochlorthiazideTests

1. At drugstore a patient of 60 also bought for course of medicine treatment with otherantihypertensive drugs hydrochlorthiazide to treat hypertension. What mechanism ofantihypertensive action has this drug?a) Reduction of volume of blood circulation, reduction of sensibility of vessels adrenoreceptorsto catecholamines;b) Excitation of central adrenoreceptors, relaxation of vascularmotor center;c) suppression of pereferic α1 – adreboreceptors, reduction of peripheral resistance of vessels;d) suppression of cardiac α1 – adrenoreceptors, reduction of cardiac output;e) suppression of angiotensin converting enzyme, reduction of aldosterone secretion

63. FurosemideTests

1. Name a substitution for furosemide:a) lasixb) hydrochlorothiazidec) spironolactoned) acetazolamidee) clopamide2. A patient with hypertensive crisis should be administered a diuretic as a part of complex therapy. What drug should be given to the patient?

A FurosemideB DiacarbC SpironolactoneD TriamtereneE Amiloride3. It is necessary to conduct artificial diuresis to a patient with the acute poisoning. Whatpreparation can be applied?A FurosemideB Caffeine-sodium benzoate C Galantamine hydrobromideD Enalapril E Pyracetam4. To the patient with an acute poisoning for the forced diuresis loop diuretic was prescribed. What

43

preparation is it.A FurosemideB Mannit C HydrochlorthiazideD TriamterenE Spironolactone5. A patient of 50 years old during 20 yeas has hypertension that is accompanied by edema anddiminishing of diuresis. What preparation must be prescribed to a patient in such a case?A FurosemideB ReserpineC Enalapril D PrazozinE Methyldopa6. You are a pharmacist in a drugstore. Choose a loop diuretic of urgent, powerful, short - livedeffect.a) Furosemideb) Clopamidec) Acetazolamided) Spironolactonee) Triamteren7. A patient which took furosemide for a long time was observed to have reduction of swells,increase of diuresis. However, weakness in muscles, appetite loss, cardial pains. How can thedevelopment of above mentioned symptoms be explained?a) hypokaliemiab) hypermagnesemiac) hypocalcemiad) hypercalcemiae) hyperkaliemia8. A patient has a cardiopulmonary decompensation which is also attended with pulmonary edema.What medicine from diuretic group should one prescribe?a) furosemideb) spironolactonec) dichlothiazided) triamterine) acetazolamide9. Select а loop diuretic of strong, emergency and short-term action frоm the 1isted below:А. TriamterenеВ. SpironolactoneС. AcetazolamideD. FurosemideE. Clopamide10. A patient with hypertensive crisis should be administered a diuretic as a part of complex therapy.What drug should be given to the patient?A FurosemideB DiacarbC SpironolactoneD TriamtereneE Amiloride11. The patient with acute poisoning needs forced diuresis. What drug can be used for this purpose?A. FurosemideB. Caffeine and sodium benzoateC. Galantamine hydrobromide

44

D. EnalaprilE. Piracetam

64. TriamtereneTests

1. Treatment course of essential hypertension includes diuretics. Which diuretic DOES NOT NEEDto be combined with potassium preparations?a)* Triamterenb) Clopamidec) Dichlothiazided) Furosemidee) Ethacrynic acid

65. OxytocinTests

1. Pregnant woman with the weakness of childbirth a doctor decided to stimulate births. Whathormonal preparation was used by a doctor?A OxytocinumB GlibenclamidumC PrednizolonD ThyroxinE Insulin2. As a result of the childbirth weakness a doctor prescribed to a pregnant woman hormonalpreparation for labor induction. Name this preparation. A OxytocinB GlybenclamideC PrednisoloneD InsulinE Thyroxin3. Woman necols labour induction. From the list below, choose the remedy which stimulates uterinecontraction.a) Oxytocinb) Proserinc) Picharpind) Progesteronee) Propranolol4. During uterine inertia one prescribes:a) oxytocinb) no – spac) progesteroned) vicasole) phenotherol5. A female has prolonged labour. Select a drug that stimulates labour activity due to its physilogicaleffect from the listed below:A. PachycarpineB. OxytocinC. ProgesteroneD. EstroneE. Neostigmine

66. CyanocobalamineTests

45

1. A patient which has had a stomach disease for a long time is also detected to have hyperchromicanemia. Which medication listed is used to treat this pathology?a) cyanocobalaminb) ascorbic acidc) unithiold) ferum leke) oxyferriscorbon2. A patient who has been suffering from gastric diseases for long time is found to havehyperchromic anemia. Which of the following drugs is applied for this pathology treatment? a). * Cyanocobalamineb). Ascorbic acidc). Unitiold).Oxyferriscorbonee). Ferrum Lek

67. VicasolTests

1. Advise a doctor the antagonist remedy to stop bleeding caused by long term application ofneodicumarine.a) Vicasolb) Aminocapronic acidc) Ethamsilatd) Fibrinogene) Ascorbic acid2. It was prescribed hemostatic to a child with a diathesis. Name this preparation?A ViсasolB HeparinC NeodikumarinD CyanocobalaminE Magnesium sulfate3. А 45-year-old patient has bееn taking neodicumarinum for thrombophlebitis for two weeks. Тhe regular blood test revealed а decrease in prothrombin conrentration, microhematuria. Which drog should bе used as neodicumarinum antagonist?А. VicasolВ. Aminocaproic acid С. HeparinD. Protamine sulfate Е. Sodium citrate4. Which drug with antagonistic effect can be used to stop bleeding caused by prolonged use ofneodicumarinum?A Viсasol B Aminocapronic acid C Etamsylate D Fibrinogen E Ascorbic acid

68. HeparinTests

1. For treatment of thrombosis a doctor prescribed of direct acting anticoagulants. Name thispreparation. A HeparinB Phenilin

46

C Syncumar D NeodikumarinE Vikasol2. You are the pharmacist of regional clinic hospital. Consult interner doctor who works indepartment of vascular surgery about peculiarity of heparin pharmacokinetics after intravenousinjection.a) effect comes in 5 minutes and lasts 4 – 6 hoursb) effect comes in 30 minutes and lasts 8 – 12 hoursc) becomes effective in 24 – 48 hours, cumulate in bodyd) effect comes in 12 – 30 hours and lasts 3 – 4 days e) effect comes in 30 minutes and lasts to 24 hours3. A patient who has cardiac infarction was injected a direct anticoagulant intravenously. Name thismedicine.a) heparinb) neodicoumarinc) vicasol d) thrombine) calcium gluconate4. For thrombosis treatment a patient was prescribed a drug from the group of direct anticoagulants.What drug is it? a). *Heparinb). Neodicumarinc). Vikasold).Syncumare). Fenilin (phenylinum)5. Which of the following drugs is used for thrombolytic therapy in case of myocardial infarction?A. PhenylinumB. HeparinC. TiclopidineD. StreptokinaseE. Acetylsalicylic acid6. A patient with myocardial infraction has been given an intravenous injection of a direct-actinganticoagulant. Select it among the listed drugs:A. Calcium gluconateB. NeodicumarinumC. ThrombinD. HeparinE. Vikasolum7. Which drug is used for thrombolysis in case of acute myocardial infarction?A. AlteplaseB. Acetylsalicylic acid C. PentoxifyllineD. FraxiparineE. Heparin

69. StreptokinasaTests

1. Which of the below-listed drugs is used for thrombolytic therapy in case of myocardialinfarction? А. РhеnуlinumB. Acetylsalicylic acid С. Heparine

47

D. StreptokinaseE. Тiclopidine

70. FibrinogenTests

1. Which drug with antagonistic effect can be used to stop bleeding caused by prolonged use ofneocumarinum?A. Ascorbic acidB. Aminocapronic acidC. FibrinogenD. VikasolumE. Etamsylate

71. RetinolTests

1. As a result of uncontrolled used of vitamin preparation for treatment a nyctalopia a child had ananorexia, nausea, vomiting, diarrhea, hyperthermia. What preparation was used by a child?A RetinolB Nicotinamid C SomatotropinD RutinE Ergocalciferol2. Pregnant woman used big doses of retinol during 1st trimester of pregnancy and gothypervitaminosis. This drug may induce abnormalities of fetus. Name this side effect.A Teratogenic actionB CumulationC DysbacteriosisD AddictionE Cancerogenic action3. You are pharmacist at chemist’s shop. Choose from medicines delivered to your chemist’s shopthat belongs to medicines liposoluble vitamins containing add.a) acetate retinolb) oxytocinc) acyclovird) heparine) benadryl4. A patient who has a day blidness deterioration (hemeralopy) was prescribed vitamin medicine byan ophthalmologist for holiatry of this pathology.a) retinol acetateb) ascorbic acidc) pyridoxined) nicotinic acidd) ergocalciferol5. A patient consulted an ophthalmologist about scotopic vision impairment, cornea dryness. Whatdrug was prescribed?a)* Retinolumb) Pirydoxinec) Tocopherold) Ascorbic acid e) Cocarboxylasum

72. L-thyroxin48

Tests1. To treat hypofunction of thyroid gland (myxedema) a doctor prescribed a hormonal agent ofthyroid gland. Name this agent.a) L-thyroxin b) insulinc) prednisoloned) glibenclamide) vicasol

73. PrednisoloneTests

1. Patient with an allergodermia asked a doctor. What preparation is it necessary to prescribe asantiinflammatory and antiallergic action?A Prednisolone B AethamidumC OxytocinD InsulinE Thyroxin2. To a patient with rheumatism doctor prescribed preparation that has such side effects:development of „steroid diabetes", edema, osteoporosis, steroid ulcer. Name this preparation.A PrednisoloneB DichlotiazideC MesatoneD ButadionE Strophantin3. Patient with renal insufficiency, has been prescribed medicine for substitutability therapy. Namethis medicine.A PrednisoloneB GlibenclamideC RetabolilD Sodium Diclofenac E L- thyroxin4. A patient was given an intravenous injection of prednisolone solution to relieve severe attack ofbronchial asthma. To which group of hormonal agents does prednisolone belong?a) Glucocorticoidsb) Gestagenic drugsc) Estrogenic drugsd) Mineralocorticoidse) Anabolic steroids5. A patient intook prednisolon for a long time. After the medicine was canceled acute condition ofdisease, blood pressure reduction, inertia appeared. Why do these symptoms occur?a) Adrenal insufficiency appearingb) medication sensitizationc) drug addictiond) ACTH hyperproduction e) drug cumulation6. A 48-year-old patient was given an intravenous injection of prednisolone in order to arrest asevere attack of bronchial asthma. Prednisolone relates to the following group of hormonal drugs: a). *Glucocorticoidsb). Estrogensc) Gestagenic drug d) Anabolic steroids

49

e) Mineral corticoids7. A 33-year-old woman who has been treated for chronic polyarthritis for a long time complaniesabout arterial pressure rise, change of adipose tissue distribution, menstrual cycle disorder. Whatpreparation has she taken?a). * Prednisoloneb). Synaflanc). Butadiond). Diclofenac sodiume). Indometacin8. A patient with atopic dermatitis presented at the hospital. Which drug with anti-inflammatory andanti-llergic effect should be administered to this patient?A. PrednisoloneB. OxytocinC. AethamidumD. RetabolilE. Insulin

74. InsulinTests

1. A patient who has pancreatic diabetes was prescribed insulin. What injection regimen does hasthis medicine have.a) 20 minutes before food intakeb) before going to sleepc) 40 minutes after meald) when eatinge) 1,5 hours before food intake2. A 15-years old patient has been first diagnosed with type I diabetes mellitus. Whichantihyperglycemic drug should be administered in this case?A. DiabetoneB. MetforminC. GlibenclamideD. GlurenormE. Insulin

75. GlibenclamideTests

1. Insulin dependent patient with diabetes mellitus was also prescribed synthetic antidiabeticmedicine. Name this medicine.A GlibenclamideB InsulinC CholosasD PrednisoloneE Hydrochlorthyazide2. A patient has pancreatic diabetes of 1 type (insulin – dependent). To reduce daily draught hisendocrinologist has prescribed an artificial hypoglycemic agent. Name it.a) Glibenclamidb) Hydrochlorothiazidec) Lipamidumd) Glucagone) Hydrocortisone3. To the patient with insulin-dependent diabetes mellitus synthetic antidiabetic preparation from thegroup of sulfanylurea derivates was prescribed. Name this preparation.

50

A Glybenclamid B Insulin C Anaprilin D Prednisolone E Furosemide

76. DexametazoneTests

1. Examination of a patient who has been treated for rheumatoid arthritis for a long time revealedhyperglycemia. It might have been caused by the following drugs: a)* Dexamethasoneb) Delagilc) Diclofenac sodiumd) Ibuprofen e) Levamisole2. Examination of a patient who has been treated for rheumatoid arthritis for long time revealedhyperglycemia. What drug might have caused it?a)* Dexamethasoneb) Chloroquinec) Levamisole d) Ibuprofen e) Diclofenac sodium

77. Calcium chlorideTests

1. After an intravenous injection of magnesium sulfate respiratory impairment began, arterialpressure decreased. What antidote should one inject?a) Calcium chlorideb) Potassium chloridec) Camphord) CaffeineUnithiol

78. DimedrolTests

1. Selling dimedrol to patient for him to relieve contact dermatitis about what typical drug sideeffect should you warn him?a) Dry mouth, sleepinessb) Short cough, closenessc) Disposition to sweating; improvement to appetited) Stimylation of CNS, palpitatione) Arterial pressure decrease

79. LoratadineTests

1. A pharmacist was asked by patient who had neurodermatitis to recommend an antihistaminicdrug of 2 generation without inhibitory action on CNS. What is this drug?a) Loratadineb) Dimedrolc) Diazolind) Tavegile) Phenkarol

51

2. A student asked a pharmacist to advise him a medication to suppress signs of allergic rhinitiswhich appear during time blossom. What medication could be used?a) loratadineb) adrenaline, epinephrinec) propranolold) ambroxole) lozartan3. A patient who is a driver addresses a doctor. He has rhinitis, hacking, lacrimation which hasappeared during ambrosia blossom. What antiallergenic drug should be prescribed?a) loratadineb) benadrylc) prednisoloned) calcium chloridee) amoxicilin4. A patient with a contact allergic dermatitis after bee stings was prescribed loratadine. Itching andpainfulness disappeared. What mechanism of antiallergic action has this medicine?a) suppression of H1 – histamine receptors;b) suppression of H2 – histamine receptors;c) blockade of D4 – leukotriene receptors;d) reduction of leukotriene release;e) antiserotonin activity5. Recommend for a patient a drug for allergy treatment. A Loratadin B NaphthyzinC Levamisole D Glybenclamide E Ascorutin6. A man came to a pharmacy and asked to recommend him a drug for treatment of allergic rhinitisthat occurs in the period when lime tree is in bloom. What drug may be applied?a)* Loratadineb) Adrenalinec) Anaprilined) Ambroxole) Lozartan7. Consult a patient on which antihistamine drug DOES NOT have sedative and hypnotic effect:A LoradatineB DiphenhydramineC PromethazineD SuprastinumE Tavegil (Clemastine)

80. Kalii permanganasTests

1. What anti-infective agent could show his bactericidal action by creating atomic oxygen.A Kalii permanganasB ChloraminC FuracyllinD AethoniumE Argentii nitras2. A bedridden patient suffers bedsores, festers. What antiseptic from oxidizing agents group withdeodorant effect should one use to debride wound?a) Permanganate potassium

52

b) hydrogen peroxidec) brilliant greend) ioddicerinee) phenol solution3. Which antiseptic preparation has bactericidal effect due to the formation of atomic oxygen?a)* Potassium permanganate b) Silver nitratec) Furacilinumd) Aethoniume) Chloraminum

81. NifuroxazidTests

1. An internship doctor prescribed his patient nifuroxazid from the group of nictofurans fortreatment of urinary tracts infection. The doctor made a mistake because:a)* It can not be absorbed from the digestive tractb) It has bacteriostatic effectc) It is excreted from the organism very slowlyd) It has nephrotoxic effecte) It is excreted with urine in the inactive state2. Аn internship doctor prescribed his patient nifuroxazid from the groиp of nitrofurаns for thetreatment of urinary tracts infection. Тhe doctor made а mistake because:А. It has bacteriostatic effectB. It has nephrotoxic effectС. It cannot bе absorbed from the digestive tractD. It is excreted from the organism very slowlyE. It is excreted with urine in the inactive state

82. Alcoholic iodine solution Tests

1. Choose an antiseptic from the group of halogen containing drugs that can be included into thefirst-aid kit for a child going to a summer camp: A Alcoholic iodine solution B Brilliant green solution C Copper sulfate solution D Methylene blue solution E Formaldehyde solution

83. BenzylpenicillinTests

1. To treat bacterial pneumonia benzylpenicillin was prescribed. What mechanism of antimicrobicaction has this medicine?a) suppression of microorganism cell wall synthesisb) suppression of intracellular synthesis of proteinc) abnormality of cytoplasmic membrane penetrationd) suppression of SH–groups microorganism enzymese) antagonism with paraaminobenzoic acid 2. Select antibiotic for syphilis treatment: a) benzylpenicillinb) streptomycinc) kanamycin d) amphotericyn

53

e) nystatin3. Why benzylpenicillin sodium is not used orally?a) it is inactivated by HCl in stomachb) is badly absorbed in bowelsc) irritates stomach mucous membraned) reduce production of HCl in bowelse) is ruined by penicillinaza4. You work in a drugstore which is located on the territory of the dermatovenerologic dispensary.Consult the interner doctor, what antibiotic is the drug for the syphilis treatment.a) Benzylpenicillin sodium saltb) Lincomycin hydrochloridec) Levorinum sodium saltd) Streptomycin sulfatee) Polymyxin M sulfate5. What mechanism of action deferment bactericidal effects of benzylpenicillin?A Stoppage of synthesis of microorganisms cell wallB Oppressing of synthesis of albuminsC Damages of permeability of citoplazmatic membraneD Activating of the immune system of macroorganismE Increases of phagocytic activity of leucocytes6. Benzylpenicillin sodium is not used per os, because this drug:a). *Destroys gastric HClb). Poorly absorbed in the intestinec). Reduces formation of gastric HCld). Irritates gastric mucosae). Is destroyed by penicillinase7. А gravida in her 20th week of gestation got ill with pneumonia. What chemotherapeutical drugmау bе administered with nо risk for the fetus development?A. BenzylpenicillinumB. GentamycinС. SulfalenumD. LaevomycetinumE. Ofioxacinum8. Benzathine benzylpenicillin is the drug of choice for treating the following disease:A. FurunculosisB. Intestinal infectionsC. SyphilisD. PneumoniaE. Angina

84. AmoxicillinTests

1. A man with a long history of chronic hepatitis has been diagnosed with pneumonia. Which of the foolowing antibacterial drugs can be applied in this clinical situation?A. BiseptolB. RifampicinC. AmoxicillinD. TetracyclineE. Vancomycin2. A female patient in the first trimester of pregnancy has been diagnosed with acute pyelonephritis. What is the antibiotic drug of choice for treating this patient?A. Norfloxacin

54

B. GentamicineC. AmoxicillinD. AmikacinE. Chloramphenicol

85. Doxycycline hydrochlorideTests

1. Name the medicine from tetracycline group which was prescribed to treat acute bronchitis.a) doxycycline hydrochlorideb) benzylpenicillinc) acyclovird) isoniazide) chingamin2. In a city N. when analyzing of drinking water a cholera bacillus was detected. What medicineshould one prescribe to patients in case of cholera symptoms?a) doxycyclineb) erythromycinc) bicylin – 5 d) benzylpenicillin sodiume) benzylpenicillin potassium3. To the patient doxycycline hydrochloride was prescribed in pills. Explainto the patient, how correctly should he use this preparation?A To swallow a whole pill, washing down waterB To chew a pill, accepting during a mealC To use to the meal, washing down milkD To accept together with an antacidE To hold in an oral cavity to resolution4. To a patient for treatment pneumonia doxycycline hydrochloride was prescribed. What group ofantibiotics does this preparation belong to?A Tetracyclins B AminoglykosidesC Macrolides D Cephalosporins E Penicillins5. During treatment of bronchitis a patient had dyspepsia disorders,photodermatosis, disorders of liver function. What preparation induced these phenomena?A DoxycyclineB ParacetamolC Ascorbinic acidD AcetylcysteinE Codeine phosphate6. In course of pharmacotherapy of bronchitis a patient was found to have dyspeptic disorders,photodermatitis, liver dysfunction. Which of prescribed drugs might have caused thesemanifestations?a). * Doxycyclinb). Acetylcysteinumc). Ascorbic acidd).Codeine phosphatee). Paracetamolum7. In course of pharmacotherapy of bronchitis a patient was found to have dyspeptic disorders,photodermatitis, and liver dysfunction. Which of the prescribed drugs might have caused thesemanifestations?

55

A. Codeine phosphateB. AcetylcysteinumC. *DoxycyclinD. Ascorbic acidE. Paracetamolum

86. TetracyclineTests

1. A doctor at a recreation center when suspecting cholera subscribed to a patient doxycyclinehydrochloride. To what group of antibiotic does this medicine belong?a) tetracyclineb) penicillinc) cephalosporind) cyclic polypeptidese) macrolides2. Absorption of tetracycline preparations will be reduced when they are administeredsimultaneously with antacids. This is an example for: A Pharmacokinetic incompatibility B Pharmaceutical incompatibility C Pharmacodynamic incompatibility D Drugs synergism E Functional drugs antagonism

87. CefotaximeTests

1. A pregnant woman fell ill with severe pneumonia. What antibacterial drug may be prescribed?a). * Cefotaximeb). Co-trimoxazolumc). Gentamycin sulfated). Ofloxacinume). Tetracycline hydrochloride

88. CeftriaxonTests

1. A patient fell ill with severe pneumonia was prescribed ceftriaxonum once a day. Prescription ofceftriaxonum once a day connected with the fact that drug :a). *Slowly eliminated from the body b). Has bactericidal effectc). Accumulates in the lungsd). Pluripotentiale). Poorly absorbed from the injection site

89. PhthalazolTests

1. A patient being treated in infection disease ward for dysentery is administered phthalazol. What isthe reason for phthalazol being used only for treatment of enteric infections?a). The drug is not absorbed from the gastrointestinal tractb). The high degree of reabsorption in the kydneyc). Rapidly excreted in unchanged formd).Slowly eliminated from the bodye). Rapidly absorbed in the gastrointestinal tract

90. Co-trimaxozoleTests

56

1. Which of the listed antibacterial drugs should NOT be administered to a patient with diabetesmellitus type II being treated with glibenclamid?a). * Co-trimoxazolumb). Doxycyclinec). Benzylpenicillinumd). Midecamycine). Gentamycinum2. A pharmacy has sulfonamide biseptol on sale. What chemical compounds are the maincomponents of this drug?a). * Sulfamethoxazole, trimetoprimb). Phthalazolum, sulfadimezinc). Sulgin, norsulfazold). Urosulfan, sulfapiridazine). Sulfazin,salazodimethoxinum3. Which of the listed antibacterial drugs should NOT bе administered to а patient with diabetes mellitus type II being treated with glibenclamid?А. Co-trimoxazolum В. Benzylpenici1linum С. Doxycycline D. GentamycinumE. Мidecamycin

91. IsoniazidTests

1. Studying about the antituberculosis drugs do not forget about the most effective artificial drugwhich is used different localization of tubercular process.a) Isoniazidb) Ethambutolc) Streptomycind) Thiocetasone) Lomefloxacin2. A patient has consumption. While anticonsumption treatment, eye - neuritis has appeared. Choosethe medicine which has provoked this complication.a) isoniazidb) rimphampicinc) kanamycind) ethambutole) sodium para-aminosalicylate3. To treat pulmonary tuberculosis a patient was prescribed antitubercilosis medicine, inactivationspeed of it by means of acetylation in liver is genetically conditioned and differs in differentindividuals. Define this medicine.a) isoniazidb) azitromicinc) amoxicilind)amicacine) cyprofloxacin4. A 67-year-old patient was diagnosed with disseminated pulmonary tuberculosis. What drug willprovide etiotropic pharmacotherapy?a). * Isoniazidb). Lincomicinc). Thrimethoprimd). Metronidazole

57

e). Benzylpenicillin sodium salt

92. RifampicineTests

1. Patient with pulmonary form of tuberculosis was prescribed as an combined therapyantituberculous antibiotic. Name this medicine.A RifampicineB BenzylpenicyllinC DoxycyclineD CephtriaxonE Azytromicyn2. Patient has tuberculosis. What preparation is used to treatment this disease?A RifampicinB TetracyclinC GentamycinD AmpicillinE Levomycetin3. A 32-year-old patient takes antituberculous drugs. Some time later he has noticed that his urineturned orange. What preparation is the most likely cause of this phenomenon?a)* Rifampicinb) Streptomycin sulfatec) Ethambutold) Pyrazinamidee) Isoniazid

93. RovamycineTests

1. Choose a optimal antibacterial drug for the mycoplasmal pneumonia treatment:a). * Rovamycineb). Amoksiklavc). Penicillind).Gentamycinume). AmpicillinА 26-year-old patient was diagnosed with community-acquired pneumonia provoked bymycoplasma. Choose the appropriate antimicrobial preparation for the patient treatment:a). * Rovamycineb). Amoksiklavc). Benzylpenicillinumd).Gentamycinume). Amoxicillin

94. StreptomycineTests

1. A woman who has been treated for infiltrative local tuberculosis for a long time complains ofacute hearing impairment. Which of the following preparations might be the cause of such sideeffect?a)* Streptomycinb) Isoniazidc) Etambutold)Ethionamidee) Rifampicin

58

95. AcyclovirTests

1. A patient has herpetic appearance of skin rash. What medicine should one prescribe?a) acyclovirb) gentamycinc) clotrimazold) benzylpenicilline) biseptol2. A patient after supercooling has herpes infection on lips. What preparation can be recommendedto a patient?A AcyclovirB ItraconazolC AmoxycillinD PrednisoloneE Azidotimidine3. A patient infected with herpes is prescribed a viricide. Choose it. a) acyclovirb) gancyclovirc) zidovudined) remantadine) lamivudin4. Help a young doctor to choose chemotherapeutic agent available at your chemist’s shop fortreatment herpes.a) Acyclovirb) Rimphampicinc) Doxycycline hydrochlorided) Chingamine) Zidovudine5. What chemotherapeutic agent is a drug of choice for treatment of herpes?A. AcyclovirB. RifampicinC. Doxycycline hydrochlorideD. ChingaminE. Metronidazole

96. ChingaminTests

1. For individual prevention of malaria a medicine was prescribed. Find ita) chingaminb) riphampicync) ampicillind) gentamycine) biseptol

97. MetronidazoleTests

1. A pharmacist told to a patient about the effects and mechanism of metrodinazole action. Find theelements mechanism of this drug action:A Blocking of of alcohol dehydrogenase enzyme

59

B Activating of alcohol dehydrogenase enzymeC Blocking of acetylcholinesterase enzymeD Activating of acetilkholinesterase enzymeE Activating of glucose -6- phosphodehydrogenase enzyme2. Which of anti - protozaal remedy is used in combination to medical triatment gastric ulcer?a) Metronidazoleb) Famatidinc) Omeprasold) Sucralfate) Allumag3. To treat trichomoniasis one should use:a) metronidazoleb) oletetrinc) norphloxacind) nystatine) klaphoran4. To treatment gastric ulcer, a doctor to recommend an antihelicobacther drug. What is this drug?a) metronidazoleb) omeprazalonc) phamotidind) gastrocepine) phestal5. Trichomoniasis is identified. What antimicrobial medicine should one prescribe?a) metronidazoleb) ampicillinc) kanamycind) amphotericyne) nystatin6. A doctor-interner asked, what preparation it is better to prescribe to a patient with a diagnosis:amoeb dysentery.A MetronidazolB PyrantelC Levomizole D BicillinE Benzilpenicillin7. A 56-year-old patient was diagnosed with systemic amebiasis accompanied by bowels, liver andlungs affection. What preparation should be administered?a)*Metronidazoleb) Chiniofonc) Tetracyclined) Chingamine) Phthalazol8. A consulting pharmacist informed a patient about possible side effect of metronidazole that isnormally provoked by alcohol intake. What is the mechanism of this phenomenon?a). * Enzyme alcohol dehydrogenase blockingb). Enzyme glucose 6-phosphaterase blockingc). Enzyme acethylcholinesterasa blockingd). Enzyme acethylcholinesterasa activatione). Enzyme alcohol dehydrogenase activation9. А 52-year-old patient was diagnosed with systemic amebiasis accompanied by bowels, liver and lungs affection. What preparation should bе administered?А. *Metronidazole

60

В. PhthalazolС. ChingaminD. ChiniofonЕ. Tetracycline10. What drug is more advisable for the patient with amebic dysentery?A. *MetronidazoleB. PyrantelC. LevamisoleD. Bicillin-5E. Benzylpenicillin sodium salt (Penicillin G sodium salt)

98. PyracetamTests

1. After a craniocerebral trauma a patient was administered pyracetam. This drug related to thefollowing pharmacological group:a). * nootropic agentb). tranquilizersc). nonnarcotic (nonopioid) analgeticd). anesthetic agente). neuroleptic

99. DeferoxamineTests

1. Which preparation is the specific antidote in case of intoxication with iron preparation?a). * Deferoxaminb). Penicillaminc). Atropinumd).Bemegridume). Protamine sulfate

100. UnitiolumTests

1. Which of the listed preparations should be used as antidote and included into the first-aid kitrequired at factories where acute intoxications with arsenic, mercury, chrome and bismuthcompounds are possible?a)* Unithiolumb) Adrenalinumc) Droperidolumd) Morphinume) Atropinum2. During the treatment of chronic heart failure with digoxin in a patient having bradycardia, nausea, vomiting, blurred vision. Which drug is the antidote in this case?A. Atropine sulphateB. Tetacinum calciumC. DipiroximumD. Amyl nitriteE. Unithiol3. During digitoxin therapy for chronic cardiac insufficiency, a patient developed signs ofintoxication with this preparation. The patient was prescribed unithiol. What is the mechanism ofunithiol action in case of intoxication with cardiac glycosides?A Reduction of К+-Na+-adenosine triphosphatase B Binding of calcium ions

61

C Increase of sodium concentration in the cardiomyocytes D Increased potassium permeability in the cardiomyocytes E Binding of glycoside into the complex compound4. Treatment of poisonings with inorganic compounds includes the use of the following antidote:A. UnithiolB. DexamethasoneC. DesferalD. Tetacinum-calciumE. Naloxone

101. LosartanTests

1. A patient with hypertension has been prescribed a drug that blocks angiotensin receptors. Specify this drug:A LosartanB NifedipineC PrazosinD CaptoprilE Apressin

102. ClonidineTests

1. A patient with hypertensive crisis has been given an intravenous injection of clonidine. Whatmechanism underlies the antihypertensive effect of clonidine?A Stimulation of presynaptic central α2 adrenoceptorsB Blockade of peripheral α1-adrenoceptorsC Blockade of beta-adrenoceptorsD Blockade of N-cholinergic receptorsE Direct myotropic effect on blood vessels

62