STUDY PROGRAM 2021/2022 Subjects of the 5-6. semesters ...

UP FP Pharmacy major – Obligatory subjects in the 5-6. rec. semester - Course descriptions – academic year of 2021/2022

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University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2021/2022

Subjects of the 5-6. semesters

(obligatory subjects and criterion requirements)


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Table of Contents

5th semester

OPG-BFR-T Biopharmacy ________________________________________________________________________________ 3

OPG-C1E-T Pharmaceutical Technology 1 - Theory ____________________________________________________________ 5

OPG-C1G-T Pharmaceutical Technology 1 - Practice____________________________________________________________ 8

OPG-O1E-T Pharmacognosy 1 - Theory _____________________________________________________________________ 11

OPG-O1G-T Pharmacognosy 1 - Practice ____________________________________________________________________ 15

OPG-R1E-T Pharmaceutical Chemistry 1 - Theory ____________________________________________________________ 17

OPG-R1G-T Pharmaceutical Chemistry 1 - Practice ____________________________________________________________ 19

OPO-GE2-T Pharmaceutical Biochemistry 2 _________________________________________________________________ 22

OPO-IMM-T Basic Immunology ___________________________________________________________________________ 25

OPO-MI1-T Microbiology 1 ______________________________________________________________________________ 27

6th semester

OPG-C2E-T Pharmaceutical Technology 2 - Theory ___________________________________________________________ 29

OPG-C2G-T Pharmaceutical Technology 2 - Practice___________________________________________________________ 31

OPG-O2E-T Pharmacognosy 2 - Theory _____________________________________________________________________ 33

OPG-O2G-T Pharmacognosy 2 - Practice ____________________________________________________________________ 38

OPG-R2E-T Pharmaceutical Chemistry 2 - Theory ____________________________________________________________ 40

OPG-R2G-T Pharmaceutical Chemistry 2 - Practice ____________________________________________________________ 42

OPO-I2E-T Microbiology 2 - Theory ______________________________________________________________________ 44

OPO-I2G-T Microbiology 2 - Practice ______________________________________________________________________ 46

OPO-KTN-T Pathophysiology _____________________________________________________________________________ 48

OPR-SG2-T Professional Practice 2 ________________________________________________________________________ 53


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OPG-BFR-T BIOPHARMACY

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

2 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 1 – 80 Prerequisites: see your Recommended Curriculum

Topic

Aim of this course is to introduce biopharmaceutical aspects of medicines taking into account dosage forms and routes of administration.

Basic pharmacokinetic aspects (kinetics of active agents, compartmental analysis, routes of administration), some in vitro and in silico

biopharmaceutical practices (using special biopharmaceutical softwares) are presented, bioequivalence studies of medicines are

discussed. Students learn to design and develop pharmaceutical dosage forms according to biopharmaceutical requirements. Single and

repeated dosing calculations are discussed according to pharmaceutical and physiological aspects.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Students have to write three assessments during the semester and they have to reach 60,1 % after average calculation. After two

assessments if students reach average 60,1 % taking into account both tests, writing the third assesment it not compulsory. The third

assessments (which is considered as the 1st retake) has to above 60,1 %. If the student fails on the 3rd assessment, there is still chance

for the 2nd retake, where student has to reach 60,1% for the acceptance of the semester. In case of confirmed absence from the assessment,

re-take chance is possible for the student. Missing the re-take results 0 % assessment.

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Leon Shargel, A. B.C: .Applied Biopharmaceutics and Pharmacokinetics, Yu, Stamford

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

www.gytk.pte.hu

www.sciencedirect.com

Lectures

1 Subject and general approach of biopharmacy

Dr. Pál Szilárd

2 Subject and general approach of biopharmacy

Dr. Pál Szilárd

3 Drug delivery systems and the input options

Dr. Pál Szilárd

4 Drug delivery systems and the input options

Dr. Pál Szilárd

5 Biopharmaceutical classification of substances and pharmaceutical preparations

Dr. Pál Szilárd

6 Biopharmaceutical classification of substances and pharmaceutical preparations

Dr. Pál Szilárd

7 Biopharmaceutical basics of drug qualification I (drug liberation studies)

Dr. Pál Szilárd

8 Biopharmaceutical basics of drug qualification I (drug liberation studies)

Dr. Pál Szilárd

9 Biopharmaceutical basics of drug qualification II (dissolution and absorption models)

Dr. Pál Szilárd

10 Written test

Dr. Pál Szilárd

http://www.sciencedirect.com/


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11 Biopharmaceutical basics of drug qualification II. (IVIVC, original and generic preparations)

Dr. Pál Szilárd

12 Biopharmaceutical basics of drug qualification II. (IVIVC, original and generic preparations)

Dr. Pál Szilárd

13 LADME system and its control options I

Dr. Pál Szilárd

14 LADME system and its control options I

Dr. Pál Szilárd

15 LADME system and its control options II

Dr. Pál Szilárd

16 LADME system and its control options II

Dr. Pál Szilárd

17 Written test

Dr. Pál Szilárd

18 Written test

Dr. Pál Szilárd

19 Biopharmaceutical basics of medicinal therapy I (dermal and transdermal therapy)

Dr. Kása Péter

20 Biopharmaceutical basics of medicinal therapy I (dermal and transdermal therapy)

Dr. Kása Péter

21 Biopharmaceutical basics of medicinal therapy II (eye, nasal and ear preparations)

Dr. Pál Szilárd

22 Biopharmaceutical basics of medicinal therapy II (eye, nasal and ear preparations)

Dr. Pál Szilárd

23 Biopharmaceutical basics of medicinal therapy III (hormonal disorders)

Dr. Pál Szilárd

24 Biopharmaceutical basics of medicinal therapy III (hormonal disorders)

Dr. Pál Szilárd

25 Biopharmaceutical basics of medicinal therapy IV (chronotherapy, cardiovascular diseases, asthma)

Dr. Pál Szilárd

26 Biopharmaceutical basics of medicinal therapy IV (chronotherapy, cardiovascular diseases, asthma)

Dr. Pál Szilárd

27 Biopharmaceutical basics of medicinal therapy V (specific medicinal therapy)

Dr. Kása Péter

28 Written test

Dr. Pál Szilárd

Practices

Seminars

Exam topics/questions

Students will receive the topic lists in the Institute and/or on the website.

At the end of semesters, students take oral exam.Exams is preceded by the "Minimum Test" (MT). To write the MT, students have at

most 30 minutes, and will be evaluated by percentage. Those students, who achieve less than 60% in MT, will get unsatisfactory

grade and cannot continue with the oral part of the exam.

In addition to the exam topics, part of the exam is answering questions that aim at assessing the general knowledge of the student.

Participants

Dr. Dévay Attila (BSX334), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)


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OPG-C1E-T PHARMACEUTICAL TECHNOLOGY 1 - THEORY






Topic

Courses of pharmaceutical technology are taught in the 3rd and 4th years of school of pharmacy. Aim of courses of Pharmaceutical

Technology is introducing basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into

account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients.

Further studies include review of national and international pharmacopoeias.

Practices usually begin with seminars where basic introduction of the proper lesson takes place. After seminars students have to prepare

medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculation of single and

daily maximal dose, preparation, labeling and pricing. Students also have to prepare galenic formulations according to the official

formula. Practices of quality control of medicines are carried out as well.

Course Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solution, syrup, elixir, oral drop, ear drop, nasal

drop, parenteral solution and associated calculations with practices of quality control of mentioned dosage forms.


Code of Studies and Regulations

Mid-term exams

Students have to write three assessments during the semester and they have to reach 60 % after average calculation. After two assessments

if students reach average 60 % taking into account both tests, writing the third assesment it not compulsory. The third assessments (which

is considered as the 1st retake) has to above 60,1 %. If the student fails on the 3rd assessment, there is still chance for the 2nd retake,

where student has to reach 60,1% for the acceptance of the semester. In case of confirmed absence from the assessment, re-take chance

is sossible for the student. Missing the re-take results 0 % assessment.



Reading material



- Notes


European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London


Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

www.gytk.pte.hu


Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

1 Defination of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical

technology, basic terms.

Dr. Pál Szilárd

2 Defination of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical

technology, basic terms.

Dr. Pál Szilárd

3 Dispensing and compounding at a pharmacy (measurement, treatment of substances)

Dr. Pál Szilárd

4 Dispensing and compounding at a pharmacy (measurement, treatment of substances)

Dr. Pál Szilárd

5 Basics of technological operations, biopharmaceutical aspects

Dr. Pál Szilárd

http://www.gytk.pte.hu/



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6 Basics of technological operations, biopharmaceutical aspects

Dr. Pál Szilárd

7 Technological importance of substances

Dr. Pál Szilárd

8 Technological importance of substances

Dr. Pál Szilárd

9 Dissolution

Dr. Secenji Aleksandar

10 Written test

Dr. Pál Szilárd

11 Excipients used to increase of API’s solubility

Dr. Pál Szilárd

12 Excipients used to increase of API’s solubility

Dr. Pál Szilárd

13 Mixing and stirring

Ámanné Dr. Takácsi-Nagy Anna

14 Mixing and stirring

Ámanné Dr. Takácsi-Nagy Anna

15 Heat transferes


16 Heat transferes


17 Interaction and incompatibility of pharmaceutical preparations

Dr. Pál Szilárd

18 Interaction and incompatibility of pharmaceutical preparations

Dr. Pál Szilárd

19 Written test

Dr. Pál Szilárd

20 Written test

Dr. Pál Szilárd

21 Sterilization, depyrogenation, aseptic working, eye preparations

Dr. Pál Szilárd

22 Sterilization, depyrogenation, aseptic working, eye preparations

Dr. Pál Szilárd

23 Preparation and examination of injection (API, excipients, solvents, containers, examination)

Dr. Pál Szilárd

24 Preparation and examination of injection (API, excipients, solvents, containers, examination)

Dr. Pál Szilárd

25 Infusions and implants. The most important class of injectable and plantable preparations

Dr. Pál Szilárd

26 Infusions and implants. The most important class of injectable and plantable preparations

Dr. Pál Szilárd

27 Written test

Dr. Pál Szilárd

28 Written test

Dr. Pál Szilárd

Practices

Seminars


The criterion of admission to the exam is the successful completion of the Pharm. Tech . 1. practice.

The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list

of topics provided by the institute.The end-semester exam will be evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

At the end of semester, students take oral exam. Chance "B"and "C" are also oral exams, which is preceded by the "Minimum Test"(MT).

To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less than 60%

in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to

unsatisfactory grade.


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Participants


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OPG-C1G-T PHARMACEUTICAL TECHNOLOGY 1 - PRACTICE



5 credit ▪ midsemester grade ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5



Topic

Courses of pharmaceutical technology are taught in the 3rd and 4th years of school of pharmacy. Aim of courses of Pharmaceutical

Technology is introducing basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into

account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients.

Further studies include review of national and international pharmacopoeias.

Practices usually begin with seminars where basic introduction of the proper lesson takes place. After seminars students have to prepare

medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculation of single and

daily maximal dose, preparation, labeling and pricing. Students also have to prepare galenic formulations according to the official

formula. Practices of quality control of medicines are carried out as well.

Course Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solution, syrup, elixir, oral drop, ear drop, nasal

drop, parenteral solution and associated calculations with practices of quality control of mentioned dosage forms.


1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin

expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Evaluation of the practices is according to the semester work (practice work, assessments, work reports) by practice grade. In case of

fulfilled 1-3 sections, the requirement of the accepted semester is to reach at least satisfactory grade.

Mid-term exams

Students have to participate two practice tests.



All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Reading material



- Notes







www.gytk.pte.hu




Lectures

Practices

1 General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions








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6 Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations





11 Complex solutions, mixtures, drops





16 Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops





21 Preparation and examination of pure solutions, alcoholic solutions





26 Preparation and examination of syrups and colloid solutions





31 Preparation and examination of mucilages and colloid solutions





36 Assessment

37 Assessment

38 Assessment

39 Assessment

40 Assessment

41 Sterilizing, isotonisation, calculations, eye drops





46 Preparation of eye drops, ointments





51 Preparation and examination of injections





56 Preparation and examination of infusions





61 Preparation and examination of emulsions and suspensions





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66 End semester assessment





Seminars


Website of the Institute.

Participants

Ámanné Dr. Takácsi-Nagy Anna (SEGAOR), Dr. Kása Péter (ISWPRM), Dr. Lendvai Botond István (U0UI6H), Dr. Pál Szilárd

(FYF5E9)


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OPG-O1E-T PHARMACOGNOSY 1 - THEORY

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy [email protected]




Topic

Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene

technology, critical evaluation of holistic medicine and homeopathy, possibilities of phytotherapy) and discusses the chemical

composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and

drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with

medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are

required to recognize the most important tea drugs and drugs with strong physiological effect that are traded and/or imported in Hungary.

In the frame of practices students obtain experience in drug analysis and identification methods and the ability to solve daily arising

problems, with special emphasis on processing information from literature, databases and the internet.

Course objective and role in the curriculum: students should become familiar with plant materials and drugs, as well as their effective

substances in general.



Mid-term exams

Students need to write 1 written exam based on the lectures (acceptance: min. 60%). In the case of failed exam, there is one possibility

to rewrite it. In the case of failed practice result, there is no possibility to try the oral exam. At oral exam: 2 topics. Final results of oral

exam: oral communication + lecture written exam + practice result

If somebody writes the 4 drug reports with min. fullfill 90% (4 x 90%)during the semester, will receive rid of the drug entrance exam in

Pharmacognosy 2. oral exam.


There is no possibility to make up for the missed lectures.

Reading material



1. Farkas Á., Horváth Gy., Molnár P.: Pharmacognosy 1, digital learning material, 2014 TÁMOP-4.1.2.A/1-11/1-2011-0016

2. Farkas Á., Papp N., Bencsik T., Horváth Gy.: Digital Herbarium and Drug Atlas, digital learning material, 2014 TÁMOP-

4.1.2.A/1-11/1-2011-0016

Course materials will be sent by Neptun for students.

- Notes


1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London-New York, 2000

2. Aronson J.K. (ed.): Meyler?s Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009

3. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition, Pharmaceutical Press, London-Chicago, 2002

4. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition, Thieme, Exeter, Stuttgart, New York, 2003

5. Poole C.F., Poole S.K.: Chromatography Today, Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991

6. WHO Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants, 2003

7. Kayser O., Quax W. (eds.): Medicinal Plant Biotechnology, volume 1-2, Wiley, Weinheim, 2007.

Lectures

1 Introduction of the requirements of the course. Scope and subject of Pharmacognosy.

Dr. Horváth Györgyi

2 Natural substances in pharmaceutical research. (Traditional) herbal medicines and dietary supplements.


3 Wild, protected and cultivated medicinal plants.

Dr. Ács Kamilla

4 Tea drugs, primary processing of medicinal plants, plant extracts. Qualification and phytochemical evaluation of medicinal plants.

Dr. Ács Kamilla


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5 Carbohydrates.


6 Drugs containing carbohydrates.


7 Biosynthesis and classification of terpenoid.

Dr. Deli József

8 Drugs containing monoterpenes.


9 Triterpenes.

Dr. Ács Kamilla

10 Drugs containing triterpenes, steroids, saponins.

Dr. Ács Kamilla

11 Phytotherapy.


12 Aromatherapy.


13 Iridoids.


14 Drugs containing iridoids.


15 Other therapies based on medicinal plants.


16 Drugs of animal and fungus origin.


17 Written test.


18 Medicinal plant biotecnology.


19 Synthesis, role and usage of lipids. Oils and waxes.


20 Drugs containing vegetable oils and waxes.


21 Cianogenic glycosides and glycosinolates.


22 Drugs containing cianogenic glycosides and glycosinolates.


23 Essential oils.


24 Essential oils.


25 Sesquiterpenes, diterpenes and phloroglucinols.


26 Drugs containing sesquiterpenes, diterpenes and phloroglucinols.


27 Special amino acid derivatives. Cardenolides and bufadienolides.


28 Drugs containing special amino acid derivatives. Cardenolides and bufadienolides.


Practices

Seminars


The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the

result different from ?failed?).

1. Definition of Pharmacognosy. Herbariums.

2. Ethno-pharmacobotany.

3. Natural substances in pharmaceutical research.


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4. Hierarchy of herbal products traded Hungary: Herbal medicine, Traditional herbal medicinal product, Herbal tea, Dietary supplement.

5. Wild and protected medicinal plants, collection of medicinal plants.

6. Plant biotechnology and gene technology.

7. Tea drugs, primary processing, extracts.

8. Industrial medicinal plants.

9. Qualification and phytochemical evaluation of medicinal plants, requirements of the pharmacopoeia.

10. Phytotherapy.

11. Aromatherapy.

12. Homeopathy.

13. Drugs of fungus and animal origin: Secale cornutum, Tinder fungus, Laricis fungus, Reishi, Shii-take, Schizophyllum commune,

Lichen islandicus, Lichen quercus, Blatta orientalis, Cantharis, Cetylis palmitas, Gelatin, Hirudo medicinalis, Jecoris aselli oleum,

Mel.

14. Significance of photosynthesis, structure and chemical composition of the chloroplast. Light reactions of photosynthesis.

15. The nitrogen cycle, nitrogen fixation.

16. Nitrogen assimilation and sulphate reduction. Nitrogen- and sulphur-containing compounds in the pharmaceutical practice.

17. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic acid;

C4 and CAM type plants.

18. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins, mannans,

gummi arabicum, heteropolysaccharides: occurrence, medicinal usage.

19. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-?-phosphatidic acid, cholamine, choline, serine,

inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine,

sphingo- and glycolipids.

20. Fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants.

21. Structure of arachidonic acid, ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Physical and

chemical parameters of fats and oils, occurrence in plants, medicinal usage.

22. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and utilisation

of waxes.

23. Prostaglandins: discovery, occurrence; chemical structure; biosynthetic precursor; biological effects, medicinal usage.

Polyacetylenes: synthesis, features, occurrence in plants, biological role.

24. Isoprenoid compounds I. Isoprene rule; modes of linking of isoprene units; natural and artificial polyisoprenes.

25. Isoprenoid compounds II. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA), isopentenyl

pyrophosphate (IPP)]; main steps of biosynthesis.

26. Isoprenoid compounds III. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few examples;

occurrence, biological role, medicinal usage.

27. Isoprenoid compounds IV. Iridoids, pyrethroids, sesquiterpenes: chemical structure of the cyclopenta-pyranoid skeleton; occurrence

in plants, biological role, application in medicine.

28. Isoprenoid compounds V. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene.

Occurrence, biological role and medicinal usage of triterpenoid saponins.

29. Proteinogenic amino acids I.: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine,

glutamic acid, glutamine, histidine, leucine, isoleucine.

30. Proteinogenic amino acids II: Structural formula and chemical name of lysine, methionine, phenylalanine, proline, hydroxyproline,

serine, threonine, tryptophan, tyrosine, valine.

31. Important amino acid reactions I. a.) Basic reaction of transamination; b.) reductive desamination ? formation of ?-amino acids from

?-keto acids ?-oxo acids); c.) formation of glutamine from glutamic acid.

32. Important amino acid reactions II: a.) Decarboxylation; b.) oxidative desamination; c.) formation of asparagine from aspartic acid.

33. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic acid and

carbamide. Allantoin, as the most well-known plant ureid.

34. Specific amino acids: chemical structure of ?-amino-butyric acid (GABA), ?-amino-butyric acid (BABA) and ?-alanine; formation,

significance in plants; chemical transformation.

35. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA).

Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide.

Occurrence of propenyl-cysteine.

36. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification

according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromelain, ficin).

37. The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence,

biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

38. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in

their biosynthesis (ornitin, lysine, phenylalanine, tyrosine, tryptophan, histidine).

39. Alkaloids II. Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine,

piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure).

40. Alkaloids III. Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological

features, application.


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41. Alkaloids IV. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine

and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline).

42. Alkaloids V. Tropane alkaloids ? Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortropane, tropane,

tropine (3?-hydroxi-tropane) and tropic acid. Atropine, hyosciamine, scopolamine ? structure, occurrence, biological effect,

application in medicine and elsewhere.

43. Alkaloids VI. Structure of pseudotropine (3 ?-hydroxi-tropane), ecgonine and cocaine; occurrence and biological effects of cocaine.

Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect.

44. Alkaloids VII. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine.

45. Alkaloids VIII. Opium alkaloids: a.) Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid.

46. Alkaloids IX. Opium alkaloids: b.) Structure of morphine; biological effect, medical usage. Biological effects and medical application

of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin].

47. Alkaloids X. LSD as the most important derivative of lysergic acid. Biological effects and medical application of important ergot

alkaloids.

48. Alkaloids XI. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and caffeine;

occurrence, biological effects, usage.

49. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of ?-phenyl-propionic acid, trans (E)-

cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic

acid and quinic acid).

50. Phenoloids II. The hydroquinone ? para-benzoquinone transformation. Quinone derivatives and their significance in plant

biochemistry. Phenol-carboxylic acids of benzoic acid origin, e.g. gallic acid: structure, occurrence in plants, significance in biology

and medicine.

51. Phenoloids III. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic

acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy.

52. Phenoloids IV. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivative: para-coumaryl alcohol.

Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

53. Phenoloids V. Coumarins. Chemical structure of coumarin and coumaric acid. Aesculin, dicoumarol and furanocoumarins;

occurrence in plants; biological and medicinal significance.

54. Phenoloids VI. Flavonoids: Structure of ?- and ?-pyran, ?- and ?-pyrone and coumarin (?-pyrone condensed with benzol). Structure

of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and

isolation of rutin (vitamin P).

55. Phenoloids VIII. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl ?-

D-glucose. Occurrence, features and application of tannins.

56. Phenoloids IX. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological

effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and

anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective

substances of hop and their structure.

Participants


15

OPG-O1G-T PHARMACOGNOSY 1 - PRACTICE






Topic








problems, with special emphasis on processing information from literature, databases and the internet.

Course objective and role in the curriculum: students should become familiar with plant materials and drugs, as well as their effective

substances in general. During the practices, macroscopic and microscopic examinations of the drugs are organized.


Practices are compulsory.

Mid-term exams

In the case of failed practice result, there is no possibility to try the oral exam. Students need to take one practice oral presentation during

semester. Final result of the practice will be included in the result of oral exam. Preparation of practice notebook is compulsory. There

are 4 small written exams (drug identification practice) during semester.


There is possibility to make up for the missed practices but with the course supervisor’s permission.

Reading material



- Notes

Bencsik T, Ács K, Farkas Á, Molnár P, Papp N, Horváth Gy (2015): Pharmacobotanical and phytochemical investigation of herbal

drugs - Teaching supplement. University of Pécs


Lectures

Practices

1 Introduction. Methods of analysis for medicinal plants in the European Pharmacopoeia. Investigation of Matricariae flos on the

basis of the Ph.Eur. Drugs with carbohydrate content I. Microscopic distinction of starch grains.





4 Drugs with carbohydrate content II. Identification of unknown drugs based on pharmacopoeial descriptions.



7 Drugs with essential oil I. Organoleptic examination of essential oils. Identification of Lamiaceae-type glandular trichomes and

essential oil cavities.





10 Drug identification test 1. Drugs with essential oil II. Identification of unknown drugs based on pharmacopoeial descriptions.

Identification of Asteraceae-type glandular trichomes.




16



13 Drugs containing triterpene saponins. Distinction of Solidaginis herba and Solidaginis virgaureae herba based on

micromorphological features.





16 Problem-based learning on medicinal plants.



19 Drug identification test 2. Drugs containing bitter substances I. Determination of the bitterness value by organoleptic evaluation.



22 General methods of analysis for drugs of plant origin. Accident and fire-protection instruction. Nitrate, nitrite detection in

drinking water and nettle tea.





25 Written test. Analysis of drugs containing carbohydrates; honey adulteration test.



28 Written test. Analysis of fatty oils.



31 Separation and identification of carotenoids.



34 Written test. Analysis of drugs containing essential oil. Essential oil extraction for quantitative measurements, detection of

essential oil components.





37 Written test. TLC examination of drugs containing bitter substances. Chemical reactions of cardiac glycosides.



40 Extraction and detection of alliin.



Seminars


Not relevant.

Participants

Dr. Ács Kamilla (EWOCN2), Dr. Horváth Adrienn (IUT27D)


17

OPG-R1E-T PHARMACEUTICAL CHEMISTRY 1 - THEORY

Course director: DR. ATTILA ALMÁSI, assistant professor

Department of Pharmaceutical Chemistry [email protected]




Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Introduction to the pharmacokinetics and

pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical

ingredients with central nervous system activity.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the

practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Two compulsory midterm tests (on

the topics of the lectures and practices) will be written during the semester on the 7th and the 12th weeks. Both of the test result should

be above 60%. Students can have one retake per midterm test. Students have to write at least four mini-tests on the practices. The average

of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical

grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Mid-term exams

If the student did not take part writing the midterm test, she or he can participate the retake, only. There is no chance for extra possibilities.


There is no opportunity to make up missed classes.

Reading material


D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins,

Philadelphia, 2013


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry I. Laboratory Experiments and Commentary, electronic

educational material, PTE 2014

Zsuzsanna Rozmer, Pál Perjési: Physico-Chemical Bases of Drug Action. Electronic educational material, PTE 2015

- Notes

Pharmaceutical Chemistry Practice I., Laboratory manual, University of Pécs, 2015


European Pharmacopoeia, EDQM Publication

Lecture notes.

Lectures

1 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of

substances.

Dr. Perjési Pál

2 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of

substances.

Dr. Perjési Pál

3 Physical and physicochemical methods of the European Pharmacopoeia.

Dr. Kulcsár Győző Kornél

4 Identification and qualitative tests of the European Pharmacopoeia.

Dr. Kulcsár Győző Kornél

5 Protein-specific test methods of the European Pharmacopoeia.

Dr. Perjési Pál

6 Protein-specific test methods of the European Pharmacopoeia.

Dr. Perjési Pál

7 The fate of xenobiotics in the body. The receptor theory.

Dr. Perjési Pál


18

8 The fate of xenobiotics in the body. The receptor theory.

Dr. Perjési Pál

9 Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions.

Dr. Perjési Pál

10 Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions.

Dr. Perjési Pál

11 Structural and physical chemical basis of drug action. Structure-activity relationships.

Dr. Perjési Pál

12 Structural and physical chemical basis of drug action. Structure-activity relationships.

Dr. Perjési Pál

13 Transport processes. Transporters and ion channels as drug targets.

Dr. Rozmer Zsuzsanna

14 Transport processes. Transporters and ion channels as drug targets.


15 Central and peripheral receptors. Receptors as drug targets.


16 Central and peripheral receptors. Receptors as drug targets.


17 Structure and functions of enzymes. Enzymes as drug targets.


18 Structure and functions of enzymes. Enzymes as drug targets.


19 Phase 1 metabolic transformations.

Dr. Almási Attila


Dr. Almási Attila


Dr. Almási Attila


Dr. Almási Attila

23 Drug metabolism and drug toxicity.

Dr. Perjési Pál

24 Drug metabolism and drug toxicity.

Dr. Perjési Pál

25 General anesthetics.


26 General anesthetics.


27 Narcotic analgesics.

Dr. Almási Attila

28 Narcotic analgesics.

Dr. Almási Attila

Practices

Seminars


Written exam covering the topics of the lectures and the laboratory practices. The result of the first part of the written exam (Minimum

Written Test) should be at least 80%. In the case of the third („C”) exam the written exam is evaluated regardless the result of the

Minimum Written Test. The list of the possible questions of the Minimum Written Test is announced on the Neptun system. The

result of the written exam must be above 60%. The final grade is based on results of the midterm tests and the written exam. Maximum

contribution of the results of the midterm tests to the total score of the written exam is 25%. Participation on the first exam is

compulsory.

Participants


19

OPG-R1G-T PHARMACEUTICAL CHEMISTRY 1 - PRACTICE






Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Pharmacopoeal analysis of selected inorganic

substances.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory.

Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must

be at least 50%. Quantitative measurements should be carried out with the acceptance level of 70%! The practical work (results of the

written tests and the experimental work) is evaluated by a practice grade.

Mid-term exams

The short practical test can be made up on the next practical.


There is no opportunity to make up missed practices.

Reading material




educational material, PTE 2014.

- Notes

Pharmaceutical Chemistry Practice I., Laboratory manual, University of Pécs, 2015.


Lectures

Practices

1 Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests

of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.







5 Calculation of results. Experimental errors. Acidum hydrochloridum dilutum, Natrii chloridum, Chloraminum.




9 Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii

chloridum.


chloridum.


chloridum.


chloridum.

13 Inorganic pharmacopoeial substances II. Oxygen group.. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii

hydroxidum.


hydroxidum.


20


hydroxidum.


hydroxidum.

17 Inorganic pharmacopoeial substances III. Sulphur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad

usum externum.


usum externum.


usum externum.


usum externum.

21 Inorganic pharmacopoeial substances IV. Nitrogen compounds. Ammonii chloridum, Natrii nitris, Kalii nitras, Bismuthi

subnitras.


subnitras.


subnitras.


subnitras.

25 Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii

dihydrogenophosphas, Dinatrii phosphas







29 Inorganic pharmacopoeial substances VI. Carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii

hydrogencarbonas.


hydrogencarbonas.


hydrogencarbonas.


hydrogencarbonas.

33 Inorganic pharmacopoeial substances VII. Pharmaceutical excipients (Seminars).




37 Inorganic pharmacopoeial substances VIII. Alkaline earth metals. Earth metals. Silicon compounds. Magnesii sulfas, Magnesii

subcarbonas, Magnesii oxydum, Magnesii trisilicas, Silica, colloidal hydrated, Acidum boricum, Borax.







41 Inorganic pharmacopoeial substances IX. Metals. Aluminii oxidum hydricum, Aluminii sulfas, Zinci oxydum, Zinci chloridum,

Ferrosi sulfas, Kalii permanganas.







45 Physico-chemical parameters influencing the biological effect (solubility, pKa, logP). Determination of logP.




49 Classification of functional groups and heterocycles (seminar).




21


53 Basics of stereochemistry. Stereochemistry of morphine and derivatives.




Seminars


Questions of the above short tests are from the topics of the practical and seminary.

Participants

Dr. Almási Attila (KJ5MBZ)


22

OPO-GE2-T PHARMACEUTICAL BIOCHEMISTRY 2

Course director: DR. KATALIN SIPOS, associate professor

Department of Pharmaceutical Biology [email protected]

4 credit ▪ final exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5



Topic

The two-semester biochemistry course provides the essential fundamental biochemistry knowledge for the pharmaceutical students. This

course deals with the metabolic pathways of the living cell: the reactions, steps and regulation of these pathways. In the second semester

besides to learn the pathways of amino acid and nucleptid metabolism, students will synthetize their biochemical knowledge of the main

metabolic pathways, as well as the biochemistry of organs. We will pay special attention to the steps of biotransformations, which play

important role in the metabolism of drugs. In the second half of the semester students will study the most important chapters of

pathobiochemistry.



Mid-term exams

There is no written mid-term exam in the semester.


According to personal agreement

Reading material



The materials of the lectures and seminars will appear on Neptune.

- Notes

The e-notes of Biochemistry will be uploaded to Neptune.


Ch. P. Woodbury: Biochemistry for the Pharmaceutical Sciences

Raymond S. Ochs: Biochemistry

Thomas M. Devlin: Textbook of Biochemistry with Clinical Correlations

Lectures

1 Absorption and synthesis of amino acids I.

Dr. Farkas Viktória

2 Absorption and synthesis of amino acids II.


3 Break down of amino acids.


4 Importance of ammonia. Urea cycle.

Dr. Sipos Katalin

5 Clinical applications of amino acid metabolism

Pap Ramóna

6 Purine biosynthesis


7 Pyrimidine biosynthesis


8 Degradation of nucleotides. Gout I.


9 Degradation of nucleotides. Gout II.


10 Biochemistry of iron metabolism I.

Dr. Pandur Edina

11 Biochemistry of iron metabolism II.

Dr. Pandur Edina


23

12 Biochemistry of vitamins.

Jánosa Gergely

13 Microsomal mono-oxygenase system. Cytochrome P450 I.

Dr. Sipos Katalin

14 Microsomal mono-oxygenase system. Cytochrome P450 II.

Dr. Sipos Katalin

15 Metabolic integration: caloric intake.

Pap Ramóna

16 Metabolic integration: the functions of the liver I.


17 Metabolic integration: the functions of the liver II.


18 Metabolic integration: tissues of brain, muscle, heart. Sport activity. Pregnancy.


19 Macronutrients: carbohydrates.

Dr. Sipos Katalin

20 Macronutrients: proteins.

Jánosa Gergely

21 Macronutrients: lipids.

Dr. Sipos Katalin

22 Metabolism of alcohol.

Pap Ramóna

23 Diabetes mellitus I.


24 Diabetes mellitus II.


25 Genes and biochemistry I.

Pap Ramóna

26 Genes and biochemistry II.

Pap Ramóna

27 Pathobiochemistry of hemoglobin.

Dr. Pandur Edina

28 Biochemistry of hormones: amino acid derivatives, peptides.

Dr. Sipos Katalin

29 Biochemistry of hormones: proteins

Dr. Sipos Katalin

30 Biochemistry of hormones: steroids.

Dr. Pandur Edina

31 Digestion and transport of proteins.

Pap Ramóna

32 Digestion and fate of carbohydrates.


33 Digestion and fate of lipids.

Dr. Sipos Katalin

34 Drug development.

Dr. Sipos Katalin

35 Drug development.

Dr. Sipos Katalin

36 Neurotransmitters.

Pap Ramóna

37 Regulation of carbohydrate metabolism I.


38 Regulation of carbohydrate metabolism II.


39 Regulation of lipid metabolism.

Dr. Sipos Katalin

40 Regulation of amino acid and nucleotide metabolisms.

Jánosa Gergely


24

41 Drugs inhibiting enzymes.

Dr. Pandur Edina

42 Preparation for exam

Dr. Sipos Katalin

Practices

1 Enzyme activity measurement: LDH.

2 Enzyme activity determination: ALP.

3 Basic prinsiples of enzymatic analyses.

4 Determination of blood glucose concentration with enzymatic analysis.

5 Clinical laboratory methods I.

6 Clinical laboratory methods II.

7 Biochemical methods of protein analyses.

Seminars

1 Photosynthesis I.

2 Photosynthesis II.

3 Principles of enzyme activity measurements.

4 Biochemical laboratory methods: enzymes.

5 Biochemical laboratory methods: proteins.

6 Biochemical methods of drug discovery.

7 Biochemical methods of drug development.


There are no given exam questions. The topics of the exam will be the materials of lectures and seminars.

Participants

Dr. Farkas Viktória (G9AV8T), Dr. Pandur Edina (ZP0077), Dr. Sipos Katalin (RUHPLE), Jánosa Gergely (U3SEOW), Pap Ramóna

(OGEM0W)


25

OPO-IMM-T BASIC IMMUNOLOGY

Course director: DR. KRISZTIÁN KVELL, associate professor

Department of Pharmaceutical Biotechnology [email protected]

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5



Topic

Introduction to the current immunology. Organisation of the human immune system: organs, tissues, cellular and molecular components.

Regulation of immune functions: recognition, differentiation, effector functions, memory formation, suppression of the immune response,

immunological tolerance. Main aspects of immune response. Basics of immune related diseases and their pharmacological therapies

including allergy, autoimmune diseases, organ transplantation, immunity against tumours. The course is discussed from a pharmacist

prespective.



Mid-term exams

Immunology quizlets. Writtem test at mid-term.


Not possible.

Reading material



- Notes


A.K. Abbas, A.H. Lichtman and A. Pillai: Cellular and Molecular Immunology, 6th edition, Elsevier

Janis Kuby: Immunology

Jan Klein: Immunology

Lectures

1 Introduction to immunology, its history, main tasks. Components of the immune system, its cells, organs and tissues.

Dr. Kvell Krisztián

2 Molecular elements of immune recognition: MHC molecules, antibodies, (B-cell receptor) and T-cell receptors.


3 The complement system as innate humoral immunity. Antigen presentation on the surface of MHCI and II molecules.


4 Antigen structure, its immune recognition. Immunological gene rearrangement, lymphocyte maturation, differentiation.


5 B-cell differentiation and maturation in the bone marrow. T-cell maturation and differentiation in the thymus.


6 T-cell activation, its signal transduction, the role of apoptosis. Revision and consultation.


7 Central immune response: T-B cooperation, cellular interactions. Development and control of immunological memory.


8 The course of an immune response. Lymphocyte recirculation and homing. The control and inhibition of immune responses.


9 Active and passive immune tolerance. Local and systemic immune responses.


10 Effector functions and their control: humoral and cellular effector functions.


11 The cytokine network, its role in controling the immune response. Th1-Th2 differentiation. Control of isotype switch.


12 Inherited and acquired immune deficiencies.



26

13 Auto-immunity and tumor immunology. The immunology of transplantation.


14 Antibody-based applications and their production. Hybridoma technology and molecular cloning.


Practices

Seminars

1 Introduction to immunology, its history, main tasks. Components of the immune system, its cells, organs and tissues.


2 Molecular elements of immune recognition: MHC molecules, antibodies, (B-cell receptor) and T-cell receptors.


3 The complement system as innate humoral immunity. Antigen presentation on the surface of MHCI and II molecules.


4 Antigen structure, its immune recognition. Immunological gene rearrangement, lymphocyte maturation, differentiation.


5 B-cell differentiation and maturation in the bone marrow. T-cell maturation and differentiation in the thymus.


6 Written test.


7 Central immune response: T-B cooperation, cellular interactions. Development and control of immunological memory.


8 The course of an immune response. Lymphocyte recirculation and homing. The control and inhibition of immune responses.


9 Active and passive immune tolerance. Local and systemic immune responses.


10 Effector functions and their control: humoral and cellular effector functions.


11 The cytokine network, its role in controling the immune response. Th1-Th2 differentiation. Control of isotype switch.


12 Inherited and acquired immune deficiencies.


13 Auto-immunity and tumor immunology. The immunology of transplantation.


14 Antibody-based applications and their production. Hybridoma technology and molecular cloning.



Multiple choice questions prepared according to the subject of the lectures. The written exam test might contain minimum requirement

questions where the wrong answers could mean failure on the exam.

Participants

Dr. Kvell Krisztián (Y0GLOV)


27

OPO-MI1-T MICROBIOLOGY 1

Course director: DR. MÓNIKA BÁTAI-KERÉNYI), associate professor

Department of Medical Microbiology and Immunology [email protected]; [email protected]

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5



Topic

During the course the morphology, physiology of microbes, the techniques of disinfection and sterilization, the basics of antimicrobial

therapy and the drugs used will be discussed. The host-parasite interactions, the factors playing roles in the pathogenesis of infections,

the defense mechanisms of the host and the modes of prevention will be detailed. In this semester some lecture from systematic

bacteriology are given. The objective is to provide a solid microbiological basis that will contribute to understanding detailed

microbiology and further pharmacological studies.


Attendance of the lectures is up to the judgement of the student. The materials of the lectures will be a part of the examinations.

The students will have to successfully complete a written colloquium in the exam period

Mid-term exams


Reading material


Denyer SP, Hodges NA, Gorman SP, Gilmore BF: Hugo and Russells Pharmaceutical Microbiology, 8th Edition, Blackwell Science

Ltd 2018. ISBN: 978-1-119-43449-8

Tim Sandle: Pharmaceutical Microbiology: Essentials for Quality Assurance and Quality Control, ELSEVIER SCIENCE &

TECHNOLOGY,Woodhead Publishing Ltd, 2015 ISBN10 0081000227


Lectures on the Neptun

- Notes


Dr. Patrick R. Murray, Dr. Ken S. Rosenthal and Dr. Michael A. Pfaller (eds.): Medical Microbiology, 8th edition, Elsevier Saunders

2020, ISBN13 (EAN): 9780323673228

F.H. Kayser, K.A. Bienz, J. Eckert, R.M. Zinkernagel: Medical Microbiology, Thieme Stuttgart 2005, ISBN: 3-13-131991-7

Lectures

1 Introduction the subject of microbiology, Taxonomy

Dr. Emődy Levente

2 Morphology and structure of bacteria - essential cell components

Dr. Tigyi Zoltán

3 Morphology and structure of bacteria - accessorial cell components

Dr. Tigyi Zoltán

4 The physiology of bacteria, nutration types and growth of bacteria

Dr. Kocsis Béla

5 Microbial genetics

Dr. Tigyi Zoltán

6 Pathogenicity and virulence

Dr. Emődy Levente

7 Sterilization

Dr. Bátai Istvánné (Dr. Kerényi Mónika)

8 Disinfection


9 Microbiological evaluation of drugs. Pyrogenicity testing

Dr. Kocsis Béla

10 Antimicrobial drugs - general information. Pharmacodynamic and pharmacokinetic effects

Zsoldiné Dr. Urbán Edit


28

11 Inhibitors of bacterial cell wall synthesis I


12 Inhibitors of bacterial cell wall syntheisi II.; Membran targeting drugs


13 Inhibitors of protein synthesis I


14 Inhibitors of protein synthesis II, Chemotherapy: sulfonamids, antimycobacterial drugs, quinolons, mitrofurans


15 Mechanisms of Resistance


16 Immunology of infectious diseases I

Dr. Polgár Beáta

17 Immunology of infectious diseases II

Dr. Polgár Beáta

18 Immunology of infectious diseases III

Dr. Polgár Beáta

19 Immunotherapy I

Dr. Polgár Beáta

20 Immunotherapy II

Dr. Polgár Beáta

21 Vaccinology I

Dr. Emődy Levente

22 Vaccinology II

Dr. Emődy Levente

23 Pyogenic bacteria I


24 Pyogenic bacteria II


25 Pyogenic bacteria III


26 Enteric bacteria and gastrointestinal pathogens I

Dr. Tigyi Zoltán

27 Enteric bacteria and gastrointestinal pathogens II

Dr. Tigyi Zoltán

28 Enteric bacteria and gastrointestinal pathogens III

Dr. Tigyi Zoltán

Practices

Seminars


Written exam consists of multiple choice questions

Participants


29

OPG-C2E-T PHARMACEUTICAL TECHNOLOGY 2 - THEORY



2 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 6



Topic

This semester include practice with ocular dosage forms. Special formulations of ocular dosage forms are eye ointments and oily and

viscous eye drops. Other formulations such as emulsion, suspension and semisolid dosage forms (ointment, cream, gel, paste) are also

discussed.


Students have to write three assessments during the semester and they have to reach 60 % after average calculation. After two assessments

if students reach average 60 % taking into account both tests, writing the third assesment it not compulsory. The third assesments has to

above 60,1 %. In case of confirmed absence from the assessment, re-take chance is sossible for the student. Missing the re-take results 0

% assessment.

Mid-term exams




Reading material



- Notes







www.gytk.pte.hu




Lectures

1 Dispers systems (emulsions, amulgents)

Dr. Kása Péter

2 Dispers systems (emulsions, amulgents)

Dr. Kása Péter

3 Dispers systems (suspension)

Dr. Kása Péter

4 Dispers systems (suspension)

Dr. Kása Péter

5 Importance and determination of particle size

Dr. Kása Péter

6 Importance and determination of particle size

Dr. Kása Péter

7 Filtration, sedimentation, centrifugation

Dr. Pál Szilárd

8 Filtration, sedimentation, centrifugation

Dr. Pál Szilárd

9 Extraction and pressing

Dr. Pál Szilárd




30

10 Extraction and pressing

Dr. Pál Szilárd

11 Written test

Dr. Pál Szilárd

12 Written test

Dr. Pál Szilárd

13 Reologic properties of ointments, Excipients for preparation of ointments

Dr. Pál Szilárd

14 Reologic properties of ointments, Excipients for preparation of ointments

Dr. Pál Szilárd

15 Structural properties of ointments and their preparation

Dr. Pál Szilárd

16 Structural properties of ointments and their preparation

Dr. Pál Szilárd

17 Examinations of ointments

Dr. Pál Szilárd

18 Written test

Dr. Pál Szilárd

19 Excipients of liquid and semi-solid dosage forms

Dr. Pál Szilárd

20 Excipients of liquid and semi-solid dosage forms

Dr. Pál Szilárd

21 Suppositories, pessaries, medicated sticks

Dr. Pál Szilárd

22 Suppositories, pessaries, medicated sticks

Dr. Pál Szilárd

23 Medical aids.

Dr. Pál Szilárd

24 Medical aids.

Dr. Pál Szilárd

25 Technology of medications for veterinary use

Dr. Pál Szilárd

26 Technology of medications for veterinary use

Dr. Pál Szilárd

27 Tools for medical aids and surgical dressing

Dr. Pál Szilárd

28 Written test

Dr. Pál Szilárd

Practices

Seminars


The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list

of topics provided by the institute.The end-semester exam will be evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

At the end of semester, students take written exam. The "A" chance exam is in determined date for students finishing the course. Chance

"B" and "C" are oral exams, which is preceded by the "Minimum Test" (MT). To write the MT, students have at most 30 minutes,

and will be evaluated percent rating. Those students, who achieve less than 60% in MT, unsatisfactory grade will be assessed and

cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to

unsatisfactory grade.


Participants


31

OPG-C2G-T PHARMACEUTICAL TECHNOLOGY 2 - PRACTICE



5 credit ▪ midsemester grade ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 6



Topic

This semester include practice with ocular dosage forms. Special formulations of ocular dosage forms are eye ointments and oily and

viscous eye drops. Other formulations such as emulsion, suspension and semisolid dosage forms (ointment, cream, gel, paste) are also

discussed.


1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin

expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Evaluation of the practices is according to the semester work (practice work, assessments, work reports) by practice grade. In case of

fulfilled 1-3 sections, the requirement of the accepted semester is to reach at least satisfactory grade.

Mid-term exams



All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Reading material



- Notes







www.gytk.pte.hu www.sciencedirect.com



Lectures

Practices

1-70 General instructions, rules and regulations on practices, introduction to emulsions, suspensions and oinments

Preparation and examination of suspensions

Preparation and examination of magistral emulsions and ointments I.

Preparation and examination of magistral emulsions and ointments II.

Magistral ointments/creams/pastes/gels

Preparation and examination of ointments and creams

Preparation and examination of gels and pastes

Assessment

Preparation and examination of suppositories, calibration

Preparation and examination of rectal suppositories

Preparation and examination of vaginal suppositories

Examination of packaging materials

Visiting pharmaceutical company

End semester assessment




32

Seminars


Website of the Institute.

Participants

Ámanné Dr. Takácsi-Nagy Anna (SEGAOR), Dr. Kása Péter (ISWPRM), Dr. Lendvai Botond István (U0UI6H), Dr. Pál Szilárd

(FYF5E9)


33

OPG-O2E-T PHARMACOGNOSY 2 - THEORY



2 credit ▪ final exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 6



Topic








problems, with special emphasis on gathering information from literature, databases and the internet.

Course objective and role in the curriculum: students should become familiar with the general, phytochemical and pharmacological

features of drugs applied in pharmaco- and phythotherapy.



Mid-term exams

One written exam (min. 60%) based on lectures is compulsory. In the case of failed result, there is one possibility to rewrite it. There is

no possibility to take oral exam if somebody receives failed practice result. Oral exam: 2 topics. Before oral exam, there is a drug

identification entrance exam. If somebody failed the entrance exam, student cannot continue the oral exam. Result of oral exam includes:

entrance exam, oral communication, lecture written exam, practice result.

If somebody writes the 4 drug reports with min. fullfill 90% (4 x 90%)during the semester, will receive rid of the drug entrance exam in

Pharmacognosy 2. oral exam.


There is possibility to make up for the missed lectures.

Reading material



1. Györgyi Horváth: Drug reactions in Pharmacognosy, teaching supplement for the pharmacognosy practices, University of Pécs,

Department of Pharmacognosy, Pécs, 2011.

2. Györgyi Horváth, Péter Molnár, Tímea Bencsik: Pharmacognosy 2, digital learning material, 2014.

Course materials will be available on Neptun.

- Notes


1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London-New York, 2000

2. Aronson J.K. (ed.): Meyler?s Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009

3. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition, Pharmaceutical Press, London-Chicago, 2002

4. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition, Thieme, United Kingdom-Stuttgart-

USA, 2003

5. Poole C.F., Poole S.K.: Chromatography Today, Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991

Lectures

1 General characterization of alkaloids and their main groups. Purin-containing drugs


2 General characterization of alkaloids and their main groups. Purin-containing drugs


3 Drugs containing ornithine, lysine and phenylalanine-derived alkaloids


4 Drugs containing ornithine, lysine and phenylalanine-derived alkaloids



34

5 Drugs containing tryptophan and histidine alkaloids


6 Drugs containing tryptophan and histidine alkaloids


7 General characterization of phenoloids and their main groups

Dr. Ács Kamilla

8 General characterization of phenoloids and their main groups

Dr. Ács Kamilla

9 Drugs containing flavonoids


10 Drugs containing flavonoids


11 Drugs containing coumarins. Drugs containing phenylpropanoids and terpenophenols


12 Drugs containing coumarins. Drugs containing phenylpropanoids and terpenophenols


13 Drugs containing anthranoids and naphthoquinone derivatives


14 Drugs containing anthranoids and naphthoquinone derivatives


15 Midterm written exam


16 Midterm written exam


17 Drugs containing polyphenols

Dr. Ács Kamilla

18 Drugs containing polyphenols

Dr. Ács Kamilla

19 Poisonous plants

Dr. Farkas Ágnes

20 Poisonous plants

Dr. Farkas Ágnes

21 Phytochemical and biological screening of herbs (medicinal plants)


22 Phytochemical and biological screening of herbs (medicinal plants)


23 Medicinal plant research in the XXI. century: Plant-origin antiviral compounds


24 Medicinal plant research in the XXI. century: Plant-origin antiviral compounds


25 Medicinal plant research in the XXI. century: Phytoestrogens


26 Medicinal plant research in the XXI. century: Phytoestrogens


27 Medicinal plant research in the XXI. century: Plant-origin antidiabetic compounds


28 Medicinal plant research in the XXI. century: Plant-origin antidiabetic compounds


Practices

Seminars


The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the

result different from ?failed?).

Exam questions:

I. General part. Phytochemistry.


35

1. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic acid; C4

and CAM type plants. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin),

cellulose]. Pectins, mannans, gummi arabicum, heteropolysaccharides: occurrence, medicinal usage.

2. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-?-phosphatidic acid, cholamine, choline, serine,

inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine,

sphingo- and glycolipids. Physical and chemical characteristics of fats and oils. Biosynthesis of fatty acids. Structure of important

saturated and unsaturated fatty acids occurring in plants.

3. Arachidonic acid, prostaglandins: discovery, occurrence, chemical structure, biological effects, medical usage. Structure of ricinoleic

acid, ricinine and ricin; occurrence, biological and medicinal importance. Oils of animal origin: chemical structure of the most

important compounds in cod-liver oil, medicinal usage. Structure and utilisation of waxes. Polyacetylenes: synthesis, features,

occurrence in plants, biological role.

4. Isoprenoid compounds. Isoprene rule; modes of linking of isoprene units; occurrence, biological role, medicinal application; natural

and artificial polyisoprenes. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA), isopentenyl

pyrophosphate (IPP)]; main steps of biosynthesis. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes

with a few examples; occurrence, biological role, medicinal usage.

5. Iridoids, pyrethroids, sesquiterpenes: chemical structure; occurrence in plants, biological role, application in medicine. Diterpenes,

triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene. Occurrence, biological role and

medicinal usage of triterpenoid saponins.

6. Proteinogenic amino acids: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine,

glutamic acid, glutamine, histidine, leucine, isoleucine, lysine, methionine, phenylalanine, proline, hydroxyproline, serine, threonine,

tryptophan, tyrosine, valine.

7. Important amino acid reactions a.) Basic reaction of transamination; b.) reductive desamination → formation of ?-amino acids

from ?-keto acids (?-oxo acids); c.) formation of glutamine from glutamic acid; d.) decarboxylation; e.) oxidative desamination; f.)

formation of asparagine from aspartic acid. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation

of ureids, glycolic acid, glyoxylic acid and carbamide. Allantoin, as the most well-known plant ureid.

8. Specific amino acids: chemical structure of ?-amino-butyric acid (GABA), ?-amino-butyric acid (BABA) and ?-alanine; formation,

significance in plants; chemical transformation. Occurrence and significance of canavanine. Structure, occurrence and biological

effect of L-dihydroxy-phenylalanine (L-DOPA). Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and

occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

9. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification

according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromealin, ficin). The place and main steps

of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence, biological role and application

of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

10. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in

their biosynthesis (ornithine, lysine, phenylalanine, tyrosine, tryptophan, histidine). Structure of N-containing heterocyclic

compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine,

imidazole, purine, sterane structure). Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid.

Occurrence, biological features, application.

11. Alkaloids II. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine

and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline). Tropane alkaloids ? Alkaloids with a condensed

pyrrolidine- and piperidine cycle. Structure of nortropane, tropane, tropine (3?-hydroxi-tropane) and tropic acid. Atropine,

hyosciamine, scopolamine ? structure, occurrence, biological effect, application in medicine and elsewhere.

12. Alkaloids III. Structure of pseudotropine (3 ?-hydroxi-tropane), ecgonine and cocaine; occurrence and biological effects of cocaine.

Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect.

Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine.

13. Alkaloids IV. Opium alkaloids: Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid. Structure

of morphine; biological effect, medical usage. Structure, biological effects and medical application of some important morphine

derivatives [codeine, tebaine, ethylmorphine (dionine), heroin]. LSD as the most important representative of ergot alkaloids: chemical

structure, biological effects. Biological effects and medical application of further important ergot alkaloids.

14. Alkaloids V. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and caffeine;

occurrence, biological effects, usage. Sterane alkaloids (pseudoalkaloids): chemical structure of tomatidine and solanidin; occurrence

in plants; usage. Occurrence of protoalkaloids with a special structure (colchicine, aristolochic acid) and colouring agents containing

quaternary nitrogen. The most important alkaloid-containing plant families.

15. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of ?-phenyl-propionic acid, trans (E)-

cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic

acid and quinic acid). The hydroquinone ? para-benzoquinone transformation. Quinone derivatives and their significance in plant

biochemistry. Phenol-carboxylic acids of benzoic acid origin (protocatechuic acid, vanillic acid, gallic acid): structure, occurrence in

plants, significance in biology and medicine.

16. Phenoloids II. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid

(Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy. Structure of anise alcohol and anise aldehyde; occurrence in

plants. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivatives: para-coumaryl alcohol,

coniferyl alcohol, sinapyl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

17. Phenoloids III. Coumarins. Chemical structure of coumarin, coumaric acid, aesculin, dicoumarol and furanocoumarins; occurrence

in plants; biological and medicinal significance. Flavonoids: Structure of ?- and ?-pyran, ?- and ?-pyrone and coumarin (?-pyrone

condensed with benzol). Structure of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and

quercetin. Structure, occurrence and isolation of rutin (vitamin P).


36

18. Phenoloids IV. Anthocyanins, anthocyanidins, flavylium salts. Structure of flavylium chloride; some derivatives substituted with

OH-groups. The pH dependence of the colour of flavylium salts; explanation of their behaviour as indicators. Occurrence in plants,

biological effects and medical significance of anthocyanin colouring agents. Tannins. Classification of tannins. Structure of gallic

acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl-?-D-glucose. Occurrence, features and application of tannins.

19. Phenoloids V. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological

effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and

anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective

substances of hop and their structure.

II. Drugs

1. Drugs containing carbohydrates: Mel depuratum, Manna, Pulpa tamarindorum, Rosae pseudo-fructus, Solani amylum, Tritici amylum,

Maydis amylum, Oryzae amylum, Lana gossypii, Agar, Acaciae gummi (Gummi arabicum), Tragacantha, Helianthus tuberosus

2. Drugs containing mucilage-like carbohydrates: Lichen islandicus, Althaeae radix, Althaeae folium, Malvae sylvestris folium et flos,

Salep tuber, Graminis rhizoma, Cyamopsidis tetragonolobae semen, Farfarae folium et flos, Lini semen, Cydoniae semen

3. Carbohydrate-containing drugs stimulating non-specific immune reactions: Echinaceae radix, Eupatorii herba, Arnicae flos, Visci

stipes, Calendulae flos, Tiliae flos, Foenugraeci semen

4. Drugs containing polar, non-polar fats, oils and waxes of plant origin: Lecitin, Ricini oleum virginale, Helianthi annui oleum

raffinatum, Lini oleum virginale, Soiae oleum raffinatum, Carthami oleum raffinatum, Brassicae napae oleum, Arachidis oleum

raffinatum, Butyrum cacao, Jojoba, Cera carnauba

5. Drugs containing essential oil: Menthae piperitae folium, Lavandulae flos, Basilici herba, Orthosiphonis folium, Melissae folium,

Thymi herba, Serpylli herba, Origani herba, Majoranae herba, Saturejae herba, Hyssopi herba, Salviae officinalis folium, Rosmarini

folium, Rosae petalum, Juniperi pseudo-fructus, Camphor, Eucalypti folium, Carvi fructus, Coriandri fructus, Aurantii amari

epicarpium et mesocarpium, Cardamomi fructus, Myrrha

6. Essential oils: Anisi aetheroleum, Aurantii amari floris aetheroleum, Aurantii dulcis aetheroleum, Carvi aetheroleum, Caryophylli

floris aetheroleum, Cinnamomi zeylanici corticis aetheroleum, Citronellae aetheroleum, Coriandri aetheroleum, Eucalypti

aetheroleum, Foeniculi amari fructus aetheroleum, Juniperi aetheroleum, Lavandulae aetheroleum, Limonis aetheroleum, Matricariae

aetheroleum, Melaleucae aetheroleum, Menthae piperitae aetheroleum, Myristicae fragrantis aetheroleum, Pini silvestris

aetheroleum, Rosmarini aetheroleum, Salviae sclareae aetheroleum, Thymi aetheroleum

7. Drugs containing iridoids: Plantaginis lanceolatae folium, Euphrasiae herba, Lamii albi herba, Harpagophyti radix, Agni casti fructus,

Verbenae herba, Valerianae radix, Gentianae radix, Menyanthidis trifoliatae folium, Centaurii herba, Oleae folium

8. Drugs containing sesquiterpenes: Chamomillae romanae flos, Millefolii herba, Matricariae flos, Tanaceti parthenii herba, Cynarae

folium, Absinthii herba, Cardui benedicti herba, Inulae radix, Arnicae flos, Bardanae radix, Cichorii radix et herba, Taraxaci radix et

herba, Pyrethri flos

9. Drugs containing diterpenes and triterpenes: Colophonium, Marrubii herba, Ballotae nigrae herba, Taxi baccatae folium, Liquiritiae

radix, Quillajae cortex, Verbasci flos, Saponariae albae radix, Primulae radix, Polygalae radix, Pruni africanae cortex, Hederae helicis

folium, Betulae folium, Veronicae herba, Ononidis radix, Solidaginis virgaureae herba, Solidagnis herba, Centellae asiaticae herba,

Hippocastani semen, Calendulae flos, Avenae herba, Cimicifugae rhizoma

10. Drugs containing adaptogenic triterpenes, sterols and saponins: Ginseng radix, Eleuterococci radix, Urticae radix et folium, Epilobii

herba, Cucurbitae semen, Dioscoreae tuber, Trigonellae foenigraeci semen, Rusci rhizoma, Sabalis serratulae fructus

11. Drugs containing bufadienolides, cardenolides: Digitalis purpureae folium, Digitalis lanatae folium, Strophanthi semen, Scillae

bulbus, Adonidis herba, Convallariae herba, Nerii folium, Hellebori radix, Leonuri cardiacae herba

12. Drugs containing specific amino acids, amino acid derivatives and amines: Allii sativi bulbus, Allii ursini folium, Allii cepae bulbus,

Bursae pastoris herba, Galegae herba, Phaseoli legumen

13. Drugs containing alkaloids of ornithine and lysine origin: Belladonnae radix et folium, Hyoscyami folium, Stramonii folium, Cocae

folium, Nicotianae folium, Pulmonariae herba, Symphyti radix, Lobeliae herba, Laburni semen, Sarothamni scoparii herba

14. Drugs containing alkaloids of phenylalanine origin: Capsici fructus, Ephedrae herba, Papaveris fructus sine seminibus, Opium

crudum, Chelidonii herba et radix, Fumariae herba, Berberidis radicis cortex, Colchici tuber, Ipecacuanhae radix, Boldi folium,

Tubokurarin-curare

15. Drugs containing alkaloids of tryptophan origin: Secale cornutum, Rauwolfiae radix, Vincae minoris herba, Catharanthi herba,

Strychni semen, Curare, Cinchonae cortex, Uncariae tomentosae radix, Passiflorae herba, Physostigmae semen

16. Drugs containing purine structure effective substances: Coffeae semen, Theae folium, Cacao semen, Guarana, Mate folium, Colae

semen

17. Drugs containing terpenoid alkaloids: Aconiti tuber, Veratri rhizoma et radix, Solani herba

18. Drugs containing cyanogenic glycosides, isothiocyanate derivatives: Amygdalae amarae semen, Lini semen, Sinapis nigrae semen

19. Drugs containing phloroglucin and terpenophenol derivatives: Filicis maris rhizoma, Lupuli flos, Cannabis herba

20. Drugs containing phenol- and phenylpropionic acid derivatives: Cinnamomi cortex, Caryophylli flos, Zingiberis rhizoma, Anisi

fructus, Anisi stellati fructus, Foeniculi dulcis fructus, Calami rhizoma, Petroselini fructus, Balsamum peruvianum, Filipendulae

ulmariae herba, Salicis cortex, Curcumae xanthorrhizae rhizoma

21. Drugs containing quinone- and anthraquinone derivatives, naphthoquinone- and dianthrone derivatives: Uvae ursi folium, Vitis-

idaeae folium, Frangulae cortex, Rhamni purshianae cortex, Rhei radix, Aloe, Juglandis folium, Alkannae radix, Droserae herba,

Lawsoniae folium, Sennae folium et fructus, Hyperici herba

22. Drugs containing coumarins, furocoumarins, lignans and flavanolignans: Meliloti herba, Angelicae radix, Ammeos visnagae fructus,

Ammi majoris fructus, Levistici radix, Apii fructus, Podophylli rhizoma, Silybi mariani fructus

23. Drugs containing flavonoids: Tiliae flos, Sambuci flos, Equiseti herba, Crataegi folium cum flore, Crataegi fructus, Violae herba cum

floris, Ginkgo folium, Stoechados flos, Populi gemma, Propolis, Ribis nigri folium


37

24. Drugs containing tannins, polyphenols: Galla, Quercus cortex, Ratanhiae radix, Hamamelidis folium, Tormentillae rhizoma,

Anserinae herba, Gei radix et rhizoma, Agrimoniae herba, Fragariae folium, Alchemillae herba, Polygoni avicularis herba, Rubi idaei

folium, Rubi fruticosi folium, Coryli folium, Myrtilli folium et fructus, Lythri herba

Participants


38

OPG-O2G-T PHARMACOGNOSY 2 - PRACTICE






Topic








problems, with special emphasis on gathering information from literature, databases and the internet.

Course objective and role in the curriculum: students should become familiar with the general, phytochemical and pharmacological

features of drugs applied in pharmaco- and phythotherapy.

In the European Pharmacopoeia (Ph. Eur.) we can find descriptions of the chemical reactions for identification of plant secondary

metabolites. Practising pharmacists have to know these basic examinations. In the pharmacognosy practices, the students perform these

examinations themselves.


Participation is compulsory on the laboratory practices.

Mid-term exams

There is no possibility to take oral exam if somebody receives failed practice result. Oral exam incudes the practice result. Preparation

of practice nootebook is compulsory. Every week, students need to write written exams. During semester, they need to prepare one

written assay. Practice results includes: written exams, written assay, notebook.


There is possibility to make up for the missed practices but with the course supervisor’s permission.

Reading material



Bencsik T, Ács K, Farkas Á, Molnár P, Papp N, Horváth Gy: Pharmacobotanical and phytochemical investigations of herbal drugs,

teaching supplement, 2015

- Notes


Lectures

Practices

1 Alkaloid-containing drugs I. Solanaceae. Comparison of Belladonnae folium and Stramonii folium on the basis of cleared

preparations. Examination of Capsici fructus.





4 Alkaloid-containing drugs II. Microscopic identification of Boldi folium, Chelidonii herba and Papaveris rhoeados flos.



7 Drug identification test 3. (WRITTEN EXAM) Drugs containing flavonoids. Equiseti herba contamination with Equisetum

palustre – analysis of the epidermis and other morpho-anatomical features.





10 Written test. Analysis of drugs containing alkaloids. Extraction and detection of nicotine and caffeine. Soxhlet-extraction

(demonstration)


39


(demonstration)


(demonstration)

13 Written test. Detection of phenoloids by thin layer chromatography.



16 Analysis of drugs containing flavonoids. Quantitative determination of total flavonoid content according to Ph. Eur. Students’

short lectures (homework)





19 Drugs containing anthraquinones, coumarins, and tannins. Characterisation of Lythri herba and Cotini folium.



22 Written test. Analysis of drugs containing anthranoids according to Ph. Eur.



25 Other drugs containing therapeutically important active compounds.



28 Written test. Analysis of drugs containing tannins. Quantitative determination of total tannin content according to Ph. Eur.



31 Drug identification test 4. (ORAL EXAM!)



34 Analysis of drugs containing saponins. Problem-based tasks, case studies from the pharmacy (homework).



37 Identification of components of unknown tea mixtures. Preparation of herbal teas of FoNo VII.



40 Summary of the drug identification.



Seminars


Not relevant.

Participants

Dr. Ács Kamilla (EWOCN2), Dr. Horváth Adrienn (IUT27D)


40

OPG-R2E-T PHARMACEUTICAL CHEMISTRY 2 - THEORY



2 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 6



Topic

Introduction to the pharmacokinetics and pharmacodynamics of drug action. Molecular aspects and structure activity relationship of

selected groups of active pharmaceutical ingredients with central nervous system activity.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the

practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Two compulsory midterm tests (on

the topics of the lectures and practices) will be written during the semester on the 7th and the 12th weeks. Both of the test result should

be above 60%. Students can have one retake per midterm test. Students have to write at least four mini-tests on the practices. The average

of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical

grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Mid-term exams

If the student did not take part writing the midterm test, she or he can participate the retake, only. There is no chance for extra possibilities.


There is no opportunity to make up missed classes.

Reading material


D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins,

Philadelphia, 2013

Lecture notes




- Notes

Pharmaceutical Chemistry Practice I, Laboratory manual, University of Pécs, 2015



Lecture notes.

Lectures

1 Sedatohypnotics and anxiolytics.


2 Sedatohypnotics and anxiolytics.


3 Antipsychotics.


4 Antipsychotics.


5 Antidepressants.


6 Antidepressants.


7 Antiepileptics and central muscle relactants.


8 Antiepileptics and central muscle relactants.


9 Antiparkinson agents.



41

10 Antiparkinson agents.


11 Parasympathomimetics

Dr. Perjési Pál

12 Parasympathomimetics

Dr. Perjési Pál

13 Parasympatholytics

Dr. Perjési Pál

14 Parasympatholytics

Dr. Perjési Pál

15 Sympathomimetics

Dr. Perjési Pál

16 Sympathomimetics

Dr. Perjési Pál

17 Sympatholytics

Dr. Perjési Pál

18 Sympatholytics

Dr. Perjési Pál

19 Antipyretics, Non-steroid analgetics, Anti-inflammatory agents I.

Dr. Almási Attila

20 Antipyretics, Non-steroid analgetics, Anti-inflammatory agents I.

Dr. Almási Attila

21 Antipyretics, Non-steroid analgetics, Anti-inflammatory agents II.

Dr. Almási Attila

22 Antipyretics, Non-steroid analgetics, Anti-inflammatory agents II.

Dr. Almási Attila

23 Local anesthetics.

Dr. Almási Attila

24 Local anesthetics.

Dr. Almási Attila

25 Peripheral muscle relactants.

Dr. Almási Attila

26 Peripheral muscle relactants.

Dr. Almási Attila

27 Drugs of gastrointestinal disorders.

Dr. Almási Attila

28 Drugs of gastrointestinal disorders.

Dr. Almási Attila

Practices

Seminars


Oral exam covering the topics of the subjects Pharmaceutical Chemistry 2 and selected topics of Pharmaceutical Chemistry 1. Before the

exam students should have a Minimum Requirement Test of which result should be at least 80%. Information on the topics of the

Minimum Requirement Tests and the list of questions of the find exam is available on the home page of the Institute.

Participants


42

OPG-R2G-T PHARMACEUTICAL CHEMISTRY 2 - PRACTICE






Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Pharmacopoeal analysis of selected inorganic

substances.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory.

Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must

be at least 50%. Quantitative measurements should be carried out with the acceptance level of 70%! The practical work (results of the

written tests and the experimental work) is evaluated by a practice grade.

Mid-term exams

The short practical test can be made up on the next practical.


There is no opportunity to make up missed practices.

Reading material





- Notes

Pharmaceutical Chemistry Practice I, Laboratory manual, University of Pécs, 2015



Lectures

Practices

1 Pharmacopoeial nomenclature of organic substances. Alcohols. Paraffinum liquidum (Ph. Hg. VII), Vaselinum album (Ph. Hg.

VII), Alcoholum dilutum 70% (Ph. Hg. VII) Terpinum (Ph. Hg. VII). Glycerolum, Mannitolum.







5 Phenols. Terpinum (Ph. Hg. VII), Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph. Hg. VII).




9 Amines. Methenaminum, Cholinum chloratum (Ph. Hg. VII), Triethanolaminum (Ph. Hg. VII)




13 Aldehydes and ketones. Formaldehydi solutio, Chlorali hydras.




17 Carbohydrates. Fructosum, Glucosum anhydricum, Lactosum, Saccharum.




43


21 Carboxylic acids. Acidum aceticum dilutum 20% (Ph. Hg. VII.), Acidum lacticum, Acidum citricum, Acidum oleicum, Acidum

sorbicum, Acidum tartaricum.







25 Amino acids, peptides, proteins. Acidum glutamicum. Acidum asparticum.




29 Carbonic acid derivatives, Keto-enol and lactam-lactim tautomerism. Barbiturates. Ureum, Urethanum (Ph. Hg. VII), Barbitalum,

Barbitalum natricum.







33 Theophyllinum, Coffeinum, Theobromimum, Theobrominum natrium salicylicum (Ph. Hg. VII).




37 Tropanoids I-II. (Seminar). Atropini sulfas. Homatropini hydrobromidum.




41 Acidum benzoicum, Acidum saliylicum, Acidum acetylsalicylicum. Natrii salicylas, Salicylamidum (Ph. Hg. VII).




45 Azophenum, Noraminophenazonum, Aminophenazonum, Paracetamolum.




49 Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum.




53 Identification and complete pharmacopoeial analysis of an organic substance.




Seminars


Questions of the above short tests are from the topics of the practical and seminary.

Participants

Dr. Almási Attila (KJ5MBZ)


44

OPO-I2E-T MICROBIOLOGY 2 - THEORY



2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 6



Topic

Systematic bacteriology, virology, mycology and parasitology are the main subjects of the second semester. The course is completed by

a block of lectures integrating the knowledge using a clinical microbiological approach.. The objective is to provide solid knowledge on

the prevention and therapy of infectious diseases.


Mid-term exams

--


Reading material


Denyer SP ,Hodges NA, Gorman SP, Gilmore BF: Hugo and Russells Pharmaceutical Microbiology, 8th Edition, Blackwell Science

Ltd 2018. ISBN: 978-1-119-43449-8

Tim Sandle: Pharmaceutical Microbiology : Essentials for Quality Assurance and Quality Control, ELSEVIER SCIENCE &

TECHNOLOGY , Woodhead Publishing Ltd, 2015 ISBN10 0081000227


Lectures on the Neptun

- Notes


Dr. Patrick R. Murray, Dr. Ken S. Rosenthal and Dr. Michael A. Pfaller (eds.): Medical Microbiology, 8th edition, Elsevier Saunders 2020

F.H. Kayser, K.A. Bienz, J. Eckert, R.M. Zinkernagel: Medical Microbiology, Thieme Stuttgart 2005, ISBN: 3-13-131991-7

Lectures

1 Pathogens in respiratory tract

Dr. Emődy Levente

2 Pathogens in respiratory tract

Dr. Emődy Levente

3 Aerobic and anaerobic spore-forming bacteria

Dr. Kocsis Béla

4 Anaerobic bacteria


5 Gram-negative nonfermenters

Dr. Emődy Levente

6 Mycobacteria

Dr. Emődy Levente

7 Anti-mycobacterial drugs

Dr. Mestyán Gyula

8 Spirochaetes

Dr. Kocsis Béla

9 Rickettsia, Chlamydia


10 Zoonosis


11 Characterization of viruses (basic concepts, structure, chemical composition, classification). Multiplication of viruses (modes of

replication, mutants, interaction between viruses)

Dr. Reuter Gábor Kamilló

12 Pathogenesis of virus infections (modes and types of infection, immunity)

Dr. Szereday László


45

13 Adenovirus, Parvovirus (Erythrovirus B19)


14 Herpesviruses, Hepatitis viruses


15 Papovaviruses, Polyomaviruses, Poxviruses, Slow virus infections, Prions


16 Arboviruses, Roboviruses, Rhabdoviruses


17 Respiratory viruses (orthomyxo-, Paramyxovitruses, Coronaviruses, RSV, Rhinoviruses)


18 Enteric viruses


19 Retroviruses (HTLV-I, HTLV-II., HIV/AIDS)


20 Prophylaxis of virus infections, chemotherapy (conventional and new vaccines, antiviral compounds, interferon)


21 Mycology I

Dr. Mestyán Gyula

22 Mycology II

Dr. Mestyán Gyula

23 Antimycotics

Dr. Mestyán Gyula

24 Parasitology I

Dr. Kocsis Béla

25 Parasitology II

Dr. Kocsis Béla

26 Antiparasitic drugs

Dr. Mestyán Gyula

27 Nosocomial or iatrogenic infections I


28 Nosocomial or iatrogenic infections II


Practices

Seminars


At the end of second semesters the students will sit for written examinations (MCQ) in microbiology. The subject of the examinations is

the information provided on the lectures during the first and second semesters.

Participants


46

OPO-I2G-T MICROBIOLOGY 2 - PRACTICE



2 credit ▪ midsemester grade ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 6



Topic

The objective is to provide solid knowledge of microbiological diagnostic methods, sterility tests. During the practices the student can

acquire the skill of aseptic technique in the field of microbiology and pharmacology.



Mid-term exams

End of the course the students will take a lab practice exam.


Consultation with supervisor

Reading material


Denyer SP ,Hodges NA, Gorman SP, Gilmore BF: Hugo and Russells Pharmaceutical Microbiology, 8th Edition, Blackwell Science Ltd

2018. ISBN: 978-1-119-43449-8

Tim Sandle: Pharmaceutical Microbiology : Essentials for Quality Assurance and Quality Control, ELSEVIER SCIENCE &

TECHNOLOGY, Woodhead Publishing Ltd, 2015 ISBN10 0081000227


- Notes

Website of the department


Dr. Patrick R. Murray, Dr. Ken S. Rosenthal and Dr. Michael A. Pfaller (eds.): Medical Microbiology, 9th edition, Elsevier Saunders

2020 ISBN13 (EAN): 9780323673228

Lectures

Practices

1 Introduction, safety regulations. The microscope, native and stained preparations

Dr. Mestyán Gyula

2 Introduction, safety regulations. The microscope, native and stained preparations

Dr. Mestyán Gyula

3 Cultivation of bacteria, media and techniques.


4 Cultivation of bacteria, media and techniques.


5 Identification of bacteria

Dr. Melegh Szilvia Zsóka

6 Identification of bacteria

Dr. Melegh Szilvia Zsóka

7 Serological methods in microbiology. Immunotherapy.


8 Serological methods in microbiology. Immunotherapy.


9 Molecular methods in clinical microbiology


10 Molecular methods in clinical microbiology


11 Sterilisation and disinfection, Sterility and pyrogen testing methods. Demonstration of the effect of disinfectants on skin flora

Dr. Kocsis Béla


47

12 Sterilisation and disinfection, Sterility and pyrogen testing methods. Demonstration of the effect of disinfectants on skin flora

Dr. Kocsis Béla

13 Antibiotic sensitivity (Kirby-Bauer method, MIC, MBC, E-test)


14 Antibiotic sensitivity (Kirby-Bauer method, MIC, MBC, E-test)


15 Antibiotic concentration in body fluids. Detection of enzymes and compounds which neutralize antibiotics. Interactions of

antibiotics

Dr. Mestyán Gyula

16 Antibiotic concentration in body fluids. Detection of enzymes and compounds which neutralize antibiotics. Interactions of

antibiotics

Dr. Mestyán Gyula

17 Diagnosis of bacterial wound infection. Sepsis - blood culture

Dr. Tigyi Zoltán

18 Diagnosis of bacterial wound infection. Sepsis - blood culture

Dr. Tigyi Zoltán

19 Microbiological diagnosis of gastrointestinal infections

Dr. Tigyi Zoltán

20 Microbiological diagnosis of gastrointestinal infections

Dr. Tigyi Zoltán

21 Microbiological diagnosis of urinary tract infections


22 Microbiological diagnosis of urinary tract infections


23 Microbiological diagnosis of respiratory tract infections

Dr. Mestyán Gyula

24 Microbiological diagnosis of respiratory tract infections

Dr. Mestyán Gyula

25 Microbiological diagnosis of fungal and parasitic infections

Dr. Mestyán Gyula

26 Microbiological diagnosis of fungal and parasitic infections

Dr. Mestyán Gyula

27 Methods used in diagnostic virology


28 Methods used in diagnostic virology


Seminars


Exam questions are based on lab practices.

Participants

Dr. Bátai Istvánné (Dr. Kerényi Mónika) (A6M8OA), Dr. Kocsis Béla (TDMDDX), Dr. Melegh Szilvia Zsóka (VUXN5M), Dr. Mestyán

Gyula (DNCE8M), Dr. Schneider György (Y295EC), Dr. Szereday László (QN9T0F), Dr. Tigyi Zoltán (IMRVFK), Zsoldiné Dr. Urbán

Edit (KZSC8O)


48

OPO-KTN-T PATHOPHYSIOLOGY

Course director: DR. JÁNOS GARAI, associate professor

Institute for Translational Medicine [email protected]

5 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 6



Topic

The main goal of the curriculum is to introduce the students on a preclinical level to the basic dysfunctions of individual organs and

organ systems, to make them acquainted with the inherited and acquired etiological factors, with the pathogenesis and pathomechanism

of diseases, and with the possible compensatory or adaptive mechanisms and system interactions.

The topics covered (among others) include pathophysiologic aspects of circulation, respiration, energy homeostasis, thermoregulation,

renal-, endocrine-, gastrointestinal functions, acid-base and salt-water balance with special focus on pathomechanisms fundamentally

linked to target sites of the most prescribed drugs as well as on iatrogenic risks in connection with the main- and side-effects of drugs.

Since the mean age of the patients is growing higher in most parts of the world, the gerontological aspects of functional changes are

embedded into the curriculum throughout the course. The course is important to understand the clinical symptoms, as well as the possible

pharmacological or other interventions and steps of prevention.


Max. 3 misses from seminars (15%/28) can be tolerated.

On the interim written test (ZH) a 50% achievement is the precondition for entering the oral exam.

The person(s) not achieving 50% or not participating at the interim test must answer 10 Minimum Questions within 10 minutes in writing

just prior to the oral exam. 80% achievement is the precondition for entering the exam.

Passing the minimum questions in this case, however, is only a prerequisite, but is not sufficient on its own for a successful exam.

Mid-term exams

Egyéni


Writing an essay from the topic of the missed seminar

Reading material


Basically the knowledge of topics dealt with at the lectures and seminars is the requirement at the exams.

- Prof. Miklós Székely (ed.): Basic Principles of Pathophysiology, department notes for medical students, 2006,

- S. Silbernagl, F. Lang: Color Atlas of Pathophysiology, Thieme Stuttgart; New York, 2000 (useful for final preparation)

- Martin M. Zdanowicz: Essentials of Pathophysiology for Pharmacy, CRC Press 2002

Handouts on http://www.pote.hu/index.php?page=egyseg&egy_id=150&menu=okt_anyag&nyelv=eng







- Notes












http://www.pote.hu/index.php?page=egyseg&egy_id=150&menu=okt_anyag&nyelv=eng





49

Lectures

1 The contextual position of Pathophysiology in pharmacists? curriculum

Dr. Garai János

2 Health and disease. Pathogens, disease course, symptoms, prognosis, therapy, prevention etc.

Dr. Garai János

3 Inflammation & injury

Dr. Garai János

4 Pathophysiology of coronary circulation I

Dr. Garai János

5 Pathophysiology of coronary circulation II

Dr. Garai János

6 Disorders of cerebral circulation

Dr. Garai János

7 Regulation of blood pressure, its abnormalities, hypertension

Dr. Garai János

8 Consequences of hypertension, and prevention thereof

Dr. Garai János

9 Heart failure (central circulatory failure)

Dr. Garai János

10 Peripheral circulatory failure (shock)

Dr. Garai János

11 Sepsis (SIRS)

Dr. Garai János

12 Multiple organ dysfunction/failure (MODS, MOF)

Dr. Garai János

13 Disorders of the control of breathing. Sleep apnea syndrome

Dr. Garai János

14 Pathophysiology of ventilation mechanics. Obstructive & restrictive disorders

Dr. Garai János

15 Abnormalities of gas exchange

Dr. Garai János

16 Respiratory failure, forms of tissue hypoxia.

Dr. Garai János

17 Dyspnea

Dr. Garai János

18 Pathophysiology of physical exercise

Dr. Garai János

19 Acid-base disorders: the role of buffers

Dr. Garai János

20 Role of breathing and the kidney in anomalies of pH-homeostasis

Dr. Garai János

21 Basic mechanisms of glomerular and tubular function anomalies

Dr. Garai János

22 Forms of acute renal failure

Dr. Garai János

23 Mechanisms of chronic renal failure

Dr. Garai János

24 Uraemia, uraemic coma

Dr. Garai János

25 Disorders of thermoregulation: introduction / fever

Dr. Garai János

26 Disorders of thermoregulation: fever & hyperthermia, heat shock

Dr. Garai János

27 Hypothermia

Dr. Garai János

28 Energetic balance, nutritional status, starvation (total/partial), malnutrition

Dr. Garai János


50

29 Obesity, metabolic syndrome

Dr. Garai János

30 Diabetes mellitus (DM) syndrome: definition, classification

Dr. Garai János

31 Pathogenesis of DM syndromes

Dr. Garai János

32 Acute complications of DM

Dr. Garai János

33 Chronic complications of DM

Dr. Garai János

34 Disorders of the hypothalamo-pituitary system and pathophysiology of growth

Dr. Garai János

35 Thyroid gland disorders

Dr. Garai János

36 Adrenal gland dysfunctions

Dr. Garai János

37 Disorders of swallowing, filling- and emptying of the stomach, vomiting.

Dr. Garai János

38 GI tract disorders: ileus, malabsorption diarrhea, constipation

Dr. Garai János

39 Pancreatic disorders

Dr. Garai János

40 Pathophysiology of liver function, liver damage

Dr. Garai János

41 Forms of icterus

Dr. Garai János

42 Portal hypertension, ascites, hepatic coma

Dr. Garai János

Practices

Seminars

1 The contextual position of Pathophysiology in pharmacists' curriculum

2 Health and disease. Pathogens, disease course, signs & symptoms, therapy, prevention

3 ECG analysis, basic aspects

4 Common anomalies of repolarisation

5 ECG of acute myocardial infarct

6 Abnormal impulse formation

7 Abnormal impulse conduction

8 Complex ECG-abnormalities

9 Theory of respiratory function tests

10 Demonstration of respiratory function tests in practice

11 Acid-base balance, functionality of defense systems, major challenges

12 Acid-base disorders

13 Salt-water balance (Osmo- & volume homeostasis), the regulators and effectors

14 Disorders of salt-water balance

15 Disorders of metabolism I: Lipoproteins, hyperlipidemias, atherosclerosis

16 Disorders of metabolism II: Abnormal aminoacid metabolism, hyperuricemia, gout

17 Potassium homeostasis

18 Hyperkalemias, hypokalemias

19 Pathophysiology of vitamins and trace elements

20 Hypo- & hypervitaminoses

21 Disorders of Ca, P homeostasis, osteoporosis, osteomalacia

22 Vitamin-D, parathormone, hypo- & hypercalcemia

23 Anaemia, polycythemia

24 Disorders of hemostasis, DIC

25 Disorders of swallowing, filling- and emptying of the stomach, vomiting.

26 GI tract motility problems I: Diarrhea, constipation

27 GI tract motility problems II: ileus / Malabsorption syndromes

28 Pre-exam discussion of particular questions requested by the students.


51


“A” exam is absolved by filling out a test based on the exam questions. “B” and “C” exams are absolved orally with answering three

questions drawn.

Pathophysiology of water-soluble vitamins and trace elements

Pathophysiology of fat-soluble vitamins

Complete starvation

Partial starvation, accelerated forms of energetic insufficiency, anorexia nervosa

Obesity: criteria, classification, epidemiology, etiology and pathogenesis. Metabolic syndrome

Protein deficiency, protein-calorie malnutrition, senile sarcopenia

Pathobiochemistry of LDL-metabolism, hyperlipoproteinemias

Hypoglycemias

Etiology and pathogenesis of DM1.

Etiology and pathogenesis of DM2.

Diabetic coma (ketoacidotic & hyperosmolar forms)

Late complications of diabetes mellitus (including pathobiochemistry thereof)

Pathophysiology of the pituitary, anomalies of growth

Hyperthyroidism

Hypothyroidism

Glucocorticoid hyperfunctional states

Pathophysiological aspects of glucocorticoid therapy

Adrenal (cortex) insufficiency

Hyperaldosteronisms

Hyper- and hypocalcemia

Osteoporosis, osteomalacia

General pathophysiology and consequences of anemias and polycythemia

Deficiency anemias

Aplastic anemias

Hemolytic anemias

Congenital and acquired coagulopathies

Bleeding abnormalities due to vascular factors

Disorders of platelet functions

Disseminated intravascular coagulation

Thrombophilia, thrombosis: causes and consequences

Pathophysiology of peptic ulcer

Disorders of gastric filling and emptying, vomiting

Malabsorption syndromes

Diarrhea: causes, pathophysiological forms, consequences

Bowel obstruction (ileus)

Obstipation, diverticulosis

Jaundice (conjugated & non-conjugated hyperbilirubinemias)

Pathophysiological aspect of hepatic detoxifying system

Toxic- and idiosynchratic liver damage

Hepatic coma

Liver cirrhosis, portal hypertension, ascites

Pancreatitis (acute & chronic): pathophysiology and consequences.

Hypothermia

Heat stroke, malignant hyperthermia

Pathophysiology of fever, its biological value, basic aspects of antifebrile strategies

Inflammation, forms of manifestation, basic pathomechanisms

Main groups and important representatives of inflammatory mediators

Systemic inflammatory response syndrome (SIRS), multiple organ failure (MOF)

Metabolic acidosis and alkalosis: causes, compensation, consequences

Respiratory acidosis and alkalosis: causes, compensation, consequences

Hyperkalaemia

Hypokalaemia

Mechanisms and disorders of volume regulation, abnormal distribution of extracellular fluid (edema)

Mechanisms and disorders of osmoregulation, states with hypo- and hypertonicity


52

Cardiovascular adaptation to physical exercise in healthy persons and patients with heart disease

Pathophysiology of coronary insufficiency, risk factors

Pathomechanism and consequences of acute myocardial infarction (AMI)

Pathophysiology of heart failure

Cardiomyopathies

Cerebral hypoxia, ischemia, stroke

Pulmonary hypertension.

General pathophysiology and classification of systemic hypertension

Primary (essential) hypertension: characteristics, etiological factors, consequences

Hypertension and the kidneys (reciprocal connection)

Hypertension and the adrenal gland

Vasovagal syncope and other states with hypotension

Circulatory shock: definition, classification, pathophysiology, phases and characteristics of microcirculation

Hypovolemic shock

Distributive shock

Cardiogenic shock

Forms of extrasystole (premature beats)

Pre-excitation syndromes, forms and consequences of paroxysmal tachycardia

Flutter and fibrillation: atrial and ventricular

Nomotopic and passive heterotopic abnormalities of impulse formation

Abnormalities of atrioventricular conduction (AV blocks)

Intraventricular conduction abnormalities (bundle branch blocks)

Atrial and ventricular axis deviations

Primary repolarization abnormalities in the ECG: ECG in angina pectoris and acute myocardial infarction

Disorders of the control of breathing. Sleep-apnea syndrome (OSAS, CSAS)

Causes and consequences of increased airway resistance, chronic obstructive pulmonary disease (COPD)

Alveolar hypoventilation and hyperventilation, causes and consequences

Forms and mechanisms of hypoxia, ways of compensation, cyanosis

Disorders of oxygen transport (abnormal hemoglobin, CO-poisoning, methemoglobinemia)

Partial and complete respiratory failure, dyspnea

Principles of basic respiratory function tests, parameters of restrictive and obstructive breathing mechanics

Pathophysiology of glomerular filtration

Disorders of tubular functions

Acute renal failure: causes, forms, general and specific features

Chronic renal failure: causes, characteristics and progression

Uraemia

Hyperuricemia, gout

Disturbances of amino acid metabolism, (phenylketonuria, hyperhomocysteinaemia etc.)

Participants

Dr. Garai János (ZUFUFE), Dr. Garami András (JHGYAO), Dr. Soós Szilvia (H8YUDE), Dr. Varjú-Solymár Margit (E6UVQB)


53

OPR-SG2-T PROFESSIONAL PRACTICE 2

Course director: DR. ANDRÁS TAMÁS FITTLER, associate professor

Department of Pharmaceutics and University Pharmacy [email protected]

0 credit ▪ signature ▪ Criterion requirement subject ▪ spring semester ▪ recommended semester: 6



Topic

After the 6. semester the students should complete a summer professional practice in a community pharmacy and hospital pharmacy

(host institution) to acquire the basic knowledge regarding the pharmaceutical supply and care in these settings. After the completion of

the professional practice the student will have an overview of the operation and pharmaceutical procedures of the community or hospital

pharmacy.

Furthermore the professional practice can be completed in a pharmaceutical company, pharmaceutical wholesaler or foreign (non

Hungarian) units equivalent to these. To fulfill the professional practice in abroad the student should submit a written request to the

course director until the deadline of the application for professional practice. In case of spending the professional practice abroad it is

advisable for the students to spend 2 weeks in a Hungarian pharmacy to earn experiences regarding the Hungarian pharmacies.

It is possible to complete the 4 weeks of the professional practice in two practice sites in consecutive 2-2 weeks. The application form,

syllabus and certificate of the completion of the professional practice are available from the website of the Registrars Office.

The accreditation of the professional practice site (pharmacy) is advisable but not a mandatory requirement for professional practice 1.

and 2.

The organization and coordination/reconciliation of the place and time of the professional practice is the responsibility of the student.

Before starting the professional practice the student should fill the Acceptance letter for professional practice form and collect signatures

of supervisor pharmacist and the leader or head of the professional practice site (pharmacy, company) and upload it electronically to

Neptun. It is advisable to collect the document until the last day of April, but latest by 14th of May. The student is responsible to fulfill

the administrative criteria set by the Registrar's Office.

The duration of the professional practice is 4 weeks, 8 hours daily, of which 2 hours may be spent on individual preparation and study.

During the professional practice attendance should be recorded on an attendance sheet, which is available from the website of the

Registrars Office. The requirement regarding the opening hours of the pharmacy is 8 hours daily. The student should work under the

supervision of the supervisor pharmacist or the deputy pharmacist during the whole practice and preparing a record daily of his or her

work.

The record of the practice is accepted by the course director. The record should include (see inscructions on RO website in "Report

writing guide for Professional Practice 1. and 2."):

- written notes of daily practice/activity,

- furthermore the topics listed in the syllabus and the completion of 2 related professional problems described in minimum 400 words of

each.

After the completion of the professional practice the student can evaluate the professional practice site and the supervisor pharmacist.


Before starting the professional practice student should have a semester acceptance of Pharmaceutical technology 1.. Student should

transmit the attendance sheet, record of practice and the completion of the professional practice to the acceptance of the professional

practice. At the end of the professional practice the supervisor pharmacist or the deputy pharmacist evaluates the performance of the

student in a three-grade evaluation with written summary. The student is responsible to fulfill the administrative criteria set by the

Registrars Office.

Students should wear White coat and Protective shoes during practice.

The original written documents of the practice must be presented by the student upon the request of the course director within 5 working

days.

Mid-term exams

The duration of the professional practice is 4 weeks, 8 hours daily, of which 2 hours may be spent on individual preparation and study.

During the professional practice attendance should be recorded on an attendance sheet, which is available from the website of the

Registrars Office. The requirement regarding the opening hours of the pharmacy is 8 hours daily. The student should work under the

supervision of the supervisor pharmacist or the deputy pharmacist during the whole practice and preparing a record daily of his or her

work.

The organization and reconciliation of the place and time of the professional practice is the responsibility of the student. Before starting

the professional practice the student should fill the acceptance letter for professional practice form and collect signatures of supervisor

pharmacist and the leader or head of the professional practice site (pharmacy, company) and pass to the Registrars Office until the last

day of April.


The absence during the professional practice should be covered with a certificate (e.g.: in case of illness) to the supervisor pharmacist

and course director and should make up during the period of the professional practice. In case of health problems the professional practice

can be divided into 2-2 weeks.


54

Reading material



Plese see the following on the RO website (http://gytk.pte.hu/en/egyseg/almenu/3030/358, accessed 2021 February)

General information and user's guide to the Professional Practice 1-2. registartions in Neptun

Report writing guide for Professional Practice 1. and 2.

Planned schedule of blocks (weeks) in Neptun for the Professional Practice 1-2.

- Notes

The Theory and Practice of Pharmaceutical Technology



Pharmacopoeia Hungarica

Hungarian National Formulary: Formulae Normales VII (FoNo VII)

Compendium

Lectures

Practices

Seminars


COMMUNITY PHARMACY

1. Getting to know pharmacy workflows.

2. Evaluation of extemporaneous prescriptions, preparation of liquids and semi-solid dosage forms under supervision of the pharmacist.

3. Receipt and analysis of raw materials, the rules and practice of impleation.

4. Handling weighs, pharmacy tools and machines.

5. The rules and practice of aseptic compounding and dispensing of aseptic medicines.

6. The rules, practice and documentation of large scale compounding

7. Nomenclature, synonyms, abbreviations and formulas

8. Getting to know the formulas in the Hungarian National Formulary of extemporaneous medicines (Formulae Normales - FoNo.)

9. The recognition and handling of technological incompatibilities.

10. Certified and official pharmaceutical documentation (e.g.: laboratory log, controlled drug records, log of sterilizing, etc.).

11. Pharmaceutical publications.

12. Medical aids and dressings.

13. Competencies and workflow of pharmaceutical assistants in a pharmacy.

PHARMACEUTICAL INDUSTRY

14. The role of pharmaceutical company in the drug supply chain.

15. The organogram and key peaople of pharmaceutical company.

16. The Good Manufacturing Practice (GMP): regulations and application.

17. Participating in the manufacturing process.

18. Getting familiar with the operation and role of Quality Assurance and Quality Control.

19. Getting familiar with the operation and role of Quality Assurance and Quality Control.

20. The role of microbiology in the pharmaceutical company.

21. Special operation characteristics of a pharmaceutical company.

HOSPITAL & CLINICAL PHARMACY

22. Regulations of the hospital and clinical drug supply.

23. Basic and special tasks in the hospital pharmacy.

24. Participation of the hospital pharmacy in the committees and workgroups of the hospital (e.g.: Therapeutic committee, infectology

and nutrition therapy, etc.).

25. Pharmaceutical management, the relationship with wholesalers, drug utilization.

26. Drug information, Therapy management and drug information sources, databases.

27. Authorized drugs, nutraceutical, dietary supplements and other non medication products

28. Handling and documentation of controlled drugs and substances.

Participants

http://gytk.pte.hu/en/egyseg/almenu/3030/358

STUDY PROGRAM 2021/2022 Subjects of the 5-6. semesters ...

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