STUDY PROGRAM 2017/2018 Subjects of the 3-4. semesters...

UP FP Pharmacy major – obligatory subjects of the 3-4. semester - Course descriptions – academic year of 2017/2018

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University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2017/2018

Subjects of the 3-4. semesters

(obligatory subjects and criterion requirements)


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3rd semester

OPA-FZ2 ________ Physical Chemistry 2 ______________________________________________________________________ 3

OPA-KD1 _______ Colloidics 1 ______________________________________________________________________________ 5

OPA-V1E ________ Organic Chemistry 1 - Theory _______________________________________________________________ 7

OPA-V1G _______ Organic Chemistry 1 - Practice ______________________________________________________________ 10

OPO-AI2 ________ Human Anatomy, Histology and Embriology 2 _________________________________________________ 12

OPO-G1E ________ Pharmacobotany 1 - Theory ________________________________________________________________ 14

OPO-G1G _______ Pharmacobotany 1 - Practice ________________________________________________________________ 16

OPO-H1E ________ Human Physiology 1 - Theory ______________________________________________________________ 18

OPO-H1G _______ Human Physiology 1 - Practice ______________________________________________________________ 23

ATT3 ___________ Physical Education 3 ______________________________________________________________________ 27

4th semester

OPA-G1B _______ Pharmaceutical Biochemistry 1 _____________________________________________________________ 28

OPA-M1E _______ Instrumental Analysis - Theory ______________________________________________________________ 30

OPA-M1G _______ Instrumental Analysis - Practice _____________________________________________________________ 32

OPA-V2E ________ Organic Chemistry 2 - Theory ______________________________________________________________ 34

OPA-V2G _______ Organic Chemistry 2 - Practice ______________________________________________________________ 38

OPG-GI1 ________ Basic Principles of Pharmacy _______________________________________________________________ 40

OPO-G2E ________ Pharmacobotany 2 - Theory ________________________________________________________________ 42

OPO-G2G _______ Pharmacobotany 2 - Practice ________________________________________________________________ 44

OPO-H2E ________ Human Physiology 2 - Theory ______________________________________________________________ 46

OPO-H2G _______ Human Physiology 2 - Practice ______________________________________________________________ 52

ATT4 ___________ Physical Education 4 ______________________________________________________________________ 57

ATT1-2-3-4-5 ____ Physical Education courses 1-2-3-4-5 _________________________________________________________ 58

OPR-SG1 ________ Professional Practice 1 ____________________________________________________________________ 61

OPR-HUF-O _____ Final Examination in Hungarian Pharmaceutical Terminology - oral ________________________________ 63

OPR-HUF-W _____ Final Examination in Hungarian Pharmaceutical Terminology - written ______________________________ 64


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OPA-FZ2 PHYSICAL CHEMISTRY 2

Course director: DR. SÁNDOR KUNSÁGI MÁTÉ, associate professor

Faculty of Natural Sciences - Department of General and Physical Chemistry

3 credit ▪ midsemester grade ▪ Basic subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 0 lectures + 42 practices + 0 seminars = total of 42 hours

Course headcount limitations (min.-max.): 4 – 36 Prerequisites: OPA-FZ1 completed

Topic

The students completing the course will get experience in carrying out basic physical chemical measurements. They will learn the ways

of handling instruments, taking notes, evaluating experimentally taken data. Before the practice each student obtains an experimental

task to be solved. In home reading they refresh the theoretical back ground and study the instructions. Before beginning the laboratory

work they complete a short test to prove their level of understanding the theory and practice of the task to be solved. They work alone

following the written instructions and guidelines of the instructor. The data, calculations, graphs, tables and conclusions are introduced

into a carefully prepared note book. The tasks are taken from chapters of physical chemistry studied in course Physical chemistry I:

Thermo dynamics, reaction kinetics, electro chemistry, equilibrium, properties of solutions, determination of indicator exponents.

Different instruments like electrochemical work stations, spectro photometers, calorimeters, gas volume measurements, conductometric

apparatus, pH meter and other basic „small” laboratory equipment are used.

Conditions for acceptance of the semester

Maximum of 10 % absence of practices allowed.

Mid-term exams

Two tests per semester will be performed.

Making up for missed classes

One week absence can be tolerated if the experiment is performed in a supplementary time (last week)

Reading material

- Obligatory literature

P.J. SINKO: Martin’s Physical Pharmacy and Pharmaceutical Sciences, Lippincott Williams & Wilkins, Philadelphia, 2011

P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722

- Literature developed by the Department

The description of the experimental work is given in the home page of the department

- Notes

The description of the experimental work is given in the home page of the department

Laboratory manual downloaded from the web site of the Dept. for General and Physical Chemistry of Faculty of Sciences at the

University of Pécs

- Recommended literature

D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2

Lectures

Practices

1 Determination of solubility, calculation of the differential dissolution heat



2 Investigation of the behavior of terner (three component) systems, preparation solubility triangle diagram



3 Investigation of the behavior Reaction heat measurement using adiabatic calorimeter



4 Investigation of kinetics of hydrolysis with conductometryc measurements



5 Investigation of decomposition kinetics of a drug molecule




4

6 Investigation of homogeneous catalysis (oxidation of ascorbic acid)



7 Study of drug dissolution kinetics from pharmaceutical pills using spectrophotometric method



8 Potentiometry, pH measurement, investigation of selectivity of ion selective electrodes, measurement of redox potential.



9 Measurement of conductivity in electrolytes



10 Investigation of kinetics of electrode processes, cyclic voltammetry, current - electrode potential curves, Cottrell form, Tafel’s

equation


equation


equation

11 Determination of solubility products using potentiometric measurements



12 Determination of dissociation coefficient of color indicators using spectrophotometric method.



13 Computer modeling chemical reactions



14 Determination of diffusion coefficients



Seminars

Exam topics/questions

There is no exam to be taken for passing the laboratory practice

Participants

(LEBGAAF.PTE), Kiss András (KIAIAET.PTE)


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OPA-KD1 COLLOIDICS 1

Course director: DR. BARNA SZILÁRD KOVÁCS, associate professor

Faculty of Natural Sciences - Department of General and Physical Chemistry

2 credit ▪ semester exam ▪ Basic subject ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 3 – 200 Prerequisites: OPA-AM1 completed

Topic

Learning about the types, structure, stability, chemical and physical-chemical properties and about laws of interaction of colloidal

systems.


-

Mid-term exams

Two written tests (after the 5th and 10th lessons) should be completed (min. 50%) during the semester.


-

Reading material



- Notes


D. J. Shaw: Introduction to Colloid and Surface Chemistry, 4th ed. (or later), Butterworth-Heinemann, Oxford 1992.,

D. F. Evans, H. Wennerström: The Colloidal Domain: Where Physics, Chemistry, Biology and Technology Meet, 2nd ed., Wiley-

VCH, New York 1999.

D. H. Everett: Basic Principles of Colloid Science, RSC, London 1988.

Lectures

1 The colloidal state

Dr. Kovács Barna Szilárd

2 Classification of colloidal systems


3 The structure of interfaces


4 Interfacial phenomena.


5 Surface tension.


6 Gas/liquid interface.


7 Interface of solution, phase boundary


8 Liquide/liquide interfaces


9 Solid/liquide interface


10 Capillary condensation. Wetting, wetting materials.


11 Adsorption phenomenon


12 Heat of adsorption, adsorption equations


13 Adsorption isotherms (Freundlich, Langmuir, Langmuir-Hückel, BET),



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14 Adsorption hysteresis


15 Electric double-layer, electrokinetic potential


16 Electrokinetic phenomena


17 Properties of dispersed systems: distribution, morfology, degree of dispersity


18 Stability of colloidal systems, parameters that affect the stability


19 Aerosols, foams


20 Emulsions, suspensions


21 Reology, properties and methodology.


22 Macromolecular colloids


23 Properties, examination methods of macromolecular colloids


24 Association colloids


25 Micelle formation


26 Parameters that affect the micelle formation


27 Liposomes


28 Langmuir Blodget films, LB technique.


Practices

Seminars


The colloidal state, classification of colloidal systems

The structure of interfaces, interfacial phenomena. Surface tension.

Gas/liquid interface. Interface of solution, phase boundary, liquide/liquide interfaces

Solid/liquide interface, capillary condensation. Wetting, wetting materials.

Adsorption phenomenon, heat of adsorption, adsorption equations, adsorption isotherms (Freundlich, Langmuir, Langmuir-Hückel,

BET), adsorption hysteresis.

Electric double-layer, electrokinetic potential, electrokinetic phenomena.

Properties of dispersed systems: distribution, morfology, degree of dispersity. Stability of colloidal systems, parameters that affect the

stability

Aerosols, foams, emulsions, suspensions.

Reology, properties and methodology.

Macromolecular colloids, properties, examination methods.

Association colloids, micelle formation, parameters that affect the micelle formation, liposomes, Langmuir Blodget films, LB technique.

Participants


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OPA-V1E ORGANIC CHEMISTRY 1 - THEORY

Course director: DR. TAMÁS KÁLAI, professor

Department of Organic and Pharmacological Chemistry

3 credit ▪ semester exam ▪ Basic subject ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 2 – 60

Prerequisites: OPA-L1E completed + OPA-AM1 completed + OPA-V1G parallel

Topic

This subject is a part of chemistry basics. Its aim to present the nomenclature, structure, physical and chemical properties, synthesis,

reaction mechanisms and application of organic compounds.


Maximum of 25 % absence allowed

Mid-term exams

Students can venture upon the accomplishment of written test two times.


Students have to contact the lecturer of the subject.

Reading material


John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th ed., Thomson Brooks, Belmont, 2007.


- Notes


T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

William H. Brown: Organic Chemistry, Saunders College Publishing, Fort Worth, 1995.

Lectures

1 The nature of chemical bonds; Hybridization; Polar covalent bonds, electronegativity; Acids and bases: Bronsted-Lowry and

Lewis definition

Dr. Kálai Tamás


Lewis definition

Dr. Kálai Tamás


Lewis definition

Dr. Kálai Tamás

4 The system of organic compounds, functional groups, reaction mechanisms.

Dr. Kálai Tamás

5 The system of organic compounds, functional groups, reaction mechanisms.

Dr. Kálai Tamás

6 Spectrometric structure identification of organic compounds.

Dr. Kálai Tamás

7 Isomerism and stereochemistry: constitutional isomerism, conformation, cis-trans isomerism, chirality, optical activity, specific

rotation, enantiomers and diastereomers, relative and absolute configuration.

Dr. Kálai Tamás



Dr. Kálai Tamás



Dr. Kálai Tamás

10 Alkanes and cycloalkanes; Orbital hybridization and the structure of alkanes; Nomenclature, physical and chemical properties,

conformation.

Dr. Kálai Tamás


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conformation.

Dr. Kálai Tamás


conformation.

Dr. Kálai Tamás

13 Unsaturated hydrocarbons: sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and

alkynes.

Dr. Kálai Tamás


alkynes.

Dr. Kálai Tamás


alkynes.

Dr. Kálai Tamás

16 Importance of unsaturated hydrocarbons in industry and biology: polymerization, isoprene, terpenes, steroids, carotenoids.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

19 Aromatic compounds: the structure of benzene, Hückel’s rule. Electrophilic aromatic substitution reactions. Substituent effects

in electrophilic aromatic substitution. Oxidation and reduction of aromatic compounds; Polycyclic compounds.

Dr. Kálai Tamás



Dr. Kálai Tamás



Dr. Kálai Tamás

22 Alkyl halides: the character of C-X bonds, synthesis and reactions of alkyl halides; Nuclephilic substitution reactions, SN1, SN2,

eliminations; Organic halides in the environment.

Dr. Kálai Tamás



Dr. Kálai Tamás



Dr. Kálai Tamás

25 Organometallic compounds: their importance in organic syntheses (Mg, Na, Li, Zn, Si, Cu, Cd compounds).

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

28 Alcohols: Structure, synthesis, physical and chemical properties, reactions; Their biological importance.

Dr. Pápayné Dr. Sár Cecília





31 Phenols and ethers: Structure, synthesis, physical and chemical properties, reactions; Their biological importance: polyphenols.






34 Sulfur containing compounds: Physical, chemical properties and synthesis of thiols and sulfides; Their importance in biological

processes (in amino acids, peptides, methylation in biology, AcCo-A, drugs).



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37 Overview of reaction mechanisms: radical, electrophilic and nucleophilic substitutions, electrophilic additions, eliminations.






40 Summary


41 Summary


42 Summary


Practices

Seminars


1.) Alkanes: Orbital hybridization and the structure of alkanes; Nomenclature, physical and chemical properties, combustion, free radical

chlorination, conformation, cycloalkanes, type of ring strains, demonstrate with examples.

2. Unsaturated hydrocarbons: sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and alkynes.

Electrophilic addition, Markovnikov’s rule, 1,2- and 1,4-addition, conjugated and cumulated dienes.

3. Importance of unsaturated hydrocarbons in industry and biology; polymerization, isoprene, terpenes, steroids, carotenoids, polymers,

rubber

4. Aromatic compounds: the structure of benzene, Hückels rule. Electrophilic aromatic substitution reactions. (Nitation, sulfonation,

bromination, Friedel-Crafts reactions), direction rules, classification of substituents, polyaromatics: examples, their chemical

reactions aromatic electophilic substitution, oxidation.

5. Alkyl halides: the character of C-X bonds, physical properties, reactivity of alkyl halides, synthesis of alkyl and aromatic halides, and

reactions of alkyl halides (substitution, elimination); Organic halides in the environment.

6. Organometallic compounds: their structure, their importance in organic syntheses (Mg, Na, Li, Si, Cu, Cd compounds).

7. Alcohols, phenols, ethers: Structure, physical and chemical properties, reactions; Their biological importance.

8. Stereochemistry: isomerism, absolute and relative configuration, chirality, racemates, diastereomers, polarimetry, resolution.

9. Sulfur containing compounds: Physical, chemical properties, importance in biological processes (in amino acids, peptides, methylation

in biology, AcCo-A, drugs, sulfonamides, penicillin, cefalosporin).

The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the

result different from “failed”).

Participants


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OPA-V1G ORGANIC CHEMISTRY 1 - PRACTICE



3 credit ▪ midsemester grade ▪ Basic subject ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 2 – 60 Prerequisites: OPA-L1E completed + OPA-AM1 completed

Topic

The aims of this course are to introduce students into several basic laboratory techniques and to demonstrate some characteristic reactions

of organic compounds with various functional groups.


During the semester students have to accomplish the preparative works and written tests. They have to document the experiments in their

exercise book.

Mid-term exams

The organic chemistry laboratory course will be graded (1-5), based on the two written tests on 5th and 11th week, first of all. The

evaluation can be modified by grades of semi-micro preparations, success of unknown identification as well as the outlook of the records

of exercise book.


Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.

Reading material



Kálai, T., Bognár, B. Organic Chemisry Laboratory Manual, Dept. of Org. and Med. Chem., Medical Faculty, University of Pécs,

2010.

- Notes


Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London,

1995.

Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd

ed., Wiley, New York, 1994.

Lectures

Practices

1 General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus.

Characteristic reactions of alkanes, alkenes and alkynes.





4 Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation,

determination of the melting point).





7 Basic laboratory operations II: Separation of dies with column chromatography; Identification of 1st unknown compound.

Characteristic tube reactions of aromatic hydrocarbons.





10 Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the

boiling point); Characteristic tube reactions of alkyl halides.




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13 1st written test; Synthesis of p-bromo-acetanilide and p-nitro-acetanilide.



16 Characteristic tube reactions of alcohols, phenols and ethers.



19 Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;



22 Basic laboratory operations IV: Continuous extraction, thin layer chromatography, measurement of optical activity, infrared

spectroscopy. Isolation of piperine.





25 Preparation of 4-amino-benzenesulfonamide and nitrobenzene.






31 2nd written test. Characteristic reactions of amines.



34 Preparation of anthranilic acid; Identification of 3rd unknown compound.



37 Preparation of 2-iodobenzoic acid;



40 Evaluation.

41 Evaluation.

42 Evaluation.

Seminars


The written tests will contain the matter of practice.

Participants

Dr. Bognár Balázs (BOBGAAT.PTE), Dr. Kálai Tamás (KATFABP.PTE), Dr. Pápayné Dr. Sár Cecília (PASFADP.PTE)


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OPO-AI2 HUMAN ANATOMY, HISTOLOGY AND EMBRIOLOGY 2

Course director: DR. ANDREA PETHŐ-LUBICS, associate professor

Department of Anatomy

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 1 – 100 Prerequisites: OPO-AI1 completed

Topic

The subject describes the macroscopic and microscopic structure of the human body. Students will learn in lectures (1x45 min/week)

and seminars (1x90 min. every even week) how the organs are built up. In the second part of the 2-Semester study macroscopic and

microscopic anatomy of the reproductive system, endocrine organs and the nervous system are represented with the aid of formalin-fixed

cadavers, organ preparations and plastic models. General embryology includes the most important steps of the human development.



Mid-term exams


The seminars can be made up with the attendance in the seminar of another pharmacy group of the same week (only twice in a semester

possible)

Reading material


http://an-server.pote.hu



- Notes




Lectures

1 Male genital organs

Dr. Kiss Péter

2 Female genital organs 1. Ovarium, tuba uterina, uterus. The ovulation and the menstruation cyclus.

Dr. Tamás Andrea

3 Female genital organs 2. Pregnancy, placenta. Vagina, external genital organs.

Dr. Tamás Andrea

4 The main parts of the human development. Main steps during the zygote and the embryonic period.

Dr. Kiss Péter

5 Parts of the nervous system. Peripheral nervous system.

Dr. Tóth Pál

6 Macroscopic structure of the central nervous system. (Main parts, ventricles, meninges, blood supply)

Dr. Tóth Pál

7 Nervous tissue

Dr. Tóth Pál

8 Sensory pathways

Dr. Gaszner Balázs

9 Motor pathways

Dr. Gaszner Balázs

10 The endocrine glands

Opper Balázs

11 The autonomic nervous system

Dr. Nagy András Dávid

12 Structure of the visual system

Dr. Horváth-Opper Gabriella

http://an-server.pote.hu/





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13 Structure of the auditory and the vestibular system

Dr. Horváth-Opper Gabriella

14 Fetal period. Signs of the maturity od the newborn baby. Malformations and their causes.

Dr. Farkas Boglárka Anett

Practices

Seminars

1 Anatomy: organs of the lesser pelvis

2 Anatomy: organs of the lesser pelvis

3 Histology: ovary, uterus, vagina, testis, prostate gland

4 Histology: ovary, uterus, vagina, testis, prostate gland

5 Anatomy: spinal cord, meninges, cranial nerves

6 Anatomy: spinal cord, meninges, cranial nerves

7 Anatomy: macroscopic structure of the brain

8 Anatomy: macroscopic structure of the brain

9 Histology: peripheral nerve, spinal cord, cerebellum, neocortex

10 Histology: peripheral nerve, spinal cord, cerebellum, neocortex

11 Histology: pituitary gland, thyroid gland, suprarenal gland

12 Histology: pituitary gland, thyroid gland, suprarenal gland

13 Anatomy: eye, inner and middle ear with models

14 Anatomy: eye, inner and middle ear with models


Written test (A chance) at the beginning of the exam period. B, C and D chances are oral exams.


Participants

Dr. Jüngling Adél (JUARAAO.PTE), Gaszner Tamás (GATRAAO.PTE), Kovács László Ákos (KOLQAAO.PTE), Kovács László Ákos

(KOLQAAO.PTE)



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OPO-G1E PHARMACOBOTANY 1 - THEORY

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy



Course headcount limitations (min.-max.): 3 – 80 Prerequisites: OPR-LAT completed + OPO-G1G parallel

Topic

Pharmacobotany covers all pharmaceutical aspects of botany, including cytology, histology, morphology and taxonomy of plants. Plant

systematics discusses the geographical origin of plant species, the possibilities of their cultivation and protection. A special emphasis is

laid on chemotaxonomic aspects, since the medicinal effect of a plant is often related to its taxonomic classification and chemical

characteristics. Practical instruction focuses on the knowledge of medicinal plants, including the confident use of plant identification

keys. Based on their knowledge of histology and morphology, students are required to apply proper anatomical terms, and finally identify

plant species (taxa). The thorough knowledge of both general and specific pharmacobotany is a prerequisite of studying pharmacognosy.



Mid-term exams

Students have to pass (min. 60%)two written exams based on lecture materials. The exams will be held on the 7th and 13th week of the

semester.

For each test, maximum two other chances (B and C chance) will be offered for students who do not pass the exam on the first occassion

(A chance).


Reading material


Á. Farkas: Pharmacobotany 1, University of Pécs, Institute of Pharmacognosy, Pécs, 2010


Farkas Á., Papp N., Bencsik T., Horváth Gy.: Digital Herbarium and Drug Atlas, electronic learning material, 2014 TÁMOP-

4.1.2.A/1-11/1-2011-0016

Lecture materials (PowerPoint slides) will be available in Neptun.

- Notes


D.F. Cutler, T. Botha, D.W. Stevenson: Plant Anatomy. An Applied Approach, Wiley-Blackwell, 2008

R.F. Evert, S.E. Eichhorn: Esaus Plant Anatomy: Meristems, Cells and Tissues of the Plant Body: Their Structure, Function and

Development, 3rd edition, Wiley

A. Fahn: Plant Anatomy, 4th edition

Lectures

1 Structure of the plant cell. Plastids and inclusions.

Dr. Farkas Ágnes

2 Structure of the cell wall.

Dr. Farkas Ágnes

3 Plant tissues I. Meristematic tissues.

Dr. Farkas Ágnes

4 Plant tissues II. Epidermal tissue; stomata, trichomes, secondary epidermis.

Dr. Farkas Ágnes

5 Plant tissues III. Vascular tissues; vascular bundle types.

Dr. Farkas Ágnes

6 Plant tissues IV. Ground tissues: parenchyma, collenchyma, sclerenchyma, secretory tissues.

Dr. Farkas Ágnes

7 1st written exam

Dr. Farkas Ágnes

8 Root morphology. Modified roots. Root anatomy

Dr. Farkas Ágnes


15

9 Shoot morphology and anatomy. Shoot types.

Dr. Farkas Ágnes

10 Leaf morphology and anatomy. Leaf arrangement (phyllotaxis). Leaf venation.

Dr. Farkas Ágnes

11 Flower morphology. Inflorescence types.

Dr. Farkas Ágnes

12 Fertilisation, embryogenesis, ovule and seed. Fruit types.

Dr. Farkas Ágnes

13 2nd written exam

Dr. Farkas Ágnes

14 Taxonomic categories, chemotaxonomic relations, rules of nomenclature.

Dr. Farkas Ágnes

Practices

Seminars




The grades of the 2 written lecture tests serve as the basis of the final course grade.

Exam topics:

1. Structure of the plant cell.

2. Plastids and inclusions.

3. Structure of the cell wall.

4. Meristematic tissues.

5. Epidermal tissue; stomata.

6. Trichomes, secondary epidermis.

7. Vascular tissues

8. Vascular bundle types.

9. Ground tissues: parenchyma, collenchyma.

10. Ground tissues: sclerenchyma, secretory tissues.

11. Root morphology and anatomy

12. Modified roots.

13. Shoot morphology and anatomy.

14. Shoot types.

15. Leaf morphology and anatomy.

16. Leaf arrangement (phyllotaxis). Leaf venation.

17. Flower morphology.

18. Inflorescence types.

19. Fertilisation, embryogenesis, ovule and seed.

20. Fruit types: dehiscent fruits.

21. Fruit types: indehiscent fruits.

22. Fruit types: compound and aggregate fruits.

Participants


16

OPO-G1G PHARMACOBOTANY 1 - PRACTICE



1 credit ▪ midsemester grade ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 3 – 80 Prerequisites: OPR-LAT completed

Topic


systematics discusses the geographical origin of plant species, the possibilities of their cultivation and protection. A special emphasis is

laid on chemotaxonomic aspects, since the medicinal effect of a plant is often related to its taxonomic classification and chemical

characteristics. Practical instruction focuses on the knowledge of medicinal plants, including the confident use of plant identification

keys. Based on their knowledge of histology and morphology students are required to apply proper anatomical terms, and finally identify




Mid-term exams

Students have to pass (min. 60%)two written exams based on the practice materials. The exams will be held on the 7th and 13th week of

the semester. For each test, maximum two other chances (B and C chance) will be offered for students who do not pass the exam on the

first occassion (A chance).

In the practice, students have to take notes and prepare drawings based on microscopic examinations. Students have to show their lab

notebook to the practice leader, who acknowledges fulfillment of the practice by his/her signature.

The grades of the 2 written practical tests and the lab notebook serve as the basis of the practical grade.


Participation is compulsory in lab practices; up to 2 absences are allowed. Missed practices can be made up either by joining the other

groups or taking extra time at the following lab practice. In all cases, students must make arrangements with their lab instructors in

advance.

Reading material


N. Papp: Pharmacobotany Practices, University of Pécs, Institute of Pharmacognosy, Pécs, 2011



4.1.2.A/1-11/1-2011-0016

- Notes

Á. Farkas: Pharmacobotany 1, University of Pécs, Institute of Pharmacognosy, Pécs, 2010


D.F. Cutler, T. Botha, D.W. Stevenson: Plant Anatomy. An Applied Approach, Wiley-Blackwell, 2008

Lectures

Practices

1 Microscopic techniques and preparations (leaf clearing, cross sections, epidermal tissues). Plastids of the plant cell. Inclusions

and crystals.

2 Chemical substances of the cell wall (cellulose, lignin). Mucilage content of the cell wall and the cytoplasm. Investigation of

vacuolar content (inulin, alkaloids, tannins, anthocyanins).

3 The root and shoot tip; meristematic tissues.

4 Leaf epidermis; cross sections and cleared preparations.

5 Microscopic study of stem cross sections: vascular tissues and mechanical tissues.

6 Ground tissues. Plant secretory systems (schizogenous, lysigenous cavities, laticifers, glandular trichomes, glandular scales,

nectaries).

7 Perianth, androecium, gynoecium. Tissue structure of the fruit and seed.

8 Morphological analysis of the root and its modifications.

9 Shoot system types, shoot modifications.

10 Leaf types, leaf arrangement, parts of the leaf. Shape, margin and venation of leaves, leaf modifications.


17

11 Morphological analysis of the flower: perianth, androecium, gynoecium. Floral formula, floral diagram.

12 Morphological investigation of inflorescences.

13 Fruit morphology: Dry dehiscent and indehiscent fruits.

14 Fruit morphology: Fleshy fruits, compound fruits and false fruits.

Seminars


Participants

Dr. Papp Nóra (PANAAA.T.JPTE)


18

OPO-H1E HUMAN PHYSIOLOGY 1 - THEORY

Course director: DR. ZOLTÁN KARÁDI, professor

Institute of Physiology




Prerequisites: OPO-GB2 completed + OPO-AI2 parallel + OPO-H1G parallel

Topic

The most important mission of the Physiology Course in medical education is to familiarize students with the attributes of healthy

functions of the living organism.

While acquiring knowledge about the most important functional characteristics of the human body the students can rely on their prior

studies in biology, biophysics, chemistry-biochemistry and anatomy.

During the semester we introduce the most important elements of functioning of the organs and organ systems, as well as their cooperation

also required to adapting to the environment, and the factors affecting these processes.

Special emphasis is placed on the neural and humoral regulatory processes of these life-functions, which are vital to maintain and preserve

the homeostasis of the organism.

With the transfer of all this knowledge we would like to mould a holistic attitude and thinking of students, which will enable them to

better understand the functions of the now healthy, however, later dysfunctional human organism.



Mid-term exams

Written test on the 11th week Friday at 16:00.


The missed lab practice is advised to be covered by joining another group while the same topic is on schedule.

Reading material


J.E. Hall: Guyton and Hall Textbook of Medical Physiology, 12th edition, 2013


Figures of the lectures given are available on the homepage of Institute of Physiology and on the Neptun Meet Street.

Important messages on new information will be announced at the lectures and will be sent to you by course mails.

Please always find the current updated information and study materials on the homepage of the Institute of Physiology

(physiology.aok.pte.hu).

- Notes

Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practices 1, internet study material, printable notebook, 2014

Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practice Worksheets 1, internet study material, printable notebook,

2014


L.S. Costanzo: Physiology, 5th edition, 2014

W.F. Ganong: Review of Medical Physiology, 2012, Appleton and Lange, Lange Medical Publications

Fonyó: Principles of Medical Physiology, Medicina Publishing, 2002

J.B. West (ed.): Best and Taylor’s Physiological Basis of Medical Practice, Williams and Wilkins, 1998

Lectures

1 Introduction. Principles of the homeostatic regulations.

Dr. Környei József László

2 Cellular transport processes.

Humoral control mechanisms.


3 Basics of electrophysiology. Equilibrium potential, electrotonic potentials and action potential. The autonomic nervous system 1.

Dr. Buzás Péter

4 Fluid distribution in the body. The blood.

Dr. Zelena Dóra


19

5 Anorganic and organic blood constituents.

Kertes Erika

6 Structure and metabolism of hemoglobin.

Metabolism of iron.

Dr. Szabó István

7 The physiological role of leukocytes.

Dr. Szabó István

8 Mechanism of blood coagulation.

Dr. Szabó István

9 Blood group systems.

Dr. Szabó István

10 The cardiac cycle.

Generators and conductors of impulses in the heart.


11 Electrocardiogram.

12 Distribution of blood volume, pressure flow and resistance in the heart. Heart sounds.


13 Cardiac output and cardiac work.


14 Distribution of blood volume, pressure flow and resistance. Blood pressure. Arterial pulse

Dr. Ábrahám István Miklós

15 Circulation through the capillaries. Circulation in the veins. The formation, pressure and flow of lymph.

Kóbor Péter

16 Pulmonary circulation, cerebral circulation. Circulation of the skin and skeletal muscle. Splanchnic circulation. Coronary

circulation.

Kóbor Péter

17 Neural and humoral regulatory mechanisms of the cardiovascular system.

Homeostatic regulation of the cardiovascular system.

Dr. László Kristóf

18 Mechanics of respiration Intrathoracic pressure. Compliance. Respiratory volumes. Dead spaces.


19 Gaseous exchange in the lungs and tissues. Chemical control of respiration. O2 and CO2 transport mechanism and pH regulation.


20 Neural regulatory mechanisms of respiration. Mechanisms of acclimatization.

Petykó Zoltán

21 The gastrointestinal tract. Function and control of salivary secretion. The stomach. Gastric secretion.

Dr. Buzásné Dr. Telkes Ildikó

22 Duodenal processes. Biliary secretion. Secretion and absorption in the small intestine.


23 Liver functions.

Péczely László Zoltán

24 Secretion and absorption in the large intestine. Formation of the feces. Digestion and absorption of different nutrients. Vitamins.

Dr. Ollmann Tamás

25 Humoral and neural control of the gastrointestinal system.


26 Dynamics of glomerular filtration. Plasma clearance. Renal blood flow. Extraction ratio. Filtration fraction.


27 Renal circulation. The renin-angiotensin system.


28 Tubular processes. Concentrating and diluting mechanisms. Osmoregulation.


29 Fluid volume regulation of the body. The mechanisms of urination.


30 Acid-base regulation.


31 Energy balance. Metabolism. Nutrition. Body mass regulation.



20

32 Body temperature of man. Hyperthermia, fever.

Kertes Erika

33 Peripheral control of body temperature.

Central control mechanisms of body temperature.

Kertes Erika

34 The hypothalamo-hypophyseal system.


35 Anterior pituitary hormones.


36 Cellular mechanisms of hormone action.


37 Hormonal regulation of female sexual functions.

Dr. Lengyel Ferenc

38 Pregnancy. Lactation.

Dr. Lengyel Ferenc

39 Hormonal regulation of male sexual function.

Erection, ejaculation, coitus. Puberty. Climacteric.

Kóbor Péter

40 Humoral and central neural control of sexual behavior.

Kóbor Péter

41 Functions of posterior lobe of pituitary gland.


42 Thyroid physiology.

Kovács Anita

Practices

Seminars




Topics of questions for the theoretical examination

1. Describe the body fluid compartments and explain the methods used for measurement of body fluid volumes

2. Describe the major plasma proteins and the other non-electrolytic constituents of blood and explain their function in the body

3. Describe the intra- and extracellular ionic components and explain their physiological functions

4. The structure, function and origin of erythrocytes

5. Characterize the various leukocytes indicating their origins and functions

6. Origin and function of blood platelets

7. The basic structure and metabolism of haemoglobin and the metabolism of iron

8. Describe the two pathways involved in the initiation of blood coagulation

9. Specific mechanism of clot formation

10. Describe the mechanism of fibrinolysis. Explain the significance of anticlotting mechanism

11. Regulation of H+ ion concentration in the blood

12. A-B-0 blood groups. The Rh blood types

13. The role of leukocytes in the defence mechanism

14. Mechanical activity of the heart and the three-component model of heart muscle. Calcium ion movements within the cardiac muscle cell

15. Generators and conductors of impulses in the heart. Refractory periods

16. The sequence of events in the cardiac cycle

17. The human electrocardiogram (ECG). Electrocardiography: bipolar and unipolar leads

18. The heart sounds. Phonocardiography (PCG)

19. Cardiac output: measurement, normal standards and physiological variations

20. Metabolism and energetics of cardiac muscle

21. Ventricular wall tension and the Laplace relationship

22. The heart-lung preparation (Starling`s laws)

23. Arterial blood pressure: determinants of normal arterial blood pressure

24. The arterial and the venous pulse. Basic principles of hemodynamics.

25. Circulation through the capillaries

26. The properties, production and the movement of lymph

27. Circulation in the vein. Effect of gravity on circulation


21

28. The pulmonary circulation. Control of lung vessels

29. The coronary circulation

30. Cerebral circulation. The concept of blood-brain barrier.

31. Splanchnic circulation

32. Skeletal muscle circulation. Cutaneous circulation

33. Nervous control of the heart

34. Control mechanisms of the circulatory system: general considerations

35. Local control of the vascular smooth muscle

36. Autoregulation of blood flow in tissues and organs

37. The function and importance of baroreceptors in the regulation of circulation

38. Reflex control mechanisms of circulation

39. Mechanisms of vasoconstriction and vasodilatation

40. Mechanics of respiration (functions of respiratory muscles, compliance, intrathoracic pressures, respiratory volumes)

41. Alveolar air, alveolar ventilation, dead spaces. Function of the respiratory passageways

42. Gaseous exchange in the lungs and tissues

43. O2 and CO2 transport in the body

44. Peripheral and central regulatory mechanisms of respiration. Respiratory reflexes

45. Chemical control of respiration. Acidosis, alkalosis

46. Different types of hypoxia. Oxygen treatment. Mechanisms of acclimatisation. Nitrogen narcosis. Decompression sickness

47. Describe the origin, composition, function and control of salivary secretion

48. Describe the origin, nature and function of gastric secretion indicating the mechanisms of regulation

49. Mechanism and regulation of gastrointestinal movements

50. Identify the pancreatic secretions, their components, their action and the substrates on which they act. Control mechanism of

pancreatic secretion

51. Describe the basic ingredients and functions of the bile indicating the origin and fate of the components and the factors controlling

bile secretions and gall bladder functions

52. Identify the components and functions of the intestinal system

53. Describe how carbohydrate is digested and absorbed indicating the enzymes involved

54. Describe how fat is digested and absorbed indicating the enzymes and secretions involved

55. Describe how protein is digested and absorbed indicating the enzymes and secretions involved

56. Dynamics of glomerular filtration. Glomerular filtration rate. Plasma clearance

57. Renal blood flow. Clearance of PAH. Extraction ratio. Filtration fraction

58. Regulation of renal blood flow and pressure. Renin-angiotensin system

59. Reabsorption and secretion of different substances in the renal tubule. Methods for their investigation

60. Concentrating and diluting mechanisms of the kidney

61. Fluid volume regulation of the body

62. Regulation of concentrations of ions in the extracellular fluid. Regulation of osmolality of body fluids

63. Basal metabolic rate. Describe factors influencing the basal metabolism

64. Define metabolic rate explaining those factors influencing the total expenditure of energy by the body

65. Describe the necessary elements of normal diet

66. The normal body temperature and its physiological variations. Hyperthermia, fever, hypothermia

67. Chemical regulation of body temperature, changes of regulation at low and high environmental temperature

68. Physical regulation of body temperature, changes of regulation at low and high environmental temperature

69. Central regulatory mechanisms of heat production and heat loss

70. Mechanisms of hormone action (receptors, intracellular mediators, cAMP, Ca2+ and diacylglycerol, protein kinases)

71. Mechanism of hormonal regulation. Negative and positive feedback controls in the endocrine system

72. The anterior pituitary hormones. Regulation of pituitary hormone secretions. Pituitary dysfunction

73. Function of growth hormone during development and after adolescence

74. Abnormalities of thyroid secretion. Goitrogens

75. Function of the thyroid gland. Iodine metabolism in the body

76. Hormonal changes during menstrual cycle

77. Hormonal changes during pregnancy. Role of placenta in pregnancy. Foeto-placental unit

78. Hormones of lactation

79. Mechanism of erection and ejaculation. The sexual act (coitus)

80. The function of testis, epididymis, seminal vesicle and prostate

81. Regulation of the sexual behaviour. Maternal behaviour

82. Physiological changes at puberty and climacteric

83. Vasopressin and oxytocin. Function of ANH (atrionatriuretic hormone)

84. The effects of prostaglandins


22

Questions for the student lab report:

1. Hematocrit

2. Red blood cell counting

3. White blood cell counting

4. Differential leukocyte count

5. Determination of osmotic resistance.

6. Determination of hemoglobin concentration

7. MCV, MCH, MCHC values

8. Prothrombin time

9. Blood group determination (AB0 and Rh typing)

10. Examination of hemoglobin spectra

11. How to use work stations for electrophysiological registrations

12. Recording of heart beats of the frog „in situ”

13. Electric stimulation of heart (demonstr. of extrasystole)

14. Effect of thermal stimulations of frog’s heart.

15. Ligatures of Stannius

16. Investigation of Bowditch’s „All or nothing” law

17. Investigation of summation

18. Electrocardiography (ECG)

19. Examination of the arterial pulse

20. Measurement of blood pressure in human

21. Isolated frog’s heart preparing by Straub cannulla

22. Effect of acethylcholin on isolated frog’s heart

23. Effect of adrenalin on isolated frog’s heart

24. Effect of ions on the isolated heart

25. Direct measurement of blood pressure in cat

26. The circulation through capillaries of frog’s tongue.

27. Pulse wave registration.

28. Spirometry, dynamic parameters of respiration

29. Volumes and capacities of the lungs.

30. Measurement of maximal respiratory pressures (The experiments of Müller and Valsalva)

31. Demonstration of basic respiratory movements and pressure/volume changes (Donders model)

32. Gastric juice: Determination of BAO, MAO, PAO

33. Bile: detection of bile pigments

34. Feces: Detection of blood (Guajac-, benzidin-, Hematest)

35. Measurement of the actual metabolic rate in human

36. Measurement of the oxigen consumption in rat.

37. Specific gravity of urine.

38. Examination of the urine sediment

39. Urine examination with reagent strip methodology

40. Examination of pathological urine components with tests in tubes: protein, glucose, keton bodies, blood, ubg, bilirubin, pus detections

Study material for the semester exam is the sum total of information covered in the obligatory textbook, on the homepage of the Institute,

as well as knowledge given at the lectures and lab practices.

Participants


23

OPO-H1G HUMAN PHYSIOLOGY 1 - PRACTICE



2 credit ▪ midsemester grade ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPO-GB2 completed + OPO-AI2 parallel

Topic













Mid-term exams




Reading material








- Notes



2014






Lectures

Practices

1 Getting acquainted with the laboratory. General information, schedules. Personal- and equipment safety rules. Animal care

regulations.

2 Getting acquainted with the laboratory. General information, schedules. Personal- and equipment safety rules. Animal care

regulations.

3 Blood I.

4 Blood I.

5 Blood II.

6 Blood II.


24

7 Blood III.

8 Blood III.

9 Seminar: Blood (Discussion of the topics covered by the lectures and student labs)

10 Test on the chapter

11 The heart and circulation I.

12 The heart and circulation I.

13 The heart and circulation II.

14 The heart and circulation II.

15 The heart and circulation III.

16 The heart and circulation III.

17 The heart and circulation IV.

18 The heart and circulation IV.

19 Seminar: The heart and circulation

20 Test on the chapter

21 Respiration

22 Respiration

23 Gastrointestinal tract

24 Gastrointestinal tract

25 Examination of the urine

26 Examination of the urine

27 Measurement of the actual metabolic rate in human

28 Measurement of the actual metabolic rate in human

Seminars
















14. Mechanical activity of the heart and the three-component model of heart muscle. Calcium ion movements within the cardiac muscle

cell








22. The heart-lung preparation (Starling`s laws)








30. Cerebral circulation. The concept of blood-brain barrier.




25
























































26


1. Hematocrit

2. Red blood cell counting

3. White blood cell counting

4. Differential leukocyte count

5. Determination of osmotic resistance.

6. Determination of hemoglobin concentration

7. MCV, MCH, MCHC values

8. Prothrombin time

9. Blood group determination (AB0 and Rh typing)

10. Examination of hemoglobin spectra

11. How to use work stations for electrophysiological registrations

12. Recording of heart beats of the frog „in situ”

13. Electric stimulation of heart (demonstr. of extrasystole)

14. Effect of thermal stimulations of frog’s heart.

15. Ligatures of Stannius

16. Investigation of Bowditch’s „All or nothing” law

17. Investigation of summation

18. Electrocardiography (ECG)

19. Examination of the arterial pulse

20. Measurement of blood pressure in human

21. Isolated frog’s heart preparing by Straub cannulla

22. Effect of acethylcholin on isolated frog’s heart

23. Effect of adrenalin on isolated frog’s heart

24. Effect of ions on the isolated heart

25. Direct measurement of blood pressure in cat

26. The circulation through capillaries of frog’s tongue.

27. Pulse wave registration.

28. Spirometry, dynamic parameters of respiration

29. Volumes and capacities of the lungs.

30. Measurement of maximal respiratory pressures (The experiments of Müller and Valsalva)

31. Demonstration of basic respiratory movements and pressure/volume changes (Donders model)

32. Gastric juice: Determination of BAO, MAO, PAO

33. Bile: detection of bile pigments

34. Feces: Detection of blood (Guajac-, benzidin-, Hematest)

35. Measurement of the actual metabolic rate in human

36. Measurement of the oxigen consumption in rat.

37. Specific gravity of urine.

38. Examination of the urine sediment

39. Urine examination with reagent strip methodology

40. Examination of pathological urine components with tests in tubes: protein, glucose, keton bodies, blood, ubg, bilirubin, pus detections

Study material for the semester exam is the sum total of information covered in the obligatory textbook, on the homepage of the Institute,

as well as knowledge given at the lectures and lab practices.

Participants

Kovács Anita (KOAMAET.PTE), Tóth Attila (TOABAB.T.JPTE)


27

ATT3 PHYSICAL EDUCATION 3

Course director: TAMÁS TÉCZELY, physical education teacher

UP MS Sports Facilities

0 credit ▪ signature ▪ Criterion requirement subject ▪ both semesters semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 2 – 50 Prerequisites: ATT2 completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to

deepen the knowledge in the field of healthy lifestyle.

Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and

how to prevent the body from injuries.


Active participation at least 20 practical lessons provided by the Institute of Human Movement Sciences or regular participation of the

trainings of the Medikus Sport Club or PEAC.

Mid-term exams

-


We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the

end of the teaching weeks with agreement of the PE Teacher.

Reading material



Not available.

- Notes

Recommended literature Lectures Practices

1-28 For the list of actual courses please turn to the end of this document

Seminars


Participants

Farkas György (FAGMAAO.PTE), Lipcsik Zoltán (LIZIAAT.PTE), Németh Attila Miklós (NEAGAET.PTE), Téczely Tamás

(PETLAAT.PTE)


28

OPA-G1B PHARMACEUTICAL BIOCHEMISTRY 1

Course director: DR. KATALIN SIPOS, associate professor

Department of Forensic Medicine

3 credit ▪ semester exam ▪ Basic subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPA-L1E completed + OPA-AM1 completed

Topic

The two-semester biochemistry course provides the essential fundamental biochemistry knowledge for the pharmaceutical students. This

course deals with the metabolic pathways of the living cell: the reactions, steps and regulation of these pathways. In the first semester

students will be introduced to the life of the basic synthetic and anabolic biochemical pathways and they will study how energy is

produced in the cell. We will pay special attention to enzymes: their features, regulations, roles in the drug metabolism and action.



Mid-term exams

There are two mid-term exams. The results of them is included in the result of the exam.


According to personal agreement

Reading material



The materials of the lectures and seminars will appear on Neptune.

- Notes

The e-notes of Biochemistry will appear on Neptune.


Ch. P. Woodbury: Biochemistry for the Pharmaceutical Sciences

Raymond S. Ochs: Biochemistry

Thomas M. Devlin: Textbook of Biochemistry with Clinical Correlations

Lectures

1 Introduction

Dr. Sipos Katalin

2 Thermodynamics, biochemical reactions

Dr. Sipos Katalin

3 Biomembranes. Transport processes I

Dr. Sipos Katalin

4 Transport processes II

Dr. Sipos Katalin

5 Enzymes: characteristics, types, catalytic activities

Dr. Sipos Katalin

6 Proteases

Dr. Pandur Edina

7 Basic regulatory mechanisms in metabolism

Dr. Sipos Katalin

8 Glycolysis

Dr. Farkas Viktória

9 Gluconeogenesis


10 Glycogen metabolism


11 Cori cycle



29

12 Pentose phosphate pathway


13 Metabolism of complex carbohydrates

Dr. Sipos Katalin

14 Pyruvate dehydrogenase complex


15 Citric acid cycle


16 Mitochondrial transport processes


17 Terminal oxidation, ATP synthesis I


18 Terminal oxidation, ATP synthesis II


19 Degradation of lipids

Dr. Sipos Katalin

20 Ketone bodies


21 Biosynthesis of fatty acids


22 Biosynthesis of complex lipids

Dr. Sipos Katalin

23 Cholesterol metabolism I


24 Cholesterol metabolism II


25 Characterization of amino acids

Pap Ramóna

26 Nucleic acids: building blocks, structures

Varga Edit

27 Preparation for exam

Dr. Sipos Katalin


Dr. Sipos Katalin

Practices

Seminars

1 Macromolecules in biochemistry

2 Nutrition and vitamins in biochemistry

3 Carbohydrates: biochemical characterization. Carbohydrates in the extracellular space

4 Clinical importance of carbohydrates

5 Regulation of enzymes

6 Enzymekinetics. Inhibition of enzymes

7 Structure, folding and degradation of proteins

8 Lipids: phospholipids, sphingolipids, cholesterol, fatty acids

9 Clinical importance of lipids

10 Clinical consequences of terminal oxidation.

11 Carbohydrate metabolism

12 Lipid metabolism

13 Enzyme inhibiting drugs



There are no given exam questions. The topics of the exam will be the materials of lectures and seminars.

Participants

Dr. Farkas Viktória (FAVSAAP.PTE), Dr. Sipos Katalin (SIKMAAO.PTE), Pap Ramóna (PARTAAT.PTE), Varga Edit

(VAEQABT.PTE)


30

OPA-M1E INSTRUMENTAL ANALYSIS - THEORY

Course director: DR. FERENC KILÁR, professor

Institute of Bioanalysis

2 credit ▪ semester exam ▪ Basic subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 200 Prerequisites: OPA-L2E completed + OPA-M1G parallel

Topic

The theory of instrumental analysis. Basic and modern instrumental techniques for pharmaceutical analysis.



Mid-term exams

Two written tests (7th and 13th weeks) during the semester. No opportunity for retake of the written tests.


No opportunity for retake of the lectures.

Reading material



Material can be downloaded from the website of the Institute of Bioanalysis under the

Educational materials link: http://aok.pte.hu/en/egyseg/oktatas/160 (the username and password

are provided in the lectures).

- Notes


D.A. Skoog, F.J. Holler, S.R. Crouch: Principles of Instrumental Analysis, 6th edition, Thomson,

2007

D.G. Watson: Pharmaceutical Analysis, Elsevier

Lectures

1 Basis of creating instrumental signals

Dr. Kilár Ferenc

2 Errors in instrumental analysis, signal collection

Dr. Kilár Ferenc

3 Basic chemometry

Dr. Kilár Ferenc

4 Electroanalysis (potentiometry, conductometry, voltammetry)

Dr. Kilár Ferenc

5 Spectrophotometry

Dr. Kilár Ferenc

6 Spectrophotometry

Dr. Kilár Ferenc

7 Infrared spectroscopy, fluorescence spectroscopy

Dr. Kilár Ferenc

8 Infrared spectroscopy, fluorescence spectroscopy

Dr. Kilár Ferenc

9 Liquid chromatography, HPLC

Dr. Kilár Ferenc

10 Liquid chromatography, HPLC

Dr. Felinger Attila

11 Gas-chromatography

Dr. Kilár Ferenc


Dr. Poór Viktória

http://aok.pte.hu/en/egyseg/oktatas/160


31

13 Electrokinetic methods, electrophoresis

Dr. Kilár Ferenc

14 Electrokinetic methods, electrophoresis

Páger Csilla

15 Atomic absorption spectrometry

Dr. Kilár Ferenc


Páger Csilla

17 Nuclear magnetic resonance spectrometry

Dr. Berente Zoltán

18 Nuclear magnetic resonance spectrometry

Dr. Kilár Ferenc

19 Electron paramagnetic resonance spectrometry

Dr. Kilár Ferenc

20 Electron paramagnetic resonance spectrometry

!Dr. Dergez Tímea

21 Mass spectrometry

Dr. Kilár Ferenc


Dr. Kilár Ferenc

23 Analytical ultracentrifugation

Dr. Kilár Ferenc

24 Analytical ultracentrifugation

Dr. Kilár Ferenc

25 Mössbauer spectroscopy

Dr. Kilár Ferenc

26 ORD, CD, polarimetry

Dr. Kilár Ferenc

27 Thermal analysis

Dr. Kilár Ferenc

28 Thermal analysis

Dr. Kilár Ferenc

Practices

Seminars


Exam topics can be found in the website of the Institute of Bioanalysis under the

Education link: http://aok.pte.hu/en/egyseg/oktatas/160

Examcourse cannot be taken if the practice has not been accepted with „satisfactory” grade. The criterion of admission to the exam is the

successful completion of the practice carried out in paralell (midsemester grade with the result different from “failed”).

Participants



32

OPA-M1G INSTRUMENTAL ANALYSIS - PRACTICE

Course director: DR. FERENC KILÁR, professor

Institute of Bioanalysis

3 credit ▪ midsemester grade ▪ Basic subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 200 Prerequisites: OPA-L2E completed

Topic

Instrumental analysis practices, which are coupled to the theory of instrumental analysis.

Collection and evaluation of data, and preparation of report using several, major instrumental analytical techniques.



Mid-term exams

Each practice is preceded with a short written test, and the students should prepare a report of the measurements and the evaluation. A

final grade will be given for the practices, if 75 % of the practices are completed successfully (minimum „satisfactory” grade).


Maximum two absences are allowed, and one absence can be retaken in selected practices.

Reading material



Material can be downloaded from the website of the Institute of Bioanalysis under the

Educational materials link: http://aok.pte.hu/en/egyseg/oktatas/160 (the username and password

are provided in the lectures).

- Notes

Instrumental Analysis. Laboratory Practice. DOI: 10.15170/TTK.2014.00001 (dowloadable using the DOI number).


D.A. Skoog, F.J. Holler, S.R. Crouch: Principles of Instrumental Analysis, 6th edition, Thomson,

2007

D.G. Watson: Pharmaceutical Analysis, Elsevier

Lectures

Practices

1 Introduction to the laboratory practices.



4 Potentiometry

5 Potentiometry

6 Potentiometry

7 Conductometry

8 Conductometry

9 Conductometry

10 Spectrophotometry











33

19 HPLC

20 HPLC

21 HPLC

22 Capillary electrophoresis



25 Infrared spectrometry



28 NMR

29 NMR

30 NMR







37 Coupled separation techniques



40 Retake of missing practices



Seminars


Exam topics can be downloaded from the website of the Institute of Bioanalysis under the

Education link: http://aok.pte.hu/en/egyseg/oktatas/160

Participants

!Dr. Dergez Tímea (DETCAAT.T.JPTE), Dr. Bufa Anita (BUAEAA.T.JPTE), Dr. Kilár Ferenc (KIFGAAO.PTE), Dr. Makszin Lilla

(MALHAAT.PTE), Dr. Poór Viktória (POVAAA.T.JPTE), Nagy Laura (NALPACT.PTE), Páger Csilla (PACMAAO.PTE)



34

OPA-V2E ORGANIC CHEMISTRY 2 - THEORY



3 credit ▪ final exam ▪ Basic subject ▪ spring semester ▪ recommended semester: 4



Prerequisites: OPA-V1E completed + OPA-M2E completed + OPA-V2G parallel

Topic

This subject is a part of chemistry basics. Its aim to present the nomenclature, structure, physical and chemical properties, synthesis,

reaction mechanisms and application of organic compounds.



Mid-term exams

Students can venture upon the accomplishment of written test two times.


Students have to contact the lecturer of the subject.

Reading material


John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th ed., Thomson Brooks, Belmont, 2007.


- Notes


T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

William H. Brown: Organic Chemistry, Saunders College Publishing, Fort Worth, 1995.

Lectures

1 Nitro compounds: electronic structure, physical, chemical properties, synthesis, reduction of nitro compounds, their nitro-aldol

reaction, biologically important nitro compounds.

Dr. Kálai Tamás



Dr. Kálai Tamás



Dr. Kálai Tamás

4 Amino compounds: Physical, chemical properties, basicity of amines, their synthesis and reactions.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

7 Biologically important amines derived from amino acid decarboxylation; Alkaloids: definition and some representatives.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

10 Aldehydes and ketones: electronic structure of carbonyl group, enol-oxo tautomerism, physical, chemical properties, synthesis

of aldehydes and ketones, their reactions and some representatives; Quinones, vitamin K.






35




13 Carbohydrates: classification of carbohydrates, hemiacetal formation, mutarotation, D- and L-sugars; alpha- and beta-anomers.

Chemical-physical properties of carbohydrates: oxidation, acetylation, bromination, formation of O- and N-glycosides.

Epimerization. Formation of fructose 1,6-diphosphate in aldol reaction.










16 Function and structure of oligosaccharides and polysaccharides; Reducing and non-reducing sugars, the invert sugar. Chemical

reactions of oligosaccharides.








19 Carboxylic acids and their derivatives: Electronic structure of carboxylic acids and their derivatives. Formation and reactivity of

carboxylic acid derivatives, acidity of carboxylic acids. Physical and chemical properties of carboxylic acids. Some biologically

important carboxylic acids; Structure of lipids and phospholipids.










22 Alpha-substituted carboxylic acids: their structure, acidity, biological importance. Carbonic acid derivatives: syntesis, their

utilization in amino acid synthesis and in drug industry.








25 Amino acids, peptides: physical and chemical properties of amino acids (zwitterion formation, chirality) peptide link formation,

amino acid synthesis, peptide synthesis, structure of proteins, general features of proteins and their classification.








28 5-Membered heterocycles with one or two heteroatoms: classification of heterocycles, their nomenclature, electronic structure,

aromaticity, aromatic electrophilic substitution, basicity, virtual tautomerism. Most important and biologically important

representatives.

Dr. Kálai Tamás



representatives.

Dr. Kálai Tamás


36



representatives.

Dr. Kálai Tamás

31 6-Membered heterocycles with one or two heteroatoms: their nomenclature, basicity, electronic structure, eno-oxo amino-imino

tautomerism, aromatic electrophilic substitution, nucleophilic substitution; Most important and biologically active

representatives.

Dr. Kálai Tamás



representatives.

Dr. Kálai Tamás



representatives.

Dr. Kálai Tamás

34 Bases of nucleic acids. Structure of nucleic acids, chemical background to mutations.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

37 Vitamins: classification of vitamins and their biological role.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

40 Summary

Dr. Kálai Tamás

41 Summary

Dr. Kálai Tamás

42 Summary

Dr. Kálai Tamás

Practices

Seminars


1. Alkanes: Orbital hybridization and the structure of alkanes; Nomenclature, physical and chemical properties, combustion, free radical

chlorination, conformation, cycloalkanes, type of ring strains, demonstrate with examples.

2. Unsaturated hydrocarbons: sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and alkynes.

Electrophilic addition, Markovnikov’s rule, 1,2- and 1,4-addition, conjugated and cumulated dienes.

3. Importance of unsaturated hydrocarbons in industry and biology: polymerization, isoprene, terpenes, steroids, carotenoids, polymers,

rubber

4. Aromatic compounds: the structure of benzene, Hückel’s rule. Electrophilic aromatic substitution reactions. (Nitation, sulfonation,

bromination, Friedel-Crafts reactions), direction rules, classification of substituents, polyaromatics: examples, their chemical

reactions aromatic electophilic substitution, oxidation.

5. Alkyl halides: the character of C-X bonds, physical properties, reactivity of alkyl halides, synthesis of alkyl and aromatic halides, and

reactions of alkyl halides (substitution, elimination); Organic halides in the environment.

6. Organometallic compounds: their structure, their importance in organic syntheses (Mg, Na, Li, Si, Cu, Cd compounds).

7. Alcohols, phenols, ethers: Structure, physical and chemical properties, reactions; Their biological importance.

8. Stereochemistry: isomerism, absolute and relative configuration, chirality, racemates, diastereomers, polarimetry, resolution.

9. Sulfur containing compounds: Physical, chemical properties, importance in biological processes (in amino acids, peptides, methylation

in biology, AcCo-A, drugs, sulfonamides, penicillin, cefalosporin).

10. Nitro compounds: electronic structure, physical, chemical properties, synthesis (including aromatic electrophilic nitration), reduction

of nitro compounds, their nitro-aldol reaction, biologically important nitro compounds (glycerine trinitrate, chloroamphenicol).

11. Amino compounds - Physical, chemical properties, basicity of amines (compare aniline, ammonia, methylamine, dimethylamine etc.)

their possible synthesis (alkylation of ammonia, Gabriel synthesis, reductive amination, Hofmann rearrangement), reactions:

Hinsberg reaction, oxidation of amines, reaction with HNO2.

12. Biologically important amines: structure and properties of histamine, tryptamine, choline, acetylcholine, taurine, putrescine,

adrenaline; Alkaloids: definition (structure of mescaline, nicotine, coniine, quinine, papaverine, morphine)


37

13. Aldehydes and ketones: electronic structure of carbonyl group, enol-oxo tautomerism, physical, chemical properties, synthesis of

aldehydes and ketones, their reaction: aldol condensation, Canizzaro-reaction, Silver mirror/Fehling test, oxidation, reaction with

amines, hydrazines, Grignard-reagent, oximes, Beckmann-rearrangement, ketenes, quinones, vitamin K.

14. Carbohydrates: classification of carbohydrates (ketose, aldose, pyranose, furanose, pentose, hexose), hemiacetal formation,

mutarotation, D- and L-sugars; alpha- and beta-anomers. Chemical-physical properties of carbohydrates. The following covalent

structures are required: glucose, fructose, mannose, galactose, ribose, 2-deoxy-ribose, glyceraldehyde, ascorbic acid. Oxidation of

carbohydrates, acetylation, bromination, formation of O- and N-glycosides. Epimerization (glucose, mannose, fructose). Formation

of fructose 1,6-diphosphate in aldol reaction.

15. Function and structure of oligosaccharides and polysaccharides: sucrose, maltose, cellobiose, lactose, kitine, pectine, cellulose, starch.

Reducing sugars and non-reducing sugars, the invert sugar. Chemical reactions of oligosaccharides.

16. Carboxylic acids and their derivatives (acyl chlorides, anhydrides, esters, amides): Electronic structure of carboxylic acids and their

derivatives. Formation of carboxylic acids and their derivatives. Reactivity of carboxylic acid derivatives, acidity of carboxylic acids.

Physical and chemical properties of carboxylic acids. Ester synthesis, Claisen-condensation. Most important carboxylic acids: formic

acid, acetic acid, benzoic acid, oleic acid, linolic and linoleic acid, palmitic and stearic acids, structure of lipids and phospholipids.

17. Alpha-substituted carboxylic acids and carbonic acid: halogenation, lactic acid, pyruvic acid, malonic acid, malonic acid synthesis,

oxalic acid, malic acid, maleic acid, fumaric acid, citric acid. Their structure, acidity, biological importance. Carbonic acid

derivatives: carbonic acid and its esters, phosgene, chloroformic acid esters and their utilization in amino acid synthesis, urea,

thiourea, diureides, barbituric acid and its derivatives, guanidine, creatine.

18. Amino acids, peptides: the exact covalent structure of 20 amino acids, physical and chemical properties (zwitterion formation,

chirality) peptide link formation, amino acid synthesis, glutathione, peptide synthesis, structure of proteins (primary, secondary,

tertiary, quaternary), general features of proteins, their classification with examples, denaturation and colour-reactions of proteins

(Xantoprotein-test, Millon-test etc.)

19. 5-Membered heterocycles: classification of heterocycles, their nomenclature, most important representatives: furane, thiophene,

pyrrole. Heterocycles with two heteroatoms: oxazole, thiazole, imidazole, their electronic structure, aromaticity, aromatic

electrophilic substitution, basicity, virtual tautomerism. Biologically important representatives: biotin, ultraseptil, histamine,

penicillins, aminophenazone, furfural; Indole and its derivatives: serotonine, auxins, indigo.

20. 6-Membered heterocycles: their nomenclature, most important representatives: pyridine, quinoline, isoquinoline, pyrilium,

benzpyrilium cation, their basicity, electronic structure, eno-oxo amino-imino tautomerism, aromatic electrophilic substitution,

nucleophilic substitution, biologically important derivatives: rutin, vitamin E, cyanidium chloride, tetrahydrocannabinol,

nicotinamide, quinine, papaverine, vitamin B6, isoniazide, nifedipine, barbituric acid: veronal, sevenal bases of nucleic acids, base

pairs cytosine, guanine, adenine, timine, uracil, their exact covalent structure, structure of DNA, RNA, vitamin B1, purine: caffeine,

theophylline, theobromine, xanthine, pteridine, structure and function of folic acid.

21. Vitamins: classification of vitamins, their exact covalent structure, their biological role. Vitamin A, vitamin D, Vitamin E, vitamin

K, Vitamin B1, Vitamin B3, Vitamin B5, the role and function of the NAD, Vitamin B6, Vitamin B7, inosite, p-aminobenzoic acid,

folic acid, Vitamin B12, Vitamin C, Vitamin P and flavonoids, Vitamin U.


result different from „failed”)

Participants


38

OPA-V2G ORGANIC CHEMISTRY 2 - PRACTICE



3 credit ▪ midsemester grade ▪ Basic subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 2 – 60 Prerequisites: OPA-V1E completed

Topic

The aims of this course are to introduce students into several basic laboratory techniques and to demonstrate some characteristic reactions

of organic compounds with various functional groups.


During the semester students have to accomplish the preparative works and written tests. They have to document the experiments in their

exercise book.

Mid-term exams

The organic chemistry laboratory course will be graded (1-5), based on the two written tests on 6th and 11th week, first of all. The

evaluation can be modified by grades of semi-micro preparations, success of unknown identification as well as the outlook of the records

of exercise book.


Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.

Reading material



Kálai, T., Bognár, B. Organic Chemisry Laboratory Manual, Dept. of Org. and Med. Chem., Medical Faculty, University of Pécs,

2010.

- Notes


Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London,

1995.

Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd

ed., Wiley, New York, 1994.

Lectures

Practices

1 General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin.



4 Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds.



7 Synthesis of benzil; Identification of 4th unknown compound.



10 Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid and pectin.



13 Acetylation of glucose; Identification of 5th unknown compound;



16 1st written test; Characteristic tube reactions of carboxylic acids; Synthesis of aspirin.



19 Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acid derivatives.




39

22 Synthesis of lidocain (2nd step);



25 Synthesis of heterocycles I.: benzimidazole, 4,5-diphenyl-imidazole; Characteristic tube reactions of heterocycles.



28 Synthesis of heterocycles II.: dilantin, 4-methyl-7-hydroxycoumarine.



31 2nd written test. Isolation of caffeine.



34 Isolation of quercetin and myristic acid.



37 Characteristic tube reactions of amino acids and peptides.



40 Evaluation.

41 Evaluation.

42 Evaluation.

Seminars


The written tests will contain the matter of practice.

Participants

Dr. Bognár Balázs (BOBGAAT.PTE), Dr. Kálai Tamás (KATFABP.PTE), Dr. Pápayné Dr. Sár Cecília (PASFADP.PTE)


40

OPG-GI1 BASIC PRINCIPLES OF PHARMACY

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy

2 credit ▪ midsemester grade ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPO-GB2 completed

Topic

The basic aims of the course are to provide fundamental knowledge of pharmaceutics and gain insight into the pharmaceutical profession.

The subject will support further studies and the summer professional practice by improving vocabulary, professional knowledge, etc..

Further goals are to draw the attention of students towards specific topics (professionalism, roles of pharmacists in healthcare) of

pharmacy, to help students gain interest in practical aspects of pharmaceutical work and to introduce further professional studies.

The course gives an overview of the basic principles of pharmacy and pharmaceuticals. Definitions of the different groups of

pharmaceuticals, synopsis of the process of drug development, evolution and role of pharmacopoeias, sites and aims of small-, medium-

and large scale drug manufacturing, the role of community and clinical pharmacies. During the semester several on-site visits will be

organized to familiarize students with the different fields of pharmacists.

Attendance of, and active participation in the lectures, furthermore understanding of given topics are the basic requirements of completing

the course. Students shall hold a short presentation regarding a previously discussed topic and shall take attend the on site visits organized

by the Institute (community pharmacy, clinical and hospital pharmacy, pharmaceutical industry). Topics discussed during the lectures,

but not included in the notes/books will also be included in the exams. Students can access the slides of the lectures and further reading

material on a designated web based interface (Neptun Meet Street). Prior knowledge from earlier theoretical studies is an advantage.


- Regular attendance of classes/lectures (maximum 25 % of absence is accepted),

- Assignments given in class should be carried out during term-time and,

- The mid-term and end-of-the-term test(s) should be passed (60,1%, minimum grade 2).

Mid-term exams

End-of-semester grade is given by end-of-the-term test’s result, any tests written throughout the semester and student performance during

the semester.

Examination and granting of grades: for Basic Principles of Pharmacy grade (midterm grade) is given based on mid-term and end-of-

the-term test results.

Retake opportunity is possible following personal discussion.


Retake opportunity is possible following personal discussion.

Reading material



All presentations can be downloaded from Neptun Meet Street.

- Notes


Christopher A Langley, Dawn Belcher: Applied Pharmaceutical Practice, 2nd edition, Pharmaceutical Press 2012

Medicines, Ethics and Practice: The Professional Guide for Pharmacists, 36th edition, Royal Pharmaceutical Society of Great Britain,

2012

Lectures

1 Introduction to Basic Principles of Pharmacy. Short presentation of the Department of Pharmaceutics & Central Clinical

Pharmacy

Dr. Fittler András Tamás

2 Pharmacy as a profession. Areas of pharmacy practice


3 Introduction of the product categories found in community pharmacies


4 Routes of administration



41

5 Classification of medications


6 How active substances and medicines are named. Index Nominum


7 Pharmacopoeias and Formularies


8 Contents and format of the medical prescription


9 Handling of the prescription by the pharmacist: Pharmacy Practice Procedures


10 Labelling of dispensed medicines


11 Latin terms and abbreviations, pharmaceutical calculations


12 On site visit to the Central Clinical Pharmacy

Dr. Lankó Erzsébet

13 Getting familiar with ingredients and dosage forms of pharmaceuticals made in pharmacies

Dr. Mayer Anna

14 Manufacturing of medicines and the importance of good manufacturing practice


15 Structure and tasks of a community pharmacy


16 Structure and tasks of a community pharmacy. On site visit


17 Structure and tasks of a clinical pharmacy


18 Structure and tasks of a clinical pharmacy. On site visit


19 Research and development of medicines

Dr. Vida Róbert György

20 Clinical trials

Dr. Vida Róbert György

21 Structure and tasks of the pharmaceutical industry


22 Structure and tasks of the pharmaceutical industry. On site visit


23 Oral presentations of students on pre-arranged topics 1


24 Oral presentations of students on pre-arranged topics 2


25 History of Pharmacy and Medicine (1) from the ancient world to 1100 AD.


26 History of Pharmacy and Medicine (2) in the medieval world form 1100 to 1617 AD.


27 History of Pharmacy and Medicine (3) in the modern world 1841-1986.

Dr. Végh Anna

28 Where are we heading? Pharmacy in the 21st century. Test

Dr. Végh Anna

Practices

Seminars


Based on the topics of the lectures.

Participants


42

OPO-G2E PHARMACOBOTANY 2 - THEORY



1 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 3 – 80 Prerequisites: OPO-G1E completed + OPO-G2G parallel

Topic


systematics discusses the geographical origin of plant species, the possibilities of cultivation and nature conservation. A special emphasis

is laid on chemotaxonomic aspects, since the medicinal effect of a plant is often related to its taxonomic classification and chemical

characteristics. Practical instruction focuses on the knowledge of medicinal plants, including the confident usage of plant identification





Mid-term exams

Students have to pass (min. 60%) two written exams based on lecture materials. If necessary, students will be provided maximum two

extra chances (B and C chance) besides the original exam date (A chance).


Reading material


Á. Farkas: Pharmacobotany 2. University of Pécs, Institute of Pharmacognosy, Pécs, 2017



4.1.2.A/1-11/1-2011-0016

Lecture materials will be available in Neptun.

- Notes


Z. Yaniv, U. Bachrach (eds.): Handbook of Medicinal Plants, Haworth Press Inc., 2005

WHO Monographs on Selected Medicinal Plants, Vol. 1. (1999), Vol. 2. (2002)

Lectures

1 Algae (Phaeophyceae, Rhodophyceae), Fungi, Lichenes

Dr. Farkas Ágnes

2 Pteridophyta, Coniferophytina, Cycadophytina. Magnoliidae.

Dr. Farkas Ágnes

3 Caryophyllidae

Dr. Farkas Ágnes

4 Hamamelididae

Dr. Farkas Ágnes

5 Rosidae I.

Dr. Farkas Ágnes

6 Rosidae II.

Dr. Farkas Ágnes

7 Dilleniidae

Dr. Farkas Ágnes

8 Cornidae

Dr. Farkas Ágnes

9 Lamiidae I.

Dr. Farkas Ágnes

10 Lamiidae II.

Dr. Farkas Ágnes


43

11 Asteridae

Dr. Farkas Ágnes

12 Alismatidae. Liliidae.

Dr. Farkas Ágnes

13 Zingiberidae

Dr. Farkas Ágnes

14 Commelinidae, Arecidae

Dr. Farkas Ágnes

Practices

Seminars



result different from „failed”).

Final exam:

Entrance exam:

Preceding the oral exam, 5 medicinal plants should be identified and their brief morphological characterization should be given.

Oral exam:

Following the successful entrance exam, students are required to present their knowledge on 2 topics from the list below. The general

characterization of plant families should be followed by the morphological and chemotaxonomic description of the species belonging

to the given families.

Exam questions:

1. Algae, Fungi, Lichenes

2. Lycopodiaceae, Equisetaceae, Aspidiaceae, Polypodiaceae

3. Ginkgoaceae, Abietaceae, Cupressaceae, Taxaceae, Ephedraceae

4. Myristicaceae, Illiciaceae, Lauraceae, Piperaceae, Aristolochiaceae

5. Berberidaceae, Ranunculaceae (Helleboraceae)

6. Papaveraceae, Fumariaceae

7. Chenopodiaceae, Caryophyllaceae, Polygonaceae

8. Hamamelidaceae, Fagaceae, Betulaceae (Corylaceae), Juglandaceae

9. Droseraceae, Rosaceae

10. Mimosaceae, Caesalpiniaceae, Fabaceae

11. Myrtaceae, Punicaceae, Lythraceae, Onagraceae

12. Rutaceae, Anacardiaceae

13. Hippocastanaceae, Geraniaceae, Linaceae, Erythroxylaceae

14. Polygalaceae, Krameriaceae, Rhamnaceae, Vitaceae, Loranthaceae

15. Araliaceae, Apiaceae

16. Violaceae, Passifloraceae, Caricaceae, Cucurbitaceae

17. Brassicaceae, Salicaceae

18. Tiliaceae, Sterculiaceae, Malvaceae

19. Moraceae, Cannabaceae

20. Urticaceae, Euphorbiaceae

21. Elaeagnaceae, Theaceae, Hypericaceae, Primulaceae

22. Aquifoliaceae, Caprifoliaceae (Sambucaceae), Valerianaceae, Ericaceae

23. Loganiaceae, Rubiaceae

24. Apocynaceae, Gentianaceae, Menyanthaceae, Oleaceae

25. Solanaceae, Convolvulaceae

26. Boraginaceae, Scrophulariaceae

27. Plantaginaceae, Pedaliaceae, Verbenaceae

28. Lamiaceae

29. Lobeliaceae, Asteraceae (Cichoriaceae)

30. Dioscoreaceae, Convallariaceae, Asparagaceae, Ruscaceae, Agavaceae

31. Asphodelaceae, Hyacinthaceae, Alliaceae

32. Amaryllidaceae, Melanthiaceae, Colchicaceae, Iridaceae, Orchidaceae

33. Zingiberaceae, Bromeliaceae, Poaceae, Arecaceae

Participants


44

OPO-G2G PHARMACOBOTANY 2 - PRACTICE



2 credit ▪ midsemester grade ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 3 – 80 Prerequisites: OPO-G1E completed

Topic


systematics discusses the geographical origin of plant species, the possibilities of cultivation and nature conservation. A special emphasis

is laid on chemotaxonomic aspects, since the medicinal effect of a plant is often related to its taxonomic classification and chemical

characteristics. Practical instruction focuses on the knowledge of medicinal plants, including the confident usage of plant identification





Mid-term exams

From the 2nd week onwards, students have to write a short test each week (recognising and characterising 5-5 medicinal plants).

In the practice, students have to take notes and prepare drawings based on macroscopic and microscopic examinations. Students have to

show their lab notebook to the practice leader, who acknowledges fulfillment of the practice by his/her signature.

The grade for the practice will be made up by the grades from each week’s test and the lab notebook.


Missed practicals can be made up either by joining the other groups or taking extra time at the following lab practical. In all cases,

students must make arrangements with their lab instructors in advance.

Reading material


Á. Farkas: Pharmacobotany 2. University of Pécs, Institute of Pharmacognosy, Pécs, 2017

N. Papp: Pharmacobotany Practices. University of Pécs, Institute of Pharmacognosy, Pécs, 2011



4.1.2.A/1-11/1-2011-0016

- Notes


Z. Yaniv, U. Bachrach (eds.): Handbook of Medicinal Plants, Haworth Press Inc., 2005

Lectures

Practices

1 Fungi: Morphology of Ganoderma lucidum, Fomes fomentarius and Lentinus edodes. Lichenes: Morphological comparison of

Cladonia pyxidata and Cetraria islandica.

2 Pteridophyta: Spores and sporangia of Lycopodium clavatum and Equisetum arvense; rhizome of Dryopteris filix-mas.

3 Spermatophyta: Coniferophytina: Inflorescences, needles and wood of Pinus nigra. Angiospermatophytina: Dicotyledonopsida:

Magnoliidae: Aristolochiaceae.

4 Ranunculaceae, Helleboraceae. Aristolochia shoot, Ficaria root and leaf, Helleborus leaf.

5 Berberidaceae, Papaveraceae, Fumariaceae, Papaver sp. pistil and fruit.

6 Caryophyllidae: Phytolaccaceae, Polygonaceae, Caryophyllaceae. Saponaria officinalis root.

7 Hamamelididae: Fagaceae, Betulaceae, Juglandaceae. Leaf morphology and fruit types of Fagus and Quercus species. Juglans

regia fruit.

8 Plant identification practice with identification key.

9 Rosidae I.: Grossulariaceae, Crassulaceae, Rosaceae. Sedum sp. shoot, Rosa canina pseudofruit, Malus domestica nectary,

Rosaceae fruit types.

10 Rosidae I.: Fabaceae. Starch grains of Phaseolus vulgaris and Pisum sativum.

11 Rosidae II.: Araliaceae: Morphological features of Hedera helix and Panax ginseng. Apiaceae. Fruit of Carum carvi and

Foeniculum vulgare.

12 Rosidae II.: Punicaceae, Lythraceae, Onagraceae, Rutaceae. Hesperidium and shoot of Citrus limon.


45

13 Rosidae III.: Anacardiaceae, Hippocastanaceae, Geraniaceae, Celastraceae, Rhamnaceae. Pelargonium zonale non-glandular and

glandular trichomes.

14 Rosidae III.: Vitaceae, Araliaceae, Violaceae, Cistaceae, Cucurbitaceae. Shoot of Bryonia alba or Cucumis sativus with

bicollateral vascular bundles.

15 Dilleniidae: Brassicaceae, Salicaceae, Tiliaceae, Cannabaceae. Bifid hairs and glandular scales of Humulus lupulus.

16 Dilleniidae: Malvaceae, Moraceae, Urticaceae, Buxaceae. Urtica dioica stinging hairs. Euphorbiaceae, Elaeagnaceae,

Hypericaecae. Laticifers and starch grains of Euphorbia sp., stellate hairs of Elaeagnus angustifolia. Primulaceae.

17 Cornidae: Caprifoliaceae, Valerianaceae, Rubiaceae. Sambucus nigra shoot. Apocynaceae. Asclepiadaceae. Nerium oleander

leaf.

18 Plant identification practice.

19 Lamiidae I.: Solanaceae: Solanum tuberosum starch grains. Convolvulaceae. Boraginaceae, Plantaginaceae.

20 Lamiidae I.: Boraginaceae non-glandular trichomes. Scrophulariaceae, Verbenaceae. Verbascum phlomoides hairs.

21 Lamiidae II.: Lamiaceae.

22 Lamiidae II.: Lamiaceae-type glandular hairs on the leaf of Lavandula sp.. Salvia officinalis shoot.

23 Asteridae: Asteraceae

24 Asteridae: Secondary thickening in the stem of Helianthus annuus. Taraxacum officinale rhizome.

25 Monocotyledonopsida: Dioscoreaceae, Convallariaceae, Asparagaceae, Ruscaceae. Convallaria majalis rhizome.

26 Monocotyledonopsida: Alliaceae, Orchidaceae, Poaceae. Root tip and leaf of Allium sp., scale leaves of Allium cepa.

27 Visit to the botanical garden.

28 Visit to the medicinal plant garden.

Seminars


Participants

Dr. Papp Nóra (PANAAA.T.JPTE)


46

OPO-H2E HUMAN PHYSIOLOGY 2 - THEORY



3 credit ▪ final exam ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPO-H1E completed + OPO-H2G parallel

Topic













Mid-term exams




Reading material








- Notes



2016






Lectures

1 Endocrinology of the adrenal cortex. I.


2 Endocrinology of the adrenal cortex. II.


3 The adrenal medulla. Endocrinology of stress


4 Hormonal control of intermediary metabolism.

Dr. Zelena Dóra

5 Hormonal control of calcium homeostasis

Dr. Zelena Dóra


47

6 The endocrine pancreas

Dr. Lengyel Ferenc

7 Special problems of neonatal physiology. Physiology of ageing

Dr. Lengyel Ferenc

8 Ionic mechanism of membrane potential. Action potential and its propagation.

Dr. Buzás Péter

9 Electrophysiology of synapses. Neurochemical basis of neurotransmission. Function of the neuromuscular junction.

Dr. Buzás Péter

10 Molecular mechanism of muscle contraction. Mechanics, energetics and heat production of muscle contraction.


11 Electric characteristics of muscle contraction, muscle tone, fatigue. Contraction of smooth muscle.


12 The motor unit. Peripheral neural mechanism of muscle control.


13 Functional importance of mechanoreceptors

Dr. Buzás Péter

14 General properties of spinal cord reflexes. Integrative functions of the spinal cord.


15 The spinal shock. Decerebrate rigidity.


16 Postural coordination, Locomotion.


17 Extrapyramidal system.

Kertes Erika

18 Physiology of the vestibular system.

Dr. Ollmann Tamás

19 Cerebellar control of motor functions.

Dr. Ollmann Tamás

20 Cortical control of motor functions. The pyramidal system.

21 Somaesthetic mechanisms. Somatotopic representations in the sensory systems.

Dr. Buzás Péter

22 Thalamocortical somatosensory functions. The sensory cortex.

Dr. Buzás Péter

23 Pain mechanism.

Dr. Buzás Péter

24 Optics of vision, refractory errors of the eye. Retinal mechanisms.

Dr. Nemes Vanda

25 Visual pathways, midbrain mechanism of vision. Central mechanism of vision.

Dr. Nemes Vanda

26 Eye movements and their control.

Dr. Nemes Vanda

27 Physiology of hearing. Central auditory mechanisms.


28 The chemical senses. Olfaction. Taste.

Dr. Szabó István

29 The autonomic nervous system.


30 Electroencephalography.


31 Neural control mechanism of sleep. Clinical importance of the evoked potential technique.


32 The diencephalon (hypothalamus). Its motor, autonomic and hormonal regulatory functions.

Dr. Ollmann Tamás

33 The concept of drive and motivation. Homeostatic drives.

Dr. Ollmann Tamás

34 Central neural regulation of hunger and thirst. Control of biological rhythms.

Dr. Szabó István


48

35 The limbic system.


36 Monoaminergic systems and their functions.


37 Emotions and their central nervous mechanism.

Dr. Ollmann Tamás

38 Mechanism of learning.


39 Types and disorders of memory functions.


40 Plasticity of the peripheral and central nervous system. Functions of the frontal lobe.

Dr. Varga Csaba

41 The parieto-temporal lobe.


42 Cerebral hemisphere dominance. Neurophysiological mechanisms of speech. Speech disorders.


Practices

Seminars



result different from „failed”).
















cell








22. The heart-lung preparation (Starling’s laws)








30. Cerebral circulation. The concept of blood-brain barrier






49





















































85. The endocrine pancreas

86. Function of insulin in the body. Diabetes mellitus

87. Hormonal control of carbohydrate metabolism

88. Hormonal control of calcium and phosphor homeostasis

89. Hormonal function of the adrenocortical system. Hypophyseal regulation of the adrenocortical system. Stress and the adaptation

syndrome

90. Function and regulation of mineralocorticoids


50

91. Function and regulation of glucocorticoids

92. Consequences of hypo- and hyperfunction of the adrenal cortex. Androgens and oestrogens of the adrenal cortex.

93. Hormones of the adrenal medulla. Importance of the sympathoadrenal system

94. Physiology of ontogenesis and ageing.

95. Molecular mechanism of muscle contraction. The regulatory role of calcium ion

96. Mechanical characteristics of muscle. Differentiation of fast and slow twitch muscle fibres. Role of the connective tissue in the

function of muscles

97. Mechanism of fatigue

98. Electromyography (EMG)

99. The source of energy for muscle contraction (aerobe and anaerobe processes). Heat production during contraction-relaxation cycle

100. The neuromuscular junction

101. Structural and functional differences between skeletal and smooth muscles. Mechanism of smooth muscle contraction

102. Membrane potential and action potential: explain their ionic mechanisms. Membrane properties of CNS neurons

103. The compound action potential. Conductive properties of various nerve fibres

104. Neurochemistry of synapses, neurotransmitters, postsynaptic receptors and neuromodulators. EPSP, IPSP

105. The myotatic (stretch) reflex. Gamma motoneurons

106. The motor units. Central control of muscle contractions

107. Types of mechanoreceptors and their role in motor control

108. How do cutaneous mechanoreceptors help to explore, learn and know our environment?

109. Somatosensory mechanisms of spinal cord and brain stem

110. Pain mechanisms, central and peripheral components

111. Descendent control (gating) of nociception and of pain reactions

112. Organisation of primary somatosensory cortex, thalamocortical projection and somatotopy

113. The human electroencephalogram (EEG). Evoked potential (EP) technique

114. Neural mechanisms of sleep and correlated somatic, autonomic and bioelectrical phenomena. The role of reticular formation in the

sleep-wakefulness cycle

115. The diencephalon (hypothalamus), its motor, autonomic and hormonal regulatory function

116. Hunger and thirst. Central regulatory processes of food and water intake

117. Central mechanisms of locomotion

118. Decerebration rigidity and spinal shock (symptoms and mechanisms)

119. Postural and righting reflexes, their central mechanisms and localisation within the spinal cord, brain stem and neocortex

120. Structure and function of the extrapyramidal system

121. Symptoms after damages of different extrapyramidal structures. Role of neurotransmitters in the extrapyramidal functions

122. Importance of the cerebellum in co-ordination of movements

123. Cerebellar cortical mechanisms

124. Structure and function of the vestibular system

125. Functions of the autonomic nervous system. Autonomic reflexes

126. Humoral mediators in the autonomic nervous system. Adrenergic, cholinergic and opioid receptors

127. Structures, connections and functions of the limbic system

128. Functions of the motor cortex. Symptoms following its damage

129. Corticospinal (pyramidal) system. Consequences of lesions of the pyramidal pathways and the peripheral motoneuron

130. The concept of drive and motivation. Their integrated neural mechanisms. Reticular activating system

131. Emotions and their central nervous mechanisms

132. The phenomena of operant (instrumental) and classical (Pavlovian) conditioning. Mechanism of reinforcement

133. Electrical and chemical self-stimulation. Rewarding (positive) and punishing (negative) reinforcement. Simple learning processes.

Exceptional forms of conditioning

134. Types and disorders of memory functions

135. Cerebral dominance. Lateralisation of functions in the hemispheres. Split-brain examinations

136. Functions of the parietal and temporal association (intrinsic) areas of the neocortex. Symptoms after damages (apraxia, agnosia)

137. Neurophysiological mechanisms of speech. Speech disorders

138. Functions of the frontal lobe (prefrontal intrinsic area)

139. Functions of the temporal lobe (Kluver-Bucy syndrome)

140. Central monoaminergic systems and their functional significance

141. Peripheral auditory mechanisms (conductive apparatus and cochlea)

142. Central auditory pathways, acoustic cortex and related mechanisms

143. Physiological optics

144. The retina. Photoreceptors and neuronal functions in the retina

145. Central visual pathways, the visual cortex and their functions

146. Colour vision. Stereoscopic vision


51

147. Peripheral and central mechanisms of olfaction

148. Peripheral and central mechanisms of sensation of taste

149. Plasticity in the nervous system. Consequences of sensory deprivation in the visual cortex. Ageing. Transplantation


1. Examination of oestrus cycle in rat

2. Different tests of pregnancy

3. Determination of human blood glucose level

4. Direct and indirect stimulation of nerve-muscle preparation;

5. Recording of a twitch contraction; Effects of repetitive stimulation muscles (complete and incomplete tetanus)

6. Effect of load on muscular contraction

7. Examination of fatigue in nerve-muscle preparation and on humans

8. Electromyographic registration methods (EMG)

9. Measurement of conduction velocity

10. Recording of a compound action potential of peripheral nerve trunks

11. The law of polar excitation

12. Demonstration of the Pflüger’s law

13. Measurement of rheobase and chronaxy

14. Effect of narcosis on peripheral nerves

15. Examination of reflexes in a frog (intact and spinal animal)

16. Examination of reflexes in the human

17. Stereotaxic technique

18. Reflex time, reaction time and action time

19. Electroencephalogram (EEG)

20. Measurement of visual acuity

21. Refractive errors and their corrections

22. Measurement of astigmia

23. Examination of pupil reactions

24. Perimetry

25. Examination of colour weakness and colour blindness

26. Audiometry

Study material for the final exam is the sum total of information covered in the obligatory textbook, on the homepage of the Institute, as

well as knowledge given at the lectures and lab practices.

Participants


52

OPO-H2G HUMAN PHYSIOLOGY 2 - PRACTICE



2 credit ▪ midsemester grade ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPO-H1E completed

Topic













Mid-term exams




Reading material








- Notes



2016






Lectures

Practices

1 The endocrine pancreas.

2 The endocrine pancreas.

3 Reproduction.

4 Reproduction.

5 Peripheral nervous system I.

6 Peripheral nervous system I.

7 Peripheral nervous system II.

8 Peripheral nervous system II.


53

9 Seminar: Endocrinology, Peripheral nerve, Membrane potential, Action potential, Synaptic transmission.

10 Student report (test).

11 Experiments on muscles.

12 Experiments on muscles.

13 Electromyography, Examination of fatigue.

14 Electromyography, Examination of fatigue.

15 Examination of reflexes.

16 Examination of reflexes.

17 Central nervous system.

18 Central nervous system.

19 Seminar: Muscle and reflexes.

20 Student report (test).

21 Sensory organs I.

22 Sensory organs I.

23 Sensory organs II.

24 Sensory organs II.

25 Electroencephalography in humans.

26 Electroencephalography in humans.

27 Student lab report.

28 Student lab report.

Seminars

















cell








22. The heart-lung preparation (Starling’s laws)








30. Cerebral circulation. The concept of blood-brain barrier






54





















































85. The endocrine pancreas

86. Function of insulin in the body. Diabetes mellitus

87. Hormonal control of carbohydrate metabolism

88. Hormonal control of calcium and phosphor homeostasis

89. Hormonal function of the adrenocortical system. Hypophyseal regulation of the adrenocortical system. Stress and the adaptation

syndrome

90. Function and regulation of mineralocorticoids


55

91. Function and regulation of glucocorticoids

92. Consequences of hypo- and hyperfunction of the adrenal cortex. Androgens and oestrogens of the adrenal cortex.

93. Hormones of the adrenal medulla. Importance of the sympathoadrenal system

94. Physiology of ontogenesis and ageing.

95. Molecular mechanism of muscle contraction. The regulatory role of calcium ion

96. Mechanical characteristics of muscle. Differentiation of fast and slow twitch muscle fibres. Role of the connective tissue in the

function of muscles

97. Mechanism of fatigue

98. Electromyography (EMG)

99. The source of energy for muscle contraction (aerobe and anaerobe processes). Heat production during contraction-relaxation cycle

100. The neuromuscular junction

101. Structural and functional differences between skeletal and smooth muscles. Mechanism of smooth muscle contraction

102. Membrane potential and action potential: explain their ionic mechanisms. Membrane properties of CNS neurons

103. The compound action potential. Conductive properties of various nerve fibres

104. Neurochemistry of synapses, neurotransmitters, postsynaptic receptors and neuromodulators. EPSP, IPSP

105. The myotatic (stretch) reflex. Gamma motoneurons

106. The motor units. Central control of muscle contractions

107. Types of mechanoreceptors and their role in motor control

108. How do cutaneous mechanoreceptors help to explore, learn and know our environment?

109. Somatosensory mechanisms of spinal cord and brain stem

110. Pain mechanisms, central and peripheral components

111. Descendent control (gating) of nociception and of pain reactions

112. Organisation of primary somatosensory cortex, thalamocortical projection and somatotopy

113. The human electroencephalogram (EEG). Evoked potential (EP) technique

114. Neural mechanisms of sleep and correlated somatic, autonomic and bioelectrical phenomena. The role of reticular formation in the

sleep-wakefulness cycle

115. The diencephalon (hypothalamus), its motor, autonomic and hormonal regulatory function

116. Hunger and thirst. Central regulatory processes of food and water intake

117. Central mechanisms of locomotion

118. Decerebration rigidity and spinal shock (symptoms and mechanisms)

119. Postural and righting reflexes, their central mechanisms and localisation within the spinal cord, brain stem and neocortex

120. Structure and function of the extrapyramidal system

121. Symptoms after damages of different extrapyramidal structures. Role of neurotransmitters in the extrapyramidal functions

122. Importance of the cerebellum in co-ordination of movements

123. Cerebellar cortical mechanisms

124. Structure and function of the vestibular system

125. Functions of the autonomic nervous system. Autonomic reflexes

126. Humoral mediators in the autonomic nervous system. Adrenergic, cholinergic and opioid receptors

127. Structures, connections and functions of the limbic system

128. Functions of the motor cortex. Symptoms following its damage

129. Corticospinal (pyramidal) system. Consequences of lesions of the pyramidal pathways and the peripheral motoneuron

130. The concept of drive and motivation. Their integrated neural mechanisms. Reticular activating system

131. Emotions and their central nervous mechanisms

132. The phenomena of operant (instrumental) and classical (Pavlovian) conditioning. Mechanism of reinforcement

133. Electrical and chemical self-stimulation. Rewarding (positive) and punishing (negative) reinforcement. Simple learning processes.

Exceptional forms of conditioning

134. Types and disorders of memory functions

135. Cerebral dominance. Lateralisation of functions in the hemispheres. Split-brain examinations

136. Functions of the parietal and temporal association (intrinsic) areas of the neocortex. Symptoms after damages (apraxia, agnosia)

137. Neurophysiological mechanisms of speech. Speech disorders

138. Functions of the frontal lobe (prefrontal intrinsic area)

139. Functions of the temporal lobe (Kluver-Bucy syndrome)

140. Central monoaminergic systems and their functional significance

141. Peripheral auditory mechanisms (conductive apparatus and cochlea)

142. Central auditory pathways, acoustic cortex and related mechanisms

143. Physiological optics

144. The retina. Photoreceptors and neuronal functions in the retina

145. Central visual pathways, the visual cortex and their functions

146. Colour vision. Stereoscopic vision


56

147. Peripheral and central mechanisms of olfaction

148. Peripheral and central mechanisms of sensation of taste

149. Plasticity in the nervous system. Consequences of sensory deprivation in the visual cortex. Ageing. Transplantation


1. Examination of oestrus cycle in rat

2. Different tests of pregnancy

3. Determination of human blood glucose level

4. Direct and indirect stimulation of nerve-muscle preparation;

5. Recording of a twitch contraction; Effects of repetitive stimulation muscles (complete and incomplete tetanus)

6. Effect of load on muscular contraction

7. Examination of fatigue in nerve-muscle preparation and on humans

8. Electromyographic registration methods (EMG)

9. Measurement of conduction velocity

10. Recording of a compound action potential of peripheral nerve trunks

11. The law of polar excitation

12. Demonstration of the Pflüger’s law

13. Measurement of rheobase and chronaxy

14. Effect of narcosis on peripheral nerves

15. Examination of reflexes in a frog (intact and spinal animal)

16. Examination of reflexes in the human

17. Stereotaxic technique

18. Reflex time, reaction time and action time

19. Electroencephalogram (EEG)

20. Measurement of visual acuity

21. Refractive errors and their corrections

22. Measurement of astigmia

23. Examination of pupil reactions

24. Perimetry

25. Examination of colour weakness and colour blindness

26. Audiometry

Study material for the final exam is the sum total of information covered in the obligatory textbook, on the homepage of the Institute, as

well as knowledge given at the lectures and lab practices.

Participants

Kovács Anita (KOAMAET.PTE), Péczely László Zoltán (PELHAAO.PTE)


57

ATT4 PHYSICAL EDUCATION 4

Course director: TAMÁS TÉCZELY, physical education teacher

UP MS Sports Facilities



Course headcount limitations (min.-max.): 2 – 50 Prerequisites: ATT3 completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to

deepen the knowledge in the field of healthy lifestyle.

Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and

how to prevent the body from injuries.


Active participation at least 20 practical lessons provided by the Institute of Human Movement Sciences or regular participation of the

trainings of the Medikus Sport Club or PEAC.

Mid-term exams

-


We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the

end of the teaching weeks with agreement of the PE Teacher.

Reading material



Not available.

- Notes

Recommended literature Lectures Practices

1-28 For the list of actual courses please turn to the end of this document

Seminars


Participants

Farkas György (FAGMAAO.PTE), Lipcsik Zoltán (LIZIAAT.PTE), Németh Attila Miklós (NEAGAET.PTE), Téczely Tamás

(PETLAAT.PTE)


58

ATT1-2-3-4-5 PHYSICAL EDUCATION COURSES 1-2-3-4-5

Sport day from to place min.

head-count

max. head-count

supervisor trainer

Aerobics Monday 18:00 19:00 SPO-SOR Sörház 2nd floor (Xavér u. 19.)

2 8 Dr. Szilárdné Kordély Erika

Aerobics Tuesday 19:00 20:00 SZEA-EDZ Main Building training room

2 8 Pajor Marietta

Aerobics Wednesday 18:00 19:00 SPO-SOR Sörház 2nd floor (Xavér u. 19.)


Aerobics Wednesday 19:00 20:00 SPO-SOR Sörház 2nd floor (Xavér u. 19.)

2 8 Pajor Marietta

Aerobics Thursday 18:00 19:00 SPO-SOR Sörház 2nd floor (Xavér u. 19.)


Aerobics (pompom) Tuesday 20:00 21:30 SPO-PSM "Pécsi Sasok" Sportscenter (Búza tér 6/b.)

2 6 Rill Laura

Athletics Monday 17:00 18:30 SPO-ATP Faculty of Sciences - Athletics field (Ifjúság út 6.)

1 8 Hajduné Dr. László Zita

Athletics Wednesday 16:00 17:30 SPO-ATP Faculty of Sciences - Athletics field (Ifjúság út 6.)


Badminton (Student Sports Club) Thursday 16:30 17:45 SPO-TCS Sportshall at Jakabhegyi út (Jakabhegyi út 6.)

2 7 Farkas György

Lipcsik Zoltán

Basketball (men) Thursday 22:00 23:30 SPO-TCS Sportshall at Jakabhegyi út (Jakabhegyi út 6.)

4 20 Németh Attila Miklós

Basketball (women) (Student Sports Club)

Wednesday 18:00 19:30 SPO-TCS Sportshall at Jakabhegyi út (Jakabhegyi út 6.)

2 6 Farkas György

Németh Attila Miklós

Body Slim Monday 19:00 20:00 SPO-MFK Mecsek Fitness (Ybl Miklós u. 10.)

2 7 Szőke Zita

Cardio Yoga Friday 15:00 16:30 SZEA-EDZ Main Building training room

2 10 Ragács Renáta

Climbing Thursday 17:30 19:00 SPO-PSM "Pécsi Sasok" Sportscenter (Búza tér 6/b.)

2 6 Téczely Tamás

Cross Training Monday 20:00 21:30 SPO-CRF Cross Factory, in the yard of the Professor Gym (Megyeri út 4.)

1 6

Téczely Tamás

Dancing University Project - Ballroom Dancing

Thursday 19.00 20:30 SPO-I6T Dance room (Ifjúság út 6.)

1 4 Bánkyné Perjés Beatrix

Dr. Papp Judit

Dancing University Project - Ballroom Latin Dances

Tuesday 20:30 22:00 SPO-I6T Dance room (Ifjúság út 6.)


Józsa János

Dancing University Project - Belly Dance

Thursday 17:30 19:00 SPO-I6T Dance room (Ifjúság út 6.)


Indzsi Deniz

Dancing University Project - Body Shaping Dance Aerobics



Szalai Kata

Dancing University Project - Croatian, Serbian and Macedonian Dances



Vélin Veszna


59

Dancing University Project - Cuban Salsa

Wednesday 17:45 19:15 SPO-I6T Dance room (Ifjúság út 6.)


Vágási Barbara, Kutni Balázs

Dancing University Project - Hip-hop

Monday 18:30 20:00 SPO-I6T Dance room (Ifjúság út 6.)


Horváth Tamás

Dancing University Project - Latin Freestyle Aerobics

Monday 17:00 18:30 SPO-I6T Dance room (Ifjúság út 6.)


Szabó Adrienn

Dancing University Project - Pole Fitness



Dombai Szilvia

Dancing University Project - Self-defence

Friday 13.00 14.15 SPO-I6T Dance room (Ifjúság út 6.)


Lenkei Zsolt

Dancing University Project - Yoga Wednesday 15:00 16:30 SPO-I6T Dance room (Ifjúság út 6.)


Gyenis Boglárka

Football Friday 13:30 15:00 SPO-TCS Sportshall at Jakabhegyi út (Jakabhegyi út 6.)

6 15 Téczely Tamás

Football Friday 15:00 16:30 SPO-TCS Sportshall at Jakabhegyi út (Jakabhegyi út 6.)


Handball (men) (Student Sports Club)


2 7 Farkas György

Lipcsik Zoltán

Handball (women) (Student Sports Club)

Monday 17:30 19:00 SPO-TCS Sportshall at Jakabhegyi út (Jakabhegyi út 6.)

2 7 Farkas György

Lipcsik Zoltán

Hiking weekends

Mecsek 2 10 Farkas György

Horse Riding (six times) Saturday 9:00 13:00

SPO-APL "Apró Paták" Riding School (Siklós, Postaszállás u. 11.) (transportation is provided)

1 2 Téczely Tamás

Bohár Áron

Karate advanced (Student Sports Club)

Tuesday 20:00 21:30 SZEA-EDZ Main Building training room

2 7 Farkas György

József Kristóf

Karate advanced (Student Sports Club)

Thursday 20:00 21:30 SZEA-EDZ Main Building training room

2 7 Farkas György

József Kristóf

Kick-box Friday 19:00 20:30 SZEA-EDZ Main Building training room

2 12 Horváth László

Lacross Friday 19:00 20:30 SPO-V13 UP Sports fields (Verseny u. 13.)

2 10 Dr. Rugási Endre

Nordic Walking Wednesday 17:30 19:00 SPO-ATP Faculty of Sciences - Athletics field (Ifjúság út 6.)


Operational Medicine Training Program (functional skill development)

Tuesday 16:15 17:30 SZEA-EDZ Main Building training room

1 6 Lipcsik Zoltán

Other sports clubs from Pécs (with permission)



60

PTE- PEAC (Sport Club) (with permission)


Shaolin Kung Fu Monday 19:00 20:30 SPO-EP8 Elementary School "Éltes Mátyás" (Építők u. 8.)

1 4 Bornemissza Gergely

Squash Friday 16:30 18:00 SPO-SOR Sörház 2nd floor (Xavér u. 19.)

2 4 Téczely Tamás

Swimming Tuesday 12:00 13:30 SZEA-USZ Main Building swimming pool

1 4 Dr. Karsai István

Swimming Wednesday 18.00 19.30 SPO-UIF Faculty of Sciences Swimming pool (Ifjúság út 6.)


Swimming Friday 13:30 15:00 SZEA-USZ Main Building swimming pool

3 15 Farkas György

Swimming Friday 15:00 16:00 SZEA-USZ Main Building swimming pool

3 15 Finak Gáborné Gombosi Eszter Gyöngyi

Table Tennis Friday 13:30 15:00 SZEA-EDZ Main Building training room


Table Tennis Thursday 13:30 15:00 SZEA-EDZ Main Building training room


Table Tennis Thursday 15:00 16:15 SZEA-EDZ Main Building training room

4 16 Farkas György

Tennis Monday 18:00 19:00 SPO-MAT Makár Tanya (Középmakár dűlő 4.)

2 6 Daróczi Balázs

Tennis Tuesday 17:00 18:00 SPO-MAT Makár Tanya (Középmakár dűlő 4.)

2 3 Daróczi Balázs

Track and Field training Friday 17:00 18:30 SPO-JSK Jakabhegy street outdoor handball field (Jakabhegyi út 6.)


Training in the Gym Wednesday 12:00 13:30 SPO-GYM Professors' Gym (Megyeri út 4.)

2 10 Lipcsik Zoltán

Training in the Gym Friday 12:00 13:30 SPO-GYM Professors' Gym (Megyeri út 4.)

4 20 Lipcsik Zoltán

Training in the Gym Friday 13:30 15:00 SPO-GYM Professors' Gym (Megyeri út 4.)

4 20 Németh Attila Miklós

VitalFUN Tuesday 19:15 20:30 SPO-RSG Faculty of Sciences rhythmic gymnastics room (Ifjúság út 6. Building A)

1 2 Dr. Dudás Anna

Volleyball (women) (Student Sports Club)

Tuesday 16:30 18:00 SPO-TCS Sportshall at Jakabhegyi út (Jakabhegyi út 6.)

2 7 Farkas György

Schrauff Júlia

Volleyball (women) (Student Sports Club)


2 7 Farkas György

Balla Róbert

Yoga Sunday 18:00 20:00 SPO-SOR Sörház 2nd floor (Xavér u. 19.)

2 10 Kisföldi-Szabó Ágnes

Zumba (fee payment necessary) Wednesday 18:00 19:00 SPO-FOR Fordan Dance Center (Batthyány u. 9/a.)

2 16 Varga Zsuzsanna


61

OPR-SG1 PROFESSIONAL PRACTICE 1

Course director: DR. ANDRÁS TAMÁS FITTLER, assistant professor

Department of Pharmaceutics and University Pharmacy

0 credit ▪ signature ▪ Criterion requirement subject ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 70 Prerequisites: OPG-GI1 parallel + OPG-GPR completed

Topic

Aim of summer pharmacy practice after the 4th semester is to expose the pharmacy as a healthcare institution.

Student is allowed to execute the practice in a pharmacy or in a clinical/hospital pharmacy or in pharmaceutical industry/factory. It is

also allowed to split the four week practice into 2-2 weeks in order to spend the practice at both places.

Proposal in the Hungarian pharmacy practice with Hungarian Student together.


Student can only work under the supervision of the tutor pharmacist or other assigned person.

Brief daily report must be done during the practice which has to be presented on course of Pahrmaceutical Technology 1.

Mid-term exams


4 weeks of practice can be split into two parts due to illness.

Reading material


White coat, Protective shoes


- Notes

Pharmaceutical Propedeutic, Basic Principles of Pharmacy,


European Pharmacopoeia

Pharmacopoeia Hungarica

Hungarian National Formulary: Formulae Normales VII (FoNo VII)

Compendium

Lectures

Practices

Knowing duties of pharmacists and the pharmacy

Knowing places in pharmacy

Storage of medicines, assuring storing conditions in pharmacy

Pharmaceutical appliances, instrumentation, knowing scales

Studying pharmaceutical ingredients, excipients

Packaging and labeling magistral preparations

Practicing basic technological procedures

Knowing rules and regulations of work in pharmacy

..

Pharmaceutical factory

Pharmaceutical industry works

Good Manufactory Practice (GMP)

The key persons in the factory

Quality Assurance, Qualify Person, responsibility

Production area, production process

Microbiology in the pharmaceutical industry

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice.


62

Participants

Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr.

Börzsei Rita Judit (BORPAAO.PTE)


63

OPR-HUF-O FINAL EXAMINATION IN HUNGARIAN PHARMACEUTICAL TERMINOLOGY - ORAL

Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor

Department of Languages for Specific Purposes



Course headcount limitations (min.-max.): 1 – 400 Prerequisites: none

Topic

Exam of Pharmaceutical Hungarian language skills required for the pharmaceutical practice.


-

Mid-term exams

-


-

Reading material



- Notes


Lectures

Practices

Seminars


-

Participants


64

OPR-HUF-W FINAL EXAMINATION IN HUNGARIAN PHARMACEUTICAL TERMINOLOGY - WRITTEN

Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor

Department of Languages for Specific Purposes



Course headcount limitations (min.-max.): 1 – 400 Prerequisites: none

Topic

Exam of Pharmaceutical Hungarian language skills required for the pharmaceutical practice.


-

Mid-term exams

-


-

Reading material



- Notes


Lectures

Practices

Seminars


-

Participants

STUDY PROGRAM 2017/2018 Subjects of the 3-4. semesters...

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