STUDY PROGRAM 2021/2022 Elective and Optional Subjects

UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2021/2022

Editing of this publication was closed on July 20, 2021. For the most up-to-date version of course descriptions, please see the subject's web page - in the Education section of the host organizational unit

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University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2021/2022

Elective and Optional Subjects



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Table of Contents

1st semester

OPF-AR1-T __ Art Therapy 1. Basics __________________________________________________________________________ 5

OPF-BBM-T __ Introduction to Biometrics ______________________________________________________________________ 7

OPF-BFM-T __ Problem Solving in Biometrics ___________________________________________________________________ 9

OPF-DME-T __ Cancer is Preventable! ________________________________________________________________________ 11

OPF-GEM-T __ GMO _____________________________________________________________________________________ 13

OPF-H1A-T __ Medical Hungarian 1A - Communication Skills _____________________________________________________ 15

OPF-H1B-T __ Medical Hungarian 1B - Language Points _________________________________________________________ 17

OPF-HCS-T __ If only I knew how to do it... How to study effectively at university? ____________________________________ 19

OPF-N77-T __ English Brush Up Course For Pharmacy Students ___________________________________________________ 21

OPF-NS1-T __ Nobel Prize Awarded Cell Biology I _____________________________________________________________ 23

OPF-OTT-T __ History of Medicine __________________________________________________________________________ 25

OPE-KP1-T __ Basics of Chemistry 1 _________________________________________________________________________ 27

OPE-N06-T __ Medical Terminology _________________________________________________________________________ 29

OPE-SKS-T __ Inorganic Chemistry Calculations _______________________________________________________________ 31

OPE-GOM-T _ Poisonous Mushrooms ________________________________________________________________________ 33

OPE-BFA-T __ Physical Basis of Biophysics ___________________________________________________________________ 35

OPE-HPR-T __ Health Promotion ____________________________________________________________________________ 37

OPE-SP1-T __ Pharmacy Biophysics Seminars 1 ________________________________________________________________ 39

2nd semester

OPF-AR2-T __ Art Therapy 2. Management of Psychosomatic Diseases ______________________________________________ 41

OPF-BMK-T _ Methods and Experiments in Molecular Biology ____________________________________________________ 43

OPF-ETF-T __ Preparation for the Physiology __________________________________________________________________ 45

OPF-FPB-T __ Biological Applications of Fluorescence Polarization Methods _________________________________________ 47

OPF-H2A-T __ Medical Hungarian 2A - Communication Skills _____________________________________________________ 50

OPF-H2B-T __ Medical Hungarian 2B - Language Points _________________________________________________________ 52

OPF-IZM-T __ Molecular Basis of Muscle Function _____________________________________________________________ 54

OPF-MGY-T _ Medicinal Plants in the Mecsek Mountain _________________________________________________________ 56

OPF-N04-T __ Anatomical Terminology ______________________________________________________________________ 58

OPF-NS2-T __ Nobel Prize Awarded Cell Biology II _____________________________________________________________ 60

OPF-PLH-T __ The Placebo Effect ___________________________________________________________________________ 62

OPF-VEO-T __ Vaccination, Anti-Vaccination Movements: Do More Harm than Good __________________________________ 64

OPF-XC1-T __ Extracellular Vesicles: Basics, Isolation and Application Methods 1 _____________________________________ 65

OPE-ABI-T __ Applied Biometrics ___________________________________________________________________________ 68

OPE-FKS-T __ Physical Chemistry Problem Solving Seminar ______________________________________________________ 70

OPE-KP2-T __ Basics of Chemistry 2 _________________________________________________________________________ 72

OPE-QAS-T __ Quantitative Analytical Chemistry Calculation _____________________________________________________ 74

OPE-DRD-T __ Drug Design ________________________________________________________________________________ 76

OPE-ETI-T ___ Pharmacy Ethics _____________________________________________________________________________ 78

OPE-GKT-T __ History of Manufacture of Medicines _____________________________________________________________ 80

OPE-BES-T __ Bioethics Seminar ____________________________________________________________________________ 82

OPE-JEA-T __ Diseases of Signal Transduction _________________________________________________________________ 84

OPE-SP2-T __ Pharmacy Biophysics Seminars 2 ________________________________________________________________ 86



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3rd semester

OPF-CY1-T __ Cybernetics for Medical, Dentistry and Pharmacy Students 1 __________________________________________ 88

OPF-EBK-T __ Food Safety and Crisis Situations ________________________________________________________________ 90

OPF-H3A-T __ Medical Hungarian 3A - Basics of Medical Communication for Students of Pharmacy ______________________ 92

OPF-H3B-T __ Medical Hungarian 3B - Medical Communication in Practice for Students of Pharmacy _____________________ 94

OPF-HB1-T __ How to Achieve Better Grade in Organic Chemistry 1 _______________________________________________ 96

OPF-IPM-T __ Innovation and Project Management from a Business Perspective (KÜLÖN KURZUS!!!) ___________________ 98

OPF-MGE-T __ Molecular Gerontology_______________________________________________________________________ 100

OPF-SNA-T __ Carbon Nanostructures _______________________________________________________________________ 102

OPF-SSG-T __ Histology Seminar for Pharmacy Students ________________________________________________________ 104

OPF-TG1-T __ Student Project Research for Students of Pharmaceutist Programme 1 __________________________________ 106

OPF-TMB-T __ Molecular Biology of Tumors _________________________________________________________________ 107

OPE-DM1-T __ Demonstrator Activity 1 ______________________________________________________________________ 109

OPE-WMI-T __ Weak Molecular Interactions __________________________________________________________________ 110

OPE-TSS-T __ Medical Applications of Mass Spectrometry ______________________________________________________ 113

OPE-BEE-T __ Basics of Epidemiology ______________________________________________________________________ 115

OPE-EHS-T __ Hunger, Satiety and Disturbances of Body Weight Regulation ________________________________________ 117

OPE-HL1-T __ Advanced physiology 1 ______________________________________________________________________ 119

4th semester

OPF-CME-T __ Computational Molecular Engineering ___________________________________________________________ 121

OPF-CY2-T __ Cybernetics for Medical, Dentistry and Pharmacy Students 2 _________________________________________ 123

OPF-CSU-T __ Miracles of Living Materials ("Realistic" Biochemistry) _____________________________________________ 125

OPF-DR2-T __ Drug Design 2 _____________________________________________________________________________ 127

OPF-ESP-T __ Exercise and Sport Physiology _________________________________________________________________ 129

OPF-GMI-T __ Daily Routine and Challenges in Various Fields of the Pharmacy Profession _____________________________ 131

OPF-H4A-T __ Medical Hungarian 4A - Basics of Medical Communication for Students of Pharmacy _____________________ 133

OPF-H4B-T __ Medical Hungarian 4B - Medical Communication in Practice for Students of Pharmacy ____________________ 135

OPF-HB2-T __ How to Achieve Better Grade in Organic Chemistry 2 ______________________________________________ 137

OPF-HFG-T __ Great Discoveries in Pharmacology _____________________________________________________________ 139

OPF-QBI-T __ Quantum Biology: Quantum Phenomena in Biological Processes ______________________________________ 141

OPF-SKI-T ___ Basics of Chemical Informatics ________________________________________________________________ 144

OPF-TG2-T __ Student Project Research for Students of Pharmaceutist Programme 2 __________________________________ 146

OPF-VAN-T __ Iron Metabolism: from Molecular Mechanisms to Clinical Consequences _______________________________ 147

OPE-BKM-T _ Basic Methods of Scientific Research ___________________________________________________________ 149


OPE-GMO-T _ Modelling the Structure and Interactions of Bioactive Molecules ______________________________________ 153

OPE-SME-T __ Spectrometric Identification of Organic Compounds ________________________________________________ 156

OPE-HL2-T __ Advanced Physiology 2 ______________________________________________________________________ 158

OPE-TIZ-T ___ Central Regulation of Feeding and Metabolism. New Approaches _____________________________________ 160

5th semester

ATT5-T _____ Physical Education 5 ________________________________________________________________________ 162

OPF-GKG-T __ Gas Chromatography ________________________________________________________________________ 163

OPF-GLK-T __ Bioinorganic Chemistry for Pharmacy Students ____________________________________________________ 165

OPF-GMT-T __ Drug Metabolism and Drug Toxicity ____________________________________________________________ 167

OPF-HKG-T __ Interfacial Chemistry in Pharmaceutical Technology ________________________________________________ 169

OPF-HVS-T __ Synthesis of Heterocyclic Compounds and Their Application in Therapy ________________________________ 171



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OPF-MEM-T _ Health Benefits of Honey and Other Bee Products __________________________________________________ 174

OPF-TS1-T __ Calculations in Pharmaceutical Technology 1 _____________________________________________________ 176

OPF-VGG-T __ Collecting and Conservation of Wild Native Medicinal Plants ________________________________________ 178

OPE-EFA-T __ Ethnopharmacobotany _______________________________________________________________________ 180

OPE-FAO-T __ Applied Health Economics ____________________________________________________________________ 182

OPE-TG3-T __ Student Project Research for Students of Pharmaceutist Programme 3 __________________________________ 184


6th semester

OPF-DTS-T __ The Role of Drug Transporters _________________________________________________________________ 186

OPF-NSG-T __ Plant Products in the Pharmaceutical Practice _____________________________________________________ 189

OPF-TS2-T __ Calculations in Pharmaceutical Technology 2 _____________________________________________________ 191

OPE-STK-T __ Basics of Stereochemistry ____________________________________________________________________ 193

OPE-GFK-T __ Physico-Chemical Bases of Drug Action _________________________________________________________ 195

OPE-TG4-T __ Student Project Research for Students of Pharmaceutist Programme 4 __________________________________ 197

OPE-VFM-T __ Business Development and Management _________________________________________________________ 198

OPE-ASZ-T __ The Antimicrobial Drugs and their Clinical Use ___________________________________________________ 200


OPE-KPR-T __ Chemoprevention ___________________________________________________________________________ 203

7th semester

OPF-FEA-T __ Basics of Infectious Disease Epidemiology _______________________________________________________ 205

OPF-KIA-T __ Essential Oils and Clinical Aromatherapy ________________________________________________________ 207

OPE-FMA-T __ Data Analysis 1 ____________________________________________________________________________ 209

OPE-FM2-T __ Data Analysis 2 ____________________________________________________________________________ 211


OPE-OPM-T __ Online Pharmaceutical Market and the Dangers of Counterfeit Medicines _______________________________ 214

OPE-SHK-T __ Design and Industrial Manufacture of Medicines ___________________________________________________ 216

8th semester

OPF-GTH-T __ Gene Therapy ______________________________________________________________________________ 218


OPE-DRO-T __ Drug and Substance Abuse ____________________________________________________________________ 221

OPE-FAJ-T __ Pain and Analgesics _________________________________________________________________________ 223

OPE-MGT-T _ Pharmaceutical Technology of Modified Drug Release ______________________________________________ 225

OPE-IVF-T __ Infections and Immunity ______________________________________________________________________ 227

9th semester

OPF-SUO-T __ Emergency Medicine ________________________________________________________________________ 229


OPE-GST-T __ Special Fields of Pharmacology ________________________________________________________________ 232



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OPF-AR1-T ART THERAPY 1. BASICS

Course director: DR. TAMÁS OLLMANN, assistant professor

Institute of Physiology [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 6 lectures + 0 practices + 6 seminars = total of 12 hours

Course headcount limitations (min.-max.): 3 – 50 Prerequisites: -

Topic

Art therapy is based on the idea that the traumatic experience may not be accessible verbally but instead is locked in a subconscious

form. Metaphoric cues employed in art methods allow the delicate, ecological transformation of unpleasant experience into conscious

knowledge, and turn the emotional or physical pain into a resource. Basic knowledge of art-therapeutical methods will replenish the

repertoire of the students with multiple techniques for assistance (to self and others) in critical situations, including state of disease, with

the use of creative tools. The course contributes to a better understanding of the psychological aspects of diseases, their causes,

management, and prevention. Improvement of awareness in relationships and lifestyle, work with self-esteem, development of creative

thinking and problem solving, training of focusing, generalization, and isolation of the main ideas, improvement of verbal and fine motor

skills,- are the few additional assets of the course which might be beneficial for the future physicians. The methods are designed for

persons with ordinary creative skills, thus do not require special equipment or abilities. Students can expect informative and well-

structured lectures followed by dynamic, interactive seminar classes. Topics of the first semester cover the basic principles and the main

branches of art therapy.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Completed practical tasks, written test.

Making up for missed classes

Presentation on topic.

Reading material

- Obligatory literature

- Literature developed by the Department

The slides will be available.

- Notes

- Recommended literature

Lectures

1 Introduction to art therapy (AT). Basic terms, functions, principles of AT.

Zagorácz Olga

2 Plastic materials in AT.

Zagorácz Olga

3 Texts and associative cards in AT.

Zagorácz Olga

4 Phototherapy and collaging in AT.

Zagorácz Olga

5 Textile-therapy, the essence of ancient and innovative techniques.

Zagorácz Olga

6 Innovative methods of AT.

Zagorácz Olga

Practices

Seminars

1 Fine art as AT instrument.

Zagorácz Olga

2 Plasticine, dough, clay as AT instruments.

Zagorácz Olga

3 Storytelling, writing in AT.

Zagorácz Olga



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4 Practices with images in AT.

Zagorácz Olga

5 Practices with textile, creation of dolls.

Zagorácz Olga

6 Art-coaching.

Zagorácz Olga

Exam topics/questions

The topics of the lectures.

Participants

Zagorácz Olga (J5ZJ9T)



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OPF-BBM-T INTRODUCTION TO BIOMETRICS

Course director: DR. LÁSZLÓ PÓTÓ, associate professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1



Topic

Exploring data (using graphs and numbers) are usually handled as one-lesson / first chapter by basic statistical courses. This is, because

a first course in statistics introduces many new skills. It also introduces some new ideas, that all are hard to understand for students. The

new approach is to make a solid foundation to learn statistics by a more thorough introduction to those: The course tries to make clear a

few of these fundamental ideas of statistics - limited to understanding and working with data. An improved skill for exploring data is

useful not only at your classes and your future job but in the everyday life as well.


Maximum one missed class.

Mid-term exams

Active participation at the classes.


One extra class

Reading material



- Notes

László Pótó: Biometrics, workbook, Pécs, 2020


1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005 and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.

Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 Probability examples 1

Dr. Pótó László

2 Probability examples 1

Dr. Pótó László

3 Probability examples 2 - discrete distributions

Dr. Pótó László

4 Probability examples 2 - discrete distributions

Dr. Pótó László

5 Exploring data by graphs

Dr. Pótó László

6 Exploring data by graphs

Dr. Pótó László

7 Exploring data by numbers - sample measures

Dr. Pótó László

8 Exploring data by numbers - sample measures

Dr. Pótó László

9 The normal distribution

Dr. Pótó László

10 The normal distribution

Dr. Pótó László



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11 Distribution of the mean; Stat estimation: the CI for the expected value

Dr. Pótó László

12 Distribution of the mean; Stat estimation: the CI for the expected value

Dr. Pótó László

Seminars


No exam - but active participation on the classes is a must.

Participants

Dr. Pótó László (FIO4UU)



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OPF-BFM-T PROBLEM SOLVING IN BIOMETRICS






Topic

Give a chance to have more practice to solve problems in Biometrics using PC and the SPSS software in the computer room. This was a

regular need of the students earlier since the special way how a MD should handle the typical medical problems (special way of thinking)

was not founded by the secondary school education. This foundation is an important focus point of the Biometrics course. It seems, the

weekly 1+1 lectures were not enough for most of the students for completing this important goal: To develop some brand new skills.

This course offers an organized way for that extra practices. It offers also some ‘brushing up’ chances for those who has completed

Biometrics earlier.


Maximum one missed class

Mid-term exams

Active participation on the classes.


One extra class

Reading material



- Notes

László Pótó: Biometrics, workbook, Pécs, 2020.


1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015. or

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005 and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.

Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 The one sample (and the paired samples) t test

Dr. Pótó László

2 The one sample (and the paired samples) t test

Dr. Pótó László

3 The CI and the hypothesis testing - the type one and type two errors.

Dr. Pótó László

4 The CI and the hypothesis testing - the type one and type two errors. MDM basics 1.

Dr. Pótó László

5 The independent samples t test

Dr. Pótó László

6 The independent samples t test

Dr. Pótó László

7 The linear regression

Dr. Pótó László

8 The linear regression

Dr. Pótó László

9 The contingency tables - the chi squares test

Dr. Pótó László

10 The contingency tables - the chi squares test. MDM-1/2



10

Dr. Pótó László

11 The nonparametric tests

Dr. Pótó László

12 The nonparametric tests. MDM basics 2.

Dr. Pótó László

Seminars


No exam but active participation on the classes is a must.

Participants




11

OPF-DME-T CANCER IS PREVENTABLE!

Course director: DR. ISTVÁN ZOLTÁN KISS, professor

Department of Public Health Medicine [email protected]




Topic

One of the major challenges for the health care system of the 21st century is the high number of cancer caused deaths. Over the past

decades, despite a significant development on the field of medicine, the prognosis of this disease is still not satisfactory. Thus prevention

has a key role in in the fight against cancer. The course gives a description on the different types of cancer their major risk factors for a

more detailed understanding. Methods of cancer prevention will be described and emphasized - including theoretical knowledge and a

practical guide as well. During the course the results of most recent human epidemiological studies on cancer will also be described.


Participation in lectures and practicals is obligatory which is registered. Absences should not exceed 4x45 min. Otherwise signature of

grade book is denied.

Mid-term exams


There are no make-up classes.

Reading material



Educational material uploaded on Neptun.

- Notes


Robert Weinberg (ed.): The Biology of Cancer, Garland Science 2006 ISBN 0815340788

Boffetta P., La Veccia: Neoplasms 2009. In Detels R, Beaglehole R, Lansang MA and Gulliford M (eds.) Oxford Textbook of Public

Health, 5th ed., Oxfort University Press

Lectures

1 Cancer in the 21st century

Dr. Kiss István Zoltán

2 Cancer in developing and developed countries


3 The process of carcinogenesis I.


4 The process of carcinogenesis II.


5 Characteristics of cancer cells


6 Molecular epidemiology of cancer


7 The most important cancer risk factors in general I.


8 The most important cancer risk factors in general II.


9 Lung cancer


10 Colorectal tumors I.


11 Colorectal tumors II.


12 Breast cancer


13 Prostate cancer



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14 Head and neck cancer


15 Pancreatic cancer


16 Gastric cancer


17 Liver cancer


18 Cervical cancer


19 Ovarian cancer


20 Skin cancer


21 Leukemia


22 Less frequent tumors


Practices

1 Genetics, genomics and epigenetics in cancer prevention


2 Cancer prevention - Recommendations


Seminars


Neptun

Participants

Dr. Kiss István Zoltán (EFZCGE)



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OPF-GEM-T GMO

Course director: DR. ZOLTÁN GYÖNGYI, senior research fellow





Topic

The application of genetically modified organisms (GMOs) gains more and more ground in food industry. Over the direct health effect,

they have an impact on human economy, health and environment. The topic provokes social debate, in which, in lack of information,

delusions also appear. The tecnology is also used in industry, science and human therapy. During the education, students receive a

knowledge of molecular background of production GMOs, their possible health risks, their occurrence in foodstuffs, medical applications,

detection, regulations, authorization, economical and social impacts.



Mid-term exams

Providing a new date after individual consultation.


none

Reading material



Slides on the Neptun

- Notes


Lectures

1 Definition of GMO

Dr. Gyöngyi Zoltán

2 Needs of GMOs in different disciplines


3 The development of agriculture to GMOs


4 The role of GMOs in crop production


5 The role of GMOs in animal breeding


6 Impact of GM crops on natural habitats and organic farming


7 GMO production. History of science


8 GMO production. Description of biotechnology methods


9 GMO detection methods


10 Occurrence of GM organisms in food, their detectability


11 GMO in industry


12 GMO in the pharmaceutical industry


13 GMO in science




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14 GMO and disease prevention


15 GMO and therapy


16 The past, present and future of gene therapy


17 Genetic modification of humans


18 Potential health effects of GMOs


19 Background of deaths caused by GMOs


20 Preventing the harmful effects of GMOs


21 Authorization procedures of GMOs


22 GMO production for commercial use


23 The economic impact of GMOs


24 Social debates, publicity


Practices

Seminars


A GMO fogalma

A GMO megjelenésének igénye különböző tudományterületeken

A mezőgazdaság fejlődése a GMO megjelenéséig

A GM szervezetek szerepe a növénytermesztésben

A GM szervezetek szerepe az állattenyésztésben

A GM növények hatása természetes élőhelyekre és a biogazdálkodásra

GMO előállítás. Tudománytörténeti áttekintés

GMO előállítás. Biotechnológiai módszerek ismertetése

GMO kimutatási módszerek

A GM szervezetek élelmiszerekben való előfordulása, kimutathatóságuk

GMO az iparban

GMO a gyógyszeriparban

GMO a tudományban

GMO és a betegségmegelőzés

GMO és a gyógyítás

A génterápia múltja, jelene és jövője

Az ember genetikai módosítása

A GM szervezetek lehetséges egészségkárosító hatásai

GM szervezetek okozta halálesetek háttere

A GM szervezetek egészségkárosító hatásának kivédése

A GM szervezetek engedélyezésének feltételei

Kereskedelmi GMO előállítás

A GM szervezetek gazdasági hatása

Társadalmi viták, tájékoztatás

Participants



15

OPF-H1A-T MEDICAL HUNGARIAN 1A - COMMUNICATION SKILLS

Course director: DR. VILMOS WARTA, associate professor

Department of Languages for Specific Purposes [email protected]



Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1B-T parallel

Topic

To establish basic skills in reading, writing, listening and speaking Hungarian in preparation for effective medical communication.



Mid-term exams

Written midterm and end of the term tests are compulsory. Other short written tests to be discussed with the course tutor in each individual

case. Several oral tests are taken, dates are to be discussed with the course tutor. Make up tests possible only during the semester classes.


Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In

the case of absences up to 25% of total class time, oral examination will have to be taken

Reading material


Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs


In-house course book: at the homepage of the institute:

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Notes





Lectures

Practices

Seminars

1 Greeting people, formality and informality

2 Greeting people, formality and informality

3 Addressing people, men and women

4 Addressing people, men and women

5 Starting conversation, the elderly and children

6 Starting conversation, the elderly and children

7 Introducing, equal and unequal relations

8 Introducing, equal and unequal relations

9 Nutritional History Taking

10 Nutrients

11 Nutrients

12 Test 1

13 Health Preservation, Sports, Addictions

14 Writing CV, occupation, work

15 Medical Specialties, Consulting Room and Ward

16 Telling CV, family relations

17 Introducing family

18 Introducing family

19 Describing people - Internal and external features






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20 Describing people - Internal and external features

21 Health care institutions, consolidation

22 Test 2

23 Evaluation

24 Evaluation


Two written test papers and oral presentation topics to be discussed with the course tutor in each individual case.

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (JR0PVR), Ronczykné Berta Anikó (CJZOFU), Szalai-

Szolcsányi Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)



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OPF-H1B-T MEDICAL HUNGARIAN 1B - LANGUAGE POINTS





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1A-T parallel

Topic

Familiarizing foreign students with basic paradigms used in specific conversations.



Mid-term exams

Written midterm and end of the term tests are compulsory. Other short written tests to be discussed with the course tutor in each individual

case. Several oral tests are taken, dates are to be discussed with the course tutor. Make up tests possible only during the semester classes.


Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In

the case of absences up to 25% of total class time, oral examination will have to be taken

Reading material





- Notes





Lectures

Practices

Seminars

1 Basics of Hungarian Phonetics and Morphology

2 Basics of Hungarian Phonetics and Morphology

3 Personal Pronouns - formal and informal style

4 Personal Pronouns - formal and informal style

5 Constructing Questions - Question Words

6 Constructing Questions - Question Words

7 Numerals - Cardinal, Ordinal, Labels

8 Numerals - Cardinal, Ordinal, Labels

9 Verbs - Definite and Indefinite Conjugation

10 Verbs - Definite and Indefinite Conjugation

11 Expressing Frequency

12 Expressing Frequency

13 Test 1

14 Articles

15 Modality - necessity

16 Modality - necessity

17 Objective Case

18 Verbal prefixes

19 Expressing Time

20 Expressing Time

21 Expressing Location - Trinity of Directions






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22 Dative Case

23 Test 2

24 Course Evaluation



Participants








19

OPF-HCS-T IF ONLY I KNEW HOW TO DO IT... HOW TO STUDY EFFECTIVELY AT UNIVERSITY?

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy [email protected]




Topic

The course introduces students to study techniques and approaches that can be used effectively in studying any subject and passing exams

at the university. Classes will include developing study skills and attitudes through interactive tasks to enhance focusing, reading,

comprehension, grasping the main points, memorizing and logical thinking. Students will analyze their own studying customs and

strategies, and will be guided through changing these habits if necessary, in order to study more effectively and willingly. After providing

some theoretical background in the lectures, students can put into practice each technique in the seminars.



Mid-term exams

Mastering the theoretical background and implementing the course material into practice will be checked by individual tasks and team

work during classes, as well as home assignments.


Students can make up for missed classes by completing assignments at home or by presenting a topic related to the course.

Reading material



Lecture materials and seminar handouts will be available in Neptun Meet Street.

- Notes


Marty Lobdell (2015): Study Less, Study Smart.

Lectures

1 General characteristics of university studies. Types of classes, assignments, exams.

Dr. Farkas Ágnes

2 Know yourself: motivation to study

Dr. Farkas Ágnes

3 Know yourself: styles of studying

Dr. Farkas Ágnes

4 Know yourself: strategies of studying

Dr. Farkas Ágnes

5 Study techniques: reading

Dr. Farkas Ágnes

6 Study techniques: studying from a textbook

Dr. Farkas Ágnes

7 Study techniques: taking notes, preparing an outline

Dr. Farkas Ágnes

8 Study sources: using a library

Dr. Farkas Ágnes

9 Study sources: using the internet

Dr. Farkas Ágnes

10 Test writing, question types

Dr. Farkas Ágnes

11 Preparing for exams, passing an exam

Dr. Farkas Ágnes

12 Presentations

Dr. Farkas Ágnes



20

13 Manage your study customs: optimal outer and inner conditions

Dr. Farkas Ágnes

14 Manage your study customs: time management

Dr. Farkas Ágnes

Practices

Seminars

1 Motivation inventory

Pap Ramóna

2 Diagnosis of style of studying

Pap Ramóna

3 Reading comprehension practices

Pap Ramóna

4 Practices for focusing your attention

Pap Ramóna

5 Image memories - memory images

Pap Ramóna

6 Concentration practices

Pap Ramóna

7 Problem solving tasks

Pap Ramóna

8 Logical tasks developing combinatory skills

Pap Ramóna

9 Developing peripheral vision

Pap Ramóna

10 Increasing the width of visual fixation

Pap Ramóna

11 Rhythmic eye movements

Pap Ramóna

12 Practice to observe and increase awareness of study customs

Pap Ramóna

13 Implementing new study customs

Pap Ramóna

14 Summarizing experiences, feedback

Pap Ramóna


1. General characteristics of university studies. Types of classes, assignments, exams.

2. Know yourself: motivation to study

3. Know yourself: styles of studying

4. Know yourself: strategies of studying

5. Study techniques: reading

6. Study techniques: studying from a textbook

7. Study techniques: taking notes, preparing an outline

8. Study sources: using a library

9. Study sources: using the internet

10. Test writing, question types

11. Preparing for exams, passing an exam

12. Presentations

13. Manage your study customs: optimal outer and inner conditions

14. Manage your study customs: time management

Participants

Pap Ramóna (OGEM0W)



21

OPF-N77-T ENGLISH BRUSH UP COURSE FOR PHARMACY STUDENTS






Topic

The Faculty of Pharmacy and the Department of Languages for Biomedical Purposes and Communication provides an opportunity for

pharmacy students to brush up their Academic English written and oral skills in 24 contact hours.



Mid-term exams

Two written test papers:

Week 6: Test 1; Week 12: Test 2.


To be discussed with the course tutor.

Reading material



In-house materials

- Notes


Lectures

Practices

Seminars

1 Review of verb tenses

Dr. Warta Vilmos


Dr. Warta Vilmos


Dr. Warta Vilmos


Dr. Warta Vilmos


Dr. Warta Vilmos


Dr. Warta Vilmos

7 Impersonalisation

Dr. Warta Vilmos

8 Impersonalisation

Dr. Warta Vilmos

9 Impersonalisation

Dr. Warta Vilmos

10 Impersonalisation

Dr. Warta Vilmos

11 Written Test 1

Dr. Warta Vilmos

12 Written Test 1

Dr. Warta Vilmos

13 Modality and politeness strategies

Dr. Warta Vilmos



22


Dr. Warta Vilmos


Dr. Warta Vilmos


Dr. Warta Vilmos


Dr. Warta Vilmos


Dr. Warta Vilmos

19 Nominalisation

Dr. Warta Vilmos

20 Nominalisation

Dr. Warta Vilmos

21 Nominalisation

Dr. Warta Vilmos

22 Nominalisation

Dr. Warta Vilmos

23 Written Test 2

Dr. Warta Vilmos

24 Written Test 2

Dr. Warta Vilmos


Participants

Dr. Németh Tímea (X8VRGN), Dr. Warta Vilmos (SJYRAV), Nagy Renáta (JR0PVR), Szántóné Dr. Csongor Alexandra (UDKY0J)



23

OPF-NS1-T NOBEL PRIZE AWARDED CELL BIOLOGY I

Course director: DR. MARIANNA PAP, associate professor

Department of Medical Biology and Central Electron Microscope Laboratory [email protected]




Topic

The aim of the course is to present the most important and most exciting Nobel Prize-winning molecular cell biology discoveries based

on Nobel lectures given by the winners. The background story of the awards reveals many years of research work, good ideas, good

fortune mixed with family and other personal memories. There is no single recipe for success, the road is always a bit different, and

perhaps the only common feature is the teamwork. From the presentations one might get insight of the winners” personality as well. An

important aspect was in the selection of the topics to emphasize their significance (DNA-, RNA-structure and their synthesis, ribosome

function), their impact on current medical way of thinking (e.g. Prions) and diagnostic methods (e.g. recombinant DNA technology,

DNA sequencing), the description of their present and future medical applicability (e.g. in vitro fertilization), as well as to highlight their

potential relations to different diseases (e.g. cell cycle regulation, reprogram of differentiated cells, RNA interference, papillomaviruses,

HIV). Lectures are organized based on the topics related to the weekly schedule of the molecular cell biology course, not in chronological

order. Most of the presented discoveries and experiments are involved in the molecular cell biology course material, so hopefully their

discussion helps in the better understanding of those topics and lead to a more effective and shorter exam preparation.



Mid-term exams

2 written tests: on week 7 and on week 14.


Participation on Hungarian or German lectures is the only possibility to make-up missed lectures.

Reading material



- Notes


www.nobelprize.org

Lectures

1 Life of Alfred Nobel

Dr. Pap Marianna

2 History of Nobel prize, interesting facts

Dr. Pap Marianna

3 Structure of proteins

Dr. Pap Marianna

4 Prions

Dr. Pap Marianna

5 Structure of nucleic acids, catalytic RNA molecules

Dr. Pap Marianna

6 Recombinant DNA technology

Dr. Pap Marianna

7 PCR

Dr. Pap Marianna

8 DNA sequencing

Dr. Pap Marianna

9 Inhibition of gene expression (KO mutation)

Dr. Pap Marianna

10 Inhibition of gene expression (RNA interference)

Dr. Pap Marianna

11 Regulation of cell cycle

http://www.nobelprize.org/



24

Dr. Pap Marianna

12 Regulation of cell cycle

Dr. Pap Marianna

13 DNA replication

Dr. Pap Marianna

14 DNA repair

Dr. Pap Marianna

15 Eukaryotic RNA synthesis

Dr. Pap Marianna

16 Splicing

Dr. Pap Marianna

17 Structure and function of ribosomes

Dr. Pap Marianna

18 Role of RNA molecules in translation, Genetic code

Dr. Pap Marianna

19 Gene regulation in prokaryotic cells

Dr. Pap Marianna

20 Gene regulation in eukaryotic cells

Dr. Pap Marianna

21 Rough endoplasmic reticulum, vesicular transport

Dr. Pap Marianna

22 Receptor-mediated endocytosis

Dr. Pap Marianna

23 Exam

Dr. Pap Marianna

24 Exam

Dr. Pap Marianna

Practices

Seminars


.

Participants



25

OPF-OTT-T HISTORY OF MEDICINE

Course director: DR. TAMÁS MOLNÁR F., professor

Department of Operational Medicine [email protected]




Topic

The purpose of the course is to give an opportunity for reviewing the progress in medicine historically, from the ancient times up to the

present époque, on the basis of cultural background. The understanding of the fact that contemporary medicine is the result of the efforts

of several centuries will be hopefully stimulatory for the students in the professional improvement, realizing that both the theoretical

basis and healing practice are due to the devoted work of previous generations. Accordingly, the progress from healing art to healing

science will be illustrated in relation to the culture of previous centuries.


Survey of the theoretical basis of medical practice in a historical period.

Mid-term exams


Reading material



Summary of the content of each lecture (detailed description of authors and the main outlines of their activity promoting the medicine)

- Notes


Delano: The Story of Medicine, London

Benke J.: Az orvostudomány története - Hungarian ed. with English summary, Medicina, Bp. 2008.

Lectures

1 History of Medicine – WHY?

Dr. Molnár F. Tamás

2 History of Medicine – WHY?


3 Structure of lectures – groups


4 Structure of lectures – groups


5 Ancient - Stone Age / Egypt- India


6 Ancient - Greeks - Hyppocrates


7 Ancient - Romans - Galenus


8 Ancient - Mythology and diseases


9 Middle age - Cloisters and Monks


10 Middle age - Arabs – India / China / America


11 Middle age - Surgeons & Medications


12 Middle age - Renessaince: anatomy and medicine


13 Middle age - Enlightement: Science and medicine


14 Romantic Medicine: 19th Century



26


15 Germs and Miazmas: age of bacteriology


16 Medicine and Surgery: WW1


17 Century of Surgery and Images


18 Medicine and Surgery: WW2


19 Medicine till the New Milleneum and beyond


20 Special topics: Plagues from Athen to COVID-19


21 Special topics: Medicines from the nicotin to the target therapy


22 Special topics. syndromes, names, ancestors


23 Q&A, Course closing


24 Q&A, Course closing


Practices

Seminars


Essay regarding any topic related to the theme of the lectures.

Participants



27

OPE-KP1-T BASICS OF CHEMISTRY 1

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1



Topic

The course provides an overview of the basic laws of Chemistry concentrating on those that are ubiquitous in the chemistry-related

subjects of the basic modules of the health-related curriculums. The course helps understanding the chemistry-related compulsory

subjects of the modules.


The course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory. Maximum three absences

can be accepted both from lectures and practices.

Two written will be written during the semester. The result of one of them should be at least 60%, the average of the two should be at

least 50%. The result of the improving test is combined with those of the two midterm tests.

Mid-term exams

Two written will be written during the semester. The result of one of them should be at least 60%, the average of the two should be at

least 50%. The result of the improving test is combined with those of the two midterm tests


There is no opportunity to make up missed classes.

Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational

material, University of Pécs, 2014

- Notes


en.wikibooks.org/wiki/General_Chemistry

Lectures

1 The electronic structure of atom. Elements.

Dr. Perjési Pál

2 The electronic structure of atom. Elements.

Dr. Perjési Pál

3 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

4 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

5 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

6 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

7 Liquids and solutions. Concentrations.

Dr. Perjési Pál

8 Liquids and solutions. Concentrations.

Dr. Perjési Pál

9 Colligative properties.

Dr. Perjési Pál

10 Colligative properties.

Dr. Perjési Pál

11 Chemical thermodynamics I.

Dr. Perjési Pál




28

12 Chemical thermodynamics I.

Dr. Perjési Pál

13 Chemical kinetics.

Dr. Perjési Pál

14 Chemical kinetics.

Dr. Perjési Pál

15 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

16 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

17 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

18 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

19 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

20 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

21 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

22 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

23 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

24 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

25 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

26 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

27 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

28 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

Practices

Seminars


Written tests covering the topics of the lectures.

Participants

Dr. Perjési Pál (F4H45V)



29

OPE-N06-T MEDICAL TERMINOLOGY

Course director: DR. KATALIN EKLICS-LEPENYE, assistant professor





Topic

Introduction into the basics of Medical Terminology pertaining to anatomical and clinical aspects focusing on word building and breaking

down medical terms.



Mid-term exams

A midterm test during week 6.

End-of-term test during week 12.


To be discussed with the instructor.

Reading material



- Notes


University Script

Donáth, Tibor: Lexicon Anatomiae. Anatomical Dictionary, Semmelweis, Bp. 1999

Jean Tannis Dennerll: Medical Terminology Made Easy, Delmar Publishers Inc., New York 1991

Lectures

1 Introduction into Medical Terminology. The importance of Medical terminology in practice.

Eklicsné Dr. Lepenye Katalin

2 Terminology of diseases and diagnosis.


3 Body structure. Anatomical directions, body planes.


4 Anatomical terminology of he skeletal system and the skull.


5 Terminology of continuous and discontinuous connections and the muscular system.


6 Terminology of the cardiovascular system and the heart.


7 Terminology of the respiratory system.


8 Terminology of the digestive system.


9 Terminology of the urinary system.


10 Terminology of the male reproductive system.


11 Terminology of the female reproductive system.


12 Terminology of the sensory organs.




30

Practices

Seminars

1 Structure of Medical Terminology. Prefixes, suffixes, word roots. Introduction to clinical terminology.

2 Terminology of diseases.

3 Terminology of diagnosis.

4 Body structure. Anatomical directions, orientation; body planes.

5 Bones of the human body. Terminology of the skeletal system.

6 Mid-term test

7 Terminology of the muscular system.

8 Terminology of the heart and cardiovascular system.

9 Terminology of the respiratory system.

10 Terminology of the digestive system.

11 Revision

12 End-of-term test


Anatomical and clinical terminology of the locomotor, cardiovascular, respiratory and digestive systems.

Participants

Eklicsné Dr. Lepenye Katalin (JMXXSC), Nagy Renáta (JR0PVR), Ronczykné Berta Anikó (CJZOFU)



31

OPE-SKS-T INORGANIC CHEMISTRY CALCULATIONS

Course director: DR. ZSUZSANNA ROZMER, assistant professor





Topic

This subject is based on the acquired theoretical knowledge on General and Inorganic Chemistry, with adaptation of the principles to

solve chemical problems. The aim of this course to solve chemical calculations related to the lessons of General and Inorganic Chemistry

1 and give a support for easier understanding of the subject.


According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of both tests should be above

60%. One re-take chance is allowed.

Mid-term exams

Two written exams during the semester.



Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009.


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Calculations, electronic educational

material, University of Pécs, 2014

- Notes



Lectures

Practices

Seminars

1 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.

Dr. Rozmer Zsuzsanna

2 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.


3 Stochiometric calculations. Calculation of concentrations.


4 Stochiometric calculations. Calculation of concentrations.


5 Calculation of concentrations, Solubility.


6 Calculation of concentrations, Solubility.


7 Electrolytic dissociation.


8 Electrolytic dissociation.


9 Kolligative properites.


10 Kolligative properites.





32

11 Thermochemistry (Hess’ Law).


12 Thermochemistry (Hess’ Law).


13 Chemical kinetics. Test 1


14 Chemical kinetics. Test 1


15 pH calculations I.: Hydrolysis of salts.


16 pH calculations I.: Hydrolysis of salts.


17 pH calculations II: Buffers.


18 pH calculations II: Buffers.


19 Solubility equilibria.


20 Solubility equilibria.


21 Calculations based on the balancing of redox equations I


22 Calculations based on the balancing of redox equations I


23 Calculations based on the balancing of redox equations II


24 Calculations based on the balancing of redox equations II


25 Calculations on electrochemistry I. Test 2


26 Calculations on electrochemistry I. Test 2


27 Calculations on electrochemistry II


28 Calculations on electrochemistry II



The final grade is established based on the average of each written exams.

Participants

Dr. Kenari Fatemeh (PLZ1CG), Dr. Mészáros Petra (C705FN), Dr. Rozmer Zsuzsanna (IIDYH7), Dr. Tyukodi Levente (IWJHJA),

Fülöpné Kiss Edit (ZBUTWT)



33

OPE-GOM-T POISONOUS MUSHROOMS

Course director: DR. LORÁND BARTHÓ, professor

Department of Pharmacology and Pharmacotherapy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the medical-biological module ▪ autumn semester ▪ recommended semester: 1



Topic

Family physicians may play an important role in the early identification and management of mushroom poisoning (MP).

This course:

- deals with the various types of MP and their symptoms;

- molecular mechanisms encountered with the effects of cytotoxic MPs

- morphological features of the most important toxic mushrooms/fungi and their edible counterparts.


- Attending at least 75% of the lessons, passing the oral exam

- Oral exam includes matters of poisonings, as well as recognizing the most important PMs and their edible counterparts

Mid-term exams

Exam on week 12


Individual

Reading material


--


CD prepared by Prof. Barthó

Most terms will be explained in the lectures.

- Notes

--


--

Lectures

1 Introduction

Dr. Barthó Loránd

2 Amanitas, Lepiotas (parasols) and their poisonings

Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd

6 Other mushrooms with white spores and their poisonings

Dr. Barthó Loránd

7 Other mushrooms with white spores and their poisonings

Dr. Barthó Loránd

8 Mushrooms with pink, brown or black spores

Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd



34

11 Mushrooms with tubes, pores, wrinkles or spines

Dr. Barthó Loránd

12 Mushrooms with tubes, pores, wrinkles or spines

Dr. Barthó Loránd

13 Molecular mechanisms encountered with the effects of cytotoxic MPs

Dr. Szeberényi József

14 Molecular mechanisms encountered with the effects of cytotoxic MPs

Dr. Szeberényi József

15 Morels, false morels, puff-balls, corals, etc. Pre-exam

Dr. Barthó Loránd

16 Morels, false morels, puff-balls, corals, etc. Pre-exam

Dr. Barthó Loránd

17 Some forensic aspects of MPs

Dr. Barthó Loránd

18 Muscarine, muscimol, ibotenic acid

Dr. Barthó Loránd

19 Coprin, orellanin, aflatoxin

Dr. Barthó Loránd

20 Reprise of poisonous mushrooms

Dr. Barthó Loránd

21 Toxins of moulds

Dr. Barthó Loránd

22 Tasks of GP sin case of MP

Dr. Barthó Loránd

23 Reprise of types of poisoning; Exam

Dr. Barthó Loránd

24 Exam

Dr. Barthó Loránd

Practices

Seminars


Oral exam including matters of poisonings, as well as recognizing the most important PMs and their edible counterparts

Cytotoxic MPs

Gastrointestinal MP

Muscarine-type of MP

Psychotropic MP

Other types of MP

Tasks of the general practitioner in case of MP

Participants



35

OPE-BFA-T PHYSICAL BASIS OF BIOPHYSICS

Course director: DR. EMŐKE BÓDIS, assistant professor

Department of Biophysics [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the medical-biological module ▪ both semesters ▪ recommended semester: 1



Topic

The course addresses the chapters of physics which are necessary for a proper understanding of Biophysics (lecture and practicals).

Beyond theoretical discussions, example problems are solved.



Mid-term exams

No midterm exam.


There is no option.

Reading material



- Notes

Course related information can be found on the website of PotePedia.


As a base, any secondary school physics book is useful.

Lectures

Practices

Seminars

1 Mathematical basics. Scalars and vectors

Dr. Visegrády Balázs

2 Physical quantities and units


3 Motion on a straight line. Kinematics

Dr. Pasitka Jonatán

4 Circular motion.


5 Force, Newton's laws.


6 Dynamics, types of forces


7 Work and energy. Friction.

Dr. Grama László

8 Conservation of mechanical energy.

Dr. Grama László

9 Rotational motion. Torque.


10 Equilibrium.


11 Momentum, conservation of momentum


12 Angular momentum, conservation of angular momentum


13 Oscillations.

Leipoldné Dr. Vig Andrea Teréz



36

14 Waves.


15 Internal energy, heat, temperature


16 1st and 2nd laws of thermodynamics.


17 Hydrostatics.

Dr. Grama László

18 Hydrodynamics.

Dr. Grama László

19 Electricity.


20 Magnetism.


21 Electromagnetic waves.

Dr. Grama László

22 Optics.

Dr. Grama László

23 Test writing


24 Test writing



Can be found on the website of PotePedia.

The seminar strengthens physics theoretical background and provide further understanding through evaluation of exercises (calculations)

hence the written test at the end of the semester includes theoretical questions and exercises.

Participants

Dr. Bódis Emőke (FQFH76), Dr. Grama László (J7AF3B), Dr. Pasitka Jonatán (O1L51K), Dr. Visegrády Balázs (M4AZ6O), Leipoldné

Dr. Vig Andrea Teréz (OL4J1R)



37

OPE-HPR-T HEALTH PROMOTION






Topic

Health promotion is intimately related not only to preventive medicine, but to the everyday practice of physicians as well. A considerable

part of noninfectious diseases is preventable, morbidity and mortality of these illnesses are decreasable by the implementation of effective

intervention.



Mid-term exams

Neptun Meet Street


There are no make-up classes

Reading material



Education material on Neptun

- Notes


Lectures

1 Definitions of health. Health and its relation to everyday life.

Dr. Horváth-Sarródi Andrea

2 Theoretical background of health promotion. Salutogenesis and pathogenesis.


3 Health promotion and health education.


4 Basic documents of health promotion.


5 Methods of health promotion.


6 Measuring of results in health promotion activities. Evidence based health promotion.


7 Health promotion and health policy.


8 Lalonde model. Health in all policies (HiAP).


9 Multisectorality. Stakeholders.


10 Health Impact Assessment (HIA).


11 Health promotion in communities.


12 Health planning.


13 SWOT-analysis.


14 Personal health planning.




38

15 Effective health promotion in settings (schools)


16 Effective health promotion in settings (work places)


17 Health Promoting Universities.


18 Actuality and possibilities of the concept of Health Promoting Universities.


19 Methods of mental health promotion.


20 Promotion of positive mental health and possibilities of prevention of mental disorders.


21 Mental health policy.


22 Role of physicians in the primary, secondary and tertiary levels of prevention.


23 Complex health promotion programs.


24 Examples for effective health promotion activities.


Practices

Seminars


Neptun Meet Street

Participants



39

OPE-SP1-T PHARMACY BIOPHYSICS SEMINARS 1

Course director: ILDIKÓ PÉCSI, assistant professor




Course headcount limitations (min.-max.): 5 – 100 Prerequisites: OPO-Z1E-T parallel

Topic

The course is focusing on solving problems in order to have a deeper understanding of the theory.



Mid-term exams

During the semester the student will have to write a test solving problems.


Missed seminars cannot be made up

Reading material


https://aok.pte.hu/hu/egyseg/10


Handouts and other online materials can be found on the departmental website (https://aok.pte.hu/hu/egyseg/10)

- Notes



Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, 2009

P.W. Atkins: Physical chemistry

Lectures

Practices

Seminars

1 Gas laws

Dr. Lukács András Szilárd

2 Energy, work, Ist law of thermodynamics


3 Heat capacity, calorimetry.


4 Enthalpy


5 Carnot cycle. Classical definition of entropy


6 Statistical definition of entropy.


7 IInd law of thermodynamics


8 Membrane potential, Nernst equation

Pécsi Ildikó

9 Oscillatory motion


10 Wave motion, interference, diffraction


11 Atomic models

Dr. Szabó-Meleg Edina






40

12 Test

Pécsi Ildikó

13 Cytoskeletal proteins

Pécsi Ildikó

14 Motor proteins

Pécsi Ildikó



Participants

Dr. Lukács András Szilárd (LZ2I4Q), Dr. Pasitka Jonatán (O1L51K), Karádi Kristóf Kálmán (X1QYKT), Pécsi Ildikó (ED6HUG)




41

OPF-AR2-T ART THERAPY 2. MANAGEMENT OF PSYCHOSOMATIC DISEASES



1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2



Topic

Art therapy is based on the idea that the traumatic experience may not be accessible verbally but instead is locked in a subconscious

form. Metaphoric cues employed in art methods allow the delicate, ecological transformation of unpleasant experience into conscious

knowledge, and turn the emotional or physical pain into a resource. The course is focused on the management of psychosomatic diseases

(diagnosis, treatment, prevention) with the methods of art therapy. Improvement of awareness in relationships and lifestyle, work with

self-esteem, development of creative thinking and problem solving, training of focusing, generalization, and isolation of the main ideas,

improvement of verbal and fine motor skills,- are the few additional assets of the course which might be beneficial for the future

physicians. The methods are designed for persons with ordinary creative skills, thus do not require special equipment or abilities. Students

can expect informative and well-structured lectures followed by dynamic, interactive seminar classes. Topics of the second semester: art-

management of feeding disorders, respiratory diseases, sexual dysfunction and infertility, autoimmune and skin diseases.



Mid-term exams

Completed practical tasks, written test.


Presentation on topic.

Reading material



The slides will be available.

- Notes


Lectures

1 Pain as a language of the subconscious. Psychological concept and mechanisms of pain.

Zagorácz Olga

2 Psychosomatic aspects of feeding/weight disorders. Adequate comprehension of body needs.

Zagorácz Olga

3 Psychosomatic aspects of respiratory diseases.

Zagorácz Olga

4 Psychosomatic aspects of sexual dysfunction and infertility. Types and inducing factors of sexual dysfunction.

Zagorácz Olga

5 Psychosomatic aspects of autoimmune diseases. Basics of psychotherapy in autoimmune patients.

Zagorácz Olga

6 Psychosomatic aspects of skin diseases. Development of the emotional intellect.

Zagorácz Olga

Practices

Seminars

1 Management of pain in art-therapeutic (AT) practice.

Zagorácz Olga

2 Management and prevention of feeding disorders in AT practice.

Zagorácz Olga

3 Management and prevention of respiratory diseases in AT practice.

Zagorácz Olga

4 Management and prevention of sexual dysfunction in AT practice.

Zagorácz Olga



42

5 Management and prevention of diabetes mellitus, bronchial asthma, allergies in AT practice.

Zagorácz Olga

6 Management and prevention of skin diseases in AT practice.

Zagorácz Olga



Participants

Zagorácz Olga (J5ZJ9T)



43

OPF-BMK-T METHODS AND EXPERIMENTS IN MOLECULAR BIOLOGY

Course director: DR. KATALIN SIPOS, associate professor

Department of Pharmaceutical Biology [email protected]




Topic

We will analyze famous and interesting molecular biological experiments and examine the development and everyday importance of

methods used in molecular biology. We will pay special attention for experimental areas of pharmaceutical research. We hope the course

material will help the students to develop problemsolving thinking.



Mid-term exams

The course will end with a written exam.


According to personal agreement

Reading material



Scientific articles in English

- Notes


Lectures

Practices

Seminars

1 Methods to follow replication.

Dr. Sipos Katalin

2 Molecular biological methods of cell cycle examinations

Jánosa Gergely

3 PCR

Jánosa Gergely

4 Array methods

Dr. Sipos Katalin

5 Blotting methods

Pap Ramóna

6 Labeling methods in the molecular biology

Jánosa Gergely

7 Gene regulation in the prokaryotes

Dr. Sipos Katalin

8 Gene regulation in the eukaryotes.

Dr. Sipos Katalin

9 Genetically modified animals

Jánosa Gergely

10 Experimental planning in pharmaceutical research I.

Dr. Pandur Edina

11 Experimental planning in pharmaceutical research II.

Dr. Pandur Edina

12 Real time PCR

Pap Ramóna

13 Methods in cell culture experiments

Pap Ramóna



44

14 Exam

Dr. Sipos Katalin


No extra exam questions. The basis of the exam is the material of the seminars.

Participants

Dr. Pandur Edina (ZP0077), Dr. Sipos Katalin (RUHPLE), Jánosa Gergely (U3SEOW), Pap Ramóna (OGEM0W)



45

OPF-ETF-T PREPARATION FOR THE PHYSIOLOGY

Course director: DR. ISTVÁN SZABÓ, assistant professor





Topic

The purpose of the course is to assist first-year dentistry and pharmacist students in repeating high school knowledge required to

understand physiology lectures and practices through specific physiological examples.



Mid-term exams

According to the university's regulations


The illustrations used during the seminars and made there are available to students

Reading material


Physiology textbooks


Figures of the seminars

- Notes

Website of the Institute of Physiology: physiology.aok.pte.hu, and the own notes of students


Physiology textbooks

Lectures

Practices

Seminars

1 Arithmetics, elementary algebra

Dr. Szabó István

2 Elementary vector algebra, properties of functions

Dr. Szabó István

3 Elementary geometry, SI system of units

Dr. Szabó István

4 Newtonian mechanics, basics of fluid mechanics

Dr. Szabó István

5 Basics of thermodynamics, basic properties of gas mixtures

Dr. Szabó István

6 Basics of electronics

Dr. Szabó István

7 Basics of optics

Dr. Szabó István

8 Elementary particles of atoms, chemical bonds

Dr. Szabó István

9 Basic chemical calculations, solutions

Dr. Szabó István

10 Osmosis, pH, simple inorganic compounds and ions

Dr. Szabó István

11 Electrochemistry

Dr. Szabó István

12 Basics of organic chemistry

Dr. Szabó István

physiology.aok.pte.hu



46


Test questions based on the topics of seminars

Participants

Dr. Szabó István (GKFKFI)



47

OPF-FPB-T BIOLOGICAL APPLICATIONS OF FLUORESCENCE POLARIZATION METHODS

Course director: DR. SÁNDOR KUNSÁGI-MÁTÉ, associate professor

Department of Organic and Pharmacological Chemistry [email protected]



Course headcount limitations (min.-max.): 2 – 12 Prerequisites: OGA-ALK-T completed

Topic

The property of some materials that they are showing light emission under irradiation made considerable development in studies

performed on complex biological systems. This is because considering that only a part of materials produces fluorescence and this

fluorescence is characteristic for the given material and also by the nanosecond timeframe of the fluorescence, the related methods show

high selectivity and applicable also to study the most molecular motions too. The polarization of light which is associated to the main

characteristics of the materials offers additional selectivity for the measuring techniques, therefore applicable for analytical purposes too.

In the frame of this course further the fundamentals of fluorescence polarization and the related equipments the following topics will be

discussed: immune-fluorescence, fluorescence-activated cell-selection, resonance energy transfer, applications of polarization of the

intrinsic and extrinsic protein fluorescence, investigation of the interactions and transfers of some selected toxins and drugs (antibiotics,

cytotoxic drugs) by fluorescence polarization measurements, applications in HPLC detectors and fluorescent flow cytometry. Students

will be known through the most recent scientific results about the pharmaceutical applications of the methods listed above, will have

ability for successful application of the related measuring and data-evaluating methods. The curse gives considerable support to earn the

drug-designer attitudes of pharmacists.



Mid-term exams

One test in the 10th week, one summary prepared about the topic of lectures and one presentation prepared within the scope of the course.


Reading material


David Freifelder: Physical Biochemistry


Slides and notes of all lectures are available electronically. All topics discussed will be associated with papers published recently.

Those papers together with the related doctoral dissertations in English will also be offered to support the teaching.

- Notes






Lectures

1 General overview on the applicability of fluorescence polarization methods in biology, experiments raises the necessity of the

applications. Anomalies obtained in measurements based on the intensity changes of fluorescence signal.

Dr. Kunsági-Máté Sándor

2 Rotation of molecules, rotational diffusion. Characteristic changes obtained during the adsorption of small molecules onto the

large surfaces.


3 Fundamentals of the fluorescence processes, Jablonski diagram. Effects disturbs the fluorescence measurements: Rayleigh-

scattering, Raman-scattering, inner filter effect.


4 Emission surfaces: fluorescence characteristics of Tripaflavin, Rheonin A, Aurophospin and of the Rodamine B.


5 Dependence of the fluorescence polarization on the molecular environment: the role of the viscosity and the temperature.


6 Correlation between the polaroization of light and the absorption and emission transitions associated to the molecular skeleton

and the related absorption and emission oscillators.




48

7 The Perrin-Ljovsin and Szvesnyikov-Feofilov equations. Expectation of the real polarization. Relationnship between the

anisotropy and the degree of polarization.


8 Methods to determine the real polarization spectra: extrapolation from measurements of two samples having different viscosities

and/or temperatures.


9 Detectors implemented in HPLC equipments and in the cytometers to measure the fluorescence polarization.


10 Circumstances disturbing the measurements: consideration of the inner filter effect and possibilities of their elimination. Protein

dynamics in cases of highly light-scattering samples.


11 Calculation the corrected polarization spectra. Consequences of Kasha-rule on fluorescence polarization, the inner quantum

efficiency.


12 Fine-structure of polarization spectra, connection to the vibration spectra of molecules.


13 Possibilities according to the determination of theoretical polarization spectra, connections to the quantum chemistry.


14 Measuring the polarization spectra. Right angle and front face optical rearrangements, consequences on measurements of

biological samples.


15 Fluorescence of conjugated aromatic molecular units, relationship between the spectral shift and the degree of conjugation.


16 Experimental and theoretical determination of the polarization spectra of anthracene: comparative study.


17 Protein dynamics: fluorescence of amino acids and advantages of the fluorescence polarization measurements. Exeptional

fluorescence and fluorescence polarization behaviors of azulene.


18 Inclusion complexes of aromatic amino acids formed by cavity-shaped molecules, the measurements of anisotropy lifetime.


19 Effect of microsolvation on the interactions of serum albumins with cavity-shaped molecules applied for molecular packing of

different drug molecules.


20 Determination of cell-membrane fluidity by measuring the fluorescence polarization and anisotropy decay.


21 Fluorescent molecular packers: determination of the microsolvation by solvent relaxation measurements.


22 Determination of the molecular adsorption of Citrinine onto the human serum albumin molecules by fluorescence polarization

methods.


23 Competition of the Citrinine molecules with drugs for the binding sites of albumins.


24 Determination of the molecular adsorption of Ochratoxin A onto the human serum albumin molecules by fluorescence

polarization methods.


25 Competition of the Ochratoxin A molecules with drugs for the binding sites of albumins.


26 Exchange reactions of polyphenols with toxins bonded to proteins, signal changes obtained in fluorescence polarization.


27 Extraction of antibiotics from vaste waters by carbon nanotubes, process followed by the fluorescence polarization.


28 Extraction of antibiotics from vaste waters by carbon nanotubes, process followed by the fluorescence polarization.


Practices

Seminars



49


Rotation of molecules, rotational diffusion. Characteristic changes obtained during the adsorption of small molecules onto the large

surfaces.

Fundamentals of the fluorescence processes, Jablonski diagram. Effects disturbs the fluorescence measurements: Rayleigh-scattering,

Raman-scattering, inner filter effect.

Emission surfaces: fluorescence characteristics of Tripaflavin, Rheonin A, Aurophospin and of the Rodamine B.

Dependence of the fluorescence polarization on the molecular environment: the role of the viscosity and the temperature.

Correlation between the polaroization of light and the absorption and emission transitions associated to the molecular skeleton and the

related absorption and emission oscillators.

The Perrin-Ljovsin and Szvesnyikov-Feofilov equations. Expectation of the real polarization. Relationnship between the anisotropy and

the degree of polarization.

Methods to determine the real polarization spectra: extrapolation from measurements of two samples having different viscosities and/or

temperatures.

Detectors implemented in HPLC equipments and in the cytometers to measure the fluorescence polarization.

Circumstances disturbing the measurements: consideration of the inner filter effect and possibilities of their elimination. Protein dynamics

in cases of highly light-scattering samples.

Calculation the corrected polarization spectra. Consequences of Kasha-rule on fluorescence polarization, the inner quantum efficiency.

Fine-structure of polarization spectra, connection to the vibration spectra of molecules.

Possibilities according to the determination of theoretical polarization spectra, connections to the quantum chemistry.

Measuring the polarization spectra. Right angle and front face optical rearrangements, consequences on measurements of biological

samples.

Fluorescence of conjugated aromatic molecular units, relationship between the spectral shift and the degree of conjugation.

Experimental and theoretical determination of the polarization spectra of anthracene: comparative study.

Protein dynamics: fluorescence of amino acids and advantages of the fluorescence polarization measurements. Exeptional fluorescence

and fluorescence polarization behaviors of azulene.

Inclusion complexes of aromatic amino acids formed by cavity-shaped molecules, the measurements of anisotropy lifetime.

Effect of microsolvation on the interactions of serum albumins with cavity-shaped molecules applied for molecular packing of different

drug molecules.

Determination of cell-membrane fluidity by measuring the fluorescence polarization and anisotropy decay.

Fluorescent molecular packers: determination of the microsolvation by solvent relaxation measurements.

Determination of the molecular adsorption of Citrinine onto the human serum albumin molecules by fluorescence polarization methods.

Competition of the Citrinine molecules with drugs for the binding sites of albumins.

Determination of the molecular adsorption of Ochratoxin A onto the human serum albumin molecules by fluorescence polarization

methods.

Competition of the Ochratoxin A molecules with drugs for the binding sites of albumins.

Exchange reactions of polyphenols with toxins bonded to proteins, signal changes obtained in fluorescence polarization.

Extraction of antibiotics from vaste waters by carbon nanotubes, process followed by the fluorescence polarization.

Participants



50

OPF-H2A-T MEDICAL HUNGARIAN 2A - COMMUNICATION SKILLS





Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPF-H1A-T completed + OPF-H2B-T parallel

Topic

This course is meant to serve as a transition between general and specific (doctor-patient) communication skills development.



Mid-term exams


In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material




http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

- Notes



Lectures

Practices

Seminars

1 Logical relations, comparison

2 Logical relations, comparison

3 Giving orientation, informing people

4 Giving orientation, informing people

5 Giving descriptions, requesting and providing information

6 Giving descriptions, requesting and providing information

7 Cause and consequence

8 Medication and effects

9 Narratives

10 Narratives

11 Giving advice

12 Giving advice

13 Expressing uncertainty

14 Expressing uncertainty

15 Test 1

16 Test 1

17 Descriptions, warning

18 Descriptions, warning

19 Polite request, command and warning

20 Polite request, command and warning

21 Parts of the human body, pain, basic symptoms

22 Parts of the human body, pain, basic symptoms

23 History taking: presenting complaints, location, direction and character of pain

24 Test 2.








51

Participants







52

OPF-H2B-T MEDICAL HUNGARIAN 2B - LANGUAGE POINTS





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1B-T completed + OPF-H2A-T parallel

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

This course is meant to provide the language basis for advanced communication between doctors and patients.



Mid-term exams


To be discussed with the course tutor.

Reading material





- Notes


Lectures

Practices

Seminars

1 Expressing possessing, genitive case

2 Expressing possessing, genitive case

3 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

4 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

5 Question words, concerning time and location and adverbs of time

6 Question words, concerning time and location and adverbs of time

7 Expressing cause, giving explanation

8 Expressing cause, giving explanation

9 Functions of past tense in medical Hungarian

10 Functions of past tense in medical Hungarian

11 Future tense, modality expressing ability and volition

12 Future tense, modality expressing ability and volition

13 Impersonalization

14 Impersonalization

15 Consolidation test 1

16 Test 1

17 Modality expressing necessity, possibility and prohibition

18 Modality expressing necessity, possibility and prohibition

19 Definite and indefinite conjugation, prefixed verbs

20 Definite and indefinite conjugation, prefixed verbs

21 Imperative forms

22 Imperative forms

23 Giving instructions to patients

24 Test 2.




53



Participants








54

OPF-IZM-T MOLECULAR BASIS OF MUSCLE FUNCTION

Course director: DR. DÉNES LŐRINCZY, professor emeritus




Course headcount limitations (min.-max.): 1 – 30 Prerequisites:

Topic

The structure of muscle based on light, phase contrast, polarized and electron microscopic observations. Elastic behaviour of passive and

active muscle, types of muscle contractions, muscle force-length relationship. Work done by the muscle, muscle efficiency and heat

production. Thermoelastic behaviour of muscle. Muscle models based on mechanical and structural investigations. Bioelectrical

phenomena, excitation-contraction coupling. Energetics of muscle function, structure of muscle proteins (actin, myosin etc.), analysis of

sliding model. Energetic and spectroscopic investigations in the research of molecular dynamic and thermodynamic background of

muscle function.


The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -

should prepare and will be tested from the missed topics given by the instructor. In the case of more than three absences the course can

not be accepted.

Mid-term exams

Written test at the end of semester.


The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -

should prepare and will be tested from the missed topics given by the instructor.

Reading material



It will be announced at the beginning of the course depending on the possibilities of libraries of Biophysical Department, Faculty of

Medicine. A permanent source could be the roaming in the Internet.

- Notes


Lectures

1 The composition of muscle.

Dr. Lőrinczy Dénes

2 The sorts of muscle.


3 The structure of muscle on the basis of light, phasecontrast and polarization microscope.


4 Structure of muscle by ELMI.


5 Sorts of muscle contraction.


6 Elastic behaviour of passive and active muscle.


7 Muscle force and length relationship, Hill`s equation.


8 Work and heat production done by a muscle, efficiency of muscle function.


9 Thermoelastic behaviour of muscle.


10 Muscle models proposed by mechanical and structural investigations.


11 Biochemical basis and energetics of muscle function.




55

12 Bioelectrical phenomena. Action potentials.


13 Nernst equation, G-H-K equation.


14 Voltage- and patch-clamp techniques.


15 Excitation-contraction coupling.


16 Structure of muscle proteins (actin and myosin, actomyosin complex).


17 Discussion of sliding model in details (x-ray diffraction).


18 Molecular dynamic background of muscle contraction (EPR spectroscopy)


19 Muscle in the sport and rehabilitation (wellness).


20 Principle of differential scanning calorimetry.


21 Thermodynamic background of muscle contraction (DSC results)


22 Muscle and levers in locomotion.


23 Written test.


24 Written test.


Practices

Seminars


Written test

Participants



56

OPF-MGY-T MEDICINAL PLANTS IN THE MECSEK MOUNTAIN

Course director: DR. NÓRA PAPP, associate professor





Topic

The course includes 8x2 lectures and 3 practices (2 + 2x3). The aim of the course is to practice the correct identification of medicinal

plants including the main morphological characters, habitat, collection place, and therapeutical use of the species. The course gives a

general overview on the most frequently used medicinal plants, protected and cultivated species, as well as various vegetation types in

the Mecsek mountain and its environment. In addition, the effect and relationship between abiotic factors and secondary metabolites of

plants are also discussed, which can provide recommendations for collection place and habitat of plants.


Maximal absences: 2 /semester.

Mid-term exams

Fulfillment of 2 tests based on the lectures and practices.


http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640

http://aok.pte.hu/en/egyseg/oktatasianyagok/1640

Teaching supplements in Neptun /MS Teams.

Reading material



Lectures in Neptun / MS Teams.

- Notes


Lectures

1 Definitions related to vegetations of medicinal plants, ecological characters of habitats

Dr. Papp Nóra

2 Definitions related to vegetations of medicinal plants, ecological characters of habitats

Dr. Papp Nóra

3 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship among medicinal plant populations

and their environment with case studies

Dr. Papp Nóra

4 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship among medicinal plant populations

and their environment with case studies

Dr. Papp Nóra

5 Vegetations in the Mecsek mountain I: medicinal plants of oakwoods, hornbeam-oak forests, beech and karst shrub forests

Dr. Papp Nóra

6 Vegetations in the Mecsek mountain II: medicinal plants of rock grasses, swamps and alder gallery forests

Dr. Papp Nóra

7 Medicinal plants at road edge vegetations; protected and cultivated plants in the Mecsek mountain

Dr. Papp Nóra

8 Medicinal plants at road edge vegetations; protected and cultivated plants in the Mecsek mountain

Dr. Papp Nóra

9 Field work methods for identification of medicinal plants

Dr. Papp Nóra

10 Field work methods for identification of medicinal plants

Dr. Papp Nóra

11 Field study of medicinal plants by handout

Dr. Papp Nóra





57

12 Field study of medicinal plants by handout

Dr. Papp Nóra

13 Study and evaluation of field diaries on medicinal plants I.

Dr. Papp Nóra

14 Study and evaluation of field diaries on medicinal plants I.

Dr. Papp Nóra

15 Study and evaluation of field diaries on medicinal plants II., Written test

Dr. Papp Nóra

16 Study and evaluation of field diaries on medicinal plants II., Written test

Dr. Papp Nóra

Practices

17 Medicinal plants of the Mecsek mountain on herbaria

Dr. Papp Nóra

18 Medicinal plants of the Mecsek mountain on herbaria

Dr. Papp Nóra

19 Medicinal plants in oakwood forest (Dömörkapu)

Dr. Papp Nóra


Dr. Papp Nóra


Dr. Papp Nóra

22 Plants in the EGSC-Melius Medicinal Plant Garden

Dr. Papp Nóra


Dr. Papp Nóra


Dr. Papp Nóra

Seminars


According to the topics of the course.

Participants

Dr. Papp Nóra (S3PA4G)



58

OPF-N04-T ANATOMICAL TERMINOLOGY

Course director: DR. KATALIN EKLICS-LEPENYE, assistant professor





Topic

The course aims to mediate the basic anatomical terms supporting the studies of anatomy.



Mid-term exams

Midterm test during week 6.

End-of-term test during week 12.


To be discussed with the instructor.

Reading material



- Notes


University Script

Donáth, Tibor: Lexicon Anatomiae. Anatomical Dictionary, Semmelweis, Bp. 1999.

Lectures

Practices

Seminars

1 Structure of anatomical terms.

Terminology of the compact and trabecular bones.

Body Planes, anatomical directions.

2 Structure of anatomical terms.

Terminology of the compact and trabecular bones.

Body Planes, anatomical directions.

3 Surface Features of Bones, Scapula, humerus.

4 Surface Features of Bones, Scapula, humerus.

5 Terminology of the joints. Upper extremity.

6 Terminology of the joints. Upper extremity.

7 Anatomical Terminology of the lower extremity, bones, joints.

8 Anatomical Terminology of the lower extremity, bones, joints.

9 Anatomical Terminology of the Pelvic Girdle. Bones, ligaments, joints.

10 Anatomical Terminology of the Pelvic Girdle. Bones, ligaments, joints.

11 Mid-term test

12 Mid-term test

13 Vertebrae, sternum, costae. Terminology of the vertebral column.

14 Vertebrae, sternum, costae. Terminology of the vertebral column.

15 Terminology of the ligaments and joints of the vertebral column.

16 Terminology of the ligaments and joints of the vertebral column.

17 Anatomical Terminology of the muscular system.

18 Anatomical Terminology of the muscular system.

19 Anatomical terminology of the skull. Calvaria, internal cranial base.

20 Anatomical terminology of the skull. Calvaria, internal cranial base.

21 Anatomical terminology of the skull. External cranial base.

22 Anatomical terminology of the skull. External cranial base.



59

23 End-of-term test.

24 Retake test for those who happen to fail the end-of-term.


Anatomical terminology of the locomotor system (bones, joints, muscles and the skull).

Participants

Eklicsné Dr. Lepenye Katalin (JMXXSC), Nagy Renáta (JR0PVR), Ronczykné Berta Anikó (CJZOFU)



60

OPF-NS2-T NOBEL PRIZE AWARDED CELL BIOLOGY II

Course director: DR. MARIANNA PAP, associate professor






Topic

The aim of the course is to present the most important and most exciting Nobel Prize-winning molecular cell biology discoveries based

on Nobel lectures given by the winners. The background story of the awards reveals many years of research work, good ideas, good

fortune mixed with family and other personal memories. There is no single recipe for success, the road is always a bit different, and

perhaps the only common feature is the teamwork. From the presentations one might get insight of the winners” personality as well. An

important aspect was in the selection of the topics to emphasize their significance (DNA-, RNA-structure and their synthesis, ribosome

function), their impact on current medical way of thinking (e.g. Prions) and diagnostic methods (e.g. recombinant DNA technology,

DNA sequencing), the description of their present and future medical applicability (e.g. in vitro fertilization), as well as to highlight their

potential relations to different diseases (e.g. cell cycle regulation, reprogram of differentiated cells, RNA interference, papillomaviruses,

HIV). Lectures are organized based on the topics related to the weekly schedule of the molecular cell biology course, not in chronological

order. Most of the presented discoveries and experiments are involved in the molecular cell biology course material, so hopefully their

discussion helps in the better understanding of those topics and lead to a more effective and shorter exam preparation.



Mid-term exams

2 written tests: on week 7 and on week 14.


Participation on Hungarian or German lectures is the only possibility to make-up missed lectures.

Reading material



- Notes


www.nobelprize.org

Lectures

1 Passive transport

Dr. Pap Marianna

2 Passive transport

Dr. Pap Marianna

3 Active transport

Dr. Pap Marianna

4 Action of hormones

Dr. Pap Marianna

5 G-proteins and their role in signal transduction

Dr. Pap Marianna

6 G-protein coupled receptors

Dr. Pap Marianna

7 Growth factors

Dr. Pap Marianna

8 Growth factors

Dr. Pap Marianna

9 Reversible protein phosphorylation in signal transduction pathways

Dr. Pap Marianna

10 Reversible protein phosphorylation in signal transduction pathways

Dr. Pap Marianna

11 Genetic control of early embryonic development

http://www.nobelprize.org/



61

Dr. Pap Marianna

12 Genetic control of early embryonic development

Dr. Pap Marianna

13 Programmed cell death

Dr. Pap Marianna

14 Programmed cell death

Dr. Pap Marianna

15 DNA tumor viruses

Dr. Pap Marianna

16 DNA tumor viruses

Dr. Pap Marianna

17 RNA tumor viruses

Dr. Pap Marianna

18 Retroviral oncogenes

Dr. Pap Marianna

19 Telomeres and telomerase activity in cancers

Dr. Pap Marianna

20 Human cell- and tissue transplantation

Dr. Pap Marianna

21 In vitro fertilization

Dr. Pap Marianna

22 The discovery of the green fluorescent protein and its significance in molecular biology

Dr. Pap Marianna

23 Exam

Dr. Pap Marianna

24 Exam

Dr. Pap Marianna

Practices

Seminars


.

Participants



62

OPF-PLH-T THE PLACEBO EFFECT

Course director: TIBOR SZOLCSÁNYI, assistant professor

Department of Behavioural Sciences [email protected]





Topic

The use of placebo effect has been an inherent part of medicine for thousands of years, and in the recent decades it has become an

inevitable element of medical research due to the introduction of placebo controlled clinical trials. In spite of this fact the research

methodology to measure the effectiveness of placebo effect has been clarified only in the last 10-15 years. At the same time researches

on the neurochemical mechanisms underlying the placebo effect have gained a new impetus. Currently, therefore, we have a much greater

understanding of placebo effect in the context of evidence-based medicine than before, which raises new types of ethical questions as

well. During the course we will examine the different aspects of the phenomenon of placebo effect, and the students will gain knowledge

of the current research results on the field. The main topics of the course: the history of the use of placebo therapies, the role of placebo

effect in medical research, the psycho-social factors that are able to induce placebo effect, neurochemical mechanisms underlying the

placebo effect, the ethical implications of the use of placebo effect in medical treatments.



Mid-term exams

Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam

period.


According to the Code of Studies and Examinations.

Reading material


Franklin G. Miller; Luna Colloca; Ted J. Kaptchuk: The Placebo Effect: Illness and Interpersonal Healing, Perspect Biol Med. 2009

; 52(4)

Damien G. Finniss; Ted J. Kaptchuk; Franklin G. Miller; Fabrizio Benedetti: Biological, Clinical and Ethical Advances of Placebo

Effects, Lancet 2010; 375; 686-695

Franklin G. Miller; Donald L. Rosenstein: The Nature and Power of the Placebo Effect, Journal of Clinical Epidemiology 59, 2006;

331-335

Fabrizio Benedetti: Mechanisms of Placebo and Placebo-Related Effects across Diseases and Treatments, Annual Review of

Pharmacology and Toxicology, Vol. 48; 2008; 33-60.

Jozien M. Bensing; William Verheul: The Silent Healer: The Role of Communication in Placebo Effects, Patient Education and

Counseling 80, 2010; 293-299


Additional materials: Neptun MeetStreet

- Notes

--


Fabrizio Benedetti: Placebo Effect, Oxford University Press, Oxford, 2009

Lectures

Lectures

1 Introduction, definitions of placebo effect

Dr. Szolcsányi Tibor

2 The use of placebo effect in the history of medicine


3 The use of placebo effect in the context of medical research: the introduction of randomized placebo controlled clinical trials and

its consequences




63

4 The methodological and ethical challenges of placebo research


5 The main forms of placebo effect (expectancy based / classical conditioning / affective modulation) and their effectiveness in

different diseases


6 The neurochemistry of placebo effect: placebo analgesia


7 The neurochemistry of placebo effect: the cardiovascular and the respiratory system, immune response and hormone secretion,

Parkinson disease


8 The neurochemistry of placebo effect: further results


9 An overview of the psycho-social factors that are able to induce placebo effect


10 Pain management through psychological interventions and placebo analgesia


11 Ethical implications: how to enhance the placebo effect through improving the physician-patient relationship


12 Written test


Practices

Seminars


--

Participants



64

OPF-VEO-T VACCINATION, ANTI-VACCINATION MOVEMENTS: DO MORE HARM THAN GOOD

Course director: DR. KATALIN SZENDI, assistant professor





Topic

Vaccination belongs to one of the most successful modern health care programmes that decreased significantly the number of severe

infectious diseases. In today’s world experts are unable to compete with the media. Several delusions circulate infiltrating the public

opinion related to vaccines. The most susceptible target audience of these beliefs are the half-educated laymen who believe in the media

created pseudoscience. The activity of stubborn anti-vaccine minorities can be dangerous because that may open up new chances of the

spread of infectious diseases.

The objective of the course is to deepen the knowledge of vaccinations concerning the background, benefits, achievements and failures,

and the course also serves as a thought provoking initiation for practitioners relating to possible actions against the anti-vaccination

movements.


Participation in lectures and practicals is obligatory which is registered.

Absences should not exceed 15% (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams


There are no make-up classes.

Reading material



Educational material uploaded on Neptun.

- Notes


Stanley A. Plotkin. History of Vaccine Development. Springer 2011.

Vaccine Fact Book 2013. http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf

WHO, UNICEF, World Bank. State of the world’s vaccines and immunization, 3rd ed., Geneva, World Health Organization, 2009.

Lectures

Practices

Seminars


Neptun

Participants

http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf



65

OPF-XC1-T EXTRACELLULAR VESICLES: BASICS, ISOLATION AND APPLICATION METHODS 1

Course director: KRISZTINA BÁNFAI, assistant lecturer

Department of Pharmaceutical Biotechnology [email protected]



Course headcount limitations (min.-max.): 3 – 20 Prerequisites: OPO-GL1-T completed

Topic

The course provides basic knowledge of different subtypes of extracellular vesicles. It gives a historical overview and detailed role in

physiological processes. Also covers the content and major components of extracellular vesicles. Besides overall theoretical background

of the field, the course gives ability to understand the challenges in different kind of isolation methods. Gives insight into current

application methodologies and future perspectives in the research field. Also highlights several possible molecular mechanisms

modulated by exosomes. The second part of the course mainly focuses on exosomes and their practical applications.

Topics:

- Basics of extracellular vesicles

- History of extracellular vesicles

- Biogenesis and release of extracellular vesicles

- Mechanisms of extracellular vesicle uptake

- Protein content of extracellular vesicles

- RNA content of extracellular vesicles

- Lipid content of extracellular vesicles

- Isolation methods for extracellular vesicles (overview)

- Technical challenges of working with extracellular vesicles

- Exosome isolation techniques from cell culture media

- Isolation of exosomes with differential ultracentrifugation

- Exosome isolation from blood plasma and serum

- Commercial kit based isolation of exosomes

- Minimal requirements for characterization of isolated extracellular vesicles

- Current trends in EV research

- Role of exosomes during aging

- Role of exosomes during tumor development

- Exercise derived exosomes

- Exam

Skills:

The student will have the following skills:

- basic and overall knowledge of extracellular vesicles

- apply different type of isolation methods of extracellular vesicles

- comprehend/resolve pitfalls and challenges of purification and isolation of extracellular vesicles

- apply extracellular vesicle point of view on research field of interest

- plan experiments in research field of interest

- get familiar with current research areas related to extracellular vesicles



Mid-term exams

Grade based on written tests of semester


Attending the course classes is obligatory.

Reading material


Winston Patrick Kuo, Shidong Jia: Extracellular Vesicles: Methods and Protocols, Springer New York, 2017, ISBN 1493972510,

9781493972517


Lecture materials will be published after the class



66

- Notes

Student notes on lectures


Ramirez, M. I., Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., et al. (2018). Technical challenges of working

with extracellular vesiclesvesicles. Nanoscale. 881-906. doi:10.1039/c7nr08360b.

Lectures

1 Basics of extracellular vesicles

Bánfai Krisztina

2 History of extracellular vesicles

Bánfai Krisztina

3 Biogenesis and release of extracellular vesicles

Garai Kitti

4 Mechanisms of extracellular vesicle uptake

Garai Kitti

5 Protein content of extracellular vesicles I.

Bánfai Krisztina

6 Protein content of extracellular vesicles II.

Bánfai Krisztina

7 RNA content of extracellular vesicles I.

Garai Kitti

8 RNA content of extracellular vesicles II.

Garai Kitti

9 Lipid content of extracellular vesicles I.

Bánfai Krisztina

10 Lipid content of extracellular vesicles II.

Bánfai Krisztina

11 Isolation methods for extracellular vesicles (overview)

Garai Kitti

12 Technical challenges of working with extracellular vesicles

Garai Kitti

13 Exosome isolation techniques from cell culture media

Bánfai Krisztina

14 Isolation of exosomes with differential ultracentrifugation

Bánfai Krisztina

15 Exosome isolation from blood plasma and serum

Garai Kitti

16 Commercial kit based isolation of exosomes

Garai Kitti

17 Minimal requirements for characterization of isolated extracellular vesicles I.

Garai Kitti

18 Minimal requirements for characterization of isolated extracellular vesicles II.

Garai Kitti

19 Current trends in EV research I.

Bánfai Krisztina

20 Current trends in EV research II.

Bánfai Krisztina

21 Role of exosomes during aging I.

Dr. Kvell Krisztián

22 Role of exosomes during aging II.


23 Role of exosomes during tumor development I.

Dr. Pongrácz Judit Erzsébet

24 Role of exosomes during tumor development II.

Dr. Pongrácz Judit Erzsébet

25 Exercise derived exosomes I.




67

26 Exercise derived exosomes II.


27 Exam

Bánfai Krisztina

28 Exam

Garai Kitti

Practices

Seminars


At the last class oral test is held upon the exam questions provided during the semester.

Participants



68

OPE-ABI-T APPLIED BIOMETRICS

Course director: DR. KORNÉLIA BORBÁS-FARKAS, assistant professor


1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2



Topic

Basics of biometrical methods are indispensable to understand the scientific results, to plan own research, and to evaluate data. The main

goal of the course is to expand and deepened the basic knowledge of biometrics via solving practical problems.

Object of the course is to demonstrate different type of research with most frequently applied biometrical methods, though representative

examples or with using of the data of the participants.


Problem solving, oral report

Mid-term exams

Short presentation(s) on the classes by the students


Consultation

Reading material



- Notes


Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988

Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994

P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994

Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981

Lectures

1 Introduction to research methodology, refresh the bio-statistical knowledge

Dr. Pótó László

2 Variance analysis

Borbásné Dr. Farkas Kornélia

3 Regression analysis

Dr. Pótó László

4 Correlation analysis


5 Survival analysis


6 Factor analysis


Practices

1 Refresh the bio-statistical knowledge using the SPSS, exercises


2 Variance analysis, post-hoc tests


3 Linear and non-linear regression analysis


4 Parametric and non-parametric(rank-) correlation analysis


5 Survival analysis, Cox-regression analysis...


6 Factor analysis




69

Seminars


It will be given at the first practice

Participants

Borbásné Dr. Farkas Kornélia (IRWZKJ), Dr. Dergez Tímea (HPZ74N), Dr. Pótó László (FIO4UU), Kőnigné Dr. Péter Anikó (L556VJ)



70

OPE-FKS-T PHYSICAL CHEMISTRY PROBLEM SOLVING SEMINAR

Course director: DR. LÍVIA NAGY-ZENGŐ, senior research fellow

Faculty of Natural Sciences - Department of General and Physical Chemistry [email protected]



Course headcount limitations (min.-max.): 3 – 36 Prerequisites: OPA-PC1-T parallel

Topic

This is an elective course, a lecture room practice. It helps the student understanding the ways of calculating quantitative properties of

material, extent of changes and determine important physicochemical parameters. It shows the applicability of the theoretical forms, the

proper using of units in calculations. Showing the applicability of theory it supports bringing close to understanding the principles of

basic course on physical chemistry. The practice is an informal discussion following the physical chemistry I lecturing. The students

obtain problems to solve as home work. These problems are discussed during the practice. During the semester written test are given.

The evaluation is based on the scores. Students taking this course usually can solve easier the calculating problems at the physical

chemistry I course.


Two class absence can be tolerated.

Mid-term exams

The average of the results of two written tests provides the grade recommended.


Full solved problems will be handed over in written form for the absent student.

Reading material


P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722


Physical Chemistry lecture

- Notes

Physical Chemistry lecture notes : http://kemia.ttk.pte.hu/fizkem/oktatas


P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722

D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2

Lectures

Practices

Seminars

1 The properties of gases: states of perfect gas, the gas laws, units.

Dr. Nagyné Dr. Zengő Lívia

2 Basic concepts in thermodynamics, expansion work, internal energy of a system. Application of the first law.


3 Calculation of enthalpy and calorimetry. Calculation of formation enthalpy and the heat capacity (cp, cv).


4 Calculation of the changes in internal energy.


5 Problem solving of entropy, changing of entropy in different processes.


6 Test: the gas laws, the first law, change in internal energy of a system, the heat capacities and entropy


7 Problems of the kinetic model of gases, collision with walls and surfaces.


8 Calculation: First and second rate chemical reactions.


9 Problem solving of second rate chemical reaction and enzyme reaction


http://kemia.ttk.pte.hu/fizkem/oktatas



71

10 Electrochemical calculations: Faraday's laws, conductivity in electrolytes, Nernst equation, Galvan cells


11 Calculation of electrolysis and corrosion


12 Test: problems fom kinetic model of gases, reaction kinetics and Faraday’s laws.



The solved problems will be handed over in written form for the students at the end of the semester.

Participants

Dr. Nagyné Dr. Zengő Lívia (EOQ0QG)



72

OPE-KP2-T BASICS OF CHEMISTRY 2

Course director: DR. PÁL PERJÉSI, professor





Topic

Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating

on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps

understanding the chemistry-related compulsory subjects of the modules.


Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of one of the tests should be above 60%.

The average of the two tests should be above 50%. One re-take chance is allowed. The result of the retake test is combined with the

previously written ones.

Mid-term exams

Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of one of the tests should be above 60%.

The average of the two tests should be above 50%. One re-take chance is allowed. The result of the retake test is combined with the

previously written ones.



Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational

material University of Pécs, 2014

- Notes



J. McMurray, R. C. Fay: Chemistry, 5th edition

Lectures

1 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

2 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

3 Structure of molecules. The valence bond theory

Dr. Perjési Pál

4 Structure of molecules. The valence bond theory

Dr. Perjési Pál

5 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

6 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

7 Importance of inorganic compounds in living organisms.

Dr. Perjési Pál

8 Importance of inorganic compounds in living organisms.

Dr. Perjési Pál

9 Structure and reactions of oxygen. Mechanisms of oxygen activation.

Dr. Perjési Pál

10 Structure and reactions of oxygen. Mechanisms of oxygen activation.

Dr. Perjési Pál




73

11 Sulfur: structure and reactivity.

Dr. Perjési Pál

12 Sulfur: structure and reactivity.

Dr. Perjési Pál

13 Nitrogen: structure and reactivity.

Dr. Perjési Pál

14 Nitrogen: structure and reactivity.

Dr. Perjési Pál

15 Phosphorous: structure and reactivity.

Dr. Perjési Pál

16 Phosphorous: structure and reactivity.

Dr. Perjési Pál

17 Carbon: structure and reactivity.

Dr. Perjési Pál

18 Carbon: structure and reactivity.

Dr. Perjési Pál

19 Silicon: structure and reactivity.

Dr. Perjési Pál

20 Silicon: structure and reactivity.

Dr. Perjési Pál

21 Boron and aluminium: structure and reactivity.

Dr. Perjési Pál

22 Boron and aluminium: structure and reactivity.

Dr. Perjési Pál

23 Coordination compounds I. The metal-ligand bonding.

Dr. Perjési Pál

24 Coordination compounds I. The metal-ligand bonding.

Dr. Perjési Pál

25 Coordination compounds II. Isomerism.

Dr. Perjési Pál

26 Coordination compounds II. Isomerism.

Dr. Perjési Pál

27 Coordination compounds III. Biochemical importance.

Dr. Perjési Pál

28 Coordination compounds III. Biochemical importance.

Dr. Perjési Pál

Practices

Seminars


Written test covering the topics of the lectures.

Participants

Dr. Perjési Pál (F4H45V)



74

OPE-QAS-T QUANTITATIVE ANALYTICAL CHEMISTRY CALCULATION

Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor





Topic

The Quantitative analytical chemistry calculation course helps students to understand the analytical (titrimetric) calculations. It makes

theoretical backgrounds more understandable.


According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester. The result of both tests should be above 60%.

Mid-term exams

Two written exams during the semester.


Missing written exams should be made up.

Reading material


Harris D.C.: Quantitative Chemical Analysis, 8th ed., W.H. Freeman and Co., New York, 2010


Handouts.

- Notes


Lectures

Practices

Seminars

1 Introduction - Concentrations - Concentration of standard solutions.

Dr. Kulcsár Győző Kornél

2 Introduction - Concentrations - Concentration of standard solutions.


3 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.


4 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.


5 Neutralization analysis - Standardization of a titrant. Titration curve calculations.


6 Neutralization analysis - Standardization of a titrant. Titration curve calculations.


7 Calculation of pH in titration problems I. Hydrolysis of salts.


8 Calculation of pH in titration problems I. Hydrolysis of salts.


9 Calculation of pH in titration problems II. Buffers.


10 Calculation of pH in titration problems II. Buffers.


11 Non-aqueous titration calculations.


12 Non-aqueous titration calculations.




75

13 Complexometry - Methods for calculating the titration results.


14 Complexometry - Methods for calculating the titration results


15 Complex chemical equilibria - Calculations with the stability constants.


16 Complex chemical equilibria - Calculations with the stability constants.


17 Redox titrations II. - Calculations based on oxidimetry.


18 Redox titrations II. - Calculations based on oxidimetry.


19 Redox titrations I. - Redox titration curve calculations.


20 Redox titrations I. - Redox titration curve calculations.


21 Redox titrations I. - Calculations based on oxidimetry.


22 Redox titrations I. - Calculations based on oxidimetry.


23 Redox titrations III. - Calculations based on reductometry.


24 Redox titrations III. - Calculations based on reductometry.


25 Precipitate formation titrations - Calculations for the solubility products.


26 Precipitate formation titrations - Calculations for the solubility products.


27 Gravimetry.


28 Gravimetry.



The final grade is established based on the average of each written exams.

Participants

Dr. Kulcsár Győző Kornél (R7V5ZT), Dr. Mészáros Petra (C705FN), Dr. Tyukodi Levente (IWJHJA)



76

OPE-DRD-T DRUG DESIGN

Course director: DR. CSABA HETÉNYI, associate professor





Topic

The course offers an overview of the whole process of drug design between selection of the disease and marketing of the drug. The

introductory lectures are followed by detailed reviews of certain phases of drug design including prediction of both drug action and

pharmacokinetic properties. In this regard, theoretical and experimental methods of drug design will be also introduced. Case studies will

demonstrate successful examples and also difficulties arising during the design process. Students with a researcher attitude are primary

targets of this course. Besides them, the course provides useful knowledge for future medical doctors and pharmacists as it explains the

complex process of drug discovery in a comprehensible way. This hopefully helps the students navigating in the jungle of laws of

pharmacology also used in molecular design. Furthermore, the course deals with the problems of prediction of toxicity and side-effects,

and discusses certain questions of production and legalization process of new drugs, as well. In Journal Club sessions, recent research

articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the

students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge in drug design.


Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit

megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a

helyzet szabályzását és 50 % mértéket a hiányzásoknál.

Mid-term exams

There is a final test announced at the end of the semester. The test will include multiple choice questions or short essays. A mark is

offered according to the results of the written test or optionally by evaluation of the student's presentation prepared for the Journal Club.

The student can improve the mark according to university regulations.


Replacement is possible according to personal consultation.

Reading material



The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the

Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.

- Notes


Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press

Lectures

1 Selection of the disease. Goals, terminology, trends.

Dr. Hetényi Csaba

2 Conditions. Strategies. Ligand-based design.

Dr. Hetényi Csaba

3 Traditional design.

Dr. Hetényi Csaba

4 Target-based drug design.

Dr. Hetényi Csaba

5 Target selection and validation.

Dr. Hetényi Csaba

6 Protein targets 1. General overview, structural proteins.

Dr. Hetényi Csaba

7 Protein targets 2. Enzymes and receptors.

Dr. Hetényi Csaba

8 Experimental structure determination methods.

Dr. Hetényi Csaba

9 Theoretical structure determination methods.



77

Dr. Hetényi Csaba

10 Lipids and nucleic acids as targets.

Dr. Hetényi Csaba

11 Journal club 1. Comparison of strategies

Dr. Hetényi Csaba

12 Journal club 2. Evaluation of targets

Dr. Hetényi Csaba

13 Experimental methods of lead selection and design.

Dr. Hetényi Csaba

14 Molecular complexes of leads. Thermodynamic and kinetic stability.

Dr. Hetényi Csaba

15 Theoretical methods of lead selection and design.

Dr. Hetényi Csaba

16 Lead optimizations, transformations.

Dr. Hetényi Csaba

17 ADMETox optimization 1. Goals, general description.

Dr. Hetényi Csaba

18 ADMETox optimization 2. Methods.

Dr. Hetényi Csaba

19 Termination of design. Production and development. Side-effects and postmarketing surveillance.

Dr. Hetényi Csaba

20 Case studies. The design of antiviral drugs.

Dr. Hetényi Csaba

21 Journal club 3. Development of new methods

Dr. Hetényi Csaba

22 Journal club 4. Paradigm shifts of drug design

Dr. Hetényi Csaba

23 Test

Dr. Hetényi Csaba

24 Test

Dr. Hetényi Csaba

Practices

Seminars


Lists of questions will be provided at the end of each lecture specifying the required knowledge.

Participants



78

OPE-ETI-T PHARMACY ETHICS

Course director: TIBOR SZOLCSÁNYI, assistant professor


1 credit ▪ midsemester grade ▪ Elective subject for the medical-biological module ▪ spring semester ▪ recommended semester: 2



Topic

The aim of the course is to help students gain sensitivity to the ethical issues connected to the pharmacy practice. During the course

students learn about the basic ethical principles governing the pharmacist-patient and the pharmacist-physician relationship. Students

also get acquainted with the dilemmas that are raised by the conflict between business and ethics in pharmacy. The most important

concerns of research ethics and some specific ethical issues, like the question of mind-enhancing drugs, are also discussed during the

course.



Mid-term exams

Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam

period. Oral exam is also an option for that purpose.


According to the Code of Studies and Examinations

Reading material


--


Additional materials: Neptun MeetStreet

- Notes

--


Robert Veatch and Amy Haddad (eds.): Case Studies in Pharmacy Ethics, 2nd edition, Oxford University Press, New York, 2008

Lectures

Practices

Seminars

1 Introduction


2 A short history of pharmacy


3 General ethical viewpoints


4 The principle of informed consent in modern health-care


5 The ethics of patient-pharmacist relationship


6 The ethics of physician-pharmacist relationship


7 The conflict between business and ethics in pharmacy


8 The placebo effect and its ethical concerns


9 Dietary supplements, performance- and mind- enhancing drugs


10 Ethical issues in clinical drug trials




79

11 Summarizing discussion


12 Test



--

Participants

Dr. Szolcsányi Tibor (HNQ526)



80

OPE-GKT-T HISTORY OF MANUFACTURE OF MEDICINES

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]




Topic

Aim of the course is to explain the importance of the birth of Pharmaceutical Technology, introducing the manufacture of medicines

from the ancient times until the new age. Lectures will explain how first medicines were made, how the first pharmaceutical technological

equipments were created and how the mass production of drugs became more and more important. Lectures will also elaborate the birth

of famous medicines, like the quinine, aspirin, insulin and the sildenafil.



Mid-term exams

- participation on the lectures

- accepted work reports

- accepted written assessments

Students have to write an end-semester assessment from the lectures at acceptance level of 60%.


Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and

work reports.

Reading material



- Notes


Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare

Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone

Lectures

1 Introduction

Dr. Pál Szilárd

2 introduction

Dr. Pál Szilárd

3 Ancient technologies (Egypt, Greece, Persian Empire)

Dr. Pál Szilárd

4 Ancient technologies (Egypt, Greece, Persian Empire)

Dr. Pál Szilárd

5 Influence of alchemy to the pharmaceutical technology

Dr. Pál Szilárd

6 Influence of alchemy to the pharmaceutical technology

Dr. Pál Szilárd

7 Middle ages

Dr. Pál Szilárd

8 Middle ages

Dr. Pál Szilárd

9 Effect of industrial revolution

Dr. Pál Szilárd



81

10 Effect of industrial revolution

Dr. Pál Szilárd

11 Development of medicines in the new age

Dr. Pál Szilárd

12 Development of medicines in the new age

Dr. Pál Szilárd

13 Birth of the first industrial manufacturers

Dr. Pál Szilárd

14 Birth of the first industrial manufacturers

Dr. Pál Szilárd

15 Evolution of community pharmacies

Dr. Pál Szilárd

16 Evolution of community pharmacies

Dr. Pál Szilárd

17 Drugs that changed the world

Dr. Pál Szilárd

18 Drugs that changed the world

Dr. Pál Szilárd

19 Invention of the quinine

Dr. Pál Szilárd

20 Invention of the aspirine

Dr. Pál Szilárd

21 Invention of various famous drugs

Dr. Pál Szilárd

22 Invention of the sildenafil

Dr. Pál Szilárd

23 Invention of the insulin

Dr. Pál Szilárd

24 Invention of the insulin

Dr. Pál Szilárd

25 Test

Dr. Pál Szilárd

26 Test

Dr. Pál Szilárd

27 Attending the Saracen Pharmacy in Pécs

Dr. Pál Szilárd

28 Attending the Saracen Pharmacy in Pécs

Dr. Pál Szilárd

Practices

Seminars


Students can get the test topics in the institute or download the from website of the institute.

Participants

Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)



82

OPE-BES-T BIOETHICS SEMINAR

Course director: DR: BEÁTA LAKI, assistant lecturer





Topic

This seminar can be a continuation of the basic Medical ethics course for those student who are interested in the topic more. This course

has the opportunity to examine further interesting and important fields of biomedical ethics which can broaden the view of students and

it can help to be more sensitive for these kind of questions in general.



Mid-term exams

Mid-term test.


Theres is no possibility.

Reading material


Course materials will be available through Neptun MeetStreet.



- Notes




Lectures

Practices

Seminars

1 Bioethics

Dr. Laki Beáta

2 Theoretical introduction

Dr. Laki Beáta

3 Interpretation of basic concepts needed to discuss ethical issues 1.

Dr. Laki Beáta

4 Interpretation of basic concepts needed to discuss ethical issues

Dr. Laki Beáta

5 Interpretation of basic concepts needed to discuss ethical issues 2.

Dr. Laki Beáta

6 Interpretation of basic concepts needed to discuss ethical issues

Dr. Laki Beáta

7 Ethical dilemmas of reproductive medicine - movie

Dr. Laki Beáta

8 Ethical dilemmas of reproductive medicine - movie

Dr. Laki Beáta

9 Ethical dilemmas of reproductive medicine: gestational surrogate motherhood, IVF, stem cell research

Dr. Laki Beáta

10 Ethical dilemmas of reproductive medicine: gestational surrogate motherhood, IVF, stem cell research

Dr. Laki Beáta

11 Ethical issues of genetic interventions

Dr. Laki Beáta



83

12 Ethical issues of genetic interventions

Dr. Laki Beáta

13 Ethical issues of organ- and tissue transplantation

Dr. Laki Beáta

14 Ethical issues of organ- and tissue transplantation

Dr. Laki Beáta

15 Moral questions related to animal testing

Dr. Laki Beáta

16 Moral questions related to animal testing

Dr. Laki Beáta

17 Human experiments

Dr. Laki Beáta

18 Human experiments

Dr. Laki Beáta

19 Environmental Ethics 1.

Dr. Laki Beáta

20 Environmental Ethics

Dr. Laki Beáta


Dr. Laki Beáta


Dr. Laki Beáta

23 Summary of the semester

Dr. Laki Beáta

24 Written, test exam

Dr. Laki Beáta



Participants

Dr. Laki Beáta (B0SCQX)



84

OPE-JEA-T DISEASES OF SIGNAL TRANSDUCTION

Course director: DR. GYÖRGY SÉTÁLÓ, associate professor




Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-GL1-T completed + OPO-G2B-T parallel


Topic

Topics of signal transduction will be discussed beyond the details of the compulsory course, Molecular cell biology 2. In 12 x 45 minutes

special attention is paid to mechanisms that are relevant to diseases.

The course is recommended to those students who are especially interested in the signaling aspects of pathological processes.



Mid-term exams

Two multiple-choice test-exams, with ~25 questions each, one halfway and another one at the end of the course.


It is not possible to make up for missed classes.

Reading material



Lecturers using ppt will load these up onto the intranet after their class.

- Notes


Lectures

1 The protein kinase A system.

Dr. Sétáló György

2 Signaling in infectious diseases (cholera, pertussis and anthrax).

Dr. Palkovics Tamás

3 Growth factor signaling.


4 Signaling through cell-cell and cell-matrix connections.


5 First test.


6 Stress signaling.

Dr. Bátor Judit

7 Signaling and inflammation.

Dr. Mikó Éva

8 Signaling of apoptosis.

Dr. Pap Marianna

9 Steroid signaling.


10 Integrin signaling and metastasis.

Dr. Berta Gergely

11 Signaling gone wrong in the developing nervous system.

Dr. Ábrahám Hajnalka Gabriella

12 Second test.




85

Practices

Seminars


Multiple-choice test questions based on the actually presented materials of the course.

Participants



86

OPE-SP2-T PHARMACY BIOPHYSICS SEMINARS 2

Course director: ILDIKÓ PÉCSI, assistant professor




Course headcount limitations (min.-max.): 5 – 100 Prerequisites: OPO-Z1E-T completed + OPO-Z2E-T parallel

Topic

The course is focusing on solving problems in order to have a deeper understanding of the theory.



Mid-term exams

During the semester the student will have to write a test solving problems.


Missed seminars cannot be made up

Reading material



Handouts and other online materials can be found on the departmental website (http://biofizika.aok.pte.hu)

- Notes


Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, 2009

P.W. Atkins: Physical chemistry

Lectures

Practices

Seminars

1 Quantum mechanics 1


2 Quantum mechanics 2


3 Absorption spectroscopy


4 Fluorescence spectroscopy 1

Takács-Kollár Veronika Tünde


Pécsi Ildikó


Dr. Ujfalusi Zoltán

7 Fast kinetic methods

Dr. Ujfalusi Zoltán

8 Thermodynamics. Recapitulation


9 Lasers


10 Microscopy

Dr. Szabó-Meleg Edina

11 Mass Spectrometry

Dr. Talián Csaba Gábor

12 Test

Pécsi Ildikó

13 Infrared and FTIR spectroscopy




87

14 Raman spectroscopy



http://biofizika.aok.pte.hu

Participants

Dr. Lukács András Szilárd (LZ2I4Q), Dr. Szabó-Meleg Edina (I0NKTU), Dr. Talián Csaba Gábor (RP9GGL), Dr. Ujfalusi Zoltán

(AZSO9Z), Leipoldné Dr. Vig Andrea Teréz (OL4J1R), Pécsi Ildikó (ED6HUG), Takács-Kollár Veronika Tünde (L5EB78)

http://biofizika.aok.pte.hu/



88

OPF-CY1-T CYBERNETICS FOR MEDICAL, DENTISTRY AND PHARMACY STUDENTS 1

Course director: LÁSZLÓ ZOLTÁN PÉCZELY, assistant professor





Topic

Cybernetics embracing more disciplines deals with the control, regulation, information flow and processing occuring in expediently

working dinamical systems. The most important goal of our subject is to help the students understand the functional principles of the

regulatory systems, mainly those of the human body. Furthermore, we would like to familiarize the students with how the balance of the

regulatory systems can be maintained by their wide adaptive and learning capacity/capability. We would like to demonstrate that etiology

of many diseases can be explained by the disruption of balance, how the balance can be restored by the therapy and, at the same time,

how the therapy can cause the shift of the balance in other parts of the system (side effect). In addition to the biological systems, both

the functional description of the artificial regulatory systems and the artificial intelligence will be addressed. In the first semester the

following topics are discussed: general description of systems, mathematical basics, the concept of homeostasis, biocybernetics of cellular

and subcellular stuctures, mathematical model of the blood coagulation cascade, cardiorespiratoric system as regulatory system,

neuroendocrine regulation.



Mid-term exams

Writing of case study, online test.


Not necessary, but it is possible in another language

Reading material



- Notes


Guyton & Hall: Textbook of Medical Physiology

V. V. Purin, R. M. Buyevskiy: Introduction To Medical Cybernetics

Peter Norvig, Stuart J. Russell: MI modern megközelítésben

James Kneer, James Sneyd: Mathematical Physiology I.: Cellular Physiology

James Kneer, James Sneyd: Mathematical Physiology II.: System Physiology

Lectures

1 Introduction: Cybernetics as discipline, definition of systems, general description. Relationship between system and enviroment.

Living organisms as cybernetic systems. Doctor and patient as the elements of cybernetic system.

Dr. Péczely László Zoltán

2 The concept of information, collecting and storing information, information analysis. Measurement techniques and intervention

issues.


3 Mathematical tools in Cybernetics I


4 Mathematical tools in Cybernetics II


5 Model and reality, deductive and inductive inference, modelling.


6 Homeostasis. Hierarchical structure of the regulation of organism. Role of feedback in regulatory systems.


7 Biocybernetics of cellular and subcellular stuctures, analogies (modelling of membrane processes, integrative description and

models of transductional pathways).


8 Mathematical modelling of the blood coagulation cascade.




89

9 Integrative cardiorespiratoric regulation, regulatory disturbances, options for interventions I


10 Integrative cardiorespiratoric regulation, regulatory disturbances, options for interventions II


11 Integrative neuroendocrine regulation, regulatory disturbances, options for interventions I


12 Integrative neuroendocrine regulation, regulatory disturbances, options for interventions II


Practices

Seminars


The topics of the lectures

Participants



90

OPF-EBK-T FOOD SAFETY AND CRISIS SITUATIONS

Course director: DR. TÍMEA VARJAS, assistant professor






Topic

Although food legislation and legal background is strict in EU some food safety crises and emergencies occur we can hear just a few

word in the media about. This course „pulls the veil” of the background, causes and concealed information of food safety crises. Topics

are about the most interesting and important information of these situations.


Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams

Examination: written test


based on individual consideration

Reading material



PPT-presentations (Neptun)

- Notes


Lectures

1 Introduction

Dr. Raposa László Bence

2 European and Hungarian food safety regulation


3 Cases and concealed facts I. (Historical overview)


4 Cases and concealed facts II.


5 Crisis management and communication I.


6 Crisis management and communication II.


7 Food industry "tricks": Changes which the layman does not realize


8 Food industry "tricks": Changes which the layman does not realize


9 Actual food safety crisis


10 Actual food safety crisis


11 Summary


12 Exam




91

Practices

Seminars


Neptun

Participants



92

OPF-H3A-T MEDICAL HUNGARIAN 3A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY

Course director: GABRIELLA NAGY, assistant lecturer





Topic

This course in devoted to the acquisition of language and communicative functions of the basic history taking process and the description

of medications.



Mid-term exams



Reading material



Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes



Lectures

Practices

Seminars

1 Family History, social history and previous diseases

2 Family History, social history and previous diseases

3 Complaint and Pain

4 Complaint and Pain

5 Headache, dizziness

6 Perspiration, nausea, vomiting

7 Vision, shortness of breath, cough-Listening comprehension and speaking skills

8 Stool, urine

9 Stool, urine

10 Heart complaints, appetite

11 Shivering, fever, oedema

12 Frequent diseases

13 Oesophagus, stomach, gallbladder

14 Bowel diseases, cardiovascular diseases

15 Forms of medications

16 Test 1

17 Types of medications

18 Types of medications

19 Instructions concerning the application of medications: oral medications

20 Instructions concerning the application of medications: oral medications

21 Instructions concerning the application of medications: drops

22 Instructions concerning the application of medications: creams and ointments

23 Prescriptions

24 Test 2.




93



Participants



Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit

(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)




94

OPF-H3B-T MEDICAL HUNGARIAN 3B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY






Topic

This course serves the skills development based on language and communicative functions acquired in course 3A.



Mid-term exams



Reading material



Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes


--

Lectures

Practices

Seminars

1 Family History, social history and previous diseases - Listening comprehension and speaking skills

2 Family History, social history and previous diseases - Listening comprehension and speaking skills

3 Complaint and Pain - Listening comprehension and speaking skills

4 Complaint and Pain - Listening comprehension and speaking skills

5 Headache, dizziness - Listening comprehension and speaking skills

6 Perspiration, nausea, vomiting - Listening comprehension and speaking skills

7 Vision, shortness of breath, cough - Listening comprehension and speaking skills

8 Stool, urine - Listening comprehension and speaking skills

9 Stool, urine - Listening comprehension and speaking skills

10 Heart complaints, appetite - Listening comprehension and speaking skills

11 Shivering, fever, oedema - Listening comprehension and speaking skills

12 Frequent diseases - Listening comprehension and speaking skills

13 Oesophagus, stomach, gallbladder - Listening comprehension and speaking skills

14 Bowel diseases, cardiovascular diseases - Listening comprehension and speaking skills

15 Forms of medications - Listening comprehension and speaking skills

16 Test 1

17 Types of medications - Listening comprehension and speaking skills

18 Types of medications - Listening comprehension and speaking skills

19 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

20 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

21 Instructions concerning the application of medications: drops - Listening comprehension and speaking skills

22 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills

23 Prescriptions - Listening comprehension and speaking skills

24 Consolidation, Test 2.






95

Participants







96

OPF-HB1-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 1

Course director: DR. BALÁZS BOGNÁR, assistant professor




Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-GC1-T completed + OPA-S1E-T parallel

Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Reaction mechanisms in organic chemistry

2. Projection structures, radical substitution

3. Electrophilic addition

4. Electrophilic aromatic substitution

5. Nucleophilic substitution 1, alkyl halides

6. 1. test

7. Nucleophilic substitution 2, organometallics, alcohols, phenols, ethers.

8. Aromatic nucleophilic substitutions

9. Stereochemistry

10. 2. test



Mid-term exams

Nincs.


Nincs

Reading material



The worksheets will be handed on the seminar.

- Notes


Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007

Lectures

Practices

Seminars

1 Reaction mechanisms in organic chemistry.

Dr. Bognár Balázs

2 Projection structures, radical substitutions and nomenclature of alkanes.

Dr. Bognár Balázs

3 Reaction of alkenes and alkynes: electrophilic addition, oxidations.

Dr. Bognár Balázs

4 Aromaticity, electrophilic aromatic substitution: mechanism, examples.

Dr. Bognár Balázs

5 Nucleophilic substitutions of alkyl halides.

Dr. Bognár Balázs

6 1. test (alkanes, alkenes, alkynes, aromatics, organohalides).

Dr. Bognár Balázs



97

7 Nucleophilic substitution 2: synthesis and reactions organometallics, alcohols, phenols, ethers.

Dr. Bognár Balázs

8 Aromatic nucleophilic substitutions of carbocycles.

Dr. Bognár Balázs

9 Stereochemistry: classification of isomerism, absolut configuration.

Dr. Bognár Balázs

10 2. test: alcohols, phenols, ethers, organometallics, isomerism.

Dr. Bognár Balázs


There is no exam.

Participants

Dr. Bognár Balázs (U34DM4)



98

OPF-IPM-T INNOVATION AND PROJECT MANAGEMENT FROM A BUSINESS PERSPECTIVE (KÜLÖN

KURZUS!!!)

Course director: DR. RITA BOGNÁR, research associate professor

Department of Biochemistry and Medical Chemistry [email protected]





Topic

The main objective of the innovation and project management course is to develop the business orientation skills of the students, while

deepening their knowledge in project management theory, methods and practice. Participants will have the capability how to develop

innovative projects for business.



Mid-term exams

Home work tasks in Moodle during the semester. At the end of the course final essay or final written test according to public health

situation.


No way.

Reading material


Not relevant.


Lectures in pdf form will be available on Neptun Meet Street.

- Notes

Not relevant.


1. Joseph W. Weiss, Robert K. Wysocki (1992): 5-Phase Project Management: A Practical Planning & Implementation Guide,

Addison-Wesley

2. John Hauser, Gerard J. Tellis and Abbie Griffin: A Review and Agenda for „Marketing Science”, Marketing Science, Vol. 25, No.

6, 25th Anniversary Issue (Nov. - Dec., 2006), pp. 687-717

3. Barbara J. Gabrys, Jane A. Langdale (2012): How to succeed as a scientist, From Postdoc to Professor, Cambridge University

Press, New York, pp.45-57.

Lectures

1 Basics of project management (definition, objectives)

Dr. Bognár Rita

2 Global business overview

Dr. Bognár Rita

3 Project life cycle

Dr. Bognár Rita

4 Different type of business organization

Dr. Bognár Rita

5 Project initialisation (structure, work packages)

Dr. Bognár Rita

6 Leadership of a project

Dr. Bognár Rita

7 Human resource management (team building, teamwork)

Dr. Bognár Rita

8 Project planning 1. (time, resources)

Dr. Bognár Rita



99

9 Project planning 2. (cost, risk, communication)

Dr. Bognár Rita

10 Project network

Dr. Bognár Rita

11 Project communication tools

Dr. Bognár Rita

12 Project protocol

Dr. Bognár Rita

13 Financial management 1. (Main budget categories)

Dr. Bognár Rita

14 Financial management 2.

Dr. Bognár Rita

15 Procurement management

Dr. Bognár Rita

16 Contracts

Dr. Bognár Rita

17 Risk management

Dr. Bognár Rita

18 Conflict management

Dr. Bognár Rita

19 Project controlling and monitoring

Dr. Bognár Rita

20 Project reporting

Dr. Bognár Rita

21 Project closing

Dr. Bognár Rita

22 Project maintenance

Dr. Bognár Rita

23 Innovation management 1.(Intellectual properties)

Dr. Bognár Rita

24 Innovation management 2. (Patent)

Dr. Bognár Rita

Practices

Seminars


Neptun Meet Street

Participants



100

OPF-MGE-T MOLECULAR GERONTOLOGY

Course director: DR. KRISZTIÁN KVELL, associate professor




Course headcount limitations (min.-max.): 3 – 200 Prerequisites: OPE-MS1-T completed


Topic

The curriculum covers physiological aspects of ageing and the molecular background of the ageing process, at cell, intracellular signaling

and nucleic acid level. It highlights the potential molecular intervention possibilities to slow down the ageing process and decrease

development of age related diseases.



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Basic Knowledge in Gerontology


2 Aging Theories


3 Mitochondrial Aging


4 Aging and Gene Expression


5 Genetic Background of Longevity


6 Alterations of the Genome due to Aging, Senescence and Cancer


7 Cellular Effects of Acute and Chronic Stress


8 Metabolism and Longevity I


9 Metabolism and Longevity II


10 Senescence-related Intracellular Pathologies


11 Senescence-related Intracellular Pathologies


12 Molecular Mechanisms of Interventions


13 Invited Lecturer I


14 Invited Lecturer II


http://www.medbiotech.com/



101

Practices

Seminars


MeetStreet

www.medbiotech.com

Participants

http://www.medbiotech.com/



102

OPF-SNA-T CARBON NANOSTRUCTURES

Course director: DR. BEÁTA LEMLI, assistant professor




Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-ALK-T completed

Topic

Carbon is an indispensable element of life, thanks to the ability to form different chemical bonds with most elements of the periodic

table, enabling the creation of different and complex life forms. The discovery of the organic carbon compounds has been started in the

19th century, and now they are the part of our lives. Nowadays the previously discovered allotropes of carbon - fullerenes, carbon

nanotubes, graphenes, graphene nanoribbons - are in the focus, however, their real wide application still seems to be a big challenge and

needs further investigations. During this curse, students will be introduced to the promising pharmaceutical chemistry, medical and

biological applications of these materials and to the latest results of related research.



Mid-term exams

One written exam during the semester, the acceptance level is 60%. One oral presentation by students.


There is no possibility to make up for a missed lecture and practice

Reading material


Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,

2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442


The slides of the lectures are electronically available.

- Notes


Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,

2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442

Lectures

1 Introduction of the course requirements. Fullerenes, carbon nanostructure, graphene: their discovery, historical review

Dr. Lemli Beáta

2 Fullerenes, carbon nanostructure, graphene: their discovery, historical review

Dr. Lemli Beáta

3 Preparation, synthesis, general properties

Dr. Lemli Beáta

4 Preparation, synthesis, general properties

Dr. Lemli Beáta

5 Covalent and non-covalent functionalization of carbon nanomaterials

Dr. Lemli Beáta

6 Covalent and non-covalent functionalization of carbon nanomaterials

Dr. Lemli Beáta

7 Nanotechnology in wastewater treatment

Dr. Lemli Beáta

8 Nanotechnology in wastewater treatment

Dr. Lemli Beáta

9 Carbon nanostructures and DNA

Dr. Lemli Beáta

10 Carbon nanostructures and DNA

Dr. Lemli Beáta

11 Cellular uptake

Dr. Lemli Beáta



103

12 Cellular uptake

Dr. Lemli Beáta

13 Biodistribution

Dr. Lemli Beáta

14 Biodistribution

Dr. Lemli Beáta

15 Cancer diagnosis and treatment

Dr. Lemli Beáta

16 Cancer diagnosis and treatment

Dr. Lemli Beáta

17 Toxicity

Dr. Lemli Beáta

18 Toxicity

Dr. Lemli Beáta

19 Student’s lecture.

Dr. Lemli Beáta

20 Student’s lecture.

Dr. Lemli Beáta

21 Written test.

Dr. Lemli Beáta

22 Written test.

Dr. Lemli Beáta

23 Summary and conclusions

Dr. Lemli Beáta

24 Summary and conclusions

Dr. Lemli Beáta

Practices

Seminars


The topics of the written test are similar to the topics of the lectures.

Participants



104

OPF-SSG-T HISTOLOGY SEMINAR FOR PHARMACY STUDENTS

Course director: DR. BALÁZS OPPER, assistant professor

Department of Anatomy [email protected]



Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-AI2-T parallel

Topic

The aim of the subject is to complete the knowledge about structure of organ systems. Besides gross anatomy and basic histological

knowledge presented in mandatory anatomy courses, the ‘Histology seminars for pharmacy students’ offers better understanding of

histological background of physiological and oathophysiological processes and conditions.


The semester can not be accepted over 2 absences.

Mid-term exams

Multimedia test on last seminar.


Not possible.

Reading material



http://an-server.pote.hu

- Notes


Lectures

Practices

Seminars

1 Histology of the skin I.

Szabó Edina Ivett

2 Histology of the skin II.

Szabó Edina Ivett

3 Histology of the gastrointestinal tract I.

Szabó Edina Ivett

4 Histology of the gastrointestinal tract II.

Szabó Edina Ivett

5 Histology of the gastrointestinal tract III.

Szabó Edina Ivett

6 Histology of the gastrointestinal tract IV.

Szabó Edina Ivett

7 Histology of the gastrointestinal tract V.

Szabó Edina Ivett

8 Histology of the gastrointestinal tract VI.

Szabó Edina Ivett

9 Histology of the kidney

Szabó Edina Ivett

10 Respiratory system.

Szabó Edina Ivett

11 Histology of the male genitalia I.

Szabó Edina Ivett

12 Histology of the male genitalia II.

Szabó Edina Ivett

13 Histology of the female genitalia I.

Szabó Edina Ivett

http://an-server.pote.hu/



105

14 Histology of the female genitalia II.

Szabó Edina Ivett

15 Histology of the female genitalia III.

Szabó Edina Ivett

16 Histology of the female genitalia IV.

Szabó Edina Ivett

17 Endocrine organs I.

Szabó Edina Ivett

18 Endocrine organs II.

Szabó Edina Ivett

19 Histology of the peripheral nervous system i.

Szabó Edina Ivett

20 Histology of the peripheral nervous system II.

Szabó Edina Ivett

21 Eyebulb I.

Szabó Edina Ivett

22 Eyebulb II.

Szabó Edina Ivett

23 Test

Szabó Edina Ivett

24 Test

Szabó Edina Ivett


http://an-server.pote.hu

Participants

Dr. Füredi Nóra Judit (WD29KK), Dr. Gaszner Tamás (YX6IQ5), Dr. Jüngling Adél (HB0TWF), Dr. Pham Dániel (G6T2FO), Szabó

Edina Ivett (CQY1BL)

http://an-server.pote.hu/



106

OPF-TG1-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 1

Course director: DR. GYÖRGYI HORVÁTH, associate professor





Topic

The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we

wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students

Research Society.


The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in

further semesters.

The prerequisite of this course (TDK 1): registration of the student in the database of Students’ Research Society.

Mid-term exams

TG1

- Topic plan of student’s research project with the confirmation of supervisor

- Introduction of scientific articles found by the student in databases

- The topic plan and articles must be sent for course supervisor at the end of 13th week of the semester.


There is no possibility.

Reading material



- Notes


ScienceDirect database

Lectures

Practices

Seminars


Not applicable.

Participants

Dr. Horváth Györgyi (GDLTCH), Dr. Poór Miklós (ARWF5Z), Dr. Vida Róbert György (BN08GS)



107

OPF-TMB-T MOLECULAR BIOLOGY OF TUMORS

Course director: DR. EDINA PANDUR, assistant professor




Course headcount limitations (min.-max.): 3 – 30 Prerequisites: OPO-GL1-T completed + OPO-G2B-T completed

Topic

During the course we will discuss the molecular mechanisms of tumor development. We will deal with characteristic features of tumor

cells, and cancers. The function of influencing factors, risk factors, causes, the underlying molecular mechanisms, e.g. mutations, the

role of oncogenes and tumor-suppressor genes, DNA repair, epigenetics and the role of immune system will be discussed in detail. We

will emphasize the function of cell signaling pathways and the failure of apoptosis in tumorigenesis. We will speak about the molecular

mechanisms of invasion and metastasis of tumors, the genes and proteins which have a crucial role in these processes. The participants

will get an insight into the molecular diagnosis, genetic aberrations, and molecular alterations of human cancers. We will discuss the

possibilities for cancer therapies, the new approaches such as gene therapy and immunotherapy.


Max. 3 absences

Mid-term exams

One assay, one midterm exam.


Personal consultation

Reading material



Educational materials will be uploaded to Neptun MeetStreet.

- Notes


Lauren Pecorino: Molecular Biology of Cancer

Wolfgang Arthur Schulz: Molecular Biology of Human Cancers

Lectures

1 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

2 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

3 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,

cell protection mechanisms

Dr. Pandur Edina

4 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,

cell protection mechanisms

Dr. Pandur Edina

5 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and

tissue homeostasis

Jánosa Gergely

6 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and

tissue homeostasis

Jánosa Gergely

7 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina

8 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina



108

9 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,

replicative senescence and its disturbances in human cancers

Pap Ramóna

10 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,

replicative senescence and its disturbances in human cancers

Pap Ramóna

11 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

12 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

13 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling

during tumor invasion; angiogenesis.

Dr. Pandur Edina

14 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling

during tumor invasion; angiogenesis.

Dr. Pandur Edina

15 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Pap Ramóna

16 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Pap Ramóna

17 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

18 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

19 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Pap Ramóna

20 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Pap Ramóna

21 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Jánosa Gergely

22 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Jánosa Gergely

23 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

24 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

25 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

26 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

27 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Fliszár-Nyúl Eszter

28 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Fliszár-Nyúl Eszter

Practices

Seminars


Simple choice test based on the lectures.

Participants



109

OPE-DM1-T DEMONSTRATOR ACTIVITY 1

Course director: DR. LÁSZLÓ JÓZSEF CZOPF, associate professor

1st Department of Internal Medicine [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 3



Topic

This course gives support and acknowledgement for students performing documented and successful supervised teaching activities and

taking an active part in organizing courses.

The subjects can be taken up in eight semesters (in a total value of 16 credits).


Students have to register every semester as demonstrators, should provide proof of previous demonstrator activity, and the semester will

be signed on the basis of at least 24 hours of teaching or organizatory activity. The grades will be given according to the Code of

Demonstrators with additional requirements, that you can reach using the following links: Code of Demonstrator Students:

https://docs.google.com/document/d/1xkkyeRdZcDphnqWEkpON0SQf34MpBBJqogG09foI8Rw/edit?usp=sharing

Faculty Home Page of the Circle of Demonstrator Students (DDK):

http://aok.pte.hu/en/egyseg/almenu/980/339

Mid-term exams

At least two midsemester tests should be successfully completed to pass.


There are no absences accepted from the 24 hours demonstrator activity.

Reading material



..

- Notes


Lectures

Practices

Seminars


The topics of the tests depend on the specific course of the demonstrator activity.

Participants

Dr. Czopf László József (BAVD1M), Dr. Koppán Ágnes Judit (ZAEQDO), Dr. Sebők Judit (GLM10L), Dr. Tamás Andrea (F7QM8G),

Dr. Ujvári Balázs (EN1LY9)





110

OPE-WMI-T WEAK MOLECULAR INTERACTIONS





Course headcount limitations (min.-max.): 2 – 12 Prerequisites: OPA-GC1-T completed

Topic

The complex biochemical equilibria in living bodies as reversible chemical reactions are based on a series of weak molecular interactions.

Those interactions are playing very important role in the transfers of such bioactive molecules like the drugs and toxins. Further to this,

the weak molecular interactions also play important role in the molecular packing, molecular formulation of medicines. The weak

character of these interactions resulted that both the molecular environment and the temperature has high impact on these interactions.

The temperature itself affects the efficiency of drugs through affecting the transfer and the drug – target interactions. Therefore detailed

description of the temperature dependence of weak interactions is very important also in the associated therapies. Students will become

acquainted through several newest research results with the pharmaceutical applications of the processes listed above and with the

associated measuring methods and equipments.



Mid-term exams

One written exam during the semester, the acceptance level is 60%.


There is no possibility to make up for a missed lecture and practice

Reading material






- Notes


Atkins: Physical Chemistry I-III.


Lectures

1 Types of molecular interactions.


2 Types of molecular interactions.


3 Chemical equilibrium based on the weak molecular interactions.


4 Chemical equilibrium based on the weak molecular interactions.


5 Determination of the chemical equilibrium and the stoichiometry of the complexes.


6 Determination of the chemical equilibrium and the stoichiometry of the complexes.


7 Correlation between the chemical equilibrium and the free enthalpy.


8 Correlation between the chemical equilibrium and the free enthalpy.


9 Investigation of the weak interaction by measuring the fluorescence.


10 Investigation of the weak interaction by measuring the fluorescence.




111

11 Application of the Job’s method in the fluorescence measurements.


12 Application of the Job’s method in the fluorescence measurements.


13 Direct measuring the interaction enthalpy by differential scanning calorimetry.


14 Direct measuring the interaction enthalpy by differential scanning calorimetry.


15 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.


16 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.


17 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.


18 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.


19 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.






22 Controlling of self-assembly of some hormones by weak interactions.






25 Modifications of structure of serum albumins by molecular capsules. Interactions of molecular capsules with aromatic amino

acids at terminated positions.


26 Effect of Molecular Environment on the Formation Kinetics of Complexes of Malvidin-3-O-glucoside with Caffeic Acid and

Catechin


27 Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma

membranes.Complex formation between primycin and ergosterol: entropy - driven initiation of modification of the fungal plasma

membrane structure


28 Role of the Conformational Freedom of the Skeleton in the Complex Formation Ability of Resorcinarene Derivatives toward a

Neutral Phenol Guest


Practices

Seminars


Types of molecular interactions.

Chemical equilibrium based on the weak molecular interactions.

Determination of the chemical equilibrium and the stoichiometry of the complexes.

Correlation between the chemical equilibrium and the Gibbs free energy.

Investigation of the weak interaction by spectroscopical methods.

Application of the Jobs method in the fluorescence measurements.

Direct measuring the interaction enthalpy by differential scanning calorimetry.

Interactions of aromatic compounds.

Interactions of bioactive compounds with DNA.

Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.

Packing of drug molecules by molecular containers.

Interactions of bioactive molecules with elements of cell membranes.

Self-assembly of some hormones by weak interactions.



112

Participants

Dr. Kunsági-Máté Sándor (UYZM2Q)



113

OPE-TSS-T MEDICAL APPLICATIONS OF MASS SPECTROMETRY

Course director: DR. LÁSZLÓ MÁRK, associate professor






Topic

In medical sciences, emphasis is increasingly placed on instrumental techniques and accurate, quantitative measurements. This course is

give an overall review about the modern mass spectrometry and it shows the medical applications of the MS in the clinical and diagnostic

practice.

Topics:

Introduction to MS. Ionsources, analizators, detectors. Separation techniques. Sample handling. Biomedical sampling. Bioinformatics.

Proteomics, metabolomics and lipidomics. Biomarker discovery. Mass spectrometric imaging techniques.


Written exam. Max. absences: 20%.

Mid-term exams

Not possible.


Not possible.

Reading material



Lecture slides and notes.

- Notes


Vékey et al: Medical Applications of Mass Spectrometry, 2008.

Hoffman et al: Mass Spectrometry, 2007

Lectures

1 Introduction to mass spectrometry

Dr. Márk László

2 Introduction to mass spectrometry

Dr. Márk László

3 Ionsources

Dr. Márk László

4 Analyzers

Dr. Márk László

5 The mass spectrum.

Dr. Márk László

6 Sample matrices, Sampling procedures.

Dr. Márk László

7 Sample pretreatment, separation techniques.

Dr. Márk László

8 Sample pretreatment, separation techniques.

Dr. Márk László

9 Proteomics

Dr. Márk László

10 Proteomics

Dr. Márk László

11 Metabolomics

Dr. Márk László



114

12 Metabolomics

Dr. Márk László

13 Investigation of endocrine system

Dr. Márk László

14 Investigation of endocrine system

Dr. Márk László

15 Pathological biomarker discovery

Dr. Márk László

16 Pathological biomarker discovery

Dr. Márk László

17 Lipidomics

Dr. Márk László

18 Lipidomics

Dr. Márk László

19 Imaging mass spectrometry

Dr. Márk László

20 Imaging mass spectrometry

Dr. Márk László

Practices

Seminars


Ionsources.

Analizators.

Detectors.

Separation techniques.

Sample handling. Biomedical sampling.

Bioinformatics.

Proteomics.

Metabolomics

Lipidomics.

Biomarker discovery.

Mass spectrometric imaging techniques.

MS of endocrine system.

Participants



115

OPE-BEE-T BASICS OF EPIDEMIOLOGY






Topic

During the semester students are acquainted with the basics of epidemiology and epidemiological studies frequently used in scientific

literature. With this knowledge one can easily elucidate and interpret scientific publications.

This course was established especially for pharmacist and dentist students.



Mid-term exams

Examination: written test


Based on individual consideration

Reading material




- Notes


Lectures

1 The concept of epidemiology

Dr. Szabó István

2 The historical context

Dr. Szabó István

3 Epidemiology and public helath

Dr. Szabó István

4 Achievments in epidemiology

Dr. Szabó István

5 Measuring health and disease

Dr. Szabó István

6 Epidemiological studies

Dr. Szabó István


Dr. Szabó István


Dr. Szabó István

9 Potential errors in epidemiological studies

Dr. Szabó István

10 The concept of Evidence Based Medicine

Dr. Szabó István

11 Basic epidemiological calculations

Dr. Szabó István

12 Analyzis of selected scientific publications

Dr. Szabó István



116

Practices

Seminars


Neptun

Participants

Dr. Szabó István (BF4MF6)



117

OPE-EHS-T HUNGER, SATIETY AND DISTURBANCES OF BODY WEIGHT REGULATION

Course director: DR. LÁSZLÓ CSABA LÉNÁRD, professor emeritus




Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-Z2E-T completed + OPO-G2B-T completed

Topic

Based on recent results, feeding related physiological and pathophysiological mechanisms will be discussed. Students will be trained to

understand these mechanisms. The knowledge based on this course will highly contribute to better understanding further clinical studies

on human diseases.

Peripheral and central mechanisms of hunger, satiety, salt appetite and body weight regulation will be discussed. Lectures will include

the following topics: Neural and humoral processes. Peripheral and central glucose-monitoring system. The role of neuropeptides in the

control of feeding and hydromineral balance. Pathological processes: obesity, bulimia, anorexia.



Mid-term exams

Written exams.


Reading material



- Notes

Notes taken at the lectures.


Lectures

1 Basic parameters: caloric intake, energy expenditure, measurement of food and water intake, body weight and body mass index.

Body weight curves during development, adulthood and senescence.

Dr. Lénárd László Csaba

2 Peripheral and central mechanisms of body weight regulation.


3 Endocrine mechanisms: the role of different hormones.


4 Body weight loss, obesity. Long run pathological consequences of obesity.


5 Hunger and satiety. Motivational mechanisms. Overeating, rejection.


6 Hypothalamic dual centers. The role of limbic system in hunger and satiety.


7 Peripheral glucose related signals. The central glucose monitoring system.


8 Food rewarded learning, the role of reinforcement. Aversive learning, the role of conditioned taste aversion in feeding habits.


9 The sight, odor, taste and texture of foods and their detection in the limbic system. Ingestive and rejective mimetic responses and

their genetic determination. The role of monoamines in the regulation of feeding. Similarities of food rewarded learning and

addictive behavior. The role of dopamine and neuropeptides.


10 Orexigenic and anorexigenic neuropeptides.


11 The role of the central angiotensinergic system in drinking and hydromineral balance.


12 Childhood obesity and cognitive processes. Anorexia nervosa, bulimia and binge eating. Clinical relevance of animal experiments




118

Practices

Seminars


Nincsenek előre kreált kérdések, az utolsó előadás utolsó órájában a hallgatók az oktató által feltett kérdésekre kell esszét írnia

Participants



119

OPE-HL1-T ADVANCED PHYSIOLOGY 1






Topic

Discussion of physiological topics, that not belong to the core subject (based on real examples and case studies). The aim of the subject

is to understand the deep, advanced physiological knowledge and complete the core subject. That develops the problem-solving skills

necessary in the clinical practice and/or during scientific research. Furthermore, it can help to understand another subjects

(pathophysiology, pharmacology) based on physiology as well. The course can be useful for dentistry and pharmacy students as well,

since numerous topics are realted to dentistry or pharmacy as well. The course can contribute to the practical application of evidence

based medicine, as well as to interpret the (sometimes contradictory) scientific literature. Topics of the first semester: cell membrane,

muscle, blood, heart, circulation, respiration, gastrointestinal tract, metabolism, and renal functions.



Mid-term exams



Not necessary, but it is possible in another language.

Reading material



The slides will be available on PotePedia.

- Notes


Guyton and Hall: Textbook of Medical Physiology

Costanzo: Physiology Cases and Problems (Board Review Series)

Carroll: Problem-Based Physiology

Lectures

1 Evidence based medicine. The journey between observations and facts.

Dr. Ollmann Tamás

2 Homeostasis, fluid compartments, transport mechanisms. The case of the toxic lady.

Dr. Ollmann Tamás

3 Basics of neurophysiology. Membrane potential. Synapses. The importance of ions.

Dr. Ollmann Tamás

4 Autonomic nervous system. Is it better better to be afraid than to be frightened?

Dr. Ollmann Tamás

5 Molecular basics of muscle function. Significance of EMG in the recognition of diseases.

Dr. Ollmann Tamás

6 Metabolism of the muscle. Smooth muscle. The patient with a mysterious muscle weakness.

Dr. Ollmann Tamás

7 Composition of the blood. The significance of blood tests.

Dr. Ollmann Tamás

8 Erythrocytes and hemoglobin. From skin rashes to the bone marrow.

Dr. Ollmann Tamás

9 Leukocytes, immune system. Possible consequences of an insect bite.

Dr. Ollmann Tamás

10 Thrombocytes, coagulation. Tooth extraction and anticoagulants.

Dr. Ollmann Tamás

11 Blood types. The problematic of blood donation.

Dr. Ollmann Tamás



120

12 Cardiac rhythm and ECG. The patient with myocardial infarction-like symptoms.

Dr. Ollmann Tamás

13 Cardiac cycle and pumping function. The patient with heart failure.

Dr. Ollmann Tamás

14 Regulation of cardiac functions. Connection of decayed teeth and the heart.

Dr. Ollmann Tamás

15 Blood circulation. The patient with oedema. One sign, many possibilities.

Dr. Ollmann Tamás

16 Pulse and blood pressre. What can we do if we don’t have a sphygmomanometer?

Dr. Ollmann Tamás

17 Regulation of blood circulation. The fainting hunter.

Dr. Ollmann Tamás

18 Respiration, spirometry. Shortness of breath in the bathroom early in the morning.

Dr. Ollmann Tamás

19 The regulation of respiration. Difficulties of the alpinist.

Dr. Ollmann Tamás

20 Gastrointestinal tract. Toilet using habits. The relationship between gut flora and brain. The patient with abdominal pain.

Dr. Ollmann Tamás

21 Regulation of the gastointestinal functions. Digestion and absorption. Consuming too much alcohol.

Dr. Ollmann Tamás

22 Metabolism and thermoregulation. Healthy nutrition and fashionable diets. Facts and misbeliefs.

Dr. Ollmann Tamás

23 Renal functions. The urine and urination. The patient who cannot produce urine.

Dr. Ollmann Tamás

24 Volume and osmoregulation. pH regulation. The disadvantages of panic attacks.

Dr. Ollmann Tamás

Practices

Seminars



Participants



121

OPF-CME-T COMPUTATIONAL MOLECULAR ENGINEERING






Topic

Computational molecular engineering is a central, modern field of drug design. Theoretical and practical introduction is provided with

details of relevant softwares. In Journal Club sessions, recent research articles will be featured with the students to deepen their knowledge

in the areas discussed during the previous lectures. In this way, the students can discover further connections themselves and make sure

of the usefulness of their newly obtained knowledge in molecular engineering. The lectures will take place weekly or (if possible)

contracted into 4 blocks.



Mid-term exams






Reading material





- Notes


Lectures

1 Visualization of macromolecules. Programs VMD and PyMol

Dr. Hetényi Csaba

2 Structural measurements, editing and comparisons

Dr. Hetényi Csaba

3 An introduction to macromolecular structures. Main features of peptide and protein structures. Experimental sources of structural

data of biopolymers

Dr. Hetényi Csaba

4 Examples on structural variability. The role of conformational disorders of proteins in the pathomechanism of Alzheimer’s and

prion diseases. Myosin, the motor protein: same sequence with different structures

Dr. Hetényi Csaba

5 Surface and volume calculations

Dr. Hetényi Csaba

6 Simple methods for binding site detection and cavity search. Program PASS

Dr. Hetényi Csaba

7 Hierarchy of calculation methods. Fundamentals of QM

Dr. Hetényi Csaba

8 Programs for molecular modeling

Dr. Hetényi Csaba

9 Principles of molecular mechanics (MM). Force fields. Bonding and non-bonding interactions

Dr. Hetényi Csaba

10 The general algorithm of MM programs. Program packages. TINKER

Dr. Hetényi Csaba

11 Journal club 1. Computational methods and strategies of drug design

Dr. Hetényi Csaba

12 Journal club 2. Complementary approaches

Dr. Hetényi Csaba



122

Practices

Seminars



Participants



123

OPF-CY2-T CYBERNETICS FOR MEDICAL, DENTISTRY AND PHARMACY STUDENTS 2

Course director: LÁSZLÓ ZOLTÁN PÉCZELY, assistant professor





Topic

Cybernetics embracing more disciplines deals with the control, regulation, information flow and processing occuring in expediently

working dinamical systems. The most important goal of our subject is to help the students understand the functional principles of the

regulatory systems, mainly those of the human body. Furthermore, we would like to familiarize the students with how the balance of the

regulatory systems can be maintained by their wide adaptive and learning capacity/capability. We would like to demonstrate that etiology

of many diseases can be explained by the disruption of balance, how the balance can be restored by the therapy and, at the same time,

how the therapy can cause the shift of the balance in other parts of the system (side effect). In addition to the biological systems, both

the functional description of the artificial regulatory systems and the artificial intelligence will be addressed. In the second semester the

following topics are discussed: neuroendocrin regulation (II), nervous system and immune system as networks, integrative regulation of

motion, movement disorders, learning in artificial and biological systems, models of psychiatric diseases, regulatory disturbances.



Mid-term exams



Not necessary, but it is possible in another language

Reading material



- Notes


Guyton & Hall: Textbook of Medical Physiology

V. V. Purin, R. M. Buyevskiy: Introduction To Medical Cybernetics

Peter Norvig, Stuart J. Russell: MI modern megközelítésben

James Kneer, James Sneyd: Mathematical Physiology I.: Cellular Physiology

James Kneer, James Sneyd: Mathematical Physiology II.: System Physiology

Lectures

1 Networks: communication among cells, organs, organ systems; principles. Nested hierarchical systems.


2 Networks: nervous system (neuroendocrine system) and immune system, interactions, regulatory disturbances.


3 Detection in living organisms and artificial systems.


4 System-level description of the integrative regulation of motion, models, regulatory disturbances and their restitution.


5 Behaviour and motivation: high-level organization to maintain the integrity of the organism.


6 Mathematical models of adaptation, learning I : supervised and non-supervised learning in artificial systems.


7 Mathematical models of adaptation, learning II : supervised and non-supervised learning in biological systems.


8 Mathematical models of adaptation, learning III: reinforcement learning in artificial systems.


9 Mathematical models of adaptation, learning IV: reinforcement learning in biological systems.


10 Modeling of psychiatric diseases, regulatory disturbances, options for interventions I



124


11 Modeling of psychiatric diseases, regulatory disturbances, options for interventions II


12 Adaptation on the level of evolution: learning of species.


Practices

Seminars


The topics of the lectures

Participants



125

OPF-CSU-T MIRACLES OF LIVING MATERIALS ("REALISTIC" BIOCHEMISTRY)

Course director: DR. BALÁZS VERES, associate professor






Topic

The aim of the course is to enlighten and uncover the biochemical background of those topics which are selected as recent „mainstream”

natural science issues. The topic spectrum is wide enough to cover problems from synthetic biology through dopes in sport until toxins

and poisons of plants, fungi and animals. There is a special session about the physical, chemical and medical Nobel prizes from the last

decade to get insight to the hottest fields of natural sciences.



Mid-term exams

Hand-made info-graph about a selected topic.


There is no possibility to make up.

Reading material



Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.

- Notes




Lectures

1 Human genome project, gene therapy, epigenetics

Dr. Veres Balázs

2 DNA sequencing, PCR, CSI

Dr. Veres Balázs

3 Playing God: synthetic biology

Dr. Veres Balázs

4 Personalized genome-based medicine: access to a healthier world.

Dr. Veres Balázs

5 Superman: doping in sport and brain doping

Dr. Veres Balázs

6 Eugenics: the scientific horror of the XX. century.

Dr. Veres Balázs

7 Artificial life. The future of life forms - including humans - on Earth.

Dr. Veres Balázs

8 Cancer, AIDS: beyond therapy

Dr. Veres Balázs

9 Biochemistry of neurodegenerative disorders

Dr. Veres Balázs

10 Antibiotics: past, present, future

Dr. Veres Balázs

11 Home delivery: nanoparticles, liposomes

Dr. Veres Balázs

12 Nature strikes back: toxins of plants, fungi and animals



126

Dr. Veres Balázs

Practices

Seminars


Exam topics are the topics of the lectures during the course.

Participants



127

OPF-DR2-T DRUG DESIGN 2






Topic

The course is a continuation of its parent course Drug Design. Additional details of selected topics of the parent course and also new

topics are provided. In Journal Club sessions, recent research articles will be featured with the students to deepen their knowledge in the

areas discussed during the previous lectures. In this way, the students can discover further connections themselves and make sure of the

usefulness of their newly obtained knowledge in drug design. The lectures will take place weekly or (if possible) contracted into 4 blocks.



Mid-term exams






Reading material





- Notes


Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press

Lectures

1 Rational design: main concepts, phases, and techniques

Dr. Hetényi Csaba

2 Target-based optimization. Case study: ACE inhibitors

Dr. Hetényi Csaba

3 Ligand libraries, combinatorial synthesis, screening, modifications, and the pharmacophore. Case study: Artemisinin

Dr. Hetényi Csaba

4 Antiviral design

Dr. Hetényi Csaba

5 Antibacterial design

Dr. Zsidó Balázs Zoltán

6 Targeting ion channels


7 Targeting receptors 1.


8 Targeting receptors 2.


9 Targeting the signaling pathways


10 Journal club 1. Mechanisms and ligand optimizations

Dr. Hetényi Csaba

11 Journal club 2. Anti-cancer agents and ion channels

Dr. Hetényi Csaba

12 Test

Dr. Hetényi Csaba



128

Practices

Seminars



Participants



129

OPF-ESP-T EXERCISE AND SPORT PHYSIOLOGY

Course director: DR. PÉTER KÓBOR, assistant professor




Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-H1E-T completed

Topic

These days, it is apparent in almost every age group that the number of people dedicated to healthy lifestyle (including physical exercise)

is increasing. Simultaneously, the list of sport activities available in the university is expanding as well, consequently there are more and

more students doing sports on an amateur or higher level. Primary aim of this course is to unfold the exercise- and sports-related aspects

of physiology that have not been discussed during the regular physiology class, however these facts might be not only fascinating for

students involved in sport activities or treatment of athletes later on but they have very important theoretical and practical significance

as well.



Mid-term exams

Multiple choice test on the last lecture.


It is not necessary but possible in other language (Hungarian).

Reading material



Lecture slides will be provided for the students.

- Notes


Terry J. Housh, Dona J. Housh & Herbert A. deVries - Applied exercise and sport physiology with labs

William D. McArdle, Frank L. Katch & Victor L. Katch - Exercise physiology (Nutrition, energy, and human performance)

Lectures

1 Active and passive organs of moving

Dr. Kóbor Péter

2 The blood and the cardiovascular system

Dr. Kóbor Péter

3 Respiration

Dr. Kóbor Péter

4 Metabolism

Dr. Kóbor Péter

5 Water homeostasis, kidney function

Dr. Kóbor Péter

6 The nervous system

Dr. Kóbor Péter

7 The endocrine system

Dr. Kóbor Péter

8 The immune system

Dr. Kóbor Péter

9 Applied sport physiology 1 (division of physical exercises, physiological aspects of training, doping)

Dr. Kóbor Péter

10 Applied sport physiology 2 (improving endurance, speed, flexibility)

Dr. Kóbor Péter

11 Health benefits of physical activity

Dr. Kóbor Péter

12 Test writing

Dr. Kóbor Péter



130

Practices

Seminars


The topics are matching with those of the lectures.

Participants



131

OPF-GMI-T DAILY ROUTINE AND CHALLENGES IN VARIOUS FIELDS OF THE PHARMACY PROFESSION






Topic

This course intends to provide insight into various career opportunities for graduates with a degree in pharmacy. Invited speakers working

in various fields of the pharmaceutical profession talk about characteristic features of their job, including daily routine, challenging

situations and peculiarities they have come accross. Speakers represent pharmacists working in community pharmacies, clinical

pharmacies, in the pharmaceutical industry, as well as at health authorities and at universities or research institutes.



Mid-term exams

Active participation is expected from students. They should be prepared to ask questions from each speaker and they are requested to

take notes on each occasion. These notes should be handed in to the course instructor at the end of each class.

The final grade is based on student activity in class and the written notes they have taken on each occassion.


There is no opportunity to make up for absences, since different speakers are invited to each class.

Reading material


None


- Notes


Lectures

1 Invited speaker. Pharmacist at a community pharmacy.

Dr. Farkas Ágnes

2 Invited speaker. Pharmacist at a community pharmacy.

Dr. Farkas Ágnes

3 Invited speaker. Pharmacist at a clinical pharmacy.

Dr. Lankó Erzsébet

4 Invited speaker. Pharmacist at a clinical pharmacy.

Dr. Lankó Erzsébet

5 Invited speaker. Pharmacist working in the pharmaceutical industry.

Dr. Farkas Ágnes

6 Invited speaker. Pharmacist working in the pharmaceutical industry.

Dr. Farkas Ágnes

7 Invited speaker. Pharmacist working at a university.

Dr. Poór Miklós

8 Invited speaker. Pharmacist working at a university.

Dr. Poór Miklós

9 Invited speaker. Pharmacist working in a research institute.

Dr. Farkas Ágnes

10 Invited speaker. Pharmacist working in a research institute.

Dr. Farkas Ágnes

11 Invited speaker. Pharmacist working at the health authorities.

Dr. Kuzma Mónika

12 Invited speaker. Pharmacist working at the health authorities.

Dr. Kuzma Mónika



132

13 Invited speaker. Daily routine of a specialty pharmacist.

Dr. Szabóné Dr. Schirm Szilvia

14 Invited speaker. Daily routine of a specialty pharmacist.

Dr. Szabóné Dr. Schirm Szilvia

Practices

Seminars


No exam questions.

Participants



133

OPF-H4A-T MEDICAL HUNGARIAN 4A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY






Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing

medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.



Mid-term exams

--



Reading material



Hand-outs

- Notes


Lectures

Practices

Seminars

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: pain relievers

4 Instructions concerning the use of medications: pain relievers

5 Instructions concerning the use of medications: antipyretics

6 Instructions concerning the use of medications: cough medications

7 Instructions concerning the use of medications: antidiabetics

8 Instructions concerning the use of medications: spasmolytics

9 Instructions concerning the use of medications: sleeping pills

10 Instructions concerning the use of medications: steroids

11 Instructions concerning the use of medications: antibiotics

12 Instructions concerning the use of medications: antiinflammatory medications

13 Instructions concerning the use of medications: emetics and antiemetics

14 Instructions concerning the use of medications: eye, ear and nasal drops

15 Instructions concerning the use of medications: medications applied to the skin

16 Test 1

17 Instructions concerning the use of medications: suppository

18 First aid instruments

19 Preparation for the Final Exam in Medical Hungarian





24 Test 2. Course evaluation



134



Participants








135

OPF-H4B-T MEDICAL HUNGARIAN 4B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY






Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing

medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.



Mid-term exams



Reading material



Hand-outs

- Notes


Lectures

Practices

Seminars

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: pain relievers - Pharmacist-patient dialogues

4 Instructions concerning the use of medications: pain relievers- Pharmacist-patient dialogues

5 Instructions concerning the use of medications: antipyretics- Pharmacist-patient dialogues

6 Instructions concerning the use of medications: cough medications- Pharmacist-patient dialogues

7 Instructions concerning the use of medications: antidiabetics- Pharmacist-patient dialogues

8 Instructions concerning the use of medications: spasmolytics- Pharmacist-patient dialogues

9 Instructions concerning the use of medications: sleeping pills- Pharmacist-patient dialogues

10 Instructions concerning the use of medications: steroids- Pharmacist-patient dialogues

11 Instructions concerning the use of medications: antibiotics- Pharmacist-patient dialogues

12 Instructions concerning the use of medications: antiinflammatory medications- Pharmacist-patient dialogues

13 Instructions concerning the use of medications: emetics and antiemetics- Pharmacist-patient dialogues

14 Instructions concerning the use of medications: eye, ear and nasal drops- Pharmacist-patient dialogues

15 Instructions concerning the use of medications: medications applied to the skin- Pharmacist-patient dialogues

16 Test 1

17 Instructions concerning the use of medications: suppository- Pharmacist-patient dialogues

18 First aid instruments






24 Test 2. Course evaluation






136

Participants







137

OPF-HB2-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 2

Course director: DR. BALÁZS BOGNÁR, assistant professor




Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-S1E-T completed + OPA-S2E-T parallel

Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Revision of addition and substitution reactions

2. Basicity and reactivity of amines

3-4. Reactions of carbonyl compounds, nucleophilic additions, condensations

5. Isomerisations in carbohydrates

6. 1. test

7. Acidity of carboxylic acids

8. Reactions of carboxylic acids and their derivatives

9. Aromatic substitutions of heteroaromatics

10. 2. test



Mid-term exams

Nincs.


Nincs.

Reading material



The worksheets will be granted on the seminar.

- Notes


Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994.

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007.

Lectures

Practices

Seminars

1 Revision of the most important reaction mechanisms from the 1. semester: addition and substitution reactions.

Dr. Bognár Balázs

2 Basicity, synthesis and reactions of amines.

Dr. Bognár Balázs

3 Reactions of carbonyl compounds, nucleophilic additions, condensations with S,- N,- O-nucleophiles.

Dr. Bognár Balázs

4 Reactions of carbonyl compounds, nucleophilic additions, condensations with C-nucleophiles.

Dr. Bognár Balázs

5 Isomerisations and reactions in carbohydrates.

Dr. Bognár Balázs

6 1. test: amines, aldehydes, ketons, carbohydrates.

Dr. Bognár Balázs



138

7 Acidity and reactions of carboxylic acids.

Dr. Bognár Balázs

8 Reactions of carboxylic acids and their derivatives (amides, esters anhydrides).

Dr. Bognár Balázs

9 Aromatic nucleophilic and electrophilic substitutions of heteroaromatics.

Dr. Bognár Balázs

10 2. test: carboxylic acids and its derivatives, heterocycles.

Dr. Bognár Balázs


There is no exam.

Participants

Dr. Bognár Balázs (U34DM4)



139

OPF-HFG-T GREAT DISCOVERIES IN PHARMACOLOGY

Course director: DR. KRISZTINA HARNTNER-POHÓCZKY, assistant professor

Department of Pharmacology [email protected]




Topic

The aim of the lectures is to show how and through what discoveries pharmaceutical science came to today's modern age. Thanks to the

famous scientists presented their achieved breakthroughs in their own age have fundamentally changed scientific thinking. Pharmacology

has a rich and long-standing heritage, which today completed with new disciplines such as molecular biology and genetics, which provide

powerful tools for study pharmacodynamics and pharmacokinetics. During the semester, students will gain insight into the

pharmacological methods in those ages when researchers achieved their world-famous discoveries without today’s sophisticated tools.



Mid-term exams

During the semester, each student have to give a short presentation on a chosen topic related to drug discovery.


There is no possibility to make up the lectures.

Reading material



Own educational material will be available in digital form in the Neptun Meet Street.

- Notes


Ronald P. Rubin: A brief history of great discoveries in pharmacology: in celebration of the centennial anniversary of the founding

of the american society of pharmacology and experimental therapeutics, 2007: Pharmacological Reviews 59: 289-359.

Lectures

1 Important principles of drug treatments: Sir James Black, Gertrude Elion és és Geroge Hitchins.

Hartnerné Dr. Pohóczky Krisztina

2 Discoveries of János Kabay.


3 The discovery of penicillin and its curative effects in various infectious diseases: Sir Alexander Fleming, Cecil Paine, Harold

Raistrick, Ernst Chain, and Sir Howard Florey.


4 The scientific impact of Antal Bayer.


5 The roles of prostaglandins and related biologically active substances: Sune Bergstrom, Bengt Samuelsson, and John Vane.


6 Richter Gedeon and the kalmopyrin.


7 Discovery of cyclic AMP and protein phosphorylation as a key mechanism in the regulation of cellular function: Earl W.

Sutherland, Edwin G. Krebs and Edmond H. Fischer.


8 Career and research of Albert Szent-Györgyi.


9 G proteins and their role in signal transduction: Rodbell and Alfred G. Gilman.


10 Life and researh of Louis Pasteur.


11 The history of chemotherapy: from the chemical weapons to Sydney Farber.

Dr. Szőke Éva

12 History of capsaicin research, discovery of capsaicin-sensitive sensory nerve endings and their role: Miklós Jancsó and János

Szolcsányi.



140

Dr. Szőke Éva

13 Nitric oxide as a signaling molecule of the cardiovascular system: Robert Furchgott, Ferid Murad és Louis Ignarro.


14 József Béres; inventor and scientist.


Practices

Seminars


The final mark will based on the short oral presentation of a famous discovery or famous researcher.

Participants



141

OPF-QBI-T QUANTUM BIOLOGY: QUANTUM PHENOMENA IN BIOLOGICAL PROCESSES

Course director: DR. KRISZTIÁN KVELL, associate professor




Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-G2B-T completed

Topic

Course description:

Based on common scientific approach quantum phenomena are not relevant in biological processes. The living cell has relatively large

dimensions, is filled with hydrated vibrating macromolecules, and follows the rules thermodynamics rather than quantum mechanics.

Yet, besides attractive theories, experimental data also accumulate suggesting that living cells readily exploit quantum phenomena.

Several biological processes require quantum biology approach for full understanding. These include photosynthesis, various enzyme

activities, DNA mutation accumulation, avian magnetoreception, mammalian olfaction etc. During the course students get familiar with

the quantum biology explanation of these biological processes.



Mid-term exams

There will be several occasions for the students to rewrite midterm tests.


Students will get e-learning material to cope to follow the course at home.

Reading material


Life on the edge: The coming of age of quantum biology, Johnjoe McFadden, Jim Al-Khalili, Broadway Books (2016) 368 pages,

ISBN-13: 978-0307986825


Topics:

- Quantum phenomena and basics terms

- Thermodynamics vs quantum mechanics

- Structural characteristics of biological macromolecules

- Quantum biology approach of the living cell

- Quantum biology approach of cell death

- Quantum biology approach of molecular energy transport

- Quantum biology approach of genetic mutation accumulation

- Quantum biology approach of photosynthesis

- Quantum biology approach of enzyme activity

- Quantum biology approach of avian magnetoreception

- Quantum biology approach of mammalian olfaction

- Quantum biology approach of the conscious mind

- Basic principles of quantum computers and quantum biology analogies

- Written exam

- Notes


ISBN-13: 978-0307986825



ISBN-13: 978-0307986825

Lectures

1 Quantum phenomena and basics terms I.


2 Quantum phenomena and basics terms II.




142

3 Thermodynamics vs quantum mechanics I.


4 Thermodynamics vs quantum mechanics II.


5 Structural characteristics of biological macromolecules I.


6 Structural characteristics of biological macromolecules II.


7 Quantum biology approach of the living cell I.

Dr. Buzás Péter

8 Quantum biology approach of the living cell II.

Dr. Buzás Péter

9 Quantum biology approach of cell death I.

Dr. Buzás Péter

10 Quantum biology approach of cell death II.

Dr. Buzás Péter

11 Quantum biology approach of molecular energy transport I.

Dr. Pál Szilárd

12 Quantum biology approach of molecular energy transport II.

Dr. Pál Szilárd

13 Quantum biology approach of genetic mutation accumulation I.


14 Quantum biology approach of genetic mutation accumulation II.


15 Written exam


16 Quantum biology approach of photosynthesis I.

Dr. Hoffmann Gyula

17 Quantum biology approach of photosynthesis II.

Dr. Hoffmann Gyula

18 Quantum biology approach of enzyme activity I.

Dr. Pál Szilárd

19 Quantum biology approach of enzyme activity II.

Dr. Pál Szilárd

20 Quantum biology approach of avian magnetoreception I.

Dr. Hoffmann Gyula

21 Quantum biology approach of avian magnetoreception II.

Dr. Hoffmann Gyula

22 Quantum biology approach of mammalian olfaction I.

Dr. Hoffmann Gyula

23 Quantum biology approach of mammalian olfaction II.

Dr. Hoffmann Gyula

24 Quantum biology approach of the conscious mind I.

Dr. Sik Attila Gábor

25 Quantum biology approach of the conscious mind II.

Dr. Sik Attila Gábor

26 Basic principles of quantum computers and quantum biology analogies I.


27 Basic principles of quantum computers and quantum biology analogies II.


28 Written exam


Practices

Seminars


https://www.dropbox.com/home/munka/Kvantumbiológia?preview=LifeOnTheEdge2014.pdf

https://www.dropbox.com/home/munka/Kvantumbiológia?preview=LifeOnTheEdge2014.pdf



143

Participants

Dr. Ábrahám István Miklós (HQI9FH), Dr. Hoffmann Gyula (JB4TQB), Dr. Kvell Krisztián (Y0GLOV), Dr. Lukács András Szilárd

(LZ2I4Q), Dr. Miskei György Zsolt (PTAG3C), Dr. Pál Szilárd (FYF5E9), Dr. Sik Attila Gábor (A12OXW)



144

OPF-SKI-T BASICS OF CHEMICAL INFORMATICS

Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor




Course headcount limitations (min.-max.): 5 – 24 Prerequisites: OPA-S1E-T completed

Topic

The aim of the course is to give the students a basic knowledge of chemical informatics. An overview of how computers have become

the indispensable tools for chemical experiments, measurements, regulatory and performance evaluation tasks, and theoretical chemistry

tests.

We cover the chemical sciences from used software, web resources, which we believe are most useful during academic years in chemical

science student work and in preparing theses. Students can learn the basics of molecular modeling, the use of databases available in the

University (ScienceDirect, PubMed, SciFinder ...), the general steps of the search.



Mid-term exams

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.

Maximum three absences can be accepted.



Reading material



The worksheets will be handed on the seminars.

- Notes


https://docs.chemaxon.com/display/docs/MarvinSketch+User%27s+Guide

http://www.cambridgesoft.com/support/DesktopSupport/Documentation/Manuals/files/chemdraw_9_english.pdf

Lectures

1 Introduction, simple database managers (literature, citations, etc.) in chemistry.


2 Introduction into the Molecular Modeling Software”s


3 Molecular modeling - structural fundamentals


4 Molecular modeling - structure optimization


5 Molecular modeling - molecules and interaction with the surroundings


6 Molecular modeling - molecular Interactions


7 Molecular modeling - applied modeling in drug research


8 Chemical databases I.


9 Chemical databases II.


10 Using a text editor application in chemistry


11 Handling bibliography


https://docs.chemaxon.com/display/docs/MarvinSketch+User%27s+Guide

http://www.cambridgesoft.com/support/DesktopSupport/Documentation/Manuals/files/chemdraw_9_english.pdf



145

12 Apply a spreadsheet program in chemistry


13 Apply a vector drawing program. Creating a flowchart of science, chemical content and flow charts. Photos and videos in

chemistry, the basics of image processing.


14 Presentation of student results, evaluation of the semester


Practices

Seminars


Written test covering the topics of the lectures.

Participants



146

OPF-TG2-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 2





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG1-T completed

Topic



Research Society.



further semesters.

The prerequisite of this course (TDK 2): registration of the student in the database of Students’ Research Society and the fulfillment of

the Student Project Research for Students of Pharmaceutist Programme 1 course.

Mid-term exams

TG2

- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of

the semester.

- Written report on the work performed by the student. It must be sent to the course supervisor at the end of 13th week of the semester.

- Among the two conditions, one of them should be made at least.



Reading material



- Notes



Lectures

Practices

Seminars


Not applicable.

Participants




147

OPF-VAN-T IRON METABOLISM: FROM MOLECULAR MECHANISMS TO CLINICAL CONSEQUENCES

Course director: DR. EDINA PANDUR, assistant professor





Topic

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the

role of iron in the protective mechanisms against bacterial infections. We will discuss the possibilities of iron uptake and intracellular

iron utilistaion, especially heme synthesis, and the syntesis of iron-sulfur clusters. The iron storage and iron mobilization from stores will

be discussed in details. We reveal the functions of iron regulatory factors, their crosstalks, and the functions of the iron-containing

proteins. Based on the brand new literature we discuss the the positive and negative regulators of the master iron regulator hepcidin.

During the course we will deal with the different types of iron disorders and diseases (anemias, thalassemias, secondary iron overload,

hemochromatosis) their genetic background, and therapeutic approaches. Based on the most actual findings the role of iron in the

developpment of neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease and Huntington’s disease) will be also discussed.



Mid-term exams

One midterm exam, one possibility for retake.


Personal consultation

Reading material



The lectures will be uploaded to the Neptun Meet street.

- Notes


Robert Crichton: Iron metabolism 4th Edition

Sarika Arora: Iron metabolism

Lectures

1 Solution chemistry of iron

Jánosa Gergely

2 Interactions between iron other metal ions

Jánosa Gergely

3 The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins

Dr. Pandur Edina

4 Microbial Iron Transport and Metabolism

Jánosa Gergely

5 Iron Acquisition by pathogens

Jánosa Gergely

6 Iron metabolism of yeasts

Pap Ramóna

7 Iron uptake by plants

Dr. Pandur Edina

8 Iron homeostasis in plants

Dr. Pandur Edina

9 Cellular Iron Uptake and Export in Mammals: iron transporters

Dr. Pandur Edina

10 Mammalian intestinal iron absorption

Dr. Pandur Edina

11 Intracellular Iron Storage



148

Dr. Pandur Edina

12 Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism

haem biosynthesis

Pap Ramóna

13 Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clusters, functions of iron responsive

elements and iron regulatory proteins

Pap Ramóna

14 Regulation of Systemic Iron Metabolism: positive regulators of hepcidin

Dr. Pandur Edina

15 Regulation of Systemic Iron Metabolism: negative regulators of hepcidin

Dr. Pandur Edina

16 Pathophysiology of Iron metabolism: anemias (IDA, IRIDA, ACD)

Pap Ramóna

17 Pathophysiology of Iron metabolism: thalassemias and secondary iron overload

Jánosa Gergely

18 Pathophysiology of Iron metabolism: hemochromatosis

Dr. Pandur Edina

19 Pathophysiology of Iron metabolism: therapeutic approaches

Pap Ramóna

20 Iron disorders and Laboratory parameters 1.

Dr. Pandur Edina

21 Iron disorders and Laboratory parameters 2.

Dr. Pandur Edina

22 Iron and oxidative stress

Dr. Pandur Edina

23 Iron and immunity 1.

Pap Ramóna

24 Iron and immunity 2.

Pap Ramóna

25 Brain iron metabolism

Dr. Pandur Edina

26 The role of iron in neurodegenerative diseases

Dr. Pandur Edina

27 Iron and cancer 1.

Dr. Pandur Edina

28 Iron and cancer 2.

Dr. Pandur Edina

Practices

Seminars


The questions will be formed from the learning material of the lectures.

Participants



149

OPE-BKM-T BASIC METHODS OF SCIENTIFIC RESEARCH





Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-B2E-T completed + OPA-B2G-T completed

Topic

The course aims at introducing students to the basic steps of scientific research, guiding them through stages of becoming an independent

researcher. The course covers each step of the research process, from preparing a research plan to evaluating and reporting data. Students

will become familiar with various methods of literature search, data collection, data analysis, as well as the ethical questions of scientific

research. Students will be introduced to various types of scientific works, including rules and requirements of scientific communication.

A session will be dedicated to the special requirements of writing a thesis. Emphasis will be laid on practice: in the seminars students

should put into practice what they have learned in the lectures, based on their own research work.



Mid-term exams

Students will be required to perform some tasks related to their own research topic. The midsemester grade will be based on the successful

completion of the following tasks:

- literature search

- write a research plan

- prepare a questionnaire

- analyze data

- critically evaluate data, draw conclusions

- present results (oral and written format)


Students can make up for absences by completing the tasks and home assignments of each class.

Reading material



Lecture materials are available at the website of the Department of Pharmacognosy.

- Notes


Turabian K. L. (2010): A Manual for Writers of Research Papers, Theses, and Dissertations. Chicago Style for Students &

Researchers. 8th edition. The University of Chicago Press. Chicago and London, pp. 448.

Lectures

1 Concept, process and strategies of scientific research. Organising research projects.

Dr. Farkas Ágnes

2 Literature search

Dr. Farkas Ágnes

3 Writing a research plan. Designing experiments.

Dr. Farkas Ágnes

4 Methods of data collection. Questionnaires.

Dr. Farkas Ágnes

5 Data processing, data analysis.

Dr. Farkas Ágnes

6 Evaluation of data.

Dr. Farkas Ágnes

7 The role of informatics in scientific research.

Dr. Farkas Ágnes



150

8 The role of informatics in scientific research.

Dr. Farkas Ágnes

9 Ethical questions of scientific research.

Dr. Farkas Ágnes

10 Animal studies. Clinical studies.

Dr. Farkas Ágnes

11 Scientific communication. Types of scientific works. Metrics of scientific achievement.

Dr. Farkas Ágnes

12 Rules and requirements in scientific communication.

Dr. Farkas Ágnes

13 Writing applications for scholarships and research grants.

Dr. Farkas Ágnes

14 Scientific co-operations. Scene and institutions of science in Hungary.

Dr. Farkas Ágnes

Practices

Seminars

1 Literature search in the field of the student’s own research I.

Dr. Farkas Ágnes

2 Literature search in the field of the student’s own research II.

Dr. Farkas Ágnes

3 Preparing a research plan based on the student’s own research objectives.

Dr. Farkas Ágnes

4 Preparing a questionnaire

Dr. Farkas Ágnes

5 Evaluation of data from the student’s research project I.

Dr. Farkas Ágnes

6 Evaluation of data from the student’s research project II.

Dr. Farkas Ágnes

7 Practice of scientific communication I.

Dr. Farkas Ágnes

8 Practice of scientific communication II.

Dr. Farkas Ágnes

9 Practice of scientific communication III.

Dr. Farkas Ágnes

10 Practice of scientific communication IV.

Dr. Farkas Ágnes

11 Practice of scientific communication V.

Dr. Farkas Ágnes

12 Practice of scientific communication VI.

Dr. Farkas Ágnes

13 Practice of writing an application for a scholarship I.

Dr. Farkas Ágnes

14 Practice of writing an application for a research project II.

Dr. Farkas Ágnes


1. Research plan.

2. Methods of data collection.

3. Questionnaires.

4. Methods of literature search.

5. Methods of data analysis.

6. Critical evaluation of data.

7. Ethical questions of scientific research.

8. Animal studies. Clinical studies.

9. Scientific writing: types, rules and requirements.

10. References, bibliography.

11. Scene and institutions of science in Hungary.



151

Participants

Dr. Farkas Ágnes (DKQUBQ)



152






Course headcount limitations (min.-max.): 1 – 300 Prerequisites: OPE-DM1-T completed

Topic











Mid-term exams




Reading material



..

- Notes


Lectures

Practices

Seminars



Participants







153

OPE-GMO-T MODELLING THE STRUCTURE AND INTERACTIONS OF BIOACTIVE MOLECULES






Topic

Students will get deeper insights into the mechanisms of drug interactions at molecular level applying fundamental molecular modelling

methods. Further answering the scientific questions students will get skills to perform high quality figures and schemes of molecules and

molecular interactions to present their results and presentation content in lectures, diploma works or thesises. In this course the basic

examination methods of theoretical chemistry will be discussed by the practical point of view in the frame of following subtopics:

Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional methods, advantages and

disadvantages. Discovering the balance between the model ant the calculation methods. The algorithm of the choice of appropriate model

and calculation method. Short description of the basic rules and mathematical background of theoretical chemistry. calculation of the

electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the role of the entropy in the

interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and the temperature.

Examples at molecular level. Considering the molecular environment: explicit and implicit methods. Interesting examples and

applications in pharmacy.


There is no possibility to make up for a missed lecture

Mid-term exams

Two tests, each above 60 % is required for acceptance


Upto 15% is allowed, electronical material is available

Reading material


P.W. Atkins: Physical Chemistry




- Notes

Slides and Summaries of lectures are available electronically


Jensen_F.-Introduction_to_Computational_Chemistry_(2007)

Scientific papers, list will be given during the lectures

Lectures

1 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization

and related quantities (energy, momentum, spin). Simple mathematical descriptions.


2 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization

and related quantities (energy, momentum, spin). Simple mathematical descriptions.


3 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions

of the time - independent Schrödinger equation.


4 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions

of the time - independent Schrödinger equation.


5 3 lecture Approximative solutions: the molecular mechanics methods.


6 3 lecture Approximative solutions: the molecular mechanics methods.




154

7 4 lecture Semi - empirical methods, advantages and disadvantages.


9 5 lecture Conformation analysis, energy minimization algorithms.


11 6 lecture Electronic structure of molecules. The chemical bonds, tipes of bonds. The structure of molecules, stereochemistry.


13 7 lecture Modelling in comparison with the experiments, calculation of the enthalpy, entropy and their appropriate experimental

values.


15 8 lecture Molecular symmetry, point groups and the symmetry of molecular vibrations.


17 9 lecture Interactions of the primycin, ergosterol and oleic acid as plasma membrane unit.


19 10 lecture Modelling the interactions of bioactive molecules with molecular containers in accordance with molecular packing of

drugs.


21 11 lecture Quantum - chemical background of the rules in atomic and molecular spectroscopy. Rules of Raman and Infrared

transitions and their relationship with the molecular symmetry.


23 12 lecture Effective calculation methods to consider the molecular environment: Onsager-model, Polarizable Continuum Model


25 13 lecture Examples: simple chemical reactions, calculation of the stability weak molecular complexes, conformation analysis.


27 14 lecture Examples: modelling the systems possessing high symmetry and infinite volume. Crystals and polymers.


Practices

4 4 practice : Geometry optimization and conformation analysis. Energy minimization algorythm mostly used in geometry

optimization practice.


5 5 practice: Calculation of the static potential energy surfaces of chemical reactions. Methods to determine the transition states

associated to the chemical reactions. Activation energy and activation free enthalpy.


6 6 practice Molecular dynamics methods, Monte-Carlo method and the Langevin model. The implicite consideration of the

molecular environment.


7 7 practice Modelling the elementary chemical reactions. Calculation of molecular dynamics. Determination of the rection rate

using direct trajectory method.


8 8 practice Methods for consideration of the solvents: the Onsager-model, and the Polarizable Continuum Model, PCM. Explicit

consideration of the solvent molecules. The TIP3P model.


9 9 practice Calculation of molecular parameters have significant importance in the practice. The QSAR and the molecular

similarity - analysis.


10 10 practice Examples: conformation analysis, bong length, bond angle and dihedral angles. The bipyridile and thionine molecules.

Calixarenes and stereoisomers. Importance of hydrogen bonds in the stability of molecular geometries.


11 11 practice Examples: interactions of molecules. Calculation of the host - guest interactions, calculations of interactions of

calixarenes with neutral molecules based on pi-pi interactions.


12 12 practice Examples : elementary dissociation reactions: dissociation of asymmetric olefines. Effect of melecular environment

on the reaction rate.


13 13 practice Examples: Interaction of Primycin and oleic acid. Calculation of the interaction energy in system possessing large

numbers of electrons.


14 14 practice E+xamples: dynamic processes: modelling the crystal growth.




155

Seminars


Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional methods, avantages and

disadvantages. The balance between the model ant the calculation methods. The algorithm of the choice of appropriate model and

calculation method.Short description of the basic rules and mathematical background of theoretical chemistry. calculation of the

electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the role of the entropy in the

interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and the temperature.

Examples at moecular level. Considering the molecular environment: explicit and implicit methods. Interesting examples and

applications in pharmacy.

Participants

Dr. Kunsági-Máté Sándor (UYZM2Q)



156

OPE-SME-T SPECTROMETRIC IDENTIFICATION OF ORGANIC COMPOUNDS

Course director: DR. CECILIA PÁPAY-SÁR, associate professor





Topic

The aim of this course is to introduce the students how to identify organic compounds from the complementary information afforded by

three types of spectra: infrared, mass and NMR.



Mid-term exams

The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.


Students can personally consult with the lecturer.

Reading material


Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.


The ppt slides are uploaded to Neptun Meet Street.

- Notes


Lectures

Practices

Seminars

1 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra

Pápayné Dr. Sár Cecilia

2 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra


3 Infrared Spectroscopy: Characteristic group absorptions of organic molecules


4 Infrared Spectroscopy: Characteristic group absorptions of organic molecules


5 Infrared Spectroscopy: Solving problems


6 Infrared Spectroscopy: Solving problems


7 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation


8 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation


9 1H NMR: Chemical shift, simple spin coupling


10 1H NMR: Chemical shift, simple spin coupling


11 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center


12 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center


13 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI




157

14 1H NMR and 13 C NMR: Solving problems


15 Mass Spectrometry: Mass spectrometer parts, ionization processes

Dr. Kálai Tamás

16 Mass Spectrometry: Mass spectrometer parts, ionization processes

Dr. Kálai Tamás

17 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds

Dr. Kálai Tamás

18 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds

Dr. Kálai Tamás

19 Mass Spectrometry: Interpretation of the mass spectrum through examples

Dr. Kálai Tamás

20 Mass Spectrometry: Interpretation of the mass spectrum through examples

Dr. Kálai Tamás

21 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra






24 Evaluation, written test



Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.

Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin coupling, protons on

heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.

Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic

compounds.

Identification of simple organic molecules from IR, NMR and mass spectra.

Participants

Dr. Kálai Tamás (BDF5M9), Pápayné Dr. Sár Cecilia (BTYFJX)



158

OPE-HL2-T ADVANCED PHYSIOLOGY 2






Topic

Discussion of physiological topics, that not belong to the core subject (based on real examples and case studies). The aim of the subject

is to understand the deep, advanced physiological knowledge and complete the core subject. That develops the problem-solving skills

necessary in the clinical practice and/or during scientific research. Furthermore, it can help to understand another subjects

(pathophysiology, pharmacology) based on physiology as well. The course can be useful for dentistry and pharmacy students as well,

since numerous topics are realted to dentistry or pharmacy as well. The course can contribute to the practical application of evidence

based medicine, as well as to interpret the (sometimes contradictory) scientific literature. Topics of the second semester: endocrine

system, nervous system and sensory organs.



Mid-term exams



Not necessary, but it is possible in another language.

Reading material



The slides will be available on PotePedia.

- Notes


Guyton and Hall: Textbook of Medical Physiology

Costanzo: Physiology Cases and Problems (Board Review Series)

Carroll: Problem-Based Physiology

Lectures

1 Endocrine system. Hypophysis. The importance of balance.

Dr. Ollmann Tamás

2 Adrenal cortex. The unconscious cushingoid patient.

Dr. Ollmann Tamás

3 Adrenal medulla. Autonomic nervous system. The patient with too much stress.

Dr. Ollmann Tamás

4 Male sexual functions. The regulation of sexual behaviour. Differences from the average.

Dr. Ollmann Tamás

5 Female sexual functions. Birth. The mysterious symptoms of a young lady.

Dr. Ollmann Tamás

6 Thyroid gland. The case of the hyperactive child.

Dr. Ollmann Tamás

7 Calcium and phosphate. Physiology of the bone. The patient wiht muscle spasm.

Dr. Ollmann Tamás

8 Blood sugar level and diabetes. What should we take into consideration?

Dr. Ollmann Tamás

9 General properties of the nervous system. Peripheral nerv. Reflexes. Are we just a neural network?

Dr. Ollmann Tamás

10 Pyramidal system. From decortication to the spinal shock. The patient with stroke.

Dr. Ollmann Tamás

11 Extrapyramidal system. Parkinson, or not? Deep brain stimulation.

Dr. Ollmann Tamás



159

12 The cerebellum and being drunk.

Dr. Ollmann Tamás

13 The somatosensory system. How can we relieve pain?

Dr. Ollmann Tamás

14 The eye. Optics. The patient with blurred vision.

Dr. Ollmann Tamás

15 The retina and the visual pathway. Visual field defects.

Dr. Ollmann Tamás

16 The ear. The patient with vertigo.

Dr. Ollmann Tamás

17 Smell and taste. The patient who cannot recognize smells.

Dr. Ollmann Tamás

18 EEG, sleep. The doctor’s epileptic seizure.

Dr. Ollmann Tamás

19 Hypothalamus. Size doesn’t matter.

Dr. Ollmann Tamás

20 Limbic system. Motivations. Emotions. Play and addiction.

Dr. Ollmann Tamás

21 Monoamines. Schizophrenia. Autism and gut flora. The difficulties with pshychiatric medication.

Dr. Ollmann Tamás

22 Learning and memory. The patient wiht amnesia.

Dr. Ollmann Tamás

23 The functions of different areas of the brain. Effects of brain injury on personality and speech.

Dr. Ollmann Tamás

24 Brain research: from the rodents to the human. Addiction. The life of a clinician, scientific researcher and university lecturer.

Complex case study.

Dr. Ollmann Tamás

Practices

Seminars



Participants



160

OPE-TIZ-T CENTRAL REGULATION OF FEEDING AND METABOLISM. NEW APPROACHES

Course director: DR. ZOLTÁN KARÁDI, emeritus professor




Course headcount limitations (min.-max.): 2 – 25

Prerequisites: OPO-AI2-T completed + OPO-H1E-T completed + OPO-G1B-T parallel

Topic

The high incidence and costs of eating and metabolic disorders make it indispensable to experimentally test new theoretical

considerations, and to employ their conclusive results in basically new clinical protocols. Students at early stage of their studies are, thus,

encouraged to familiarize with new theoretical aspects and experimental findings.

Neural and humoral mechanisms in the central feeding control and metabolic regulation. Body weight control in health and disease.

Peripheral and central taste information processing; gustation in the central regulation of food and fluid intake. Obesity, diabetes mellitus

and the metabolic syndrome: New interpretations.


According to general regulations

Mid-term exams

Individual oral mid-semester test.


Individually discussed

Reading material


Guyton & Hall: Textbook of Medical Physiology, Saunders


- Notes


Williams and Pickup: Handbook of Diabetes, Blackwell

Doty: Handbook of Olfaction and Gustation, Marcel Dekker

Lectures

1 Physiological significance of food and fluid intake, and metabolism. Homeostasis, motivation.

Dr. Karádi Zoltán

2 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,

neuropeptides. I

Dr. Karádi Zoltán


neuropeptides. II

Dr. Karádi Zoltán


neuropeptides. III

Dr. Karádi Zoltán

5 Exogenous chemosensory modalities. Physiologic roles of gustation.

Dr. Karádi Zoltán

6 Central taste pathways, „labeled lines”, neurons.

Dr. Karádi Zoltán

7 Taste preference, taste aversion, palatability, flavour.

Dr. Karádi Zoltán

8 The glucose-monitoring (GM) neural network. I

Dr. Karádi Zoltán

9 The glucose-monitoring (GM) neural network. II

Dr. Karádi Zoltán

10 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. I

Dr. Karádi Zoltán



161

11 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. II

Dr. Karádi Zoltán

12 Feeding and metabolic disorders: disturbance of the GM system?

Dr. Karádi Zoltán

Practices

Seminars


1. Feeding (hunger) and satiety centers; feeding (hunger) and satiety neural pathways.

2. Orexigenic and anorexigenic neuromodulator factors (list up at least 3 of each).

3. The two major neuron types of the hypothalamic arcuate nucleus (with respect to feeding); their modulation by insulin, leptin, and

ghrelin.

4. Key structures of the central glucose-monitoring neuronal network (list up at least 4 of them).

5. Consequences of selective destruction of central GM neurons (name of the toxic agent, and its effects).

Participants



162

ATT5-T PHYSICAL EDUCATION 5

Course director: DR. ISTVÁN KARSAI, assistant professor

UP MS Sports Facilities [email protected]

0 credit ▪ signature ▪ Optional subject ▪ both semesters ▪ recommended semester: 5


Course headcount limitations (min.-max.): 2 – 50 Prerequisites: ATT4-T completed


Topic

This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to

deepen the knowledge in the field of healthy lifestyle.

Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and

how to prevent the body from injuries.



Mid-term exams


We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the

end of the teaching weeks with agreement of the PE Teacher.

Reading material



Not available.

- Notes


Lectures

Practices

1-28 For the list of actual courses please turn to the end of document for the obligatory subjects of the 1-2nd semester

Seminars


Participants

Farkas György (CL1MIY), Lipcsik Zoltán (EGE1AE), Németh Attila Miklós (EXB7TD), Téczely Tamás (P0OP8M)



163

OPF-GKG-T GAS CHROMATOGRAPHY

Course director: DR. VIKTÓRIA POÓR, assistant professor




Course headcount limitations (min.-max.): 4 – 15 Prerequisites: OPA-M1E-T completed

Topic

Key Topics

-practical theory about Gas Chromatography

-how to select and use the carrier gas

-various injection techniques and when to use each

-how to select a GC column

-the operation and selection of an appropriate GC detector

-how to write measuring methods

-how to undertake data analysis

-sampling techniques for GC

-strategies for method development

-introduction to GC & MS advanced techniques

-applications (pharmaceutical application)



Mid-term exams

1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical apllication)


There is no possibility for retake

Reading material


Modern Analytical Cheymistry,David Harvey


www.aok.pte.hu/bioanalitika

- Notes


Lectures

1 practical theory about Gas Chromatography

Dr. Poór Viktória

2 how to select and use the carrier gas

-various injection techniques and when to use each

Dr. Poór Viktória

3 how to select a GC column

-the operation and selection of an appropriate GC detector

Dr. Poór Viktória

4 strategies for method development

Dr. Poór Viktória

5 introduction to GC & MS advanced techniques

Dr. Poór Viktória

6 introduction to GC & MS advanced techniques

Dr. Poór Viktória

7 how to write measuring methods

Dr. Poór Viktória

8 how to undertake data analysis

Dr. Poór Viktória

http://www.aok.pte.hu/bioanalitika



164

Practices

1 GC practice 1

Dr. Poór Viktória

2 GC practice 2

Dr. Poór Viktória

3 GC-MS 1.

Dr. Poór Viktória

4 GC-MS 2.

Dr. Poór Viktória

Seminars


1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical apllication)

Participants

Dr. Poór Viktória (MJELTX)



165

OPF-GLK-T BIOINORGANIC CHEMISTRY FOR PHARMACY STUDENTS






Prerequisites: OPA-T2E-T completed + OPA-S2E-T completed + OPO-GE2-T parallel

Topic

We will provide an overview in this block about bioinorganic topics of chemistry, regarding the role of the different elements in medicinal

and pharmaceutical chemistry. Our aim is to offer a concise knowledge also about bioinorganic relations on medical contrast agents like

X-ray, tomographic, MR and ultrasound contrast agents. The use of radionuclids in diagnostical methods will be discussed too.



Mid-term exams

Students will have to write a written test at the end of the semester.


In case of absences the students must follow up with self-education!

Reading material



Lecture notes provided by the lecturer.

- Notes


Lectures

1 Introduction, The biological importance of non-metals and metals.

Dr. Huber Imre

2 An overview of the elements.

Dr. Huber Imre

3 Rtg-contrast agents.

Dr. Huber Imre

4 Watersoluble nephrothrop Rtg-contrast agents with high osmolality.

Dr. Huber Imre

5 Watersoluble nephrothrop Rtg-contrast agents with low osmolality.

Dr. Huber Imre

6 Watersoluble hepatothrop Rtg-contrast agents.

Dr. Huber Imre

7 Water-insoluble Rtg-contrast agents.

Dr. Huber Imre

8 Contrast agents for MRI.

Dr. Huber Imre

9 Contrast agents for CT.

Dr. Huber Imre

10 Contrast agents for ultrasound.

Dr. Huber Imre

11 Radioactive diagnostics (radionuclids).

Dr. Huber Imre

12 Platinum comlexes in medicin. Chelation therapy.

Dr. Huber Imre

13 Bisphosphonates in medicin.

Dr. Huber Imre

14 Geometry of complexes. Closing written test.

Dr. Huber Imre



166

Practices

Seminars


These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the

corresponding answers, parallely.

Participants



167

OPF-GMT-T DRUG METABOLISM AND DRUG TOXICITY

Course director: DR. ATTILA ALMÁSI, assistant professor





Topic

On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different

drugs are aimed, during the drug absorption, drug transformation and drug elimination.

During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.



Mid-term exams

In the end of the semester the students write an end-semester test. The test is evaluated in percentage and the final grade is to be established

based on this result. The result of the test should be above 60%.


The replacement of the missed test is required.

Reading material



Slides of the lectures.

- Notes


Lectures

1 Introduction. The toxicological aspects of drug metabolism.

Dr. Almási Attila

2 Characteristics of xenobiotics in the body

Dr. Almási Attila

3 Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes).

Dr. Almási Attila

4 Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations).

Dr. Almási Attila

5 Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation).

Dr. Almási Attila

6 Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione

conjugation).

Dr. Almási Attila

7 Phase III. transformations (transporters), general molecular mechanism of drug toxicity.

Dr. Almási Attila

8 Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol.

Dr. Almási Attila

9 Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac.

Dr. Almási Attila

10 Toxicity of the troglitazone. Sulfonamide hypersensitivity.

Dr. Almási Attila

11 Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis.

Dr. Almási Attila

12 Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens.

Dr. Almási Attila

13 Metabolic differences between species, genetic polymorphism.

Dr. Almási Attila

14 Changes in drug metabolism during pregnancy and at aged people.

Dr. Almási Attila



168

Practices

Seminars


Based on the announced thesis list.

Participants

Dr. Almási Attila (KJ5MBZ)



169

OPF-HKG-T INTERFACIAL CHEMISTRY IN PHARMACEUTICAL TECHNOLOGY






Prerequisites: OPA-PC2-T completed + OPA-KD1-T completed + OPG-C1E-T parallel

Topic

Based on the earlier colloid and physical chemistry studies, the course deals with the colloid systems, which are widely used in

pharmaceutical technology. After a short summary of general colloid and interfacial chemistry, we discuss about the most important

contemporaneous medicines and the modern pharmaceutics.



Mid-term exams

Participation on the seminars - accepted work reports - accepted written assessments Students have to write an end-semester assessment

from the lectures at acceptance level of 60%.


Students must fulfill requirements determined by the Code of Studies and Examinations. Student has to make up the missed lectures and

do work reports.

Reading material



- Notes


Duncan J. Shaw: Introduction to colloid and surface chemistry (Elsevier, 2013)

Vijay Kumar Thakur and Manju Kumari Thakur: Handbook of Polymers for Pharmaceutical Technologies (Wiley, 2015)

Tharwat F. Tadros: Colloid Stability and Application in Pharmacy ()

Lectures

1 Introduction to Pharmaceutical Technology

Vörös-Horváth Barbara

2 Introduction to Pharmaceutical Technology


3 Interfacial chemistry basics


4 Interfacial chemistry basics


5 Sols and suspensions in pharmaceutical technology


6 Sols and suspensions in pharmaceutical technology


7 Sols and suspensions in magistral medicines


8 Sols and suspensions in magistral medicines


9 Emulsions in pharmaceutical technology


10 Emulsions in pharmaceutical technology


11 Emulsions in magistral medicines


12 Emulsions in magistral medicines




170

13 Pickering emulsions in pharmacy


14 Pickering emulsions in pharmacy


15 Polymers in pharmaceutical technology I.








19 Solid dispersions in pharmaceutical technology


20 Solid dispersions in pharmaceutical technology


21 Aerosols and foams in pharmaceutical technology


22 Aerosols and foams in pharmaceutical technology


23 Associations colloids in pharmaceutical technology


24 Associations colloids in pharmaceutical technology


25 Pharmaceutical nanotechnology


26 Pharmaceutical nanotechnology


27 Written test

Dr. Pál Szilárd

28 Written test

Dr. Pál Szilárd

Practices

Seminars



Participants

Dr. Pál Szilárd (FYF5E9), Vörös-Horváth Barbara (QR6NGM)



171

OPF-HVS-T SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN THERAPY

Course director: DR. TAMÁS KÁLAI, professor





Topic

Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains

a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of

heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemisty 1 and Organic chemistry 2 course, discusses

those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.

-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds, Saturated heterocycles, occurence of heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms: imidazole, oxazole, thiazole

-Pyrazole, isoxazole, isothiazole

-I. st test, Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines, triazines etc.)

-Seven membered heterocyclic chemistry

-Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis

-II nd test, short presntation on a paper on heterocyclic chemistry

-Evaluation



Mid-term exams

The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a

presentation based on a heterocyclic chemistry paper for an extra grade.


Personal communication. The english program student might visit the paralell hungarian course to catch up the main reaction equations.

Reading material


Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley


Slides will be given to students as a ppt or pdf files.

- Notes

Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)


Li, J. J. Top 10 drugs Oxfors University Press

Lectures

Practices

Seminars

1 Electronic structure of heterocycles, nomenclature of heterocycles

Dr. Kálai Tamás

2 Occurence of heterocyclic compounds

Dr. Kálai Tamás

3 Synthesis of heterocycles



172

Dr. Kálai Tamás

4 Common reaction types in heterocyclic chemistry

Dr. Kálai Tamás

5 Tautomerism in heterocyclic chemistry

Dr. Kálai Tamás

6 Saturated heterocycles

Dr. Kálai Tamás

7 Three and four membered heterocycles, beta lactams

Dr. Kálai Tamás

8 Three and four-membered heterocycles and beta lactams

Dr. Kálai Tamás

9 Synthesis of pyrroles and porfirine ring containing compounds

Dr. Kálai Tamás

10 Synthesis of indoles, main reactions of indoles.

Dr. Kálai Tamás

11 Furans and thiophenes

Dr. Kálai Tamás

12 Thiophenes and benzothiophenes

Dr. Kálai Tamás

13 1,2-azoles, their synthesis, reactions and their occurence in drugs

Dr. Kálai Tamás

14 1,3-azoles, their synthesis, reactions, occurence in drugs

Dr. Kálai Tamás

15 1st test (generral feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles)

Dr. Kálai Tamás

16 Six membered heterocycles containing oxygen heteroatom

Dr. Kálai Tamás

17 Pyridines (synthesis, reactions, occurence in drugs and biomolecules)

Dr. Kálai Tamás

18 Quinolines, isoquinolines (synthesis, reactions, occurence in drugs)

Dr. Kálai Tamás

19 Synthesis of pyrimidines and their occurence in medicines

Dr. Kálai Tamás

20 Synthesis and reactions of 1,2- and 1,4-diazines

Dr. Kálai Tamás

21 Synthesis and reactions of triazines and purines

Dr. Kálai Tamás

22 Heterocycles of life and death

Dr. Kálai Tamás

23 Seven membered heterocycles their occurence, synthesis, applications in therapy

Dr. Kálai Tamás

24 IInd test, short presentations on papers on heterocyclic chemistry, evaluation

Dr. Kálai Tamás

25 Heterocycles in supramolecular chemistry

Dr. Kálai Tamás

26 Heterocycles in organic synthesis

Dr. Kálai Tamás

27 2nd test (6- and 7-membered heterocycles)

Dr. Kálai Tamás

28 Short presentations, evaluations

Dr. Kálai Tamás


-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds

-Saturated heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)



173

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms

-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)

-Seven membered heterocyclic chemistry

- Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis

Participants

Dr. Kálai Tamás (BDF5M9)



174

OPF-MEM-T HEALTH BENEFITS OF HONEY AND OTHER BEE PRODUCTS






Topic

Honey and other products of the beehive (e.g. propolis, royal jelly) have had an important role in preserving our health since ancient

times. Today there is growing interest towards various fields of apitherapy both from healthcare professionals and people who intend to

use a bee product to alleviate the symptoms of a disease or for prevention. The course provides an overview about various fields of

apitherapy, including the origin, types, physico-chemical characteristics and medicinal application of honey, propolis, royal jelly and bee

venom - based on recent scientific evidence. The course will cover the issues related to the adulteration and identification of honey. The

practice will focus on the analysis of various types of honey: the botanical origin of honey will be confirmed with microscopical pollen

analysis and measurement of physico-chemical parameters, while the antioxidant and antimicrobial activity of honey will be determined

with in vitro tests.



Mid-term exams

Students have to pass 2 written tests with at least 60% of good answers.

Students are required to prepare lab notes based on laboratory activities.


There is no possibility for making up for missed classes.

Reading material



Teaching materials (Power Point slideshows) will be available at the website of the Department of Pharmacognosy.

- Notes


The course will involve critical evaluation of recent literature sources (articles in scientific journals, book chapters, websites).

Lectures

1 Botanical and geographical origin of honeys.

Dr. Farkas Ágnes

2 Chemical composition of honey.

Dr. Farkas Ágnes

3 Honey types of Hungary (botanical origin, sensory analysis, physico-chemical properties).

Dr. Farkas Ágnes

4 Honey types worldwide (botanical origin, sensory analysis, physico-chemical properties).

Dr. Farkas Ágnes

5 Methods used in identification of honey samples. Honey adulteration.

Dr. Farkas Ágnes

6 Identifying honeys with microscopical pollen analysis.

Dr. Farkas Ágnes

7 Medicinal application of honey.

Dr. Farkas Ágnes

8 Antimicrobial effect of honey and propolis.

Dr. Farkas Ágnes

9 Other fields of apitherapy.

Dr. Farkas Ágnes

10 Other bee products with health benefits.

Dr. Farkas Ágnes



175

Practices

1 Sensory analysis of honeys.

Dr. Farkas Ágnes

2 Examination of physico-chemical properties of honeys.

Dr. Farkas Ágnes

3 Microscopical pollen analysis of honeys I.

Dr. Farkas Ágnes

4 Microscopical pollen analysis of honeys II.

Dr. Farkas Ágnes

5 Microscopical pollen analysis of honeys III.

Dr. Farkas Ágnes

6 Microscopical pollen analysis of honeys IV.

Dr. Farkas Ágnes

7 Measuring antioxidant capacity of honey samples I.

Dr. Kocsis Marianna

8 Measuring antioxidant capacity of honey samples II.

Dr. Kocsis Marianna

9 Measuring antioxidant capacity of honey samples III.

Dr. Kocsis Marianna

10 Measuring antioxidant capacity of honey samples IV.

Dr. Kocsis Marianna

11 Determining the antimicrobial effect of honey samples with in vitro assays I.

Magné Balázs Viktória Lilla

12 Determining the antimicrobial effect of honey samples with in vitro assays II.


13 Determining the antimicrobial effect of propolis with in vitro assays I.


14 Determining the antimicrobial effect of propolis with in vitro assays II.


Seminars


(1) Botanical and geographical origin of honey.

(2) Chemical composition of honey.

(3) Types of honeys in Hungary and abroad.

(4) Sensory analysis of honeys.

(5) Physico-chemical characteristics of different honey types.

(6) Methods for identifying various types of honey.

(7) Microscopic pollen analysis of honeys.

(8) Honey adulteration.

(9) Medicinal use of honey.

(10) Other fields of apitherapy.

(11) Other bee products with health benefits.

(12) Antioxidant activity of honeys.

(13) Antimicrobial effect of honey and propolis.

Participants

Dr. Farkas Ágnes (DKQUBQ), Dr. Kocsis Marianna (C9C3UN), Magné Balázs Viktória Lilla (B9FASU)



176

OPF-TS1-T CALCULATIONS IN PHARMACEUTICAL TECHNOLOGY 1





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C1E-T parallel + OPG-GI1-T completed

Topic

Aim of the course is to deepen the knowledge of calculations needed for Pharmaceutical Technology 1 practice (dose checking,

prescription reading and understanding) by solving and practicing several examples together with the course leader.



Mid-term exams




Students must fulfill requirements determined by the Code of Studies and Examinations. Student has to make up the missed lectures and

do work reports.

Reading material



Seminar notes.

- Notes


European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London


Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

Practices

Seminars

1 Introduction to pharmaceutical technological calculations, praciticing and understanding expressions found on prescriptions

Dr. Pál Szilárd

2 Concept of concentration

Dr. Kása Péter

3 Basic calculations of clear solutions (mixing rule)

Dr. Ferenczi Krisztina

4 Calculations of ethanol dilution

Dr. Kása Péter

5 Fundamentals of dose checking (understanding the prescription, syrup factor, elderly factor)

Dr. Pál Szilárd

6 Dose checking in solutions 1.

Dr. Kása Péter

7 Dose checking in solutions 2.

Dr. Pál Szilárd

8 Dose checking in peroral drops 1.

Dr. Kása Péter

9 Dose checking in peroral drops 2.

Dr. Kása Péter



177

10 Calculation of isotonicity 1.

Dr. Ferenczi Krisztina

11 Calculation of isotonicity 2.

Dr. Kása Péter

12 Test

Dr. Pál Szilárd



Participants

Dr. Ferenczi Krisztina (I8U2DJ), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)



178

OPF-VGG-T COLLECTING AND CONSERVATION OF WILD NATIVE MEDICINAL PLANTS

Course director: DR. DRAGICA PURGER, assistant professor




Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPO-G2E-T completed + OPO-G2G-T completed

Topic

Collecting and conservation of wild native medicinal plants is an elective course that will help in obtaining wider knowledge related to

medicinal plants. The topic covers wild medicinal plants native to Hungary, their morphological description, their occurrence and

significance. It describes in detail the methodology and possibilities for collecting wild medicinal plants in nature, and discusses strategies

for the conservation of rare and endangered herb species. The course includes a half-day field trip to Pécs-Nagyarpád, where the main

focus is on the recognition of native wild medicinal plants in nature. The students can broaden their knowledge related to wild medicinal

plants and their application in pharmacist practice.



Mid-term exams

Written test


Upon individual agreement. Field practices cannot be missed or made up for.

Reading material



- Notes


Shi Lin Chen et al. 2016: Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med 11:37

(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967523/pdf/13020_2016_Article_108.pdf)

Danna J. Leaman: Sustainable wild collection of medicinal and aromatic plants. Development of an international standard

https://library.wur.nl/frontis/medicinal_aromatic_plants/07_leaman.pdf

Medicinal Plant Specialist Group Species Survival Commission IUCN 2007: International Standard for Sustainable Wild Collection

of Medicinal and Aromatic Plants (ISSC-MAP) Version 1.0- The World Conservation Union

https://www.bfn.de/fileadmin/MDB/documents/service/skript195.pdf

Lectures

1 Importance of wild medicinal plants

Dr. Purger Dragica

2 Collection of wild medicinal plants in Hungary; historical overview

Dr. Purger Dragica

3 Methods of the collection of wild medicinal plants

Dr. Purger Dragica

4 Methods of the collection of wild medicinal plants

Dr. Purger Dragica

5 National and regional databases of wild medicinal plants

Dr. Purger Dragica

6 Collection Calendar

Dr. Purger Dragica

7 Primary processing of collected medicinal plants

Dr. Purger Dragica

8 Primary processing of collected medicinal plants

Dr. Purger Dragica

9 General quality requirements

Dr. Purger Dragica

10 General quality requirements

Dr. Purger Dragica

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967523/pdf/13020_2016_Article_108.pdf

https://library.wur.nl/frontis/medicinal_aromatic_plants/07_leaman.pdf

https://www.bfn.de/fileadmin/MDB/documents/service/skript195.pdf



179

11 International conventions and rules

Dr. Purger Dragica

12 International conventions and rules

Dr. Purger Dragica

13 Estimating the population size of medicinal plants

Dr. Purger Dragica

14 Estimating the population size of medicinal plants

Dr. Purger Dragica

15 Endangered, protected and strictly protected native medicinal plants

Dr. Purger Dragica

16 Endangered, protected and strictly protected native medicinal plants

Dr. Purger Dragica

17 Monitoring populations of threatened species

Dr. Purger Dragica

18 Monitoring populations of threatened species

Dr. Purger Dragica

19 Strategies for conservation of endangered medicinal plants

Dr. Purger Dragica

20 Strategies for conservation of endangered medicinal plants

Dr. Purger Dragica

21 The role of botanical gardens in ex situ preserving of medicinal plants

Dr. Purger Dragica

22 The role of botanical gardens in ex situ preserving of medicinal plants

Dr. Purger Dragica

23 Exam: Written test

Dr. Purger Dragica

24 Exam: Written test

Dr. Purger Dragica

Practices

1 General information on plant parts collected

Dr. Purger Dragica

2 The most important wild native medicinal plants in Hungary, their habitats and distribution

Dr. Purger Dragica

3 Collecting wild medicinal plants in the field

Dr. Purger Dragica

4 Collecting wild medicinal plants in the field

Dr. Purger Dragica

Seminars


1. Importance of wild medicinal plants

2. Collection of wild medicinal plants

3. Methods of the collection of wild medicinal plants

4. The most important wild native medicinal plants in Hungary

5. Collecting wild medicinal plants in the field

6. Collection Calendar

7. Primary processing of collected medicinal plants

8. General quality requirements

9. International conventions and rules

10. Estimating the population size of medicinal plants

11. Endangered, protected and strictly protected native medicinal plants

12. Monitoring populations of threatened species

13. Strategies for conservation of endangered medicinal plants

14. The role of botanical gardens in ex situ preserving of medicinal plants

Participants

Dr. Purger Dragica (FCCWBF)



180

OPE-EFA-T ETHNOPHARMACOBOTANY

Course director: DR. NÓRA PAPP, associate professor




Course headcount limitations (min.-max.): 4 – 20 Prerequisites: OPO-G1E-T completed + OPO-G2E-T completed


Topic

Several written sources are available on the ethnobotanical usage and pharmaceutical history of medicinal plants from the Ancient Times.

The course presents a summary about ethnobotanical data focusing on folk therapeutical methods and values of the Mediterranean area,

Transylvania, countries of Europe, Asia, America and Africa completed by the scientific activity and curriculum vitae of ethnobotanists

and researchers in this topic. Students receive a general approach about the rules and regularity of the special folk terminology, practice,

folk customs and symbols in consideration of medicinal plants. In addition to ethnobotanical methods, the actual state, position and

necessity of surveys are discussed during the course.


Satisfactory fulfilment of 2 written tests based on the lectures.

Absences: according to the Code of Studies and Examinations of the Medical School.

Mid-term exams

The required 2 tests can be retaken or corrected in the course.



Reading material






- Notes


Cunninham A. B.: Applied Ethnobotany. People, Wild Plant Use and Conservation, Earthscan, London, 2002

Ellen, Davi E., Hatfield, G.: Medicinal Plants in Folk Tradition an Ethnobotany of Britain and Ireland, Timber Press, Portland,

Cambridge, 2004

Lise Manniche: The Ancient Egyptian Herbal, The British Museum Press, London, 1989

Martin G. J.: Ethnobotany. A Methods Manual, Earthscan, London, 2007

Minnis P. E.: Ethnobotany. A Reader, University of Oklahoma Press, U.S.A., 2000

Moerman, Daniel E.: Native American Ethnobotany, Timber Press, Portland, London, 2010

Paye, Gabriell DeBear: Cultural Uses of Plants, The New York Botanical Garden Press, Bronx, New York, 2000

Lectures

1 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

2 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

3 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

4 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

5 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra

6 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra





181

7 Ethnopharmacological values of the African countries

Dr. Papp Nóra

8 Ethnopharmacological values of the African countries

Dr. Papp Nóra

9 Ethnopharmacology of the Mediterranean region (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

10 Ethnopharmacology of the Mediterranean region (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

11 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

12 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

13 Transylvanian ethnobotanical values.

Dr. Papp Nóra

14 Transylvanian ethnobotanical values.

Dr. Papp Nóra

15 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal

plants.

Dr. Papp Nóra

16 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal

plants.

Dr. Papp Nóra

17 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

18 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

19 Written test I.

Dr. Papp Nóra

20 Written test I.

Dr. Papp Nóra

21 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the

knowledge and view of the previous lectures.

Dr. Papp Nóra

22 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the

knowledge and view of the previous lectures.

Dr. Papp Nóra

23 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

24 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

25 Documentation of ethnobotanical data - case studies

Dr. Papp Nóra

26 Documentation of ethnobotanical data - case studies

Dr. Papp Nóra

27 Written test II.

Dr. Papp Nóra

28 Written test II.

Dr. Papp Nóra

Practices

Seminars


According to the topics of the course.

Participants



182

OPE-FAO-T APPLIED HEALTH ECONOMICS

Course director: DR. ANTAL TAMÁS ZEMPLÉNYI, assistant professor

Department of Pharmaceutics and University Pharmacy [email protected]



Course headcount limitations (min.-max.): 1 – 25 Prerequisites: OPG-GI1-T completed

Topic

Health economics applies economic thinking to the analysis of health and health care. This course provides students with an

understanding of the health economics principles and tools to analyse and address the challenges of limited resources faced by the health

sector.

By attending this course, students will

- earn about the key principles and methods of health economic evaluations and models

- know how to interpret the results of health economic evaluations

- gain insight into the perspective of decision makers

- better understand the crucial policy debates relating to health care.

The module is primarily aimed at medical, pharmacy and economic students who would like to improve their understanding of health

economics and research methods and at other students who are interested in the field.



Mid-term exams

Retake opportunity is possible following personal discussion.


Retake opportunity is possible following personal discussion.

Reading material



All presentations can be downloaded from Neptun Meet Street.

- Notes


Lectures

1 Introduction to health economics, making decisions in healthcare 1.

Kovács Sándor

2 Introduction to health economics, making decisions in healthcare 2.

Kovács Sándor

3 Economic evaluation in healthcare (CEA, CUA, CBA), threshold 1.

Dr. Zemplényi Antal Tamás

4 Economic evaluation in healthcare (CEA, CUA, CBA), threshold 2.


5 Life tables and extrapolation 1.

Kovács Sándor

6 Life tables and extrapolation 2.

Kovács Sándor

7 Measuring and valuing health outcomes (QALY) and costs in healthcare 1.


8 Measuring and valuing health outcomes (QALY) and costs in healthcare 2.


9 Health technology assessment - case studies 1.


10 Health technology assessment - case studies 2.

Kovács Sándor

11 Introduction to modelling 1.




183

12 Introduction to modelling 2.


13 Decision analytic modelling: decision trees (practical exercise) 1.


14 Decision analytic modelling: decision trees (practical exercise) 2.


15 Decision analytic modelling: Markov models (practical exercise) 1.


16 Decision analytic modelling: Markov models (practical exercise) 2.


17 Sensitivity analysis 1.

Kovács Sándor

18 Sensitivity analysis 2.

Kovács Sándor

19 Summary; presenting and interpreting cost-effectiveness analysis 1.


20 Summary; presenting and interpreting cost-effectiveness analysis 2.


21 Market access of new pharmaceuticals - case study 1.


22 Market access of new pharmaceuticals - case study 2.


23 Consultation 1.


24 Consultation 2.

Kovács Sándor

Practices

Seminars


Based on the topics of the lectures.

Participants



184

OPE-TG3-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 3





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG2-T completed

Topic



Research Society.





Mid-term exams

TG3


the semester.

- Introduction of original article published in national and/or international journals (student is co-author) at the end of 13th week of the

semester.

- Participation on Students’ Research Conference.

- Among the three conditions, one of them should be made at least.



Reading material



- Notes



Lectures

Practices

Seminars


Not applicable.

Participants




185







Topic











Mid-term exams




Reading material



..

- Notes


Lectures

Practices

Seminars



Participants







186

OPF-DTS-T THE ROLE OF DRUG TRANSPORTERS

Course director: DR. LUCA JÁROMI, assistant professor




Course headcount limitations (min.-max.): 1 – 15 Prerequisites: OPG-R1E-T completed

Topic

Understanding the clinical importance, role and molecular procedures of interindividual variability in drug response is a critical area of

drug development and clinical pharmacotherapy.The genetic polymorphisms in drug-metabolizing enzymes, receptors, transporters and

other drug targets may have a crucial role in the background of this phenomenon, that can lead to the interindividual differences in

molecular ways, efficacy, as well as toxicity as a response to numerous clinical treatment. Cancer is the leading cause of mortality and

morbidity worldwide. The greatest obstacle of the successful treatment is the development of multidrug resistance (MDR) against

chemotherapy. During the past two decades, the act of carrier-mediated transport in defining the pharamcokinetics of drugs has become

progressively evident with the discovery of genetic polymorphisms that influence expression, localization, and/or function of a given

drug transporter. The aim of the course is to present the drug transporters and their genetic and pharmacogenetic background, to explain

their role in drug metabolism, especially focusing on different drug transporter families and on interactions of protein - drug - transporters.



Mid-term exams

Félév végén vizsga, vizsgaidőszakban pótvizsga lehetőségek


Nincs, mert csak előadásokból áll a kurzus.

Reading material



PPT-bemutatók az előadások során.

- Notes


1.) Yuichi Sugiyama - Bente Steffansen: Transporters in Drug Development Discovery, Optimization,

Clinical Study and Regulation, ISSN 2210-7371 ISSN 2210-738X (electronic), ISBN 978-1-4614-8228-4 ISBN 978-1-4614-8229-1

(eBook), DOI 10.1007/978-1-4614-8229-1, Springer New York Heidelberg Dordrecht London

Library of Congress Control Number: 2013947789

2.) Toshihisa Ishikawa, Richard B. Kim: Pharmacogenomics of Human Drug Transporters, ISBN 978-0-470-92794-6

3.) Russ. B. Altman, David Flockhart, David B. Goldstein: Pharmacogenetics and Pharmacogenomics, ISBN 978-0-521-88537-9

Lectures

1 Introduction to world of drug transporters

Dr. Járomi Luca

2 General characteristics of drug transporters

Dr. Járomi Luca

3 Terms definition of drug transporters

Dr. Járomi Luca

4 Genetic role of drug transporters

Dr. Járomi Luca

5 Pharmacogenetic characteristics of drug transporters

Dr. Járomi Luca

6 Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)

Dr. Járomi Luca

7 Explanation of absorption, distribution, metabolism, and excretion (ADME)

Dr. Járomi Luca

8 Membrane transporters in ADME I.

Dr. Járomi Luca

9 Membrane transporters in ADME II.



187

Dr. Járomi Luca

10 ADME pharmacogenomics in drug development I.

Dr. Járomi Luca

11 ADME pharmacogenomics in drug development II.

Dr. Járomi Luca

12 The role of transporters in drug development: regulatory science perspectives from the FDA

Dr. Járomi Luca

13 Industrial evaluation of drug transporters in ADME

Dr. Járomi Luca

14 The pharmacogenomics of membrane transporters I.

Dr. Járomi Luca

15 The pharmacogenomics of membrane transporters II.

Dr. Járomi Luca

16 Nucleoside transporters family

Dr. Járomi Luca

17 General characteristics of ABC-transporter family

Dr. Járomi Luca

18 Most relevant ones: ABC-transporters

Dr. Járomi Luca

19 P-glycoprotein (MDR1/ABCB1)

Dr. Járomi Luca

20 ABCG2

Dr. Járomi Luca

21 Cancer: exsorptive transporters (ABC) expressed on transformed cells

Dr. Járomi Luca

22 Proton-coupled nutrient transporters affect ADME properties

Dr. Járomi Luca

23 In vitro characterization of interactions with drug transporting proteins

Dr. Járomi Luca

24 In vivo characterization of interactions on transporters

Dr. Járomi Luca

25 Indication specific transporter studies

Dr. Járomi Luca

26 Future perspectives

Dr. Járomi Luca

27 Conclusions and outlook, summary

Dr. Járomi Luca

28 Exam

Dr. Járomi Luca

Practices

Seminars


Introduction to world of drug transporters

General characteristics of drug transporters

Terms definition of drug transporters

Genetic role of drug transporters

Pharmacogenetic characteristics of drug transporters

Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)

Explanation of absorption, distribution, metabolism, and excretion (ADME)

Membrane transporters in ADME I.

Membrane transporters in ADME II.

ADME pharmacogenomics in drug development I.

ADME pharmacogenomics in drug development II.

The role of transporters in drug development: regulatory science perspectives from the FDA

Industrial evaluation of drug transporters in ADME

The pharmacogenomics of membrane transporters I.

The pharmacogenomics of membrane transporters II.



188

Nucleoside transporters family

General characteristics of ABC-transporter family

Most relevant ones: ABC-transporters

P-glycoprotein (MDR1/ABCB1)

ABCG2

Cancer: exsorptive transporters (ABC) expressed on transformed cells

Proton-coupled nutrient transporters affect ADME properties

In vitro characterization of interactions with drug transporting proteins

In vivo characterization of interactions on transporters

Indication specific transporter studies

Future perspectives

Participants



189

OPF-NSG-T PLANT PRODUCTS IN THE PHARMACEUTICAL PRACTICE






Prerequisites: OPO-G1E-T completed + OPO-G2E-T completed + OPG-O1E-T completed

Topic

Students will be familiar with the results of the latest studies on medicinal plants used in the prevention and treatment of diseases, and

the availability of authorized preparations and their use in modern medicine and health care, with their pharmacobotanical and

pharmacognosic knowledge. They should be able to make herbal preparations based on their knowledge.

Task: To present the active ingredient, medicinal use of medicinal herbs and preparations used in healing, to present the latest results of

phytotherapy research. Preparing tea blends and externally usable preparations in the practice sessions.

Requirement: Students should be able to apply their acquired knowledge to the highest possible level in their profession.



Mid-term exams

During the semester, writing of one test at an acceptable level (min. 60%) is mandatory. In case of failed result, one possibility to repeat

is possible. Taking one student lecture is mandatory.


No replacement is possible.

Reading material



- Notes


1. Aronson, JK.: Meyler’s Side Effects of Herbal Medicines, Elsevier, Oxford 2009

2. ESCOP Monographs, 2nd edition, Thieme, United Kingdom 2003

Lectures

1 Introduction. Plants on the market and their role in today’s medicine and pharmacy.

Dr. Horváth Györgyi

2 Availability of medicinal plant products on the Internet: dangers, challenges.


3 Herbs and products acting on the central nervous system.


4 Herbs and products acting on the central nervous system.


5 Herbs and products acting on heart and vascular system.


6 Herbs and products acting on heart and vascular system.


7 Herbs and products acting on respiratory tract.


8 Herbs and products acting on respiratory system.


9 Herbs and products acting on gastrointestinal tract.


10 Herbs and products acting on gastrointestinal tract.


11 Herbs and products acting on urinary tract.




190

12 Herbs and products acting on urinary tract.


13 Herbal remedies for gynecological complaints.


14 Adaptogens.


15 Herbal remedies for dermatological diseases.


16 Herbal remedies for dermatological diseases.


17 Herbs and remedies for treating pain.


18 Herbs and products for treating pain.


19 Enhancing the body’s resistance (plant immunomodulators).


20 Students’s lecture. Written test.


Practices

1 Location of herbal remedies in today’s pharmaceuticals I: Preparation of herbal product.


2 Location of herbal remedies in today’s pharmaceuticals I: Preparation of herbal product.


3 Location of herbal remedies in today’s pharmaceuticals II: Evaluation of herbal product.


4 Location of herbal remedies in today’s pharmaceuticals II: Evaluation of herbal product.


5 Praparation of herbal tea.


6 Macroscopic and organoleptic examination of herbal tea preparation.


7 Preparation of product containing essential oils.


8 Checking the quality of herbal substances by chromatography: TLC.


Seminars


The topics of the written test is the same with the lectures.

Participants

Dr. Horváth Györgyi (GDLTCH)



191

OPF-TS2-T CALCULATIONS IN PHARMACEUTICAL TECHNOLOGY 2





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C2E-T parallel + OPG-C1E-T completed

Topic

Aim of the course is to deepen the knowledge of calculations needed for Pharmaceutical Technology 2 practice (dose checking,

prescription reading and understanding) by solving and practicing several examples together with the course leader.



Mid-term exams




Students must fulfil requirements determined by the Code of Studies and Examinations. Student has to make up the missed lectures and

do work reports.

Reading material



Seminar notes.

- Notes


European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London


Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

Practices

Seminars

1 Introduction to calculations of disperse systems

Dr. Kása Péter

2 Calculations related to HLB value

Dr. Kása Péter

3 Dose checking in emulsions

Dr. Kása Péter

4 Dose checking in suspensions

Dr. Kása Péter

5 Calculations related to semi-solid dosage forms

Dr. Kása Péter

6 Introduction to calculations related to suppositories (calibration value and displacement factor)

Dr. Kása Péter

7 Calculations of divided form of prescribing suppositories

Dr. Kása Péter

8 Calculations of dispensed form of prescribing suppositories

Dr. Kása Péter

9 Dose checking of suppositories 1.

Dr. Kása Péter



192

10 Dose checking of suppositories 2.

Dr. Kása Péter

11 Dose checking of divided and undivided powders

Dr. Kása Péter

12 Test

Dr. Pál Szilárd



Participants




193

OPE-STK-T BASICS OF STEREOCHEMISTRY






Prerequisites: OPA-S2E-T completed + OPG-R1E-T completed + OPO-GE2-T completed

Topic

In the frame of this topic we will provide an overview about fundamentals of stereochemical definitions and processes. The students will

receive the most important knowledge about stereochemistry, with what they can understand the different binding types of drugs to their

place of biological action.



Mid-term exams

Students will have to write a written test at the end of the semester.


In case of absences the students must follow up with self-education!

Reading material




- Notes



K.-H. Hellwich, C. D. Siebert: Stereochemistry workbook, 191 problems and solutions, Springer, 2006.

Lectures

1 Introduction, confoguration, conformation definitions.

Dr. Huber Imre

2 Chirality, asymmetry.

Dr. Huber Imre

3 Asymmetric syntheses

Dr. Huber Imre

4 Fischer projection, CIP system.

Dr. Huber Imre

5 Diastereomers, enantiomers.

Dr. Huber Imre

6 Epimers, eutomers, distomers.

Dr. Huber Imre

7 Homochirality, inversion, meso-isomers.

Dr. Huber Imre

8 Newman projection.

Dr. Huber Imre

9 Optical purity.

Dr. Huber Imre

10 Prochirality, prostereoisomerism.

Dr. Huber Imre

11 Racemate, racemisation.

Dr. Huber Imre

12 Retention in stereochemistry.

Dr. Huber Imre



194

13 Stereoselectivity, stereospecificity.

Dr. Huber Imre

14 Summary, written test.

Dr. Huber Imre

Practices

Seminars


These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the

corresponding answers, parallely.

Participants



195

OPE-GFK-T PHYSICO-CHEMICAL BASES OF DRUG ACTION






Topic

The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets

for better understanding the drug action.



Mid-term exams

Written test.


None.

Reading material



Zsuzsanna Rozmer, Pál Perjési: The physico-chemeical bases of drug actions. PTE, 2015.

- Notes


Lectures

1 Molecular bases of biological actions. Structural characteristics of drug targets.


2 Molecular bases of biological actions. Structural characteristics of drug targets.


3 Receptors as drug targets.


4 Receptors as drug targets.


5 Enzymes as drug targets.


6 Enzymes as drug targets.


7 Transporters and ion channels as drug targets.


8 Transporters and ion channels as drug targets.


9 Nucleic acids as drug targets.


10 Nucleic acids as drug targets.


11 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.


12 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.


13 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.


14 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.


15 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.




196

16 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.


17 Physicochemical characteristics of drugs. Solubility.


18 Physicochemical characteristics of drugs. Solubility.


19 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.


20 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.


21 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.


22 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.


23 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.


24 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.


25 In silico ADME modelling. In vitro and in vivo tests.


26 In silico ADME modelling. In vitro and in vivo tests.


27 Physicochemical characteristics of drugs. Metabolic stability.


28 Physicochemical characteristics of drugs. Metabolic stability.


Practices

Seminars


Topics of the written tests are set by the course director.

Participants

Dr. Rozmer Zsuzsanna (IIDYH7)



197

OPE-TG4-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 4





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPE-TG3-T completed

Topic



Research Society.





Mid-term exams

TG4


the semester.

- Introduction of an article published in a national and/or international journal (student is co-author). It must be sent to the course

supervisor at the end of 13th week of the semester.

- Oral presentation at the Students’ Research Conference.

- Dean’s thesis

- Among the four conditions, one of them should be made at least.



Reading material



- Notes



Lectures

Practices

Seminars


Not applicable.

Participants




198

OPE-VFM-T BUSINESS DEVELOPMENT AND MANAGEMENT

Course director: DR. RITA BOGNÁR, research associate professor





Topic

The main objective of the course is to develop the business orientation skills of the students, while deepening their knowledge in business

models, business plans, innovative business strategies, time-, product-, process- and human resource management. Participants will have

the capability how to develop healthcare businesses in international environment and how to plan better their time.



Mid-term exams

TVSZ szerint


TVSZ szerint

Reading material



Neptun

- Notes


1. Baum Neil, Thomas Raju : The Basics of Business of Medicine, 2015

2. Helen Ewing: Healthcare Finance: An Introduction to Accounting and Financial Management, 5th edition, 2013

Lectures

1 Global healthcare

Dr. Bognár Rita

2 Different healthcare systems

Dr. Bognár Rita

3 Regional healthcare

Dr. Bognár Rita

4 Different types of business organisations

Dr. Bognár Rita

5 Innovation, Innovative businesses

Dr. Bognár Rita

6 Business Model Generation

Dr. Bognár Rita

7 Business plan

Dr. Bognár Rita

8 Business plan development

Dr. Bognár Rita

9 Intercultural business communication

Dr. Bognár Rita

10 Basics of Marketing in healthcare business

Dr. Bognár Rita

11 Production

Dr. Bognár Rita

12 Product and process management

Dr. Bognár Rita

13 Quality management

Dr. Bognár Rita

14 Time planning, Time management



199

Dr. Bognár Rita

15 Human resource management

Dr. Bognár Rita

16 Team building, Team work

Dr. Bognár Rita

17 Strategic management

Dr. Bognár Rita

18 Risk management

Dr. Bognár Rita

19 Healthcare finance

Dr. Bognár Rita

20 Introduction to accounting and financial management

Dr. Bognár Rita

21 Sustainable healthcare

Dr. Bognár Rita

22 Presenation methods and techniques

Dr. Bognár Rita

23 Administration, Documentation, Reports

Dr. Bognár Rita

24 Summary

Dr. Bognár Rita

Practices

Seminars


Neptun

Participants

Dr. Bognár Rita (HEILL4)



200

OPE-ASZ-T THE ANTIMICROBIAL DRUGS AND THEIR CLINICAL USE

Course director: DR. BÉLA KOCSIS, associate professor

Department of Medical Microbiology and Immunology [email protected]





Topic

The aim of these lectures is to give a reliable and detailed knowledge about the antimicrobial drugs and their clinical use; to give ideas

how to choose the proper drug for the prophylaxis and therapy of infectious diseases



Mid-term exams

In the first 2 weeks of the exam period we give three times possibilities to write tests


None

Reading material


Jawetz et al.: Medical Microbiology


- Notes


Lectures

1 Introduction, historical data, basic definitions

Dr. Kocsis Béla

2 Characterisation of antimicrobial drugs, chemical structure, their targets

Dr. Kocsis Béla

3 Characterisation of antimicrobial drugs, sensitivity and resistance

Dr. Kocsis Béla

4 Pharmacokinetics and pharmacodynamics of anti-infective drugs

Dr. Kocsis Béla

5 The antibiotic prophylaxis.

Dr. Kocsis Béla

6 The empiric antimicrobial therapy

Dr. Kocsis Béla

7 The antimicrobial therapy based on microbiologic result

Dr. Kocsis Béla

8 The choice of best antimicrobial drug

Dr. Kocsis Béla

9 The reasons of an unsuccessful antimicrobial therapy

Dr. Kocsis Béla

10 The antimicrobial drugs in details. The inhibitors of the cell wall biosynthesis Beta-lactams Penicillins

Dr. Kocsis Béla

11 Cephalosporins, carbapenems, monobactams, glicopeptides

Dr. Kocsis Béla

12 The inhibitors of the protein biosynthesis Aminoglicosides

Dr. Kocsis Béla

13 Tetracyclines Chloramphenicol Macrolides

Dr. Kocsis Béla

14 The inhibitors of the nucleic acid biosynthesis Rifampins Sulfonamides

Dr. Kocsis Béla



201

15 Kinolons Fluorokinolons

Dr. Kocsis Béla

16 The antimycotic drugs

Dr. Kocsis Béla

17 The antiviral drugs HIV - AIDS

Dr. Kocsis Béla

18 The antiparasitic therapy. The chemoprophylaxis of malaria

Dr. Kocsis Béla

19 The antimicrobial therapy of respiratory and urinary tract infections

Dr. Kocsis Béla

20 Cardiovascular and wound infections, sepsis

Dr. Kocsis Béla

21 Central nervous system, abdominal and enteric infections

Dr. Kocsis Béla

22 Antimicrobial therapy of patients under immunosuppression, pregnancy....

Dr. Kocsis Béla

23 The pharmacological aspects of antimicrobial therapy

Dr. Kocsis Béla

24 The future of antimicrobial therapy

Dr. Kocsis Béla

Practices

Seminars


None

Participants



202







Topic











Mid-term exams




Reading material



..

- Notes


Lectures

Practices

Seminars



Participants







203

OPE-KPR-T CHEMOPREVENTION






Topic

Chemoprevention is the administration of natural or (semi)synthetic agents to prevent, inhibit, or delay the progression of chronic

diseases. The focus is on cancer chemoprevention.

The way from a potent agent to a chemopreventive strategy will also be discussed.

Involving (chemo)preventive interventions in every-day practice could spare valuable life years.



Examination: test

Mid-term exams

Examination: test


based on individual consideration

Reading material




- Notes


Lectures

1 Introduction - Chemoprevention as a preventive strategy

Dr. Szabó István

2 Introduction - Chemoprevention as a preventive strategy

Dr. Szabó István

3 Finding evidence

Dr. Szabó István

4 Finding evidence

Dr. Szabó István

5 Interventing chronic diseases

Dr. Szabó István

6 Interventing chronic diseases

Dr. Szabó István

7 Chemopreventive strategies - antioxidants

Dr. Szabó István

8 Actualities of antioxidants

Dr. Szabó István

9 Natural chemopreventive agents

Dr. Szabó István

10 Natural chemopreventive agents

Dr. Szabó István

11 Chemopreventive dietary factors

Dr. Szabó István

12 Chemopreventive dietary factors

Dr. Szabó István



204

Practices

Seminars


Neptun

Participants



205

OPF-FEA-T BASICS OF INFECTIOUS DISEASE EPIDEMIOLOGY





Course headcount limitations (min.-max.): 5 – 15 Prerequisites: OPO-I2E-T completed


Topic

However the morbidity and mortality caused by infectious diseases has significantly declined in the developed countries in the last

century due to the effective prevention methods, their complete elimination is not possible, infectious diseases are still part of our

everyday life. The spread of infectious diseases could be controlled by timely identification, proper investigation and by targeted

interventions. Aim of the course is to present the special characteristics of infectious diseases, and of infectious disease epidemiology;

basics and functioning of surveillance systems, the basics and steps of an outbreak investigation, and epidemiological methods used

during the investigation.


The participation in the lectures, seminars, practises is obligatory (a catalogue should be signed), a maximum of 2x45 min absence is

acceptable, above the signature will be rejected.

Mid-term exams


None

Reading material



- Notes


Heymann (ed.): Control of Communicable Diseases Manual

Mikanatha, Lynfield, Van Beneden, de Valk (eds.): Infectious Disease Surveillance

Lectures

1 Special characteristics of infectious diseases

Dr. Prantner Ida

2 Basics of infectious disease epidemiology I

Dr. Prantner Ida

3 Basics of infectious disease epidemiology II

Dr. Prantner Ida

4 Methods used in infectious disease epidemiology

Dr. Prantner Ida

5 Basic principles of surveillance

Dr. Prantner Ida

6 Infectious disease surveillance

Dr. Prantner Ida

7 Basics and steps of outbreak investigation I

Dr. Prantner Ida

8 Basics and steps of outbreak investigation II

Dr. Prantner Ida

9 Investigation of a food-borne outbreak

Dr. Prantner Ida

Practices

1 Use of epidemiological knowledge in practice I (definitions, surveillance data interpretation, analysis)

Dr. Prantner Ida

2 Use of epidemiological knowledge in practice II (Data collection, analysis, graphical interpretations)

Dr. Prantner Ida

3 Use of epidemiological knowledge in practice III (analytic studies)

Dr. Prantner Ida



206

Seminars


Participants

Dr. Prantner Ida (WO4A8D)



207

OPF-KIA-T ESSENTIAL OILS AND CLINICAL AROMATHERAPY





Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPG-O1E-T completed + OPG-O2E-T completed

Topic

Essential oils (EOs) are very interesting natural products and among other qualities they possess various biological properties. The term

biological comprises to all activities that these mixtures of volatile compounds (mainly mono- and sesquiterpenoids, phenylpropanoids,

etc.) exert on humans. EOs are used for their therapeutic action, for flavouring, in perfumery, or as starting materials for the synthesis of

other compounds. For therapeutic purposes they are administered as inhalations (e.g. eucalyptus oil), orally (e.g. peppermint oil) and

transdermally (e.g. rosmary oil). Oils with a high phenol content, for instance thyme and clove, have antiseptic properties, whereas others

are used as carrminatives. Oils showing antispasmodic activity, and much used in popular medicine, are those of melissa, peppermint,

chamomile, fennel, caraway and orange. Furthermore, in traditional medicine, EOs are also well-known for their analeptic, antimicrobial,

antinociceptive, antiphlogistic, antioxidative and sedative activities. All terpenoids easily enter the human body by oral absorption,

penetration through the skin, or inhalation very often leading to measurable blood concentrations. The aim of this course is to introduce

the most important medicinal plants containing essential oils and their medicinal role in the therapy and the clinical aromatherapy. We

would like to highlight their appropriate use, their profiles, but to call students’ attention to the cautions and contraindications of EOs, as

well.



Mid-term exams

Two written exams during the semester, acceptance of them from 60%.



Reading material



PowerPoint presentations prepared by lecturers.

- Notes


1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London, New York, 2000

2. Tisserand R., Balacs T.: Essential Oil Safety: A Guide for Health Care Professionals, Churchill Livingstone, 1995

3. Tisserand R., Young R: Essential Oil Safety: A Guide for Health Care Professionals, Second edition, Churchill Livingstone, 2013

Baser C.H, Buchbauer G.: Handbook of Essential Oils. Science, Technology and Application. CRC Press, Boca Raton, 2010

Lectures

1 Introduction of the course requirements. Definition of aromatherapy and clinical aromatherapy.


2 Advantages and disadvantages of the application of essential oils.


3 History of the use of essential oils.


4 Biological activities of essential oils.


5 Sources of essential oils.


6 Chemistry of essential oils. Chemical composition of essential oils.


7 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas

chromatographic analysis of essential oils.




208

8 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas

chromatographic analysis of essential oils.


9 Drugs containing essential oils in the European Pharmacopoeia and in the ESCOP Monograph.


10 Quality of essential oils according to the official Pharmacopoeias.


11 External application of essential oils.


12 The most important base oils.


13 Physiological effects of essential oils. Metabolism of essential oil components in animal models and humans.


14 Contraindications.


15 Written test I


16 Written test I


17 Antimicrobial activity of essential oils. In vitro methods.


18 Antimicrobial activity of essential oils. In vivo methods.


19 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,

lavender oil.


20 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,

lavender oil.


21 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.


22 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.


23 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,

carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.


24 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,

carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.


25 Safety guidelines of essential oils.


26 Safety guidelines of essential oils.


27 Written test II


28 Written test II


Practices

Seminars


There is no list. The questions of the written test is similar to the lecture topics.

Participants



209

OPE-FMA-T DATA ANALYSIS 1






Topic

The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers mainly two

fields of that: read and interpret scientific papers and prepare an own study plan. Shortly to say: How to prepare for your own study

project.

Block One: The medical papers are likely the most important source to improve your present knowledge as a student and as an

MD. Most of these ‘original papers’ are based on carefully planned data collection and evaluation applying a wide array of statistical

methods. It is essential to be familiar with this methodology so to understand these papers. But you may learn these steps and methods

from the papers since all are based on the rules of designing scientific research projects. From a paper you may extract the principles as

well as you can follow immediately the realization. It is an excellent way to learn the methodology. You may even learn from the errors.

Block Two: Apply all these for your own research: make a study plan. It should include your study goal the extent and way of

your data collection the preliminary data processing the way of data analysis and the way of conclusion making.

Based on this outline you will prepare your own study design on your own student”s research work or on your thesis job. If you have no

such project at the moment you may construct an own “sample study plan” that can be a working model for your future thesis

work. You will have all help to find your own project and complete the plan in the practice if you need. All of your personal design

elements will be discussed and improved by a class discussion.

The practical realization of your study will be supported by the Data analysis 2 course.


Maximum 1 lesson absence.

Mid-term exams

Prepare and submit your own study plan step-by-step and present sortly weekly to the group - based on your active participation.


One extra class

Reading material


1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).


Other supporting materials supplied by the tutor of the classes.

- Notes


Any statistical books on study design and data analysis.

Lectures

1 Introduction. Find a paper to process. Find your own study.

Dr. Pótó László

2 The goal of your study - based on a demo paper

Dr. Pótó László

3 The main- and ‘sub-’hypotheses of the study.

Dr. Pótó László

4 Finding your sample frame - based on your hypotheses.

Dr. Pótó László

5 The research design and the methods of the data collection. How many data should be collected?

Dr. Pótó László

6 Creating the plan of the data analysis. The complete study plan.

Dr. Pótó László



210

Practices

1 Introduction. Overview of some sample papers.

Dr. Pótó László

2 The goal of your study - processing a few papers brought and presented by students.

Dr. Pótó László

3 Setting the study hypotheses. Further analysis of the papers.

Dr. Pótó László

4 Which data should you collect and how to do that.

Dr. Pótó László

5 Finalize the plan of your data collection. Make a plan of the data processing.

Dr. Pótó László

6 Create, present and discuss of your study plan.

Dr. Pótó László

Seminars


Preparation of the study plan

Participants




211

OPE-FM2-T DATA ANALYSIS 2





Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPE-FMA-T parallel

Topic

The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers two fields

of that job: the practice of data collection and prepare data for the analysis as well as the performing the analysis based on the preliminary

analysis plan. Shortly to say: How to perform the data collection and analysis of your own study project. (This course can be the

continuation of the ‘Data analysis 1” course however someone can complete these two courses on a reversed order as well. The

main reason of this flexibility is, that many students are asking for help when they have already had their data at hands (at least partially),

and this course is processing the steps from this point of the job. Even though, it is beneficial for the students doing this course first to

complete the Data analysis 1 course later. They can do it next year for example - so to understand the preliminary steps of a research

work: How to make a research plan?)

This course is also based on the medical papers. Students may pick the appropriate data collection methods and recognize the critical

points of this process based on the most fundamental papers of their own research field. They can learn from the most rewarded experts

on this way. From a paper you may extract the principles as well as you can follow immediately the realization. It is an excellent way to

learn the methodology. You may even learn from the errors.

The same way is followed for the data analysis and making conclusions. Every student will do his/her own data analysis based on their

own plan.

Students will have all help to the practical evaluation of their own data and making the right conclusion. The steps and results will be

discussed and improved by a class discussion.


Maximum 1 lesson absence.

Mid-term exams

Evaluate your data step by step and present it to the group weekly.


One extra class

Reading material


1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).


Supporting materials (papers, posters, research reports, ...) supplied by the tutor of the classes.

- Notes


Any statistical books.

Lectures

1 Introduction. Find a paper to process. Prepare or present your own data collection plan.

Dr. Pótó László

2 The realization of the data collection - examples are based on papers

Dr. Pótó László

3 The preliminary data preparations for the following statistical analysis.

Dr. Pótó László

4 Do your own statistical analysis 1-2: - select the right methods, - interpret the results.

Dr. Pótó László

5 Make your conclusion and share the results with the others.

Dr. Pótó László

6 Summary. Consolidation and evaluation of the results.

Dr. Pótó László



212

Practices

1 Find a paper to process. Work on your own data collection plan.

Dr. Pótó László

2 Present the realization of the data collection - based on selected papers

Dr. Pótó László

3 Share your experiences on your preliminary data preparations - make corrections if needed.

Dr. Pótó László

4 Present your own statistical analysis - methods and results

Dr. Pótó László

5 Make your conclusion and share the results with the others.

Dr. Pótó László

6 Overview and summarize the results of the class.

Dr. Pótó László

Seminars


Evaluate your data and submit your own results based on your active participation.

Participants




213







Topic











Mid-term exams




Reading material



..

- Notes


Lectures

Practices

Seminars



Participants







214

OPE-OPM-T ONLINE PHARMACEUTICAL MARKET AND THE DANGERS OF COUNTERFEIT MEDICINES

Course director: DR. ANDRÁS TAMÁS FITTLER, associate professor

Department of Pharmaceutics and University Pharmacy [email protected]



Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GI1-T completed

Topic

Thousands of internet pharmacies are accessible on the web, and a vast number of illegitimate vendors overwhelm the market of online

pharmaceuticals. This illegal market segment operates within an uncontrolled environment, with no restrictions on vendors, consumers

or products, in which practically anyone can purchase any type of medication – including counterfeit drugs – without a prescription,

medical supervision or appropriate diagnosis, consequently compromising patient and medication safety. International and national

authorities lack efficient tools to discover and shut down illicit pharmacy websites and stop the illicit trade of counterfeit medicines.

Accordingly, advanced computational methods are needed to detect and mitigate cybercriminal activity, and efficient inter-disciplinary

communication and public awareness campaigns to inform consumers.

The course will provide insight into the current issues of the online pharmaceutical market and the dangers of counterfeit medicines. Real

world data on legitimate and rogue online pharmacies, various stakeholders, networks, products and information content will be

introduced, along with the discussion of measures combating illegal peddling of pharmaceuticals. Novel information technology and

data-science methods on the evaluation of this enormous online market will be discussed.

Students can access resources for their individual and group assignment, further the slides of the lectures and further reading material on

a designated web based interface (e.g. MS Teams and/or Neptun Meet Street).


Acceptance of term/semester:

- Regular attendance of classes, student should be able to work project-oriented and independently.

- Assignments and project work given in class should be carried out during term-time

- Presentation of project work

Mid-term exams

There are no midterm tests, however participants will present their individual and group assignments and prepare for their project work.


Oportunity is possible following personal discussion.

Reading material



List of study aids to acquire curriculum and all presentations can be downloaded from MS Teams and/or Neptun MeetStreet.

- Notes


-Fittler András, Vida Róbert György, Káplár Mátyás, Botz Lajos: Consumers Turning to the Internet Pharmacy Market, JOURNAL

OF MEDICAL INTERNET RESEARCH 20: (8) e11115

- Vida Róbert György, Merczel Sára, Jáhn Eszter, Fittler András: Developing a framework regarding a complex risk based

methodology in the evaluation of hazards associated with medicinal products sourced via the internet, SAUDI PHARMACEUTICAL

JOURNAL 28: (12) pp. 1733-1742.

Lectures

1 Development and current issues of the online pharmacy market

Dr. Fittler András Tamás

2 Frequency and attitudes of consumers/patients purchasing medications online.


3 Current practice and legal framework of online drug distribution in Europe, international comparison


4 Facilitators of the online pharmacy market: self-medication, telemedicine, drug shortages, infodemic, etc.




215

5 The role of the Falsified Medicines Directive in preventing falsified medicines entering the legal supply chain and reaching

patients


6 Evaluation of international pharmacy networks on the internet, applications of data science methods (lecturer: Prof. Dr Péter

Iványi, Faculty of Engineering and Information Technology)


7 Application of machine learning in identification of oral medicines to combat against falsified medicines and increase medication

safety

Dr. Feldmann Ádám

Practices

1 Nomenclature and categorization of online pharmacies. Identifying stakeholders of the market. (individual assignment)


2 Evaluation of the potential benefits and risks from various aspects. SWOT analysis from patient/consumer’s, authority and online

vendor’ perspective (group work)


3 Importance of the closed drug supply chain and identification of the global threats of integrity (group work)


4 The problem and prevalence of counterfeiting and falsifying of medicinal products – Introduction of project work on the

international significance of counterfeit drugs and potential countermeasures

Dr. Vida Róbert György

5 Technologies against counterfeit medicine. Introduction and assessment of national and international verification systems of

online vendors (group work)


6 Assessment of search engine result pages, online vendor characteristics and product information. Application of a complex risk

assessment methodology for project work.


7 Presentation and discussion of project works: e.g. Evaluation of hazards associated with medicinal products sourced via the

internet, Fighting the global trade of counterfeit medicines, etc.


Seminars


End-of-the-term test is organized in Neptun Unipoll at the regular time of lectures. The test will be on the whole semester’s curriculum.

The end-of-the term test grade may be accepted as an examination grade, if passed. Assessment of the student performance is carried

out according to a five-grade scale:100-86,1% -excellent (5); 86-77,1% -good (4); 77-68,1% -satisfactory (3); 68-60,1% -pass (2);

and below 60,0% -fail (1) respectively.

Participants

Dr. Fittler András Tamás (IYR5HQ), Dr. Vida Róbert György (BN08GS)



216

OPE-SHK-T DESIGN AND INDUSTRIAL MANUFACTURE OF MEDICINES





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-BFR-T completed + OPG-C2E-T completed

Topic

During the course, the process of the design of modified drug delivery systems is acquired by the students based on the theory and

practice of biopharmaceutical including examinations of dosage forms. The course consists of theoretical lectures and seminars.



Mid-term exams

Students have to write an end-semester assessment from the lectures at acceptance level of 60%.


Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and

work reports.

Reading material



- Notes


Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press


Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare

Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone

Lectures

1 Floating drug delivery, Targeted Drug Delivery Systems

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

5 Introduction of modified drug delivery

Dr. Kása Péter


Dr. Kása Péter


Dr. Kása Péter


Dr. Kása Péter

9 Targeted Drug Delivery Systems

Dr. Secenji Aleksandar


Dr. Secenji Aleksandar


Dr. Pál Szilárd


Dr. Pál Szilárd



217

13 Pulsative Drug Delivery Systems

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

17 Dissolution, lecture and practice

Dr. Lendvai Botond István


Dr. Lendvai Botond István


Dr. Pál Szilárd


Dr. Pál Szilárd

21 From molecule to the preparition

Dr. Kása Péter


Dr. Kása Péter


Dr. Pál Szilárd


Dr. Pál Szilárd

25 3D printing in pharmaceutical technology

Kopcsányi Márton

26 3D printing in pharmaceutical technology

Kopcsányi Márton

27 Assessment

Dr. Pál Szilárd

28 Assessment

Dr. Pál Szilárd

Practices

Seminars



Participants

Dr. Kása Péter (ISWPRM), Dr. Lendvai Botond István (U0UI6H), Dr. Pál Szilárd (FYF5E9), Dr. Secenji Aleksandar (DI7BVF),

Kopcsányi Márton (D3S7AX)



218

OPF-GTH-T GENE THERAPY

Course director: DR. GÉZA SÁFRÁNY, visiting professor

Institute of Laboratory Medicine [email protected]




Topic

We wish to give a short overview about the present state of gene therapy, the current ongoing clinical trials and the potential side effects

of gene therapy and about the ethical considerations. The various viral and non-viral gene delivery protocols suitable for high efficiency

gene delivery both under in vitro and in vivo conditions will be discussed in details. Gene therapy protocols applied in the treatment of

malignant diseases will be presented together with the results of ongoing clinical trials. We will talk about the results and the potentials

of the treatments of inherited genetic disorders. One of the most promising field of the current clinical trials is the treatment of ischemic

diseases, the results will be presented. The potential applications of stem cells during gene therapy will be described, as well. Finally, we

will discuss the side effects occurring during gene therapy and the ethical considerations will also be mentioned.



Mid-term exams

1 Test


Joining later lectures, individual consultations.

Reading material


1. Kelly K. Hunt, Stephan A. Vorburger and Stephen G. Swisher (ed.): Gene Therapy for Cancer, 2007 Humana Press Inc. 999

Riverview Drive, Suite 208 Totowa, New Jersey 07512

2. Thomas F. Kresina (ed.): Introduction to Molecular Medicine and Gene Therapy, 2001 by Wiley-Liss, Inc. ISBNs: 0-471-39188-

3 (Hardback); 0-471-22387-5 (Electronic)


1. Sáfrány G.: A génterápia génsebészeti alapjai és jelenlegi helyzete, A Genom (ed.: Hídvégi EJ), Budapest, Széphalom

Könyvműhely 2003, pp 187-204

2. Sáfrány G.: A vasculáris génterápia és a csontvelőőssejt-terápia, Atherosclerosis (ed.: Császár A.), Budapest, Synergo Kiadó,

2004 pp 336-344

- Notes


http://www.genetherapynet.com/clinicaltrialsgov.html

http://www.bioportfolio.com/cgi-bin/acatalog/Human_Gene_Therapy_Course.html

http://openlearn.open.ac.uk/course/view.php?id=2430

Lectures

1 Introduction to gene therapy, ongoing clinical trials

Dr. Sáfrány Géza

2 Gene delivery protocols, viral vectors applied in gene therapy

Dr. Sáfrány Géza

3 Targeted gene delivery and targeted gene expression

Dr. Sáfrány Géza

4 Application of dendritic cells in gene therapy

Dr. Sáfrány Géza

5 Gene directed enzyme pro-drug therapy of malignant diseases

Dr. Sáfrány Géza

6 Immune therapy of malignant diseases

Dr. Sáfrány Géza

7 Gene therapy of leukaemia

Dr. Sáfrány Géza

8 Treatment of immune-deficiencies with gene therapy

http://www.genetherapynet.com/clinicaltrialsgov.html

http://www.bioportfolio.com/cgi-bin/acatalog/Human_Gene_Therapy_Course.html

http://openlearn.open.ac.uk/course/view.php?id=2430



219

Dr. Sáfrány Géza

9 Gene therapy of ischemic diseases

Dr. Sáfrány Géza

10 Gene therapy of cystic fibrosis

Dr. Sáfrány Géza

11 Gene therapy of thalassemia

Dr. Sáfrány Géza

12 Oncolytic viruses in tumor therapy

Dr. Sáfrány Géza

Practices

Seminars


Multiple choice tests for checking the acquisition of course material is given at the end of semester. Questions include material discussed

in lectures and seminars.

Participants

Dr. Sáfrány Géza (UYX8V2)



220







Topic











Mid-term exams




Reading material



..

- Notes


Lectures

Practices

Seminars



Participants







221

OPE-DRO-T DRUG AND SUBSTANCE ABUSE

Course director: DR. ERIKA SÁNTICS-PINTÉR, professor




Course headcount limitations (min.-max.): 5 – 30 Prerequisites: OPG-D1E-T completed

Topic

The course aimed to provide general terms of drug and substance abuse and present its physiological and biochemical background. We

are going to review systematically the most important pharmacological features of the drugs of abuse, the symptoms, dangers and possible

treatments of abuse. The drugs are discussed in the following sections: opioids, anxiolytics, sedatohypnotics, inhalants, alcohol,

psychomotor stimulants (amphetamin and derivates, cocain, coffein, nicotin), psychedelics and hallucinogens (LSD, mescalin,

phencyclidin), cannabis. After the discussion of pharmacology the participants can hear about the practical problems of drug abuse. At

the end of the course the students should present 5-10 minute ppt presentations from different abuse-related topics.



Mid-term exams




Reading material



Uploaded on the Neptun

- Notes


Lectures

1 General terms of drug abuse, definition of dependence and tolerance

Sánticsné Dr. Pintér Erika

2 General terms of drug abuse, definition of dependence and tolerance


3 Opioid abuse

Dr. Horváth Ádám István

4 Abuse of anxiolytics and sedatohypnotics. Inhalants.


5 Alcohol abuse


6 Abuse of psychomotor stimulants


7 Psychedelics, hallucinogens, cannabis


8 Designer drugs


9 Practical problems of drug abuse

Dr. Szemelyácz János

10 Practical problems of drug abuse

Dr. Szemelyácz János

11 Presentations of students


12 Written exam




222

Practices

Seminars


1. General terms of drug abuse, definition of dependence and tolerance

2. Opioid abuse

3. Abuse of anxiolytics and sedatohypnotics. Inhalants.

4. Alcohol abuse

5. Abuse of psychomotor stimulants

6. Psychedelics, hallucinogens, cannabis

7. Designer drugs

Participants



223

OPE-FAJ-T PAIN AND ANALGESICS

Course director: DR. GÁBOR ISTVÁN PETHŐ, professor





Topic

The aim of the course is to give an integrative overview on the physiological, pathophysiological and pharmacological aspects of pain.

Major tasks are to (i) provide information on peripheral and central mechanisms of pain and hyperalgesia; (ii) describe the major features

of existing analgesics including opioids, non-steroidal antiinflammatory agents and adjuvant analgesics; (iii) outline novel targets for

development of analgesic drugs. The course will also help students prepare for the exams in Pharmacology 2 and 3.



Mid-term exams

After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do

not write this test have a second chance until end of Week 12 of the instruction period to improve in form of an oral conversation. Upon

failing or missing there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.


There is no way to make up for missed lectures.

Reading material


None.


The material of the lectures is available in PDF format in the Neptun.

- Notes

None.


None.

Lectures

1 Basic terms related to pain and nociceptors

Dr. Pethő Gábor István

2 Features of capsaicin-sensitive nociceptors


3 Peripheral mechanisms of hyperalgesia


4 Central mechanisms of hyperalgesia and allodynia


5 Features of neuropathic pain


6 Pharmacology of opioid analgesics


7 Pharmacology of non-steroidal antiinflammatory analgesic drugs


8 Adjuvant analgesics


9 New targets for development of analgesics I


10 New targets for development of analgesics II




224

Practices

Seminars


No exam questions are given. The essay questions of the written exam are based on the material presented.

Participants



225

OPE-MGT-T PHARMACEUTICAL TECHNOLOGY OF MODIFIED DRUG RELEASE





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C4E-T parallel

Topic

Students can get acquainted in details with modified drug delivery technologies and special industrial drug manufacture (3D printing,

manufacture of multi-layer tablets and osmotic preparations) and the importance of pharmaceutical excipients. Student will learn special

manufacturing technologies through the demonstration of dosage forms already available in the pharmaceutical therapy.



Mid-term exams

During the end semester test 60 % should be reached.


According to the Code of Studies and Examinations

Reading material



- Notes


James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, 2011

Lectures

1 Theory of modified drug release

Dr. Pál Szilárd

2 Importance of excipients, patents of excipient-compositions

Dr. Kása Péter

3 Immediate drug-release (OraSolv, DuraSolv, Zydis technology)

Dr. Pál Szilárd

4 Sustained drug-release: Multiparticulate dosage forms I. (sustained release pellets in practice)

Dr. Pál Szilárd

5 Multiparticulate dosage forms II. (MUPS technology)

Dr. Pál Szilárd

6 Matrix systems I. (hydrophilic matrices)

Dr. Pál Szilárd

7 Matrix systems II. (hydrophobic matrices)

Dr. Pál Szilárd

8 Osmotic technology (EOP, OROS, L-OROS, GITS)

Dr. Pál Szilárd

9 Geometry based drug-release (Geomatrix, Procise, Smartrix technology)

Dr. Kása Péter

10 Chronotherapeutic systems (Geoclock technology)

Dr. Pál Szilárd

11 3D printing in the field of modified drug delivery

Dr. Pál Szilárd

12 Site specific drug release (gastroretentive systems, colon-specific drug delivery)

Dr. Pál Szilárd

13 Halving of tablets, technology of halving-friendly tablets, concept of ,,ghost” tablets

Dr. Kása Péter

14 End-year test

Dr. Pál Szilárd



226

Practices

Seminars


http://gytk.pte.hu

Participants


http://gytk.pte.hu/



227

OPE-IVF-T INFECTIONS AND IMMUNITY

Course director: DR. JÚLIA BARTHÓ-SZEKERES, professor




Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPO-IMM-T completed + OPO-MI1-T completed


Topic

The importance of anti-infectious immunity is not restricted to elimination of pathogens, but is also responsible for long lasting protection,

as well as -in some cases- immunopathological disorders



Mid-term exams

Continuous


Consultation

Reading material



Lecture slides

- Notes


1. H. Chapel, M. Haeney, N. Misbah, Snowden: Clinical Immunology, Blackwell, 2008

2. S. Kartikeyan, R.N. Bharmal, R.P. Tiwari, and P.S. Bisen: HIV and AIDS: Basic Elements and Priorities, 2007

3. T. Platts-Mills and Johannes Ring: Allergy in Practice, 2003

Lectures

1 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.

Dr. Barthóné Dr. Szekeres Júlia

2 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.


3 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.


4 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.


5 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.


6 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.


7 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.


8 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.


9 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.


10 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.


11 Evasion and use of the innate and adaptive immune responses by microorganisms.


12 Evasion and use of the innate and adaptive immune responses by microorganisms.




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13 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,

sepsis, endotoxin shock, toxic shock syndrome.


14 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,

sepsis, endotoxin shock, toxic shock syndrome.


15 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.


16 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.


17 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.


18 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.


19 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.






22 Immunopathological alterations following viral infections. The involvement of antibodies.


23 Vaccination; Type of vaccines, requirements for vaccines.


24 Vaccination; rational vaccine development, mandatory vaccines.


Practices

Seminars


The same as lecture topics

Participants



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OPF-SUO-T EMERGENCY MEDICINE

Course director: DR. PÉTER LÁSZLÓ KANIZSAI, associate professor

Department of Emergency Medicine [email protected]



Course headcount limitations (min.-max.): 5 – 150 Prerequisites: OPO-KL1-T completed


Topic

It is prudent to understand the emergency concept for health care providers not involved in acute care. The purpose of the subject is to

understand the aims and principles of emergency care, to get familiar with emergency approach based on focused assessment and care,

risk stratification. It is also important to understand the essences of team approach and make patients comfortable by providing safe and

patient centered care within our given time-range, i.e. 24 hours.


Test exam.

Mid-term exams


Personal communication with the tutors.

Reading material


R. Aghababian: Essentials of Emergency Medicine, 2nd edition


- Notes


Lectures

1 History of emergency care, emergency aspects, structured communication

Dr. Kanizsai Péter László

2 Prehospital care

Dr. Bóna Ernő

3 Triage, teamwork


4 Emergency group of symptoms

Dr. Szilágyi Csilla

5 Pain syndromes

Dr. Labudek Renáta

6 From door to needle (ACS and stroke care - emergency aspects)

Dr. Merész Márton

7 Environmental emergencies

Dr. Sparas Ákos

8 Care of the severely injured


9 Paediatric emergency care

Dr. Bánfai Gábor László

10 Toxicology basics

Dr. Bóna Ernő

11 Sepsis in the emergency department


12 Interactive consultation between the Hungarian university emergency departments




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Practices

Seminars


Website of Emergency Medicine, University of Pécs.

Participants



231







Topic











Mid-term exams




Reading material



..

- Notes


Lectures

Practices

Seminars



Participants







232

OPE-GST-T SPECIAL FIELDS OF PHARMACOLOGY

Course director: DR. GÁBOR ISTVÁN PETHŐ, professor





Topic

The aim of the course is to present those fields of pharmacology that are not covered at all or only partially discussed in the compulsory

courses Pharmacology 1-2-3 because of time limits. These are the following: use of drugs during pregnancy and lactation; significance

of pharmacogenomics in therapy and drug development, pharmacology of retinoids; other drugs used in dermatology; use of meta-

analysis in evaluation of drugs, clinical significance of basic pharmacodynamic and pharmacokinetic parameters; special aspects of drugs

used by inhalation, basics of chronopharmacology; pharmacology of contrast media, drugs and chirality. The course wishes to contribute

to a better understanding of the use of drugs in the clinical practice and may help students prepare for the pharmacology exams.



Mid-term exams

After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do

not write this test have a second chance until the end of Week 12 of the instruction period to improve in form of an oral conversation.

Upon failing or missing there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.


There is no way to make up for missed lectures.

Reading material


None.


The material of the lectures is available in PDF format in the Neptun.

- Notes

None.


None.

Lectures

1 Special aspects of use of drugs during pregnancy and lactation


2 Significance of pharmacogenomics in therapy and drug development


3 Use of meta-analysis in evaluation of drugs


4 Drugs and chirality


5 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases

I


6 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases

II


7 Pharmacology of retinoids


8 Drugs (other than retinoids) used in dermatology


9 Pharmacology of contrast media


10 Basics of chronopharmacology



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Practices

Seminars


No exam questions are given. The essay questions of the written exam are based on the material presented.

Participants

STUDY PROGRAM 2021/2022 Elective and Optional Subjects

Documents

Transcript of STUDY PROGRAM 2021/2022 Elective and Optional Subjects