STUDY PROGRAM 2016/2017 Elective and Optional subjects · UP FP Pharmacy major – Elective and...

UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2016/2017

1

University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2016/2017

Elective and Optional subjects


2

ELECTIVE SUBJECTS FOR THE BASIC MODULE

1st semester

OPE-BFA Physical Basis of Biophysics ______________________________________________________________________ 5

OPE-BO1 Biophysics Seminars 1 ___________________________________________________________________________ 7

OPE-H1A Medical Hungarian 1A - Communication Skills _______________________________________________________ 8

OPE-H1B Medical Hungarian 1B - Language Points ___________________________________________________________ 10

OPE-KP1 Basics of Chemistry 1 ___________________________________________________________________________ 12

OPE-SKS Inorganic Chemistry Calculations _________________________________________________________________ 14

2nd semester

OPE-BO2 Biophysics Seminars 2 __________________________________________________________________________ 16

OPE-FKS Physical Chemistry Problem Solving Seminar ________________________________________________________ 17

OPE-KP2 Basics of Chemistry 2 ___________________________________________________________________________ 18

ELECTIVE SUBJECTS FOR THE PHARMACEUTICAL BIOLOGY AND MEDICAL THEORETICAL KNOWLEDGE

MODULE

2nd semester

OPE-MOM Molecular Medicine ____________________________________________________________________________ 20

3rd semester

OPE-BEE Basics of Epidemiology _________________________________________________________________________ 22

OPE-EHS Hunger, Satiety and Disturbances of Body Weight Regulation ___________________________________________ 24

OPE-HOS Hormonal Regulatory Mechanisms in Health and Disease _______________________________________________ 26

4th semester

OPE-EMM Molecular Basis of Endocrine Diseases _____________________________________________________________ 28

6th semester

OPE-ASZ The Antimicrobial Drugs and their Clinical Use ______________________________________________________ 30

OPE-KPR Chemoprevention ______________________________________________________________________________ 32

ELECTIVE SUBJECTS FOR THE PHARMACEUTICAL SCIENCE THEORETICAL KNOWLEDGE AND PRACTICAL

SKILLS MODULE

2nd semester

OPE-ETI Pharmacy Ethics _______________________________________________________________________________ 34

OPE-H2A Medical Hungarian 2A - Communication Skills ______________________________________________________ 35

OPE-H2B Medical Hungarian 2B - Language Points ___________________________________________________________ 37

OPE-QAS Quantitative Analytical Chemistry Calculation _______________________________________________________ 39

OPE-SME Spectrometric Identification of Organic Compounds ___________________________________________________ 41

4th semester

OPE-GMK Qualitative and Quantitative Analysis of Drugs from Human Tissue _______________________________________ 43

OPE-TG3 Student Project Research for Students of Pharmaceutist Programme 3 _____________________________________ 45

6th semester

OPE-GFK Physico-Chemical Bases of Drug Action ____________________________________________________________ 46

OPE-STK Basics of Stereochemistry _______________________________________________________________________ 48

OPE-TG4 Student Project Research for Students of Pharmaceutist Programme 4 _____________________________________ 50

7th semester

OPE-SHK Design and Industrial Manufacture of Medicines ______________________________________________________ 51

OPE-T2F Pharmaceutical Biotechnology and its links to Biopharmaceuticals ________________________________________ 53

8th semester

OPE-FAJ Pain and Analgesics ____________________________________________________________________________ 55

OPE-MGT Pharmaceutical Technology of Modified Drug Release _________________________________________________ 57

9th semester

OPE-GST Special Fields of Pharmacology ___________________________________________________________________ 59


3

OPTIONAL SUBJECTS

1st semester

OPF-BBM Introduction to Biometrics _______________________________________________________________________ 61

OPF-BFM Problem Solving in Biometrics ____________________________________________________________________ 62

OPF-DME Cancer is Preventable! __________________________________________________________________________ 64

OPF-FEA Basics of Infectious Disease Epidemiology __________________________________________________________ 66

OPF-HB1 How to Achive Better Grade in Organic Chemistry 1 __________________________________________________ 68

2nd semester

OPF-BMK Methods and Experiments in Molecular Biology ______________________________________________________ 70

OPF-BMM Introduction to Molecular Modelling _______________________________________________________________ 71

OPF-CIR The Cytoskeletal System ________________________________________________________________________ 73

OPF-HB2 How to Achieve Better Grade in Organic Chemistry 2 _________________________________________________ 75

OPF-IZM Molecular Basis of Muscle Function _______________________________________________________________ 77

OPF-PLH The Placebo Effect _____________________________________________________________________________ 79

OPF-VVE Vaccination, Anti-Vaccination Movements: Do More Harm than Good ____________________________________ 81

3rd semester

OPF-BUS Biotechnology from a Business Perspective __________________________________________________________ 83

OPF-GMS Genetically Modified Organisms and Our Health _____________________________________________________ 85

OPF-H3A Medical Hungarian 3A - Basics of Medical Communication for Students of Pharmacy ________________________ 87

OPF-H3B Medical Hungarian 3B - Medical Communication in Practice for Students of Pharmacy _______________________ 89

OPF-MGE Molecular Gerontology _________________________________________________________________________ 91

OPF-SSG Histology Seminar for Pharmacy Students ___________________________________________________________ 93

OPF-TG1 Student Project Research for Students of Pharmaceutist Programme 1 _____________________________________ 95

OPF-TMB Molecular Biology of Tumors ____________________________________________________________________ 96

OPF-TSA Statistical Analysis of Thesis and Student Research Projects _____________________________________________ 98

OPF-TSS Medical Applications of Mass Spectrometry ________________________________________________________ 100

4th semester

OPF-BIN Bioinformatics _______________________________________________________________________________ 102

OPF-CSU Miracles of Living Materials ("Realistic" Biochemistry) _______________________________________________ 104

OPF-H4A Medical Hungarian 4A - Basics of Medical Communication for Students of Pharmacy _______________________ 106

OPF-H4B Medical Hungarian 4B - Medical Communication in Practice for Students of Pharmacy ______________________ 108

OPF-MAS Instrumental Analysis - Seminar _________________________________________________________________ 110

OPF-MMR Nuclear Magnetic Resonance for Dummies _________________________________________________________ 111

OPF-TG2 Student Project Research for Students of Pharmaceutist Programme 2 ____________________________________ 113

OPF-VAA Iron Metabolism: from Molecular Mechanisms to Clinical Consequences _________________________________ 114

5th semester

OPF-EFA Ethnopharmacobotany _________________________________________________________________________ 115

OPF-GKG Gas Chromatography __________________________________________________________________________ 117

OPF-GLK Bioinorganic Chemistry for Pharmacy Students ______________________________________________________ 119

OPF-GMT Drug Metabolism and Drug Toxicity ______________________________________________________________ 121

OPF-HVS Synthesis of Heterocyclic Compounds and Their Application in Therapy __________________________________ 123

OPF-MME Molecular Medicine ___________________________________________________________________________ 125

OPF-MOD Molecular Diagnostics _________________________________________________________________________ 127

OPF-MOT Molecular Therapies ___________________________________________________________________________ 129

OPF-PRB Protein Biotechnology _________________________________________________________________________ 131

6th semester

OPF-EXT Extraction and Chromatographic Techniques in Medicinal Plant Analysis _________________________________ 133

OPF-MMG Nuclear Magnetic Resonance in Drug Development __________________________________________________ 135


4

7th semester

OPF-KIA Essential Oils and Clinical Aromatherapy __________________________________________________________ 137

8th semester

OPF-GTH Gene Therapy ________________________________________________________________________________ 139

OPF-IVF Infections and Immunity________________________________________________________________________ 141

9th semester

OPF-SUO Emergency Medicine __________________________________________________________________________ 143


5

OPE-BFA PHYSICAL BASIS OF BIOPHYSICS

Course director: DR. EMŐKE BÓDIS, assistant professor

Department of Biophysics

2 credit ▪ midsemester grade ▪ Elective subject for the Basic Module ▪ both semesters semester ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 100 Prerequisites:

Topic

The course addresses the chapters of physics which are necessary for a proper understanding of Biophysics (lecture and practicals). Beyond theoretical discussions, example problems are solved.

Conditions for acceptance of the semester

Maximum 3 absence is allowed.

Mid-term exams

Making up for missed classes

There is no option.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

Course related information can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu).

- Recommended literature

As a base, any secondary school physics book is useful.

Lectures

Practices

Seminars

1 Mathematical basics. Scalars and vectors

2 Physical quantities and units

3 Newton`s laws

4 Conservation of momentum. Collisions

5 Motion on a straight line. Kinetics

6 Motion on a straight line. Dynamics

7 Circular motion, rotation

8 Oscillations

9 Work and energy. Friction

10 The work-energy theorem. Conservation of mechanical energy

11 Hydrostatics

12 Hydrodynamics

13 First and second law of thermodynamics

14 Thermodynamic potentials

15 Electrostatics

16 Ohm`s law, Kirchhoff`s laws

17 Magnetostatics

18 Magnetic induction

19 Waves

20 Wave- and geometrical optics

21 Atom- and nuclear physics

22 Radioactivity

23 Radiations (radioactive, electromagnetic)

24 Electromagnetic waves

25 Radiation-matter interaction

26 Special radiation-matter interactions

27 Test writing

28 Test writing

http://biofizika.aok.pte.hu/


6

Exam topics/questions

Can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu)

Participants

Dr. Bódis Emőke (BOEAAD.T.JPTE), Dr. Szabó-Meleg Edina (MEEDAA.T.JPTE), Dr. Talián Csaba Gábor (TACRAAO.PTE), Kollár

Veronika Tünde (KOVGACT.PTE), Leipoldné Vig Andrea (VIAFAAO.PTE), Szatmári Dávid (SZDHAAT.PTE), Tóth Mónika Ágnes (TOMIAAT.PTE)



7

OPE-BO1 BIOPHYSICS SEMINARS 1

Course director: DR. ANDRÁS SZILÁRD LUKÁCS, assistant professor


1 credit ▪ midsemester grade ▪ Elective subject for the Basic Module ▪ autumn semester ▪ recommended semester: 1


Course headcount limitations (min.-max.): 5 – 40 Prerequisites: OPA-FI1 parallel

Topic

The objective of the course is to advance the acquisition of knowledge and skills related to Biophysics 1. Object-oriented discussions

and problem solving sessions are organized in interactive small-group seminars.


Maximum of three absences.

Mid-term exams


None. Based on previous agreement with the lecturer the student can attend the seminar with another group another day on the same

week.

Reading material



http://biofizika.aok.pte.hu

- Notes

Damjanovich et al (ed.): Medical Biophysics


Lectures

Practices

Seminars

1 Introduction

2 Diffusion

3 Osmosis. Fluid flow

4 Circulation. Cardiac biophysics. Protein folding

5 Resting membrane potential. Sensory receptors. Action potential

6 Vision. Hearing

7 Cytoskeleton. Motor proteins

8 Structure of striated muscle. Molecular basis of muscle function

9 Foundations of thermodynamics. Laws of thermodynamics

10 Thermodynamic potentials

11 The double nature of light. The structure of the atoms

12 Quantum numers. Spin. Molecular orbitals

13 Laser. X-ray

14 Test writing


Can be found on the departmental website: http://biofizika.aok.pte.hu

Participants

Dr. Kengyel András Miklós (KEAFACO.PTE), Dr. Szabó-Meleg Edina (MEEDAA.T.JPTE), Futó Kinga (FUKIAAT.PTE), Huber Tamás (HUTEAB.T.JPTE), Kollár Veronika Tünde (KOVGACT.PTE), Szatmári Dávid (SZDHAAT.PTE)




8

OPE-H1A MEDICAL HUNGARIAN 1A - COMMUNICATION SKILLS

Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor

Department of Languages for Specific Purposes



Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H1B parallel

Topic

To establish basic skills in reading, writing, listening and speaking Hungarian in preparation for effective medical communication.


Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In

the case of absences up to 25% of total class time, oral examination will have to be taken

Mid-term exams


To be discussed with the course tutor in each individual case.

Reading material



In-house course book: at the homepage of the institute:

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Notes


Lectures

Practices

1 Greeting people, formality and informality

2 Greeting people, formality and informality

3 Addressing people, men and women

4 Addressing people, men and women

5 Starting conversation, the elderly and children

6 Starting conversation, the elderly and children

7 Introducing, equal and unequal relations

8 Introducing, equal and unequal relations

9 Nutritional History Taking

10 Nutritional History Taking

11 Nutrients

12 Nutrients

13 Consolidation

14 Test 1

15 Health Preservation, Sports, Addictions

16 Health Preservation, Sports, Addictions

17 Writing CV, occupation, work

18 Medical Specialties, Consulting Room and Ward

19 Medical Specialties, Consulting Room and Ward

20 Telling CV, family relations

21 Introducing family

22 Introducing family

23 Describing people - Internal and external features

24 Describing people - Internal and external features

25 Health care institutions, consolidation

26 Health care institutions, consolidation

27 Test 2

28 Course Evaluation



9

Seminars


Two written test papers

and oral presentations

Participants

Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné

Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla

Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné

Halmos Éva (MEHHABE.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Csongor Alexandra (CSAAAA.B.JPTE), Tóth Ida (TOIHABE.PTE), Váradi Katalin (VAKHAAE.PTE)


10

OPE-H1B MEDICAL HUNGARIAN 1B - LANGUAGE POINTS





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H1A parallel

Topic

Familiarizing foreign students with basic paradigms used in specific conversations.




Mid-term exams


Participation is obligatory.

Reading material




- Notes


Lectures

Practices

1 Basics of Hungarian Phonetics and Morphology

2 Basics of Hungarian Phonetics and Morphology

3 Personal Pronouns - formal and informal style

4 Personal Pronouns - formal and informal style

5 Constructing Questions - Question Words

6 Constructing Questions - Question Words

7 Numerals - Cardinal, Ordinal, Labels

8 Numerals - Cardinal, Ordinal, Labels

9 Verbs - Definite and Indefinite Conjugation

10 Verbs - Definite and Indefinite Conjugation

11 Expressing Frequency

12 Expressing Frequency

13 Test 1

14 Articles

15 Modality - necessity

16 Modality - necessity

17 Objective Case

18 Objective Case

19 Verbal prefixes

20 Verbal prefixes

21 Expressing Time

22 Expressing Time

23 Expressing Location - Trinity of Directions

24 Expressing Location- Trinity of Directions

25 Dative Case

26 Dative Case

27 Test 2

28 Course Evaluation



11

Seminars


Participants




Halmos Éva (MEHHABE.PTE), Molnár Annamária (MOAFAC.B.JPTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné

Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


12

OPE-KP1 BASICS OF CHEMISTRY 1

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutic Chemistry




Topic

Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating

on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps understanding the chemistry-related compulsory subjects of the modules.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.

Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the

7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.

Mid-term exams


There is no opportunity to make up missed classes.

Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational material, University of Pécs, 2014

- Notes


en.wikibooks.org/wiki/General_Chemistry

Lectures

1 The electronic structure of atom. Elements.

Dr. Perjési Pál

2 The electronic structure of atom. Elements.

Dr. Perjési Pál

3 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

4 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

5 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

6 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

7 Liquids and solutions. Concentrations.

Dr. Perjési Pál

8 Liquids and solutions. Concentrations.

Dr. Perjési Pál

9 Colligative properties.

Dr. Perjési Pál

10 Colligative properties.

Dr. Perjési Pál

11 Chemical thermodynamics I.

Dr. Perjési Pál

12 Chemical thermodynamics I.

Dr. Perjési Pál



13

13 Chemical kinetics.

Dr. Perjési Pál

14 Chemical kinetics.

Dr. Perjési Pál

15 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

16 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

17 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

18 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

19 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

20 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

21 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

22 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

23 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

24 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

25 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

26 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

27 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

28 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

Practices

Seminars


Written tests covering the topics of the lectures.

Participants


14

OPE-SKS INORGANIC CHEMISTRY CALCULATIONS






Topic

This subject is based on the acquired theoretical knowledge on General and Inorganic Chemistry, with adaptation of the principles to

solve chemical problems. The aim of this course to solve chemical calculations related to the lessons of General and Inorganic Chemistry 1 and give a support for easier understanding of the subject.


According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of both tests should be above

60%. One re-take chance is allowed after both tests.

Mid-term exams

Two written exams during the semester.



Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009.


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Calculations, electronic educational material, University of Pécs, 2014

- Notes



Lectures

Practices

Seminars

1 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.

2 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.

3 Stochiometric calculations. Calculation of concentrations.

4 Stochiometric calculations. Calculation of concentrations.

5 Calculation of concentrations, Solubility.

6 Calculation of concentrations, Solubility.

7 Electrolytic dissociation.

8 Electrolytic dissociation.

9 Kolligative properites.

10 Kolligative properites.

11 Thermochemistry (Hess’ Law).

12 Thermochemistry (Hess’ Law).

13 Chemical kinetics. Test 1

14 Chemical kinetics. Test 1

15 pH calculations I.: Hydrolysis of salts.

16 pH calculations I.: Hydrolysis of salts.

17 pH calculations II: Buffers.

18 pH calculations II: Buffers.

19 Solubility equilibria.

20 Solubility equilibria.



15

21 Calculations based on the balancing of redox equations I

22 Calculations based on the balancing of redox equations I

23 Calculations based on the balancing of redox equations II

24 Calculations based on the balancing of redox equations II

25 Calculations on electrochemistry I. Test 2

26 Calculations on electrochemistry I. Test 2

27 Calculations on electrochemistry II

28 Calculations on electrochemistry II


The final grade is established based on the average of each written exams.

Participants

Dr. Almási Attila (ALAFAEO.PTE), Dr. Kuzma Mónika (KUMFABO.PTE)


16

OPE-BO2 BIOPHYSICS SEMINARS 2

Course director: DR. ANDRÁS SZILÁRD LUKÁCS, assistant professor


1 credit ▪ midsemester grade ▪ Elective subject for the Basic Module ▪ spring semester ▪ recommended semester: 2


Course headcount limitations (min.-max.): 5 – 40 Prerequisites: OPA-FI2 parallel

Topic

The objective of the course is to advance the acquisition of knowledge and skills related to Biophysics 2. Object-oriented discussions

and problem solving sessions are organized in interactive small-group seminars.



Mid-term exams


None. After previous agreement with the lecturer the student can attend the seminar with another group another day, the same week.

Reading material



Online materials on departmental website (http://biofizika.aok.pte.hu)

- Notes

Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, 2008


Lectures

Practices

Seminars

1 Radioactivity. Radioactive radiations

2 Spectrophotometry

3 Infrared and Raman spectroscopy

4 Fluorescence spectroscopy

5 Fluorescence anisotropy. FRET

6 Light microscopy, fluorescence microscopy

7 Modern microscopic methods. FRAP

8 Flow cytometry.

9 NMR

10 MRI

11 X-ray diagnostics. CT

12 Gamma-camera, SPECT, PET

13 Ultrasound

14 Test writing


Can be found on the departmental website (http://biofizika.aok.pte.hu)

Participants

Dr. Kengyel András Miklós (KEAFACO.PTE), Dr. Lukács András Szilárd (LUATAA0.PTE), Futó Kinga (FUKIAAT.PTE), Huber

Tamás (HUTEAB.T.JPTE), Kilián Balázsné Raics Katalin (RAKHAAT.PTE), Kollár Veronika Tünde (KOVGACT.PTE)




17

OPE-FKS PHYSICAL CHEMISTRY PROBLEM SOLVING SEMINAR

Course director: DR. LÍVIA NAGY-ZENGŐ, senior research fellow

Faculty of Natural Sciences - Department of General and Physical Chemistry



Course headcount limitations (min.-max.): 3 – 36 Prerequisites: OPA-FZ1 parallel

Topic

This is an elective course, a lecture room practice. It helps the student understanding the ways of calculating quantitative properties of

material, extent of changes and determine important physicochemical parameters. It shows the applicability of the theoretical forms, the

proper using of units in calculations. Showing the applicability of theory it supports bringing close to understanding the principles of

basic course on physical chemistry. The practice is an informal discussion following the physical chemistry I lecturing. The students

obtain problems to solve as home work. These problems are discussed during the practice. During the semester written test are given.

The evaluation is based on the scores. Students taking this course usually can solve easier the calculating problems at the physical chemistry I course.


One class absence can be tolerated.

Mid-term exams


Full solved problems will be handed over in written form for the absent student.

Reading material


P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722


- Notes


P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722

D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2

Lectures

Practices

Seminars

1 The properties of gases: states of perfect gas, the gas laws, units.

2 Basic concepts in thermodynamics, expansion work, internal energy of a system. Application of the first law.

3 Calculation of enthalpy and calorimetry.

4 Calculation of formation enthalpy and the heat capacity (cp, cv).

5 Calculation of the changes in internal energy.

6 Problem solving of entropy, changing of entropy in different processes.

7 Test: the gas laws, the first law, change in internal energy of a system, the heat capacities and entropy

8 Problems of the kinetic model of gases, collision with walls and surfaces.

9 Calculation: First rate chemical reactions.

10 Calculation: First rate chemical reactions, determination of ages by reaction kinetic base.

11 Problem solving of second rate chemical reaction and enzyme reaction

12 Electrochemical calculations: Faraday’s laws, conductivity in electrolytes, Nernst equation, Galvan cells

13 Test: problems fom kinetic model of gases, reaction kinetics and Faraday’s laws.

14 Calculation of electrolysis and corrosion


The solved problems will be handed over in written form for the students at the end of the semester.

Participants

Dr. Nagyné Dr. Zengő Lívia (NAZLAAF.PTE)


18

OPE-KP2 BASICS OF CHEMISTRY 2






Topic

Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating

on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps understanding the chemistry-related compulsory subjects of the modules.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.

Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the

7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.

Mid-term exams



Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational material University of Pécs, 2014

- Notes



J. McMurray, R. C. Fay: Chemistry, 5th edition

Lectures

1 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

2 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

3 Structure of molecules. The valence bond theory

Dr. Perjési Pál

4 Structure of molecules. The valence bond theory

Dr. Perjési Pál

5 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

6 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

7 Bonding in solids

Dr. Perjési Pál

8 Bonding in solids

Dr. Perjési Pál

9 Molecular spectroscopy I. UV-VIS

Dr. Perjési Pál

10 Molecular spectroscopy I. UV-VIS

Dr. Perjési Pál

11 Carbon: structure and reactivity

Dr. Perjési Pál

12 Carbon: structure and reactivity

Dr. Perjési Pál



19

13 Nitrogen: structure and reactivity.

Dr. Perjési Pál

14 Nitrogen: structure and reactivity.

Dr. Perjési Pál

15 Oxygen: structure and reactivity.

Dr. Perjési Pál

16 Oxygen: structure and reactivity.

Dr. Perjési Pál

17 Transition metals: structure and reactivity

Dr. Perjési Pál

18 Transition metals: structure and reactivity

Dr. Perjési Pál

19 Coordination compounds I. Metal-ligand bonding I

Dr. Perjési Pál

20 Coordination compounds I. Metal-ligand bonding I

Dr. Perjési Pál

21 Coordination compounds II. Metal-ligand bonding II

Dr. Perjési Pál

22 Coordination compounds II. Metal-ligand bonding II

Dr. Perjési Pál

23 Coordination compounds III. Isomerism

Dr. Perjési Pál

24 Coordination compounds III. Isomerism

Dr. Perjési Pál

25 Coordination compounds IV. Stability.

Dr. Perjési Pál

26 Coordination compounds IV. Stability.

Dr. Perjési Pál

27 Basic photochemistry

Dr. Perjési Pál

28 Basic photochemistry

Dr. Perjési Pál

Practices

Seminars


Written test covering the topics of the lectures.

Participants


20

OPE-MOM MOLECULAR MEDICINE

Course director: DR. JÓZSEF SZEBERÉNYI, professor

Department of Medical Biology

2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical Biology and Medical Theoretical Knowledge Module ▪ spring semester ▪ recommended semester: 2


Course headcount limitations (min.-max.): 5 – Prerequisites:

Topic

Short description of the course: The course covers overlapping fields of molecular cell biology and clinical genetics, discusses the

significance of molecular genetics in clinical medicine. Main topics: the relationship between genotype and phenotype; human genome

and phenome program; mosaicism; microsatellite instability; genomic imprinting; embryo cloning; gene therapy; ethical aspects of molecular medicine.

The main educational task of the subject: The aim of the course is to develop connections between basic science and clinical medicine;

to convince students that knowledge of molecular biology is essential to understand the pathomechanism of diseases; to give students

the chance to face clinical problems even at the beginning of their medical studies.


According to the Code of Studies

Mid-term exams


None.

Reading material



- Notes


Gelehrter-Collins: Principles of Medical Genetics

Cooper-Mausman: The Cell. A Molecular Approach

Lectures

1 DNA fingerprinting

Dr. Szeberényi József

2 DNA fingerprinting


3 Genotype-phenotype; phenotype-genotype

Dr. Kosztolányi György

4 Genotype-phenotype; phenotype-genotype


5 Mosaicism


6 Mosaicism


7 Human genome project


8 Human genome project


9 The RNA world


10 The RNA world


11 Non-Mendelian monogenic inheritance


12 Non-Mendelian monogenic inheritance



21

13 National holiday


14 National holiday


15 Diseases of protein folding


16 Diseases of protein folding


17 Genetics and environment: epigenetics


18 Genetics and environment: epigenetics


19 Intracellular antibodies


20 Intracellular antibodies


21 Molecular cytogenetics


22 Molecular cytogenetics


23 Cloning of mammals


24 Cloning of mammals


25 Ethical aspects of molecular genetics


26 Ethical aspects of molecular genetics


27 Closing test


28 Closing test


Practices

Seminars


None.

Participants


22

OPE-BEE BASICS OF EPIDEMIOLOGY

Course director: DR. TÍMEA VARJAS, assistant professor

Department of Public Health Medicine

1 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical Biology and Medical Theoretical Knowledge Module ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 1 – 30 Prerequisites: OPA-BM2 completed

Topic

During the semester students are acquainted with the basics of epidemiology and epidemiological studies frequently used in scientific

literature. With this knowledge one can easily elucidate and interpret scientific publications.

The course is recommended for pharmacists and dentists.


Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams

Examination: written test


Based on individual consideration

Reading material



PPT-presentations (Neptun)

- Notes


Lectures

1 Definition, history, goal and concept of epidemiology

Dr. Szabó István

2 Definition, history, goal and concept of epidemiology

Dr. Szabó István

3 Epidemiological indicators and their application (incidence, prevalence)

Dr. Szabó István

4 Epidemiological indicators and their application (RR, OR, statistical significance)

Dr. Szabó István

5 Epidemiological studies

Dr. Szabó István

6 Epidemiological studies

Dr. Szabó István

7 Epidemiology and Evidence Based Medicine

Dr. Szabó István

8 Epidemiology and Evidence Based Medicine

Dr. Szabó István

Practices

1 Basic epidemiological calculations

2 Basic epidemiological calculations

3 Analyzis of selected scientific publications

4 Analyzis of selected scientific publications

Seminars

1 Standardization, Screening

2 Bias, error


Neptun


23

Participants

Dr. Szabó István (SZIGABO.PTE)


24

OPE-EHS HUNGER, SATIETY AND DISTURBANCES OF BODY WEIGHT REGULATION

Course director: DR. LÁSZLÓ LÉNÁRD, professor

Department of Physiology



Course headcount limitations (min.-max.): 5 – 30 Prerequisites: OPA-FI2 completed + OPO-MB2 completed

Topic

Based on recent results, feeding related physiological and pathophysiological mechanisms will be discussed. Students will be trained to

understand these mechanisms. The knowledge based on this course will highly contribute to better understanding further clinical studies on human diseases.

Peripheral and central mechanisms of hunger, satiety, salt appetite and body weight regulation will be discussed. Lectures will include

the following topics: Neural and humoral processes. Peripheral and central glucose-monitoring system. The role of neuropeptides in the control of feeding and hydromineral balance. Pathological processes: obesity, bulimia, anorexia.


Written exams.

Absence from no more than 25% of the lectures.

Mid-term exams


Reading material



- Notes

Notes taken at the lectures.


Lectures

1 Basic parameters: caloric intake, energy expenditure, measurement of food and water intake, body weight and body mass index.

Body weight curves during development, adulthood and senescence.

Dr. Lénárd László

2 Peripheral and central mechanisms of body weight regulation.


3 Endocrine mechanisms: the role of different hormones.


4 Body weight loss, obesity. Long run pathological consequences of obesity.


5 Hunger and satiety. Motivational mechanisms. Overeating, rejection.


6 Hypothalamic dual centers. The role of limbic system in hunger and satiety.


7 Peripheral glucose related signals. The central glucose monitoring system.


8 Food rewarded learning, the role of reinforcement. Aversive learning, the role of conditioned taste aversion in feeding habits.


9 The sight, odor, taste and texture of foods and their detection in the limbic system. Ingestive and rejective mimetic responses and

their genetic determination.


10 The role of monoamines in the regulation of feeding. Similarities of food rewarded learning and addictive behavior. The role of

dopamine and neuropeptides.


11 Orexigenic and anorexigenic neuropeptides.


12 The role of the central angiotensinergic system in drinking and hydromineral balance.



25

13 Childhood obesity and cognitive processes.


14 Anorexia nervosa, bulimia and binge eating. Clinical relevance of animal experiments


Practices

Seminars


Participants


26

OPE-HOS HORMONAL REGULATORY MECHANISMS IN HEALTH AND DISEASE

Course director: DR. MARIETTA VÉRTES, professor emeritus




Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPO-MB2 completed

Topic

The aim of the program is to clarify the role of hormones and hormonal networks in the maintenance of homeostasis and regulation of

body processes including reproduction. The lectures attempts to provide an overview of function of hormonal networks and the integrity of nervous and endocrine regulation in human body.


Maximum of 25 % absence allowed

Mid-term exams


Oral discussion of given chapter

Reading material



- Notes


Greenstein B.: Endocrinology at a Glance, Springer 1999

Williams Textbook of Endocrinology, 2004

Goodman M: Basic Medical Endocrinology, 2000

Greenspan FS, Baxter JD: Basic and Clinical Endocrinology, 2003

Lectures

1 Types of hormones. Hormone synthesis, transport

Dr. Vértes Marietta

2 Mechanism of hormone action, hormone receptors


3 Signal transduction. Regulation of tissue responsiveness to hormones


4 Endocrine and nervous system relationships


5 Hypothalamo-hypophyseal tract


6 Anterior pituitary. Feedback regulation


7 Principles of hormonal integration.


8 Hormonal regulation of fuel metabolism. General concepts


9 Growth hormone and IGF


10 Hormones of pancreas


11 Metabolism in diabetes mellitus


12 Regulatory peptides in the gut


13 Cortisol



27

14 Stress and thyroid hormones


15 Regulation of salt and water balance. General concepts


16 Hypothalamo-neurophyseal system


17 Renin-angiotenzin-aldosteron system


18 Natriuretic hormones


19 Hormones in pregnancy and during fetal development

Dr. Kovács Kálmán András

20 Hormones in pregnancy and during fetal development


21 Menstrual cycle. Contraception


21 Menstrual cycle. Contraception


23 Breast development. Hormones during lactation


24 Ontogeny of endocrine system


25 Hormones and bones


26 Endocrine system and aging


27 Discussion


28 Exams


Practices

Seminars


Written exam, multiple choice questions from lectures

Participants

Dr. Kovács Kálmán András (KOKFAFO.PTE), Dr. Vértes Marietta (VEMMAAP.PTE)


28

OPE-EMM MOLECULAR BASIS OF ENDOCRINE DISEASES

Course director: DR. MARIETTA VÉRTES, professor emeritus





Topic

Endocrinology is the study of hormones, their receptors and the intracellular signalling pathways they invoke. The aim of the program is

to understand the effects of hormones on cellular growth and function and their implications in development of endocrine dysfunction. Explain the molecular and cellular abnormalities in common endocrine-based diseases.



Mid-term exams


Oral discussion of given chapter

Reading material



- Notes


Greenstein B.: Endocrinology at a Glance, Springer 1999

Williams Textbook of Endocrinology, 2004

Goodman M: Basic Medical Endocrinology, 2000

Greenspan FS, Baxter JD: Basic and Clinical Endocrinology, 2003

Lectures

1 Disorders of endocrine system. Hypo- and hyperfunction


2 Disorders of endocrine system. Hypo- and hyperfunction


3 Defect in sensitivity to hormones. Approach to the patient with endocrine disease


4 Defect in sensitivity to hormones. Approach to the patient with endocrine disease


5 Laboratory and imaging studies. Endocrinologic evaluation of the hypothalamo-pituitary axis


6 Laboratory and imaging studies. Endocrinologic evaluation of the hypothalamo-pituitary axis


7 Pituitary disorders: adenomas, Hypopitutarism, hypothalamic dysfunction.


8 Pituitary disorders: adenomas, Hypopitutarism, hypothalamic dysfunction.


9 Hormonal disorders of growth.


10 Hormonal disorders of growth.


11 Disorders of the thyroid


12 Disorders of the thyroid



29

13 Goiter. Hypothyroidism.


14 Goiter. Hypothyroidism.


15 Hyperthyroidism. Autoimmune disorders


16 Hyperthyroidism. Autoimmune disorders


17 Hormonal dysfunction of carbohydrate, protein and fat metabolism


18 Hormonal dysfunction of carbohydrate, protein and fat metabolism


19 Disorders of pancreas


20 Disorders of pancreas


21 Glucocorticoids, Adrenal medulla


22 Glucocorticoids, Adrenal medulla


23 Neural and hormonal integration in control of fluid homeostasis


24 Neural and hormonal integration in control of fluid homeostasis


25 Antidiuretic hormones, Mineral corticoids, Atrial Natriuretic Hormones


26 Antidiuretic hormones, Mineral corticoids, Atrial Natriuretic Hormones


27 Exam


28 Exam


Practices

Seminars


Written exam, multiple choice questions from lectures

Participants

Dr. Kovács Kálmán András (KOKFAFO.PTE), Dr. Vértes Marietta (VEMMAAP.PTE)


30

OPE-ASZ THE ANTIMICROBIAL DRUGS AND THEIR CLINICAL USE

Course director: DR. BÉLA KOCSIS, associate professor

Department of Medical Microbiology and Immunology




Topic

The aim of these lectures is to give a reliable and detailed knowledge about the antimicrobial drugs and their clinical use; to give ideas

how to choose the proper drug for the prophylaxis and therapy of infectious diseases


Mid-term exams


None

Reading material


Jawetz et al.: Medical Microbiology


- Notes


Lectures

1 Introduction, historical data, basic definitions

Dr. Kocsis Béla

2 Characterisation of antimicrobial drugs, chemical structure, their targets

Dr. Kocsis Béla

3 Characterisation of antimicrobial drugs, sensitivity and resistance

Dr. Kocsis Béla

4 Characterisation of antimicrobial drugs, sensitivity and resistance

Dr. Kocsis Béla

5 Pharmacokinetics and pharmacodynamics of anti-infective drugs

Dr. Kocsis Béla

6 The antibiotic prophylaxis.

Dr. Kocsis Béla

7 The empiric antimicrobial therapy

Dr. Kocsis Béla

8 The antimicrobial therapy based on microbiologic result

Dr. Kocsis Béla

9 The choice of best antimicrobial drug

Dr. Kocsis Béla

10 The reasons of an unsuccessful antimicrobial therapy

Dr. Kocsis Béla

11 The antimicrobial drugs in details. The inhibitors of the cell wall biosynthesis Beta-lactams Penicillins

Dr. Kocsis Béla

12 Cephalosporins

Dr. Kocsis Béla

13 Carbapenems, monobactams, glicopeptides

Dr. Kocsis Béla

14 The inhibitors of the protein biosynthesis Aminoglicosides

Dr. Kocsis Béla

15 Tetracyclines Chloramphenicol Macrolides

Dr. Kocsis Béla


31

16 The inhibitors of the nucleic acid biosynthesis Rifampins Sulfonamides

Dr. Kocsis Béla

17 Kinolons Fluorokinolons

Dr. Kocsis Béla

18 The antimycotic drugs

Dr. Kocsis Béla

19 The antimycotic drugs

Dr. Kocsis Béla

20 The antiviral drugs

Dr. Kocsis Béla

21 The antiviral drugs HIV - AIDS

Dr. Kocsis Béla

22 The antiparasitic therapy. The chemoprophylaxis of malaria

Dr. Kocsis Béla

23 The antimicrobial therapy of respiratory and urinary tract infections

Dr. Kocsis Béla

24 Cardiovascular and wound infections, sepsis

Dr. Kocsis Béla

25 Central nervous system, abdominal and enteric infections

Dr. Kocsis Béla

26 Antimicrobial therapy of patients under immunosuppression, pregnancy....

Dr. Kocsis Béla

27 The pharmacological aspects of antimicrobial therapy

Dr. Kocsis Béla

28 The future of antimicrobial therapy

Dr. Kocsis Béla

Practices

Seminars


None

Participants


32

OPE-KPR CHEMOPREVENTION

Course director: DR. TÍMEA VARJAS, assistant professor





Topic

Chemoprevention is the administration of natural or (semi)synthetic agents to prevent, inhibit, or delay the progression of chronic

diseases. The focus is on cancer chemoprevention.

The way from a potent agent to a chemopreventive strategy will also be discussed.

Involving (chemo)preventive interventions in every-day practice could spare valuable life years.


Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.

Examination: test

Mid-term exams

Examination: test


Based on individual consideration

Reading material



PPT-presentations (Neptun)

- Notes


Lectures

1 Introduction; Chemoprevention as a preventive strategy

Dr. Szabó István

2 Introduction; Chemoprevention as a preventive strategy

Dr. Szabó István

3 Finding evidence

Dr. Szabó István

4 Finding evidence

Dr. Szabó István

5 Interventing chronic diseases I

Dr. Szabó István

6 Interventing chronic diseases I

Dr. Szabó István

7 Interventing chronic diseases II

Dr. Szabó István

8 Interventing chronic diseases II

Dr. Szabó István

9 Chemopreventive strategies - antioxidants

Dr. Szabó István

10 Actualities of antioxidants

Dr. Szabó István

11 Natural chemopreventive agents

Dr. Szabó István

12 Natural chemopreventive agents

Dr. Szabó István


33

13 Chemopreventive dietary factors

Dr. Szabó István

14 Chemopreventive dietary factors

Dr. Szabó István

Practices

Seminars


Neptun

Participants


34

OPE-ETI PHARMACY ETHICS

Course director: TIBOR SZOLCSÁNYI, assistant professor

Department of Behavioural Sciences

1 credit ▪ midsemester grade ▪ Elective subjects for the Pharmaceutical Science Theoretical Knowledge and Practical Skills Module ▪ spring semester ▪ recommended semester: 2



Topic

The aim of the course is to help students gain sensitivity to the ethical issues connected to the pharmacy practice. During the course

students learn about the basic ethical principles governing the pharmacist-patient and the pharmacist-physician relationship. Students

also get acquainted with the dilemmas that are raised by the conflict between business and ethics in pharmacy. The most important

concerns of research ethics and some specific ethical issues, like the question of mind-enhancing drugs, are also discussed during the

course.



Mid-term exams


Reading material



Additional materials: Neptun Meet Street

- Notes


Robert Veatch and Amy Haddad (eds.): Case Studies in Pharmacy Ethics, 2nd edition, Oxford University Press, New York, 2008

Lectures

Practices

Seminars

1 Introduction

2 A short history of pharmacy

3 General ethical viewpoints

4 The principle of informed consent in modern health-care

5 The ethics of patient-pharmacist relationship

6 The ethics of physician-pharmacist relationship

7 The conflict between business and ethics in pharmacy

8 The placebo effect and its ethical concerns

9 Dietary supplements, performance- and mind- enhancing drugs

10 Ethical dilemmas raised by the drug therapy of mental disorders

11 Ethical issues in animal experimentation

12 Ethical issues in clinical drug trials

13 Summarizing discussion

14 Test


Participants

Dr. Szolcsányi Tibor (SZTAAJ.B.JPTE)


35

OPE-H2A MEDICAL HUNGARIAN 2A - COMMUNICATION SKILLS





Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPE-H2B parallel + OPE-H1A completed

Topic

This course is meant to serve as a transition between general and specific (doctor-patient) communication skills development.




Mid-term exams


In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material



http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

- Notes


Lectures

Practices

1 Logical relations, comparison

2 Logical relations, comparison

3 Giving orientation, informing people

4 Giving orientation, informing people

5 Giving descriptions, requesting and providing information

6 Giving descriptions, requesting and providing information

7 Cause and consequence

8 Cause and consequence

9 Narratives

10 Narratives

11 Giving advice

12 Giving advice

13 Expressing uncertainty

14 Expressing uncertainty

15 Test 1

16 Test 1

17 Descriptions, warning

18 Descriptions, warning

19 Polite request, command and warning

20 Polite request, command and warning

21 Parts of the human body, pain, basic symptoms

22 Parts of the human body, pain, basic symptoms

23 History taking: presenting complaints, location, direction and character of pain

24 History taking: presenting complaints, location, direction and character of pain

25 Simple examinations, diagnostic procedures

26 Simple examinations, diagnostic procedures

27 Test 2

28 Course evaluation



36

Seminars


Participants




Halmos Éva (MEHHABE.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Csongor

Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


37

OPE-H2B MEDICAL HUNGARIAN 2B - LANGUAGE POINTS





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H2A parallel + OPE-H1B completed

Topic

This course is meant to provide the language basis for advanced communication between doctors and patients.




Mid-term exams



Reading material




- Notes


Lectures

Practices

1 Expressing possessing, genitive case

2 Expressing possessing, genitive case

3 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

4 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

5 Question words, concerning time and location and adverbs of time

6 Question words, concerning time and location and adverbs of time

7 Expressing cause, giving explanation

8 Expressing cause, giving explanation

9 Functions of past tense in medical Hungarian

10 Functions of past tense in medical Hungarian

11 Future tense, modality expressing ability and volition

12 Future tense, modality expressing ability and volition

13 Impersonalization

14 Impersonalization

15 Consolidation test 1

16 Test 1

17 Modality expressing necessity, possibility and prohibition

18 Modality expressing necessity, possibility and prohibition

19 Definite and indefinite conjugation, prefixed verbs

20 Definite and indefinite conjugation, prefixed verbs

21 Imperative forms

22 Imperative forms

23 Giving instructions to patients



26 Consolidation

27 Test 1




38

Seminars


Participants




Halmos Éva (MEHHABE.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Csongor

Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


39

OPE-QAS QUANTITATIVE ANALYTICAL CHEMISTRY CALCULATION






Topic

The Quantitative analytical chemistry calculation course helps students to understand the analytical (titrimetric) calculations. It makes

theoretical backgrounds more understandable.


According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester. The result of both tests should be above 60%.

Mid-term exams

Two written exams during the semester.


Missing written exams should be made up.

Reading material


Harris D.C.: Quantitative Chemical Analysis, 8th ed., W.H. Freeman and Co., New York, 2010


Handouts.

- Notes


Lectures

Practices

Seminars

1 Introduction - Concentrations - Concentration of standard solutions.

2 Introduction - Concentrations - Concentration of standard solutions.

3 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.

4 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.

5 Neutralization analysis - Standardization of a titrant. Titration curve calculations.

6 Neutralization analysis - Standardization of a titrant. Titration curve calculations.

7 Calculation of pH in titration problems I. Hydrolysis of salts.

8 Calculation of pH in titration problems I. Hydrolysis of salts.

9 Calculation of pH in titration problems II. Buffers.

10 Calculation of pH in titration problems II. Buffers.

11 Non-aqueous titration calculations.

12 Non-aqueous titration calculations.

13 Complexometry - Methods for calculating the titration results.

14 Complexometry - Methods for calculating the titration results

15 Complex chemical equilibria - Calculations with the stability constants.

16 Complex chemical equilibria - Calculations with the stability constants.

17 Redox titrations II. - Calculations based on oxidimetry.

18 Redox titrations II. - Calculations based on oxidimetry.

19 Redox titrations I. - Redox titration curve calculations.

20 Redox titrations I. - Redox titration curve calculations.

21 Redox titrations I. - Calculations based on oxidimetry.

22 Redox titrations I. - Calculations based on oxidimetry.

23 Redox titrations III. - Calculations based on reductometry.

24 Redox titrations III. - Calculations based on reductometry.


40

25 Precipitate formation titrations - Calculations for the solubility products.

26 Precipitate formation titrations - Calculations for the solubility products.

27 Gravimetry.

28 Gravimetry.


The final grade is established based on the average of each written exams.

Participants

Dr. Almási Attila (ALAFAEO.PTE), Dr. Kuzma Mónika (KUMFABO.PTE)


41

OPE-SME SPECTROMETRIC IDENTIFICATION OF ORGANIC COMPOUNDS

Course director: DR. CECÍLIA PÁPAY- SÁR, associate professor

Department of Organic and Pharmacological Chemistry



Course headcount limitations (min.-max.): 2 – 10 Prerequisites: OPA-SV1 completed

Topic

The aim of this course is to introduce the students how to identify organic compounds from the complementary information afforded by

three types of spectra: infrared, mass and NMR.



Mid-term exams

The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.


Students can personally consult with the lecturer.

Reading material


Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.


- Notes


Lectures

1 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra.

Dr. Pápayné Dr. Sár Cecília

2 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra


3 Infrared Spectroscopy: Characteristic group absorptions of organic molecules


4 Infrared Spectroscopy: Characteristic group absorptions of organic molecules


5 Infrared Spectroscopy: Solving problems


6 Infrared Spectroscopy: Solving problems


7 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation.


8 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation


9 1H NMR: Chemical shift, simple spin coupling


10 1H NMR: Chemical shift, simple spin coupling


11 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.


12 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.


13 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI.


14 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI



42

15 1H NMR and 13 C NMR: Solving problems


16 1H NMR and 13 C NMR: Solving problems


17 Mass Spectrometry: Mass spectrometer parts, ionization processes

Dr. Kálai Tamás

18 Mass Spectrometry: Mass spectrometer parts, ionization processes

Dr. Kálai Tamás

19 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds.

Dr. Kálai Tamás

20 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds

Dr. Kálai Tamás

21 Mass Spectrometry: Interpretation of the mass spectrum through examples.

Dr. Kálai Tamás

22 Mass Spectrometry: Interpretation of the mass spectrum through examples.

Dr. Kálai Tamás

23 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra.








27 Evaluation, written exam


28 Evaluation, written exam


Practices

Seminars


Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.

Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin coupling, protons on

heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.

Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic compounds.

Identification of simple organic molecules from IR, NMR and mass spectra.

Participants


43

OPE-GMK QUALITATIVE AND QUANTITATIVE ANALYSIS OF DRUGS FROM HUMAN TISSUE

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy

2 credit ▪ midsemester grade ▪ Elective subjects for the Pharmaceutical Science Theoretical Knowledge and Practical Skills Module ▪ autumn semester ▪ recommended semester: 5



Topic

The course provides knowledge about the traceability of active pharmaceutical ingredients in various biological matrices. It discusses

sampling of biological matrices, sample preparation (extraction) methods [LLE, SPE, SPEC, SPME, MEPS], and various chromatographic analyzes [TLC, GC, LC] as well.

The course intends to present the CNS effects of active pharmaceutical ingredients, as well as drugs in the official investigation. The

sampling procedures and techniques are presented, as well as their official confidence circumstances.

The appearance of drug compounds and drugs in biological matrices, and their pharmacokinetic properties are discussed, as well as traceability of live and corpse biological matrices (blood, urine, hair, nails, saliva, or liver, kidney, brain, or cerebrospinal fluid).

After proper selection of analytical tests, the requirements set for a variety of measuring instruments will be discussed. Standard evaluation and communication, as well as the laws and regulations in force in the analytical results complete the course topics.



Mid-term exams

Students have to prove their knowledge of the course material by presenting a selected topic in a short (10 min) talk. The topic should be

related to one of the topics of the course, and students should rely on their knowledge acquired in previous classes.


According to the Code of Studies and Examinations

Reading material


R.C. Baselt: Disposition of Toxic Drugs and Chemicals in Man, 6th ed., Biomedical Publications, Foster City, CA, 2002

A.C. Moffat, M.D. Osselton, B. Widdop: Clarke’s Analysis of Drugs and Poisons, Pharmaceutical Press, London, 2004.


- Notes


R.J. Flanagan, A. Taylor, I.D. Watson, R. Whelpton: Fundamentals of Analytical Toxicology, John Wiley & Sons, Hoboken, NJ, 2007.

Lectures

1 Introduction to Toxicology. Categorization of Toxins I

Dr. Benkő András Antal

2 Introduction to Toxicology. Categorization of Toxins II


3 Effect of Poisons on the Living Body I


4 Effect of Poisons on the Living Body II


5 Investigation in Forensic Laboratories. Sampling rules. I


6 Investigation in Forensic Laboratories. Sampling rules. II


7 Investigation of Non-standard Human Tissues I


8 Investigation of Non-standard Human Tissues II



44

9 Biological Materials Preparation. Extraction Procedures I


10 Biological Materials Preparation. Extraction Procedures II


11 Forensic Toxicological Investigation of Human Samples by Chromatogaphy I


12 Forensic Toxicological Investigation of Human Samples by Chromatogaphy II


13 Criteria and Evaluation. Expert Opinion in Forensic Toxicology I


14 Criteria and Evaluation. Expert Opinion in Forensic Toxicology II


15 Natural Cannabioids (marihuana, hasis, and hasis oil) I


16 Natural Cannabioids (marihuana, hasis, and hasis oil) II


17 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) I


18 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) II


19 First Generation of Amphetamines (ecstasy, speed)


20 Second generation of disco drugs (catinon and derivatives)


21 Opiates (morphine, codeine, heroine) I


22 Opiates (morphine, codeine, heroine) II


23 Cocaine


24 Body-pack Syndroma.


25 Final Student ppt Presentation I


26 Final Student ppt Presentation II


27 Final Student ppt Presentation III


28 Final Student ppt Presentation IV


Practices

Seminars


10 min ppt presentation based on an international forensic science article

Participants


45

OPE-TG3 STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 3

Course director: DR. GYÖRGYI HORVÁTH, associate professor




Course headcount limitations (min.-max.): 1 – 50 Prerequisites: phaTDK-2 completed

Topic

The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we

wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’ Research Society.


The continuous student’s work is recommended. The prerequisite of this course (TDK 3): registration of the student in the database of

Students’ Research Society and the fulfilment of the Student Project Research for Students of Pharmaceutist Programme 2 course. The

continuous enrolment of consecutive courses can be stopped and continued in further semesters.

Mid-term exams

- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of

the semester.

- Introduction of original article published in national and/or international journals (student is co-author) at the end of 13th week of the

semester.

- Participation on Students’ Research Conference.

- Among the three conditions, one of them should be made at least.


There is no possibility.

Reading material



- Notes


ScienceDirect database

Lectures

Practices

1-24 Research.

Seminars


Not applicable.

Participants

Dr. Horváth Györgyi (HOGAAA.T.JPTE)


46

OPE-GFK PHYSICO-CHEMICAL BASES OF DRUG ACTION

Course director: DR. ZSUZSANNA ROZMER, assistant professor





Topic

The main objective of this course is to expand the knowledge in physico-chemical characterization of drug molecules and drug targets for better understanding the drug action.



Mid-term exams

Written exam


None

Reading material



Lecture notes

- Notes


Vogel HG: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, Springer, 2006

Lectures

1 Molecular bases of biological actions. Structural characteristics of drug targets.

Dr. Rozmer Zsuzsanna

2 Molecular bases of biological actions. Structural characteristics of drug targets.


3 Receptors as drug targets.


4 Receptors as drug targets.


5 Enzymes as drug targets.


6 Enzymes as drug targets.


7 Transporters and ion channels as drug targets.


8 Transporters and ion channels as drug targets.


9 Nucleic acids as drug targets.


10 Nucleic acids as drug targets.


11 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.


12 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.


13 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.


14 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.



47

15 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.


16 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.


17 Physicochemical characteristics of drugs. Solubility.


18 Physicochemical characteristics of drugs. Solubility.


19 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.


20 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.


21 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.


22 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.


23 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.


24 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.


25 In silico ADME modelling. In vitro and in vivo tests.


26 In silico ADME modelling. In vitro and in vivo tests.


27 Physicochemical characteristics of drugs. Metabolic stability.


28 Physicochemical characteristics of drugs. Metabolic stability.


Practices

Seminars


Written test, questions available from the teacher

Participants


48

OPE-STK BASICS OF STEREOCHEMISTRY

Course director: DR. IMRE HUBER, senior research fellow




Course headcount limitations (min.-max.): 5 – 15

Prerequisites: OPA-SK2 completed + OPG-GK1 completed + OGABA2 completed

Topic

In the frame of this topic we will provide an overview about fundamentals of stereochemical definitions and processes. The students will

receive the most important knowledge about stereochemistry, with what they can understand the different binding types of drugs to their place of biological action.



Mid-term exams

Students will have to write a written test at the end of the semester.


In case of absences the students must follow up with self-education!

Reading material



Lecture notes provided by the lecturer.

- Notes



K.-H. Hellwich, C. D. Siebert: Stereochemistry workbook, 191 problems and solutions, Springer, 2006.

Lectures

1 Introduction, confoguration, conformation definitions.

Dr. Huber Imre

2 Chirality, asymmetry.

Dr. Huber Imre

3 Asymmetric syntheses

Dr. Huber Imre

4 Fischer projection, CIP system.

Dr. Huber Imre

5 Diastereomers, enantiomers.

Dr. Huber Imre

6 Epimers, eutomers, distomers.

Dr. Huber Imre

7 Homochirality, inversion, meso-isomers.

Dr. Huber Imre

8 Newman projection.

Dr. Huber Imre

9 Optical purity.

Dr. Huber Imre

10 Prochirality, prostereoisomerism.

Dr. Huber Imre

11 Racemate, racemisation.

Dr. Huber Imre

12 Retention in stereochemistry.

Dr. Huber Imre


49

13 Stereoselectivity, stereospecificity.

Dr. Huber Imre

14 Summary, written test.

Dr. Huber Imre

Practices

Seminars


These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the corresponding answers, parallel.

Participants


50

OPE-TG4 STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 4





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPE-TG3 completed

Topic







Mid-term exams


the semester.

- Introduction of an article published in a national and/or international journal (student is co-author). It must be sent to the course

supervisor at the end of 13th week of the semester.

- Oral presentation at the Students’ Research Conference.

- Dean’s thesis

- Among the four conditions, one of them should be made at least.


There is no possibilities.

Reading material



- Notes


ScienceDirect database.

Lectures

Practices

1-24 Research.

Seminars


No applicable.

Participants



51

OPE-SHK DESIGN AND INDUSTRIAL MANUFACTURE OF MEDICINES

Course director: DR. SZILÁRD PÁL, assistant professor

Department of Pharmacotechnology



Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-BFM completed + OPG-GT2 completed

Topic

During the course, the process of the design of modified drug delivery systems is acquired by the students based on the theory and

practice of biopharmaceutical including examinations of dosage forms. The course consists of theoretical lectures and seminars.


- participation on the lectures

- accepted work reports

- accepted written assessments

Mid-term exams


Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and

work reports.

Reading material



- Notes


Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare

Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone

Lectures

1 Floating drug delivery, Targeted Drug Delivery Systems

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

5 Introduction of modified drug delivery

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

9 Targeted Drug Delivery Systems

Dr. Pál Szilárd


Dr. Pál Szilárd


52


Dr. Pál Szilárd


Dr. Pál Szilárd

13 Pulsative Drug Delivery Systems

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

17 Dissolution, lecture and practice

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

21 From molecule to the preparition

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

25 Test

Dr. Pál Szilárd

26 Test

Dr. Pál Szilárd

27 Assessment

Dr. Pál Szilárd

28 Assessment

Dr. Pál Szilárd

Practices

Seminars


www.gytsz.pte.hu (website of the Institute)

Participants

Dr. Dévay Attila (DEAHABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)

http://www.gytsz.pte.hu/


53

OPE-T2F PHARMACEUTICAL BIOTECHNOLOGY AND ITS LINKS TO BIOPHARMACEUTICALS

Course director: DR. JUDIT PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology




Topic

The aim of this course is to introduce students to the science of pharmaceutical biotechnology and its links to biopharmaceuticals.



Mid-term exams

Writing test



Reading material



- Notes

Lecture notes

Lecture materials available on CooSpace


Lectures

1 Pharmaceuticals, biologics and biopharmaceuticals - link to Biotechnology. An introduction.

Dr. Kvell Krisztián

2 Protein structure and its importance of engineering biopharmaceuticals


3 Gene manipulation and recombinant DNA technology 1: Nucleic acid manipulation


4 Gene manipulation and recombinant DNA technology 2: Recombinant production of therapeutic proteins.


5 Gene manipulation and recombinant DNA technology 3: Nucleic acid manipulation.


6 Biotechnological methodology in drug development 1

Dr. Pongrácz Judit


Dr. Pongrácz Judit


Dr. Pongrácz Judit

9 Sources and upstream processing 1

Dr. Pongrácz Judit

10 Sources and upstream processing 2

Dr. Pongrácz Judit

11 Downstream processing 1

Dr. Járomi Luca

12 Downstream processing 2

Dr. Járomi Luca

13 Product analysis

Dr. Járomi Luca

14 The cytokines: the interferon family

Dr. Járomi Luca


54

15 Cytokines: Interleukin and tumor necrosis factor

Dr. Járomi Luca

16 Growth factors

Dr. Pongrácz Judit

17 Therapeutic hormones

Dr. Pongrácz Judit

18 Recombinant blood proteins and therapeutic enzymes

Dr. Pongrácz Judit

19 Antibodies in diagnostics and therapy

Dr. Pongrácz Judit

20 Vaccines and adjuvants

Dr. Pongrácz Judit

21 Vaccine production

Dr. Pongrácz Judit

22 Nucleic acid-based therapeutics. Gene therapy.


23 Nucleic acid-based therapeutics. Recombinant viruses in cancer therapy.

Dr. Pongrácz Judit

24 Cell-based therapeutics


25 Test systems for toxicology

Dr. Járomi Luca

26 Test systems for efficacy

Dr. Járomi Luca

27 Nanotechnology

Dr. Pongrácz Judit

28 Legal aspects of healthcare-related Biotechnology

Dr. Pongrácz Judit

Practices

1 Principals of gene cloning - using the NCBI database

2 Cloning a specific gene - a practical approach 1



5 Culturing organisms for protein production

6 Culturing organisms for protein production

7 Selection and application of organisms for protein production

8 Protein purification for therapeutic application 1

9 Protein purification for therapeutic application 2

10 Technical approach for monoclonal antibody production 1

11 Technical approach for monoclonal antibody production 2

12 Testing toxicity using methodology of biotechnology

13 Efficacy testing using methodology of biotechnology

14 Nanotechnological methods

Seminars


CooSpace

Participants

Dr. Járomi Luca (JALGAAT.PTE), Dr. Kvell Krisztián (KVKFAAO.PTE)


55

OPE-FAJ PAIN AND ANALGESICS

Course director: DR. GÁBOR PETHŐ, professor

Department of Pharmacology and Pharmacotherapy



Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GH1 completed

Topic

The aim of the course is to give an integrative overview on the physiological, pathophysiological and pharmacological aspects of pain.

Major tasks are to (i) provide information on peripheral and central mechanisms of pain and hyperalgesia; (ii) describe the major features

of existing analgesics including opioids, non-steroidal antiinflammatory agents and adjuvant analgesics; (iii) outline novel targets for development of analgesic drugs. The course will also help students to prepare for the exams in Pharmacology 2 and 3.



Mid-term exams

Midsemester grade will be given.


There is no way to make up for missed lectures.

Reading material



The material of the lectures is available in PDF format at the Intranet site of the Department of Pharmacology and Pharmacotherapy.

- Notes


Lectures

1 Basic terms related to pain and nociceptors

Dr. Pethő Gábor

2 Features of capsaicin-sensitive nociceptors

Dr. Pethő Gábor

3 Peripheral mechanisms of hyperalgesia

Dr. Pethő Gábor

4 Central mechanisms of hyperalgesia and allodynia

Dr. Pethő Gábor

5 Features of neuropathic pain

Dr. Pethő Gábor

6 Pharmacology of non-steroidal antiinflammatory analgesic drugs I

Dr. Pethő Gábor

7 Pharmacology of non-steroidal antiinflammatory analgesic drugs II

Dr. Pethő Gábor

8 Pharmacology of opioid analgesics I

Dr. Pethő Gábor

9 Pharmacology of opioid analgesics II

Dr. Pethő Gábor

10 Adjuvant analgesics

Dr. Pethő Gábor

11 New targets for development of analgesics I

Dr. Pethő Gábor

12 New targets for development of analgesics II

Dr. Pethő Gábor


56

Practices

Seminars


No exam questions are given. The essay questions of the written exam are based on the material presented.

Participants


57

OPE-MGT PHARMACEUTICAL TECHNOLOGY OF MODIFIED DRUG RELEASE

Course director: DR. SZILÁRD PÁL, assistant professor

Department of Pharmacotechnology



Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-GT4 parallel

Topic

Students can get acquainted in details with modified drug delivery technologies and special industrial drug manufacture (3D printing,

manufacture of multi-layer tablets and osmotic preparations) and the importance of pharmaceutical excipients. Student will learn special manufacturing technologies through the demonstration of dosage forms already available in the pharmaceutical therapy.



Mid-term exams

During the end semester test 60 % should be reached.



Reading material



- Notes


James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, 2011

Lectures

1 Theory of modified drug release

Dr. Pál Szilárd

2 Importance of excipients, patents of excipient-compositions

Dr. Pál Szilárd

3 Immediate drug-release (OraSolv, DuraSolv, Zydis technology)

Dr. Pál Szilárd

4 Sustained drug-release: Multiparticulate dosage forms I. (sustained release pellets in practice)

Dr. Pál Szilárd

5 Multiparticulate dosage forms II. (MUPS technology)

Dr. Pál Szilárd

6 Matrix systems I. (hydrophilic matrices)

Dr. Pál Szilárd

7 Matrix systems II. (hydrophobic matrices)

Dr. Pál Szilárd

8 Osmotic technology (EOP, OROS, L-OROS, GITS)

Dr. Pál Szilárd

9 Geometry based drug-release (Geomatrix, Procise, Smartrix technology)

Dr. Pál Szilárd

10 Chronotherapeutic systems (Geoclock technology)

Dr. Pál Szilárd

11 Parenterally administered modified drug delivery

Dr. Pál Szilárd

12 Site specific drug release (gastroretentive systems, colon-specific drug delivery)

Dr. Pál Szilárd

13 Halving of tablets, technology of halving-friendly tablets, concept of ,,ghost" tablets

Dr. Pál Szilárd

14 End-year test

Dr. Pál Szilárd


58

Practices

Seminars


http://gytk.pte.hu

Participants

Dr. Pál Szilárd (PASMAAO.PTE)

http://gytk.pte.hu/


59

OPE-GST SPECIAL FIELDS OF PHARMACOLOGY

Course director: DR. GÁBOR PETHŐ, professor

Department of Pharmacology and Pharmacotherapy

1 credit ▪ midsemester grade ▪ Optional module ▪ autumn semester ▪ recommended semester: 9


Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GH1 completed

Topic

The aim of the course is to present those fields of pharmacology that are not covered at all or only partially discussed in the compulsory

courses Pharmacology 1-2-3 because of time limits. These are the following: use of drugs during pregnancy and lactation; significance

of pharmacogenomics in therapy and drug development, pharmacology of retinoids; other drugs used in dermatology; special aspects of

drugs used in urology; use of meta-analysis in evaluation of drugs, clinical significance of basic pharmacodynamic and pharmacokinetic

parameters; special aspects of drugs used by inhalation, basics of chronopharmacology; pharmacology of contrast media, drugs and

chirality. The course wishes to contribute to a better understanding of the use of drugs in the clinical practice and may help students to prepare for the pharmacology exams.



Mid-term exams

Midsemester grade will be given.


There is no way to make up for missed lectures.

Reading material



The material of the lectures is available in PDF format at the Intranet site of the Department of Pharmacology and Pharmacotherapy.

- Notes


Lectures

1 Special aspects of use of drugs during pregnancy and lactation

Dr. Pethő Gábor

2 Significance of pharmacogenomics in therapy and drug development

Dr. Pethő Gábor

3 Use of meta-analysis in evaluation of drugs

Dr. Pethő Gábor

4 Drugs and chirality

Dr. Pethő Gábor

5 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases I

Dr. Pethő Gábor

6 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases II

Dr. Pethő Gábor

7 Pharmacology of retinoids

Dr. Pethő Gábor

8 Drugs (other than retinoids) used in dermatology

Dr. Pethő Gábor

9 Urological pharmacology I

Dr. Pethő Gábor

10 Urological pharmacology II

Dr. Pethő Gábor

11 Pharmacology of contrast media

Dr. Pethő Gábor

12 Basics of chronopharmacology

Dr. Pethő Gábor


60

Practices

Seminars


No exam questions are given. The essay questions of the written exam are based on the material presented.

Participants


61

OPF-BBM INTRODUCTION TO BIOMETRICS

Course director: DR. LÁSZLÓ PÓTÓ, associate professor

Institute of Bioanalysis

1 credit ▪ midsemester grade ▪ Optional module ▪ both semesters semester ▪ recommended semester: 1



Topic

Exploring data (using graphs and numbers) are usually handled as one-lesson ‘first chapter’ by basic statistical courses. This is, because

a first course in statistics introduces many new skills. It also introduces some new ideas, that all are ‘hard to understand’ for students.

The new approach is to make a solid foundation to learn statistics by a more thorough introduction to those: The course tries to make

clear a few of these fundamental ideas of statistics - limited to understanding and working with data. An improved skill for exploring data is useful not only at your classes and your future job but in the everyday life as well.


Active participation at the classes; maximum one missed class.

Mid-term exams


One extra class

Reading material



- Notes

László Pótó: Biometrics, workbook, Pécs, 2016


1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005 and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H. Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 Probability examples 1

2 Probability examples 1

3 Probability examples 2 - discrete distributions

4 Probability examples 2 - discrete distributions

5 Exploring data by graphs - 1




9 Exploring data by numbers - sample measures 1




13 The normal distribution

14 The normal distribution

Seminars


No exam - but active participation on the classes is a must.

Participants

Dr. Pótó László (POLGABO.PTE)


62

OPF-BFM PROBLEM SOLVING IN BIOMETRICS

Course director: DR. LÁSZLÓ PÓTÓ, associate professor





Topic

Give a chance to have more practice to solve problems in Biometrics using PC and the SPSS software in the computer room. This was a

regular need of the students earlier since the special way how a MD should handle the typical medical problems (special way of thinking)

was not founded by the secondary school education. This foundation is an important focus point of the Biometrics course. It seems, the weekly 1+1 lectures were not enough for most of the students for completing this important goal: To develop some brand new skills.

This course offers an organized way for that extra practices. It offers also some ‘brushing up’ chances for those who has completed

Biometrics earlier.


Active participation on the classes

Maximum one missed class

Mid-term exams


One extra class

Reading material



- Notes

László Pótó: Biometrics, workbook, Pécs, 2016.


1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015. or

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005 and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H. Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 The Confidence Interval of the expected value

2 The Confidence Interval of the expected value

3 The one sample (and the paired samples) t test

4 The one sample (and the paired samples) t test

5 The CI and the hypothesis testing - the type one and type two errors.

6 The CI and the hypothesis testing - the type one and type two errors. MDM basics 1.

7 The independent samples t test

8 The independent samples t test

9 The linear regression

10 The linear regression

11 The contingency tables - the chi squares test

12 The contingency tables - the chi squares test

13 The nonparametric tests

14 The nonparametric tests. MDM basics 2.

Seminars


No exam but active participation on the classes is a must.


63

Participants

Dr. Pótó László (POLGABO.PTE)


64

OPF-DME CANCER IS PREVENTABLE!

Course director: DR. ISTVÁN KISS, professor





Topic

One of the major challenges for the health care system of the 21st century is the high number of cancer caused deaths. Over the past

decades, despite a significant development on the field of medicine, the prognosis of this disease is still not satisfactory. Thus prevention

has a key role in in the fight against cancer. The course gives a description on the different types of cancer their major risk factors for a

more detailed understanding. Methods of cancer prevention will be described and emphasized - including theoretical knowledge and a practical guide as well. During the course the results of most recent human epidemiological studies on cancer will also be described.


Participation in lectures and practicals is obligatory which is registered. Absences should not exceed 4x45 min. Otherwise signature of

grade book is denied.

Mid-term exams


There are no make-up classes.

Reading material



Educational material uploaded on Neptun.

- Notes


Robert Weinberg (ed.): The Biology of Cancer, Garland Science 2006 ISBN 0815340788

Boffetta P., La Veccia: Neoplasms 2009. In Detels R, Beaglehole R, Lansang MA and Gulliford M (eds.) Oxford Textbook of Public

Health, 5th ed., Oxfort University Press

Lectures

1 Cancer in the 21st century

Dr. Kiss István

2 Cancer in developing and developed countries

Dr. Kiss István

3 The process of carcinogenesis I

Dr. Kiss István

4 The process of carcinogenesis II

Dr. Kiss István

5 Characteristics of cancer cells

Dr. Kiss István

6 Molecular epidemiology of cancer

Dr. Kiss István

7 The most important cancer risk factors in general I

Dr. Kiss István

8 The most important cancer risk factors in general II

Dr. Kiss István

9 Lung cancer (development, risk factors, prevention) I

Dr. Kiss István

10 Lung cancer (development, risk factors, prevention) II

Dr. Kiss István

11 Colorectal cancer (development, risk factors, prevention) I

Dr. Kiss István

12 Colorectal cancer (development, risk factors, prevention) II

Dr. Kiss István


65

13 Breast cancer (development, risk factors, prevention) I

Dr. Kiss István

14 Breast cancer (development, risk factors, prevention) II

Dr. Kiss István

15 Prostate cancer (development, risk factors, prevention)

Dr. Kiss István

16 Head and neck cancer (development, risk factors, prevention)

Dr. Kiss István

17 Pancreatic cancer (development, risk factors, prevention)

Dr. Kiss István

18 Gastric cancer (development, risk factors, prevention)

Dr. Kiss István

19 Liver cancer (development, risk factors, prevention)

Dr. Kiss István

20 Cervical cancer (development, risk factors, prevention)

Dr. Kiss István

21 Ovarian cancer (development, risk factors, prevention)

Dr. Kiss István

22 Skin cancer and melanoma malignum (development, risk factors, prevention)

Dr. Kiss István

23 Leukemia (development, risk factors, prevention)

Dr. Kiss István

24 Less frequent tumors (development, risk factors, prevention)

Dr. Kiss István

25 Genetics, genomics and epigenetics in cancer prevention I

Dr. Kiss István

26 Genetics, genomics and epigenetics in cancer prevention II

Dr. Kiss István

Practices

Seminars

1 Recommendations I

2 Recommendations II


Neptun

Participants

Dr. Kiss István (KIIFAD.A.JPTE)


66

OPF-FEA BASICS OF INFECTIOUS DISEASE EPIDEMIOLOGY

Course director: DR. ISTVÁN KISS, professor





Topic

However the morbidity and mortality caused by infectious diseases has significantly declined in the developed countries in the last

century due to the effective prevention methods, their complete elimination is not possible, infectious diseases are still part of our

everyday life. The spread of infectious diseases could be controlled by timely identification, proper investigation and by targeted

interventions. Aim of the course is to present the special characteristics of infectious diseases, and of infectious disease epidemiology;

basics and functioning of surveillance systems, the basics and steps of an outbreak investigation, and epidemiological methods used

during the investigation.


The participation in the lectures, seminars, practises is obligatory (a catalogue should be signed), a maximum of 3x45 min absence is

acceptable, above the signature will be rejected.

Mid-term exams


None

Reading material



- Notes


Heymann (ed.): Control of Communicable Diseases Manual

Mikanatha, Lynfield, Van Beneden, de Valk (eds.): Infectious Disease Surveillance

Lectures

1 Special characteristics of infectious diseases

Dr. Prantner Ida

2 Basics of infectious disease epidemiology I

Dr. Prantner Ida

3 Basics of infectious disease epidemiology II

Dr. Prantner Ida

4 Methods used in infectious disease epidemiology

Dr. Prantner Ida

5 Basic principles of surveillance

Dr. Prantner Ida

6 Infectious disease surveillance

Dr. Prantner Ida

7 Basics and steps of outbreak investigation I

Dr. Prantner Ida

8 Basics and steps of outbreak investigation II

Dr. Prantner Ida

Practices

1 Use of epidemiological knowledge in practice I (definitions, surveillance data interpretation, analysis)

2 Use of epidemiological knowledge in practice II (Data collection, analysis, graphical interpretations)

3 Use of epidemiological knowledge in practice III (analytic studies)

Seminars

1 Investigation of a food-borne outbreak I

2 Investigation of a food-borne outbreak II

3 Investigation of a food-borne outbreak III


67


Participants

Dr. Prantner Ida (PRIFAAO.PTE)


68

OPF-HB1 HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 1

Course director: DR. BALÁZS BOGNÁR, assistant professor





Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Reaction mechanisms in organic chemistry

2. Projection structures, radical substitution

3. Electrophilic addition

4. Electrophilic aromatic substitution

5. Nucleophilic substitution 1, alkyl halides

6. 1. test

7. Nucleophilic substitution 2, organometallics, alcohols, phenols, ethers.

8. Aromatic nucleophilic substitutions

9. Stereochemistry

10-11. Practice, design and synthetic pathway of complex compounds

12. 2. test



Mid-term exams


Reading material



The worksheets will be handed on the seminar.

- Notes


Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007

Lectures

Practices

Seminars

1 Reaction mechanisms, nucleophilic, electrophilic, radical reagents.

2 Projection structures, Fisher projection, reactions of alkanes.

3 Electrophilic addition, reactions of alkenes.

4 Electrophilic aromatic substitution, reactivity, orientation rules.

5 The two possible mechanisms of nucleophilic substitutions, synthesis and reactions of alkyl halides.

6 First test: radical, nucleophilic and electrophilic substitutions, electrophilic additions.

7 Nucleophilic substitution 2, synthesis and reactions of alcohols, phenols, ethers.

8 Aromatic nucleophilic substitutions: aryl halides, diazonium salts.

9 Stereochemistry, relative and absolute configuration.

10 First practice, design and synthetic pathways of complex compounds.

11 Second practice, design and synthetic pathways of complex compounds.

12 Second test: substitution and addition reactions, stereochemistry.


There is no exam.


69

Participants

Dr. Bognár Balázs (BOBGAAT.PTE)


70

OPF-BMK METHODS AND EXPERIMENTS IN MOLECULAR BIOLOGY

Course director: DR. KATALIN SIPOS, associate professor

Department of Pharmaceutical Biology

1 credit ▪ midsemester grade ▪ Optional module ▪ spring semester ▪ recommended semester: 2



Topic

We will analyze famous and interesting molecular biological experiments and examine the development and everyday importance of

methods used in molecular biology. We will pay special attention for experimental areas of pharmaceutical research. We hope the course material will help the students to develop problemsolving thinking.



Mid-term exams

The course will end with a written exam.


According to personal agreement

Reading material



Scientific articles in English

- Notes


Lectures

Practices

Seminars

1 Methods to follow replication.

2 Molecular biological methods of cell cycle examinations

3 PCR

4 Array methods

5 Blotting methods

6 Labeling methods in the molecular biology

7 Gene regulation in the prokaryotes

8 Gene regulation in the eukaryotes.

9 Genetically modified animals

10 Experimental planning in pharmaceutical research I.

11 Experimental planning in pharmaceutical research II.

12 Real time PCR

13 Methods in cell culture experiments

14 Exam


No extra exam questions. The basis of the exam is the material of the seminars.

Participants

Dr. Pandur Edina (PAEFAA.T.JPTE), Dr. Sipos Katalin (SIKMAAO.PTE), Dudás Réka (DURGAAT.PTE), Poór Viktor Soma (POVFAB.T.JPTE), Varga Edit (VAEQABT.PTE)


71

OPF-BMM INTRODUCTION TO MOLECULAR MODELLING

Course director: DR. FERENC KILÁR, professor




Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-FI1 completed

Topic

The aim of this course is to let the students, applying their knowledge in chemistry and biology, to inspect the structure and internal

dynamics of different molecules ranging from simple organic compound to biological macromolecules. The students will be introduced

to the basic methods of molecular modelling and handling structure databases, as well as the benefits of molecular modelling in biological, medical and pharmaceutical research.



Mid-term exams

Special tasks will be given to each student at the end of the course, and the report will be evaluated.


By personal consultation.

Reading material



- Notes


Alan Hinchliffe: Molecular Modelling for Beginners, Wiley 2008

Lectures

1 Basics on chemical structures.

Dr. Kilár Ferenc

2 Basics on biological structures

Dr. Kilár Ferenc

3 Energy minimization and conformation

Dr. Kilár Ferenc

4 The forces between molecules

Dr. Kilár Ferenc

5 Modelling methods and molecular mechanics

Dr. Kilár Ferenc

6 Modelling of protein-ligand interaction

Dr. Kilár Ferenc

7 Use of molecular modelling in drug discovery

Dr. Kilár Ferenc

Practices

1 Basics on computer representation of chemical structures

2 Basics on computer representation of biological structures

3 Calculations in energy minimization and conformation

4 Calculation of forces between molecules

5 Modelling methods and molecular mechanics

6 Modelling of protein-ligand interaction

7 Use of molecular modelling in drug discovery

Seminars


See the website of the Institute


72

Participants

Dr. Hartvig Nóra (HANAAB.T.JPTE), Dr. Kilár Ferenc (KIFGAAO.PTE)


73

OPF-CIR THE CYTOSKELETAL SYSTEM

Course director: DR. BEÁTA BUGYI, assistant professor





Topic

The cytoskeletal system is composed of different proteins networks. The cytoskeleton has versatile structural and functional features,

which are essential for almost all cellular processes. The dysfunctioning of the cytoskeleton can often results in pathological alterations

of cellular functions, which can lead to diseases. In the first module the course we discuss the components and properties of the

cytoskeletal protein networks. The second module lays special emphasis on presenting the pathological alterations of the cytoskeletal system and the underlying diseases.

I. module: Components and functions of the cytoskeleton.

II. module: Pathological alterations and diseases related to the cytoskeleton.

III. module: Biophysical approaches in the investigation of the cytoskeleton.


A maximum of three absences, and a passed test or presentation at the end of the semester.

Mid-term exams


None.

Reading material




- Notes


Jonathon Howard: Mechanics of Motor Proteins and the Cytoskeleton, 2005

S. Trachtenberg: The Prokaryotic Cytoskeleton: A Written Symposium, Journal of Molecular Microbiology and Biotechnology, 2006

Leslie P. Gartner, James L. Hiatt (eds.): Color Textbook of Histology 3, illustrated, revised, Saunders/Elsevier, 2007

Online materials on departmental website (http://biofizika.aok.pte.hu)

Lectures

1 Introduction

Dr. Bugyi Beáta

2 Structural and dynamic properties of cytoskeletal filaments.

Dr. Bugyi Beáta

3 Biological functions of the cytoskeletal filament systems 1.

Dr. Bugyi Beáta

4 Biological functions of the cytoskeletal filament systems 2.

Dr. Bugyi Beáta

5 Cytoskeletal pathology 1: pathogens.

Dr. Kengyel András Miklós

6 Cytoskeletal pathology 2: cancerogenesis.


7 Cytoskeletal pathology 3: myopathies.


8 Microtubule-associated diseases.

Dr. Bugyi Beáta

9 Intermediate filament associated diseases.

Dr. Bugyi Beáta

10 Cytoskeletal filament systems as potential therapeutic targets.

Dr. Bugyi Beáta




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11 Case study 1: cardiac myosin activation, a potential therapeutic approach for systolic heart failure.

Dr. Bugyi Beáta

12 Case study 2: Keratin mutations in Epidermolysis Bullosa Simplex.

Dr. Bugyi Beáta

13 Students’ presentations.

Dr. Bugyi Beáta

14 Students’ presentations.

Dr. Bugyi Beáta

Practices

Seminars


Can be found on the departmental website (http://biofizika.aok.pte.hu).

Participants



75

OPF-HB2 HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 2

Course director: DR. BALÁZS BOGNÁR, assistant professor





Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Revision of addition and substitution reactions

2. Basicity and reactivity of amines

3-4. Reactions of carbonyl compounds, nucleophilic additions, condensations

5. Isomerisations in carbohydrates

6. 1. test

7. Acidity of carboxilyc acids

8. Reactions of carboxilyc acids and their derivatives

9. Aromatic substitutions of heteroaromatics

10-11 Summary of the most important reaction mechanisms with complex problems

12 2. test



Mid-term exams


Reading material



The worksheets will be granted on the seminar.

- Notes


Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994.

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007.

Lectures

Practices

Seminars

1 Summary of the most important reactions from the first semester.

2 Basicity and reactivity of amines.

3 Polarity of the carbonyl bond. Reactions of carbonyl compounds, nucleophilic additions.

4 Polarity of the carbonyl bond. Reactions of carbonyl compounds, condensations.

5 Reactions of carbohydrates: oxidation, reduction, bromination.

6 First test: synthesis and reactions of amines and carbonyl compounds.

7 Acidity of carboxilyc acids, effect of electron sending or withdrawing groups.

8 Reactivity and reactions of carboxilyc acids, amides, anhydrides, esters.

9 Aromatic substitutions of heteroaromatics, reactions of five-membered and six-membered heterocycles.

10 Summary of the most important reaction mechanisms (substitutions, additions) with complex problems.

11 Summary of the most important reaction mechanisms (condensations) with complex problems.

12 Second test: carboxilic acids and their derivatives, heteroaromatics.


There is no exam.


76

Participants

Dr. Bognár Balázs (BOBGAAT.PTE)


77

OPF-IZM MOLECULAR BASIS OF MUSCLE FUNCTION

Course director: DR. DÉNES LŐRINCZY, professor





Topic

The structure of muscle based on light, phase contrast, polarized and electron microscopic observations. Elastic behaviour of passive and

active muscle, types of muscle contractions, muscle force-length relationship. Work done by the muscle, muscle efficiency and heat

production. Thermoelastic behaviour of muscle. Muscle models based on mechanical and structural investigations. Bioelectrical

phenomena, excitation-contraction coupling. Energetics of muscle function, structure of muscle proteins (actin, myosin etc.), analysis of

sliding model. Energetic and spectroscopic investigations in the research of molecular dynamic and thermodynamic background of

muscle function.


The applicants-in the case of more than one absence (up to maximum three absences in which must not be the consultation or test)-should

prepare and will be tested from the missed topics given by the instructor. In the case of more than three absences the course can not be

accepted.

Mid-term exams

Written test at the end of semester.


The applicants-in the case of more than one absence (up to maximum three absences in which must not be the consultation or test)-should

prepare and will be tested from the missed topics given by the instructor.

Reading material



It will be announced at the beginning of the course depending on the possibilities of libraries of Biophysical Department, Faculty of Medicine. A permanent source could be the roaming in the Internet.

- Notes


Lectures

1 The composition of muscle.

Dr. Lőrinczy Dénes

2 The sorts of muscle.


3 The structure of muscle on the basis of light, phasecontrast and polarization microscope.


4 Structure of muscle by ELMI.


5 Sorts of muscle contraction.


6 Elastic behaviour of passive and active muscle.


7 Muscle force and length relationship, Hill`s equation.


8 Work and heat production done by a muscle, efficiency of muscle function.


9 Thermoelastic behaviour of muscle.


10 Muscle models proposed by mechanical and structural investigations.


11 Biochemical basis and energetics of muscle function.



78

12 Bioelectrical phenomena. Action potentials.


13 Nernst equation, G-H-K equation.


14 Voltage- and patch-clamp techniques.


15 Excitation-contraction coupling.


16 Structure of muscle proteins (actin and myosin, actomyosin complex).


17 Discussion of sliding model in details (x-ray diffraction).


18 Molecular dynamic background of muscle contraction (EPR spectroscopy)


19 Muscle in the sport and rehabilitation (wellness).


20 Principle of differential scanning calorimetry.


21 Thermodynamic background of muscle contraction (DSC results)


22 Muscle and levers in locomotion.


23 Free consultation from the topics of course (discussion of any problem).


24 Free consultation from the topics of course (discussion of any problem).


25 Written test.


26 Written test.


27 Discussion of the test, final evaluation of the course.


28 Discussion of the test, final evaluation of the course.


Practices

Seminars


Written test

Participants


79

OPF-PLH THE PLACEBO EFFECT

Course director: TIBOR SZOLCSÁNYI, assistant professor

Department of Behavioural Sciences




Topic

The use of placebo effect has been an inherent part of medicine for thousands of years, and in the recent decades it has become an

inevitable element of medical research due to the introduction of placebo controlled clinical trials. In spite of this fact the research

methodology to measure the effectiveness of placebo effect has been clarified only in the last 10-15 years. At the same time researches

on the neurochemical mechanisms underlying the placebo effect have gained a new impetus. Currently, therefore, we have a much greater

understanding of placebo effect in the context of evidence-based medicine than before, which raises new types of ethical questions as

well. During the course we will examine the different aspects of the phenomenon of placebo effect, and the students will gain knowledge

of the current research results on the field. The main topics of the course: the history of the use of placebo therapies, the role of placebo

effect in medical research, the psycho-social factors that are able to induce placebo effect, neurochemical mechanisms underlying the placebo effect, the ethical implications of the use of placebo effect in medical treatments.



Mid-term exams


According to the Code of Studies and Examinations.

Reading material


Franklin G. Miller; Luna Colloca; Ted J. Kaptchuk: The Placebo Effect: Illness and Interpersonal Healing, Perspect Biol Med. 2009

; 52(4)

Damien G. Finniss; Ted J. Kaptchuk; Franklin G. Miller; Fabrizio Benedetti: Biological, Clinical and Ethical Advances of Placebo

Effects, Lancet 2010; 375; 686-695

Franklin G. Miller; Donald L. Rosenstein: The Nature and Power of the Placebo Effect, Journal of Clinical Epidemiology 59, 2006; 331-335

Fabrizio Benedetti: Mechanisms of Placebo and Placebo-Related Effects across Diseases and Treatments, Annual Review of Pharmacology and Toxicology, Vol. 48; 2008; 33-60.

Jozien M. Bensing; William Verheul: The Silent Healer: The Role of Communication in Placebo Effects, Patient Education and Counseling 80, 2010; 293-299


Additional materials: Neptun Meet Street

- Notes


Fabrizio Benedetti: Placebo Effect, Oxford University Press, Oxford, 2009

Lectures

Lectures

1 Introduction, definitions of placebo effect

Dr. Szolcsányi Tibor

2 The use of placebo effect in the history of medicine


3 The use of placebo effect in the context of medical research: the introduction of randomized placebo controlled clinical trials and

its consequences


4 The methodological and ethical challenges of placebo research


5 The main forms of placebo effect (expectancy based / classical conditioning / affective modulation) and their effectiveness in different diseases


6 The neurochemistry of placebo effect: placebo analgesia



80

7 The neurochemistry of placebo effect: the cardiovascular and the respiratory system, immune response and hormone secretion, Parkinson disease


8 The neurochemistry of placebo effect: further results


9 An overview of the psycho-social factors that are able to induce placebo effect


10 The anthropological and evolutionary background of placebo effect


11 Pain management through psychological interventions and placebo analgesia


12 Ethical implications: how to enhance the placebo effect through improving the physician-patient relationship


13 Ethical implications: the possible role of complementary medicine in the enhancement of placebo effect


14 Written test


Practices

Seminars


Participants


81

OPF-VVE VACCINATION, ANTI-VACCINATION MOVEMENTS: DO MORE HARM THAN GOOD

Course director: DR. KATALIN SZENDI, assistant professor





Topic

Vaccination belongs to one of the most successful modern health care programmes that decreased significantly the number of severe

infectious diseases. In today’s world experts are unable to compete with the media. Several delusions circulate infiltrating the public

opinion related to vaccines. The most susceptible target audience of these beliefs are the half-educated laymen who believe in the media

created pseudoscience. The activity of stubborn anti-vaccine minorities can be dangerous because that may open up new chances of the spread of infectious diseases.

The objective of the course is to deepen the knowledge of vaccinations concerning the background, benefits, achievements and failures,

and the course also serves as a thought provoking initiation for practitioners relating to possible actions against the anti-vaccination

movements.


Participation in lectures and practicals is obligatory which is registered.

Absences should not exceed 15% (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams


There are no make-up classes.

Reading material



Educational material uploaded on Neptun.

- Notes


Stanley A. Plotkin. History of Vaccine Development. Springer 2011.

Vaccine Fact Book 2013. http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf

WHO, UNICEF, World Bank. State of the world’s vaccines and immunization, 3rd ed., Geneva, World Health Organization, 2009.

Lectures

1 History of vaccines and anti-vaccination movements

Dr. Szendi Katalin

2 Epidemiology of infectious diseases, morbidity and mortality rates before and after vaccine introduction. Is there any benefit of vaccination?

Dr. Szendi Katalin

3 Epidemiological studies on vaccination, are there any at all?

Dr. Szendi Katalin

4 Morbidity, mortality, incidence, prevalence. Statistics, data availability, official sources. Are there enough and reliable data to prove the effectiveness or safety of vaccines?

Dr. Szendi Katalin

5 Groups of vaccinations. Why are they compulsory?

Dr. Szendi Katalin

6 Types of vaccinations. Are there any unnecessary ones (e.g. BCG)? Is it possible that the only purpose of the pharmaceutical industry is to increase their profits?

Dr. Szendi Katalin

7 The function of vaccination, types of immunity. Is artificial induction of immunity good for our immune system? Does it result in more benefits if the diseases are fought off in a natural way?

Dr. Szendi Katalin

8 The efficiency of vaccines. Do the European countries with better health indicators also have better epidemiological situation than Hungary? Questions of herd immunity.

Dr. Szendi Katalin

http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf


82

9 Vaccine effectiveness. Are there any positive health effects, or just does the government want to make us believe in counterfeit statistical data?

Dr. Szendi Katalin

10 Vaccination safety, components. Are the ingredients in vaccines dangerous? Do they cause any harm to health? Diversity of conspiracy theories.

Dr. Szendi Katalin

11 Risks of vaccines, vaccination health hazards. Do the vaccines do more harm than good? MMR and autism. Mercury and autism. Aluminium and autism.

Dr. Szendi Katalin

12 Legal background. The legal regulation of vaccines. The pros and cons of compulsory vaccination. What is the point of it? The reason for the existence of free choice.

Dr. Szendi Katalin

Practices

1 Anti-vaccination activities in Hungary and abroad.

2 Do we have to deal with the anti-vaccination movements? Anti-vaccination movements, hazards, duties. Psychology of the anti-vaccination attitudes.

Seminars


Neptun

Participants

Dr. Szendi Katalin (SZKFAPO.PTE)


83

OPF-BUS BIOTECHNOLOGY FROM A BUSINESS PERSPECTIVE






Topic

Interested in biotechnology but have no idea what it is?

„Biotechnology from a Business Perspective” is designed to provide an overview of this relatively young industry. This new course

introduces the scientific background behind biotechnology with a focus on the business aspects of the sector.



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

Practices

Seminars

1 Introduction to biotechnology: basic terms, definitions, historical overview

2 Introduction to biotechnology: basic terms, definitions, historical overview

3 Red (medical), green (agricultural) and white (industrial-environmental) biotech; examples

4 Red (medical), green (agricultural) and white (industrial-environmental) biotech; examples

5 Medical biotechnology: global and local results

- Gene therapy and stem cell therapy

- Cloning and transgenic animals

- Molecular diagnostics, personalized medicine

- Tissue engineering

6 Medical biotechnology: global and local results

- Gene therapy and stem cell therapy

- Cloning and transgenic animals

- Molecular diagnostics, personalized medicine

- Tissue engineering

7 Green biotechnology: potentials and results; Genetically Modified Organisms

8 Green biotechnology: potentials and results; Genetically Modified Organisms

9 Intellectual Property protection, technology transfer

10 Financing of biotech, Venture Capital, Initial Public Offering

11 Business models

12 Spin-off, spin-out companies, other special characteristics of the industry

13 Biotech vs. Big Pharma

14 Case studies

- Genentech, Amgen (USA)

- Solvo, Cyclolab (Hungarian)

http://www.medbiotech.com/


84


www.medbiotech.com

Participants

Dr. Járomi Luca (JALGAAT.PTE), Dr. Kvell Krisztián (KVKFAAO.PTE), Dr. Pongrácz Judit (POJOAAP.PTE), Kovácsné Kósa Judit (SOKDAB.F.JPTE)



85

OPF-GMS GENETICALLY MODIFIED ORGANISMS AND OUR HEALTH

Course director: DR. ZOLTÁN GYÖNGYI, research associate professor





Topic

The application of genetically modified organisms (GMOs) gains more and more ground in food industry. Over the direct health effect,

they have an impact on human economy and health modifying natural environment. The topic provokes social debate, in which, in lack of information, delusions also appear.

The goal of the education is that students receive impartial knowledge of the role of GMOs in our life and their beneficial or possible harmful impact on our health.

During the education students receive a knowledge of molecular background of production of GMOs, their role in agriculture, the

appeared cases and possible health risks, their occurrence in foodstuffs, medical applications, tests, regulations, authorization, economical and social impacts.



Mid-term exams


Consultation with good cause.

Reading material



Lecture slides on Coospace

- Notes


Morgan, Sally: Superfoods: Genetic Modification of Foods (Science at the Edge), Heinemann, 2003 ISBN 1-4034-4123-5.

Lectures

1 The appearance of genetically modified organisms (GMOs)

Dr. Gyöngyi Zoltán

2 Role of GMOs in agriculture


3 Basics of genetically modification I


4 Basics of genetically modification II


5 Possible harmful effect of GMOs to health


6 Background of deaths caused by GM food


7 Prevention of GMO induced health hazard


8 Genetically modification in medicine


9 GMOs in food I.


10 GMOs in food II.


11 Authorization of GMOs


12 Regulation of application



86

13 Impact of GMOs on nature environment and eco farms


14 Effect of GM business on economy, social debates and the flow of information


Practices

Seminars


1. Reasons, why GMOs are created

2. The role of GMOs in the agriculture

3. Impact of GMOs on natural environment and organic farms

4. Molecular basics of genetically modifications

5. Application of genetic modification in the medicine

6. The cause of deaths because of GM food

7. Possible harmful effect of GMOs to health

8. Prevention of harmful effect of GMOs

9. Occurrence of GMOs in foodstuffs, food tests

10. Authorization of GMOs, social debate, flow of information

11. Health impacts of glyphosate

12. Health impacts of Bt toxin

Participants


87

OPF-H3A MEDICAL HUNGARIAN 3A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY






Topic

This course in devoted to the acquisition of language and communicative functions of the basic history taking process and the description of medications.




Mid-term exams



the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material



Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes


Lectures

Practices

1 Family History, social history and previous diseases

2 Family History, social history and previous diseases

3 Complaint and Pain

4 Complaint and Pain

5 Headache, dizziness

6 Perspiration, nausea, vomiting

7 Vision, shortness of breath, cough-Listening comprehension and speaking skills-Listening comprehension and speaking skills

8 Stool, urine

9 Stool, urine

10 Heart complaints, appetite

11 Shivering, fever, oedema

12 Frequent diseases

13 Oesophagus, stomach, gallbladder

14 Bowel diseases, cardiovascular diseases

15 Forms of medications

16 Test 1

17 Types of medications

18 Types of medications

19 Instructions concerning the application of medications: oral medications

20 Instructions concerning the application of medications: oral medications

21 Instructions concerning the application of medications: drops

22 Instructions concerning the application of medications: creams and ointments

23 Instructions concerning the application of medications: creams and ointments

24 Prescriptions

25 Consolidation

26 Consolidation

27 Test 2

28 Consolidation


88

Seminars


Participants


Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hild Gabriella (MAGAAD.B.JPTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE),

Mészégetőné Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


89

OPF-H3B MEDICAL HUNGARIAN 3B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY






Topic

This course serves the skills development based on language and communicative functions acquired in course 3A.




Mid-term exams



Reading material



Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes


Lectures

Practices

1 Family History, social history and previous diseases - Listening comprehension and speaking skills

2 Family History, social history and previous diseases - Listening comprehension and speaking skills

3 Complaint and Pain - Listening comprehension and speaking skills

4 Complaint and Pain - Listening comprehension and speaking skills

5 Headache, dizziness - Listening comprehension and speaking skills

6 Perspiration, nausea, vomiting - Listening comprehension and speaking skills

7 Vision, shortness of breath, cough - Listening comprehension and speaking skills

8 Stool, urine - Listening comprehension and speaking skills

9 Stool, urine - Listening comprehension and speaking skills

10 Heart complaints, appetite - Listening comprehension and speaking skills

11 Shivering, fever, oedema - Listening comprehension and speaking skills

12 Frequent diseases - Listening comprehension and speaking skills

13 Oesophagus, stomach, gallbladder - Listening comprehension and speaking skills

14 Bowel diseases, cardiovascular diseases - Listening comprehension and speaking skills

15 Forms of medications - Listening comprehension and speaking skills

16 Test 1

17 Types of medications - Listening comprehension and speaking skills

18 Types of medications - Listening comprehension and speaking skills

19 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

20 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

21 Instructions concerning the application of medications: drops - Listening comprehension and speaking skills

22 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills

23 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills

24 Prescriptions - Listening comprehension and speaking skills

25 Consolidation

26 Consolidation

27 Test 2

28 Consolidation


90

Seminars


Participants




Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta

Anikó (BEAAAI.B.JPTE), Szántóné Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


91

OPF-MGE MOLECULAR GERONTOLOGY

Course director: DR. KRISZTIÁN KVELL, associate professor




Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPE-MS1 completed

Topic

The curriculum covers physiological aspects of ageing and the molecular background of the ageing process, at cell, intracellular signaling

and nucleic acid level. It highlights the potential molecular intervention possibilities to slow down the ageing process and decrease development of age related diseases.



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Basic Knowledge in Gerontology


2 Aging Theories


3 Mitochondrial Aging


4 Aging and Gene Expression


5 Genetic Background of Longevity


6 Alterations of the Genome due to Aging, Senescence and Cancer


7 Cellular Effects of Acute and Chronic Stress


8 Metabolism and Longevity I


9 Metabolism and Longevity II


10 Senescence-related Intracellular Pathologies


11 Senescence-related Intracellular Pathologies


12 Molecular Mechanisms of Interventions


13 Invited Lecturer I


14 Invited Lecturer II




92

Practices

Seminars


CooSpace

www.medbiotech.com

Participants



93

OPF-SSG HISTOLOGY SEMINAR FOR PHARMACY STUDENTS

Course director: DR. GABRIELLA HORVÁTH-OPPER, assistant professor

Department of Anatomy



Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-AF2 parallel

Topic

The aim of the subject is to complete the knowledge about structure of organ systems. Besides gross anatomy and basic histological

knowledge presented in mandatory anatomy courses, the ‘Histology seminars for pharmacy students’ offers better understanding of histological background of physiological and pathophysiological processes and conditions.


The semester can not be accepted over 2 absences.

Mid-term exams

Multimedia test on last seminar.


Not possible.

Reading material



http://an-server.pote.hu

- Notes


Lectures

Practices

Seminars

1 Basic histotechnics

2 Skin of palm, hairy skin, skin of the armpit

3 Blood smear

4 Red bone marrow

5 Lymphatic organs I

6 Lymphatic organs II

7 Gastrointestinal tract I

8 Gastrointestinal tract II

9 Gastrointestinal tract III

10 Gastrointestinal tract IV

11 Gastrointestinal tract V

12 Gastrointestinal tract VI

13 Respiratory system

14 Kidney

15 Male genitalia I

16 Male genitalia II

17 Female genitalia I

18 Female genitalia II

19 Endocrine glands I

20 Endocrine glands II

21 Nerve cells, peripheral nerve, axon terminals

22 Glia

23 Histological structure of the spinal cord

24 Cerebellum and cortex

25 Eyebulb

26 Optic nerve, lacrimal gland

http://an-server.pote.hu/


94

27 Test

28 Test


http://an-server.pote.hu

Participants

Dr. Horváth-Opper Gabriella (HOGFAFO.PTE), Opper Balázs (OPBFAB.T.JPTE)

http://an-server.pote.hu/


95

OPF-TG1 STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 1






Topic





Students’ Research Society. The continuous enrolment of consecutive courses can be stopped and continued in further semesters.

Mid-term exams

- Topic plan of student’s research project with the confirmation of supervisor

- Introduction of scientific articles found by the student in databases

- The topic plan and articles must be sent for course supervisor at the end of 13th week of the semester.



Reading material



- Notes



Lectures

Practices

1-24 Research.

Seminars


Not applicable.

Participants



96

OPF-TMB MOLECULAR BIOLOGY OF TUMORS

Course director: DR. EDINA PANDUR, assistant professor




Course headcount limitations (min.-max.): 4 – 30 Prerequisites: OPO-GB1 completed + OPO-GB2 completed

Topic

During the course we will discuss the molecular mechanisms of tumor development. We will deal with characteristic features of tumor

cells, and cancers. The function of influencing factors, risk factors, causes, the underlying molecular mechanisms, e.g. mutations, the

role of oncogenes and tumor-suppressor genes, DNA repair, epigenetics and the role of immune system will be discussed in detail. We

will emphasize the function of cell signaling pathways and the failure of apoptosis in tumorigenesis. We will speak about the molecular

mechanisms of invasion and metastasis of tumors, the genes and proteins which have a crucial role in these processes. The participants

will get an insight into the molecular diagnosis, genetic aberrations, and molecular alterations of human cancers. We will discuss the possibilities for cancer therapies, the new approaches such as gene therapy and immunotherapy.


Max. 1 absence

Mid-term exams

One assay, one midterm exam.


Personal consultation

Reading material



Educational materials will be uploaded to Neptune Meet street.

- Notes


Lauren Pecorino: Molecular Biology of Cancer

Wolfgang Arthur Schulz: Molecular Biology of Human Cancers

Lectures

1 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

2 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

3 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer, cell protection mechanisms

Dudás Réka

4 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer, cell protection mechanisms

Dudás Réka

5 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and tissue homeostasis

Poór Viktor Soma

6 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and tissue homeostasis

Poór Viktor Soma

7 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina

8 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina


97

9 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis, replicative senescence and its disturbances in human cancers

Dr. Sipos Katalin

10 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis, replicative senescence and its disturbances in human cancers

Dudás Réka

11 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

12 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

13 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling during tumor invasion; angiogenesis.

Varga Edit

14 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling during tumor invasion; angiogenesis.

Varga Edit

15 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Varga Edit

16 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Varga Edit

17 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

18 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

19 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Dudás Réka

20 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Dudás Réka

21 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Dr. Pandur Edina

22 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Dr. Pandur Edina

23 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

24 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

25 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

26 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

27 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Poór Miklós

28 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Poór Miklós

Practices

Seminars


Participants


98

OPF-TSA STATISTICAL ANALYSIS OF THESIS AND STUDENT RESEARCH PROJECTS

Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor





Topic

This course is for those students who are working on a student research plan or working on their thesis. They can process their own data

and learn the theory of the applied statistical methods as well.


Problem solving, oral report

Mid-term exams


Consultation

Reading material



Own database

- Notes


Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988

Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994

P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994

Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981

Lectures

1 Set the data and complete the database for statistical processing

Borbásné Dr. Farkas Kornélia

2 Select the right statistical methods


3 Learn the theory of the selected methods




5 Interpret the results




7 Conclusions


Practices

1 Set the data and complete the database for statistical processing

2 Select the right statistical methods





7 Conclusions


99

Seminars


Participants

Borbásné Dr. Farkas Kornélia (FAKAAA.T.JPTE)


100

OPF-TSS MEDICAL APPLICATIONS OF MASS SPECTROMETRY

Course director: DR. LÁSZLÓ MÁRK, associate professor

Department of Biochemistry and Medical Chemistry




Topic

In medical sciences, emphasis is increasingly placed on instrumental techniques and accurate, quantitative measurements. This course is

give an overall review about the modern mass spectrometry and it shows the medical applications of the MS in the clinical and diagnostic practice.

Topics:

Introduction to MS. Ionsources, analizators, detectors. Separation techniques. Sample handling. Biomedical sampling. Bioinformatics.

Proteomics, metabolomics and lipidomics. Biomarker discovery. Mass spectrometric imaging techniques.


Written exam. Max. absences: 20%.

Mid-term exams


Not possible.

Reading material



Lecture slides and notes.

- Notes


Vékey et al: Medical Applications of Mass Spectrometry, 2008.

Hoffman et al: Mass Spectrometry, 2007

Lectures

1 Introduction

Dr. Márk László

2 Basics of mass spectrometry

Dr. Márk László

3 Basics of mass spectrometry

Dr. Márk László

4 Ionization techniques

Dr. Márk László

5 Analizators

Dr. Márk László

6 Detectors, The mass spectrum

Dr. Márk László

7 Biomedical sampling

Dr. Márk László

8 Separation techniques, sample preparation

Dr. Márk László

9 Separation techniques, sample preparation

Dr. Márk László

10 Proteomics

Dr. Márk László

11 Proteomics

Dr. Márk László


101

12 Metabolomics

Dr. Márk László

13 Metabolomics

Dr. Márk László

14 Mass spectrometry of endocrine system

Dr. Márk László

15 Mass spectrometry of endocrine system

Dr. Márk László

16 Biomarker discovery

Dr. Márk László

17 Biomarker discovery

Dr. Márk László

18 Lipidomics

Dr. Márk László

19 Lipidomics

Dr. Márk László

20 Proteomics of viruses and bacteria

Dr. Márk László

21 Proteomics of viruses and bacteria

Dr. Márk László

22 Molecular imaging by MS

Dr. Márk László

23 Exam

Dr. Márk László

24 Exam

Dr. Márk László

Practices

Seminars


Ionsources.

Analizators.

Detectors.

Separation techniques.

Sample handling. Biomedical sampling.

Bioinformatics.

Proteomics.

Metabolomics

Lipidomics.

Biomarker discovery.

Mass spectrometric imaging techniques.

MS of endocrine system.

Participants


102

OPF-BIN BIOINFORMATICS

Course director: DR. LÁSZLÓ GRAMA, assistant professor




Course headcount limitations (min.-max.): 5 – 18 Prerequisites: OPO-GB1 completed

Topic

According to a simple definition bioinformatics is molecular biology on a computer. Today, also due to the Human Genome Project, an

incredible amount of information is available on our genes and proteins. What can we use this information for? The aim of bioinformatics

is to organize this information and to help us find and analyze the relevant data. Our course provides an introduction to these. We will seek answers to questions like:

- how can we find the DNA and amino acid sequence of a given protein on the internet?

- how can we distinguish coding and non-coding regions of a gene?

- how can we predict the properties of DNA and protein molecules based on their sequence?

- how can we design a protein cloning experiment?

- how similar is the same protein found in men and mice?

- how can the 3D structure of a protein be predicted?

- how can we visualize and manipulate the 3D structure of a protein?

During the course we will not only discuss the theoretical background of the above (and many other) questions, but students will also be

able to try out all these methods in practice.



Mid-term exams


None.

Reading material




- Notes


Lectures

Practices

1 Introduction

2 Molecular biology basics

3 Introduction to basic tools

4 Protein databases

5 Nucleotide databases

6 Gene and genome databases. Restriction mapping

7 PCR primer design. Plasmid maps

8 Designing a cloning project 1


10 Similarity searches (BLAST)

11 Multiple sequence alignments. Phylogenetic trees

12 3D protein structures

13 Protein structure prediction, computer simulations

14 Bibliography databases (PubMed), working with references



103

Seminars

1 Introduction

2 Molecular biology basics

3 Introduction to basic tools

4 Protein databases

5 Nucleotide databases

6 Gene and genome databases. Restriction mapping

7 PCR primer design. Plasmid maps



10 Similarity searches (BLAST)

11 Multiple sequence alignments. Phylogenetic trees

12 3D protein structures

13 Protein structure prediction, computer simulations

14 Bibliography databases (PubMed), working with references



Participants

Dr. Grama László (GRLHAAO.PTE), Dr. Kengyel András Miklós (KEAFACO.PTE), Dr. Talián Csaba Gábor (TACRAAO.PTE)



104

OPF-CSU MIRACLES OF LIVING MATERIALS ("REALISTIC" BIOCHEMISTRY)

Course director: DR. BALÁZS VERES, associate professor





Topic

The aim of the course is to enlighten and uncover the biochemical background of those topics which are selected as recent „mainstream”

natural science issues. The topic spectrum is wide enough to cover problems from synthetic biology through dopes in sport until toxins

and poisons of plants, fungi and animals. There is a special session about the physical, chemical and medical Nobel prizes from the last decade to get insight to the hottest fields of natural sciences.



Mid-term exams

TVSz


There is no possibility to make up.

Reading material



Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.

- Notes




Lectures

1 Human genome project, gene therapy, epigenetics

Dr. Veres Balázs

2 DNA sequencing, PCR, CSI

Dr. Veres Balázs

3 Playing God: synthetic biology

Dr. Veres Balázs

4 You are what you eat: GMO

Dr. Veres Balázs

5 Superman: doping in sport and brain doping

Dr. Veres Balázs

6 Dependence: biochemistry of alcohol and drugs

Dr. Veres Balázs

7 Falling down: apoptosis, necrosis, autophagy

Dr. Veres Balázs

8 Cancer, AIDS: beyond therapy

Dr. Veres Balázs

9 Biochemistry of neurodegenerative disorders

Dr. Veres Balázs

10 Antibiotics: past, present, future

Dr. Veres Balázs

11 Home delivery: nanoparticles, liposomes

Dr. Veres Balázs

12 Nature strikes back: toxins of plants, fungi and animals

Dr. Veres Balázs


105

13 Ideas behind Nobel prizes I

Dr. Veres Balázs

14 Ideas behind Nobel prizes II

Dr. Veres Balázs

Practices

Seminars


Exam topics are the topics of the lectures during the course.

Participants

Dr. Veres Balázs (VEBAAB.T.JPTE)


106

OPF-H4A MEDICAL HUNGARIAN 4A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY






Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.




Mid-term exams



Reading material



Hand-outs

- Notes


Lectures

Practices

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: painkillers

4 Instructions concerning the use of medications: painkillers

5 Instructions concerning the use of medications: antipyretics

6 Instructions concerning the use of medications: cough medications

7 Instructions concerning the use of medications: antidiabetics

8 Instructions concerning the use of medications: spasmolytics

9 Instructions concerning the use of medications: sleeping pills

10 Instructions concerning the use of medications: steroids

11 Instructions concerning the use of medications: antibiotics

12 Instructions concerning the use of medications: antiinlammatory medications

13 Instructions concerning the use of medications: emetics and aniemetics

14 Instructions concerning the use of medications: eye, ear and nasal drops

15 Instructions concerning the use of medications: medications applied to the skin

16 Test 1

17 Instructions concerning the use of medications: suppository

18 First aid instruments

19 Preparation for the Final Exam in Medical Hungarian








27 Test 2



107

Seminars


Participants







108

OPF-H4B MEDICAL HUNGARIAN 4B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY






Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.



the case of absences up to 25% of total class time, oral examination will have to be taken.

Mid-term exams



Reading material



Hand-outs

- Notes


Lectures

Practices

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: painkillers - Pharmacist-patient dialogue

4 Instructions concerning the use of medications: painkillers - Pharmacist-patient dialogue

5 Instructions concerning the use of medications: antipyretics - Pharmacist-patient dialogue

6 Instructions concerning the use of medications: cough medications - Pharmacist-patient dialogue

7 Instructions concerning the use of medications: antidiabetics - Pharmacist-patient dialogue

8 Instructions concerning the use of medications: spasmolytics - Pharmacist-patient dialogue

9 Instructions concerning the use of medications: sleeping pills - Pharmacist-patient dialogue

10 Instructions concerning the use of medications: steroids - Pharmacist-patient dialogue

11 Instructions concerning the use of medications: antibiotics - Pharmacist-patient dialogue

12 Instructions concerning the use of medications: antiinlammatory medications - Pharmacist-patient dialogue

13 Instructions concerning the use of medications: emetics and antiemetics - Pharmacist-patient dialogue

14 Instructions concerning the use of medications: eye, ear and nasal drops - Pharmacist-patient dialogue

15 Instructions concerning the use of medications: medications applied to the skin - Pharmacist-patient dialogue

16 Test 1

17 Instructions concerning the use of medications: suppository - Pharmacist-patient dialogue

18 First aid instruments -Listening comprehension and speaking skills









27 Test 2



109

Seminars


Participants







110

OPF-MAS INSTRUMENTAL ANALYSIS - SEMINAR

Course director: DR. TÍMEA DERGEZ, assistant professor





Topic

The seminars will be available for helping the students in their studies in Instrumental analysis - both theory and practice.


According to the Faculty rules

Mid-term exams


Reading material



Material can be downloaded from the website of the Institute of Bioanalysis under the

Educational materials link: http://aok.pte.hu/en/egyseg/oktatas/160 (the username and password are provided in the lectures).

Instrumental Analysis. Laboratory Practice. DOI: 10.15170/TTK.2014.00001 (downloadable by the DOI number).

- Notes


D.A. Skoog, F.J. Holler, S.R. Crouch: Principles of Instrumental Analysis

D.G. Watson: Pharmaceutical Analysis (Elsevier)

Lectures

Practices

Seminars

1 Potentiometry

2 Conductometry

3 Atomspectroscopy

4 Molecular spectroscopy

5 Infrared spectroscopy

6 Nuclear magnetic resonance spectroscopy

7 Separation techniques in general

8 Gas-chromatography

9 Liquid chromatography

10 Electrophoretic techniques

11 Capillary electrophoresis

12 Mass spectrometry

13 Coupled separation techniques

14 Data evaluation and error calculation


Participants

Dr. Dergez Tímea (DETCAA.T.JPTE), Dr. Kilár Ferenc (KIFGAAO.PTE), Dr. Poór Viktória (POVAAA.T.JPTE), Páger Csilla

(PACMAAO.PTE)

http://aok.pte.hu/en/egyseg/oktatas/160


111

OPF-MMR NUCLEAR MAGNETIC RESONANCE FOR DUMMIES

Course director: DR. ZOLTÁN BERENTE, associate professor




Course headcount limitations (min.-max.): 1 – 20 Prerequisites: OPA-AN2 completed + OPA-BA1 completed

Topic

Nuclear magnetic resonance offers an exceptionally versatile, non-invasive and non-destructive way for studying intact living organisms.

However, magnetic resonance imaging (MRI), and especially NMR spectroscopy, are strikingly underrepresented among diagnostic

methods. It may be due to regarding the method a strange, obscure if not suspicious „black box”; this way of thinking is far more widespread among graduated medical doctors than it should be.

Take the courage, the time and the effort to take a closer look at nuclear magnetic resonance. Let’s start from scratch and let’s understand

what your fellow students do not bother to understand: what happens with the sample in the magnet during an NMR or MRI experiment, how does it happen and why.

The course covers the theoretical background of the medical diagnostic (imaging and biomarkers) and drug industrial (drug development,

drug analysis) applications of nuclear magnetic resonance with a problem-based attitude and case studies.



Mid-term exams

The student is expected to present a project.


On the judgement of the instructor.

Reading material


http://cis.rit.edu/htbooks/nmr

http://cis.rit.edu/htbooks/mri


- Notes


R. A. de Graaf: In vivo NMR Spectroscopy, Wiley, 1998

http://www.imaios.com/en/e-Courses/e-MRI

http://www.magnetic-resonance.org/

http://eprints.drcmr.dk/37/1/MRI_English_a4.pdf

Lectures

1 The NMR phenomenon. Excitation, relaxation and signal formation

Dr. Berente Zoltán

2 Fourier-transform pulse NMR: Theory and practice

Dr. Berente Zoltán

3 Structure elucidation of small molecules 1. One-dimensional techniques based on coupling through chemical bonds or through the space.

Dr. Berente Zoltán

4 Structure elucidation of small molecules 2. NMR in more dimensions, strategy of structure analysis

Dr. Berente Zoltán

5 Structure elucidation of small molecules 3. NMR in drug development and in drug analysis

Dr. Berente Zoltán

6 Structure elucidation of macromolecules. Intramolecular and intermolecular interactions, structure-activity relationship

Dr. Berente Zoltán

7 Study of energy metabolism using 31P NMR spectroscopy

Dr. Berente Zoltán

8 Study of fuel metabolism using 13C NMR spectroscopy

Dr. Berente Zoltán







112

9 Applications of NMR spectroscopy of other nuclei (19F, 23Na, 87Rb) in life sciences

Dr. Berente Zoltán

10 Statistical NMR spectroscopy: searching for biomarkers

Dr. Berente Zoltán

11 Basics of MR imaging

Dr. Berente Zoltán

12 Current MR imaging techniques

Dr. Berente Zoltán

13 Localised (volume selective) NMR spectroscopy

Dr. Berente Zoltán

14 NMR in solid phase: study of biological membranes

Dr. Berente Zoltán

Practices

Seminars


Participants

Dr. Berente Zoltán (BEZLAAP.PTE)


113

OPF-TG2 STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 2





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG1 completed

Topic







Mid-term exams


the semester.

- Written report on the work performed by the student. It must be sent to the course supervisor at the end of 13th week of the semester.

- Among the two conditions, one of them should be made at least.



Reading material



- Notes



Lectures

Practices

1-24 Research.

Seminars


Not applicable.

Participants



114

OPF-VAA IRON METABOLISM: FROM MOLECULAR MECHANISMS TO CLINICAL CONSEQUENCES

Course director: DR. EDINA PANDUR, assistant professor





Topic

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the

role of iron in the protective mechanisms against bacterial infections. The function of influencing factors of iron metabolism, their effects

and crosstalk between them will be discussed in detail. The roles of iron containing proteins and their functions will be talked over.

During the course we will emphasize the disorders of iron metabolism (iron deficiency, iron overload), their genetic backgrounds and

their therapies. Based on the most actual findings the role of iron in the development of neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease and Huntington’s disease) will be also discussed.


Max. 1 absence

Mid-term exams

One assay and one midterm exam.


Personal consultation

Reading material



The educational materials will be uploaded to Neptune Meet Street

- Notes


Robert Crichton: Iron Metabolism - From Molecular Mechanisms to Clinical Consequences

Lectures

Practices

Seminars

1 Solution chemistry of iron, interactions with other metal ions.

2 The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins

3 Microbial Iron Transport and Metabolism

4 Iron uptake by yeasts

5 Cellular Iron Uptake and Export in Mammals: iron transporters

6 Intracellular Iron Storage and Biomineralisation: ferritin, haemosiderin

7 Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem biosynthesis

8 Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clasters, functions of iron responsive elements and iron regulatory proteins

9 Iron Absorption in Man: functions of luminal factors, regulation of Systemic Iron Balance

10 Pathophysiology of Iron Deficiency and Iron Overload: Acquired and Genetic Disorders of Iron Metabolism, haemochromatosis, thalassemias, secondary iron overload, anemias

11 Iron disorders and Laboratory parameters

12 Iron and oxidative stress: cytoprotective enzymes, antioxidants, aging, role of the immune system

13 Brain iron metabolism, the role of iron in neurodegenerative diseases

14 Assay, exam


Participants

Dr. Nagy Tamás II (NATFABO.PTE), Dr. Pandur Edina (PAEFAA.T.JPTE), Poór Viktor Soma (POVFAB.T.JPTE), Varga Edit (VAEQABT.PTE)


115

OPF-EFA ETHNOPHARMACOBOTANY

Course director: DR. NÓRA PAPP, assistant professor




Course headcount limitations (min.-max.): 4 – 20 Prerequisites: OPO-GN1 completed + OPO-GN2 completed

Topic

Course objective and role of the curriculum:

Several written sources are available on the ethnobotanical usage and pharmaceutical history of medicinal plants from the ancient times.

The course presents a summary about ethnobotanical data focusing on folk therapeutical methods and values of the Mediterranean area,

Transylvania, countries of Europe, Asia, America and Africa completed by the scientific activity and curriculum vitae of ethnobotanists

and researchers in this topic. Students receive an approach about the rules and regularity of the special folk terminology, about practice,

folk customs and symbols in consideration of medicinal plants. Beside the method of an ethnobotanical collection the present state, position and necessity of these surveys are discussed during the course.


Criteria of acceptance of the semester: Satisfactory fulfilment of 2 written tests based on the lectures.

Absences: according to the Code of Studies and Examinations of the Medical School.

Mid-term exams

The required 2 tests can be retaken or corrected in the course.


Reading material



http://aok.pte.hu/en/egyseg/oktatasianyagok/1640

Lectures can be downloaded from Neptun system.

- Notes


Recommended literature:

Cunninham A. B.: Applied Ethnobotany. People, Wild Plant Use and Conservation, Earthscan, London, 2002

Ellen, Davi E., Hatfield, G.: Medicinal Plants in Folk Tradition an Ethnobotany of Britain and Ireland, Timber Press, Portland,

Cambridge, 2004

Lise Manniche: The Ancient Egyptian Herbal, The British Museum Press, London, 1989

Martin G. J.: Ethnobotany. A Methods Manual, Earthscan, London, 2007

Minnis P. E.: Ethnobotany. A Reader, University of Oklahoma Press, U.S.A., 2000

Moerman, Daniel E.: Native American Ethnobotany, Timber Press, Portland, London, 2010

Paye, Gabriell DeBear: Cultural Uses of Plants, The New York Botanical Garden Press, Bronx, New York, 2000

Lectures

1 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

2 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

3 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

4 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

5 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra

6 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra

http://aok.pte.hu/en/egyseg/oktatasianyagok/1640


116

7 Ethnopharmacology of the countries of Africa. The Mediterranean regions (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

8 Ethnopharmacology of the countries of Africa. The Mediterranean regions (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

9 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

10 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

11 Transylvanian ethnobotanical values.

Dr. Papp Nóra

12 Transylvanian ethnobotanical values.

Dr. Papp Nóra

13 Written test I.

Dr. Papp Nóra

14 Written test I.

Dr. Papp Nóra

15 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal

plants.

Dr. Papp Nóra

16 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal plants.

Dr. Papp Nóra

17 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

18 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

19 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

20 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

21 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the knowledge and view of the previous lectures.

Dr. Papp Nóra

22 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the knowledge and view of the previous lectures.

Dr. Papp Nóra

23 Traditional and folk terminology in plant names.

Dr. Papp Nóra

24 Traditional and folk terminology in plant names.

Dr. Papp Nóra

25 Medicinal plants in folk custom and tradition as symbols.

Dr. Papp Nóra

26 Medicinal plants in folk custom and tradition as symbols.

Dr. Papp Nóra

27 Written test II.

Dr. Papp Nóra

28 Written test II.

Dr. Papp Nóra

Practices

Seminars


Participants


117

OPF-GKG GAS CHROMATOGRAPHY

Course director: DR. VIKTÓRIA POÓR, assistant professor




Course headcount limitations (min.-max.): 4 – 10 Prerequisites: OPA-MAN completed

Topic

Key Topics

-practical theory about Gas Chromatography

-how to select and use the carrier gas

-various injection techniques and when to use each

-how to select a GC column

-the operation and selection of an appropriate GC detector

-how to write measuring methods

-how to undertake data analysis

-sampling techniques for GC

-strategies for method development

-introduction to GC & MS advanced techniques

-applications (pharmaceutical application)



Mid-term exams

1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical application)


There is no possibility for retake

Reading material


Modern Analytical Cheymistry, David Harvey


www.aok.pte.hu/bioanalitika

- Notes


Lectures

1 Introduction

Dr. Poór Viktória

2 Parts of gas chromatograph

Gases, injection techniques

Dr. Poór Viktória

3 Columns

Dr. Poór Viktória

4 Detectors

Dr. Poór Viktória

5 Gas chromatography-mass spectrometry

Dr. Poór Viktória

6 Data analysis

Dr. Poór Viktória

7 Applications, pharmaceutical applications

Dr. Poór Viktória

http://www.aok.pte.hu/bioanalitika


118

Practices

1 Introduction

2 How to write a measuring methods

3 How to write a measuring methods

4 Measurements with flame ionization detector

5 Measurements with mass spectrometer detector

6 Data analysis

7 Sample preparation techniques

Seminars


1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical application)

Participants

Dr. Poór Viktória (POVAAA.T.JPTE)


119

OPF-GLK BIOINORGANIC CHEMISTRY FOR PHARMACY STUDENTS

Course director: DR. IMRE HUBER, senior research fellow




Course headcount limitations (min.-max.): 5 – 15

Prerequisites: OPA-AS2 completed + OPA-SK2 completed + OPA-BA2 completed

Topic

We will provide an overview in this block about bioinorganic topics of chemistry, regarding the role of the different elements in medicinal

and pharmaceutical chemistry. Our aim is to offer a concise knowledge also about bioinorganic relations on medical contrast agents like X-ray, tomographic, MR and ultrasound contrast agents. The use of radionuclids in diagnostical methods will be discussed too.



Mid-term exams

Students will have to write a written test at the end of the semester.


In case of absences the students must follow up with self-education!

Reading material




- Notes


Lectures

1 Introduction, The biological importance of non-metals and metals.

Dr. Huber Imre

2 An overview of the elements.

Dr. Huber Imre

3 Rtg-contrast agents.

Dr. Huber Imre

4 Watersoluble nephrothrop Rtg-contrast agents with high osmolality.

Dr. Huber Imre

5 Watersoluble nephrothrop Rtg-contrast agents with low osmolality.

Dr. Huber Imre

6 Watersoluble hepatothrop Rtg-contrast agents.

Dr. Huber Imre

7 Water-insoluble Rtg-contrast agents.

Dr. Huber Imre

8 Contrast agents for MRI.

Dr. Huber Imre

9 Contrast agents for CT.

Dr. Huber Imre

10 Contrast agents for ultrasound.

Dr. Huber Imre

11 Radioactive diagnostics (radionuclids).

Dr. Huber Imre

12 Platinum comlexes in medicin. Chelation therapy.

Dr. Huber Imre

13 Bisphosphonates in medicin.

Dr. Huber Imre

14 Geometry of complexes. Closing written test.

Dr. Huber Imre


120

Practices

Seminars


These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the corresponding answers, parallel.

Participants


121

OPF-GMT DRUG METABOLISM AND DRUG TOXICITY

Course director: DR. ATTILA ALMÁSI, assistant professor





Topic

On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different

drugs are aimed, during the drug absorption, drug transformation and drug elimination.

During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.



Mid-term exams

Acknowledgement of the course is in accord with the Code of Studies and Examinations. At most three absences can be accepted from

the seminaries. In the end of the semester the students write a semester and test. The test is evaluated in percentage and the final grade is

to be established based on this result. The result of the test should be above 60%.


The replacement of the missed test is required.

Reading material



Slides of the lectures.

- Notes


Lectures

1 Introduction. The toxicological aspects of drug metabolism.

Dr. Almási Attila

2 Characteristics of xenobiotics in the body

Dr. Almási Attila

3 Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes).

Dr. Almási Attila

4 Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations).

Dr. Almási Attila

5 Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation).

Dr. Almási Attila

6 Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione conjugation).

Dr. Almási Attila

7 Phase III. transformations (transporters), general molecular mechanism of drug toxicity.

Dr. Almási Attila

8 Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol.

Dr. Almási Attila

9 Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac.

Dr. Almási Attila

10 Toxicity of the troglitazone. Sulfonamide hypersensitivity.

Dr. Almási Attila

11 Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis.

Dr. Almási Attila

12 Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens.

Dr. Almási Attila

13 Metabolic differences between species, genetic polymorphism.

Dr. Almási Attila


122

14 Changes in drug metabolism during pregnancy and at aged people.

Dr. Almási Attila

Practices

Seminars


Participants

Dr. Almási Attila (ALAFAEO.PTE)


123

OPF-HVS SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN THERAPY

Course director: DR. TAMÁS KÁLAI, professor




Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPA-SV1 completed

Topic

Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains

a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of

heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemistry 1 and Organic chemistry 2 course, discusses those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.

Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds

-Saturated heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurrence)

-The pyrrole and indole (synthesis, reactions, occurrence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms

-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)

-Seven membered heterocyclic chemistry

- Heterocycles in supramolecular chemistry

-Heterocyclic compounds in organic synthesis



Mid-term exams

The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a

presentation based on a heterocyclic chemistry paper for an extra grade.


Personal communication. The English program student might visit the parallel Hungarian course to catch up the main reaction equations.

Reading material


Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley


Slides will be given to students as a ppt or pdf files.

- Notes

Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)


Li, J. J. Top 10 drugs Oxford University Press

Lectures

Practices

Seminars

1 Electronic structure of heterocycles

2 Nomenclature of heterocyclic compounds

3 Heterocycles in natural products

4 Common reaction types in heterocyclic chemistry

5 The main synthetic methods of heterocycles

6 Palladium in heterocyclic chemistry


124

7 Three and four membered heterocycles, beta lactams

8 Three and four-membered heterocycles and beta lactams

9 Synthesis of pyrroles and porfirine ring containing compounds

10 Synthesis of indoles, main reactions of indoles.

11 Furans and benzofurans

12 Thiophenes and benzothiophenes

13 1,2-azoles, their synthesis, reactions and their occurrence in drugs

14 1,3-azoles, their synthesis, reactions, occurrence in drugs

15 1st test (general feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles)

16 Six membered heterocycles containing oxygen heteroatom

17 Pyridines (synthesis, reactions, occurrence in drugs and biomolecules)

18 Quinolines, isoquinolines (synthesis, reactions, occurrence in drugs)

19 Synthesis of pyrimidines and their occurrence in medicines

20 Synthesis and reactions of 1,2- and 1,4-diazines

21 Quinoxalines, quinazolines and quinazolinones

22 Synthesis and reaction of purines

23 Nucleic acid based drugs

24 Seven-membered heterocyclic compounds, their role in medicines

25 Heterocycles in supramolecular chemistry

26 Heterocycles in organic synthesis

27 2nd test (6- and 7-membered heterocycles)

28 Short presentations, evaluations


-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds

-Saturated heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurrence)

-The pyrrole and indole (synthesis, reactions, occurrence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms

-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)

-Seven membered heterocyclic chemistry

- Heterocycles in supramolecular chemistry

-Heterocyclic compounds in organic synthesis

Participants

Dr. Kálai Tamás (KATFABP.PTE)


125

OPF-MME MOLECULAR MEDICINE






Topic

Introduction into molecular medicine



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Introduction into molecular medicine

Dr. Pongrácz Judit

2 The genome

Dr. Pongrácz Judit

3 Sequencing of the genome

Dr. Pongrácz Judit

4 Investigation of the human genome with microarrays

Dr. Pongrácz Judit

5 Genes and diseases

Dr. Pongrácz Judit

6 Nuclear receptors

Dr. Pongrácz Judit

7 Personalized genetics

Dr. Pongrácz Judit

8 Immunodeficiencies

Dr. Pongrácz Judit

9 Cancers (introduction)

Dr. Pongrácz Judit

10 Molecular mechanisms of cancer development

Dr. Pongrácz Judit

11 Obesity: introduction

Dr. Pongrácz Judit

12 Genomics of obesity

Dr. Pongrácz Judit

13 Genes involved in development of obesity

Dr. Pongrácz Judit

14 Therapeutic approaches to obesity. Interconnected mechanisms in lipid metabolism

Dr. Pongrácz Judit



126

Practices

Seminars


www.medbiotech.com

Participants



127

OPF-MOD MOLECULAR DIAGNOSTICS






Topic

Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.



Mid-term exams

Writing test



Reading material



- Notes

www.medbiotech.com


Lectures

1 Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.

Dr. Pongrácz Judit

2 Mutations, polymorphisms. The genetic code.

Dr. Pongrácz Judit

3 Mutations, polymorphisms. The genetic code.

Dr. Pongrácz Judit

4 Special mutation consequences.

Dr. Pongrácz Judit

5 Dynamic mutations.

Dr. Pongrácz Judit

6 Mendelian inheritance.

Dr. Pongrácz Judit

7 Multifactorial diseases.

Dr. Pongrácz Judit

8 Examples for monogenic diseases.

Dr. Pongrácz Judit


Dr. Pongrácz Judit


Dr. Pongrácz Judit

11 Pharmacogenetics.

Dr. Pongrácz Judit

12 Molecular testing in oncology.

Dr. Pongrácz Judit

13 Methodology of the molecular diagnostic procedures.

Dr. Pongrácz Judit

14 Methodology of the molecular diagnostic procedures.

Dr. Pongrácz Judit



128

Practices

Seminars


www.medbiotech.com

Participants



129

OPF-MOT MOLECULAR THERAPIES






Topic

Gene therapy, in vivo gene therapy



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Functional genomics I

Dr. Pongrácz Judit

2 Functional genomics II

Dr. Pongrácz Judit

3 Recombinant protein expression

Dr. Pongrácz Judit

4 Gene therapy, in vivo gene therapy

Dr. Pongrácz Judit

5 Ex vivo gene therapy, Therapies based on protein replacement I

Dr. Pongrácz Judit

6 Therapies based on protein replacement II

Dr. Pongrácz Judit

7 Recombinant antibodies and phage phage display technique

Dr. Pongrácz Judit

8 Anti-cytokine therapy (Sepsis)

Dr. Pongrácz Judit

9 Transgene technology and mouse models in modern biological research

Dr. Pongrácz Judit

10 Embryonic and adult stem cells for regenerative medicine I

Dr. Pongrácz Judit

11 Embryonic and adult stem cells for regenerative medicine II

Dr. Pongrácz Judit

12 Cell cycle and cancer therapy, p53 I

Dr. Pongrácz Judit

13 Cell cycle and cancer therapy, p53 II

Dr. Pongrácz Judit

14 Gene silencing technologies

Dr. Pongrácz Judit



130

Practices

Seminars


www.medbiotech.com

Participants



131

OPF-PRB PROTEIN BIOTECHNOLOGY






Topic

Biochemical properties of proteins. Protein synthesis. Review of the differences between procaryotic and eucaryotic protein synthesis.



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Biochemical properties of proteins. Protein synthesis. Review of the differences between procaryotic and eucaryotic protein synthesis.

Dr. Pongrácz Judit

2 Protein folding, the formation of 3D structure. Chaperons. Folding problems and folding diseases.

Dr. Pongrácz Judit

3 Protein sorting and targeting.

Dr. Pongrácz Judit

4 Study of protein structures: X-ray crystallography, NMR, mass spectrometry.

Dr. Pongrácz Judit

5 Protein purification (chromatography, electrophoresis) and analysis (SDS-PAGE, 2 dimensional electrophoresis, mass

spectrometry).

Dr. Pongrácz Judit

6 Posttranslational modification of proteins and their analysis using proteomics methods.

Dr. Pongrácz Judit

7 Protein-protein interactions and their analysis: yeast two hybrid system, mass spectrometry, Biacore and other techniques.

Dr. Pongrácz Judit

8 Heterologue expression I: Homologue and heterologue expression, biopharming; expression systems, criteria to the selection of

expression platforms, heterologue expression in Escherichia coli, formation of inclusion body, periplasmic secretion, formation of disulfide bonds.

Dr. Pongrácz Judit

9 Heterologue expression II: The disadvantages of the Escherichia coli system, development of new expression platforms; protein

expression in gram-positive bacteria; the Staphylococcus carnosus expression system; Protein expression in yeasts; the Saccharomyces cerevisiae and the Pichia pastoris expression platforms.

Dr. Pongrácz Judit

10 Heterologue expression III: The disadvantages of the microbial protein expression; heterologue expression in plant cell cultures,

transformation with Agrobacteria, expression in mammalian cell, functionalized cells; heterologue expression in insect cell lines, the baculovirus-insect cell expression system.

Dr. Pongrácz Judit

11 Definition of protein engineering; de novo design, artificial growing factors; rational design, site-directed mutagenesis; directed evolution, random mutagenesis, DNA shuffling, exon shuffling.

Dr. Pongrácz Judit



132

12 Production of human therapeutic proteins. Biopharmaceuticals, production of human therapeutic proteins; production of insulin,

protein engineering of insulin; development of recombinant Hepatitis B vaccine; production of monoclonal antibodies; problems with the storage, in vivo stability and administration of therapeutic proteins.

Dr. Pongrácz Judit

13 Production of human therapeutic enzymes: Enzymes in human therapy; production, and human therapeutically application of

deoxyribonuclease I, β-glucocerebrosidase, urate oxidase and L-asparaginase, mechanism of action.

Dr. Pongrácz Judit

14 Production of diagnostic enzymes. Importance of enzymes in diagnosis, production and application of glucose oxidase, galactose

oxidase, cholesterol oxidase and horseradish peroxidase; protein engineering of enzymes. The application of therapeutic proteins.

Possible administration, perspectives and future possibilities. The national and international requirements for protein therapeutic products.

Dr. Pongrácz Judit

Practices

Seminars


www.medbiotech.com

Participants



133

OPF-EXT EXTRACTION AND CHROMATOGRAPHIC TECHNIQUES IN MEDICINAL PLANT ANALYSIS

Course director: DR. TÍMEA BENCSIK, assistant professor




Course headcount limitations (min.-max.): 3 – 20 Prerequisites: OPA-MAN completed

Topic

With the increasing demand for herbal medicinal products, nutraceuticals, and natural products for health care all over the world,

medicinal plant extract manufacturers and essential oil producers have started using the most appropriate extraction and chromatographic

technologies in order to produce and standardize extracts and essential oils of defined quality. The aim of this course is to introduce the

most important extraction methods and chromatographic techniques used in the research of medicinal plants. Students should be able to

apply the acquired knowledge in their medical or pharmaceutical practice.

Task: To introduce state-of-the-art extraction techniques (maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound

extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression) and chromatographic analyses (column

chromatography, thin layer chromatography, high pressure liquid chromatography) of medicinal plants and their role in the production

of herbal medicines. Some applications, relating to different classes of substances, are presented to demonstrate the versatility of various

chromatographic techniques.

Requirements: students have to know the most frequent extraction and analytical techniques used in medicinal and aromatic plant research.



Mid-term exams

One written exam during the semester, the acceptance level is 60%.

One oral presentation by students.


There is no possibility to make up for missed lecture and practice.

Reading material



PowerPoint presentations prepared by lecturers.

- Notes


1. Handa S.S., Khanuja S.P.S., Longo G., Rakesh D.D.: Extraction Technologies for Medicinal and Aromatic Plants, International

Centre for Science and High Technology, Trieste, 2008

2. Reich E., Schibli A.: High-Performance Thin-Layer Chromatography for the Analysis of Medicinal Plants, Thieme, UK, 2007

3. Colegate S.M.: Bioactive Natural Products Detection Isolation and Structural Determination, CRC Press, 2008

4. Niessen W.M.A.: Liquid Chromatography - Mass Spectrometry, CRC Press, 2006

5. Nyiredy, Sz.: Planar Chromatography, Springer, Budapest, 2001.

6. Harris, DC.: Quantitative Chemical Analysis, WH. Freeman and Co., 7th edition, New York, 2007,

7. Schiedt K., Liaaen-Jensen S.: Isolation and Analysis, in Carotenoids Vol. 1A: Isolation and Analysis, Eds.: Britton G., Liaaen-Jensen S., Pfander H., Birkhäuser Verlag, Basel, 1995.

Lectures

1 Introduction of the course requirements. An Overview of Extraction Techniques for Medicinal and Aromatic Plants.

Dr. Horváth Györgyi

2 Introduction of state-of-the-art extraction techniques: maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression.


3 Introduction to Analytical Separations.


4 Techniques for the Purposes of Botanical Research.



134

5 Planar Chromatography: TLC.


6 Role of Different Procedures and Test Systems in the Knowledge of Herbal Substances.


7 Column Chromatography Systems: GC.


8 Column Chromatography Systems: HPLC.


9 Detectors Used in Different Separation Techniques and their Role in Qualitative and Quantitative Analysis.


10 Classification of Detectors Based on their Sensitivity and Selectivity.


11 Role of thin layer chromatography (TLC) in detecting microbiological processes: TLC-Bioautography.


12 Antimicrobial activity of essential oils using TLC-Bioautography.


13 Isolation and identification of carotenoids from medicinal plants.

Dr. Molnár Péter

14 Role of column liquid chromatography (CLC) in carotenoid research.

Dr. Molnár Péter

15 Extraction, separation and detection of carbohydrates from various plant samples, applying diverse chromatographic techniques.

Dr. Bencsik Tímea

16 Extraction, separation and detection of carbohydrates from various plant samples, applying diverse chromatographic techniques.

Dr. Bencsik Tímea

17 Identification of specific metabolites in herbal products. Adulterated dietary supplements.

Dr. Bencsik Tímea

18 Identification of specific metabolites in herbal products with TLC.

Dr. Bencsik Tímea

19 Isolation and Identification of flavonoids in medicinal plants.

Dr. Papp Nóra

20 Isolation and Identification of flavonoids in medicinal plants.

Dr. Papp Nóra

21 Comparative phytochemical studies on populations of medicinal plant taxa; their role in plant identification and in pharmacy.

Dr. Papp Nóra

22 Comparative phytochemical studies on populations of medicinal plant taxa; their role in plant identification and in pharmacy.

Dr. Papp Nóra

23 Student’s lecture.

Dr. Bencsik Tímea

24 Student’s lecture.


25 Written test.


26 Written test.


Practices

Seminars

1 Chromatographic seminar: GC.

2 Chromatographic seminar: HPLC.


The topics of the 1 written test are similar to the topics of the lectures.

Participants

Dr. Benkő András Antal (BEAQAAP.PTE)


135

OPF-MMG NUCLEAR MAGNETIC RESONANCE IN DRUG DEVELOPMENT

Course director: DR. ZOLTÁN BERENTE, associate professor




Course headcount limitations (min.-max.): 3 – 20 Prerequisites: OPA-BA2 parallel + OPA-MAN parallel

Topic

The course provides an insight into the process of drug development through examples that involve nuclear magnetic resonance as an

analytical tool. The method is extensively applied at numerous different points of the process, due to its versatility.

The course will discuss, after a brief theoretical introduction, the study of structure determination and structure-activity relationship of

drug candidate molecules. In the second phase the course will discuss some (mostly in vivo) applications used for the investigation of the efficacy of drug candidates in various animal models.



Mid-term exams

Presentation of a home project is required.


On the judgement of the course director.

Reading material



See Neptun Meet Street

- Notes

See Neptun Meet Street


R. A. de Graaf: In vivo NMR Spectroscopy, Wiley, 1998

N. Beckman: In vivo MR Techniques in Drug Discovery and Development, Taylor and Francis, 2006






Lectures

1 The NMR phenomenon, excitation and signal formation, relaxation

Dr. Berente Zoltán

2 Theory and practice of the Fourier-transform pulse NMR

Dr. Berente Zoltán

3 Basics of MR imaging

Dr. Berente Zoltán

4 MR methods in the drug development process

Dr. Berente Zoltán

5 Role of MR-based biomarkers in decision making during drug development

Dr. Berente Zoltán

6 Structure determination of small molecules using NMR

Dr. Berente Zoltán

7 Structure determination of biomolecules using NMR

Dr. Berente Zoltán

8 Structure-activity-relationships using NMR

Dr. Berente Zoltán

9 MR contrast agents

Dr. Berente Zoltán







136

10 MR studies of diabetes, obesity and inflammation models

Dr. Berente Zoltán

11 MR studies of stroke, MS and neurodegenerative disease models

Dr. Berente Zoltán

12 MR studies of preclinical tumor models

Dr. Berente Zoltán

13 MR studies of CV and lung disease models

Dr. Berente Zoltán

14 Project presentations

Dr. Berente Zoltán

Practices

Seminars


Participants


137

OPF-KIA ESSENTIAL OILS AND CLINICAL AROMATHERAPY





Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPG-FG1 completed + OPG-FG2 completed

Topic

Essential oils (EOs) are very interesting natural products and among other qualities they possess various biological properties. The term

biological comprises to all activities that these mixtures of volatile compounds (mainly mono- and sesquiterpenoids, phenylpropanoids,

etc.) exert on humans. EOs are used for their therapeutic action, for flavouring, in perfumery, or as starting materials for the synthesis of

other compounds. For therapeutic purposes they are administered as inhalations (e.g. eucalyptus oil), orally (e.g. peppermint oil) and

transdermally (e.g. rosmary oil). Oils with a high phenol content, for instance thyme and clove, have antiseptic properties, whereas others

are used as carrminatives. Oils showing antispasmodic activity, and much used in popular medicine, are those of melissa, peppermint,

chamomile, fennel, caraway and orange. Furthermore, in traditional medicine, EOs are also well-known for their analeptic, antimicrobial,

antinociceptive, antiphlogistic, antioxidative and sedative activities. All terpenoids easily enter the human body by oral absorption,

penetration through the skin, or inhalation very often leading to measurable blood concentrations. The aim of this course is to introduce

the most important medicinal plants containing essential oils and their medicinal role in the therapy and the clinical aromatherapy. We

would like to highlight their appropriate use, their profiles, but to call students’ attention to the cautions and contraindications of EOs, as well.



Mid-term exams

Two written exams during the semester, acceptance of them from 60%.



Reading material



PowerPoint presentations prepared by lecturers.

- Notes


1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London, New York, 2000

2. Tisserand R., Balacs T.: Essential Oil Safety: A Guide for Health Care Professionals, Churchill Livingstone, 1995

3. Tisserand R., Young R: Essential Oil Safety: A Guide for Health Care Professionals, Second edition, Churchill Livingstone, 2013

Baser C.H, Buchbauer G.: Handbook of Essential Oils. Science, Technology and Application. CRC Press, Boca Raton, 2010

Lectures

1 Introduction of the course requirements. Definition of aromatherapy and clinical aromatherapy.


2 Advantages and disadvantages of the application of essential oils.


3 History of the use of essential oils.


4 Biological activities of essential oils.


5 Sources of essential oils.


6 Chemistry of essential oils. Chemical composition of essential oils.



138

7 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas chromatographic analysis of essential oils.


8 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas chromatographic analysis of essential oils.


9 Drugs containing essential oils in the European Pharmacopoeia and in the ESCOP Monograph.


10 Quality of essential oils according to the official Pharmacopoeias.


11 External application of essential oils.


12 The most important base oils.


13 Physiological effects of essential oils. Metabolism of essential oil components in animal models and humans.


14 Contraindications.


15 Written test I


16 Written test I


17 Antimicrobial activity of essential oils. In vitro methods.


18 Antimicrobial activity of essential oils. In vivo methods.


19 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil, lavender oil.


20 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,

lavender oil.


21 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.


22 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.


23 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,

carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.


24 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil, carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.


25 Safety guidelines of essential oils.


26 Safety guidelines of essential oils.


27 Written test II


28 Written test II


Practices

Seminars


There is no list. The questions of the written test is similar to the lecture topics.

Participants


139

OPF-GTH GENE THERAPY

Course director: DR. GÉZA SÁFRÁNY, visiting professor

Institute of Laboratory Medicine




Topic

We wish to give a short overview about the present state of gene therapy, the current ongoing clinical trials and the potential side effects

of gene therapy and about the ethical considerations. The various viral and non-viral gene delivery protocols suitable for high efficiency

gene delivery both under in vitro and in vivo conditions will be discussed in details. Gene therapy protocols applied in the treatment of

malignant diseases will be presented together with the results of ongoing clinical trials. We will talk about the results and the potentials

of the treatments of inherited genetic disorders. One of the most promising field of the current clinical trials is the treatment of ischemic

diseases, the results will be presented. The potential applications of stem cells during gene therapy will be described, as well. Finally, we will discuss the side effects occurring during gene therapy and the ethical considerations will also be mentioned.



Mid-term exams


Joining later seminars, individual consultations.

Reading material


1. Kelly K. Hunt, Stephan A. Vorburger and Stephen G. Swisher (ed.): Gene Therapy for Cancer, 2007 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512

2. Thomas F. Kresina (ed.): Introduction to Molecular Medicine and Gene Therapy, 2001 by Wiley-Liss, Inc. ISBNs: 0-471-39188-3 (Hardback); 0-471-22387-5 (Electronic)


1. Sáfrány G.: A génterápia génsebészeti alapjai és jelenlegi helyzete, A Genom (ed.: Hídvégi EJ), Budapest, Széphalom Könyvműhely 2003, pp 187-204

2. Sáfrány G.: A vasculáris génterápia és a csontvelőőssejt-terápia, Atherosclerosis (ed.: Császár A.), Budapest, Synergo Kiadó, 2004 pp 336-344

- Notes


Lectures

1 Introduction to gene therapy, ongoing clinical trials

Dr. Sáfrány Géza

2 Gene delivery protocols, viral vectors applied in gene therapy

Dr. Sáfrány Géza

3 Targeted gene delivery and targeted gene expression

Dr. Miseta Attila

4 Gene therapy of HIV

Dr. Sáfrány Géza

5 Application of dendritic cells in gene therapy

Dr. Sáfrány Géza

6 Gene directed enzyme pro-drug therapy of malignant diseases

Dr. Sáfrány Géza

7 Immune therapy of malignant diseases

Dr. Sáfrány Géza

8 Radiation-driven gene therapy of malignant disease

Dr. Sáfrány Géza

9 Stem cells in gene therapy

Dr. Sáfrány Géza

10 Treatment of immune-deficiencies with gene therapy

Dr. Sáfrány Géza


140

11 Gene therapy of ischemic diseases

Dr. Sáfrány Géza

12 Gene therapy of cystic fibrosis

Dr. Miseta Attila

13 Gene therapy of thalassemia

Dr. Sáfrány Géza

14 Oncolytic viruses in tumor therapy

Dr. Sáfrány Géza

Practices

Seminars


Multiple choice tests for checking the acquisition of course material is given at the end of semester. Questions include material discussed in lectures and seminars.

Participants


141

OPF-IVF INFECTIONS AND IMMUNITY

Course director: DR. JÚLIA BARTHÓ-SZEKERES, professor

Department of Medical Biology



Course headcount limitations (min.-max.): 4 – 50 Prerequisites: OPO-MI1 completed + OPO-IMM completed

Topic

The importance of anti-infectious immunity is not restricted to elimination of pathogens, but is also responsible for long lasting protection,

as well as -in some cases- immunopathological disorders



Mid-term exams


Consultation

Reading material



Lecture slides

- Notes


1. H. Chapel, M. Haeney, N. Misbah, Snowden: Clinical Immunology, Blackwell, 2008

2. S. Kartikeyan, R.N. Bharmal, R.P. Tiwari, and P.S. Bisen: HIV and AIDS: Basic Elements and Priorities, 2007

3. T. Platts-Mills and Johannes Ring: Allergy in Practice, 2003

Lectures

1 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.

Dr. Barthóné Dr. Szekeres Júlia

2 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.


3 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.


4 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.


5 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.


6 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.


7 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.


8 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.


9 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.


10 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.


11 Evasion and use of the innate and adaptive immune responses by microorganisms.


12 Evasion and use of the innate and adaptive immune responses by microorganisms.


13 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation, sepsis, endotoxin shock, toxic shock syndrome.



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14 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation, sepsis, endotoxin shock, toxic shock syndrome.


15 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.


16 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.


17 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.


18 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.


19 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.








23 Immunopathological alterations following viral infections. The involvement of antibodies.


24 Immunopathological alterations following viral infections. The involvement of antibodies


25 Vaccination; Type of vaccines, requirements for vaccines.


26 Vaccination; Type of vaccines, requirements for vaccines.


27 Vaccination; rational vaccine development, mandatory vaccines.


28 Vaccination; rational vaccine development, mandatory vaccines.


Practices

Seminars


The same as lecture topics

Participants


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OPF-SUO EMERGENCY MEDICINE

Course director: DR. ZSÓFIA VERZÁR, associate professor

Department of Emergency Medicine



Course headcount limitations (min.-max.): 5 – 150 Prerequisites: OPO-KL1 completed

Topic

It is a basic requirement to initialize the aspect of proper emergency care for those who do not take part in emergency medicine. The aim

is getting closer to the purpose of care, decrease of avoidable death rates, prevention of organ failure, avoidance of disability, relief of suffering and pain.


Test exam.

Mid-term exams


Personal communication with the tutors.

Reading material


R. Aghababian: Essentials of Emergency Medicine, 2nd edition


- Notes


Lectures

1 Patient examination according to ABCDE

Dr. Gaál Ildikó

2 Resuscitacion

BLS, ALS, EPLS

Dr. Gaál Ildikó

3 Cardiovascular diseases

Dr. Verzár Zsófia

4 Cardiovascular diseases

Dr. Verzár Zsófia

5 Differential diagnosis of limb pain

Dr. Bóna Ernő

6 Pediatric emergency care

Dr. Bóna Ernő

7 Toxicology

Environmental diseases

Dr. Vígvári Szabolcs

8 Toxicology

Environmental diseases

Dr. Vígvári Szabolcs

9 Emergency care in neurology

Dr. Bóna Ernő

10 Acut psychiatric disorders

Dr. Bóna Ernő

11 Trauma care (ETC), Burns

Dr. Gaál Ildikó

12 Trauma care (ETC), Burns

Dr. Gaál Ildikó

13 Acute abdomen, Abdominal pain

Dr. Verzár Zsófia

14 Acute abdomen, Abdominal pain

Dr. Verzár Zsófia


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Practices

Seminars


Website of Emergency Medicine, University of Pécs.

Participants

STUDY PROGRAM 2016/2017 Elective and Optional subjects · UP FP Pharmacy major – Elective and...

Documents

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