SPECIFIC BODY DEFENSES: The Lymphatic and Immune System
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Transcript of SPECIFIC BODY DEFENSES: The Lymphatic and Immune System
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SPECIFIC SPECIFIC BODY BODY
DEFENSES: DEFENSES: The The
Lymphatic Lymphatic and and
Immune Immune SystemSystem
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A. FunctionsA. Functions 1. Absorption and return of
excess fluid the blood stream
2. Absorption of fat (in the villi of the small
intestine) 3. Immune System Function
I. Lymphatic SystemI. Lymphatic System
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B. Composed of B. Composed of 1. LymphLymph – interstitial fluid2. Lymph vesselsLymph vessels a. Closely associated with circulatory systemb. Similar to veinsc. Contraction of skeletal mscl causes movement of lymph fluid through valves
I. Lymphatic SystemI. Lymphatic System
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B. Composed of B. Composed of 3. Lymph OrgansLymph Organs
a.a. Lymph nodesLymph nodes » Areas of Concentrated
lymphocytes and macrophages along the lymphatic vessels
» Filter lymph
I. Lymphatic SystemI. Lymphatic System
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B. Composed of B. Composed of 3. Lymph OrgansLymph Organs
b.b. Bone MarrowBone Marrow produces
lymphocytesc. Spleen Spleen Serves as
Blood reservoirPurifies blood and lymph
I. Lymphatic SystemI. Lymphatic System
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B. Composed of B. Composed of 3. Lymph OrgansLymph Organs
c. Thymus causes pre-T cells to
mature to T-cells d. Tonsils e. Peyer’s Patches
I. Lymphatic SystemI. Lymphatic System
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A. Body’s 3 Lines of DefenseA. Body’s 3 Lines of Defense
1. SkinSkin
2.2. Mucous membranesMucous membranes
3.3. Immune systemImmune system
B. Immune System isImmune System is 1. Antigen specific 2. Systemic 3. Has memory
II. Immune ResponseII. Immune Response
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C. C. Kinds of Immune Response Kinds of Immune Response 1. Specific ImmunitySpecific Immunity
a. Antibodies bind only to antigen
b. B-lymphocytesB-lymphocytes – antibody prod.
c. T-lymphocytesT-lymphocytes – produce lymphokines
2. 2. Nonspecific DefenseNonspecific Defense a. Physical barriers b. Tears c. Phagocytesd. Fever / Inflammation
II. Immune ResponseII. Immune Response
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3. Humoral ImmunityHumoral Immunity a. Provided by antibodies in the
bodies fluids b. AntibodiesAntibodies
1) Are produced by lymphocytes
2) Circulate freely in the blood and lymph
3) Bind primarily to bacteria, toxins, free viruses
inactivates & marks for destruction
D. D. Kinds of Immune ResponseKinds of Immune Response
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4. Cell Mediated Immunity Cell Mediated Immunity a. Provided by nonantibody-producing lymphocytes b. Directly attack and lyse body cells.
1) containing viruses or parasite
2) Cancer cells3) Foreign grafts
c. Release chemical mediators 1) enhances inflammatory
resp.2) Help activate lymphocytes
or macrophages
D. D. Kinds of Immune ResponseKinds of Immune Response
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II. Immune ResponseII. Immune ResponseE. The Players
1. B-Cellsa.work chiefly
by secreting antibodies
b.Each B cell makes one specific
antibody
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II. Immune ResponseII. Immune ResponseE. The Players
1. B-Cellsc. When a B cell
encounters its triggering antigen it
gives rise to many large plasma cells that produce that specific antibody
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II. Immune ResponseII. Immune ResponseE. The Players
1. B-Cellsd. Antibody
structure 2 identical heavy chains and 2 identical
light chains shaped to form a Y.
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II. Immune ResponseII. Immune ResponseE. The Players
2. T-Cellsa.Function Some help
regulate the immune system
Others are cytotoxic (directly contact infected cells and destroy them
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II. Immune ResponseII. Immune ResponseE. The Players
2. T-Cellsb. Helper inducer
T cells
activate B cells and other T cells
c. Suppressor T cells
turn off or suppress immune cells
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II. Immune ResponseII. Immune ResponseE. The Players
2. T-Cellsd. Cytotoxic
T cells rid the body
of cells that have been infected by viruses as well and cancer cells
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II. Immune ResponseII. Immune ResponseE. The Players
4. Killer Cellsa. cytotoxic
T cells recognize
a specific antigen
b. Natural killer cellsdonot require a specific antigen
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II. Immune ResponseII. Immune ResponseE. The Players
3. Cytokines diverse and
potent chemical messengers secreted by the cells of the immune system Bind to specific receptors on target cells
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F. F. ImmunityImmunity
1. ImmunityImmunity – Whenever T cells and B
cells are activated, some become "memory" cells
– The next time that an individual encounters that same antigen, the immune system is primed to destroy it quickly
II. Immune ResponseII. Immune Response
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F. F. ImmunityImmunity
1. Active ImmunityActive Immunity achieved by responses of
ones immune system 2. Passive ImmunityPassive Immunity
achieved with exogenous immune cells or products
II. Immune ResponseII. Immune Response
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F. F. ImmunityImmunity
3. Passive Passive ImmunityImmunity
• achieved with exogenous immune cells or products
• Long term– Can be stimulated by infection also by vaccines
made from infectious agents that have been inactivated
II. Immune ResponseII. Immune Response
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F. F. ImmunityImmunity
3. PassivePassive• short term
– can be transferred passively
from one individual
to anothervia antibody-containing serumacross the placenta
II. Immune ResponseII. Immune Response
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FF. . Active, Passive and Active, Passive and Acquired Acquired Immunity Immunity
3. Acquired ImmunityAcquired Immunitycomes from infection or from a new born’s mothe
4. Artificial Immunity Artificial Immunity comes from immunizations
II. Immune ResponseII. Immune Response
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GG. . Autoimmune diseases Autoimmune diseases
1. diseases caused by failure of the immune system to recognize “self 2.2. Examples
a. rheumatoid arthritisrheumatoid arthritis (joints)b. lupus erythematosuslupus erythematosus
(connective tissue)c. GravesGraves’’ disease disease (thyroid)
II. Immune ResponseII. Immune Response
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GG. . AIDS - Immunodeficiency AIDS - Immunodeficiency Syndrome Syndrome
1. Causes death 2. Caused by Human
Immunodeficiency Virus (HIV)3. kills T-4 lymphocytes
4. T-4 lymphocytes induce B-lymphocytes to fight infection
5. Debilitated immune system
II. Immune ResponseII. Immune Response
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GG. . AIDS - Immunodeficiency AIDS - Immunodeficiency Syndrome Syndrome
6. no cure for HIV
7. HIV infection causes AIDS, and AIDS allows other infections to kill the
person with the HIV infection
II. Immune ResponseII. Immune Response