12 Lesson 12.1: The Lymphatic System Lesson 12.2: Nonspecific Defenses Lesson 12.3: Specific...
-
Upload
christiana-horn -
Category
Documents
-
view
255 -
download
0
Transcript of 12 Lesson 12.1: The Lymphatic System Lesson 12.2: Nonspecific Defenses Lesson 12.3: Specific...
12
Lesson 12.1: The Lymphatic System
Lesson 12.2: Nonspecific Defenses
Lesson 12.3: Specific Defenses
Lesson 12.4: Disorders and Diseases of the Immune System
The Lymphatic and Immune Systems
Lesson 12.1
The Lymphatic System
Chapter 12: The Lymphatic and Immune Systems
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• organization of the lymphatic system– lymph formation and flow– lymph drainage
• lymphatic cells, tissues, and organs– lymphatic cells– lymphatic tissues– lymphatic organs
The Lymphatic System
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Organization of the Lymphatic System
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• fluid leaks out of blood vessel capillaries– about 4 liters per day
• enters lymphatic capillaries
• fluid is now called lymph
• returns to circulatory system through lymphatic trunks
Lymph Formation and Flow
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• thoracic duct– drains legs, abdominopelvic
area, left arm, and left side of the head and thorax
• right lymphatic duct– drains right arm, right side
of head, and right side of the thorax
Lymph Drainage
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Lymph Drainage
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• lymphocytes– T lymphocytes mature in thymus– B lymphocytes mature in bone marrow
• macrophages– begin as monocytes– leave lymphatic tissue to enter surrounding tissue
Lymphatic Cells
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• mucosa-associated lymphatic tissue– tonsils
• pharyngeal• palatine• lingual
• lymphatic nodules
Lymphatic Tissues
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• lymph nodes– cleanse lymph– store and produce T and B cells
Lymphatic Organs
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• spleen– scans and cleans blood
• thymus– nursery for T cells
Lymphatic Organs
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Match these words with 1–4 below: right lymphatic duct, thoracic duct, tonsil, spleen.
1. drains left side of head
2. scan and clean blood
3. drains right side of head
4. palatine
Review and Assessment
Lesson 12.2
Nonspecific Defenses
Chapter 12: The Lymphatic and Immune Systems
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• physical barriers• cellular and chemical defenses• inflammatory response• fever
Nonspecific Defenses
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• skin• hair• acidic secretions from sebaceous glands and
sweat glands• mucous membranes
Physical Barriers
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• phagocytosis– engulf foreign cells and debris– neutrophils– macrophages (formerly monocytes)– exocytosis
• natural killer cells– release perforins to perforate cells
Cellular and Chemical Defenses
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• complement system– classical pathway– alternative pathway
• opsonization
• interferons– released by virus infected cells– alpha, beta, gamma interferons
Cellular and Chemical Defenses
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
The Complement System
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• promotes repair of damaged tissue• histamines and prostaglandins released• symptoms
– heat– redness– swelling– pain
Inflammatory Response
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• tissue damage occurs• intracellular contents are released from damaged
cells into interstitial fluid• mast cells release histamine and other
inflammatory chemicals• blood vessels dilate, blood flow increases,
capillary permeability increases• clot formation occurs• scar tissue forms, replacement cells grow
The Development of Inflammation
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• maintenance of higher than normal body temperature
• activation of leukocytes and macrophages causes release of pyrogens
• hypothalamus raises body temperature, causing a fever
Fever
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
True or False?
1. Interferon is released by virus infected cells.
2. Pyrogens cause fever.
3. Neutrophils are not phagocytes.
4. Mucous membranes are a physical barrier.
5. Perforins engulf cells.
Review and Assessment
Lesson 12.3
Specific Defenses
Chapter 12: The Lymphatic and Immune Systems
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• antigens• immune system cells• humoral immunity• primary and secondary immune responses• cellular immunity
Specific Defenses
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• on the surface of cells– proteins– polysaccharides– glycolipids– nucleic acids
• determine “self” from “nonself” cells
Antigens
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• lymphocytes– recognize only one antigen– clonal selection– memory cells
• MHC proteins– class I– class II
Immune System Cells
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• antibody-mediated immunity• plasma cells
– antibodies recognize and bind to specific antigen
• antibodies– also called immunoglobulins– recognize, bind to, and mark antigens– interfere with antigen function
Humoral Immunity
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Antibody Classes
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• primary immune response– when first exposed
• secondary immune response– memory cells respond to invader
• active immunity• passive immunity
– vaccination
Primary and Secondary Immune Responses
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Cellular Immunity
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Fill in the blanks with: antibodies, antigen, memory cells, or vaccination.
1. A(n) _______________ is passive immunity.
2. _______________ are also called immunoglobulins.
3. Lymphocytes recognize only one _______________.
4. _______________ are part of the secondary immune response.
Review and Assessment
Lesson 12.4
Disorders and Diseases of the Immune System
Chapter 12: The Lymphatic and Immune Systems
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• cancer and lymph nodes• allergies• autoimmune disorders• HIV and AIDS
Disorders and Diseases of the Immune System
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• rapid, unregulated cell growth• metastasis
– cancerous cells move within body
• cancerous cells may lodge in lymph nodes
Cancer and Lymph Nodes
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• inappropriately strong response to a harmless environmental antigen
• exposure to allergen causes release of histamine• histamine causes allergy symptoms
– runny nose, itchy eyes, anaphylaxis
• anaphylaxis• immunotherapy
Allergies
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Allergies
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• immune system attacks own body• cause unclear• examples
– rheumatoid arthritis– multiple sclerosis– type I diabetes
Autoimmune Disorders
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
• HIV – infects and kills helper T cells
• AIDS – helper T cell count falls below 200/mm3– immune system seriously weakened– patient is susceptible to opportunistic infection
HIV and AIDS
Permission granted to reproduce for educational use only.© Goodheart-Willcox Co., Inc.
Match these words with 1–4 below: metastasis, autoimmune disorder, HIV, cancer.
1. rapid, unregulated cell growth
2. cancerous cells move within the body
3. rheumatoid arthritis
4. infects and kills T cells
Review and Assessment