Skeyndor global lift treatment

The first global face lift* range to restore the

youthful facial contours

OVAL SHAPE · NECK · CHEEKBONES -

Technical Development

2

Mature skin Photoaged mature skin

SEM575, Courage & Khazaka

3

Skin firmness vs age

Men

Women

Age range (years)

M

od

era

te o

r se

ve

re e

last

osi

s (%

)

-4%

-8%

1SILAB data base

-8%

2 Panel: 19vol. 59±7 with mature skin vs 19vol. 59±10 with photoaged mature skin.

Age range2 Age range1

Real (Cutometry)

Perceived (Medic. Eval.)

50-59 (healthy) 50-59 (photoaged)

Re

al F

irm

ess

(c

uto

me

try %

)

Firm

ess

(c

uto

me

try %

)

Overrest.

Up to the age of 50, loss is slight and progressive. From the age of 50s this

loss increases due to loss of firmness and elasticity.

The sun has a notable effect on the loss of firmness and ages the skin by 10

years.

There is no correlation between the loss of real firmness and the visual

symptoms of sagging skin (perceived firmness).

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Skin firmness vs age

Mature skin Photoaged mature skin

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Epi

derm

is

Pap

illar

y

Der

mis

Ret

icul

ar

Der

mis

Reticular dermis= Dense tissue

Funct. Comp.: Collagen and elastin

Resistance, support

Extrinsic aging (UV)

Deep wrinkles, loose skin

Skin histology. Function

Papillary dermis = Connective tissue

Funct. Comp.: Collagen and elastin

Elasticity, deformability

Intrinsic aging (R.L) and extrinsic aging

(UV)

Median wrinkles, lack of elasticity.

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Pro-collagen

Anti-photoageing

Anti-age

Papillary dermis

(Intrincis ageing)

Reticular dermis

(Extrinsec ageing)

Anti-elastase

The cosmetic face lift of the future

The cosmetic face lift of the future

Components:

1. Active substances that stimulate the synthesis of the basic dermal

elements

1. To stimulate the collagen production

2. To protect the elastin from its degeneration.

2. Active substances that reverse photoaging in the profound dermis

(permitting the recovery of 10 years of youth).

3. Next-generation anti-age components that reverse the general aging of

the skin.

Pro-youth strategies 7

Aging

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Determinado por factores de estrés (Rayos UV, Factores genéticos, Radicales

libres, fallos en el ADN, etc.).

Se refiere al estado de salud de

nuestras células, es decir cuando la

apariencia no corresponde a la

edad cronológica.

Determinado por la edad.

Esta evolución de la piel no

puede evitarse, es decir el ciclo

normal de la vida:

Nacer, Crecer, Envejecer ...

CHRONOLOGICAL “Real Age”

BIOLOGICAL· SENESCENCE “Apparent Age”

Determined by age. This dermal

process cannot be avoided,

and is part of the normal life

cycle: being born, growing up

and aging …

Determined by stress factors (UV

radiation, genetic factors, free

radicals, DNA failures, etc.) This refers

to the state of health of our cells, i.e.,

when one’s appearance does not

match one’s chronological age.

Aging

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10

20

30

40

50

60

70

90

80

10 20 30 40 50 60 70 80 90 REAL AGE

APPA

REN

T A

GE

BIO

LOIC

AL

AG

EIN

G

CHRONOLOGICAL AGEING

IDEAL CONDITIONS

PRO-YOUTH STRATEGIES

EXTRINSIC FACTORS Sun, Stress, Tabaco, Free radicals

Telomerase agents

They artificially lengthen the life expectancy of adult cells

(new and old).

Stem cells

They promote the generation of new cells from stem cells. (cosmet. It is applicable to tissues that already contain them).

Anti-senescence marker therapies They reverse aging in old cells and delay aging in young

ones.

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Pro-youth strategies

Their size and shape is different

- reduction in their functional capacity, which is responsible for the signs of age.

- they have lost their capacity to replicate themselves or divide.

+ greater resistance to mutation processes (neoplasias) or cell death.

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Adult cell

Senescent cell

“The phase when adult

cells evolve to a senescent

stage”

Senescence

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“A molecule/structure present in

all senescent cells.”

The marker that is currently giving promising results in combating

age is PROGERIN.

PROGERIN is an alteration of the protein laminA and it plays a part in the premature aging disease, Progeria or Hutchinson-Gilford Syndrome.

Senescence markers

Lamin A is a protein responsible for maintaining

the cell nucleus structure. It degenerates with

time and is converted into progerin, a toxic,

disfunctional protein that produces

malformations in the nucleus structure.

With respect to cells this leads to an alteration in

their functioning, which is reduced to a state of

low-functionality or senescence.

With respect to skin it leads to the dreaded

signs of age (apparent or biological age).

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Senescence markers

Progerin.

The concentration of progerin gives us an idea of the biological

age(health) of the cells.

Nuclear membrane

Lamin A

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Morphological differences in the nuclear membrane in young and senescent cells

Cell nucleus from a donor aged 9

Cell nucleus from a donor aged 96

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Morphological differences of the nuclear membrane in healthy cells and Hutchinson–Gilford Syndrome cells

Cell nucleus from a young healthy donor

Cell nucleus from a donor with Hutchinson–Gilford

Syndrome

In the skin, progerin is present in the skin in fibroblasts and keratinocytes

It is estimated that progerin accumulates at a rate of 3% per year and

increases with age (from the age of 55).

starting with the papillary dermis and

gradually spreading to the reticular

dermis.

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Progerin and skin

GLOBAL LIFT [ProGEN-in] is an exclusive technology developed

by SKEYNDOR® that is based on anti-senescence marker

therapies.

A global anti-age strategy designed to achieve a facial

redefining effect, which restores the fullness of the jaw line and

attenuates submental fat in mature skin.

It is targeted at: progerin, a cell aging marker which makes it

possible to estimate the biological age of the cells.

The ultimate objective: to improve the functioning of cells with a

slow metabolism, which results in a loss of thickness, firmness and

resilience in the tissues, found in mature and/or photoaged skin.

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[ProGEN-in] TECHNOLOGY IS BASED ON THE EFFECTS OF THREE SPECIFIC

ACTIVE SUBSTANCES:

-Biomimetic peptide derived from Elafin, winner of the

Innovation Zone Best Ingredient Award 2012 at In-cosmetics®,

Barcelona 2012. An enzymatic inhibitor with anti-progerin and

anti-elastase activity that combats flaccidity in mature skin.

-Menyanthes trifoliata extract, a potent next-generation antioxidant that protects the cellular Vitamin C content, a key

cofactor in improving the quality and quantity of collagen in the

skin.

- α-glucans and black pepper (Piper nigrum)

rhamnogalacturonans. Molecules that act on the profound

dermis –reticular dermis- and improves the skin’s mechanical

properties (supportive), particularly in prematurely photoaged

skin.

[ProGEN-in]

TECHNOLOGY

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Papillary dermis

(Intrincis ageing)

Reticular dermis

(Extrinsec ageing)

Menyanthes trifoliata ext.

Pro-collagen

Black pepper extract

Reticular anti-photoageing

Peptide biomim. elafin

Anti-progerin

Anti-elastase

[ProGEN-in]

TECHNOLOGY

Scientific evidence

20 1Alaria algae extract

+262%

+44%

0%

66 years

35 years

IN VITRO TEST ON THE PRODUCTION OF PROGERIN IN

HUMAN KERATINOCYTES1

Pro

ge

rin

(p

p/u

g p

rote

ins)

Control Algae ext. 0.1 Algae ext. 1.0

Dose

The marker levels are

reduced in mature cells (66

years) to the levels of cells

that are 30 years younger

[ProGEN-in]

TECHNOLOGY

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In-vitro test. Anto-progerin effect on the

functionality of mature human keratinocytes*

High recovery of general cellular functionality (ribosomes, mitochondria

and proteosomes)

[ProGEN-in]

TECHNOLOGY

*Alaria Algae extract.

In-vitro test. Effect on the functionality

of photoaged human reticular

fibroblasts*

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Non irradiated control

Adhesion:+++ (100%)

Contraction:+++ (100%)

Migration: +++ (100%)

Irradiated UVA control

Adhesion:+ (65%)

Contraction : + (32%)

Migration : ++ (75%)

UVA + Piper Nigrum ext.

Adhesion:++ (83%)

Contraction :++ (83%)

Migration : +++ (94%)

*α-glucans and black pepper (Piper nigrum) rhamnogalacturonans.

Recover of the reticular cells funcionality on photoaged skins.

[ProGEN-in]

TECHNOLOGY

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[ProGEN-in]

TECHNOLOGY Clinical study. In-vivo Fringe

Projection

Equipo de proyección de franjas Proyección de franjas sobre zona a evaluar

Digitalización de imagen y cálculo de aéreas 23

Fringe projection equipment Fringe projection in area to be evaluated

Image digitalisation and calculation of regions

1Biomimetic peptide. 24

• Placebo •Péptido biomimético de la Elafina 2%

[ProGEN-in]

TECHNOLOGY Clinical study. In-vivo Fringe

Projection Technique1

•Placebo

•Biomimetic peptide

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After 28 days there is a significant reduction

(up to -18%) in the facial contour

-18%

Clinical study.

SAGGING of jaw line2

2 Menyanthes Ext. 25

[ProGEN-in]

TECHNOLOGY

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After 28 days there is a significant reduction

(up to -18%) in jowls

-18%

Clinical study.

SAGGING of jaw line2

[ProGEN-in]

TECHNOLOGY

2 Menyanthes Ext.

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After 28 days there is a significant reduction in wrinkles due to sagging

Clinical study.

Wrinkles caused by sagging1


[ProGEN-in]

TECHNOLOGY

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After 28 and 56 days there is a slight to moderate reduction in facial

ptosis

FACIAL ptosis: observation of the number and depth of skin folds in the ear surrounding the

ear when the patient is lying down.

Clinical study.

Anti-gravity effect1


[ProGEN-in]

TECHNOLOGY

Global Lift.

Clinical study subject

to medical control

A specialist evaluated 20 volunteers aged between 50 and 69, and determined their Mean

Sagging Skin Index (MSSI) before and after treatment with Global Lift*, based on:

All the volunteers had slight to moderate sagging of the face, cheeks and neck: 1 to 3.5 on a scale of 0

(without) to 4 (very significant).

The improvement in firmness was assessed objectively with the non-parametric Wilcoxon Exact Test

comparing the results of D0 and D28.

Empirical formula

IFM= (Sum of score obtained for

cheeks/jaw line and neck) / 2

0 = IFM No sagging

0 < IFM ≤ 1 Slight

1 < IFM ≤ 2 Moderate

2 < IFM ≤ 3 Significant

3 < IFM ≤ 4 Very significant

and the table

Sagging tissue scale. 0-Firm skin (terse, perfect adapted to muscle, immediate return)

1-Slight sagging (terse, small wrinkles when pressed, immediate return)

2- Moderate sagging (small wrinkles, median when pressed, slow but complete

return).

3-Sagging skin (wrinkles without pressing, partial detachment of muscle, slow and

incomplete return).

4-Extremely loose skin (large wrinkles, total detachment of muscle, no return).

*In-use test: 20 volunteers Treatment: Antigravity Lifting Programme (4 sessions)

+Redefining cream + Redefining eye contour cream 29

FIRMING EFFECT

MEAN SAGGING SKIN INDEX (MSSI)

Volunteers D0 D28

D28-D0

Reactive

volunteers Ref. Surname/name

Face Neck Face Neck

1 MI/ES 3 3 3 2 3 2,5 -0.5 +

2 PE/LU 2 3 2,5 2 3 2,5 0 -

3 CO/CA 1 1 1 0 1 0,5 -0.5 +

4 CO/AN 1 2 1,5 1 2 1,5 0 -

5 BR/ME 1 1 1 0 1 0,5 -0.5 +

6 TO/MO 2 3 2,5 1 2 1,5 -1 +

7 RO/AN 2 2 2 1 2 1,5 -0.5 +

8 PE/MD 2 3 2,5 1 3 2 -0.5 +

9 JA/MA 1 1 1 0 0 0 -1 +

10 VI/NU 3 4 3,5 2 4 3 -0.5 +

11 MO/MA 1 2 1,5 0 1 0,5 -1 +

12 MU/MA 2 3 2,5 2 3 2,5 0 -

13 GA/RO 1 2 1,5 0 1 0,5 -1 +

14 PE/IS 2 3 2,5 2 3 2,5 0 -

15 MI/VI 2 3 2,5 1 3 2 -0.5 +

16 PE/IR 3 3 3 3 3 3 0 -

17 MO/AN 1 1 1 0 1 0,5 -0.5 +

18 CO/MA 1 1 1 0 1 0,5 -0.5 +

19 MI/EL 1 2 1,5 0 2 1 -0.5 +

20 PE/MP 3 4 3,5 3 4 3,5 0 -

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Global Lift.


to medical control


+Redefining cream + Redefining eye contour cream

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“After 28 days of treatment, there is a reduction in the Mean Sagging

Skin Index (MSSI) of 12.5% in the whole panel and 15% in the quartile

of most reactive volunteers (70%), which is statistically significant

(p<0.001).”

It is concluded that thanks to the Global Lift*

treatment, the skin is rejuvenated by 5 to 6 years on average in terms of apparent sagging.

Global Lift.


to medical control.

Results



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Global Lift.

Self-evaluation.

Results.



Younger skin’s appearance

Jowls smoothed

Global firming effect

Restores facial fullness

Attenuation of flaccidity folds/wrinkles

Cosmetic lfiting effect

Smoothed eye contour (circles-puffiness)

Percentage of positive opinions

Based on anti-age clinical studies that have been revised.

Skin flaws in women from a certain age. Association with

hormonal deficits.

Does not take into account the firming/lifting effect combined

with global aging.

At present soya and their derivatives are associated with mid

value lines.

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Global Lift vs. Platinum Platinum is focused at:

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Salon treatment

ANTI-GRAVITY LIFTING

PROGRAMME

RESTORES FULLNESS TO THE FACE

AND NECK

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Activating Firming Gel

An emollient non-oily gel that

facilitates facial massage in

the salon. With tensor and

firming properties.

Active substances:

Menyanthes trifoliata, Clhorella Vulgaris, Probiotic

Lysate, Amino Acidos.

Anti-gravity Serum

A serum formulated for

producting a global lifting effect on the skin. Specially

developed for treating loose,

mature and prematurely

photoaged skin. With

hydrolysed collagent and

organic silicon which consolidate the skin’s

suppoprtive properties.

Active substances: Biomimetic

peptide derived from Elafin, Black Pepper, Collagen,

Organic Silicon.

Immediate Lift Action Mask

A lifting-effect Mask for the face

and neck, with a wrinkle-ironing

effect. Its patch-like format gives

spectacular and immediate

firming results, with great

professionalism and

effectiveness.

Active substances: Yeast cell

lysate, Asian Centella, Aloe Vera.

Lift Contour Cream

A face and neck cream

based on [ProGEN-in] anti-

age technology. An

advanced cosmetic for a

global firming effect that

restores fullness to the face.

Active substances: [ProGEN-in]

Tech., Algae Ext., Lupin Ext.

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Home treatment

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Lift Contour Face and Neck Cream Firming· Redefining · Anti-wrinkle Treatment

Effects:

• Firms the skin and reduces wrinkles.

• Cosmetic lifting effect.

• Restores the fullness of a youthful face.

Active substances:

• [ProGEN-in] technology.

• Alaria algae extract.

• Lupin extract.

Presented in two different textures, depending on the skin type:

• Dry skins: with a rich, creamy texture.

• Normal to combination skins: with a lighter, non-oily texture.

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Lift Definition Eye Contour Cream Triple orbicular effect, [ProGEN-in] technology

Effects:

• Firms the skin and reduces wrinkles.

• Attenuates eye bags.

• Relieves congestion in eyelids and eye bags.

Active substances:

• [ProGEN-in] technology.

• Alaris algae extract.

• Buckwheat.

• Firming anti-wrinkle lipopeptide.

Sales argument

Key points

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Main sales arguments for differentiation

Global Lift Eternal Corrective

Recommended age

50s

From 35

40s

From 35

From 40

Skin type

Mature skin with loss of firmness

and wrinkled due to sagging.

Photoaged skin.

Globally aged skin Mature skin with deep

wrinkles and expression lines

Final consumer profile

Women who want to rejuvenate

their faces and attenuate

wrinkles caused by sagging.

Women on high-protein diets.

Women who want to recover

a globally younger face

(radiance, wrinkles, sagging,

moisturising, nutrition, etc.).

Women who do not want

minimally invasive surgery.

Maintenance after injecting

hyaluronic acid and botox.

Active substances

Exclusive [ProGEN-in] technology Liposome stem cells of plant

origin

Botox-like peptides, snake

venom and hyaluronic accid

filler

Benefit

Restores the facial fullness of

youth.

Better defined contours in JAW

LINE · NECK · CHEEKBONES

Restores a globally more

youthful face

The result is face with fewer

wrinkles, more fullness and

terser skin

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Thank you for

your attention

Skeyndor global lift treatment

Education

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