WHY DO WE AGE?

Various factors:

EXTERNALINTERNAL

40% 60%

CAUSES OF AGEING

BIOLOGICAL ENVIRONMENTAL

GeneticHormonal

Sun, PollutionTobacco smoke

CAUSES OF AGEING

RESULTS OF AGEING

COSMETIC RESPONSE

REGENERATION REPAIR CORRECTION

REGENERATION

REPAIR

CORRECTION

SKEYNDOR PROPOSE

REGENERATION

SKEYNDOR PROPOSE

CORRECTIONREPAIR

eternal line

All the cells in the same organism:

Have the same genetic system, DNA. (instruction manual )

Are differentiated. (specialised for one specific function and place)

Have a limited capacity to multiply themselves.(btw 30 and 50 copies)

The copies have exactly the same characteristics as the original. (specialisation and age)

Stem cellsCan multiply themselves

an endless number of times.

They produce new daughter cells

without any record of age or damage.

Uttwiler Spätlauber

YOUNG AGED

The secret of its longevity

Studies of the epigenetic factors of the stem cells extracted from the Spätlauber reveal the tremendous regenerative capacity of this apple variety.

This regenerative capacity could pass on to the fruits, giving them the secret of withstanding the passage of time.

Eternal line

Active ingredient : stem cells

(of plant origin)

Proven efficiency in the treatment of epidermal

stem cells and in dermal fibroblasts.

Active ingredient acknowledged by the 2008 Innovation Award (European Cosmetic Academy).

LUPIN EXTRACT

Redensifies the dermis and increases the synthesis of high quality collagen.

OIL SOLUBLE JAMBU EXTRACT

Reinforces the biomechanical functions of the dermis and reorganises the collagen.

OIL SOLUBLE SEA FENNEL

EXTRACT

OIL SOLUBLE MARINE

LAVENDER EXTRACT

HYALURONIC ACID +

ORGANIC SILICON

Strong free radical action Relaxes muscular

contractions –BOTOX effect

Increase significantly the synthesis of high quality collagen.

SummaryProduct source Malus domesticus var. Uttwiler Spätlauber

PhytoCellTec to produce apple stem cells

Maintenance and protection of skin stem cells

Results show: - protection of stem cells against UV-irradiation

- growth promotion of stem cells

- increase of life span of hair follicle stem cells

- reduction of skin wrinkles

Eternal Cream

Cream with plant origin stem cell nanoliposomes. Formulated to compensate the loss of the vital substrate and to restore the skin’s volume lost with age at the deepest levels. The face appears fuller, smoother and firmer.

EternalIntensive serum

Eternalbody repair serumFor areas of thin skin. For instanceunder the arms inner thighs, thecleavage area.

Eternalicy eye cream

Eternal professional pack

Eternal to emphasize…

Produced through development in co-operation of state-of-the-art Swiss technology.

Extract of a Swiss plant species (apple)

Developed with nanotechnology

Air-less packagings that prevent the proliferation of bacteria and conserve the active ingredients

Enriched with active ingredients that are effective throughout the three layers of the skin.

Two textures for all skin types.

”Always beautiful, forever young”

THE INVESTIGATION

It has taken 3 years research, more than 25

tested substances and a study of about 200

combinations for the SKEYNDOR

Laboratories to create CORRECTIVE.

CORRECTIVE LINE

AGENTS NEURAL-INHIBITORS

LAVANDULA STOECHAS

ACMELLA OLERACEA

PRE SYNAPTIC PEPTIDES

ACETYL HEXAPEPTIDE-8 or “botuline-like”

PENTAPEPTIDE-18

x x

POST-SYNAPTIC PEPTIDES

VIPER'S VENOM

ACETYL HEXAPEPTIDE-30,

• Cosmetic

HYALURONIC ACID

SKIN FILLING SUBSTANCES

CORRECTIVE ACTIVES

Dried spheres Swallow spheres

MECHANISM:Penetrate and swallow into the skin

Cosmetic HYALURONIC ACID

MAIN ACTIVE INGREDIENTS

• Internal tissue redensifiers

• Skin filling substances

• Neural-inhibitor agents

• Skin-lifting peptides with pre- synapticactivity.

• Skin-lifting peptides with post-synapticactivity. The ultimate concept in anti-ageing.

CORRECTIVE ACTIVES

MAIN ACTIVE INGREDIENTSSkin filling substances

Neural-inhibitor agents

Internal tissue redensifiers

Skin-lifting peptides

CORRECTIVE ACTIVES

Skin-lifting peptides

Skin filling substances

Neural-inhibitor agents

Internal tissueredensifiers

Biological solution with muscle-relaxing peptides

Solution based on muscle-relaxing peptides with complementary

action, that creates a more intense and longer-lasting skin-lifting

action.

Dosage discs + Fill-in Hyaluronic

Lyophylized matrix of polysaccharides that intensifies the attachment

and absorption of active ingredients in the skin. Together with the

concentrated hyaluronic acid solution with fill-in effect.

Pearl based regenerating mask

Micronised pearl mask. With nutritive, softening, depigmentating

action that improves the skin's resistance, by delaying the

appearance of wrinkles and other signs of ageing.

CORRECTIVE TREATMENT FOR WRINKLES AND EXPRESSION LINES

Expression Lines Serum

Facial serum for treating expression lines and wrinkles. It combines muscle relaxing

active ingredients with fill-in substances.

Instant Wrinkle Filler Cream

Facial cream for filling wrinkles and expression lines. It combines skin fill-in

substances containing active ingredients with muscle relaxing properties.

Eye Expression Lines Eraser

Anti-wrinkle treatment cream with fill-in effect for eye contour.

Instant Lip Contour Filler

Lip contour cream with fill-in substances and muscle relaxing active ingredients, for

softening wrinkles around the lips.

Wrinkle analysis: Quantirides® Technique:

Female Volunteer 1, before and after treatment

D28D0

3) Fotografías Voluntaria 1

Patas de gallo

Entrecejo

D0

D0

D28

D28

IN VIVO EFFICACY: CLINICAL RESULTS

3) Pictures Booth Treatment (1session)

IN VIVO EFFICACY: CLINICAL RESULTS

3) Pictures Booth Treatment (1session)

IN VIVO EFFICACY: CLINICAL RESULTS

3) Pictures Booth Treatment (1session)

IN VIVO EFFICACY: CLINICAL RESULTS

3) Pictures Booth Treatment (1session)

IN VIVO EFFICACY: CLINICAL RESULTS

Cell...

Specific stress-related factors (UV

radiation, genetic factors, free radicals,

DNA errors...)

It refers to the state of health of our cells, i.e., when one’s appearance is not in keeping with one’s chronological age.

Determined by age.

This evolution of the skin is unstoppable, and forms part of the normal cycle of life.

CHRONOLOGICAL BIOLOGICAL or SENESCENT

A senescent cell is one which...

- has lost its capacity to replicate itself or divide.

- is resistant to the processes of mutation or cell death.

- acts like a retired cell with reduced functional capacity and appears to be old

Lamin A is is converted into progerin, a

toxic, protein that produces malformations

in the membrane of the nucleus.

When the membrane of the nucleus

deformed-

The cells are reduced to a state of low-

functionality or senescence.

With respect to skin it leads to the dreaded

signs of age (apparent or biological age).57

Senescence markers

Progerin.

Senescence markers

Chromosomatic aging

Intrinsic TELOMERE EROSION

Extrinsic DAMAGE TO THE DNA

Epi

derm

isP

apill

ary

Der

mis

Ret

icul

ar

Der

mis

Papillary Dermis = Connective tissue

Func. Comp.: Collagen and elastin

Resilience, elasticity, deformability

Intrinsic aging (L.R.) and extrinsic aging (UV)

Median wrinkles, loss of elasticity.

Reticular Dermis= Dense tissue

Func. Comp.: Collagen and elastin

Resistance, support

Extrinsic aging (UV)

Deep wrinkles, loose skin

Skin histology. Function

The cosmetic face lift of the future

Components:

1. Active substances that stimulate the synthesis of

1. Collagen production

2. To protect the elastin from its degeneration.

2. Agents that reverse photoaging in the profound dermis (permitting the

recovery of 10 years of youth).

3. Next-generation anti-age components that reverse the general aging of

the cells

Global lift based on pro youth sratagies61

Aging

64

10

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70

90

80

10 20 30 40 50 60 70 80 90 REAL AGE

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CHRONOLOGICAL AGEING

IDEAL CONDITIONS

PRO-YOUTH STRATEGIES

EXTRINSIC FACTORSSuffacn, Stress, Tabaco, Free radicals

EXTERNAL FACTORS

THE [PROGEN-IN] TECHNOLOGY IS BASED ON THE EFFECTS OF THREE

SPECIFIC ACTIVE SUBSTANCES:

-A biomimetic peptide derived from Elafin, winner of the Innovation

Zone Best Ingredient Award 2012 at In-cosmetics®, Barcelona 2012. This

is an enyzymatic inhibitor with an anti-progerin and anti-elastase effect that

combats flaccid tissue in mature skin.

-Menyanthes trifoliata extract, a potent next-generation antioxidant that

protects cellular vitamin C content, an essential cofactor in improving the

quality and quantity of collagen in the skin.

- α-glucans and Black Pepper (Piper nigrum) rhamnogalacturonans.

These molecules act on the profound dermis (reticular dermis) to improve

the skin’s mechanical properties (supportive), particularly in prematurely

photo-aged skin.

[ProGEN-in]

TECHNOLOGY

Biomimetic peptide derived from Elafin

ANTI-FLACCID EFFECT

- Inhibits progerin synthesis

- Inhibits the activity of elastase

- Regulates the cohesion of the

epidermis

- Increases the contractility of

fibroblasts

MENYANTHES TRIFOLIATE - BOG BEAN

Preserves Vit C for collagen formacion

Absorbs peroxynitrate a cellular toxin

Contains triterpenes

Powerful anti oxidant

In-vitro test. Effect on the functionality

of photoaged human reticular

fibroblasts*

69

Non irradiated controlAdhesion:+++ (100%)Contraction:+++ (100%)Migration: +++ (100%)

Irradiated UVA controlAdhesion:+ (65%)Contraction : + (32%)Migration : ++ (75%)

UVA + Piper Nigrum ext. Adhesion:++ (83%)Contraction :++ (83%)Migration : +++ (94%)

*α-glucans and black pepper (Piper nigrum) rhamnogalacturonans.

Recover of the reticular cells funcionality on

photoaged skins.

[ProGEN-in]

TECHNOLOGY

70

Papillary dermis

(Intrincis ageing)

Reticular dermis

(Extrinsec ageing)

Menyanthes trifoliata ext.

Pro-colagen

Piper nigrum ext.

Reticular anti-photoageing

Peptide biomim. elafin

Anti-progerin

Anti-elastase

[ProGEN-in]

TECHNOLOGY

Global Lift demonstrates positive results with respect to facial

architecture parameters

Younger skin

EFFICACY TEST SUBJECT TO MEDICAL CONTROL*

Global firming effect

Redefined facial contour

Attenuation of wrinkles caused by loose skin

Lifting effect

Attenuation of eye contour (eye bags, dark circles)

Reduction in submental fat

Percentage of positive opinions

* In-Use Test: 20 volunteers, 28 days. Treatment: Antigravity Lifting Programme (4 sessions)* Redefining cream + Redefining eye contour cream

Anti-gravity lifting programmeRestores fullness to the contours of the face and neck

in the salon

Activating Firming Gel

A non-oily emollient gel that facilitates facial massage in the cabin. With tensor and firming properties.

Active substances:Menyanthes trifoliata, Clhorella Vulgaris, Probiotic Lysate, Amino Acids.

Anti-Gravity Serum

A serum formulated to produce a global lifting effect on the skinl. Specially formulated for treating loose, mature and photoaged skins. Contains hydrolysed collagen and organic silicon which strengthen the skin’s supportive properties.

Active substances: Biomimetic peptide derived from Elafin, Black Pepper, Collagen, Organic Silicon.

Immediate Lift Action Mask

A lifting mask for the face and neck with a wrinkle-ironing effect. It patch-like format gives spectacular and immediate firming results in a professional and effective manner.

Active substances: Yeast Cell Lysate, Asian Centella, Aloe Vera.

Lift Contour Cream

A face and neck cream based on the [ProGEN-in] anti-age technology. Advanced cosmetics for a global firming effect that restore fullness to the facial contour.

Active substances: [ProGEN-in]Tech., Algae Ext., Lupin Ext.

in the salon

Lift Contour Face & Neck CreamGlobal, firming effect, [ProGEN-in] technology.

Active substances: [ProGEN-in] Tech., Algae Ext., Lupin Ext.

Presented in two textures, depending on the skin type:

Dry skins: a rich, creamy texture and normal to combination skins: a lighter, non-oily texture.

at home

Lift Definition Eye Contour Cream

Triple orbicular effect, [ProGEN-in] technology.

Active substances: [ProGEN-in] Tech., Alga Ext., Buckwheat, Firming, anti-wrinkle lipopeptide.

76

Lift Definition Eye Contour CreamTriple orbicular effect, [ProGEN-in] technology

Effects:

• Firms the skin and reduces wrinkles.

• Attenuates eye bags.

• Relieves congestion in eyelids and eye bags.

Active substances:

• [ProGEN-in] technology.

• Alaris algae extract.

• Buckwheat.

• Firming anti-wrinkle lipopeptide.

ACTIVE SUBSTANCE

EFFECT

CLHORELLA

VULGARIS

Anti-elastase, anti-collagenase.

A green microalga, rich in proteins, vitamins and carotenes.

PROBIOTIC

LYSATE

Stimulates the skin’s defences.

Vitamins from the B group, trace elements (the lysate kills

the bacteria but conserves most of their activity).

COLLAGEN Moisturising and filler.

A protein forming part of the skin’s structure that makes the

skin elastic.

ASIAN

CENTELLA

Anti-age repair agent.

Has healing and renovating properties. It binds amino acids

to the collagen structure due to the effects of its triterpenes.

ACTIVE SUBSTANCE

EFFECT

BUCKWHEAT Has a specific effect on submental fat.

Anti-oedematous draining effect. Rich in rutin, a substance used to improve the blood circulation.

LUPIN EXTRACT

Redensifies the dermis.

Increases high quality collagen synthesis. Increases the firmness and elasticity of the facial contour.

ALOE VERA Moisturises, soothes and nourishes the skin.

Contains minerals and vitamins C and E, which have a specific

repairing effect on photo-aged skin.

ORGANIC SILICON

Increases the skin’s firmness and elasticity.

Plays a part in regenerating collagen and elastin. Increases the cohesion of the extracellular matrix.

Commercial arguments

79

Cross-Selling with other products

• Recommend Global Lift with Ssuplemets Antiedad

Reafirmante, rich in Collágen and Resveratrol.

80

Objetive: increase

lines of sale

• Two textures of home treatment creams ideal for all the clients summer and

winter.

• One treatment cream for the face and the neck.

• Treats the 3 problem areas of the face, cheeks ,neck and jawline.

• Immediate visible results with the salon treatment thanks to the mask with the

IRONING EFFECT.

• Eye cream is multi-tasking.

81

SALES ARGUMENTS

STEP BY STEP CABIN TREATMENT

1. Remove all traces of makeup

from the face with SKEYNDOR’s

special eye makeup remover

product. Exfoliate with the most

appropriate SKEYNDOR exfoliation

product.

2. To improve the treatment result,

massage the trapezius muscle and

cervical area to relax the neck and

relieve tension.

3. Apply the Activating Firming Gel

following the recommended

firming massage or use the

hydroelectricophoresis current for

6 to 8 minutes at negative polarity.

4. Apply the Anti-gravity serum and

ensure it penetrates in full with a

brisk massage or apply the

electroporation current for 6 to 8

minutes.

5. Remove all traces of surplus

product and apply the Immediate

Lift Action Mask, ensuring it

covers the face.

Leave on for 20 to 25 minutes and

remove in one piece.

6. End the treatment with the Lift

Contour Cream. Apply the

necessary quantity, depending on

the skin type.

TRATAMIENTO PASO A PASO