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Transcript of produce movement maintain posture stabilize joints generate heat move substances within the body...
• produce movement• maintain posture• stabilize joints• generate heat• move substances
within the body
Muscle Function
• Excitability- respond to a stimulus• Contractility- ability to shorten
forcibly when adequately stimulated
• Extensibility- the ability to be stretched
• Elasticity- the ability of a muscle fiber to resume its resting length after being stretched
Functional Characteristics
Skeletal Muscle
• Striated• Multinucleate• Voluntary
Cardiac Muscle
• Striated• Uninucleate• Involuntary• Branching• Intercalated discs
Smooth Muscle
• Unstriated• Uninucleate• Involuntary• Hollow walled
organs and blood vessels
Skeletal MuscleSkeletal MuscleConnective tissue sheaths of skeletal muscle:Connective tissue sheaths of skeletal muscle:
• Epimysium: dense regular connective tissue Epimysium: dense regular connective tissue surrounding entire muscle surrounding entire muscle
• Perimysium: fibrous connective tissue Perimysium: fibrous connective tissue surrounding fascicles (groups of muscle fibers)surrounding fascicles (groups of muscle fibers)
• Endomysium: fine areolar connective tissue Endomysium: fine areolar connective tissue surrounding each muscle fibersurrounding each muscle fiber
Figure 9.1
Bone
Perimysium
Endomysium(between individualmuscle fibers)
Muscle fiber
Fascicle(wrapped by perimysium)
Epimysium
Tendon
Epimysium
Muscle fiberin middle ofa fascicle
Blood vessel
PerimysiumEndomysium
Fascicle(a)
(b)
Gross Anatomy Skeletal Muscle
Muscle AnatomyMuscle Anatomy
myofibril
sarcomere
muscle fiber (cell)
Muscle CellMuscle CellSarcoplasmic
reticulum
SarcomereSarcomere
Myofibril
Myosin (Thick) FilamentMyosin (Thick) Filament
Actin (Thin) FilamentActin (Thin) Filament
Cross BridgesCross Bridges
Sliding Filament Hypothesis
No Calcium Ion
Calcium Ion Present
tropomyosin
troponin
myosin binding sites
actin
Actin & Myosin InteractionActin & Myosin Interaction
Biology 100Biology 100Human BiologyHuman Biology
Motor Unit
spinal cord
motor neurons
muscle bundle
muscle fibers
neuromuscular junctions
Neuromuscular Neuromuscular junctionsjunctions
branching axon branching axon to motor unitto motor unit
muscle fibersmuscle fibers
Axon(motor neuron)
sarcolemma
myofibrils
sarcomere
sarcoplasmSarcoplasmic Reticulum
Neuromuscular junction
T tubules
sarcoplasmic reticulum
http://www.youtube.com/watch?v=kvMFdNw35L0http://www.youtube.com/watch?v=Ct8AbZn_A8A
Stimulation of Skeletal Muscle
Figure 9.9
Na+
Na+
Open Na+
Channel
Closed Na+
Channel
Closed K+
Channel
Open K+
Channel
Action potential++++++
++++++
Axon terminal
Synapticcleft
ACh
ACh
Sarcoplasm of muscle fiber
K+
2 Generation and propagation ofthe action potential (AP)
3 Repolarization
1 Local depolarization: generation of the end plate potential on the sarcolemma
K+
K+Na+
K+Na+
Wave of dep
olar
izat
io n
Figure 9.9, step 1
Na+
Na+
Open Na+
ChannelClosed K+
Channel
K+
Na+ K+Action potential
+++++++++++
+
Axon terminal
Synapticcleft
ACh
ACh
Sarcoplasm of muscle fiber
K+
1 Local depolarization: generation of the end plate potential on the sarcolemma
1Wave of
depo
lariz
atio
n
Figure 9.9, step 2
Na+
Na+
Open Na+
ChannelClosed K+
Channel
K+
Na+ K+Action potential
+++++++++++
+
Axon terminal
Synapticcleft
ACh
ACh
Sarcoplasm of muscle fiber
K+
Generation and propagation of the action potential (AP)
1 Local depolarization: generation of the end plate potential on the sarcolemma
2
1Wave of
depo
lariz
atio
n
Figure 9.9, step 3
Na+
Closed Na+
ChannelOpen K+
Channel
K+
Repolarization3
Figure 9.9
Na+
Na+
Open Na+
ChannelClosed K+
Channel
Action potential++++++
++++++
Axon terminal
Synapticcleft
ACh
ACh
Sarcoplasm of muscle fiber
K+
2 Generation and propagation ofthe action potential (AP)
3 Repolarization
1 Local depolarization: generation of the end plate potential on the sarcolemma
K+
K+Na+
K+Na+
Wave of dep
olar
izat
io n
Closed Na+
ChannelOpen K+
Channel
Figure 9.10
Na+ channelsclose, K+ channelsopen
K+ channelsclose
Repolarizationdue to K+ exit
Threshold
Na+
channelsopen
Depolarizationdue to Na+ entry
Stimulation of Skeletal Muscle
Stimulation of Skeletal Muscle
Stimulation of Skeletal Muscle
Stimulation of Skeletal Muscle
Stimulation of Skeletal Muscle
Stimulation of Skeletal Muscle
Stimulation of Skeletal Muscle
Relaxation of Skeletal Muscle
Stimulation of Skeletal Muscle
Stimulation of Skeletal Muscle
Muscle TwitchMuscle Twitch
Contraction Contraction ResponseResponse
single twitches
wave summation tetanus
action potentials in motor neuron
Isotonic and Isometric ContractionsIsotonic and Isometric Contractions
Isotonic contraction • Contraction with a change in length• The muscle shortens and movement
occurs.
Isometric contraction • Contraction without any change in length• The muscle does not shorten and there is
no movement produced even though the muscle contracts.
Isotonic and Isometric ContractionsIsotonic and Isometric Contractions
Isotonic
Isometric
ATP is Generated by:1. creatine phosphate
ADP + creatine phosphatecreatine + ATP
2. lactic acid fermentationFrom stored glycogen via anaerobic glycolysis; glucosepyruvic acid (no O2) lactic acid
O2
3. aerobic respirationGlucose pyruvate acetyl CoA KrebsCO2
+ H2O + ATP
Energy for muscle contraction:Energy for muscle contraction:ATP is the only energy source ATP(ATPase + H2O) ADP + Pi
Slow-Twitch Versus Slow-Twitch Versus Fast-TwitchFast-Twitch
Muscle FibersMuscle Fibers
Muscle Fiber Types
• Fast glycolitic• Slow oxidative• Fast oxidative-glycolytic
Ratio- red:white (all 3 types in body)
• white muscle fibers• low myoglobin• anaerobic glycolysis• few mitochondria• fast twitch fibers• high glycogen stores• short bursts• fatigues easily
Fast glycolitic:
Slow oxidative: • red muscle• aerobic• high myoglobin• low glycogen stores• lots mitochondria• slow• long distance
Fast glycolitic-oxidative: • red pink• aerobic• fast• high myoglobin• intermediate amt. of
mitochondria• intermediate glycogen• intermediate fatigue resistance
Red vs White Muscle• long distance blue fin tuna- mostly
red meat• quick bursts- yellow tail- more white
meat
Sprinter- anaerobic respiration
Long distance Runner- aerobic respiration
Smooth Muscle FibersSmooth Muscle Fibers
• Mainly aerobic• Arranged in
opposing sheets
Smooth Muscle FibersSmooth Muscle Fibers
peristalsis
Cardiac TissueCardiac Tissue
• More mitochondria• Longer refractory period• Mainly aerobic respiration• Can use multiple fuel molecules
Disuse- atrophyMuscles must be physically active if they are to remain healthyCastCast- muscle strength can decrease at a rate of 5%/ day; can use e- stimulusAvoid muscle injuries:Avoid muscle injuries:
• warm up muscles- walk fast 5 minutes
• then stretch- avoids pulls and tares
Effects of Exercise
SteroidsSteroidsAnabolic steroids • similar to testosterone • large doses required for good
effect Side effects:
• overall - kidney and heart damage, aggressiveness
• females - sterility, facial hair, breast & uterine atrophy
• males - baldness, atrophy of testis
• cramp- sustained spasm or tetanic contraction; may be due to low blood sugar levels, electrolyte depletion, dehydration
• strain- muscle pull• spasm- tics
Muscle Injuries
• hernia- protrusion of organ through body cavity wall may be due to heavy wts.
Inquiry1. What is stored in SER?2. Which protein blocks the heads of myosin?3. When a neuron synapses with a muscle it is called---.4. The neuron going to a muscle is called ____.5. A muscle that shortens or lengthens is called ____.6. Which ion floods into the sarcolemma after stimulation by a
neuron?7. Which neurotransmitter binds to the sarcolemma?8. Which type of muscles undergo aerobic respiration?9. Which type of fuel is stored in muscle tissues?10.Which pigment is stored in muscles that has a high affinity
for oxygen?11.Which muscle tissue has intercalated discs?12.What is depolarization?