PLASMA INDUSTRIE HERAUSFORDERUNGEN UND … Industrie... · im Jahr 2011. Pharmaceutical Industry...

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ARGE Magdeburg 18. & 19. November 2016 PLASMA INDUSTRIE HERAUSFORDERUNGEN UND MÖGLICHKEITEN Die Unterschiede zwischen Plasma- und Pharmaindustrie Patrick Robert The Marketing Research Bureau, Inc.

Transcript of PLASMA INDUSTRIE HERAUSFORDERUNGEN UND … Industrie... · im Jahr 2011. Pharmaceutical Industry...

  • ARGEMagdeburg 18. & 19. November 2016

    PLASMA INDUSTRIEHERAUSFORDERUNGEN UND

    MGLICHKEITEN

    Die Unterschiede zwischen Plasma- und PharmaindustriePatrick Robert

    The Marketing Research Bureau, Inc.

  • Die in dieser Prsentation verwendeten Diagramme und Tabellen wurden aus Daten zusammengestellt, die aus Umfragen stammen, durchgefhrt vom Marketing Research Bureau (MRB) in rund 50 Lndern und verffentlicht in verschiedenen MRB Berichten.

    Alle Daten und Informationen stammen aus Quellen, die in der Regel die ffentlich zugnglich sind. Ihre Genauigkeit ist nicht garantiert und das Marketing Research Bureau bernimmt keine Haftung fr deren Gebrauch. 2016

    METHODE

  • Worin unterschiedt sich die Plasmaindustrie von der Pharmaindustrie?

    INHALT

    Ausgangsstoff und Verarbeitung Vertriebskanle und Mrkte Der menschliche Faktor

  • Die Unterschiede zwischen Plasma und Pharmaindustrie:

    INHALT

    Ausgangsstoff und Verarbeitung Vertriebskanle und Mrkte Der menschliche Faktor

  • Kostenstruktur der Herstellung von Plasmaprparatenund chemisch hergestellten Pharmazutika - 2011

    * Beinhaltet allgemeine Verwaltungskosten in der PharmaindustrieQuelle: Industrieberichte & Schtzungen, 2011

    Pharmaceutical Industry

    14.0%

    30.0%

    25.0%

    6.0%

    25.0%

    Plasma Industry

    57.0%

    10.0%

    9.0%

    10.0%

    14.0%

    Manuf. Costs & Raw Materials

    Sales & Marketing

    Research & Development

    General Administration

    Other *

    In der Plasmaindustrie stellt der Ausgangsstoff einen signifikant hheren Anteil der Produktionskosten dar als in der Pharmaindustrie: 57% vs. 14% im Jahr 2011

    Chart6

    0.14

    0.3

    0.25

    0.06

    0.25

    Pharmaceutical Industry

    Old_Data2004

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials70%

    Sales & Marketing13%

    Research & Development7%

    General Administration5%

    Other *5%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials19%

    Sales & Marketing34%

    Research & Development15%

    General Administration0%

    Other *32%

    100%

    * Includes General Administration in the Pharmaceutical Industry

    Old_Data2004

    Plasma Industry

    Nu-Data2011

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials57%

    Sales & Marketing10%

    Research & Development9%

    General Administration10%

    Other14%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials14%

    Sales & Marketing30%

    Research & Development25%

    General Administration6%

    Other25%

    100%

    Pharmaceutical Industry

    Nu-Data2011

    Plasma Industry

    Pharmaceutical Industry

    Chart7

    0.57

    0.1

    0.09

    0.1

    0.14

    Plasma Industry

    Old_Data2004

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials70%

    Sales & Marketing13%

    Research & Development7%

    General Administration5%

    Other *5%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials19%

    Sales & Marketing34%

    Research & Development15%

    General Administration0%

    Other *32%

    100%

    * Includes General Administration in the Pharmaceutical Industry

    Old_Data2004

    Plasma Industry

    Nu-Data2011

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials57%

    Sales & Marketing10%

    Research & Development9%

    General Administration10%

    Other *14%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials14%

    Sales & Marketing30%

    Research & Development25%

    General Administration6%

    Other *25%

    100%

    Pharmaceutical Industry

    Nu-Data2011

    Plasma Industry

    Pharmaceutical Industry

  • Pharmaceutical Industry

    19.0%

    34.0%15.0%

    32.0%

    Kostenstruktur der Herstellung von Plasmaprparatenund chemisch hergestellten Pharmazutika - 2004

    * Beinhaltet allgemeine Verwaltungskosten in der PharmaindustrieQuelle: Industrieberichte, 2005

    Plasma Industry

    70.0%

    13.0%

    7.0%

    5.0%5.0%

    Manuf. Costs & Raw Materials

    Sales & Marketing

    Research & Development

    General Administration

    Other

    Seit 2004 haben sich die Anteile anderer Komponenten der Arzneimittelkosten erhht: Im Jahr 2004 betrug der Rohstoff 70% im Vergleich zu 57% im Jahr 2011.

    Chart3

    0.19

    0.34

    0.15

    0

    0.32

    Pharmaceutical Industry

    Old_Data2004

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials70%

    Sales & Marketing13%

    Research & Development7%

    General Administration5%

    Other5%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials19%

    Sales & Marketing34%

    Research & Development15%

    General Administration0%

    Other *32%

    100%

    * Includes General Administration in the Pharmaceutical Industry

    Old_Data2004

    Plasma Industry

    Nu-Data2011

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials57%

    Sales & Marketing10%

    Research & Development9%

    General Administration10%

    Other14%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials14%

    Sales & Marketing30%

    Research & Development25%

    General Administration6%

    Other25%

    100%

    Pharmaceutical Industry

    Nu-Data2011

    Plasma Industry

    Pharmaceutical Industry

    Chart1

    0.7

    0.13

    0.07

    0.05

    0.05

    Plasma Industry

    Sheet1

    China Throughput Calculation4/23/07

    ThroughputThroughputCapacity

    InitialfiguresCorrectedfigures

    -20%

    20072010200720102010

    400160320128400

    25012020096500

    450160360128400

    35012028096400

    200160160128400

    70012056096200

    801206496500

    30012024096600

    100216801731,000

    200220160176400

    10016080128500

    10025680205600

    200160160128400

    3,4302802,744224600

    12096300

    12096500

    12096300

    1601281,000

    160128400

    160128450

    8064300

    12096200

    3428500

    3,4462,75710,850

    2004

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials70%

    Sales & Marketing13%

    Research & Development7%

    General Administration5%

    Other5%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials19%

    Sales & Marketing34%

    Research & Development15%

    General Administration0%

    Other *32%

    100%

    * Includes General Administration in the Pharmaceutical Industry

    2004

    Plasma Industry

    2011

    4/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials57%

    Sales & Marketing10%

    Research & Development9%

    General Administration10%

    Other14%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials14%

    Sales & Marketing30%

    Research & Development25%

    General Administration6%

    Other25%

    100%

    Pharmaceutical Industry

    2011

    Plasma Industry

    Pharmaceutical Industry

  • Plasma Industry

    57.0%

    10.0%

    9.0%

    10.0%

    14.0%

    Pharmaceutical Industry

    14.0%

    30.0%

    25.0%

    6.0%

    25.0%

    Weltweiter Pharmamarkt: $1.052,3 Milliarden (IMS), inkl. Generika

    Weltweiter Markt fr Plasmaprparate : $19,7 Milliarden

    Der weltweite Absatz der Plasmaindustrie stellt 0,18% des weltweiten Absatzes der Pharmaindustrie dar

    Chart1

    0.57

    0.1

    0.09

    0.1

    0.14

    Plasma Industry

    Sheet1

    China Throughput Calculation4/23/07

    ThroughputThroughputCapacity

    InitialfiguresCorrectedfigures

    -20%

    20072010200720102010

    400160320128400

    25012020096500

    450160360128400

    35012028096400

    200160160128400

    70012056096200

    801206496500

    30012024096600

    100216801731,000

    200220160176400

    10016080128500

    10025680205600

    200160160128400

    3,4302802,744224600

    12096300

    12096500

    12096300

    1601281,000

    160128400

    160128450

    8064300

    12096200

    3428500

    3,4462,75710,850

    2004

    6/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials70%

    Sales & Marketing13%

    Research & Development7%

    General Administration5%

    Other5%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials19%

    Sales & Marketing32%

    Research & Development15%

    General Administration6%

    Other *28%

    100%

    * Includes General Administration in the Pharmaceutical Industry

    2004

    Plasma Industry

    2011

    6/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials57%

    Sales & Marketing10%

    Research & Development9%

    General Administration10%

    Other14%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials14%

    Sales & Marketing30%

    Research & Development25%

    General Administration6%

    Other25%

    100%

    Manuf. Costs & Raw Materials

    Sales & Marketing

    Research & Development

    General Administration

    Other *

    Pharmaceutical Industry

    1

    1

    1

    1

    2011

    Plasma Industry

    Pharmaceutical Industry

    Chart2

    0.14

    0.3

    0.25

    0.06

    0.25

    Pharmaceutical Industry

    Sheet1

    China Throughput Calculation4/23/07

    ThroughputThroughputCapacity

    InitialfiguresCorrectedfigures

    -20%

    20072010200720102010

    400160320128400

    25012020096500

    450160360128400

    35012028096400

    200160160128400

    70012056096200

    801206496500

    30012024096600

    100216801731,000

    200220160176400

    10016080128500

    10025680205600

    200160160128400

    3,4302802,744224600

    12096300

    12096500

    12096300

    1601281,000

    160128400

    160128450

    8064300

    12096200

    3428500

    3,4462,75710,850

    2004

    6/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials70%

    Sales & Marketing13%

    Research & Development7%

    General Administration5%

    Other5%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials19%

    Sales & Marketing32%

    Research & Development15%

    General Administration6%

    Other *28%

    100%

    * Includes General Administration in the Pharmaceutical Industry

    2004

    Plasma Industry

    2011

    6/23/07

    Comparative Cost Structures of Plasma Protein Therapies and Chemical-based Pharmaceuticals

    Plasma

    Industry

    Manuf. Costs & Raw Materials57%

    Sales & Marketing10%

    Research & Development9%

    General Administration10%

    Other14%

    100%

    Pharmaceutical

    Industry

    Manuf. Costs & Raw Materials14%

    Sales & Marketing30%

    Research & Development25%

    General Administration6%

    Other25%

    100%

    Manuf. Costs & Raw Materials

    Sales & Marketing

    Research & Development

    General Administration

    Other *

    Pharmaceutical Industry

    1

    1

    1

    1

    2011

    Plasma Industry

    Pharmaceutical Industry

  • GLOBAL VOLUME OF PLASMA FOR FRACTIONATION1990 - 2014

    Recovered & Source in Liters

    42.645.0

    16.4

    19.722.3

    26.1

    27.2

    24.525.9

    33.636.8

    0.0

    5.0

    10.0

    15.0

    20.0

    25.0

    30.0

    35.0

    40.0

    45.0

    50.0

    1990 1993 1996 1999 2002 2004 2007 2010 2012 2013 2014

    Total volume in 2014: 45.0 Million Liters

    Plasmagewinnung hngt von Faktoren ab, die unabhnig von der Fraktionierungsindustrie sind, wie z.B. die wirtschaftliche Lage (Source-Plasma) und die Nachfrage nach Erythrozyten und anderen Blutbestandteilen (Recovered- Plasma)

    In den Jahren 2003/2004 fhrte ein berschuss an Plasma zu einer Korrektur. Die jhrliche Wachstumsrate des Plasmas betrug 6,3% ber zehn Jahre (2004-2014) und 4,3% ber 24 Jahre (1990-2014).

    Chart1

    16.38

    19.661

    22.323

    26.119

    27.175

    24.497

    25.925

    33.643

    36.792

    42.56665

    44.95875

    Total volume in 2014: 45.0 Million Liters

    Total

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION1990 - 2014Recovered & Source in Liters

    Population_2014

    World Population 2014 (UN)

    2014

    Middle East/Africa1,13615.7%

    North America3544.9%

    Asia & Pacific4,39060.7%

    South America6178.5%

    Europe74110.2%

    Total7,238100.0%

    Population_2014

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Plasma_Supply_Regions

    3/10/12

    Liters of Plasma (1000 liters)

    RecoveredSourceTotal

    Asia & Pacific1,4616,2277,689

    Middle East/ Africa32210042228

    North America2,09026,48228,5716

    Latin America44260502

    Europe4,4333,3437,775

    Total8,74736,21244,959

    Ratio Recovered to Source PlasmaRatio Recovered to Source Plasma

    RecoveredSourceRecovered+Source

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Plasma_Supply_Regions

    Total recovered & source: 44,959,000 liters

    Plasma for Fractionation by Region 2014(Recovered & Source)

    Plasma_Supply_Country

    3/10/12

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Australia325256581325256581

    China *- 04,9504,950- 05,2005,200

    India352- 0352352- 0352

    Japan402554956402554956

    Hong Kong3053530535

    Korea (Rep)201210411201210411

    Malaysia23- 02323- 023

    New Zealand51- 05151- 051

    Singapore82108210

    Taiwan30- 03030- 030

    Thailand30- 03030- 030

    Other Asia10- 01010- 010

    Sub-total Asia & Pacific1,4615,9777,4391,4616,2277,68917.1%

    Argentina14051451405145

    Brazil140- 0140140- 0140

    Chile15- 01515- 015

    Cuba1001511510015115

    Mexico5- 055- 05

    Uruguay12- 01212- 012

    Venezuela204060204060

    Other Latin America10- 01010- 010

    Sub-total Latin America44260502442605021.1%

    Canada24042432404243

    United States *1,95024,15326,1031,85026,47828,328

    Sub-total North America2,19024,15726,3462,09026,48228,57163.6%

    South Africa *10051051005105

    Iran1409523514095235

    Egypt5- 055- 05

    Morocco15- 01515- 015

    Israel47- 04747- 047

    Other Middle East/Africa15- 01515- 015

    Sub-total Middle East/Africa3221004223221004220.9%

    * 2014 Data

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Austria5056061050560610

    Belgium179- 0179179- 0179

    Bulgaria15- 01515- 015

    Croatia25- 02525- 025

    Czech Republic5045050050450500

    Denmark60- 06060- 060

    Finland60- 06060- 060

    France6898477368984773271.41

    Germany *1,2051,8503,0551,0201,7622,782

    Greece5- 055- 05

    Hungary81371188137118

    Italy836- 0836836- 0836

    Latvia10- 01010- 010

    Lithuania12- 01212- 012

    Macedonia5- 055- 05

    Netherlands150150300150150300

    Norway451055451055

    Poland2602028026020280

    Russia *110120230150270420

    Serbia15- 01515- 015

    Slovakia15- 01515- 015

    Slovenia25- 02525- 025

    Spain350- 0350350- 0350

    Sweden145- 0145145- 0145

    Switzerland80- 08080- 080

    Ukraine70- 07070- 070

    Other Europe30- 03030- 030

    Sub-total Europe4,5773,2817,8584,4333,3437,77517.3%

    World Total8,99233,57542,5678,74736,21244,959100.0%

    - 019%81%100%

    42,56744,959

    RecoveredApheresisTotal

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Kg. x 1000Kg. x 1000

    1,0641,124

    741741

    170.267179.835

    141141

    Total: 8,992,000 liters

    Total recovered: 8,747,000 liters

    Plasma for Fractionation by Region 2014(Recovered)

    Total: 33,575,000 liters

    Total source 36,212,000 liters

    Plasma for Fractionation by Region 2014(Source)

    Recovered

    Source

    Percentage Recovered & Source Plasma by Region - 2014

    Charts_Plasma_Coll

    Annual compounded growth rate (ACGR) from 1996 to 2012. Source plasma for fractionation0

    Annual compounded growth rate (ACGR) from 1996 to 2012. Recovered plasma for fractionation0157,356

    Annual compounded growth rate (ACGR) from 1996 to 2012. Total source & recovered plasma for fractionation01,123,969

    COMMERCIAL & NON-PROFIT ORGANIZATIONS

    (Thousand Liters)

    GrowthGrowth

    WORLD1990199319961999200220042007201020122013201410 years24 years

    Source Plasma9.812.814.917.618.616.318.225.627.933.636.28.3%5.6%

    Recovered Plasma6.66.97.48.58.58.27.88.18.99.08.70.7%1.2%

    Total16.419.722.326.127.224.525.933.636.842.645.06.3%4.3%

    Annual Growth Rate6.3%4.3%5.4%1.3%-5.1%1.9%9.1%4.6%7.6%10.5%

    Source Plasma9,81712,75614,92517,64818,63316,32818,15725,58327,85533,57536,212

    Recovered Plasma6,5636,9057,3988,4718,5428,1697,7688,0608,9378,9928,747

    Total16,38019,66122,32326,11927,17524,49725,92533,64336,79242,56744,959

    Increment (Liters x 000)3,2812,6623,7961,056-2,6781,4287,7183,1495,7752,392

    Charts_Plasma_Coll

    Global volume in 2014: 45.0 Million Liters

    Source Plasma

    Recovered Plasma

    Source Plasma

    Recovered Plasma

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION 1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    65 Plasma Fractionators worldwide

    Europe 1515

    Middle East/Africa 44

    Latin America 44

    Asia & Pacific 3838

    North America 44

    65

    Plasma Throughput 42.6 million liters worldwide

    Europe18,000

    Middle East/Africa1,450

    Asia & Pacific6,500

    Latin America330

    North America14,150

    40,430

    33000

    0.82

    Total volume in 2014: 45.0 Million Liters

    Total

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    TOTAL : 71 FRACTIONATION PLANTS

    Total Number of Fractionation Plants: 65

    REGIONAL DISTRIBUTION OF FRACTIONATION PLANTS 2014

    IGG_Charts

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014North America69.746%

    (Kilograms)RoW1.91%

    Europe42.028%

    Initial file, amended one table belowMiddle East3.72%

    1992*1994*1996*19982000200320052008201020122014Asia & Pacific27.418%

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703Latin America7.05%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006100%

    Asia & Pacific4,3284,4424,6645,2759,3839,6959,7968,48716,97618,21323,476

    Latin America1782931,1386388751,6372,2172,8854,1034,5836,979

    Middle East---6351,1931,6231,8451,7713,8253,8303,739

    Oceania485686473181,0281,5281,7542,8182,9053,4393,908

    Africa631183207335978129228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77685,151107,293122,332151,680

    1992-1996-Asia and Mid-East together

    Initial file, amended one table below

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014

    (Kilograms)

    1992*1994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,384

    Latin America1782931,1386388751,6372,2172,8854,1044,5836,979

    Middle East1002004006351,1931,6231,8451,7703,8253,8303,739

    RoW631183207335978119228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,680

    * Includes Oceania (Australia/NZ)

    * Amended: Middle East has been carved out from Asia and Pacific (100 Kg. in 1992, 200 in 1994 and 400 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    19921994199619982000200320052008201020122014

    9.914.517.617.119.727.031.643.151.459.469.7

    5.27.811.111.914.615.820.725.226.230.942.0

    4.34.84.95.610.411.211.611.319.921.727.4

    0.20.31.10.60.91.62.22.94.14.67.0

    0.10.20.40.61.21.61.81.83.83.83.7

    0.10.10.30.70.60.80.90.91.91.91.9

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    - 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0

    1992*1994*1996*19982000200320052008201020122014

    North America9.914.517.617.119.727.031.643.151.459.469.7

    Europe5.27.811.111.914.615.820.725.226.230.942.0

    Asia & Pacific*4.34.84.95.610.411.211.611.319.921.727.4

    RoW0.30.61.92.02.74.15.05.59.810.312.6

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    Annual

    Growth rate

    2005-2015

    19921994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,7039.2%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,0068.2%

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,38410.1%

    RoW3406101,8582,0052,6654,0724,9845,5419,84110,32812,58710.8%

    Total (000)19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,6809.2%

    0

    Total (MM)19.727.735.536.647.458.268.885.2107.3122.3151.7

    TOTAL : 71 FRACTIONATION PLANTS

    Global Plasma Throughput 2014: 42.2 million liters

    REGIONAL DISTRIBUTION OF FRACTIONATION THROUGHPUT 2014

    IGG_Charts

    * Includes Australia & New Zealand

    North America

    Europe

    Asia & Pacific*

    RoW

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    Pharma_Mkt

    IMS DataPharma market

    Africa13,213,166,396

    Asia major193,119,667,483

    Central America11,201,994,793

    Europe - Key Five211,585,009,569

    Europe - Other105,953,031,494

    Middle East5,505,595,391

    North America403,418,901,401

    South America67,665,782,195

    Southeast Asia40,646,773,783

    Total1,052,309,922,505

    Africa & Middle East18,718,761,787

    Asia & Pacific233,766,441,266

    Latin America78,867,776,988

    Europe317,538,041,063

    North America403,418,901,401

    Tally- 0

    Africa & Middle East1.8%18,718,761,787

    Asia & Pacific22.2%233,766,441,266

    Latin America7.5%78,867,776,988

    Europe30.2%317,538,041,063

    North America38.3%403,418,901,401

    Total100.0%- 0

    MRB DataPlasma market

    Latin America5.3%

    North America41.6%

    Africa & Middle East4.3%

    Asia & Pacific20.9%

    Europe27.9%

    Total100.0%

    0.2%

    Total (MM)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION (Percentage of Metric Tons)Total: 151.7 Metric Tons

    Pharma_Mkt

    Total: 8,992,000 liters

    Total market $1,052.3 Billion

    The Global Pharmaceutical Market by Region 2014(Source: IMS)

    Albumin_Chart

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.71176

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific121.9163.5162.0175.0176.2157.4157.5199.9237.8270.0412.4North America169.7

    Latin America8.58.632.223.122.824.529.232.934.238.143.7Latin America43.7

    Middle East---12.215.221.122.625.940.540.548.5Europe144.7

    Oceania5.04.64.94.74.64.95.06.56.96.97.6Asia & Pacific420.0

    Africa4.34.96.16.17.610.611.312.920.220.224.3Middle East/Africa72.8

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    1992-1996-Asia and Mid-East together

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific117.9157.5154.0175.0176.2157.4157.5199.9237.8270.0412.4

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East4.06.08.012.215.221.122.625.940.540.548.5

    Oceania5.04.64.94.74.64.95.06.56.96.97.6

    Africa4.34.96.16.17.610.611.312.920.220.224.3

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. in 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    Tally0.00.00.00.00.00.00.00.00.00.00.0

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific122.9162.1158.9179.7180.8162.3162.5206.4244.8276.9420.0

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East/Africa8.310.914.118.322.831.734.038.860.760.772.85.4%

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.96.9%

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. In 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand

    Total: 8,992,000 liters

    Total market $19.7 Billion

    The Global Plasma Proteins Market by Region 2014(Source: MRB)

    Albumin_Chart

    North America

    Europe

    Asia & Pacific

    Latin America

    Middle East/Africa

    WORLDWIDE ALBUMIN SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES BY REGION(Percentage of Metric Tons)Total: 850.9 Metric Tons

  • GLOBAL VOLUME OF PLASMA FOR FRACTIONATION 1990 - 2014Recovered & Source in Liters

    18.2

    33.6

    36.2

    9.0 8.7

    25.627.9

    16.3

    18.617.6

    14.912.8

    9.8

    6.6 6.9 7.48.5

    8.5 8.2 7.8 8.18.9

    0.0

    5.0

    10.0

    15.0

    20.0

    25.0

    30.0

    35.0

    40.0

    1990 1993 1996 1999 2002 2004 2007 2010 2012 2013 2014

    Global volume in 2014: 45.0 Million Liters

    Source Plasma

    Recovered Plasma

    Die jhrliche Wachstumsrate des Source-Plasmas betrug ber 10 Jahre (2004-2014) 8,3% und 0,7% fr Recovered Plasma. ber 24 Jahre (1990-2014) stieg die Source-Plasmagewinnung um 5,6% pro Jahr und 1,2% fr Recovered Plasma.

    Chart2

    9.8176.563

    12.7566.905

    14.9257.398

    17.6488.471

    18.6338.542

    16.3288.169

    18.1577.768

    25.5838.06

    27.8558.937

    33.5758.99165

    36.21178.74705

    Global volume in 2014: 45.0 Million Liters

    Source Plasma

    Recovered Plasma

    Source Plasma

    Recovered Plasma

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION 1990 - 2014Recovered & Source in Liters

    Population_2014

    World Population 2014 (UN)

    2014

    Middle East/Africa1,13615.7%

    North America3544.9%

    Asia & Pacific4,39060.7%

    South America6178.5%

    Europe74110.2%

    Total7,238100.0%

    Population_2014

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Plasma_Supply_Regions

    3/10/12

    Liters of Plasma (1000 liters)

    RecoveredSourceTotal

    Asia & Pacific1,4616,2277,689

    Middle East/ Africa32210042228

    North America2,09026,48228,5716

    Latin America44260502

    Europe4,4333,3437,775

    Total8,74736,21244,959

    Ratio Recovered to Source PlasmaRatio Recovered to Source Plasma

    RecoveredSourceRecovered+Source

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Plasma_Supply_Regions

    Total recovered & source: 44,959,000 liters

    Plasma for Fractionation by Region 2014(Recovered & Source)

    Plasma_Supply_Country

    3/10/12

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Australia325256581325256581

    China *- 04,9504,950- 05,2005,200

    India352- 0352352- 0352

    Japan402554956402554956

    Hong Kong3053530535

    Korea (Rep)201210411201210411

    Malaysia23- 02323- 023

    New Zealand51- 05151- 051

    Singapore82108210

    Taiwan30- 03030- 030

    Thailand30- 03030- 030

    Other Asia10- 01010- 010

    Sub-total Asia & Pacific1,4615,9777,4391,4616,2277,68917.1%

    Argentina14051451405145

    Brazil140- 0140140- 0140

    Chile15- 01515- 015

    Cuba1001511510015115

    Mexico5- 055- 05

    Uruguay12- 01212- 012

    Venezuela204060204060

    Other Latin America10- 01010- 010

    Sub-total Latin America44260502442605021.1%

    Canada24042432404243

    United States *1,95024,15326,1031,85026,47828,328

    Sub-total North America2,19024,15726,3462,09026,48228,57163.6%

    South Africa *10051051005105

    Iran1409523514095235

    Egypt5- 055- 05

    Morocco15- 01515- 015

    Israel47- 04747- 047

    Other Middle East/Africa15- 01515- 015

    Sub-total Middle East/Africa3221004223221004220.9%

    * 2014 Data

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Austria5056061050560610

    Belgium179- 0179179- 0179

    Bulgaria15- 01515- 015

    Croatia25- 02525- 025

    Czech Republic5045050050450500

    Denmark60- 06060- 060

    Finland60- 06060- 060

    France6898477368984773271.41

    Germany *1,2051,8503,0551,0201,7622,782

    Greece5- 055- 05

    Hungary81371188137118

    Italy836- 0836836- 0836

    Latvia10- 01010- 010

    Lithuania12- 01212- 012

    Macedonia5- 055- 05

    Netherlands150150300150150300

    Norway451055451055

    Poland2602028026020280

    Russia *110120230150270420

    Serbia15- 01515- 015

    Slovakia15- 01515- 015

    Slovenia25- 02525- 025

    Spain350- 0350350- 0350

    Sweden145- 0145145- 0145

    Switzerland80- 08080- 080

    Ukraine70- 07070- 070

    Other Europe30- 03030- 030

    Sub-total Europe4,5773,2817,8584,4333,3437,77517.3%

    World Total8,99233,57542,5678,74736,21244,959100.0%

    - 019%81%100%

    42,56744,959

    RecoveredApheresisTotal

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Kg. x 1000Kg. x 1000

    1,0641,124

    741741

    170.267179.835

    141141

    Total: 8,992,000 liters

    Total recovered: 8,747,000 liters

    Plasma for Fractionation by Region 2014(Recovered)

    Total: 33,575,000 liters

    Total source 36,212,000 liters

    Plasma for Fractionation by Region 2014(Source)

    Recovered

    Source

    Percentage Recovered & Source Plasma by Region - 2014

    Charts_Plasma_Coll

    Annual compounded growth rate (ACGR) from 1996 to 2012. Source plasma for fractionation0

    Annual compounded growth rate (ACGR) from 1996 to 2012. Recovered plasma for fractionation0157,356

    Annual compounded growth rate (ACGR) from 1996 to 2012. Total source & recovered plasma for fractionation01,123,969

    COMMERCIAL & NON-PROFIT ORGANIZATIONS

    (Thousand Liters)

    GrowthGrowth

    WORLD1990199319961999200220042007201020122013201410 years24 years

    Source Plasma9.812.814.917.618.616.318.225.627.933.636.28.3%5.6%

    Recovered Plasma6.66.97.48.58.58.27.88.18.99.08.70.7%1.2%

    Total16.419.722.326.127.224.525.933.636.842.645.06.3%4.3%

    Annual Growth Rate6.3%4.3%5.4%1.3%-5.1%1.9%9.1%4.6%7.6%10.5%

    Source Plasma9,81712,75614,92517,64818,63316,32818,15725,58327,85533,57536,212

    Recovered Plasma6,5636,9057,3988,4718,5428,1697,7688,0608,9378,9928,747

    Total16,38019,66122,32326,11927,17524,49725,92533,64336,79242,56744,959

    Increment (Liters x 000)3,2812,6623,7961,056-2,6781,4287,7183,1495,7752,392

    Charts_Plasma_Coll

    Global volume in 2014: 45.0 Million Liters

    Source Plasma

    Recovered Plasma

    Source Plasma

    Recovered Plasma

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION 1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    65 Plasma Fractionators worldwide

    Europe 1515

    Middle East/Africa 44

    Latin America 44

    Asia & Pacific 3838

    North America 44

    65

    Plasma Throughput 42.6 million liters worldwide

    Europe18,000

    Middle East/Africa1,450

    Asia & Pacific6,500

    Latin America330

    North America14,150

    40,430

    33000

    0.82

    Total volume in 2014: 45.0 Million Liters

    Total

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    TOTAL : 71 FRACTIONATION PLANTS

    Total Number of Fractionation Plants: 65

    REGIONAL DISTRIBUTION OF FRACTIONATION PLANTS 2014

    IGG_Charts

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014North America69.746%

    (Kilograms)RoW1.91%

    Europe42.028%

    Initial file, amended one table belowMiddle East3.72%

    1992*1994*1996*19982000200320052008201020122014Asia & Pacific27.418%

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703Latin America7.05%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006100%

    Asia & Pacific4,3284,4424,6645,2759,3839,6959,7968,48716,97618,21323,476

    Latin America1782931,1386388751,6372,2172,8854,1034,5836,979

    Middle East---6351,1931,6231,8451,7713,8253,8303,739

    Oceania485686473181,0281,5281,7542,8182,9053,4393,908

    Africa631183207335978129228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77685,151107,293122,332151,680

    1992-1996-Asia and Mid-East together

    Initial file, amended one table below

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014

    (Kilograms)

    1992*1994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,384

    Latin America1782931,1386388751,6372,2172,8854,1044,5836,979

    Middle East1002004006351,1931,6231,8451,7703,8253,8303,739

    RoW631183207335978119228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,680

    * Includes Oceania (Australia/NZ)

    * Amended: Middle East has been carved out from Asia and Pacific (100 Kg. in 1992, 200 in 1994 and 400 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    19921994199619982000200320052008201020122014

    9.914.517.617.119.727.031.643.151.459.469.7

    5.27.811.111.914.615.820.725.226.230.942.0

    4.34.84.95.610.411.211.611.319.921.727.4

    0.20.31.10.60.91.62.22.94.14.67.0

    0.10.20.40.61.21.61.81.83.83.83.7

    0.10.10.30.70.60.80.90.91.91.91.9

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    - 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0

    1992*1994*1996*19982000200320052008201020122014

    North America9.914.517.617.119.727.031.643.151.459.469.7

    Europe5.27.811.111.914.615.820.725.226.230.942.0

    Asia & Pacific*4.34.84.95.610.411.211.611.319.921.727.4

    RoW0.30.61.92.02.74.15.05.59.810.312.6

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    Annual

    Growth rate

    2005-2015

    19921994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,7039.2%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,0068.2%

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,38410.1%

    RoW3406101,8582,0052,6654,0724,9845,5419,84110,32812,58710.8%

    Total (000)19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,6809.2%

    0

    Total (MM)19.727.735.536.647.458.268.885.2107.3122.3151.7

    TOTAL : 71 FRACTIONATION PLANTS

    Global Plasma Throughput 2014: 42.2 million liters

    REGIONAL DISTRIBUTION OF FRACTIONATION THROUGHPUT 2014

    IGG_Charts

    * Includes Australia & New Zealand

    North America

    Europe

    Asia & Pacific*

    RoW

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    Pharma_Mkt

    IMS DataPharma market

    Africa13,213,166,396

    Asia major193,119,667,483

    Central America11,201,994,793

    Europe - Key Five211,585,009,569

    Europe - Other105,953,031,494

    Middle East5,505,595,391

    North America403,418,901,401

    South America67,665,782,195

    Southeast Asia40,646,773,783

    Total1,052,309,922,505

    Africa & Middle East18,718,761,787

    Asia & Pacific233,766,441,266

    Latin America78,867,776,988

    Europe317,538,041,063

    North America403,418,901,401

    Tally- 0

    Africa & Middle East1.8%18,718,761,787

    Asia & Pacific22.2%233,766,441,266

    Latin America7.5%78,867,776,988

    Europe30.2%317,538,041,063

    North America38.3%403,418,901,401

    Total100.0%- 0

    MRB DataPlasma market

    Latin America5.3%

    North America41.6%

    Africa & Middle East4.3%

    Asia & Pacific20.9%

    Europe27.9%

    Total100.0%

    0.2%

    Total (MM)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION (Percentage of Metric Tons)Total: 151.7 Metric Tons

    Pharma_Mkt

    Total: 8,992,000 liters

    Total market $1,052.3 Billion

    The Global Pharmaceutical Market by Region 2014(Source: IMS)

    Albumin_Chart

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.71176

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific121.9163.5162.0175.0176.2157.4157.5199.9237.8270.0412.4North America169.7

    Latin America8.58.632.223.122.824.529.232.934.238.143.7Latin America43.7

    Middle East---12.215.221.122.625.940.540.548.5Europe144.7

    Oceania5.04.64.94.74.64.95.06.56.96.97.6Asia & Pacific420.0

    Africa4.34.96.16.17.610.611.312.920.220.224.3Middle East/Africa72.8

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    1992-1996-Asia and Mid-East together

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific117.9157.5154.0175.0176.2157.4157.5199.9237.8270.0412.4

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East4.06.08.012.215.221.122.625.940.540.548.5

    Oceania5.04.64.94.74.64.95.06.56.96.97.6

    Africa4.34.96.16.17.610.611.312.920.220.224.3

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. in 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    Tally0.00.00.00.00.00.00.00.00.00.00.0

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific122.9162.1158.9179.7180.8162.3162.5206.4244.8276.9420.0

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East/Africa8.310.914.118.322.831.734.038.860.760.772.85.4%

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.96.9%

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. In 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand

    Total: 8,992,000 liters

    Total market $19.7 Billion

    The Global Plasma Proteins Market by Region 2014(Source: MRB)

    Albumin_Chart

    North America

    Europe

    Asia & Pacific

    Latin America

    Middle East/Africa

    WORLDWIDE ALBUMIN SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES BY REGION(Percentage of Metric Tons)Total: 850.9 Metric Tons

  • Europa stellt 10% der Weltbevlkerung dar und produziert 51% des weltweiten Recoverd-Plasma zur Fraktionierung

    World Population by Region - 2014

    South America8.5%

    Asia & Pacific60.7%

    Middle East/Africa15.7% North America

    4.9%Europe10.2%

    Source: PopulationReference Bureau

    Plasma for Fractionation by Region 2014(Recovered)

    Asia & Pacific16.7%

    Middle East/ Africa3.7%

    North America23.9%

    Latin America5.0%

    Europe50.7%

    Total recovered: 8,747,000 liters

    Chart5

    1136

    354

    4390

    617

    741

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Population_2014

    World Population 2014 (UN)

    2014

    Middle East/Africa1,13615.7%

    North America3544.9%

    Asia & Pacific4,39060.7%

    South America6178.5%

    Europe74110.2%

    Total7,238100.0%

    Population_2014

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Plasma_Supply_Regions

    3/10/12

    Liters of Plasma (1000 liters)

    RecoveredSourceTotal

    Asia & Pacific1,4616,2277,689

    Middle East/ Africa32210042228

    North America2,09026,48228,5716

    Latin America44260502

    Europe4,4333,3437,775

    Total8,74736,21244,959

    Ratio Recovered to Source PlasmaRatio Recovered to Source Plasma

    RecoveredSourceRecovered+Source

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Plasma_Supply_Regions

    Total recovered & source: 44,959,000 liters

    Plasma for Fractionation by Region 2014(Recovered & Source)

    Plasma_Supply_Country

    3/10/12

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Australia325256581325256581

    China *- 04,9504,950- 05,2005,200

    India352- 0352352- 0352

    Japan402554956402554956

    Hong Kong3053530535

    Korea (Rep)201210411201210411

    Malaysia23- 02323- 023

    New Zealand51- 05151- 051

    Singapore82108210

    Taiwan30- 03030- 030

    Thailand30- 03030- 030

    Other Asia10- 01010- 010

    Sub-total Asia & Pacific1,4615,9777,4391,4616,2277,68917.1%

    Argentina14051451405145

    Brazil140- 0140140- 0140

    Chile15- 01515- 015

    Cuba1001511510015115

    Mexico5- 055- 05

    Uruguay12- 01212- 012

    Venezuela204060204060

    Other Latin America10- 01010- 010

    Sub-total Latin America44260502442605021.1%

    Canada24042432404243

    United States *1,95024,15326,1031,85026,47828,328

    Sub-total North America2,19024,15726,3462,09026,48228,57163.6%

    South Africa *10051051005105

    Iran1409523514095235

    Egypt5- 055- 05

    Morocco15- 01515- 015

    Israel47- 04747- 047

    Other Middle East/Africa15- 01515- 015

    Sub-total Middle East/Africa3221004223221004220.9%

    * 2014 Data

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Austria5056061050560610

    Belgium179- 0179179- 0179

    Bulgaria15- 01515- 015

    Croatia25- 02525- 025

    Czech Republic5045050050450500

    Denmark60- 06060- 060

    Finland60- 06060- 060

    France6898477368984773271.41

    Germany *1,2051,8503,0551,0201,7622,782

    Greece5- 055- 05

    Hungary81371188137118

    Italy836- 0836836- 0836

    Latvia10- 01010- 010

    Lithuania12- 01212- 012

    Macedonia5- 055- 05

    Netherlands150150300150150300

    Norway451055451055

    Poland2602028026020280

    Russia *110120230150270420

    Serbia15- 01515- 015

    Slovakia15- 01515- 015

    Slovenia25- 02525- 025

    Spain350- 0350350- 0350

    Sweden145- 0145145- 0145

    Switzerland80- 08080- 080

    Ukraine70- 07070- 070

    Other Europe30- 03030- 030

    Sub-total Europe4,5773,2817,8584,4333,3437,77517.3%

    World Total8,99233,57542,5678,74736,21244,959100.0%

    - 019%81%100%

    42,56744,959

    RecoveredApheresisTotal

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Kg. x 1000Kg. x 1000

    1,0641,124

    741741

    170.267179.835

    141141

    Total: 8,992,000 liters

    Total recovered: 8,747,000 liters

    Plasma for Fractionation by Region 2014(Recovered)

    Total: 33,575,000 liters

    Total source 36,212,000 liters

    Plasma for Fractionation by Region 2014(Source)

    Recovered

    Source

    Percentage Recovered & Source Plasma by Region - 2014

    Charts_Plasma_Coll

    Annual compounded growth rate (ACGR) from 1996 to 2012. Source plasma for fractionation0

    Annual compounded growth rate (ACGR) from 1996 to 2012. Recovered plasma for fractionation0157,356

    Annual compounded growth rate (ACGR) from 1996 to 2012. Total source & recovered plasma for fractionation01,123,969

    COMMERCIAL & NON-PROFIT ORGANIZATIONS

    (Thousand Liters)

    GrowthGrowth

    WORLD1990199319961999200220042007201020122013201410 years24 years

    Source Plasma9.812.814.917.618.616.318.225.627.933.636.28.3%5.6%

    Recovered Plasma6.66.97.48.58.58.27.88.18.99.08.70.7%1.2%

    Total16.419.722.326.127.224.525.933.636.842.645.06.3%4.3%

    Annual Growth Rate6.3%4.3%5.4%1.3%-5.1%1.9%9.1%4.6%7.6%10.5%

    Source Plasma9,81712,75614,92517,64818,63316,32818,15725,58327,85533,57536,212

    Recovered Plasma6,5636,9057,3988,4718,5428,1697,7688,0608,9378,9928,747

    Total16,38019,66122,32326,11927,17524,49725,92533,64336,79242,56744,959

    Increment (Liters x 000)3,2812,6623,7961,056-2,6781,4287,7183,1495,7752,392

    Charts_Plasma_Coll

    Global volume in 2014: 45.0 Million Liters

    Source Plasma

    Recovered Plasma

    Source Plasma

    Recovered Plasma

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION 1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    65 Plasma Fractionators worldwide

    Europe 1515

    Middle East/Africa 44

    Latin America 44

    Asia & Pacific 3838

    North America 44

    65

    Plasma Throughput 42.6 million liters worldwide

    Europe18,000

    Middle East/Africa1,450

    Asia & Pacific6,500

    Latin America330

    North America14,150

    40,430

    33000

    0.82

    Total volume in 2014: 45.0 Million Liters

    Total

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    TOTAL : 71 FRACTIONATION PLANTS

    Total Number of Fractionation Plants: 65

    REGIONAL DISTRIBUTION OF FRACTIONATION PLANTS 2014

    IGG_Charts

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014North America69.746%

    (Kilograms)RoW1.91%

    Europe42.028%

    Initial file, amended one table belowMiddle East3.72%

    1992*1994*1996*19982000200320052008201020122014Asia & Pacific27.418%

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703Latin America7.05%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006100%

    Asia & Pacific4,3284,4424,6645,2759,3839,6959,7968,48716,97618,21323,476

    Latin America1782931,1386388751,6372,2172,8854,1034,5836,979

    Middle East---6351,1931,6231,8451,7713,8253,8303,739

    Oceania485686473181,0281,5281,7542,8182,9053,4393,908

    Africa631183207335978129228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77685,151107,293122,332151,680

    1992-1996-Asia and Mid-East together

    Initial file, amended one table below

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014

    (Kilograms)

    1992*1994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,384

    Latin America1782931,1386388751,6372,2172,8854,1044,5836,979

    Middle East1002004006351,1931,6231,8451,7703,8253,8303,739

    RoW631183207335978119228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,680

    * Includes Oceania (Australia/NZ)

    * Amended: Middle East has been carved out from Asia and Pacific (100 Kg. in 1992, 200 in 1994 and 400 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    19921994199619982000200320052008201020122014

    9.914.517.617.119.727.031.643.151.459.469.7

    5.27.811.111.914.615.820.725.226.230.942.0

    4.34.84.95.610.411.211.611.319.921.727.4

    0.20.31.10.60.91.62.22.94.14.67.0

    0.10.20.40.61.21.61.81.83.83.83.7

    0.10.10.30.70.60.80.90.91.91.91.9

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    - 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0

    1992*1994*1996*19982000200320052008201020122014

    North America9.914.517.617.119.727.031.643.151.459.469.7

    Europe5.27.811.111.914.615.820.725.226.230.942.0

    Asia & Pacific*4.34.84.95.610.411.211.611.319.921.727.4

    RoW0.30.61.92.02.74.15.05.59.810.312.6

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    Annual

    Growth rate

    2005-2015

    19921994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,7039.2%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,0068.2%

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,38410.1%

    RoW3406101,8582,0052,6654,0724,9845,5419,84110,32812,58710.8%

    Total (000)19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,6809.2%

    0

    Total (MM)19.727.735.536.647.458.268.885.2107.3122.3151.7

    TOTAL : 71 FRACTIONATION PLANTS

    Global Plasma Throughput 2014: 42.2 million liters

    REGIONAL DISTRIBUTION OF FRACTIONATION THROUGHPUT 2014

    IGG_Charts

    * Includes Australia & New Zealand

    North America

    Europe

    Asia & Pacific*

    RoW

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    Pharma_Mkt

    IMS DataPharma market

    Africa13,213,166,396

    Asia major193,119,667,483

    Central America11,201,994,793

    Europe - Key Five211,585,009,569

    Europe - Other105,953,031,494

    Middle East5,505,595,391

    North America403,418,901,401

    South America67,665,782,195

    Southeast Asia40,646,773,783

    Total1,052,309,922,505

    Africa & Middle East18,718,761,787

    Asia & Pacific233,766,441,266

    Latin America78,867,776,988

    Europe317,538,041,063

    North America403,418,901,401

    Tally- 0

    Africa & Middle East1.8%18,718,761,787

    Asia & Pacific22.2%233,766,441,266

    Latin America7.5%78,867,776,988

    Europe30.2%317,538,041,063

    North America38.3%403,418,901,401

    Total100.0%- 0

    MRB DataPlasma market

    Latin America5.3%

    North America41.6%

    Africa & Middle East4.3%

    Asia & Pacific20.9%

    Europe27.9%

    Total100.0%

    0.2%

    Total (MM)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION (Percentage of Metric Tons)Total: 151.7 Metric Tons

    Pharma_Mkt

    Total: 8,992,000 liters

    Total market $1,052.3 Billion

    The Global Pharmaceutical Market by Region 2014(Source: IMS)

    Albumin_Chart

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.71176

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific121.9163.5162.0175.0176.2157.4157.5199.9237.8270.0412.4North America169.7

    Latin America8.58.632.223.122.824.529.232.934.238.143.7Latin America43.7

    Middle East---12.215.221.122.625.940.540.548.5Europe144.7

    Oceania5.04.64.94.74.64.95.06.56.96.97.6Asia & Pacific420.0

    Africa4.34.96.16.17.610.611.312.920.220.224.3Middle East/Africa72.8

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    1992-1996-Asia and Mid-East together

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific117.9157.5154.0175.0176.2157.4157.5199.9237.8270.0412.4

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East4.06.08.012.215.221.122.625.940.540.548.5

    Oceania5.04.64.94.74.64.95.06.56.96.97.6

    Africa4.34.96.16.17.610.611.312.920.220.224.3

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. in 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    Tally0.00.00.00.00.00.00.00.00.00.00.0

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific122.9162.1158.9179.7180.8162.3162.5206.4244.8276.9420.0

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East/Africa8.310.914.118.322.831.734.038.860.760.772.85.4%

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.96.9%

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. In 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand

    Total: 8,992,000 liters

    Total market $19.7 Billion

    The Global Plasma Proteins Market by Region 2014(Source: MRB)

    Albumin_Chart

    North America

    Europe

    Asia & Pacific

    Latin America

    Middle East/Africa

    WORLDWIDE ALBUMIN SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES BY REGION(Percentage of Metric Tons)Total: 850.9 Metric Tons

    Chart4

    1461.4

    322

    2089.6

    441.55

    4432.5

    Total: 8,992,000 liters

    Total recovered: 8,747,000 liters

    Plasma for Fractionation by Region 2014(Recovered)

    Population_2014

    World Population 2014 (UN)

    2014

    Middle East/Africa1,13615.7%

    North America3544.9%

    Asia & Pacific4,39060.7%

    South America6178.5%

    Europe74110.2%

    Total7,238100.0%

    Population_2014

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Plasma_Supply_Regions

    3/10/12

    Liters of Plasma (1000 liters)

    RecoveredSourceTotal

    Asia & Pacific1,4616,2277,689

    Middle East/ Africa32210042228

    North America2,09026,48228,5716

    Latin America44260502

    Europe4,4333,3437,775

    Total8,74736,21244,959

    Ratio Recovered to Source PlasmaRatio Recovered to Source Plasma

    RecoveredSourceRecovered+Source

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Plasma_Supply_Regions

    Total recovered & source: 44,959,000 liters

    Plasma for Fractionation by Region 2014(Recovered & Source)

    Plasma_Supply_Country

    3/10/12

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Australia325256581325256581

    China *- 04,9504,950- 05,2005,200

    India352- 0352352- 0352

    Japan402554956402554956

    Hong Kong3053530535

    Korea (Rep)201210411201210411

    Malaysia23- 02323- 023

    New Zealand51- 05151- 051

    Singapore82108210

    Taiwan30- 03030- 030

    Thailand30- 03030- 030

    Other Asia10- 01010- 010

    Sub-total Asia & Pacific1,4615,9777,4391,4616,2277,68917.1%

    Argentina14051451405145

    Brazil140- 0140140- 0140

    Chile15- 01515- 015

    Cuba1001511510015115

    Mexico5- 055- 05

    Uruguay12- 01212- 012

    Venezuela204060204060

    Other Latin America10- 01010- 010

    Sub-total Latin America44260502442605021.1%

    Canada24042432404243

    United States *1,95024,15326,1031,85026,47828,328

    Sub-total North America2,19024,15726,3462,09026,48228,57163.6%

    South Africa *10051051005105

    Iran1409523514095235

    Egypt5- 055- 05

    Morocco15- 01515- 015

    Israel47- 04747- 047

    Other Middle East/Africa15- 01515- 015

    Sub-total Middle East/Africa3221004223221004220.9%

    * 2014 Data

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Austria5056061050560610

    Belgium179- 0179179- 0179

    Bulgaria15- 01515- 015

    Croatia25- 02525- 025

    Czech Republic5045050050450500

    Denmark60- 06060- 060

    Finland60- 06060- 060

    France6898477368984773271.41

    Germany *1,2051,8503,0551,0201,7622,782

    Greece5- 055- 05

    Hungary81371188137118

    Italy836- 0836836- 0836

    Latvia10- 01010- 010

    Lithuania12- 01212- 012

    Macedonia5- 055- 05

    Netherlands150150300150150300

    Norway451055451055

    Poland2602028026020280

    Russia *110120230150270420

    Serbia15- 01515- 015

    Slovakia15- 01515- 015

    Slovenia25- 02525- 025

    Spain350- 0350350- 0350

    Sweden145- 0145145- 0145

    Switzerland80- 08080- 080

    Ukraine70- 07070- 070

    Other Europe30- 03030- 030

    Sub-total Europe4,5773,2817,8584,4333,3437,77517.3%

    World Total8,99233,57542,5678,74736,21244,959100.0%

    - 019%81%100%

    42,56744,959

    RecoveredApheresisTotal

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Kg. x 1000Kg. x 1000

    1,0641,124

    741741

    170.267179.835

    141141

    Total: 8,992,000 liters

    Total recovered: 8,747,000 liters

    Plasma for Fractionation by Region 2014(Recovered)

    Total: 33,575,000 liters

    Total source 36,212,000 liters

    Plasma for Fractionation by Region 2014(Source)

    Recovered

    Source

    Percentage Recovered & Source Plasma by Region - 2014

    Charts_Plasma_Coll

    Annual compounded growth rate (ACGR) from 1996 to 2012. Source plasma for fractionation0

    Annual compounded growth rate (ACGR) from 1996 to 2012. Recovered plasma for fractionation0157,356

    Annual compounded growth rate (ACGR) from 1996 to 2012. Total source & recovered plasma for fractionation01,123,969

    COMMERCIAL & NON-PROFIT ORGANIZATIONS

    (Thousand Liters)

    GrowthGrowth

    WORLD1990199319961999200220042007201020122013201410 years24 years

    Source Plasma9.812.814.917.618.616.318.225.627.933.636.28.3%5.6%

    Recovered Plasma6.66.97.48.58.58.27.88.18.99.08.70.7%1.2%

    Total16.419.722.326.127.224.525.933.636.842.645.06.3%4.3%

    Annual Growth Rate6.3%4.3%5.4%1.3%-5.1%1.9%9.1%4.6%7.6%10.5%

    Source Plasma9,81712,75614,92517,64818,63316,32818,15725,58327,85533,57536,212

    Recovered Plasma6,5636,9057,3988,4718,5428,1697,7688,0608,9378,9928,747

    Total16,38019,66122,32326,11927,17524,49725,92533,64336,79242,56744,959

    Increment (Liters x 000)3,2812,6623,7961,056-2,6781,4287,7183,1495,7752,392

    Charts_Plasma_Coll

    Global volume in 2014: 45.0 Million Liters

    Source Plasma

    Recovered Plasma

    Source Plasma

    Recovered Plasma

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION 1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    65 Plasma Fractionators worldwide

    Europe 1515

    Middle East/Africa 44

    Latin America 44

    Asia & Pacific 3838

    North America 44

    65

    Plasma Throughput 42.6 million liters worldwide

    Europe18,000

    Middle East/Africa1,450

    Asia & Pacific6,500

    Latin America330

    North America14,150

    40,430

    33000

    0.82

    Total volume in 2014: 45.0 Million Liters

    Total

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    TOTAL : 71 FRACTIONATION PLANTS

    Total Number of Fractionation Plants: 65

    REGIONAL DISTRIBUTION OF FRACTIONATION PLANTS 2014

    IGG_Charts

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014North America69.746%

    (Kilograms)RoW1.91%

    Europe42.028%

    Initial file, amended one table belowMiddle East3.72%

    1992*1994*1996*19982000200320052008201020122014Asia & Pacific27.418%

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703Latin America7.05%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006100%

    Asia & Pacific4,3284,4424,6645,2759,3839,6959,7968,48716,97618,21323,476

    Latin America1782931,1386388751,6372,2172,8854,1034,5836,979

    Middle East---6351,1931,6231,8451,7713,8253,8303,739

    Oceania485686473181,0281,5281,7542,8182,9053,4393,908

    Africa631183207335978129228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77685,151107,293122,332151,680

    1992-1996-Asia and Mid-East together

    Initial file, amended one table below

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014

    (Kilograms)

    1992*1994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,384

    Latin America1782931,1386388751,6372,2172,8854,1044,5836,979

    Middle East1002004006351,1931,6231,8451,7703,8253,8303,739

    RoW631183207335978119228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,680

    * Includes Oceania (Australia/NZ)

    * Amended: Middle East has been carved out from Asia and Pacific (100 Kg. in 1992, 200 in 1994 and 400 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    19921994199619982000200320052008201020122014

    9.914.517.617.119.727.031.643.151.459.469.7

    5.27.811.111.914.615.820.725.226.230.942.0

    4.34.84.95.610.411.211.611.319.921.727.4

    0.20.31.10.60.91.62.22.94.14.67.0

    0.10.20.40.61.21.61.81.83.83.83.7

    0.10.10.30.70.60.80.90.91.91.91.9

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    - 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0

    1992*1994*1996*19982000200320052008201020122014

    North America9.914.517.617.119.727.031.643.151.459.469.7

    Europe5.27.811.111.914.615.820.725.226.230.942.0

    Asia & Pacific*4.34.84.95.610.411.211.611.319.921.727.4

    RoW0.30.61.92.02.74.15.05.59.810.312.6

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    Annual

    Growth rate

    2005-2015

    19921994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,7039.2%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,0068.2%

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,38410.1%

    RoW3406101,8582,0052,6654,0724,9845,5419,84110,32812,58710.8%

    Total (000)19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,6809.2%

    0

    Total (MM)19.727.735.536.647.458.268.885.2107.3122.3151.7

    TOTAL : 71 FRACTIONATION PLANTS

    Global Plasma Throughput 2014: 42.2 million liters

    REGIONAL DISTRIBUTION OF FRACTIONATION THROUGHPUT 2014

    IGG_Charts

    * Includes Australia & New Zealand

    North America

    Europe

    Asia & Pacific*

    RoW

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    Pharma_Mkt

    IMS DataPharma market

    Africa13,213,166,396

    Asia major193,119,667,483

    Central America11,201,994,793

    Europe - Key Five211,585,009,569

    Europe - Other105,953,031,494

    Middle East5,505,595,391

    North America403,418,901,401

    South America67,665,782,195

    Southeast Asia40,646,773,783

    Total1,052,309,922,505

    Africa & Middle East18,718,761,787

    Asia & Pacific233,766,441,266

    Latin America78,867,776,988

    Europe317,538,041,063

    North America403,418,901,401

    Tally- 0

    Africa & Middle East1.8%18,718,761,787

    Asia & Pacific22.2%233,766,441,266

    Latin America7.5%78,867,776,988

    Europe30.2%317,538,041,063

    North America38.3%403,418,901,401

    Total100.0%- 0

    MRB DataPlasma market

    Latin America5.3%

    North America41.6%

    Africa & Middle East4.3%

    Asia & Pacific20.9%

    Europe27.9%

    Total100.0%

    0.2%

    Total (MM)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION (Percentage of Metric Tons)Total: 151.7 Metric Tons

    Pharma_Mkt

    Total: 8,992,000 liters

    Total market $1,052.3 Billion

    The Global Pharmaceutical Market by Region 2014(Source: IMS)

    Albumin_Chart

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.71176

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific121.9163.5162.0175.0176.2157.4157.5199.9237.8270.0412.4North America169.7

    Latin America8.58.632.223.122.824.529.232.934.238.143.7Latin America43.7

    Middle East---12.215.221.122.625.940.540.548.5Europe144.7

    Oceania5.04.64.94.74.64.95.06.56.96.97.6Asia & Pacific420.0

    Africa4.34.96.16.17.610.611.312.920.220.224.3Middle East/Africa72.8

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    1992-1996-Asia and Mid-East together

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific117.9157.5154.0175.0176.2157.4157.5199.9237.8270.0412.4

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East4.06.08.012.215.221.122.625.940.540.548.5

    Oceania5.04.64.94.74.64.95.06.56.96.97.6

    Africa4.34.96.16.17.610.611.312.920.220.224.3

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. in 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    Tally0.00.00.00.00.00.00.00.00.00.00.0

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific122.9162.1158.9179.7180.8162.3162.5206.4244.8276.9420.0

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East/Africa8.310.914.118.322.831.734.038.860.760.772.85.4%

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.96.9%

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. In 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand

    Total: 8,992,000 liters

    Total market $19.7 Billion

    The Global Plasma Proteins Market by Region 2014(Source: MRB)

    Albumin_Chart

    North America

    Europe

    Asia & Pacific

    Latin America

    Middle East/Africa

    WORLDWIDE ALBUMIN SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES BY REGION(Percentage of Metric Tons)Total: 850.9 Metric Tons

  • Nordamerika betrgt 5% der Weltbevlkerung und produziert 73% des weltweiten Source-Plasma zur Fraktionierung

    World Population by Region - 2014

    South America8.5%

    Asia & Pacific60.7%

    Middle East/Africa15.7% North America

    4.9%Europe10.2%

    Source: PopulationReference Bureau

    Plasma for Fractionation by Region 2014(Source)

    North America73.1%

    Asia & Pacific17.2%

    Latin America0.2%

    Europe9.2%

    Middle East/ Africa0.3%

    Total source 36,212,000 liters

    Chart4

    1136

    354

    4390

    617

    741

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Population_2014

    World Population 2014 (UN)

    2014

    Middle East/Africa1,13615.7%

    North America3544.9%

    Asia & Pacific4,39060.7%

    South America6178.5%

    Europe74110.2%

    Total7,238100.0%

    Population_2014

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Plasma_Supply_Regions

    3/10/12

    Liters of Plasma (1000 liters)

    RecoveredSourceTotal

    Asia & Pacific1,4616,2277,689

    Middle East/ Africa32210042228

    North America2,09026,48228,5716

    Latin America44260502

    Europe4,4333,3437,775

    Total8,74736,21244,959

    Ratio Recovered to Source PlasmaRatio Recovered to Source Plasma

    RecoveredSourceRecovered+Source

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Plasma_Supply_Regions

    Total recovered & source: 44,959,000 liters

    Plasma for Fractionation by Region 2014(Recovered & Source)

    Plasma_Supply_Country

    3/10/12

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Australia325256581325256581

    China *- 04,9504,950- 05,2005,200

    India352- 0352352- 0352

    Japan402554956402554956

    Hong Kong3053530535

    Korea (Rep)201210411201210411

    Malaysia23- 02323- 023

    New Zealand51- 05151- 051

    Singapore82108210

    Taiwan30- 03030- 030

    Thailand30- 03030- 030

    Other Asia10- 01010- 010

    Sub-total Asia & Pacific1,4615,9777,4391,4616,2277,68917.1%

    Argentina14051451405145

    Brazil140- 0140140- 0140

    Chile15- 01515- 015

    Cuba1001511510015115

    Mexico5- 055- 05

    Uruguay12- 01212- 012

    Venezuela204060204060

    Other Latin America10- 01010- 010

    Sub-total Latin America44260502442605021.1%

    Canada24042432404243

    United States *1,95024,15326,1031,85026,47828,328

    Sub-total North America2,19024,15726,3462,09026,48228,57163.6%

    South Africa *10051051005105

    Iran1409523514095235

    Egypt5- 055- 05

    Morocco15- 01515- 015

    Israel47- 04747- 047

    Other Middle East/Africa15- 01515- 015

    Sub-total Middle East/Africa3221004223221004220.9%

    * 2014 Data

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Austria5056061050560610

    Belgium179- 0179179- 0179

    Bulgaria15- 01515- 015

    Croatia25- 02525- 025

    Czech Republic5045050050450500

    Denmark60- 06060- 060

    Finland60- 06060- 060

    France6898477368984773271.41

    Germany *1,2051,8503,0551,0201,7622,782

    Greece5- 055- 05

    Hungary81371188137118

    Italy836- 0836836- 0836

    Latvia10- 01010- 010

    Lithuania12- 01212- 012

    Macedonia5- 055- 05

    Netherlands150150300150150300

    Norway451055451055

    Poland2602028026020280

    Russia *110120230150270420

    Serbia15- 01515- 015

    Slovakia15- 01515- 015

    Slovenia25- 02525- 025

    Spain350- 0350350- 0350

    Sweden145- 0145145- 0145

    Switzerland80- 08080- 080

    Ukraine70- 07070- 070

    Other Europe30- 03030- 030

    Sub-total Europe4,5773,2817,8584,4333,3437,77517.3%

    World Total8,99233,57542,5678,74736,21244,959100.0%

    - 019%81%100%

    42,56744,959

    RecoveredApheresisTotal

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Kg. x 1000Kg. x 1000

    1,0641,124

    741741

    170.267179.835

    141141

    Total: 8,992,000 liters

    Total recovered: 8,747,000 liters

    Plasma for Fractionation by Region 2014(Recovered)

    Total: 33,575,000 liters

    Total source 36,212,000 liters

    Plasma for Fractionation by Region 2014(Source)

    Recovered

    Source

    Percentage Recovered & Source Plasma by Region - 2014

    Charts_Plasma_Coll

    Annual compounded growth rate (ACGR) from 1996 to 2012. Source plasma for fractionation0

    Annual compounded growth rate (ACGR) from 1996 to 2012. Recovered plasma for fractionation0157,356

    Annual compounded growth rate (ACGR) from 1996 to 2012. Total source & recovered plasma for fractionation01,123,969

    COMMERCIAL & NON-PROFIT ORGANIZATIONS

    (Thousand Liters)

    GrowthGrowth

    WORLD1990199319961999200220042007201020122013201410 years24 years

    Source Plasma9.812.814.917.618.616.318.225.627.933.636.28.3%5.6%

    Recovered Plasma6.66.97.48.58.58.27.88.18.99.08.70.7%1.2%

    Total16.419.722.326.127.224.525.933.636.842.645.06.3%4.3%

    Annual Growth Rate6.3%4.3%5.4%1.3%-5.1%1.9%9.1%4.6%7.6%10.5%

    Source Plasma9,81712,75614,92517,64818,63316,32818,15725,58327,85533,57536,212

    Recovered Plasma6,5636,9057,3988,4718,5428,1697,7688,0608,9378,9928,747

    Total16,38019,66122,32326,11927,17524,49725,92533,64336,79242,56744,959

    Increment (Liters x 000)3,2812,6623,7961,056-2,6781,4287,7183,1495,7752,392

    Charts_Plasma_Coll

    Global volume in 2014: 45.0 Million Liters

    Source Plasma

    Recovered Plasma

    Source Plasma

    Recovered Plasma

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION 1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    65 Plasma Fractionators worldwide

    Europe 1515

    Middle East/Africa 44

    Latin America 44

    Asia & Pacific 3838

    North America 44

    65

    Plasma Throughput 42.6 million liters worldwide

    Europe18,000

    Middle East/Africa1,450

    Asia & Pacific6,500

    Latin America330

    North America14,150

    40,430

    33000

    0.82

    Total volume in 2014: 45.0 Million Liters

    Total

    GLOBAL VOLUME OF PLASMA FOR FRACTIONATION1990 - 2014Recovered & Source in Liters

    Charts_Fractionators

    TOTAL : 71 FRACTIONATION PLANTS

    Total Number of Fractionation Plants: 65

    REGIONAL DISTRIBUTION OF FRACTIONATION PLANTS 2014

    IGG_Charts

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014North America69.746%

    (Kilograms)RoW1.91%

    Europe42.028%

    Initial file, amended one table belowMiddle East3.72%

    1992*1994*1996*19982000200320052008201020122014Asia & Pacific27.418%

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703Latin America7.05%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006100%

    Asia & Pacific4,3284,4424,6645,2759,3839,6959,7968,48716,97618,21323,476

    Latin America1782931,1386388751,6372,2172,8854,1034,5836,979

    Middle East---6351,1931,6231,8451,7713,8253,8303,739

    Oceania485686473181,0281,5281,7542,8182,9053,4393,908

    Africa631183207335978129228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77685,151107,293122,332151,680

    1992-1996-Asia and Mid-East together

    Initial file, amended one table below

    WORLDWIDE POLYVALENT INTRAVENOUS AND SUBCUTANEOUS IMMUNE GLOBULIN SALES FROM 1992 TO 2014

    (Kilograms)

    1992*1994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,703

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,006

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,384

    Latin America1782931,1386388751,6372,2172,8854,1044,5836,979

    Middle East1002004006351,1931,6231,8451,7703,8253,8303,739

    RoW631183207335978119228851,9131,9151,869

    Total19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,680

    * Includes Oceania (Australia/NZ)

    * Amended: Middle East has been carved out from Asia and Pacific (100 Kg. in 1992, 200 in 1994 and 400 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    19921994199619982000200320052008201020122014

    9.914.517.617.119.727.031.643.151.459.469.7

    5.27.811.111.914.615.820.725.226.230.942.0

    4.34.84.95.610.411.211.611.319.921.727.4

    0.20.31.10.60.91.62.22.94.14.67.0

    0.10.20.40.61.21.61.81.83.83.83.7

    0.10.10.30.70.60.80.90.91.91.91.9

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    - 0- 0- 0- 0- 0- 0- 0- 0- 0- 0- 0

    1992*1994*1996*19982000200320052008201020122014

    North America9.914.517.617.119.727.031.643.151.459.469.7

    Europe5.27.811.111.914.615.820.725.226.230.942.0

    Asia & Pacific*4.34.84.95.610.411.211.611.319.921.727.4

    RoW0.30.61.92.02.74.15.05.59.810.312.6

    Total19.727.735.536.647.458.268.885.2107.3122.3151.7

    Annual

    Growth rate

    2005-2015

    19921994*1996*19982000200320052008201020122014

    North America9,91514,51517,59317,11019,68027,02531,57943,13551,42059,44069,7039.2%

    Europe5,2057,80211,13011,93814,64315,83120,66425,17026,15230,91242,0068.2%

    Asia & Pacific*4,2764,8104,9115,59310,41111,22311,55011,30519,88121,65227,38410.1%

    RoW3406101,8582,0052,6654,0724,9845,5419,84110,32812,58710.8%

    Total (000)19,73627,73735,49236,64547,39958,15068,77785,150107,294122,332151,6809.2%

    0

    Total (MM)19.727.735.536.647.458.268.885.2107.3122.3151.7

    TOTAL : 71 FRACTIONATION PLANTS

    Global Plasma Throughput 2014: 42.2 million liters

    REGIONAL DISTRIBUTION OF FRACTIONATION THROUGHPUT 2014

    IGG_Charts

    * Includes Australia & New Zealand

    North America

    Europe

    Asia & Pacific*

    RoW

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    Pharma_Mkt

    IMS DataPharma market

    Africa13,213,166,396

    Asia major193,119,667,483

    Central America11,201,994,793

    Europe - Key Five211,585,009,569

    Europe - Other105,953,031,494

    Middle East5,505,595,391

    North America403,418,901,401

    South America67,665,782,195

    Southeast Asia40,646,773,783

    Total1,052,309,922,505

    Africa & Middle East18,718,761,787

    Asia & Pacific233,766,441,266

    Latin America78,867,776,988

    Europe317,538,041,063

    North America403,418,901,401

    Tally- 0

    Africa & Middle East1.8%18,718,761,787

    Asia & Pacific22.2%233,766,441,266

    Latin America7.5%78,867,776,988

    Europe30.2%317,538,041,063

    North America38.3%403,418,901,401

    Total100.0%- 0

    MRB DataPlasma market

    Latin America5.3%

    North America41.6%

    Africa & Middle East4.3%

    Asia & Pacific20.9%

    Europe27.9%

    Total100.0%

    0.2%

    Total (MM)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE POLYVALENT IMMUNE GLOBULIN (IVIG/SCIG) SALES BY REGION (Percentage of Metric Tons)Total: 151.7 Metric Tons

    Pharma_Mkt

    Total: 8,992,000 liters

    Total market $1,052.3 Billion

    The Global Pharmaceutical Market by Region 2014(Source: IMS)

    Albumin_Chart

    2/17/12

    Worldwide - Kilograms of IGIV (Polyvalent)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.71176

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific121.9163.5162.0175.0176.2157.4157.5199.9237.8270.0412.4North America169.7

    Latin America8.58.632.223.122.824.529.232.934.238.143.7Latin America43.7

    Middle East---12.215.221.122.625.940.540.548.5Europe144.7

    Oceania5.04.64.94.74.64.95.06.56.96.97.6Asia & Pacific420.0

    Africa4.34.96.16.17.610.611.312.920.220.224.3Middle East/Africa72.8

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    1992-1996-Asia and Mid-East together

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific117.9157.5154.0175.0176.2157.4157.5199.9237.8270.0412.4

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East4.06.08.012.215.221.122.625.940.540.548.5

    Oceania5.04.64.94.74.64.95.06.56.96.97.6

    Africa4.34.96.16.17.610.611.312.920.220.224.3

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.9

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. in 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand)

    Tally0.00.00.00.00.00.00.00.00.00.00.0

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014

    (Metric Tons)

    19921994199619982000200320052008201020122014

    North America126.5109.3119.0105.079.3121.6125.2125.5139.0152.8169.7

    Europe148.2148.7131.1101.0100.2107.6116.2126.6128.6136.8144.7

    Asia & Pacific122.9162.1158.9179.7180.8162.3162.5206.4244.8276.9420.0

    Latin America8.58.632.223.122.824.529.232.934.238.143.7

    Middle East/Africa8.310.914.118.322.831.734.038.860.760.772.85.4%

    Total414.4439.6455.3427.2405.9447.7467.1530.3607.2665.3850.96.9%

    * Amended: Middle East has been carved out from Asia and Pacific (4 Kg. In 1992, 6 in 1994 and 8 in 1996)

    Asia and Pacific includes Oceania (Australia and New Zealand

    Total: 8,992,000 liters

    Total market $19.7 Billion

    The Global Plasma Proteins Market by Region 2014(Source: MRB)

    Albumin_Chart

    North America

    Europe

    Asia & Pacific

    Latin America

    Middle East/Africa

    WORLDWIDE ALBUMIN SALES BY REGION FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES FROM 1992 TO 2014(Metric Tons)

    WORLDWIDE ALBUMIN SALES BY REGION(Percentage of Metric Tons)Total: 850.9 Metric Tons

    Chart3

    6227.2

    100

    26481.8

    60

    3342.7

    Total: 33,575,000 liters

    Total source 36,212,000 liters

    Plasma for Fractionation by Region 2014(Source)

    Population_2014

    World Population 2014 (UN)

    2014

    Middle East/Africa1,13615.7%

    North America3544.9%

    Asia & Pacific4,39060.7%

    South America6178.5%

    Europe74110.2%

    Total7,238100.0%

    Population_2014

    Source: PopulationReference Bureau

    World Population by Region - 2014

    Plasma_Supply_Regions

    3/10/12

    Liters of Plasma (1000 liters)

    RecoveredSourceTotal

    Asia & Pacific1,4616,2277,689

    Middle East/ Africa32210042228

    North America2,09026,48228,5716

    Latin America44260502

    Europe4,4333,3437,775

    Total8,74736,21244,959

    Ratio Recovered to Source PlasmaRatio Recovered to Source Plasma

    RecoveredSourceRecovered+Source

    Asia & Pacific19%81%100%

    Middle East & Africa76%24%100%

    North America7%93%100%

    Latin America88%12%100%

    Europe57%43%100%

    World19%81%100%

    Plasma_Supply_Regions

    Total recovered & source: 44,959,000 liters

    Plasma for Fractionation by Region 2014(Recovered & Source)

    Plasma_Supply_Country

    3/10/12

    20132014

    RecoveredApheresisTotalRecoveredApheresisTotal

    Australia325256581325256581

    China *- 04,9504,950- 05,2005,200

    India352- 0352352- 0352

    Japan402554956402554956

    Hong Kong3053530535

    Korea (Rep)201210411201210411

    Malaysia23- 02323- 023

    New Zealand51- 05151- 051

    Singapore82108210

    Taiwan30- 03030- 030

    Thailand30- 03030- 030

    Other Asia10- 01010- 010

    Sub-total Asia & Pacific1,4615,9777,4391,4616,2277,68917.1%

    Argentina14051451405145

    Brazil140- 0140140- 0140

    Chile15- 01515- 015

    Cuba1001511510015115

    Mexico5- 055- 05

    Uruguay12- 01212- 012

    Venezuela204060204060

    Other Latin America10- 01010- 010

    Sub-total Latin America44260502442605021.1%

    Canada24042432404243

    United States *1,95024,15326,1031,85026,47828,328

    Sub-total North America2,19024,15726,3462,09026,48228,57163.6%

    South Africa *10051051005105

    Iran1409523514095235

    Egypt5- 055- 05

    Morocco15- 01515- 015

    Israel47- 04747- 047

    Other Middle East/Africa15- 01515- 015

    Sub-total Middle East/Africa3221004223221004220.9%

    * 2014 Data