Osp2 sept 2015 OSM/TB
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Transcript of Osp2 sept 2015 OSM/TB
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Open Source Malaria/TB Update
A/Prof Matthew Todd, School of Chemistry, University of Sydney
mattoddchem
http://intermolecular.wordpress.com/
OSP2, Marburg, Aug 31-Sept 3 2015
Matthew Todd
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http://www3.imperial.ac.uk/schisto; http://bit.ly/9azFHv
Open Project #1: Bilharzia2/12
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Completed Open Solution
Details of Route: PLoS NTD 2011, 5(9): e1260 Full Description of Project: Nature Chemistry 2011, 3, 745-748
3/12
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Open Source Malaria 4/12
http://www.thesynapticleap.org/node/343
Landing page:http://opensourcemalaria.org
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OSM Series Summary 5/12
http://openwetware.org/wiki/OpenSourceMalaria:Compound_Series
Series typically not exhausted - Decision points made to move to another.Anyone free to employ OSM infrastructure to explore these series
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Inputs on Data/Visualisation 6/12
With
With Luc Patiny
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Inputs on Strategy 7/12
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Writing 8/12
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OSTB – Series 2 – The Hit9/12
GSK Tres Cantos, J. Overington and M. Marti-Renom, Unpublished 2014
Predicted Targets:
1) O06266 (an epoxide hydrolase)2) A2VJ47 (an epoxide hydrolase ephB)3) P64411 (Heat shock protein 90)4) P96222 (Mtb HTH-type transcriptional regulator Eth)
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Is Open Source Drug Discovery Realistic?10/12
http://www.fda.gov/scienceresearch/specialtopics/criticalpathinitiative/criticalpathopportunitiesreports/ucm077262.htm
100% Obvious 29% Obvious89% Obvious
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Break a Monolithic Structure11/12
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Reconstruct12/12
Nimble, self-assembly encouraged through openness
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26/26
Open AccessContent may be viewed freely without charge to the reader.
Open InnovationProblems are posted openly, solutions can be closed/private.Significant level of ownership of result.
CrowdsourcingA group completes a task by individuals completing small fragments. No requirement for methods/details to be shared.Gain: Person-power
Open SourceAll data and ideas are shared openly (i.e. with everyone), anyone may contribute at any level.All content may be remixed and reused.No consortia, restrictions, embargoes, minimal ownership.Gain: Lack of (unnecessary) duplication