New perspectives and future options for treatment of endotoxemia

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anti equineTNF~monodonal antib~es givento horseffprior t r e a t . s NseaSe ~e~se~freceptorgeneratedantagonists : m ~ S i o ~ with endotoxin si~fiCanflyimproved e~e~ sho~dprovide a treatment ~ effective ag~t abn ~ S~oreand !oweredpl~S~ lactate proStacycfifi al! endoto~ which ~e TLP.siin ~ interleuN~ 6 ~Qncentration~ However,when ~fi-TNFa activate a number of s i g n transductionpat,hways ~h~eng~ the g ease The~ ~ Of~ endomxin le COX (COX 2) ~N ~ ~fi effe~t~ofglu~ oid~ ~ d N S ~ i ~i~; of~s ability,the ~ D ~ g ~S~ade m'ad N~N N i wherea~ activated kJnases p38; ~ K and ERK; Gtuco~orti~oid

Transcript of New perspectives and future options for treatment of endotoxemia

anti equine TNF~monodonal antib~es given to horseffprior t r e a t . s NseaSe ~e~se~freceptorgeneratedantagonists : m ~ S i o ~ with endotoxin si~fiCanfly improved e~e~ sho~dprovide a treatment ~ effective a g ~ t

abn ~ S~ore and !owered pl~S~ lactate proStacycfifi al! endoto~ which ~e TLP.si in ~ interleuN~ 6 ~Qncentration~ However, when ~fi-TNFa activate a number of s i gn transduction pat,hways

~h~eng~ the g

ease The~ ~ Of ~ endomxin le COX (COX 2) ~N ~ ~fi effe~t~ ofglu~ oid~ ~d N S ~ i ~i~; of~s

ability, the ~D~g ~S~ade m'ad N~N N i wherea~ activated kJnases p38; ~ K and ERK; Gtuco~orti~oid