Download - New perspectives and future options for treatment of endotoxemia

Transcript

anti equine TNF~monodonal antib~es given to horseffprior t r e a t . s NseaSe ~e~se~freceptorgeneratedantagonists : m ~ S i o ~ with endotoxin si~fiCanfly improved e~e~ sho~dprovide a treatment ~ effective a g ~ t

abn ~ S~ore and !owered pl~S~ lactate proStacycfifi al! endoto~ which ~e TLP.si in ~ interleuN~ 6 ~Qncentration~ However, when ~fi-TNFa activate a number of s i gn transduction pat,hways

~h~eng~ the g

ease The~ ~ Of ~ endomxin le COX (COX 2) ~N ~ ~fi effe~t~ ofglu~ oid~ ~d N S ~ i ~i~; of~s

ability, the ~D~g ~S~ade m'ad N~N N i wherea~ activated kJnases p38; ~ K and ERK; Gtuco~orti~oid