Mini-Talk 2a The Sister Study
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Mini-Talk 2a The Sister Study Genetics, the environment, their interaction and breast cancer risk How will biomonitoring be used in this long-term study of sisters of women with breast cancer? A special thanks to Dr. Dale Sandler, PI of Sister Study, for sharing her slides and graphics that were used for this mini-talk
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Mini-Talk 2a The Sister Study. Genetics, the environment, their interaction and breast cancer risk How will biomonitoring be used in this long-term study of sisters of women with breast cancer? - PowerPoint PPT Presentation
Transcript of Mini-Talk 2a The Sister Study
Mini-Talk 2a The Sister Study
Genetics, the environment, their interaction and breast cancer risk
How will biomonitoring be used in this long-term study of sisters of women with breast cancer?
A special thanks to Dr. Dale Sandler, PI of Sister Study, for sharing her slides and graphics that were used for this mini-talk
The Sister Studyhttp://www.sisterstudy.org
Following 50,000 sisters of women diagnosed with breast cancer for 10 yrs
Explore linkages between genetics, biology and the environment
Cancer and medical history Diet and exercise Personal care products use Residential exposures / GIS Workplace exposures
The Sister Study -Creating a framework
Create a framework to study current and future hypotheses Be responsive to current public concerns But, plan for the future The hypotheses we may have in 5 to 10
years may be very different than our current ideas of what may affect breast cancer risk.
The Sister Study -Sample collection
Variety of human specimens Blood
Whole blood, serum/plasma Lymphocytes
Urine sample Toenail clippings
House dust swipes
B-D
Alcohol Swab
The Sister Study -Possible future analyses
Hormones (estrogens, prolactin) Growth factors (insulin-like-growth factor)
Dietary factors (vitamin metabolites)
Polymorphisms in variety of genes DNA damage and repair
The Sister Study -Possible future analyses
Environmental exposures Metals (toenails and blood) Phthalates and pesticides (urine) Phenols, pesticides, PCBs, PAHs
(blood / dust swipes) Solvents, pesticides, phytoestrogens,
melatonin metabolites, brominated and chlorinated chemicals (blood)
The Sister Study -Working with CDC’s NCEH
NIEHS is working with CDC’s National Center for Environmental Health (NCEH)
The types of biomonitoring and genetic analysis possible in 5 to10 years will probably be much greater than what is currently available
Long-term storage of samples for future analysis
The Sister Study-Storage of samples
Twelve -20o C freezersSix -80o C freezers Each freezer holds
56,700 vials
The Sister Study-Storage of samples
36 Liquid Nitrogen TanksEach holds
275,184 “straw” samples
