Maternal Stress & Fetal Programming
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Transcript of Maternal Stress & Fetal Programming
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Maternal Stress & Fetal Programming
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Prenatal Stress & Programming of the Brain Prenatal stress (animal model)
Hippocampus Site of learning & memory formation Stress down-regulates glucocorticoid receptors Loss of negative feedback; overactive HPA axis
Amygdala Site of anxiety and fear Stress up-regulates glucocorticoid receptors Accentuated positive feedback; overactive HPA
axisWelberg LAM, Seckl JR. Prenatal stress, glucocorticoids and the programming of the brain.J Neuroendocrinol 2001;13:113-28.
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Allostasis: Maintain Stability through Change
McEwen BS. Protective and damaging effects of stress mediators. N Eng J Med. 1998;338:171-9.
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Allostastic Load:Wear and Tear from Chronic Stress
McEwen BS. Protective and damaging effects of stress mediators. N Eng J Med. 1998;338:171-9.
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Stressed vs. Stressed Out Stressed
Increased cardiac output
Increased available glucose
Enhanced immune functions
Growth of neurons in hippocampus & prefrontal cortex
Stressed Out Hypertension & cardiovascular diseases
Glucose intolerance & insulin resistance
Infection & inflammation
Atrophy & death of neurons in hippocampus & prefrontal cortex
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Rethinking Preterm Birth
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Racial & Ethnic DisparitiesVery Preterm Births < 32 Weeks
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1.63
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Percent of Live Singleton Births
Year 2010 Goal
NCHS 2006
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Allostasis & Allostatic Load
McEwen BS, Lasley EN. The end of stress: As we know it. Washington DC: John Henry Press. 2002
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Rethinking Preterm Birth
Vulnerability to preterm delivery may be traced to not only exposure to stress & infection during pregnancy, but host response to stress & infection (e.g. stress reactivity & inflammatory dysregulation) patterned over the life course (early programming & cumulative allostatic load)
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Life Course Perspective
Lu MC, Halfon N. Racial and ethnic disparities in birth outcomes: a life-course perspective.Matern Child Health J. 2003;7:13-30.
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Childhood conditions and persistent bacterial vaginosis Cammack et al* found:
Associations of childhood sexual assault, and lack of parental home ownership to be associated with bacterial vaginosis
No effect of education after controlling for the above.
BV has a 2x increased risk of preterm birth and even higher risk for early preterm birth.
Am J Obstet Gynecol 2011:204:431
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Barker HypothesisBirth Weight and Insulin Resistance Syndrome
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<5.5 5.6-6.5 6.6-7.5 7.6-8.5 8.6-9.5 >9.5Birthweight (lbs)
Odds ratio adjusted for BMI
Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K, Clark PMS. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (Syndrome X): Relation to reduced fetal growth. Diabetologia 1993;36:62-67.
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Preterm Birth &Maternal Ischemic Heart Disease
Kaplan-Meier plots of cumulative probability of survival without admission or death from ischemic heart disease after first pregnancy in relation to preterm birth
Smith et al Lancet 2001;357:2002-06
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Eggs and Sperm are created in the middle of pregnancy (18-20 weeks)
Means that conditions of the grandmother during her pregnancy affects the earliest “elements” of her grandchildren.
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Life Course Perspective
Lu MC, Halfon N. Racial and ethnic disparities in birth outcomes: a life-course perspective.Matern Child Health J. 2003;7:13-30.