Managing Hereditary Angioedema
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Transcript of Managing Hereditary Angioedema
Managing Hereditary Angioedema
Setting the StageBurden of Disease in HAE
Burden of Disease in HAE (cont)
C1 Esterase Inhibitor for Treatment of Laryngeal Attacks in HAE
Other Therapies Approved For On-Demand Treatment of HAE Attacks
Ecallantide Efficacy
Icatibant FAST-3 Trials
Icatibant Reinjection Rates
C1 Inhibitor Use in Children
C1 Inhibitor Use in Children (cont)
C1 Inhibitor Use in Children for Short-term Prophylaxis
MacGinnitie et al Study of Ecallantide Treatment for Pediatric
HAE
Treatment Outcomes With Ecallantide vs Placebo
C1 Inhibitor Dose-escalation Study
C1 Inhibitor Dose-escalation Study (cont)
The Successes in 14 Patients
Treatment Failures
Impact of HAE Prophylaxis on QoL
Effects of C1 Inhibitor Prophylaxis vs On-demand Therapy on QoL
SF-36 Norm-based Domain and Component Summary Scores
Recommendations for Managing HAE
Recommendations for Managing HAE (cont)
Abbreviations
References
References (cont)
References (cont)
References (cont)