jnm498 thismonthinjnm 11.jnm.snmjournals.org/content/49/8/11A.full.pdf · Overview of SPECT/CT:...
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‘‘Amphibian cars’’ for molecular imaging: Boerman and Oyen look at the challenges surrounding development of hybrid PET/MRI scanners and previews an article in this issue of JNM introducing a molecular probe that pro- vides a signal in both modalities. . . Page 1213 Single-session PET/CT staging mammog- raphy: Heusner and colleagues compare the diagnostic accuracy of an all-in-one protocol of whole-body 18 F-FDG PET/CT and inte- grated 18 F-FDG PET/CT mammography with that of a multimodality algorithm for initial breast cancer staging.......... Page 1215 Breath-hold PET/CT in lung cancer: Kawano and colleagues describe the ad- vantages of breath-hold over free-breathing PET/CT in providing more precise measure- ment of maximum SUVs.... Page 1223 Optimal imaging for paraganglioma: Koopmans and colleagues evaluate the diag- nostic accuracies of 111 In-octreotide somato- statin receptor scintigraphy, 123 I-MIBG scintigraphy, and morphologic imaging in patients with highly suspected head and neck paragangliomas.............. Page 1232 Gene modulation of 18 F-FDG kinetics: Strauss and colleagues use PET imaging and histopathologic results to assess the effects of angiogenesis-related gene expression on 18 F- FDG kinetics in patients with primary colorectal tumors. ......... Page 1238 11 C-choline PET in hepatocellular cancer: Yamamoto and colleagues explore the poten- tial utility of 11 C-choline PET as a complement to 18 F-FDG PET in the detection of hepatocel- lular carcinoma lesions. ........ Page 1245 11 C-(R)-PK11195 imaging in AD: Tomasi and colleagues report on a reference region model for estimating the binding potential of a PET radiotracer that shows increased microglial activity and decreased vascular binding in individuals with Alzheimer’s disease..................... Page 1249 Opioidergic system and rewards: Schreck- enberger and colleagues use 18 F-DPN to investigate the neurobiologic correlates of reward dependence and discuss the implica- tions of these findings for predicting predis- position to addictive behavior. . . Page 1257 Voxel-based diagnosis of Alzheimer’s dis- ease: Mikhno and colleagues explore the utility of 11 C-PIB PET imaging of amyloid-b accumulation in discriminating healthy in- dividuals from those with Alzheimer’s dis- ease. ...................... Page 1262 Novel transporter radioligand: Arakawa and colleagues report on several methods for quantification of (S,S)- 18 F-FMeNER-D 2, a PET imaging agent with promise for direct estimation of norepinephrine transporter occu- pancy by antidepressants........ Page 1270 Reversal of vascular 18 F-FDG uptake: Lee and colleagues evaluate serial changes in vascular 18 F-FDG uptake in response to lifestyle interventions and discuss the potential use of this technique in athero- genic risk reduction........ Page 1277 Gated SPECT in atrial fibrillation: Scia- gra ` and colleagues examine differences in myocardial perfusion between simultane- ously acquired gated and nongated SPECT data in patients with atrial fibrillation and provide recommendations for optimal as- sessment. ................. Page 1283 Viability in ventricular aneurysms: Zhang and colleagues describe long-term benefits of SPECT and PET in assessing the viability of aneurysmal myocardium in patients with ischemic cardiomyopathy and compare short-term results in those undergoing re- vascularization or revascularization plus aneurysmectomy . ............ Page 1288 THIS MONTH IN JNM 11A by on June 21, 2020. For personal use only. jnm.snmjournals.org Downloaded from
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‘‘Amphibian cars’’ for molecular imaging:Boerman and Oyen look at the challengessurrounding development of hybrid PET/MRIscanners and previews an article in this issue ofJNM introducing a molecular probe that pro-vides a signal in both modalities. . . Page 1213
Single-session PET/CT staging mammog-raphy: Heusner and colleagues compare thediagnostic accuracy of an all-in-one protocolof whole-body 18F-FDG PET/CT and inte-grated 18F-FDG PET/CT mammography withthat of a multimodality algorithm for initialbreast cancer staging. . . . . . . . . . Page 1215
Breath-hold PET/CT in lung cancer:Kawano and colleagues describe the ad-vantages of breath-hold over free-breathingPET/CT in providing more precise measure-ment of maximum SUVs. . . . Page 1223
Optimal imaging for paraganglioma:Koopmans and colleagues evaluate the diag-nostic accuracies of 111In-octreotide somato-statin receptor scintigraphy, 123I-MIBGscintigraphy, and morphologic imaging inpatients with highly suspected head and neckparagangliomas. . . . . . . . . . . . . . Page 1232
Gene modulation of 18F-FDG kinetics:Strauss and colleagues use PET imaging andhistopathologic results to assess the effects ofangiogenesis-related gene expression on 18F-FDG kinetics in patients with primarycolorectal tumors. . . . . . . . . . Page 1238
11C-choline PET in hepatocellular cancer:Yamamoto and colleagues explore the poten-tial utility of 11C-choline PETas a complementto 18F-FDG PET in the detection of hepatocel-lular carcinoma lesions. . . . . . . . . Page 1245
11C-(R)-PK11195 imaging in AD: Tomasiand colleagues report on a reference regionmodel for estimating the binding potential ofa PET radiotracer that shows increasedmicroglial activity and decreased vascularbinding in individuals with Alzheimer’sdisease. . . . . . . . . . . . . . . . . . . . . Page 1249
Opioidergic system and rewards: Schreck-enberger and colleagues use 18F-DPN toinvestigate the neurobiologic correlates ofreward dependence and discuss the implica-tions of these findings for predicting predis-position to addictive behavior. . . Page 1257
Voxel-based diagnosis of Alzheimer’s dis-ease: Mikhno and colleagues explore theutility of 11C-PIB PET imaging of amyloid-baccumulation in discriminating healthy in-dividuals from those with Alzheimer’s dis-ease. . . . . . . . . . . . . . . . . . . . . . . Page 1262
Novel transporter radioligand: Arakawa andcolleagues report on several methods forquantification of (S,S)-18F-FMeNER-D2, aPET imaging agent with promise for directestimation of norepinephrine transporter occu-pancy by antidepressants. . . . . . . . Page 1270
Reversal of vascular 18F-FDG uptake:Lee and colleagues evaluate serial changesin vascular 18F-FDG uptake in response tolifestyle interventions and discuss thepotential use of this technique in athero-genic risk reduction. . . . . . . . Page 1277
Gated SPECT in atrial fibrillation: Scia-gra and colleagues examine differences inmyocardial perfusion between simultane-ously acquired gated and nongated SPECTdata in patients with atrial fibrillation andprovide recommendations for optimal as-sessment. . . . . . . . . . . . . . . . . . Page 1283
Viability in ventricular aneurysms: Zhangand colleagues describe long-term benefits ofSPECT and PET in assessing the viability ofaneurysmal myocardium in patients withischemic cardiomyopathy and compareshort-term results in those undergoing re-vascularization or revascularization plusaneurysmectomy. . . . . . . . . . . . . Page 1288
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Human biodistribution of 99mTc-N-DBODC: Cittanti and colleagues assess thesafety profile and biodistribution of a newmyocardial perfusion tracer that promises toprovide early and high-quality SPECT imagesof the left ventricle. . . . . . . . . . . . Page 1299
Overview of SPECT/CT: Buck and col-leagues offer an educational review of thecurrent status and future prospects ofhybrid SPECT/CT in cardiac, neurologic,and oncologic applications. . . Page 1305
Diabetes and myocardial glucose use:Shoghi and colleagues investigate myocar-dial glucose metabolism in a rodent modelof type 2 diabetes and validate PETmeasurements of glucose uptake againstgene and protein expression of glucosetransporters. . . . . . . . . . . . . . . . Page 1320
Functional P-gp activity at the BBB:Bankstahl and colleagues use (R)-11C-verapamil PET and tariquidar, a new-gen-eration P-glucoprotein modulator, to studyfunctional activity at the blood–brain barrierin rats. . . . . . . . . . . . . . . . . . . . . Page 1328
Pharmacokinetics of 99mTc(N)-DBODC(5):Bolzati and colleagues elucidate the mechanismsof distribution, retention, and elimination of apromising myocardial imaging agent and de-
scribe the potential for extension to tumorimaging and noninvasive multidrug resistancestudies. . . . . . . . . . . . . . . . . . . . . . . .Page 1336
Imaging PtdE availability: Zhao and col-leagues report on the development of 99mTc-duramycin as a novel molecular probe forimaging phosphatidylethanolamine, a majorphospholipid externalized to the surfaceof apoptotic cells and accessible in necroticcells. . . . . . . . . . . . . . . . . . . . . . . Page 1345
Cytotoxicity of 111In-DTPA-hEGF: Caiand colleagues investigate the relationshipsamong human epidermal growth factor ex-pression, DNA damage, and cytotoxicity incells exposed to an Auger electron–emit-ting radiopharmaceutical. . . . Page 1353
PET/MRI in pancreatic cancer: vonForstner and colleagues compare uptake of18F-FDG, 18F-FLT, and 18F-FEC in humanpancreatic tumor cell lines in mice andcorrelate tumor uptake with gene expressionof membrane transporters and rate-limitingenzymes. . . . . . . . . . . . . . . . . . Page 1362
Bifunctional PET/MRI probe: Lee andcolleagues detail the development of a
bifunctional iron oxide nanoparticle probefor PET and MRI scans of tumor integrinavb3 expression. . . . . . . . . . Page 1371
99mTc-HMPAO in RA: Bennink and col-leagues assess the biodistribution and radia-tion dosimetry of 99mTc-HMPAO–labeledmonocytes in adult patients with rheumatoidarthritis and describe the potential applica-tions in noninvasive monitoring of therapyand disease progression. . . . . . . . Page 1380
18F-FDG in colorectal tumor cells:Sharma and Smith look at therapy-inducedchanges in tracer incorporation at thetumor cell level in response to conven-tional and novel chemotherapy agents.. . . . . . . . . . . . . . . . . . . . . . Page 1386
Case against radioiodine ablation: Hayand colleagues take issue with widely usedpostoperative radioiodine remnant ablationas adjuvant therapy in patients with well-differentiated thyroid carcinoma and out-line reasons for suggesting that ablation isoften the wrong choice. . . . . Page 1395
O N T H E C O V E R
The maximum SUV of free-breathing PET should not be accepted asaccurate, especially in the lower lung and for small pulmonary lesions.In this patient, blurring of 18F-FDG accumulation was more apparentin fusion free-breathing PET/CT (top) than in fusion breath-holdPET/CT (bottom). Breath-hold imaging realizes a complete matchbetween CT and PET and is thus recommended as part of the standardprotocol for lung cancer.
See page 1229.
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