Homeopathy and immuno-allergic inflammation in … · Asthma is not an innocuous functional state...

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Homeopathy and immuno-allergic

inflammation in asthmatic children:

Assessment based on exhaled breath

temperature

Slavi Filtchev

Todor A. Popov

BULGARIA


Definition of asthma (GINA 1995):

Chronic inflammatory disease of the respiratory tract

Infiltration with mast cells, eosinophils, and lymphocytes

Recurrent attacks of wheezing, coughing and shortness of breath

Variable narrowing of airways that is at least partially reversible

Bronchial hyper-reactivity

Evolution of the concept


Rubor

Calor

Tumor

Dolor

Functio laesa

Characteristic features of inflammation

Pathophysiology of asthma

Key words: inflammation, bronchial hyper-reactivity, airway remodeling

1970s 1980s 1990s Currently

Bronchial spasm Bronchial spasm

+ Inflammation

Bronchial spasm

+ Inflammation

+ Remodeling

CHEST 2013; 144 (3): 1026–1032.

Eosinophilic T-cell

Th - 2

HE-5 / IL-13

Th17

Dendritic cells

Heterogenesis

Phenotypes

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Inflammatory phenotypes based on analysis of the sputum

EOS Neut Mixed Pauci Healthy

J Simpson et al., Respirology, 2006


Risk factors (for the development of asthma)

INFLAMMATION

Hyper-reactivity of the airways

Obstruction

of the airways

Risk factors(for exacerbations) Symptoms

Mechanisms underlying the definition of asthma


Exhaled Breath Temperature (EBT): BASIC

CONCEPT

Temperature taking is universally used as a

diagnostic and prognostic tool for infectious or other

diseases. Usually, it is measured at the traditional

body sites and provides estimates for core

temperature with a reasonable degree of

approximation.


• The deep structures of the lungs usually have a temperature which is

representative of the center of the body and which is determined by

the blood circulating in the bloodstream of the alveoli.

• The blood supply to the upper airways is separated from the left side

of the heart. Any process that can change the circulation in the walls

of the airways can affect the temperature of the exhaled air, i.e. EBT.

Popov TA et al., IEEE Sensors j., 2010

Exhaled Breath Temperature (EBT): BASIC CONCEPT



Popov TA, Dunev S, Kralimarkova TZ Kraeva S,

DuBuske LM.

Evaluation of a simple, potentially individual

device for exhaled breath temperature

measurement.

Respiratory Medicine, 2007; 101 (10):

2044-2050.

Conceptual diagram of the portable

EBT measuring device

Popov TA et al., IEEE Sensors J. [in press]



Development of an Individual Device for Exhaled Breath

Temperature Measurement

Generation 1 Generation 2 Generation 3 Generation 4


Breath Analysis Summit 2011 - International Conference on Breath Research, Parma, 11-14 September

2011


Goal of clinical observation

Evaluation of the effectiveness of the combined

therapeutic approach, homeopathic & allopathic, in

the treatment of childhood asthma with a new non-

invasive indicator: exhaled breath temperature (EBT).


Taking the temperature of the exhaled breath


Patients

79 children (aged 7 to 17 years) with persistent moderate or

severe asthma, indicated for treatment with an inhaled

corticosteroid (ICS)

• "Homeopathic" group (ICS + homeopathic therapy) –

42 children

• "Allopathic" group (ISC only) – 37 children

• Control group – healthy children without active

pulmonary infection or asthma – 22 children


Methods

1. Clinical evaluation of asthma

2. At the beginning and after three months of

treatment:

- lung function (spirometry);

exhaled breath temperature (EBT)

(X-halo, Delmedica Investments, Singapore).

Asthma is not an innocuous functional state

The Melbourne Asthma Study*

479 children with an asthma, tracked since 1964

Probability for a chronic obstructive pulmonary disease at the

age of 50:

- Mild episodic asthma - equivalent to the healthy population

- Moderate asthma - 10 х

- Severe asthma - 32 х

* Gross N.: Do Asthmatic Children Grow Into Adults With

COPD? Medscape Pulmonary Medicine, 2014


Asthma treatment and homeopathy

Asthma is a chronic disease which, if treated

incorrectly, can lead to disability.

Asthma treatment should be carried out in

accordance with medical standards and

consensus.

Homeopathic treatment does not preclude the

conventional treatment.


Failures in the treatment of asthma are due to

the inability to use the right combination of the

homeopathic method and the conventional

method.

The strength of homeopathy is in prevention.

Asthma treatment and homeopathy


Similimum for the

pathophysiology of asthma?

Asthma phenotypes?



from a homeopathic perspective

Episodic and reversible bronchial obstruction (Psora)

Bronchial hyper-reactivity towards several stimuli

(Tuberculinisme)

Remedies for spasm, edema and hypersecretion


Infiltration of the bronchial mucosa with

immunocompetent cells (Psora)

Hypertrophy and hyperplasia of the smooth muscles

of the bronchi (Sycosis)

Hyperplasia of the mucus glands (Sycosis)

Thickening of the basement membrane (Sycosis)

Remedies for the inflammatory immune response




• Connective tissue deposition (Sycosis)

• Epithelial desquamation (Luese)

• Neovascularization (Luese)

Remedies for airway remodeling




Remedies for allergic inflammation

For mediators of the immunoallergic

domino effect:

Histaminum

Poumon histamine

Apis mellifica


For immunocompetent cells:

• Tuberculinum, Aviaire – lymphocyte

subpopulations, cellular immunity

• Bryonia alba - structural similarity with

corticosteroids

• Sulfur iodatum -neutrophil inflammation

Remedies for allergic inflammation


For hypertrophy, hyperplasia, myofibroblasts and

epithelium:

Thuya occidentalis

Natrum sulfuricum

Causticum

Graphites

Tuberculinum residuum

Remedies for bronchial remodeling


For the neo-angiogenesis, subepithelial fibrosis,

defragmentation and alteration of cartilage

integrity:

Fluoricum acidum

Muriaticum acidum

Calcarea fluorica

Remedies for bronchial remodeling


8 year old boy

• Atopic dermatitis since infancy

• Pollen-induced rhino-conjunctivitis

• Allergies to several allergens

• Frequent and severe attacks, but with a

fast response to treatment

• Eosinophilia

• EBT 35.7 0 C

• Obese, loves food

• Positive attitude towards life

• Subject to diarrhea

Clinical case 1


Bronchial obstruction

Clinical case 1


Spirometry data - bronchial obstruction

Clinical case 1


Treatment

• Sulfur

• Poumon histamine

• Apis mellifica

• Thuya occidentalis

• Graphites

Clinical case 1


After treatment

• Full remission

• EBT 32.8 0 C

Clinical case 1


Clinical case 1


13 year old girl

• Frequent respiratory infections and pneumonia with an

obstructive syndrome

• Asthma attacks during infections

• Prolonged exacerbations, incomplete remissions

• Good response to treatment with antibiotics

• Constant "wet" cough

• EBT 33.8 0 C

• Marfan syndrome appearance

• Fatigue

• Unstable mood

Clinical case 2


Bronchial obstruction, fibrosis

Clinical case 2


A combined obstructive restrictive disorder

Clinical case 2


Treatment

• Tuberculinum

• Silicea

• Natrum sulfuricum

• Calcarea fluorica

Clinical case 2


After treatment

• Decrease in the frequency and severity of

attacks

• EBT 32.9 0 C

Clinical case 2


Clinical case 2


Respiratory function prior to treatment

65.9 66.1

Homeo + ICS ICS

%

N

FEV1 MMEF 25-75% FVC

Control

84.2 96.585.8 89.7* p < 0.05


Initial EBT data EBT ˚C

Homeo + ICS ICS Control

* p < 0.05


Respiratory function after treatment

% N

FEV1 MMEF 25-75% FVC

Homeo + ICS ICS Control

* *

Exhaled Breath Temperature before and after treatment

34,51 ± 0,96 32,67 ± 0,84***

Homeo + ICS

mean ± sd:

before treatment

after treatment

*** p < 0.0001

25

27

29

31

33

35

37

˚C



34.83 ± 0.6234.37 ± 0.88*

mean ± sd:

before

treatment

after treatment

* p = 0.04

ICS

˚C


Homeo + ICS

ICS

before

treatment

after treatment

N EBT = 32.9˚C



Exhaled Breath Temperature before and after treatment in comparison

with the "standard"

Homeo + ICS ICS

before

treatment

after treatment

N EBT = 32.9˚C



Conclusion

The combination of the homeopathic method

and the conventional method results in

control of immuno-allergic inflammation

(determined by EBT) in children with asthma

at a higher level than that resulting from the

conventional method alone.


Homeopathic treatment must include

treatment targeting inflammation and

airway remodeling.

Conclusion


Thank you for your attention

Homeopathy and immuno-allergic inflammation in … · Asthma is not an innocuous functional state...

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