Immuno Stimulant
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Transcript of Immuno Stimulant
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DEFINITION ;
An agent that produces a
temporary increase of the
functional activity or
efficiency of a organism or any
of its parts.
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Definition;
Also known as
immunostimulators.
Immunostimulants are the
substances that stimulate the
immune system by inducing
activation or increasing activityof any of its components.
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A number of disorders such as Autoimmune
diseases , cancer, & viral infections can be
treated with immunostimulant drugs.
They may affect innate as well as adaptiveimmunity.
These may work on cellular or humoral immune
system or both.
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BIOLOGICAL RESPONSE MODIFIERS or
IMMUNOMODULATORS
Because
Variable effects in different conditions & ondifferent components of immune system.
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SPECIFIC IMMUNOSTIMULANTS;
Provide antigenic specificity in
immune response.
NONSPECIFIC IMMUNOSTIMULANTS;
Stimulate components of the
immune system without
antigenic specificity.
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It is an attenuated live culture of calmette-guerin strain of bacillus MYCOBACTERIUMBOVIS.
Active constituent is muramyl dipeptide.
Its action is Nonspecific
Stimulates T-cells & NK cells
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USES;
Treatment of urinary bladder
cancer
ADR;
Chills, fever, malaise [feeling of
discomfort], hypersensitivity
reactions, & shock.
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It is actually an anthelmintic drug.
Also stimulates T-cells, B-cells, monocyte, &
macrophage activity.
levamisole + 5-fluorouracil
Improve survival of patients suffering with
colorectal cancer [colon or rectum].
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Also used in patients with slow spreading
Vitiligo [depigmentation or discoloration of
skin].
ADR;Flu-like symptoms, allergic
manifestations, nausea, &
muscle pain.
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This drug is available for restricted use i.e
to treat erythema nodosum leprosum &
multiple myeloma because of its
immunomodulatory & anti-inflammatoryeffects.
It decreases TNF- levels in blood &
produces angiogenic effects.
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Interferons;
IFN-, IFN-1a & 1b, IFN-
Interleukin-2;Aldesleukin, opreleukin
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Group of peptide hormones synthesised by
thymus gland.
It regulates T-cell maturation &stimulates
IFNs & IL-2 production.Treatment of hepatitis.
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Nonspecific immunomodulator.
Treatment of urinary bladder cancer.
ISOPRINOSINEIt increases natural killer cell cytotoxicity &
activity of T-cells ,monocytes.
USES; common cold, influenza, herpes,
viral encephalitis, delaying the onset ofAIDS in patients infected with HIV.
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?TIME FOR DOUBTS
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THANK YOUPREPARED BY,N.NANTHINI