Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory

Photo image area measures 2” H x 6.93” W and can be masked by a collage strip of one, two or three images.

The photo image area is located 3.19” from left and 3.81” from top of page.

Each image used in collage should be reduced or cropped to a maximum of 2” high, stroked with a 1.5 pt white frame and positioned edge-to-edge with accompanying images.

April 12, 2023

EPA Data from the Office of Research and DevelopmentStephen W. EdwardsEdwards.stephen@epa.gov

This talk does not necessarily reflect the views of the Environmental Protection Agency.

Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division

One Stop Shopping for EPA Data

http://epa.gov/datafinder/

Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division

Computational Toxicology Data

• Aggregated Computational Toxicology Resource (ACToR)–http://www.epa.gov/actor/

• Distributed Structure-Searchable Toxicity (DSSTox) Database–http://actor.epa.gov/actor/faces/DSSTox/Home.jsp

• Exposure foreCaster (ExpoCastTM) Database–http://www.epa.gov/ncct/expocast/

• Toxicity foreCaster (ToxCastTM) Database–http://www.epa.gov/ncct/toxcast/

• Toxicity Reference Database (ToxRefDB)–http://actor.epa.gov/toxrefdb/faces/Home.jsp

• Tox21 Collaboration (NIH, FDA)–http://www.epa.gov/ncct/Tox21/

http://epa.gov/ncct/index.html

Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division

Exposure Data

• Consolidated Human Activity Database - CHAD–http://www.epa.gov/heasd/chad.html

• Consumer Product Chemical Profiles Database – CPCPDB–Coming soon to ACToR: http://www.epa.gov/actor/

• ExpoCast–http://www.epa.gov/ncct/expocast/

• Stochastic Human Exposure and Dose Simulation Model (SHEDS)– http://www.epa.gov/heasd/research/sheds.html

Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division

DSS Tox

ToxCast

ExpoCastSHEDS

Virtual Tissue,Biomarker, andAdverse Outcome Pathway Knowledgebases

ToxRefDBWikiLIMS

Tox21 Data Housed at EPA

Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division

Toxicological Data Shared via CEBS (NIEHS)

Proteomics Core2D Gel

Mass Spec

Metabolomics /Anal Chem Core

NMRMass Spec

ToxicoGenomics CoreMicroarray

qPCRSequencing

WikiLIMS

Many different investigators

Experimental DesignHuman, Animal, Culture

Treatment Schedule Stressor (Compound)

Assay descriptionsTimeline

Animal CareCell Culture Conditions

Sample Preparation

Laboratory/Field DataHistopathology

Clinical ChemistryIn Life Observations

Behavioral ObsDevelopmental Obs

Necropsy ObsExposure biomarkers

Exit

http://cebs.niehs.nih.gov/