Evolving roles of universities in knowledge integration

and economic growth

Seoul, Korea Nov 6, 2013

Evolving roles of universities

in knowledge integration and economic growth

Seoul, Korea Nov 6, 2013

Evolving roles of universities in knowledge integration

and economic growth

Seoul, Korea Nov 6, 2013

• Academic Community • Start-up Community

Academia and the Problems of Society

Academia Society

Problems*

• Energy

• Pollution

• Water

• Poverty

• Disease

• Aging

• Global Warming

• War

• Women’s rights

• Intolerance

*Wicked problems

Agriculture

Immunology Metabolism

Microbiology

Academic knowledge is fragmented

Economics Chemical

engineering

Cell biology

Neurology

Ecology

Surgery

Stem cell biology

Molecular biology

Political science

Need to integrate across academic

boundaries to solve global

problems

How do we aggregate and integrate academic

knowledge to solve “wicked” problems?

CITRIS (UCB, UCD, UCM, UCSC) Center for Information Technology Research in the Interest of Society

QB3 is one of the Four California Institutes for

Science and Innovation created by the State to

integrate across interfaces

CAL-(IT)2 (UCSD, UCI) Institute for Telecommunications and

Information Technology

QB3 (UCB, UCSC, UCSF)

California Institute for Quantitative Bioscience

CNSI (UCLA,UCSB) California Nanosystems Institute

Integrating Academic Knowledge

The Wicked Problems

• QB3 is a scientific network that integrates the research efforts of its three campuses

Public funds

QB3 Labs

Research Education

QB3 and the Integration of Knowledge

Academia Society

Problems*

• Energy

• Pollution

• Water

• Poverty

• Disease

• Aging

• Global Warming

• War

• Women’s rights

• Intolerance

*Wicked problems

Economics Chemical

engineering

Agriculture

Cell biology

Immunology Metabolism

Neurology

Microbiology

Ecology

Surgery

Stem cell biology

Molecular biology

Political science

QB3 and the Integration of Knowledge

Academia Society

Problems*

• Energy

• Pollution

• Water

• Poverty

• Disease

• Aging

• Global Warming

• War

• Women’s rights

• Intolerance

*Wicked problems

Economics Chemical

engineering

Agriculture

Cell biology

Immunology Metabolism

Neurology

Microbiology

Ecology

Surgery

Stem cell biology

Molecular biology

Political science

$500M

QB3 and the Integration of Knowledge

Academia Society

Problems*

• Energy

• Pollution

• Water

• Poverty

• Disease

• Aging

• Global Warming

• War

• Women’s rights

• Intolerance

Rejuvenation Therapies

Consortium

Economics Chemical

engineering

Agriculture

Cell biology

Immunology Metabolism

Neurology

Microbiology

Ecology

Surgery

Stem cell biology

Molecular biology

Political science

Age Related Disease

The QB3 Rejuvenation Therapies Consortium

Stem Cells Chronic

inflammation

Metabolic

disorders Neuro-

endocrinology

Vasculature

System

Exercise

Tissue Repair

Post-operative

Cognitive

disorder

Cell Repair

Systems Biology

Human

Genetics

Interventions

The QB3 Rejuvenation Therapies Consortium

Stem Cells Chronic

inflammation

Metabolic

disorders Neuro-

endocrinology

Vasculature

System

Exercise

Tissue Repair

Post-operative

Cognitive

disorder

Cell Repair

Systems Biology

Human

Genetics

Interventions

Rejuvenation by mouse parabiosis

• Blood from young mouse rejuvenates muscle, liver, skin and hippocampus of old mouse by restoring replicative capacity to progenitor cells

Rejuvenation by Removing Senescent Cells

• Delete p16 expression (+AP) in progeria mouse; inhibit aging.

HMGB1 + ?

Fracture

Postop Cognitive Decline

Cytokine release

Glial activation

LTP disruption Bone Surgery

Experimentally Induced Cognitive Decline

TNF-α

Neuroinflammation

Hippocampus

Aging trigger Aging response

Lose Quality Control

•DNA, protein & organelle repair

•Tissue remodeling (innate

immunity)

•Initiate reproductive phase

Accelerate Degradative Paths

•Humans- senescent stem cells &

chronic inflammation

•C. elegans – somatic cell death

Consortium View

Modulators

•Wounds, infection, obesity

•Vascular leak

•Diet & Exercise

•Hypothalamic activity

•Blood borne signals

Grand Challenge: Human trials of rejuvenation therapies in five years

Integrating Academic Knowledge

The Wicked Problems

• QB3 is a scientific network that integrates the research efforts of its three campuses

Public funds

QB3 Labs

Research Education

Society problems

Private sector

Public funds

Existing Companies

New Companies

QB3 Labs

Research Education

QB3 Innolab

The Wicked Problems

Creating a Bio-economy

• Discard old models of partnership

• Network industry and academic scientists for society benefit

Private sector

Public funds

Existing Companies QB3 Labs

Research Education

QB3 Innolab

The Wicked Problems

Creating a Bio-economy

Public funds

New Companies

QB3 Labs

Research Education

QB3 Innolab

The Wicked Problems

Creating a Bio-economy

Tools Start-up in a Box

Support in incorporating, launching and SBIR funding

InnoLab Start-up Program

Goal: best biotech start-up community in America

Creating a Bio-economy

140 companies

incorporated in 2 years

Tools Start-up in a Box

Community Workspace

Low cost, high quality lab space near university

Support in incorporating, launching and SBIR funding

InnoLab Start-up Program

Goal: best biotech start-up community in America

Creating a Bio-economy

140 companies

incorporated in 2 years

62 present tenants, 15 graduates,

400 jobs, $2.5M/year/

company,

Hewlett Packard Garage

Start-up in a Box

Community Workspace

Low cost, high quality lab space near university

Support in incorporating, launching and SBIR funding

InnoLab Start-up Program

Goal: best biotech start-up community in America

Creating a Bio-economy

140 companies

incorporated in 2 years

62 present tenants, 15 graduates,

400 jobs, $2.5M/year/

company,

QB3@953: new 24,000sq ft incubator

Tools

Start-up in a Box

Community Workspace

Low cost, high quality lab space near university

Support in incorporating, launching and SBIR funding

InnoLab Start-up Program

Goal: best biotech start-up community in America

Creating a Bio-economy

140 companies

incorporated in 2 years

62 present tenants, 15 graduates,

400 jobs, $2.5M/year/

company,

QB3@953: new 24,000sq ft innovation workspace

Tools

QB3@953

Tools Start-up in a Box

Community Workspace

Mission Bay Capital

Seed funding for QB3 equity

Low cost, high quality lab space near university

Support in incorporating, launching and SBIR funding

InnoLab Start-up Program

Goal: best biotech start-up community in America

Creating a Bio-economy

140 companies

incorporated in 2 years

62 present tenants, 15 graduates,

expanding to ~100,

400 jobs, $2.5M/year/

company,

$11.3M from LPs, 11 companies,

prestigious advisory board

Tools Start-up in a Box

Community Workspace

Mission Bay Capital

Seed funding for QB3 equity

Low cost, high quality lab space near university

Support in incorporating, launching and SBIR funding

InnoLab Start-up Program

Goal: best biotech start-up community in America

Creating a Bio-economy

140 companies

incorporated in 2 years

62 present tenants, 15 graduates,

expanding to ~100,

400 jobs, $2.5M/year/

company,

$11.3M from LPs, 11 companies,

prestigious advisory board

Luke Evnin, PhD

Managing Director

MPM Capital

Ralph (Chris) Christoffersen, PhD

Partner

Morgenthaler Ventures

Brook Byers

Partner

Kleiner, Perkins, Caufield & Byers

Brian Atwood

Managing Partner

Versant Ventures

John Wadsworth, Jr.

Managing Director

Manitou Ventures

Fred Cohen, M.D., Ph.D.

General Partner TPG Ventures

and Professor, UCSF

Bill Ericson

Partner

MDV

Advisory Board

Tools Start-up in a Box

Community Workspace

Mission Bay Capital

Seed funding for QB3 equity

Low cost, high quality lab space near university

Support in incorporating, launching and SBIR funding

Collaborative

Start-ups

Industry co-investors

Creating a Bio-economy

140 companies

incorporated in 2 years

62 present tenants, 15 graduates,

expanding to ~100,

400 jobs, $2.5M/year/

company,

$11.3M from LPs, 11 companies,

prestigious advisory board

Roche, Bayer, J&J, Novartis

InnoLab Start-up Program

Goal: best biotech start-up community in America

Evolution of a Community

Evolution of a Community

QB3 Innovation Workspace

Industry

Venture

Services

Govt. Agencies

International Partners

QB3 BioInnovation Ecosystem Start-up Companies

Private Sector

Investors

Universities

Governments • improved health • economic growth

• public service mission • equity return

• deal flow • de-risking

• technology • M&A • Services income

• market/regulatory expertise • Co-investment • Affiliation fees

• management • seed funding

• discoveries • biological expertise

• Research support • QB3 support

A University-anchored Bioeconomy Community