Food Matters Live

Understanding the benefits of Matcha Green Tea for ageing and age related disease.

Professor Michael Lisanti

Katherine Swift – Founder of OMGTea

The OMGTea Story

At OMGTea we celebrate the full, chaotic and sometimes challenging lives that people lead.

We believe they’re extraordinary lives.

So our purpose is to bring them extraordinary

products to match.

So what exactly is matcha?

1. Tea Plant

2. Shaded

3. Steamed & Freeze dried

4. Ground

5. History

Problems we could tackle • + 50,000 women diagnosed with breast cancer in UK each year.

• In the UK, 64% of adults are classed as being overweight or obese.

64%

Obese

UK ADULT

POPULATION

The Science

• Professor

• Michael P. Lisanti

• MD-PhD, FRSA

• Chair of Translational Medicine

• University of Salford

• Greater Manchester, UK

• H-index >140

• >540 Publications

• >75,000 citations

The Science

Four Main Ageing Associated Diseases

• Heart Disease

• Diabetes

• Dementia

• Cancer

Overall Goal: Increase Healthspan

by Reducing Ageing Associated Diseases

The Clinical Problem

Tumor Recurrence, Metastasis

and

Drug Resistance

https://en.wikipedia.org/wiki/Cancer_stem_cell

Nature Reviews Clinical Oncology (April 2015)

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Doxycycline

Is there anything available as a

Dietary Supplement

or Nutraceutical,

that can mimic the beneficial effects

of Doxycycline ?

Proteomics Analysis

The Potential

Down-regulation (fold change) Green tea

Down-regulation (fold change) Doxycycline

PRKDC

PRKDC DNA-dependent protein kinase catalytic

subunit

24.43 14.71

GPD2

Glycerol-3-phosphate dehydrogenase, mitochondrial

2.10 5.29

ECI1

Enoyl-CoA delta isomerase 1, mitochondrial

1,698.11 2.95

HSPD1

60 kDa heat shock protein, mitochondrial

7.79 2.24

UQCRC2

Cytochrome b-c1 complex subunit 2, mitochondrial

65.99 1.91

SDHA

Succinate dehydrogenase complex subunit A

14.98 1.88

FASN Fatty acid synthase Infinity 1.83

ATP5F1

ATP synthase, H+ transporting, mitochondrial F0

complex, subunit b

3.52 1.57

Matcha Green Tea Shares

Mitochondrial Targets with Doxycycline

Matcha Green Tea Slows Down Mitochondrial Respiration

Matcha Green Tea Inhibits the Propagation of Cancer Stem Cells (CSCs)

Doxycycline also Increases Life Span

in C. elegans (worms),

a Model Organism for Ageing

The Potential

1. Matcha green tea drinks do not result in adverse physiological responses and could substantially enhance fat oxidation.

• Drinking matcha increases fat burning, which may boost weight loss for those undertaking regular exercise.

• Drinking matcha also had no adverse physiological effects such as raised heart rate or blood pressure.

“To be able to come out with these findings on fat oxidation and performance is just wonderful. I expect an increased interest to discover additional potential of matcha intake in the world of diet and exercise.”

Mark Willems, Professor in Exercise Physiology at the University of Chichester