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E N V I R O N M E N T A L H E A L T H P E R S P E C T I V E S,

december 2014, ročník 122, číslo 12

ONTHECOVER Detroit has a long history of heavy industrialization; without visiting the city, it is easy to imagine a ruined metropolis. But even the most cursory inspection offers evidence of resilience in the face of repeated environmental injuries. In the words of Detroit’s motto, “We hope for better things; it will arise from the ashes.”

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SPHERESONINFLUENCEAdvancedThinking:PotableReuseStrategiesGainTractionRichard Dahl | A332 An estimated 22 trillion of gallons of wastewater are produced annually in North America. The reuse of wastewater for drinking is not a new idea, but it’s getting more attention as the squeeze tightens between drinking-water supply and demand. SCIENCESELECTIONS RitualRisk:IncenseUseandCardiovascularMortalityNancy Averett | A336 Also see Pan et al., p. 1279 Assessing the Impact of Aerial Spraying:Mancozeb Exposures amongPregnantWomenLivingnearBananaPlantationsCarol Potera | A337 Also see van Wendel de Joode et al., p. 1321

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PFOAandHighCholesterol:BasisfortheFindingofaProbableLinkKellyn S. Betts | A338 Also see Winquist and Steenland, p. 1299 EDCs and Estrogen Receptor Activity: A Pathway to Safer ChemicalDesign?Julia R. Barrett | A339 Also see Delfosse et al., p. 1306 REVIEWSMolecular Signaling Network Motifs Provide a Mechanistic Basis forCellularThresholdResponsesQiang Zhang, Sudin Bhattacharya, Rory B. Conolly, Harvey J. Clewell III, Norbert E. Kaminski, and Melvin E. Andersen | 1261 Mitochondria,Energetics,Epigenetics,andCellularResponsestoStressDaniel T. Shaughnessy, Kimberly McAllister, Leroy Worth, Astrid C. Haugen, Joel N. Meyer, Frederick E. Domann, Bennett Van Houten, Raul Mostoslavsky, Scott J. Bultman, Andrea A. Baccarelli, Thomas J. Begley, Robert W. Sobol, Matthew D. Hirschey, Trey Ideker, Janine H. Santos, William C. Copeland, Raymond R. Tice, David M. Balshaw, and Frederick L. Tyson | 1271 RESEARCH IncenseUseandCardiovascularMortalityamongChineseinSingapore:TheSingaporeChineseHealthStudyAn Pan, Maggie L. Clark, Li-Wei Ang, Mimi C. Yu, Jian-Min Yuan, and Woon-Puay Koh | 1279 Also see Science Selections, p. A336 ComparativeAssessmentoftheEffectsofClimateChangeonHeat‐andCold‐RelatedMortalityintheUnitedKingdomandAustraliaSotiris Vardoulakis, Keith Dear, Shakoor Hajat, Clare Heaviside, Bernd Eggen, and Anthony J. McMichael | 1285 VariabilityinTemperature‐RelatedMortalityProjectionsunderClimateChangeTarik Benmarhnia, Marie-France Sottile, Céline Plante, Allan Brand, Barbara Casati, Michel Fournier, and Audrey Smargiassi | 1293 Modeled PFOA Exposure and Coronary Artery Disease, Hypertension,andHighCholesterolinCommunityandWorkerCohortsAndrea Winquist and Kyle Steenland | 1299 Also see Science Selections, p. A338

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Structural and Functional Profiling of Environmental Ligands forEstrogenReceptorsVanessa Delfosse, Marina Grimaldi, Vincent Cavaillès, Patrick Balaguer, and William Bourguet | 1306 Also see Science Selections, p. A339 HouseholdCookingwithSolidFuelsContributes toAmbientPM2.5AirPollutionandtheBurdenofDiseaseZoë A. Chafe, Michael Brauer, Zbigniew Klimont, Rita Van Dingenen, Sumi Mehta, Shilpa Rao, Keywan Riahi, Frank Dentener, and Kirk R. Smith | 1314 Aerial Application ofMancozeb andUrinary Ethylene Thiourea (ETU)Concentrations among Pregnant Women in Costa Rica: The Infants’EnvironmentalHealthStudy(ISA)Berna van Wendel de Joode, Ana María Mora, Leonel Córdoba, Juan Camilo Cano, Rosario Quesada, Moosa Faniband, Catharina Wesseling, Clemens Ruepert, Mattias Öberg, Brenda Eskenazi, Donna Mergler, and Christian H. Lindh | 1321 Also see Science Selections, p. A337 RisksandBenefitsofGreenSpacesforChildren:ACross‐SectionalStudyofAssociationswithSedentaryBehavior,Obesity,Asthma,andAllergyPayam Dadvand, Cristina M. Villanueva, Laia Font-Ribera, David Martinez, Xavier Basagaña, Jordina Belmonte, Martine Vrijheid, Regina Gražulevičienė, Manolis Kogevinas, and Mark J. Nieuwenhuijsen | 1329 Pyrethroid Pesticide Exposure and Parental Report of LearningDisabilityandAttentionDeficit/HyperactivityDisorderinU.S.Children:NHANES1999–2002Lesliam Quirós-Alcalá, Suril Mehta, and Brenda Eskenazi | 1336 Neurobehavioral Function in School‐Age Children Exposed toManganeseinDrinkingWaterYoussef Oulhote, Donna Mergler, Benoit Barbeau, David C. Bellinger, Thérèse Bouffard, Marie-Ève Brodeur, Dave Saint-Amour, Melissa Legrand, Sébastien Sauvé, and Maryse F. Bouchard | 1343 Green and Blue Spaces and Behavioral Development in BarcelonaSchoolchildren:TheBREATHEProjectElmira Amoly, Payam Dadvand, Joan Forns, Mónica López-Vicente, Xavier Basagaña, Jordi Julvez, Mar Alvarez-Pedrerol, Mark J. Nieuwenhuijsen, and Jordi Sunyer | 1351 Characteristics ofWalkable Built Environments and BMI z‐Scores inChildren:EvidencefromaLargeElectronicHealthRecordDatabaseDustin T. Duncan, Mona Sharifi, Steven J. Melly, Richard Marshall, Thomas D. Sequist, Sheryl L. Rifas-Shiman, and Elsie M. Taveras | 1359