流感疫苗暨 肺炎鏈球菌疫苗 - linyuan-hosp.com.t · 肺炎鏈球菌疫苗 護理部 ... 8.老年人及幼兒 . 流感的預防 ... 1.預防流感最有效的方法就是接種流感疫苗
Design of immune system Immune system Self/non-self recognition The state of protection from...
-
Upload
gavin-baker -
Category
Documents
-
view
244 -
download
0
Transcript of Design of immune system Immune system Self/non-self recognition The state of protection from...
- Slide 1
- Slide 2
- Design of immune system
- Slide 3
- Immune system Self/non-self recognition The state of protection from infectious disease Memory Acceptance vs rejection Innate immunityAdaptive immunity
- Slide 4
- Colonize the host Find a nutritionally compatible niche in the hosts body Avoid, subvert, or circumvent the hosts innate and adaptive immune responses Replicate, using host resources Exit and spread to a new host Antigen (Ag) Establishment of infection
- Slide 5
- Innate immunity Physical barrier Biochemical barrier Phagocytes Inflammation
- Slide 6
- Inflammation (cells, soluble mediators) Innate immunity
- Slide 7
- Complement Inflammation Phagocytes Induction of adaptive immunity
- Slide 8
- Phagocytes Innate immunity Recognition of PAMPs by pattern recognition receptors
- Slide 9
- Adaptive immunity Humoral immunity Cell-mediated immunity (CMI) B cells: Antibody T cells
- Slide 10
- Immune recognition Innate (non-specific) immunity Adaptive (specific) immunity Pattern recognition receptors Epitope recognition receptors
- Slide 11
- Innate immunity Adaptive immunity
- Slide 12
- Part I Part III Part II Cells Organs & tissues Functions Antibody response T cell response
- Slide 13
- Cells Organs & tissues Functions Part I
- Slide 14
- WBC Myeloid cells Lymphoid cells Granulocytes Macrophages/ Dendritic cells TB CD4 CD8 NK Immune cells (Natural killer cells) (Tc)(Th) (DC) Adaptive immunity Innate immunity
- Slide 15
- Granulocytes Neutrophils Eosinophils Basophils Mast cells (Degranulation)
- Slide 16
- Ag Innate Adaptive ExtracellularPhagocytes B cells Intracellular NK CD8 Tc cells (Altered self) Cytotoxicity CD4 Th Humoral response Cell-mediated immunity (CMI) 1 2 Function of immune cells Ag elimination is based on Ag location DC
- Slide 17
- Adaptive immunity NKPhagocytes Intracellular Extracellular Humoral immunity CMI Th1Th2
- Slide 18
- Infected cells Intracellular Ag Innate immunity Altered self
- Slide 19
- Lymphocytes Ag-specific receptor Adaptive immunity Epitope recognition receptors
- Slide 20
- Lymphoid organs and tissues Primary (Central) Bone marrow Thymus Secondary (Peripheral) Lymph nodes Spleen Peyers patches
- Slide 21
- Immune design Adaptive immunity Lymph nodes
- Slide 22
- Lymph node distribution in the body
- Slide 23
- Slide 24
- Slide 25
- Route Antigen-presenting cells (APC) Inflammation
- Slide 26
- DC T
- Slide 27
- 1. Antigen specificity 2. Diversity 3. Immunological memory 4. Self tolerance Adaptive immunity
- Slide 28
- Design of immune system Ag-specific recognition Pattern recognition
- Slide 29
- Clonal selection Low frequency Immune diversity Adaptive immunity Primary (Central) Secondary (Peripheral) B cell development and humoral immunity Specificity
- Slide 30
- Adaptive immunity Clonal expansion & differentiation
- Slide 31
- Memory response Adaptive immunity
- Slide 32
- Antibody response Part II
- Slide 33
- Antibody structure
- Slide 34
- Antibody structure Effector function Fab Fc Fab: Ag-binding fragment Fc: constant Effector function: complement, FcR
- Slide 35
- Antibody structure Epitope
- Slide 36
- Antibody isotype IgM IgG IgA Fc
- Slide 37
- Five classes of antibody Effector function
- Slide 38
- IgM Natural antibody
- Slide 39
- C4b C1s
- Slide 40
- Five classes of antibody Effector function
- Slide 41
- Opsonization: Enhanced phagocytosis by mediators (opsonin) FcR
- Slide 42
- Antigen-antibody interaction Immune complex
- Slide 43
- IgA transport
- Slide 44
- IgE
- Slide 45
- Ab is a mediator to activate downstream immune pathways
- Slide 46
- Memory response IgM IgG C
- Slide 47
- Class switching
- Slide 48
- Neutralizing (Blocking) Binding FcR Complement activation Function of antibody
- Slide 49
- T cell responsePart III CD4 Th B cells CD8 Tc Costimulation (Signal 2) Ag specific recognition (Signal 1) Cytokine (Signal 3) Humoral immunity CMI
- Slide 50
- T cell Receptor (TCR) Ag specific recognition (Signal 1)
- Slide 51
- Antigen-presenting cells (APC) T cell recognition & activation
- Slide 52
- APC T-DC interaction MHC: antigen presentation Ag specific recognition (Signal 1)
- Slide 53
- T cell recognition: MHC restriction CD8CD4
- Slide 54
- Co-receptor: CD4 & CD8
- Slide 55
- MHC HLA: Human leukocyte antigen Epitope
- Slide 56
- MHC APC
- Slide 57
- Ag processing & presentation to CD4 T
- Slide 58
- Ag processing & presentation to CD8 T
- Slide 59
- Slide 60
- T cell activation & expansion Costimulation (Signal 2) Clonal expansion
- Slide 61
- Th cell differentiation IL12 IL4
- Slide 62
- Cytokine (Signal 3) in T cell differentiation 1 Cytokine: Effector function Interferon
- Slide 63
- Slide 64
- Slide 65
- CD4 Th B cells CD8 Tc Costimulation (Signal 2) Ag specific recognition (Signal 1) Cytokine (Signal 3) Humoral immunity CMI 1 2
- Slide 66
- Slide 67
- APC 2 Costimulation
- Slide 68
- Innate immunity Adaptive Immunity (Humoral, CMI)
- Slide 69
- Adaptive immunity Clonal expansion & differentiation
- Slide 70
- 1. Antigen specificity 2. Diversity 3. Immunological memory 4. Self tolerance Adaptive immunity
- Slide 71
- Tolerance
- Slide 72
- Host-pathogen relationship Persistent infection Immune evasion Persistence