Data File #F802-DST-001-Rev2 G3 Bioreactor Control...

G3 Bioreactor Control Platform

Flexible and reliable bioreactor control enabled by SmartPart intelligence

Data File #F802-DST-001-Rev2

Scalablity Transfer any process from 0.5 L to 2000 L

Modularity Configure to control most any bioreactor size or brand

Adaptability Plug-and-play SmartParts and 3rd party peripherals

ROI Increase productivity and minimize down-time

Totality Optimize globally through vessel harmonization

SmartControllers | Bioreactor Controllers

Finesse Smart Controllers

Universal ControlFinesse has designed its third-generation

SmartController bioreactor hardware to

be highly configurable and easily adapted

to both cell culture and fermentation

applications. By leveraging SmartParts

components, all G3 controllers have the

capability and flexibility required to optimize

any process, whether in the laboratory

or in a cGMP-compliant manufacturing

plant. The G3 control platform incorporates

innovative features that enhance the

productivity, quality, and reproducibility of

batch, fed batch, or perfusion processes.

Upstream process scale-up strategies need

not be limited to one bioreactor vendor.

G3 SmartControllers have been designed

to easily connect to most brands of glass,

single-use, or rocker bioreactors without

sacrificing the quality of control. G3 systems

are modular in design, so the hardware

configuration can easily evolve with any

process, and integrate additional functionality

and third-party peripherals as needed.

Compatible Bioreactor Vessels

Controller Bioreactor Type Manufacturer Working Volume (L)

G3Lab™ Universal

Glass Finesse 1, 2, 5, 10

Applikon 0.9, 1.7, 2.7, 3.4, 5.4, 12, 16

Sartorius STR® 1, 2, 5, 10

New Brunswick Scientific

1, 2.2, 5.6, 10.5

Single-Use Millipore Mobius CellReady™

2.4

New Brunswick Scientific

3.4, 10.5, 45

Xcellerex XDR™ 10

Rocker Finesse 10, 20, 50

GE Wave™ 10, 20, 50

G3Lite™ Single-Use Thermo Scientific HyPerforma™ SUB

50, 100, 250, 500, 1000, 2000

Millipore Mobius CellReady™

50, 200

G3Pro™ G3Flex™

Single-Use Thermo Scientific HyPerforma™ SUB

50, 100, 250, 500, 1000, 2000

Xcellerex XDR™ 50, 200, 500, 1000, 2000

ATMI PadReactor™ 25, 50, 300, 600, 1350

Millipore Mobius CellReady™

50, 200

Sartorius STR® 50, 200, 500, 1000

ASI™ 50, 300


G3Lab Universal The G3Lab Universal controls bench-top bioreactors (single-use

or reusable up to 20 L) and rockers (up to 50 L). The system consists of a

utility tower and a TruFlow gas manifold. G3Lab Universal controllers minimize

footprint while maximizing process flexibility. By leveraging SmartParts across

the range of configurations, G3Lab Universal systems enable fully traceable

cGMP process scale-up or scale-down in the laboratory environment.

G3Lite G3Lite systems control single-use Thermo Scientific HyPerforma™ SUB

(50 L to 2000 L) and Millipore Mobius CellReady™ (50 L to 200 L) bioreactors.

The system consists of a control tower that leverages SmartPart

transmitters, MFC’s, and pumps for superior performance. G3Lite

controllers are fully self-contained, movable units that can be operated

singly or networked. They are engineered to optimize capital cost without

sacrificing the option of use in cGMP-certified production facilities.

G3Pro Universal The G3Pro Universal controls single-use bioreactors (25 L to 2000 L)

and mixers (50 L to 2000 L). The system consists of a utility tower, a

TruFlow gas manifold, and a Vessel Adaptor Box specific to the vessel

being controlled. SmartPart transmitters and pumps are used for

maximum flexibility. G3Pro controllers can be mounted on fixed skids

or movable carts, can be quickly reconfigured or expanded for multi-

product applications, and have complete cGMP documentation.

G3Flex G3Flex systems are custom designed to run unique or highly complex

processes in challenging environments (e.g., BSL-3).G3Flex systems can

be fully integrated or modular. A typical system will include a utility tower,

pump tower, and gas manifold, with optional accessories for perfusion,

harvest, or gravimetric feeding. G3Flex systems can be used with bioreactors

of any type or size in R&D, PD, pilot, and production applications.

4 Modular Configurations

R&D // PD Production


Bespoke control for any process



SmartParts make your process excellent.

SmartParts are intelligent, plug-and-play

hardware building blocks for measurement

and control of bioprocesses. Designed for

applications ranging from R&D to cGMP-

compliant manufacturing processes, SmartParts

are hot-pluggable, have built-in diagnostics

and factory calibrations, can be auto-detected

by the network, and provide optimized local

control of the given bioprocess function.

Supercharge your controller. Be SMART.Finesse’s third-generation SmartControllers are

driven by SmartParts. These G3 systems are

easily configured to control any size or brand

of upstream vessel. They enhance bioprocess

reproducibility by exploiting the local control

capability of each SmartPart, and increase

productivity by decreasing the loading on

the primary control and data networks.

TruSens Blade Transmitter Digital signal transmission for sterilizable

pH / DO and temperature sensors

TruFluor pH or DO Blade Transmitter Digital signal transmission for

single-use pH or DO optical sensors

TruTorr Blade Transmitter Digital signal transmission for

single-use pressure sensors

SmartScale Blade Transmitter Digital signal transmission

for load cells and scales

SmartPumps Digital control of Watson Marlow®

Series 114 / 313 / 520 / 620 pump heads

TruFlow Gas Manifold Digital control of mass flow controllers

and associated solenoids

SmartMotors Digital control of motors for bioreactor

agitators and rockers

SmartParts = Transmitters + Actuators


G3Lab UniversalSPECIFICATIONS

Utility Tower Dimensions (H × W × D) 438.4 x 240 x 482.6 mm (17.3 x 9.5 x 19 in)

Enclosure Rating NEMA2

Operating Temperature 5°C to 40°C (41°F to 104°F)

Storage Temperature -40°C to 70°C (-40°F to 158°F)

Relative Humidity 5% to 95% Non-Condensing

Certifications Tested and verified as meeting CE standards EN-60101 and EN 61325

Weight / Shipping Weight 14 kg / 21.4 kg (31 lbs / 47 lbs)

Agitation

Finesse SmartMotor Controller – Glass Vessel Agitator or Rocker

Connection to Vessel Adapter Box – Thermo Scientific HyPerforma™ SUB Only

Serial Port Connection to GE Wave™ Rocker – EHT Model Only

pH (Up to 2 Inputs)TruSens Transmitter (Electrochemical Sensors) or TruFluor pH Transmitter (Rocker, Single-Use Vessel)

DO (Up to 2 Inputs)TruSens Transmitter (Electrochemical Sensors) or TruFluor DO Transmitter (Rocker, Single-Use Vessel)

Temperature TruSens Transmitter (RTD) or TruFluor (Rocker)

Foam Level Conductivity Input

Liquid Control Four (4) Variable-Speed Peristaltic SmartPumps, Watson-Marlow® Series 114

Cold Finger Solenoid Digital Solenoid Valve

Gas Control (TruFlow)Standard: Four (4) MFCs with Two (2) Output ConnectorsOptional: Six (6) MFCs with Three (3) Output Connectors

Scales / Load Cells Analog Input via Scale Port

Auxiliary Connectors Seven (7) Analog Inputs and Four (4) Analog Control Loops

Digital Input Two (2) 24V DC

Digital Output Two (2) Dry-Relay Contacts

Thermal Control Heater Blanket, Chilled Water Source

External Pumps Two (2) Watson-Marlow® Pumps on a Finesse Pump Tower

pH Cables K8, VP, TruFluor

DO Cables D4, VP6, VP8, TruFluor

Heater IEC5-15 Receptacle

VesselsGlass, 1 L to 20 LSingle-Use (SUB), 2.4 L to 45 LRocker, 10 L to 50 L

Standard Colors* (pictured below)*Also available in clearcoated stainless as standard. Additional and custom colors are available at extra charge and longer lead times. The color examples shown are for reference only. Printed and on-screen colors may vary from actual product color.

Lime Blueberry Raspberry Tangerine Sterling Silver


G3LiteSPECIFICATIONS

Utility Tower Dimensions (H x W x D) 1600 x 680 x 540 mm (63 x 27 x 21 in)

Enclosure Rating NEMA12 / IP52

Operating Temperature 5ºC to 40°C (41ºF to 104°F)

Storage Temperature -25ºC to 70°C (-15ºF to 158°F)


Certifications Manufactured to conform to CE specifications EN-60101 and EN-61325

Weight / Shipping Weight 68 kg / 136.1 kg (150 lbs / 300 lbs)

Agitation Thermo Scientific HyPerforma™ SUBs: 1/4HP or 1/2HP AC 3-Phase Induction Motor

pH (Up to 2 Inputs) TruSens Transmitter (Electrochemical), TruFluor pH Transmitter (Single-Use)

DO (Up to 2 Inputs) TruSens Transmitter (Electrochemical), TruFluor DO Transmitter (Single-Use)

Temperature TruSens Transmitter (RTD) and/or TruFluor pH/DO Transmitters (Single-Use)

Pressure TruTorr Transmitter (Single-Use)

Liquid control Four (4) variable-speed peristaltic SmartPumps, Watson Marlow® Series 114, 313, or 520

Gas Control (TruFlow)Basic: Four (4) MFCs with Two (2) Output Connectors Recommended: Six (6) MFCs with Three (3) Output Connectors

Scales / Load Cells SmartScale Transmitter

Auxiliary Two (2) Analog Inputs (12-bit, 4 to 20 mA); Two (2) Auxiliary Control Loops (4 to 20 mA)

Digital Output Two (2) 24V Outputs; One (1) Dry Relay Alarm Contact

Thermal Control Heater Blanket or Analog Temperature Control Unit (TCU)

Vent Filter Heaters Two (2) Heaters for Pall KA3™ or Meissner UltraCap® 10-inch Filters

External PumpsUp to two (2) Additional External SmartPumps, Watson Marlow® Series 114, 313, 520, 620 Freestanding or on a Finesse SmartPump Tower



Vent Filter Heater Connection IEC 60309 6H Receptacle 2P+E or External Heater Power Box for Larger Jacketed SUBs

SUBs (Single-Use Vessels) 50 L to 2000 L

HMI Standard Flatscreen Color Monitor, Washable Keyboard and Mouse


*Note that the controller is not designed to be free-standing. For this reason the controller is only shipped with the cart, for a combined weight of 116 kg (256 lbs)

SPECIFICATIONS

Utility Tower Dimensions (H x W x D) 914.4 x 609.6 x 228.6 mm (36 x 24 x 9 in)

Cart Dimensions (H x W x D) Stand Alone Mounting Cart with Wheels

178 x 71 x 81 cm (70 x 28 x 32 in)

Enclosure Rating NEMA 12/IP54 or optionally NEMA 4X/IP65

Operating Temperature 5°C to 40°C (41ºF to 104°F)

Storage Temperature -25°C to 85ºC (-13ºF to 185ºF)


Certifications Tested and Verified as Meeting CE Standards EN-60101 and EN 61325

Weight / Shipping weight 18.1 kg / 41 kg (40 lbs / 90 lbs)

Cart Weight* 75 kg (165 lbs)

Agitation Depends on Vessel Manufacturer, Control Through VAB (Vessel Adaptor Box)

pH (Up to 3 Inputs) TruSens Transmitter (Electrochemical), TruFluor pH Transmitter (Single-Use)

DO (Up to 3 Inputs) TruSens Transmitter (Electrochemical), TruFluor DO Transmitter (Single-Use)

Temperature TruSens Transmitter (RTD) and/or TruFluor pH/DO Transmitters (Single-Use)

Pressure TruTorr Transmitter (Single-Use)

Liquid control Four (4) variable-speed peristaltic SmartPumps, Watson Marlow® Series 114, 313, or 520

Gas Control (TruFlow)Standard: Six (6) MFCs with Three (3) Output ConnectorsOptional: Four (4) MFCs with Two (2) Output Conntectors

Scales / Load Cells Analog Input on Vessel Adapter Box

Auxiliary Eight (8) Analog Inputs and Four (4) Analog Control Loops

Digital Output Two (2) 24V Outputs; One (1) Dry Relay Alarm Contact

Thermal ControlHeater Blanket or Chilled Water Source (up to 250 L Vessel)Thermal Control Unit (TCU) for Jacketed Vessels

Vent Filter Heaters MKS Cable Compatible with Pall or Meissner Vent Filter Heaters

External Pumps Watson Marlow (Series 100, 300, 500 or 600) in Standalone SmartPump or SmartPump Tower



Heater Connection Cable Specific to Heater Connected at VAB (Vessel Adapter Box)

SUBs (Single-Use Vessels) 50 L to 2000 L

Vessel Adapter Box (VAB)

Thermo Scientific HyPerforma™ SUB: 50, 100, 250, 500, 1000, 2000 LGE / Xcellerex XDR: 50, 200, 500, 1000, 2000 LATMI PadReactor: 25, 50, 600, 1350 LMillipore Mobius CellReady: 50, 200 LSartorius STR: 50, 200, 500, 1000 L ASI™ 50, 300 L

Third Party Sensors (Analog Output) CO2 – Mettler Toledo®; Cell Density – Endress+Hauser; Cell Viability – Aber™ / Fogale; Pressure / Flow

HMI 19 in Color Touch Screen Industrial LCD, NEMA 4X, 1280 x 1024, 24-Bit Color, Keyboard and Mouse

G3Pro Universal


G3FlexThe Finesse G3Flex is a custom bioprocess controller based on

SmartParts and designed to fill a specific application requirement.

For more information about the Finesse G3Flex, please

contact your local Finesse representative.

* Subject to change without notice. **Minimum pressure differential depends on flow rate 30 slpm requires 20 psi differential, 1 slpm or less requires 10 psi.

TruFlow Gas ManifoldGENERAL SPECIFICATIONS*

Operating Temp 5ºC to 40ºC (41ºF to 104ºF)

Storage Temp -25ºC to 70ºC (-15ºF to 158ºF)

Relative Humidity 5% to 95% (Non-Condensing)

Certification CE (EN-61326 and EN-61010)

Inlet Pressure 0.7 to 3.45 bar / 10 to 50 psig

Outlet Pressure 0 to 1.38 bar / 0 to 20** psig

Accuracy ±0.8% of Rate ±0.3% Full Scale (Burkert)

Repeatability ±0.1% Full Scale (Burkert)

PHYSICAL DESCRIPTION 4x2 GAS MANIFOLD 6x3 GAS MANIFOLD

Dimensions (H x W x D) 190.5 x 177 x 184.2 mm (7.5 x 7.0 x 7.25 in) 190.5 x 267 x 184.2 mm (7.5 x 10.5 x 7.25 in)

Rating NEMA 2 / IP11 NEMA 2 or NEMA 4X (Optional)

Weight / Shipping Weight 4.5 kg / 6.8 kg (10 lbs / 15 lbs) 7.3 kg / 9.1 kg (16.2 lbs / 20 lbs)

COMPONENTS

Mass Flow Controllers Up to Four (4) Per Vessel for G3Lab Up To Six (6) Per Vessel (Standard)

Solenoid Valves Two (2) Per Gas Three (3) Per Gas

Headers / Spargers Two (2) Total Per Manifold Three (3) Total Per Manifold

Every effort has been made to ensure the accuracy of the information in this document. However, Finesse

reserves the right to change its products without notice. The following are Finesse Solutions, Inc. registered

trademarks: TruView, TruBio, TruBio DV, TruBio µC, SmartOPC, TruService, TruTorr, TruFluor, TruLogic, TruConnect,

TruMigrations, TruCables, TruHousings, SmartGlass, SmartRocker, TruDO, TrupH, SmartFactory, SmartChip,

SmartSystems, SmartBag, SmartPuck, SmartReader, SmartBag Reader, SmartTray, SmartController, SmartSensor.

© 2013-2014, Finesse Solutions, Inc. All other trademarks are the property of their respective owners.

Finesse Solutions, Inc.

Global Headquarters

3501 Leonard Court

Santa Clara, CA 95054

USA

Toll free +1 800 598 9515

Tel +1 408 570 9000

Fax +1 888 235 6086

www.finesse.com

[email protected]

Europe

Via Sogn Gieri 27a

CH-7402 Bonaduz,

Switzerland

+41 81 641 2000

Benelux, Ireland

& Scandinavia

Van Slingelandtlaan 13

3332 JJ Zwijndrecht

The Netherlands

+31 6 836 00 180

Asia-Pacific

3A Intl Business Park,

#07-08

ICON@IBP Tower A

Singapore 609935

+65 8322 8128

Shanghai

+86 138 16082457

Data File #F802-DST-001-Rev2 G3 Bioreactor Control...

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