CVM faculty on Bacterial Infectious Diseases
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CVM faculty on Bacterial Infectious Diseases
Yinduo JiDepartment of Veterinary Biomedical
Sciences
Faculty Expertise• Epidemiology• Bacterial pathogenesis• Mechanism of antibiotic resistance• Microbiome/metagenomics • Vaccine development• Novel antibacterial discovery• Diagnosis
Bacterial pathogenesis• Gram-negative pathogens:– Escherichia coli, Salmonella enterica, Lawsonia
intracellularis, Haemophilus parasuis
• Gram-positive pathogens:– Staphylococcus aureus, including MRSA,
Streptococcus suits, Mycobacterium avium subsp. paratuberculosis (MAP) and M. bovis
• Microbe-host interaction• Microbe-microbe interactions
Approaches
• Genetics• Genomics• Metagenomics• Proteomics• System biology• Cell culture• Animal Models
Current projects• Identification and validation of novel targets in vitro
and in vivo• Development of high throughput screening of
antibacterial inhibitor• Whole-cell screening of novel antibacterial small
molecules• Identification of mode of action for novel antibacterial
agents• Investigation of molecular mechanisms of antibiotic
resistance• Microbial population shifts in response to antibacterials