CURRICULUM VITAE - Ohio State University · Web view1)International Web Course on Necrotizing...

CURRICULUM VITAE

_______________________________________________

Gail E. Besner, M.D., F.A.C.S., F.A.A.P.

September, 2016

Table of Contents______________________________________________________________________________

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1. Personal Details…………………………………………………………………………...….3

2. Career Goals / Major Accomplishments............................................................................4-5

3. Medical Leadership / Advocacy / QI Development / Board Membership..........................6

4. Education...............................................................................................................................7-8

4. Appointments........................................................................................................................8-9

5. Certifications......................................................................................................................10-11

6. Awards and Honors..........................................................................................................12-19

7. NIH Assignments...................................................................................................................19

8. Patents....................................................................................................................................20

9. Professional Organizations..............................................................................................21-24

10. Administrative Activities.................................................................................................24-29

11. Editorship of Journals..........................................................................................................30

11. Grant Support.................................................................................................................31-38

12. Trainees............................................................................................................................38-52

13. Publications.......................................................................................................................52-72

14. Presentations...................................................................................................................73-123

15. Visiting Professorships.................................................................................................124-125

16. Invited Lectureships.....................................................................................................127-132

17. Additional Activities.....................................................................................................132-134

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Gail Ellen BESNER, M.D.F.A.C.S., F.A.A.P.

CURRICULUM VITAE

TITLE: H. William Clatworthy, Jr. Professor of Surgery Nationwide Children’s Hospital

Chief of the Department of Pediatric SurgeryProfessor of Pediatric Surgery and PediatricsAssociate Director, Pediatric Surgery Training ProgramNationwide Children’s Hospital

Chief of the Division of Pediatric SurgeryDepartment of SurgeryThe Ohio State University College of Medicine

OFFICE ADDRESS: Department of Surgery

Nationwide Children's Hospital700 Children's DriveColumbus, Ohio 43205Phone: (614) 722-3900FAX: (614) 722-3903

HOME ADDRESS: 4542 Sixpenny Circle, Dublin, Ohio 43016(614) 792-5454

PLACE OF BIRTH: New York, New York

CITIZENSHIP: U.S.A.

MARITAL STATUS: Married to:David Brigstock, Ph.D., Professor of SurgeryThe Ohio State University College of Medicine Nationwide Children's Hospital, Columbus, OH Specialty: The role of Connective Tissue Growth Factor (CTGF) in liver and pancreatic fibrosis

CHILDREN: Matthew Aaron Date of Birth - June 22, 1994Nicole Michelle Date of Birth - April 25, 1997

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Curriculum VitaeGAIL ELLEN BESNER, M.D.

CAREER GOALS

To utilize a top leadership position to bring a Children’s Hospital to the forefront of academic patient care, pediatric surgical research and education;

To mentor the next generation of academic pediatric surgeons;

To maintain local, national and international recognition as a leader in pediatric surgery;

To maintain a busy clinical practice of pediatric surgery;

To optimize the career development of students, residents, and junior faculty;

To teach at various levels;

To continue basic science research in the cellular biology, protein biochemistry and molecular biology of growth factors, and the role(s) of growth factors in neonatal necrotizing enterocolitis, intestinal ischemia-reperfusion injury and wound healing;

To continue translational research of the use of heparin-binding EGF-like growth factor (HB-EGF) in the prevention of intestinal injury including neonatal necrotizing enterocolitis

To remain an advocate for children and children’s health care.

MAJOR ACCOMPLISHMENTS AT NATIONWIDE CHILDREN’S HOSPITAL

Establishment and direction of a Basic Science Research Laboratory in Pediatric Surgery, which did not previously exist. The Besner Laboratory has secured continuous funding from the National Institutes of Health since 1995.

Establishment of the Pediatric Surgery Research Laboratory as one of the premiere laboratories in Pediatric Surgical Research in the United States.

Increased NCH Department of Pediatric Surgery National Institutes of Health Funding from 0 to over $10 million dollars.

Increased the publication and presentation record of the NCH Department of Pediatric Surgery by 10-fold.

One of extremely few pediatric surgeons to make a discovery in the research laboratory and to carry the research through to FDA approval for human clinical trials.

Mentored research careers of numerous trainees who have won a multitude of research awards.

Mentored research careers of junior faculty who received NIH Training Awards (K Awards).

As Burn Director at Nationwide Children’s Hospital, directed and coordinated an American College of Surgeons (ACS) and American Burn Association (ABA) Verification of the Nationwide Children’s Hospital Burn Unit. This successful burn unit verification was the first of its kind to ever be successfully obtained by a free-standing Children’s Hospital in the United States. The NCH Burn Unit has been an ACS/ABA verified burn unit since 2003.

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Lead surgeon in the successful separation of three sets of conjoined twins at Nationwide Children’s Hospital (refer to final page for further details).

Chosen by the Children’s Circle of Care (CCC) to represent Nationwide Children’s Hospital at the 2010 Children’s Circle of Care North American Leadership Conference. Only one other pediatric surgeon in the United States has ever received this distinction.

Chaired the Search Committee that successfully recruited Dr. Richard Kirschner, a nationally recognized leader in pediatric plastic surgery, to Nationwide Children’s Hospital as the Chief of Pediatric Plastic Surgery in 2010.

Chaired the Search Committee that successfully recruited Dr. Irina Buhimschi, a nationally recognized leader in neonatal research, to Nationwide Children’s Hospital as Director of the Center for Perinatal Research in 2012.

Chaired the Search Committee that successfully recruited Dr. Kevin Klingele, a nationally recognized leader in pediatric orthopedic surgery, to Nationwide Children’s Hospital as the Chief of Pediatric Orthopedic Surgery in 2013.

Successfully mentored and supported the transition of Dr. Renata Fabia as Burn Director at Nationwide Children’s Hospital in 2009.

Supported the career trajectory of Dr. Ben Nwomeh by appointing him as Associate Director of the Pediatric Surgery Training Program at Nationwide Children’s Hospital in 2010 and Director of Pediatric Surgery Training Program in 2014.

Led the recruitment of multiple pediatric surgery faculty members to NCH including Dr. Marc Levitt as Director of the Center for Colorectal and Pelvic Reconstriction, Dr. Rajan Thakkar as Associate Trauma Director and Associate Burn Director, and Dr. Richard Wood as Associate Director of CCPR.

Review and counseling for NIH grant submissions of junior faculty

Continuous NIH funding for over two decades, with two to three R01 grants held at all times

ENDOWED CHAIRS HELD

2008-2012 John E. Fisher Endowed Professor of Neonatal Research Nationwide Children’s Hospital, Columbus, Ohio

2012-present H. William Clatworthy, Jr. Professor of SurgeryThe Ohio State University College of MedicineNationwide Children’s Hospital, Columbus, Ohio

MEDICAL LEADERSHIP DEVELOPMENT

2005-2006 Medical Leadership Program (2-year Program)Nationwide Children’s Hospital, Columbus, Ohio

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Curriculum VitaeGAIL ELLEN BESNER, M.D.3/31/07 Preparing People in Academic Medicine for the Practice of Leadership Course

The Ohio State University College of Medicine Department of Pediatrics, Columbus, Ohio

11/8-20/09 Leadership Development for Physicians in Academic Health CentersHarvard School of Public Health, Boston, Massachusetts

2/21/14 American College of Surgeons Leadership Summit in DC

5/18-21/14 American College of Surgeons Surgeons as Leaders CourseChicago, IL

ADVOCACY EFFORTS

2/21/14 American Academy of Pediatrics Advocacy Day in DCIssues advocated for: Extending the Medicaid payment increase beyond 2014

3/31/14-4/1/14 American College of Surgeons Advocacy Summit in DCIssues advocated for: Increased NIH funding, permanent repeal of the Sustainable Growth Rate (SGR), medical liability reform, trauma and emergency care

4/18-21/15 American College of Surgeons Advocacy Summit in DCIssues advocated for: Increased NIH funding, increased support of cancer clinical trials, trauma, 72 hour rule for Critical Access Hospitals

QUALITY IMPROVEMENT DEVELOPMENT

3/15/13 – 6/15/13 Quality Improvement Essentials CourseNationwide Children’s Hospital, Columbus, Ohio

BOARD MEMBERSHIP

8/1/14- pres Scientific Advisory Board MemberThe Morgan Leary Vaughan FundAn all-volunteer, public charity dedicated to promote public awareness aboutNEC and to advance research to prevent, diagnose, treat, and ultimately, cure NEC.

7/20/16 - pres Scientific Advisory Board MemberNEC SocietyAn all-volunteer, public charity dedicated to promote public awareness aboutNEC and to advance research to prevent, diagnose, treat, and ultimately, cure NEC.

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EDUCATION

HIGH SCHOOL: 1974 Bronx High School of ScienceBronx, New York

PREMEDICAL: 1978 Bachelor of ArtsEDUCATION Cornell University

Ithaca, New YorkMajor: Biochemistry

MEDICAL EDUCATION: 1982 M.D.University of CincinnatiCollege of MedicineCincinnati, Ohio

POST DOCTORAL TRAINING

INTERNSHIP: 1982-1983 Intern in General SurgeryBrigham & Women's HospitalBoston, MassachusettsChief: John A. Mannick, M.D.

RESIDENCIES: 1983-1987 Resident in General SurgeryBrigham & Women's HospitalBoston, MassachusettsChief: John A. Mannick, M.D.

1989-1990 Senior Resident in Pediatric SurgeryThe Children's Hospital of BuffaloBuffalo, New YorkChief: Donald R. Cooney, M.D.

1990-1991 Chief Resident in Pediatric SurgeryThe Children's Hospital of BuffaloBuffalo, New YorkChief: Donald R. Cooney, M.D.

FELLOWSHIPS: 1977-1978 Undergraduate Research Fellowship, Cornell University, Division of Nutritional Sciences, Ithaca, New YorkSupervisor: Virginia Utermohlen, M.D.

1987-1989 Research Fellow in Pediatric SurgeryChildren's Hospital, Boston, MassachusettsSupervisor: M. Judah Folkman, M.D.

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SURGICAL CHAIRS

1982-1987 John A. Mannick, M.D.Brigham & Women's Hospital

1989-1990 Lewis M. Flint, M.D.SUNY at Buffalo

1990-1991 Eddie L. Hoover, M.D.SUNY at Buffalo

1991-1993 Olga Jonasson, M.D.Ohio State University

1993-2000 Ronald M. Ferguson, M.D., Ph.D.Ohio Sate University

2000-2013 E. Christopher Ellison, M.D.Ohio State University

2013-present Robert Higgns, M.D.Ohio State University

HOSPITAL APPOINTMENTS

1991-present Clinical Attending Staff:Nationwide Children's Hospital, Columbus, Ohio Ohio State University Hospital, Columbus, OhioThe Arthur James Cancer Institute, Columbus, Ohio

1991-present Consultant in Pediatric Surgery:Mount Carmel Medical Center, Columbus, OhioRiverside Hospital, Columbus, OhioGrant Hospital, Columbus, OhioDoctor's Hospital, Columbus, OhioSt. Ann's Hospital, Columbus, Ohio

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ACADEMIC APPOINTMENTS

1989-1991 Instructor in SurgeryState University of New York at Buffalo, Buffalo, New York

1991-1997 Assistant Professor of Surgery (Tenure Track)The Ohio State University College of MedicineDepartment of Surgery, Division of Pediatric Surgery Columbus, Ohio

1991-present Director, Pediatric Surgical ResearchThe Ohio State University and Children’s Hospital, Columbus, Ohio

1992-1997 Assistant Professor of PediatricsThe Ohio State University College of Medicine Columbus, Ohio

1992-present Member, The Ohio State UniversityProgram of Molecular, Cellular and Developmental Biology Columbus, Ohio

1994-present Faculty MemberThe Ohio State University Pediatric Oncology ProgramArthur James Cancer Center, Columbus, Ohio

1997-2003 Associate Professor of Surgery with TenureThe Ohio State University College of MedicineDepartment of Surgery, Division of Pediatric SurgeryColumbus, Ohio

1997-2003 Associate Professor of PediatricsThe Ohio State University College of Medicine, Columbus, Ohio

1999-2001 Co-Director, Medical Scientist ProgramThe Ohio State University College of Medicine, Columbus, Ohio

2001-present Member, Integrated Biomedical Sciences Graduate Program,The Ohio State University, Columbus, Ohio

1993-2009 Burn DirectorNationwide Children's Hospital, Columbus, Ohio

2003-present Professor of SurgeryThe Ohio State University College of Medicine, Columbus, Ohio

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2003-present Professor of PediatricsThe Ohio State University College of Medicine, Columbus, Ohio

2005-2009 Associate Program DirectorResidency in Pediatric SurgeryChildren’s Hospital and The Ohio State University College of Medicine, Columbus, Ohio

2009-present Program Director, Residency in Pediatric SurgeryChildren’s Hospital and The Ohio State University College of Medicine, Columbus, Ohio

2009-present Associate Burn DirectorNationwide Children's Hospital, Columbus, Ohio

2010-present Member, Center for Regenerative Medicine and Cell Based TherapiesThe Ohio State University

2012-present Chief of the Department of Pediatric SurgeryNationwide Children’s Hospital, Columbus, Ohio

2012-present Chief of the Division of Pediatric SurgeryThe Ohio State University College of Medicine

BOARD CERTIFICATION

7/1/83 Diplomat of the National Board of Medical Examiners (Certificate #269853)

11/1/88 – 7/1/99 Diplomat of the American Board of SurgeryGeneral Surgery(Certificate #033710)

4/27/92 – 7/1/02 Diplomat of the American Board of SurgeryPediatric Surgery(Certificate # 000561)

10/23/92 – 7/1/03 Diplomat of the American Board of SurgerySurgical Critical Care(Certificate # 000892)

10/16/98 – 7/1/09 Recertification Diplomat of the American Board of SurgeryGeneral Surgery(Certificate # 033710)

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10/19/01 – 7/1/12 RecertificationDiplomat of the American Board of SurgeryPediatric Surgery(Certificate # 000561)

10/18/02 – 7/1/13 RecertificationDiplomat of the American Board of SurgerySurgical Critical Care(Certificate # 000892)

12/10/08 – 7/1/19 Recertification Diplomat of the American Board of SurgeryGeneral Surgery(Certificate # 033710)

9/16/11 – 7/1/22 Recertification Diplomat of the American Board of SurgeryPediatric Surgery(Certificate #000561)

9/13/12 – 7/1/23 RecertificationDiplomat of the American Board of SurgerySurgical Critical Care(Certificate # 000892)

SPECIAL CERTIFICATION

1993 Advanced Burn Life SupportAmerican Burn Association

1993 Advanced Burn Life Support, InstructorAmerican Burn Association

1995 Advanced Trauma Life SupportAmerican College of SurgeonsCommittee on Trauma



2001 Advanced Trauma Life SupportAmerican College of SurgeonsCommittee on Trauma

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2003 Pediatric Advanced Life SupportAmerican Heart Association

LICENSURE

1987-1989 Massachusetts License, Number 57534 (inactive)

1989-1991 New York License, Number 178374 (inactive)

1991-present Ohio License, Number 61786

AWARDS AND HONORS

1974 New York State Regents Scholarship, Bronx High School of Science, New York, New York

1974-1978 Dean's List, Cornell University, Ithaca, New York

1977-1978 Honors Research Project, Cornell University, Department of Nutritional Sciences, Ithaca, New York Title: The Effect of Fatty Acids on Cell Mediated ImmunitySupervisor: Virginia Utermohlen, M.D.

1978 Magna Cum Laude with distinction in all subjectsCornell University, Ithaca, New York

1982 Alpha Omega Alpha Honor Medical SocietyUniversity of Cincinnati College of MedicineCincinnati, Ohio

1982 Citation for Scholastic AchievementAmerican Medical Women's Association

1987-1989 Pediatric Surgery Research Project: Novel Macrophage-Secreted Growth Factors Supervisors: M. Judah Folkman, MD and Michael Klasgsbrun, PhDFunding: National Cancer Institute Research Service AwardT 32 CA 09535-04

1990 Grand Prize Winner, American College of Surgeons (Western New York Chapter) Essay ContestTitle: Discovery of a Novel Macrophage-Derived Growth Factor

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1992 Research Award, Nationwide Children's Hospital Research Foundation Research Forum, Nationwide Children's Hospital, Columbus, OhioSpecial Commendation for Excellence in Research (DW)

1993 Research Award, Nationwide Children's Hospital Research Foundation Research Forum, Nationwide Children's Hospital, Columbus, OhioSpecial Commendation for Excellence in Research (RV)

1994 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioThird Prize Winner - Resident’s Paper Competition (DWM)

1996 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioSecond Prize Winner - Resident’s Paper Competition (RC)

1997 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioFirst Prize Winner - Resident’s Paper Competition (SP)

1997 Research Award, Annual Surgery Resident’s ForumHuntington, West VirginiaSecond Prize Winner - Resident’s Paper Competition (SP)

1997 Research Award, Nationwide Children's Hospital Research Foundation Research Forum, Nationwide Children's Hospital, Columbus, OhioFirst Prize Winner - Graduate Student Research Competition (RC)

1997 Research Award, Nationwide Children's Hospital Research Foundation Research Forum, Nationwide Children's Hospital, Columbus, OhioSecond Prize Winner - Graduate Student Research Competition (SP)

1997 Sterling Who’s Who

1998 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, Ohio First Prize Winner – Resident’s Paper Competition (SP)

1998 Strathmore’s Who’s Who

1999 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioSecond Prize Winner – Resident’s Paper Competition (CH)

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1999 Research Award, Fourth Annual Resident’s Research Conference, The Ohio State University College of Medicine, Columbus, OhioFirst Prize Winner – Resident’s Paper Competition (SP)

1999 Marquis’ Who’s Who in Medicine and Health Care

2000 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioFirst Prize Winner – Resident’s Paper Competition (MM)

2000 Research Award, Nationwide Children's Hospital Research Foundation Research Forum, Nationwide Children's Hospital, Columbus, OhioFirst Prize Winner - Graduate Student Research Competition (MM)

2000 Research Award, Nationwide Children's Hospital Research Foundation Research Forum, Nationwide Children's Hospital, Columbus, OhioThird Prize Winner - Graduate Student Research Competition (MLM)

2000 Recognition Award for Surgical Separation of Conjoined Twins from Africa, Liberian Friendship Association, Columbus, Ohio, Dec. 30, 2000.

2001 The Grant Morrow III Resident Fellow Research AwardNationwide Children’s Hospital Research Foundation Research ForumNationwide Children’s Hospital, Columbus, OhioFirst Place Winner (AK)

2001 Best Program Award, Advances in Pediatric Surgery, Ohio Medical Education Network, 2000-2001 Season

2001 Best Surgical Presentation Award, Advances in Pediatric Surgery, Ohio Medical Education Network, 2000-2001 Season

2002 The Communicator Award of Distinction, The Ohio State University Medical Center, Ohio Medical Education Network (OMEN)-TV: Advances in Pediatric Surgery

2004 Research Award, Nationwide Children’s Hospital Research Foundation Research Forum, Nationwide Children’s Hospital, Columbus, OhioFirst Place Winner Best Research Fellow (OE)

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2006 Research Award, Nationwide Children’s Hospital and Children’s Research Institute Research Forum, Nationwide Children’s Hospital, Columbus, Ohio. First Prize Winner-Resident Research Competition (DR)

2006 Nationwide Children’s Hospital Art in Science CompetitionNationwide Children’s Hospital, Columbus, OhioHonorable Mention

2007 Tech Ohio Top Contributors to the Advancement of Technology (TopCAT) AwardWinner in Outstanding Woman in Technology Category

2007 Health Care Heroes AwardBusiness First, Columbus, OhioProvider Category

2007 The Global Directory of Who’s Who

2007 Best Doctors in America

2008 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioBronze Medal Winner – Resident’s Paper Competition (AR)

2008 Research Award, Ohio State University Medical Center Research DayPost-doctoral Fellow Research Award (AR)

2008 Outstanding House Staff Publication AwardNationwide Children’s Hospital, Columbus, OhioAward Winner (OEA)

2008 Who’s Who “Honors Edition”

2008 Endowed ChairJohn E. Fisher Professor of Neonatal Research



2009 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioGold Medal Winner – Resident’s Paper Competition (AR)

2009 Research Award, Ohio State University Medical Center Research DayMedical Student Research Award (NO)

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2009 Research Award, The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, OhioPrize Winner (AR)

2009 Research Award, The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, OhioPrize Winner (XY)

2009 Strathmore’s Who’s Who

2009 Hero Recognition Award, Columbus Church of Christ


2010 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioGold Medal Winner – Resident’s Paper Competition (IO)

2010 Research Award, Ohio State University Medical Center Research DayPost-doctoral Fellow Research Award (AR)

2010 Ohio Chapter of the American College of SurgeonsSecond Place Prize – Clinical Category (IOJ)

2010 Annual International Symposium on Cells of the Hepatic Sinusoid, Pasadena, CAWinner – Trainee Travel Award Competition (GH)


2011 Research Award, 16th Annual Department of Surgery Research Conference, Ohio State University, Columbus, OhioThird Place Prize – (IOJ)

2011 James D. King Research Award, Department of SurgeryOhio State UniversityWinner (MM)


2012 Columbus Surgical Society, Columbus, OhioWinner – First Place Research Prize (DW)

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2012 Denis R. King Teacher of the Year Award for Outstanding Contributions to Surgical EducationNationwide Children’s Hospital, Columbus, Ohio

2012 Research Award, 17th Annual Department of Surgery Research Conference, Ohio State University, Columbus, OhioThird Place Prize – (MM)

2012 Career Contribution AwardNationwide Children’s Hospital, Columbus, Ohio


*2012 Rosencrantz Resident Research AwardAmerican Academy of Pediatrics Section on SurgeryBest Basic Science Research Award (MM)

2013 Research Award, 18th Annual Department of Surgery Research Conference, Ohio State University, Columbus, OhioSecond Place Prize – (MM)

2013 Research Award, The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, OhioPrize Winner (JW)

2013 James King Research Award, The Ohio State University Department of Surgery, Columbus, OhioPrize Winner (TR)

*2013 Rosencrantz Resident Research AwardAmerican Academy of Pediatrics Section on SurgeryBest Clinical Research Award (LB)


2014 BioMed Central Translational Research Award Winner for manuscript entitled “Enteric nervous system abnormalities are present in human necrotizing enterocolitis: potential neurotransplantation therapy”

2014 Research Award, 19th Annual Department of Surgery Research Conference, Ohio State University, Columbus, OhioFirst Place Prize for Best Poster – (TR)

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2014 Research Award, The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, OhioPrize Winner (YL)

2014 American College of Surgeons Young Fellow Mentorship ProgramMentee: Dr. Karen Woo, Assistant Professor of Surgery, University of California


*2014 Rosencrantz Resident Research AwardAmerican Academy of Pediatrics Section on SurgeryBest Poster Award (MR)

2015 Ohio State University Office of International AffairsTravel Award ($2000), H3C Health Science Innovation ConferenceMumbai, India

*2015 American Pediatric Surgical Association M. Judah Folkman Award for Best Clinical Research Podium PresentationPrize Winner (BC)

*2015 American College of Surgeons National Surgical Quality Improvement Program (NSQIP) MED-RES Abstract Competition AwardPrize Winner (BC)


2015 Fall Trainee Travel AwardResearch Institute at Nationwide Children’s HospitalAward Winner (JO)

2015 Special Faculty Award in recognition of Outstanding Faculty Performance and Academic Contributions ($6335)Ohio State University College of Medicine

*2015 Rosencrantz Resident Research AwardAmerican Academy of Pediatrics Section on SurgeryBest Basic Science Research Presentation Award (TR)

2016 Spring Trainee Travel AwardResearch Institute at Nationwide Children’s HospitalAward Winner (BC)

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2016 Best Manuscript by a New AAS MemberAcademic Surgical ConferenceAward Winner (BC)

2016 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioPlatinum Prize Winner - Resident’s Paper Competition (JO)

2016 Research Award, Presidential Symposium, Columbus Surgical Society, Columbus, OhioBronze Prize Winner - Resident’s Paper Competition (BC)

2016 Best Poster Award, Center for Regenerative Medicine and Cell Based Therapes 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, OhioBronze Prize Winner – Resident’s Poster Competition (BC)


2016 Research Poster Award, The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, OhioFirst Place Poster Award (SG)

2016 Fall Trainee Travel AwardThe Research Institute at Nationwide Children’s Hospital (CM)

2016 Medical Student Travel AwardThe Ohio State University College of Medicine (SG)

2016 Pediatric Medical Student Research Forum, Orlando, FL.Third Place Prize Winner – Student Research Competition (SG)

*2016 Rosencrantz Resident Research AwardAmerican Academy of Pediatrics Section on SurgeryBest Basic Science Research Presentation Award (CM)

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NATIONAL INSTITUTE OF HEALTH (NIH) REVIEW PANELS

2001-2004 Member, National Institute of General Medical Sciences Special Emphasis Review Panel for Postdoctoral Training Grants in Burns and Inflammation.

2002-2004 Member, National Institute of General Medical Sciences Special Emphasis Review Panel for Research Center Grants in Trauma, Burns and Perioperative Injury

2003-2004 Member, National Institute of General Medical SciencesReview Group for National Institute of Health Loan Repayment Program (LRP) Applications

2004-2008 Full-time Member, Surgery, Anesthesia and Trauma (SAT) Study Section, National Institutes of Health

2009 Reviewer, NIH Challenge Grants, Special Emphasis Panel/Scientific Review Group 2009/10 ZRG1 SBIB-V

2010 Reviewer, NIH Challenge Grants, Special Emphasis Panel/Scientific Review Group 2010/08 ZRG1 ENMR-C (55)

NATIONAL INSTITUTE OF HEALTH (NIH) COUNCILS

2013-2016 Member, National Institute of General Medical SciencesNational Advisory Council

PATENTS AWARDED

1. Klagsbrun M, Abraham J, Higashiyama S, Besner G: Heparin-binding Mitogen with Homology to EGF. U.S. Patent No. 5811393. Date filed 6/15/93.

2. Klagsbrun M, Abraham J, Higashiyama S, Besner G: Heparin-binding Mitogen with Homology to EGF. European Patent Application No. 92900987.6. Date filed 10/16/91.

3. Klagsbrun M, Abraham J, Higashiyama S, Besner G: Heparin-binding Mitogen with Homology to EGF. Australian Patent No. 663298. Date filed 10/16/91.

4. Klagsbrun M, Abraham J, Higashiyama S, Besner G: Heparin-binding Mitogen with Homology to EGF. Canadian Patent No. 2094045. Date filed 10/16/91.

5. Besner G, Pillai S: Methods of Treating Intestinal Ischemia Using Heparin-Binding Epidermal Growth Factor. U.S. Patent No. 6387878. Date filed 10/29/98.

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6. Besner G, El-Assal O: HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resuscitation. U.S. Patent No. 2008/134635.

7. Besner G: Method of Treating Necrotizing Enterocolitis Using Heparin Binding Epidermal Growth Factor. U.S. Patent No. 2010/042821.

PATENTS PENDING

1. Besner G: Administration of Heparin Binding Epidermal Growth Factor for the Protection of Enteric Neurons. Application no. 12/872,961. Filed 8/31/10.

2. Besner G: Methods of Treating Intestinal Injury using Heparin-Binding Epidermal Growth Factor and Stem Cells. Filed 2/22/12.

3. Besner G: Production of Tissue Engineered Intestine. Filed April 2012.

PROFESSIONAL ORGANIZATIONS

International and National

Academy of Surgical Research1995-present Member (ASR06)

Alpha Omega Alpha Honor Medical Society1982-present Member

American Academy of Pediatrics 1992-present Specialty Fellow, Surgical Section (ID#160655)2000-2003 Member, Scientific Program Committee2001-2002 Co-Chair, Scientific Program Committee2002-2003 Chair, Scientific Program Committee2012-present Chair, Liaison and Advocacy Committee2015-present Member, Executive Committee

American Association for the Advancement of Science1993-present Member

American Burn Association1993-present Member (#10384)

American Burn Life Support Instructor1993-present Instructor

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American College of Surgeons 1983-1990 Candidate Member1991-1994 Associate Fellow1994-present Fellow (03003460)2007-present Member, Surgical Research Committee2008-present Member, Executive Committee of the Surgical Research Committee2009-present Grading Team Member, Surgical Forum Committee2011-2013 Vice-Chair, Surgical Research Committee2013-2015 Chair, Surgical Research Committee2015-2017 Ad Hoc Member, Scientific Forum Committee, Pediatric Surgery

American Gastroenterological Association1997-present Member

American Medical Association1982-present Member (ME#03841820168)

American Medical Women’s Association1982-present Member

American Pediatric Surgical Association1994-present Member1999-2003 Member, Critical Care Committee2003-2004 Chair, Nominating Committee2003-2006 Member, Publications Committee2004 Member, Task Force on Family Issues2009-2012 Member, Program Committee2012-2015 Member, Credentialing and Membership Committee2013-2016 Member, Audit Committee2014-2015 Chair, Nominating Committee2015-pres Member, Advocacy Committee2015-pres Vice Chair, Research Committee2016-2019 Member, Board of Governors

American Pediatric Surgical Association Foundation2012-2015 At-Large Member

The American Society for Cell Biology1993-present Member (#6378)

American Surgical Association2009 Induction

Association for Academic Surgery1992-present Member

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Association of Pediatric Surgery Training Program Directors (APSTPD)2009-present Member2013 Member, Nominating Committee

British Association of Pediatric Surgeons1998-present Member

Children's Cancer Group (now Children’s Oncology Group) 1993-present Member, Surgery Discipline Committee1993-2001 Hospital Representative1994-1996 Member, Biologic Research Committee1996-1998 Member, Young Investigators Committee1998–1999 Member, Transition Team for the New Pediatric Cooperative Group

Cornell University Alumni Association1978-present Member

Federation of American Societies for Experimental Biology1993-present Member

National Association of Medical Scientist Training Program Directors1999-2001 Member

Pediatric Surgery Biology Club1992-1997 Member

Pediatric Trauma Society2015 - present

Robert M. Zollinger Surgical Society1991-present Member

Society of Critical Care Medicine1992-present Member

Society for Pediatric Research2001-present Member

Society of Surgical Oncology1995-present Member

Society of University Surgeons1996-present Member2000 Invited Participant, Membership Committee2001-2004 Member, Committee on Social and Legislative Issues2007-present Ohio State University Institutional Representative2007-2010 SUS Foundation At-Large Member

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The Wound Healing Society1997-present Member

PROFESSIONAL ORGANIZATIONS

State and Local

1974-present Bronx High School of Science Alumni Association

1982-1987 Massachusetts Medical Association

1992-present Columbus Surgical Society

1992-present Central Ohio Pediatrics Society

1992-present Ohio State Medical Association

1992-present Academy of Medicine of Columbus and Franklin County

1994-present The Ohio State University Pediatric Oncology Program

ADMINISTRATIVE ACTIVITIES

National

1993-2000 Cancer Liaison OfficerAmerican College of Surgeons Commission on Cancer

1993-2001 Children's Cancer Group Hospital RepresentativeNationwide Children's Hospital, Columbus, Ohio

1995-1998 American Board of Surgery In-Training/Surgical Basic Science Examination Committee

1999-2003 American Pediatric Surgical AssociationMember, Critical Care Committee

2000 Society of University SurgeonsMembership Committee, invited participant

2001-2003 American Academy of Pediatrics, Surgical SectionMember, Scientific Program Committee

2001 Society of University SurgeonsProgram Committee, invited participant

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2001-2004 Society of University SurgeonsMember, Committee on Social and Legislative Issues

2001-2002 American Academy of Pediatrics, Surgical SectionCo-Chair, Scientific Program Committee

2002-2003 American Academy of Pediatrics, Surgical SectionChair, Scientific Program Committee

2003-2004 American Pediatric Surgical AssociationChair, Nominating Committee

2003-2006 American Pediatric Surgical AssociationMember, Publications Committee

2003-2010 Board Examiner for Pediatric Surgery Oral BoardsThe American Board of Surgery

2007-present Society of University SurgeonsOhio State University Institutional Representative

2007-present Society of University SurgeonsSUS Foundation At-Large Member

2007-2011 American College of SurgeonsMember, Surgical Research CommitteeMember, Executive Committee of the Surgical Research Committee

2009-present Grading Team Member, Surgical Forum CommitteeAmerican College of Surgeons

2009-present American Pediatric Surgical AssociationMember, Program Committee

2009-present Association of Pediatric Surgery Training Program DirectorsMember

2011-2013 American College of SurgeonsVice-Chair, Surgical Research Committee

2011-2015 Pediatric Surgery In-training Examination Committeeof the American Board of SurgeryConsultant

2012-present American Pediatric Surgical Association FoundationAt-Large Member

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2012-present American Academy of Pediatrics, Surgical SectionChair Advocacy and Liaison Committee

2012-2015 American Academy of PediatricsMember, Credentialing and Membership Committee

2013-2015 American College of SurgeonsChair, Surgical Research Committee

2013-2016 American Pediatric Surgical AssociationMember, Audit Committee

2014 American Pediatric Surgical AssociationChair, Nominating Committee

2015-2017 American College of SurgeonsAd Hoc Member, Scientific Forum Committee, Pediatric Surgery

2015 American Academy of Pediatrics, Section on SurgeryMember, Executive Committee

2015 American Pediatric Surgical AssociationMember, Advocacy Committee

2015 American Pediatric Surgical AssociationVice Chair, Research Committee

2016-2019 American Pediatric Surgical AssociationMember, Board of Governors

ADMINISTRATIVE ACTIVITIES

University Services

1991-1993 Coordinator for Medical Student EducationNationwide Children's Hospital, Columbus, Ohio

1991-1994 Same Day and Ambulatory Surgery Subcommittee of theOperating Room Committee, Nationwide Children's HospitalColumbus, Ohio

1991-present Member, Pediatric Surgery Resident Admission CommitteeDepartment of Surgery, Nationwide Children's Hospital, Columbus, Ohio

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1991-present Member, General Surgery Resident Admission CommitteeDepartment of Surgery, The Ohio State UniversityColumbus, Ohio

1991-present Director of Pediatric Surgical ResearchNationwide Children's Hospital, Columbus, Ohio

1991-1997 Comprehensive Cancer Care CommitteeNationwide Children's Hospital, Columbus, Ohio

1991-1996 Program Committee, Nationwide Children's Hospital Research Foundation, Nationwide Children's Hospital, Columbus, Ohio

1992-1994 Library Committee, Nationwide Children's Hospital, Columbus, Ohio

1992-1994 Computer Acquisition Review CommitteeNationwide Children's Hospital, Columbus, Ohio

1993-1994 Special Procedures Subcommittee of Operating Room Committee, Nationwide Children's Hospital, Columbus, Ohio

1993-1994 Disaster Committee, Nationwide Children's Hospital, Columbus, Ohio

1993-1994 Medical Staff Information Services CommitteeNationwide Children's Hospital, Columbus, Ohio

1993-1994 Interdisciplinary Ambulatory Services Quality Improvement Committee, Nationwide Children's Hospital, Columbus, Ohio

1993-1995 Human Subjects Committee Internal Review BoardNationwide Children's Hospital, Columbus, Ohio

1993-2009 Burn Director, Nationwide Children's Hospital, Columbus, Ohio

1993-1997 Co-Director for Medical Student EducationNationwide Children's Hospital, Columbus, Ohio

1993-1998 Burn/Trauma Unit Triad PhysicianNationwide Children's Hospital, Columbus, Ohio

1994 First Case Delay Subcommittee of Operating Room CommitteeNationwide Children's Hospital, Columbus, Ohio

1995-1998 Member, Medical Scientist Program Admission Committee, The Ohio State University College of Medicine, Columbus, Ohio

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1996-1997 Member, Case Management Team CommitteeNationwide Children's Hospital, Columbus, Ohio

1996-1997 Member, Nissen Fundoplication Review CommitteeNationwide Children's Hospital, Columbus, Ohio

1996-1997 Member, Appendectomy Review CommitteeNationwide Children's Hospital, Columbus, Ohio

1996-1997 Member, Critical Care Division Search CommitteeNationwide Children's Hospital, Columbus, Ohio

1997-present Member, Graduate Studies Committee, The Ohio State University Department of Surgery, Columbus, Ohio

1998-2002 Member, American Cancer Society, Institutional Research Grant Committee, The Ohio State University, Columbus, Ohio

1999-2001 Co-Director, Medical Scientist ProgramThe Ohio State University College of Medicine, Columbus, Ohio

2001-present Member, College of Medicine Research Scholarship Review Committee, The Ohio State University College of Medicine, Columbus, Ohio

2003-2004 Member, Division of Gastroenterology Search CommitteeNationwide Children's Hospital, Columbus, Ohio

2003-present Promotion and Tenure Committee, Department of SurgeryThe Ohio State University College of Medicine, Columbus, Ohio

2003-present Member, Pediatric Residency Research Pathway Interview Committee, Department of PediatricsThe Ohio State University College of Medicine, Columbus, Ohio

2005-present Member, Trauma Executive CommitteeNationwide Children’s Hospital, Columbus, Ohio

2005 Member, Pediatric Chief Review CommitteeNationwide Children’s Hospital, Columbus, Ohio

2005 Member, Graduate Medical Education CommitteeNationwide Children’s Hospital, Columbus, Ohio

2006 Member, Planning Committee for Design of the new Children’s Hospital, Nationwide Children’s Hospital, Columbus, Ohio

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2007-2012 Member, NICHD Child Health Research Center Internal Advisory Committee, Nationwide Children’s Hospital, Columbus, Ohio

2007-present Member, Scholarship Oversight CommitteeNationwide Children’s Hospital, Columbus, Ohio

2007-2009 Co-Chair, Pediatric Plastic Surgery Chief Search Committee,Nationwide Children’s Hospital, Columbus, Ohio

2009-present Member, Graduate Medical Education Committee,Nationwide Children’s Hospital, Columbus, Ohio

2009-present Associate Burn DirectorNationwide Children’s Hospital, Columbus, Ohio

2012-present Member, Surgical Chief’s CommitteeNationwide Children’s Hospital, Columbus, Ohio

2012-present Member, Perioperative CouncilNationwide Children’s Hospital, Columbus, Ohio

2012-2013 Chair, Pediatric Orthopedic Surgery Chief Search Committee,Nationwide Children’s Hospital, Columbus, Ohio

2013-present Member, Ohio State University Department of SurgeryExecutive Committee, Columbus, Ohio

2013-present Member, Mechnisms of Human Health and Disease Program (summer program for high school youth who excel in science), Application Review Panel, Nationwide Children’s Hospital, Columbus, Ohio

2014-present Member, Center for Clinical and Translational Science (CCTS) Advisory Board, The Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio

2014-present Member, Pediatric Surgery Training Program Clinical Competency Committee, Nationwide Children’s Hospital, Columbus, Ohio

2014-present Member, Pediatric Surgery Training Program, Program Evaluation Committee, Nationwide Children’s Hospital, Columbus, Ohio

2016-present Member, Ohio State University Department of Surgery Research Council, Columbus, Ohio

2016-present Member, US News and World Report Committee for Gastroenterology and GI Surgery, Nationwide Childen’s Hospial, Columbus, Ohio

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NATIONAL / INTERNATIONAL COURSES DEVELOPED AND MODERATED

Curriculum VitaeGAIL ELLEN BESNER, M.D.CLINICAL TEACHING ACTIVITIES

Operations Performed 400 (average per year)

Outpatient Visits 2500 (average per year)

Admissions 350 (average per year)

Hospital Consults 300 (average per year)

EDITORSHIP OF JOURNALS

Managing Editor: E Medicine, Textbook of Pediatric Surgery

Ad hoc reviewer for: Journal of Pediatric SurgeryJournal of Investigative SurgeryAmerican Journal of PhysiologyAmerican Journal of PathologyNitric Oxide: Biology and ChemistrySurgeryAmerican Journal of Obstetrics and GynecologyJournal of the American College of SurgeonsJournal of Burn Care and RehabilitationCell ProliferationAmerican Journal of PerinatologyPediatricsPediatric Research

Guest Editor for: Seminars in Pediatric Surgery“Progress in Pediatric Surgical Research” March 2004

1) International Web Course on Necrotizing Enterocolitis, Course Moderators: Gail Besner and Todd Ponsky, Nationwide Children’s Hospital and Rainbow Babies Hospital, Cleveland, Ohio, June 17, 2010. Attendees of this course were from the following countries: United States, Argentina, Australia, Bahrain, Brazil, Canada, Chile, Colombia, El Salvador, Germany, Greece, Kuwait, Netherlands, Peru, Puerto Rico, Qatar, South Africa, Spain, Sweden, Thailand.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.CURRENT GRANT SUPPORT

Title: Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis

Principal Investigator: Gail E. Besner, M.D.Funding Period: January 12, 2015 – December 31, 2018Funding Source: National Institutes of Health

Grant # 1 R01 GM113236Amount: $1,136,200

Title: Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis

Mentor: Gail E. Besner, M.D.Funding Period: July 1, 2015 – December 31, 2017Funding Source: NIH Research Supplement to Promote Diversity in Health-

Related Research – Parent Grant # 1 R01 GM113236Amount: $282,141

Title: HB-EGF Therapy for Necrotizing EnterocolitisPrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 2013 – December 31, 2017 Funding Source: The Research Institute at Nationwide Children’s HospitalAmount: $1,000,000

Title: Probiotics and HB-EGF: A Novel Therapy for Necrotizing Enterocolitis

Mentor: Gail E. Besner, M.D.Funding Period: April 1, 2015 – March 31, 2017Funding Source: American College of Surgeons Resident Research Fellowship

(to Dr. Jacob Olson)Amount: $60,000

Title: Necrotizing Enterocolitis Surgery Trial (NEST)Principal Investigator: Marty Blakely, M.D.Site PI: Gail E. Besner, M.D.Funding Period: September 1, 2011 – ongoingFunding Source: National Institutes of Health

Title: A Double-Blind, Placebo-Controlled, Multicenter Study With an Open-Label Extension to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients With Duchenne Muscuar Dystrophy

Principal Investigators: Jerry Mendell, MDRole: Sub-InvestigatorFunding Source: Sarepta Therapeutics, Inc.

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Title: Tuneable Native Probiotic Formulations to Study and Treat Necrotozing Enterocolitis

Principal Investigators: Gail E. Besner, MD, Seven Goodman, PhD, Michael Bailey, PhD.

Funding Period: April 1, 2017 – March 31, 2022Funding Source: NIH R01 GM123482Amount: $3,500,000

PENDING GRANT SUPPORT

Title: A Novel Probiotic Platform to Treat Necrotizing EnterocolitisPrincipal Investigators: Gail E. Besner, M.D. and Steven Goodman, PhDFunding Period: January 2017 – Sept 2017 Funding Source: NIH STTRAmount: $280,000

Title: The Role of Biofilm in Burn WoundsPrincipal Investigators: Chandan Sen, Ph.D.Site PI: Gail E. Besner, MDFunding Period: Oct 2016 – Sept 2021Funding Source: NIH P50Amount: $10,000,000

PREVIOUS GRANT SUPPORT

Title: A Novel Macrophage-Secreted Growth Factor and its Role in Wound Healing and Atherosclerosis

Principal Investigator: Gail E. Besner, M.D.Funding Period: July 1991 - December 1992Funding Source: Columbus Children's Hospital Research FoundationAmount: $75,000

Title: Heparin-Binding EGF-Like Growth Factor (HB-EGF): Expression, Isolation and Clinical Applications

Principal Investigator: Gail E. Besner, M.D.Funding Period: December 1991 - November 1992Funding Source: Bremer Foundation Research Grant Amount: $5,000

Title: Heparin-Binding EGF-Like Growth Factor (HB-EGF): Expression, Isolation and Clinical Applications

Principal Investigator: Gail E. Besner, M.D.Funding Period: January 1992 - December 1992Funding Source: Ohio State University Seed GrantAmount: $7,500

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Title: Preparation of Anti-HB-EGF AntibodiesPrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1992 - December 1992Funding Source: Ohio State University, Department of Surgery

Medical Research and Development Fund GrantAmount: $5,000

Title: A Novel Macrophage-Secreted Growth Factor and its Role in Wound Healing

Principal Investigator: Gail E. Besner, M.D.Funding Period: July 1992 - June 1994Funding Source: American College of Surgeons

Faculty Fellowship AwardAmount: $60,000

Title: Molecular Cloning and Biological Characterization of Heparin-Binding EGF-Like Growth Factor

Principal Investigator: Gail E. Besner, M.D.Funding Period: January 1993 - December 1993Funding Source: Columbus Children's Hospital Research Foundation Amount: $60,526

Title: HB-EGF Localization in the Burn WoundPrincipal Investigator: Gail E. Besner, M.D.Funding Period: May 1993 - April 1994Funding Source: Ohio State University, Department of Surgery


Title: Characterization of a Novel Growth Factor in Human Urine

Principal Investigator: Gail E. Besner, M.D.Funding Period: October 1993 - September 1994Funding Source: Ohio State University, Department of Surgery


Title: A Novel Heparin-Binding Growth Factor in Uterine FluidPrincipal Investigator: David Brigstock, Ph.D.Co-Investigator: Gail E. Besner, M.D. Funding Period: December 1993 - November 1998Funding Source: National Institutes of Health

Grant # 1 R29 HD30334Amount: $350,000

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Principal Investigator: Gail E. Besner, M.D.Funding Period: January 1994 - December 1994Funding Source: Columbus Children's Hospital Research FoundationAmount: $59,000

Title: Localization and Cytoreduction of Occult NeuroblastomaPrincipal Investigator: M. Sue O'DorisioCo-investigator: Gail E. Besner, M.D. Funding Period: January 1994 - June 1997Funding Source: American Cancer SocietyAmount: $396,018

Title: Production of HB-EGF Transgenic MousePrincipal Investigator: Gail E. Besner, M.D.Funding Period: July 1994 - June 1995Funding Source: The Ohio State University

Davis Medical Research GrantAmount: $18,000


Principal Investigator: Gail E. Besner, M.D.Funding Period: January 1995 - December 1995Funding Source: Columbus Children's Hospital Research FoundationAmount: $55,049

Title: The Role of HB-EGF in Burn Wound HealingPrincipal Investigator: Randolph K. Cribbs, M.D.Sponsor: Gail E. Besner, M.D.Funding Period: March 1, 1995 - February 28, 1997Funding Source: National Institutes of Health

National Research Service Award Fellowship # GM 17449

Amount: $58,500

Title: An Analysis of the Functional Significance of HB-EGF Glycosylation

Principal Investigator: Gail E. Besner, M.D.Funding Period: September 1, 1995 - June 30, 1996Funding Source: American Cancer Society

Starter Cancer Research GrantAmount: $12,000

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Title: Structural and Functional Studies of Heparin-Binding EGFPrincipal Investigator: Gail E. Besner, M.D.Funding Period: September 1, 1995 - August 31, 2000Funding Source: National Institutes of Health

Grant # 1 R29 GM50905-01Amount: $350,000

Title: Structural and Functional Studies of Heparin-Binding EGFPrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 1996 - December 31, 1996Funding Source: Columbus Children's Hospital Research FoundationAmount: $12,019

Title: Production and Analysis of HB-EGF Transgenic MicePrincipal Investigator: Gail E. Besner, M.D.Funding Period: June 1, 1996 - May 30, 1997Funding Source: Ohio State University, Department of Surgery


Title: Production and Analysis of HB-EGF Transgenic MicePrincipal Investigator: Gail E. Besner, M.D.Funding Period: July 1, 1996 - June 30, 1997Funding Source: Columbus Children's Hospital Research FoundationAmount: $20,459

Title: Structural and Functional Studies of HB-EGFPrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 1997 - December 31, 1997Funding Source: Columbus Children's Hospital Research FoundationAmount: $13,162

Title: Production and Analysis of HB-EGF Transgenic and Knockout Mice

Principal Investigator: Gail E. Besner, M.D.Funding Period: July 1, 1997 - June 30, 1998Funding Source: Columbus Children's Hospital Research FoundationAmount: $41,221

Title: Structural and Functional Studies of HB-EGFPrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 1998 - December 31, 1998Funding Source: Columbus Children's Hospital Research FoundationAmount: $19,738

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Title: Preclinical Trials of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in the Treatment of Intestinal Ischemia/Reperfusion Injury

Principal Investigator: Gail E. Besner, M.D.Funding Period: June 1, 1998 – May 31, 1999Funding Source: American Pediatric Surgical Association FoundationAmount: $7,500

Title: HB-EGF Treatment of Intestinal Ischemia/Reperfusion InjuryPrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 2000 - December 31, 2000Funding Source: Columbus Children's Hospital Research FoundationAmount: $50,207

Title: The Role of Nitric Oxide in the Mechanism of HB-EGF Cytoprotection

Principal Investigator: Gail E. Besner, M.D.Funding Period: July 1, 2000 - June 30, 2001Funding Source: Medical Research Development Fund, Department of Surgery,

Ohio State University College of MedicineAmount: $10,000

=Title: HB-EGF Treatment of Intestinal Ischemia/Reperfusion InjuryPrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 2001 - December 31, 2001Funding Source: Children's Research InstituteAmount: $67,786

Title: HB-EGF and Intestinal Ischemia/Reperfusion Principal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 2002 – December 31, 2006Funding Source: National Institutes of Health

Grant # 1 R01 GM61193Amount: $750,000

Title: Role of NO and Endothelin in Human NECPrincipal Investigator: Gail E. Besner, MDFunding Period: July 1, 2003 – June 30, 2011Funding Source: National Institutes of Health

Grant # 1 R01 DK65306Amount: $1,250,000

Title: HB-EGF and Protection of the Intestines from Injury Principal Investigator: Gail E. Besner, M.D.Funding Period: March 1, 2006 – February 28, 2008Funding Source: Trillium Therapeutics, Inc.Amount: $400,000

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Title: HB-EGF Expression and Function in Human NECPrincipal Investigator: Heather Paddock, M.D.Mentor: Gail E. Besner, M.D.Funding Period: July 1, 2006 –June 30, 2008Funding Source: Children's Research Institute Patient Oriented Research AwardAmount: $50,000

Title: HB-EGF and Intestinal Ischemia/Reperfusion Principal Investigator: Gail E. Besner, M.D.Funding Period: May 1, 2007 – April 30, 2012 Funding Source: National Institutes of Health

Grant # 2 R01 GM61193-05Amount: $1,180,800

Title: HB-EGF and Protection of the Intestines from Injury Principal Investigator: Gail E. Besner, M.D.Funding Period: April 1, 2008 – March 31, 2009Funding Source: Trillium Therapeutics, Inc.Amount: $150,000

Title: HB-EGF and Intestinal Ischemia/Reperfusion Principal Investigator: Iyore Otabor, M.D.Funding Period: July 1, 2008 – June 30, 2010 Funding Source: National Institutes of Health

Grant # 3R01GM061193-06S1NIH Diversity Award

Amount: $161,280Role: Mentor

Title: Fetal Origins of Necrotizing Enterocolitis Principal Investigator: Peter Giannone, M.D.Funding Period: July 1, 2008 – June 30, 2011Funding Source: March Of Dimes FoundationAmount: $300,000Role: Co-Investigator

Title: Novel Therapeutic Targets in Necrotizing EnterocolitisPrincipal Investigator: Peter Giannone, M.D.Mentor: Gail E. Besner, M.D.Funding Period: Feb 1, 2008 – Jan 31, 2013Funding Source: National Institutes of Health

Grant #K23 DK078909Amount: $791,215

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Title: HB-EGF Therapy for Necrotizing Enterocolitis Principal Investigator: Gail E. Besner, M.D.Funding Period: June 1, 2007 – May 31, 2013Funding Source: National Institutes of Health

Grant # 1 R01 DK074611Amount: $1,800,000

Title: Production of Tissue Engineered IntestinePrincipal Investigator: Gail E. Besner, M.D.Funding Period: June 1, 2013 – June 4, 2014 Funding Source: Technology Development Fund Grant

The Research Institute at Nationwide Children’s HospitalAmount: $50,000

Title: Production of Tissue Engineered IntestinePrincipal Investigator: Gail E. Besner, M.D.Funding Period: January 1, 2014 – December 31, 2014 Funding Source: Ohio Third Frontier Technology Validation and Start-Up Fund

(TVSF) GrantAmount: $100,000

Title: HB-EGF and Intestinal Ischemia/Reperfusion Principal Investigator: Gail E. Besner, M.D.Funding Period: Sept 30, 2011 – May 31, 2016 Funding Source: National Institutes of Health

Grant # 2 R01 GM61193-05Amount: $1,245,280

Title: Tissue Engineered IntestineCo-Investigator: Gail E. Besner, M.D.Funding Period: July 1, 2015 – December 31, 2015Funding Source: NIH R43DK107168-01Amount: $244,999

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Curriculum VitaeGAIL ELLEN BESNER, M.D.PEDIATRIC SURGICAL RESIDENTS TRAINED

7/1/91 - 6/30/92 Dan Teitelbaum, M.D.Current Position: Professor of SurgeryUniversity of MichiganC. S. Mott Children's HospitalAnn Arbor, Michigan

7/1/91 - 6/30/93 Jonathan Groner, M.D.Current Position: Professor of Clinical SurgeryThe Ohio State UniversityNationwide Children’s HospitalColumbus, Ohio

7/1/92 - 6/30/94 John Gosche, M.D.Current Position: Professor of SurgeryUniversity of Las VegasLas Vegas, Nevada

7/1/93 - 6/30/95 Denis Bensard, M.D.Current Position: Professor of Surgery University of ColoradoDenver, CO

7/1/94 - 6/30/96 Nashith Bhattacharyya, M.D.Current Position: Professor of Surgery University of Medicine and Dentistry of New JerseyNewark, New Jersey

7/1/95 - 6/30/97 Colin Bethel, M.D.Current Position: Professor of SurgeryUniversity of Medicine and Dentistry of New JerseyNewark, New Jersey

7/1/96 - 6/30/98 Khaled Mutabagani, M.D.Current Position: Attending Pediatric SurgeonKing Abduzaiz University, New Jeddah Clinic HospitalJeddah, Saudi Arabia

7/1/97 - 6/30/99 Ravindra Vegunta, M.D.Current Position: Professor of SurgeryUniversity of PhoenixPhoenix, AZ

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7/1/98 - 6/30/00 Diane W. McCarthy, M.D.Current Position: Attending Pediatric SurgeonInland Pediatric Surgical AssociatesSpokane Pediatric SpecialistsSpokane, Washington

7/1/99 - 6/30/01 Mark Downing, M.D.Current Position: Attending Pediatric SurgeonBronson Health SystemKalamazoo, Michigan

7/1/00 - 6/30/02 Marc Michalsky, M.D.Current position: Professor of SurgeryThe Ohio State UniversityNationwide Children’s HospitalColumbus, Ohio

7/1/01 - 6/30/03 Ann O’Connor, M.D.Current position: Associate Professor of Surgery Lurie Children’s HospitalChicago, IL

7/1/02 - 6/30/04 Cynthia Corpron, M.D.Current position: Attending Pediatric SurgeonSyracuse UniversitySyracuse, New York

7/1/03 - 6/30/05 Sanjay Krishnaswami, M.D.Current position: Associate Professor of SurgeryUniversity of OregonPortland, OR

7/1/04 - 6/30/06 Shahab Abdessalam, M.D.Current position: Professor of SurgeryUniversity of NebraskaOmaha, NE

7/1/05 - 6/30/07 Lindsay Grier Arthur, M.D.Current position: Associate Professor of SurgerySt. Christopher’s HospitalPhiladelphia, PA

7/1/06 - 6/30/08 Jeffrey Halter, M.D.Current Position: Associate Professor of SurgeryMaine Medical CenterPortland, Maine

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7/1/07 - 6/30/09 Jennifer Aldrink, M.D.Current position: Assistant Professor of SurgeryNationwide Children’s HospitalColumbus, Ohio

7/1/08 - 6/30/10 Dorothy Rocourt, M.D.Current Position: Assistant Professor of SurgeryPenn State UniversityHershey, PA

7/1/09 - 6/30/11 David Scarda, M.D.Current Position: Assistant Professor of SurgeryPrimary Children’s HospitalSalt Lake City, UT

7/1/10 – 6/30/12 Helena Crowley, M.D.Current Position: Assistant Professor of SurgerySt. Christopher’s Hospital for ChildrenPhiladelphia, PA

7/1/11-6/30/13 Johanna Askegard-Giesmann, M.D.Current Position: Assistant Professor of SurgeryJ. W. Riley Hospital for ChildrenIndianapolis, IN

7/1/12 – 6/30/14 Mehul Raval, M.D.Current Position: Assistant Professor of SurgeryEmory University, Children’s Healthcare of AtlantaAtlanta, GA

7/1/13 – 6/30/15 Rejan Thakkar, M.D.Current Position: Assistant Professor of SurgeryNationwide Children’s Hospital, Columbus, OH

7/1/14 – 6/30/16 Paysam Sadaii, M.D.Current Position: Assisant Professor of SurgeryThe Children’s Hospital at UC Davis, Sacramento, CA

7/1/15 – 6/30/17 Lorraine Kelly-Quon, M.D.Current Position: in training

8/1/16 – 7/31/18 Jeremy Fisher, M.D.Current Position: in training

8/1/17 – 7/31/19 Justin huntington, M.D.Current Position: in training

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Curriculum VitaeGAIL ELLEN BESNER, M.D. SURGICAL CRITICAL CARE FELLOWS TRAINED

7/1/02 – 6/30/03 Robert Gates, M.D.Current position: Faculty member, Greenville Hospital System University Medical Center, Greenville, SC

7/1/03 - 6/30/04 Shahab Abdessalam, M.D.Current position: Professor of SurgeryUniversity of Nebraska, Omaha, NE

7/1/04 - 6/30/05 Anthony Georges, M.D.Current position: Faculty member, Lehigh Valley Health Network, Allentown, PA

7/1/05 - 6/30/06 Heather Paddock, M.D.Current position: Assistant Professor of SurgeryUniversity of Illinois, Chicago, IL

7/1/06 - 6/30/07 Chad Hamner, M.D.Current position: Trauma Director, Cook Children’s Hospital, Fort Worth, TX

7/1/07 - 6/30/08 Dorothy Rocourt, M.D.Current position: Assistant Professor of SurgeryPennsylvania State UniversityHershey, PA

7/1/08 - 6/30/09 Angela Hanna, M.D.Current position: Faculty member, Cook Children’s Hospital, Fort Worth, TX

7/1/09 - 6/30/10 Johanna Askegard-Giesmann, M.D.Current position: Assistant Professor of SurgeryJ. W. Riley Hospital for ChildrenIndianapolis, IN

7/1/10 - 6/30/11 Thomas Sims, M.D.Current position: In training

7/1/11 - 6/30/12 Katherine Dominguez, M.D.Current position: In training

7/1/12 – 6/30/13 Keith Webb, M.D.Current position: In training

7/1/13 – 6/30/14 Laua Boomer, M.D.Current position: In training

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7/1/14 – 6/30/15 Jason Nielson, M.D.Current position: In training

7/1/15-6/30/16 Lindsay Talbot, M.D.Current position: In training

POSTDOCTORAL FELLOWS SUPERVISED (M.D., M.D./PH.D.)

7/1/91 - 6/30/93 Ravindra Vegunta, M.D.Project: Heparin-binding EGF-like growth factor and its role in atherosclerosisCurrent Position: Professor of SurgeryUniversity of PhoenixPhoenix, AZ

7/1/91 - 6/30/94 Diane McCarthy, M.D.Projects: Analysis of human burn wound fluid for heparin-binding growth factors; Production of anti-HB-EGF antibodies; Identification of a novel growth factor in urine Current Position: Attending Pediatric SurgeonInland Pediatric Surgical AssociatesSpokane Pediatric SpecialistsSpokane, Washington

7/1/93 - 6/30/95 Mark Downing, M.D.Project: HB-EGF immunohistochemistry in normal and pathologic tissuesCurrent Position: Attending Pediatric SurgeonBronson Health SystemKalamazoo, Michigan

7/1/94 - 6/30/96 Randolph Cribbs, M.D.Projects: A Study of the role of HB-EGF in burn wound healing; Production of a murine partial-thickness burn wound modelCurrent Position: Attending Surgeon, Los Alamos, NM

2/1/94 - 2/18/97 Paul Harding, Ph.D.Projects: Production of an HB-EGF transgenic mouse; Production of an HB-EGF knockout mouseCurrent Position: Professor and Chair, Department of Biological Sciences Cell, Molecular, and Structural Biology ProgramUniversity of Miami, Oxford, Ohio

7/1/96 - 6/30/98 Sri Pallai, M.D.

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Project: A study of the effects of HB-EGF on prevention and treatment of intestinal ischemia Current Position: Associate Professor of SurgeryCook County Hospital, Chicago, Illinois

7/1/97 - 6/30/99 Christina Hinman, M.D.Project: A study of the effects of HB-EGF in a model of intestinal ischemia/reperfusion injuryCurrent Position: Attending Pediatrician, Minneapolis, Minnesota

7/1/98 - 6/30/99 Marc Downing, M.D.Project: Production of a neonatal model of intestinal ischemia/reperfusion injuryCurrent Position: Attending Pediatric SurgeonBronson Health System, Kalamazoo, Michigan

7/1/99 - 6/30/00 Marc Michalsky, M.D.Project: A study of the effects of HB-EGF on apoptosis and oxygen free radical productionCurrent position: Associate Professor of SurgeryNationwide Children’s Hospital, Columbus, Ohio

9/15/99 - 12/31/00 Maria Lara-Marquez, M.D., Ph.D.Project: A study of the effects of HB-EGF on iNOS and NO production in intestinal epithelial cellsCurrent Position: Associate ProfessorCentral University of VenezuelaVenezuela, South America

12/1/99 - 12/1/01 Guliang Xia, M.D., Ph.D.Project: A study of the effects of HB-EGF on iNOS, NO, OFR, and adhesion molecule expression during rat intestinal ischemia/reperfusion injuryCurrent position: Manager, Early Drug Discovery ImmunologyAstellas Research Institute of America, Skokie, IL

7/1/00 - 6/30/01 Ann Kuhn, M.D.Project: A study of the effects of HB-EGF on apoptosis and oxygen free radical productionCurrent Position: Associate Professor of SurgeryKings Daughters Hospital, Norfolk, VA

7/01/01 - 6/30/03 Abigail Martin, M.D.

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Project: A study of the dose, route and timing of HB-EGF administration in intestinal ischemia/reperfusion injuryCurrent Position: Assistant Professor of Surgery, Duke University, Durham, NC

3/1/03 - 12/19/05 Jiexiong Feng, MD, Ph.D.Projects: 1) Study of the effect of HB-EGF in rodent models of experimental NEC2) Study of HB-EGF serum half-life, GI absorption and tissue distributionCurrent Position: Chief of Pediatric SurgeryWuhan Children’s Hospital, Wuhan, China

7/1/03 – 6/30/07 Osama El-Assal, M.D., Ph.D.Projects: 1) Study of the effect of HB-EGF in rodent models of intestinal I/R injury and HS/RCurrent Position: Associate Professor of PediatricsAkron Children’s Hospital, Akron, Ohio

7/01/04 - 6/30/06 Dorothy Rocourt, M.D.Projects: Study of the effect of HB-EGF on inflammatory cytokine expression in intestine exposed to I/R injury; study of the effect of HB-EGF on PMN-EC adhesion.Current Position: Assistant Professor of Surgery, Pennsylvania State University, Hershey, PA

7/1/06 - 6/30/07 Heather Paddock, M.D.Project: Study of the effect of HB-EGF on human intestine resected for NECCurrent position: Assistant Professor of Surgery, Loyola University, Chicago, IL

2/15/06 – 6/30/10 Andrei Radulescu, M.D., Ph.D.Projects: 1) Study of the effect of HB-EGF in rodent models of experimental NEC; 2) development of a mouse model of NEC; 3) Study of the effect of HB-EGF on anastomotic wound healing.Current Position: General Surgery Resident, Riverside Methodist Hospital, Columbus, OH

8/15/07 – 6/30/10 David Yu, M.D., M.A.Projects: 1) Study of the effect of HB-EGF on intestinal blood flow in experimental NECCurrent Position: Assistant Professor of Radiology, Ohio State University, Columbus, OH

11/1/07 – 5/30/11 Hong-yi Zhang, M.D.

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Project: Study of the effect of HB-EGF on hemorrhagic shock and resuscitationCurrent Position: General Surgery Resident, Tongji Medical Center, Wuhan, China

2/15/07 - present Yu Zhou, M.D., Ph.D.Projects: 1) Study of the effect of HB-EGF on human mesenteric arteriolar vasodilation ex vivo; 2) Study of the effect of HB-EGF on the enteric nervous system.

9/2/08 – 9/4/09 Claudio Lagoa, D.V.M., Ph.D.Project: 1) Study of the effect of HB-EGF on systemic inflammation

7/1/08 – 6/30/10 Iyore Otabor, M.D.Project: Study of the effect of HB-EGF on distant organ injury after intestinal ischemia/reperfusion injuryCurrent Position: General Surgery Resident, Ohio State University, Columbus, OH

2/8/08 – 11/1/11 Chun-Liang Chen, Ph.D.Projects: 1) Studies of the effects of HB-EGF on intestinal stem cellsCurrent Position: Assistant Professor

6/1/10 – 8/22/12 Jixin Yang, M.D.Project: Study of the effect of HB-EGF on CLP; Study of the effect of HB-EGF and MSC in protection of the intestines from NEC

7/12/10 – 6/30/13 Dan Watkins, M.D.Project: Study of the effect of HB-EGF and MSC on SMAO

6/1/11 – 8/22/12 Yanwei Su, M.D.Project: Study of the Effect of HB-EGF on Mediators of Restitution in Intestinal Epithelial Cells

7/1/11 – 6/30/13 Mika Matthews, M.D.Project: Project: Study of the effect of HB-EGF in radiation therapy-induced intestinal injuryCurrent Position: in training

12/12/11 – present Yanchun Liu, Ph.D.Project: Novel techniques for the production of tissue engineered intestine

7/1/12 – 6/30/13 Laura Boomer, M.D.

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Project: Novel techniques for the production of tissue engineered intestineCurrent Position: in training

7/1/12 – 9/30/14 Jia Wei, M.D.Project: Neural stem cell transplantation for the treatment of necrotizing enterocolitis

7/1/13 – 6/30/15 Terry Rager, M.D.Project: Production of human tissue engineered intestine

7/1/14 – 6/30/17 Jacob Olson, M.D.Project: The effects of probiotics and HB-EGF in the treatment of necrotizing enterocolitis

7/1/14 – 6/30/16 Barrett Cromeens, D.O., Ph.D.Project: Improved strategies for the production of human tissue engineered intestine

7/1/15-6/30/17 Chris McCulloh, M.D.Project: Stem cell-derived exosome therapy for the treatment of necrotizing enterocolitis

7/1/17-6/30/19 Courtney Pisano, D.O.Project: The effects of probiotics and HB-EGF in the treatment of necrotizing enterocolitis

7/1/17-6/30/19 Rita Shelby, M.D.Project: Stem cell-derived exosome therapy for the treatment of necrotizing enterocolitis

Ph.D. STUDENTS MENTORED

5/1/92 - 8/29/97 Karen Davis, Ph.D. Projects: Expression of rHB-EGF in a VV expression system; A study of the effects of HB-EGF glycosylationCurrent Position: North American Marketing ManagerAmersham Biosciences

Kevin PeineMolecular, Cellular and Developmental Biology Program Rotating graduate student, 2010Project: Determination of the EGF receptor subtypes necessary for HB-EGF mediated restitution.

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MASTERS DEGREE STUDENTS MENTORED

Curriculum VitaeGAIL ELLEN BESNER, M.D.Ph.D. STUDENTS – COMMITTEE MEMBER

10/1/99 - 9/30/01 DeAnna Ball, Ph.D.Project: CTGF Expression SystemsCurrent Position: Medical EditorColumbus, Ohio

8/1/09 – 6/1/14 Alissa CharrierProject: The Role of CTGF in Pancreatic FibrosisCurrent Position: post-doctoral fellow, The Cleveland Clinic

7/1/08 – 6/30/10 Iyore Otabor, M.D.Project: The ability of HB-EGF to protect the lungs from remote organ injury after intestinal ischemia/reperfusionCurrent Position: in training

7/1/11 – 6/30/13 Mika Matthews, M.D.Project: Study of the effect of HB-EGF in radiation therapy-induced intestinal injuryCurrent Position: in training

7/1/13 – 6/30/15 Terry Rager, M.D.Project: Production of human tissue engineered intestine

MEDICAL STUDENTS SUPERVISED (LABORATORY)

6/15/92 - 8/15/92 Michelle MackeyOSU College of MedicineRoessler Medical Student Research Scholarship Project: Creation of Anti-HB-EGF Neutralizing Antisera

6/10/96 - 12/1/96 Matthew Todd MillerOSU College of MedicineRoessler Medical Student Research Scholarship Project: Characterization of Tumors Produced by Heparin-Binding EGF-Like Growth Factor

6/15/99 - 8/15/99 Linda ChunOSU College of MedicineRoessler Medical Student Research Scholarship Project: Analysis of Human Milk and Amniotic Fluid Using an HB-EGF ELISA

6/15/01 - 8/15/01 Rahul Basho

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OSU College of MedicineRoessler Medical Student Research Scholarship Project: A Study of the Effect of HB-EGF on Chemotherapy-Induced Mucositis

8/15/06 - 9/30/06 Alejandro MarquezUniversity of Venezuela College of MedicineProject: A study of the ability of HB-EGF to protect the intestines from injury

8/11/07 - 10/11/07 Alejandro MarquezUniversity of Venezuela College of MedicineProject: A study of the ability of HB-EGF to protect the intestines from injury.

6/1/07 - 8/15/07 Nicholas ZorkoOSU College of MedicineNIH Roadmap Training in Clinical Research Program (RT-PCR) Project: The Role of HB-EGF in Protection against Necrotizing Enterocolitis in the Neonatal Mouse

8/16/07 - 11/30/07 Nicholas ZorkoOSU College of MedicineRoessler Medical Student Research Scholarship Project: The Role of HB-EGF in Protection against Necrotizing Enterocolitis in the Neonatal Mouse

6/1/07 - 8/15/07 Meghan RyanOSU College of MedicineRoessler Medical Student Research Scholarship Project: Mechanisms of HB-EGF Induced Angiogenesis during Healing from Intestinal Injury

6/1/08 - 8/15/08 Nathan OrvetsOSU College of MedicineRoessler Medical Student Research Scholarship Project: Heparin-Binding EGF-Like Growth Factor (HB-EGF) in the Prevention of NEC in Newborn Mice

8/16/08 - 10/30/08 Nathan OrvetsOSU College of MedicineRoessler Medical Student Research Scholarship Project: The Role of HB-EGF in Protection against Necrotizing Enterocolitis in the Neonatal Mouse

6/1/08 - 8/15/08 Sabrina Khalfoun

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OSU College of MedicineProject: Studies of HB-EGF and Protection of the Intestines from Injury

6/1/09 - 8/15/09 Jacob OlsonOSU College of MedicineRoessler Medical Student Research Scholarship Project: Studies of Anastomotic Wound Healing in HB-EGF TG and KO Mice

6/15/11 – 8/15/11 Bharath BhushanOSU College of MedicineRoessler Medical Student Research Scholarship Project: The Effect of HB-EGF and Mesenchymal Stem Cells on Protection of the Intestines from Necrotizing Enterocolitis

6/15/11 – 8/15/11 Avanti JakadtarOSU College of MedicineRoessler Medical Student Research Scholarship Project: The Ability of Heparin-Binding EGF-like Growth Factor (HB-EGF) to Promote Neural Stem Cell Colonization of Aganglionic Intestine

2/1/12-3/1/12 Nathan MahlerOSU College of MedicineProject: Production of tissue engineered small intestine

6/15/12-8/15/12 Sarah BrehmOSU College of MedicineRoessler Medical Student Research Scholarship Project: HB-EGF Knockout Mice are Less Responsive to Neural Stem Cell Therapy for Necrotizing Enterocolitis-induced Intestinal Dysmotility

6/15/13-8/15/13 Alice JiOSU College of MedicineRoessler Medical Student Research Scholarship Project: Production of Tissue Engineered Intestine

6/15/14-8/15/14 Kathleen PutmannOSU College of MedicineRoessler Medical Student Research Scholarship Project: Innervation and Functional Smooth Muscle Contraction of Tissue Engineered Intestine

5/26/15-7/31/15 Johnathan Stathopoulos

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MEDICAL STUDENTS MENTORED (CLINICAL)


University of South Carolina School of MedicineResearch Project: Improving the Production of Tissue Engineered Intestine

6/15/15-8/15/15 Kelli FisherOhio University Heritage College of Osteopathic MedicineResearch Project: Production of Tissue Engineered Intestine

6/15/16-8/15/16 Sarah GartnerOSU College of Medicine Medical Student Research Scholarship Project: Harvesting the Benefits of Biofilms: A Novel Probiotic/Prebiotic Delivery System for the Prevention of Necrotizing Enterocolitis

6/15/16-8/15/16 Deepa MandaNortheastern Ohio Medical University (NEOMED)Research Project: Integrin Depenence of NSC-Derved Exosome Targeting of Injured Intestinal Neurons

6/15/11 – 8/15/11 Pooja Shah (Ohio University College of Medicine)Project: Study of the Efficacy of Serial Peritoneal drainage in NEC

COLLEGE STUDENTS SUPERVISED (LABORATORY)

6/10/92 - 8/10/92 John Koff

7/1/97 - 8/30/97 April Edwards (The Ohio State University)

6/1/00 - 8/30/00 Brett Fleming (Dennison University)

6/1/00 - 8/30/00 Azim Haque (Case Western Reserve University)

6/25/10 – 8/30/10 Kyle Markmann (The Ohio State University)

6/25/10 – 8/30/10 Meghan O’Grady (Indiana Wesleyan University)

7/1/13 – 8/9/13 Alexandria Speakman (The Ohio State University)

7/1/14-8/30/14 Alexandria Speakman (The Ohio State University)

7/1/15-8/30/15 Natalie Huibregtse (The Ohio State Universty)

7/1/16 – 8/30/16 Shipra Khatri (Johns Hopkins University)

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7/1/16 – 8/30/16 Jen Vu (Ohio State University)

COLLEGE STUDENTS SUPERVISED (CLINICAL)

9/1/97 - 12/31/97 April Edwards (The Ohio State University)

6/1/10 – 7/31/10 Meghan O’Grady (Indiana Wesleyan University)

6/1/10 – 7/31/10 Kyle Markmann (The Ohio State University)

RESEARCH ASSISTANTS / ASSOCIATES SUPERVISED (LABORATORY)

8/15/91 - 7/1/98 Missy Crissman-Combs

12/8/98 - 10/29/99 Cynthia Moder

7/12/99 - 6/30/00 Vicki Trapp

10/22/99 - 6/30/00 Michelle Furchner

7/1/00 - 5/30/01 Sandy Glenn

1/1/02 - 11/24/02 Karen Neal

4/1/03 - 6/30/07 Dana Wu

8/6/07 – 8/31/09 Yan Chen

5/4/09 – 7/15/12 Amanda Darbyshire

7/16/12 – 10/1/14 Palak Painter

7/14/14 – 10/15/14 Monalee Saha

2/6/15 – pres Yijie Wang

HIGH SCHOOL STUDENTS SUPERVISED (LABORATORY)

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7/19/93 - 8/16/94 Paula Catanio

4/22/96 - 5/24/96 Kim Cooper

8/2/10 – 9/1/10 Esther Jung (Columbus Academy)

6/15/11 – 8/15/11 Esther Jung (Columbus Academy)

7/1/15 – 8/1/15 Max Michalsky (Dublin Scioto High School)

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PUBLICATIONS

Journal Articles

* indicates peer-review

*1. Utermohlen V, Besner G, Ginsparg-Berkowitz M: The Effect of Fatty Acid Addition In Vitro on Direct Migration Inhibition with Paramxyoviral Antigens. Clin Immunol Immunopathol 16(3):324-335, July 1980. PMCID: PMC6249530.

*2. Utermohlen V, Coniglio J, Mayo D, Sierra J, Smith R, Besner G, Hutchins S, Spitzer K, Tomasso J, Boyar A: Unsaturated Fatty Acids and Human Mononuclear Cell Function. Prog Lipid Res 20:739-741, 1981. PMCID: PMC7342126.

3. Besner G and Tilney N: Peripheral Arterial Embolus. In Cameron JL (ed): Current Surgical Therapy. New York and Baltimore , BC Dexter and CV Mosby, 1986, p 381-384.

*4. Besner G, Higashiyama S, and Klagsbrun M: Isolation and Characterization of a Macrophage-Derived Heparin-Binding Growth Factor. Cell Regul (now Mol Biol Cell) 1(11):811-819, Oct1990. PMCID: PMC2088527.

*5. Stannard V, Fowler C, Robinson L, Besner G, Glick P, Allen J, Jewett T, Cooney D: Familial Hirschsprung's Disease: Report of Autosomal Dominant and Probable Recessive X-Linked Kindreds. J Pediatr Surg 26(5): 591-594, May 1991. PMCID: PMC2061816.

*6. Besner G, Klagsbrun M: Macrophages Secrete a Heparin-Binding Inhibitor of Endothelial Cell Growth. Microvascul Res 42(2):187-197, Sept1991. PMCID: PMC1719354.

*7. Besner G, Whelton D, Crissman-Combs M, Steffen C, Kim G, Brigstock D: Interaction of Heparin-Binding EGF-Like Growth Factor (HB-EGF) with the Epidermal Growth Factor Receptor: Modulation by Heparin, Heparinase or Synthetic Heparin-Binding HB-EGF Fragments. Growth Factors 7(4):289-296, 1992. PMCID: PMC1306684.

*8. Besner G, Glick P, Karp M, Wang W, Lobe T, White C, Cooney D: Recombinant Human Granulocyte Colony-Stimulating Factor Promotes Wound Healing In a Patient with Congenital Neutropenia. J Pediatr Surg 27(3):288-291, March 1992. PMCID: PMC1380074.

*9. Higashiyama S, Lau K, Abraham J, Besner G, Klagsbrun M: Structure of Heparin-Binding EGF-Like Growth Factor: Multiple Forms, Primary Structure and Glycosylation of the Mature Protein. J Biol Chem 267(9):6205-6212, Mar1992. PMCID: PMC1556128 .

*10. Glick P, Leach C, Besner G, Egan E, Morin F, et al: Pathophysiology of Congenital Diaphragmatic Hernia III: Exogenous Surfactant Therapy for the High-Risk Neonate with CDH. J Pediatr Surg 27(7):866-869, July1992. PMCID: PMC1640336.

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*11. Besner G, Fisher J, Nazzadri F, Karp M, Jewett T, Cooney D: Teratoma in a Thyroglossal Duct Cyst: A Rare Occurrence. Pediatr Surg Int 8:66-70, 1993.

*12. Teitelbaum D, Teich S, Cassidy S, Karp M, Cooney D, Besner G: Highly Vascularized Sacrococcygeal Teratoma: Description of this Atypical Variant and its Operative Management. J Ped Surg 29(1):98-101, Jan 1994. PMCID: PMC8120774.

*13. McCarthy D, Qualman S, Besner G: Absent Intestinal Musculature: Anatomic Evidence of an Embryologic Origin of the Lesion. J Ped Surg 29(11):1476-1478, Nov 1994. PMCID: PMC7844725.

*14. Mutabagani K, Beaver B, Cooney D, Besner G: Penetrating Neck Trauma in Children: A Reappraisal. J Pediatr Surg 30(2): 341-344, Feb 1995. PMCID: PMC7738762.

*15. Kim G, Besner G, Steffen C, McCarthy D, Downing M, Luquette M, Abad M, Brigstock D: Purification of Heparin-Binding Epidermal Growth Factor-Like Growth Factor From Pig Uterine Luminal Flushings, and its Production by Endometrial Tissues. Biol Reprod 52(3):561-571, Mar 1995. PMCID: PMC7538797.

*16. Martinez DA, O'Dorisio S, O'Dorisio TM, Qualman SJ, Caniano DA, Teich S, Besner GE, King, DR: Intraoperative Detection and Resection of Occult Neuroblastoma: a Technique Exploiting Somatostatin Receptor Expression. J Pediatr Surg 30(11):1580-1589, Nov 1995. PMCID: PMC8583329.

*17. Vegunta R, Cooney D, Besner G, Brigstock D: Unique Protein Expression by the TBJ Clonal Derivative of C1300 Murine Neuroblastoma. J Pediatr Surg 30(12):1668-1672, Dec 1995. PMCID: PMC8749920.

*18. McCarthy D, Downing M, Brigstock D, Luquette M, Brown K, Abad M, Besner G: Production of Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) at Sites of Thermal Injury in Pediatric Patients. J Investig Dermatol 106(1):49-56, Jan 1996. PMCID: PMC8592081.

*19. Besner G, Qualman S, Gosche J: Identification of a Duplicated Undescended Testicle (Polyorchia) - An Unexpected Benefit of Laparoscopic Localization. J Laparoendoscopic Surg 6(Suppl 1):107-114, Mar 1996. PMCID: PMC8832940.

*20. Harding P, Brigstock D, Shen L, Crissman-Combs M, Besner G: Characterization of the Gene encoding Murine Heparin-Binding Epidermal Growth Factor-Like Growth Factor. Gene 169(2):291-292, Mar 1996. PMCID: PMC8647467 .

*21. McCarthy D, Besner G, Gosche J, Qualman S, Chan D, Olson T: Retroperitoneal Yolk Sac Tumor with Spinal Cord Compression and Intracardiac Extension. Int J Pediatr Heme/Oncol 3:157-161, 1996.

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*22. Davis K, Brigstock D, Johnson P, Crissman-Combs M, McCarthy D, Downing M, Besner G: Production of Glycosylated Heparin-Binding EGF-Like Growth Factor in HeLa Cells Using Vaccinia Virus. Protein Expression and Purification 8(1):57-67, Aug 1996. PMCID: PMC8812835.

*23. Bensard D, Beaver B, Besner G, Cooney D: Small Bowel Injury in Children Sustaining Blunt Abdominal Injury: Is Delayed Diagnosis Important? J Trauma 41(3):476-483, Sept 1996. PMCID: PMC8810966.

24. Mutabagani K, Beaver B, Cooney D, Besner G: Penetrating Neck Trauma in Children: A

Reappraisal. In BR King (ed): Year Book of Emergency Medicine, Mosby-Year Book, Inc, Chicago, 1996, 253-255.

25. Besner G: Taking Burn Care into the 21st Century. Pediatric Directions 7:10-12, 1997.

*26. Downing M, Hamoudi A, Besner G: Brain Heterotopia: Choristoma of the Back. Pediatr Surg Int 12(2-3):183-185, Feb 1997. PMCID: PMC9156853.

*27. Zubair M and Besner G: Pediatric Electrical Burns: Management Strategies. Burns 23(5), 413-420, Aug 1997. PMCID: PMC9426911.

*28. Singh S, Besner G, Schauer G: Pulmonary Endodermal Tumor Resembling Fetal Lung -Report of a Case in a 14-Year Old Girl. Pediatr. Pathol. and Lab. Medicine 17(6):871-878, Nov-Dec 1997. PMCID: PMC9353835.

*29. Downing M, Brigstock D, Luquette M, Crissman-Combs M, Besner G: Immunohistochemical Localization of Heparin-Binding Epidermal Growth Factor-like Growth Factor in Normal Skin and Skin Cancers. Histochem J 29(10):735-744, Oct 1997. PMCID: PMC9429077.

*30. Davis-Fleischer K, Besner G: Structure and Function of Heparin-Binding EGF-Like Growth Factor (HB-EGF). Frontiers in Bioscience 3, 288-299, Mar 1998. PMCID: PMC9473209.

*31. Cribbs R, Luquette M, Besner G: Acceleration of Partial-Thickness Burn Wound Healing with Topical Application of Heparin-Binding EGF-Like Growth Factor (HB-EGF). J Burn Care and Rehab 19(2):95-101, April 1998. PMCID: PMC9556308.

*32. Bethel C, Luquette M, Besner G: Cystic Degeneration of Heterotopic Pancreas. Pediatr Surg Int 13(5-6):428-430, July1998. PMCID: PMC9639636.

*33. Pillai S, Turman M, Besner G: Heparin-Binding EGF-Like Growth Factor is Cytoprotective for Intestinal Epithelial Cells Exposed to Hypoxia. J Pediatr Surg 33(7):973-979, July 1998. PMCID: PMC9694080.

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*34. Bethel C, Mutabagani K, Hammond S, Besner G, Caniano D, Cooney D: Nonteratomatous Germ Cell Tumors in Children. J Pediatr Surg 33(7):1122-1127, July 1998. PMCID:PMC9694107.

*35. Pillai S, Luquette M, Nowicki P, Besner G: Segmental Intestinal Ischemia: An Improved Method of Producing Small Bowel Injury. J Investig Surg 11(2):123-128, Mar-Apr1998. PMCID: PMC9700620.

*36. Besner G, Klamar J: IntegraTM Artificial Skin as a Useful Adjunct in the Treatment of Purpura Fulminans. J Burn Care and Rehab 19(4):324-329, Jul-Aug 1998. PMCID: PMC9710731.

37. Pillai, S, Besner G: Pediatric Testicular Problems. In P Glick, M Irish and M Caty (eds): Pediatric Clinics of North America, WB Saunders, Co., Philadelphia, volume 45(4), 813-830, Aug 1998. PMCID: PMC9728188.

*38. Cribbs R, Luquette M, Besner G: A Standardized Model of Partial Thickness Scald Burns in Mice. J Surg Research 80(1), 69-74, Nov 1998. PMCID: PMC9790817.

*39. Mutabagani K, Zumberge N, Coley B, Martin L, Shields W, McCarthy D, Besner G, Caniano D Cooney D: Preliminary Evidence with Focused Abdominal Sonography for Trauma (FAST) in Children: Is it Useful? J Pediatr Surg 34(1), 48-54, Jan 1999. PMCID: PMC10022142.

*40. Mutabagani K, Menke J, McCoy K, Besner G: Bronchopexy for Congenital Bronchomalacia in the Newborn. J Pediatr Surg 34(8), 1300-1303, Aug 1999. PMCID: PMC10466621.

*41. Harding P, Davis-Fleischer K, Crissman-Combs M, Miller M, Brigstock D, Besner G: Induction of Anchorage Independent Growth by Heparin-Binding EGF-Like Growth Factor (HB-EGF). Growth Factors 17(1):49-61, 1999. PMCID: PMC10495962.

*42. McCarthy D, Qualman S, Wiet G, Besner G: Herpetic Tracheitis and Brachial Plexus Neuropathy in a Burned Child. J Burn Care and Rehab 20(5):377-381, Sept-Oct 1999. PMCID: PMC10501325.

*43. Pillai S, Hinman,C, Luquette M, Nowicki,P, Besner G: Heparin-Binding Epidermal Growth Factor-Like Growth Factor Protects Rat Intestine From Ischemia/Reperfusion Injury. J Surg Research 87(2), 225-231, Dec 1999. PMCID: PMC10600353.

44. Zubair M, Besner G: Pediatric Electrical Burns: Management Strategies. In E Deitch (ed): Year Book of Surgery, Mosby-Year Book, Inc, Chicago, 1999.

45. Besner G: Testicular Problems and Varicoceles. In P Glick, M Caty, R Pearl, and M Irish (eds): Pediatric Surgical Secrets, Hanley and Belfus, Inc., Philadelphia, 209-213, 2000.

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46. Besner G: Burns. In P Glick, M Caty, R Pearl, and M Irish (eds): Pediatric Surgical Secrets, Hanley and Belfus, Inc., Philadelphia, 246-252, 2000.

*47. Coley BD, Mutabagani KH, Martin LC, Zumberge N, Cooney DR, Caniano DA, Besner GE, Groner JI, Shiels WE: Focused Abdominal Sonography for Trauma (FAST) in Children with Blunt Abdominal Trauma. J Trauma, 48(5), 902-906, May 2000. PMCID: PMC10823534.

*48. Pillai SB, Bethel CA, Besner GE, Caniano DA, Cooney DR: Fall Injuries in the Pediatric Population: Safer and Most Cost Effective Management. J Trauma, 48(6), 1048-1051, June 2000. PMCID: PMC10866249.

*49. Vegunta RK, Morotti RA, Shiels WE, Rauck A, Besner GE: Collision Tumors in Children: A Review of the Literature and Presentation of a Rare Case of Mesoblastic Nephroma and Neuroblastoma in an Infant. J Pediatr Surg, 35(9), 1359-1361, Sept 2000. PMCID: PMC10999699.

*50. Michalsky MP, Kuhn A, Mehta V, Besner G: Heparin-Binding EGF-Like Growth Factor Decreases Apoptosis in Intestinal Epithelial Cells in Vitro. J Pediatr Surg, 36(8):1130-1135, Aug 2001. PMCID: PMC11479841.

*51. Xia G, Lara-Marquez, M, Luquette M, Haque A, Besner G: Heparin-Binding EGF-Like Growth Factor Decreases Inducible Nitric Oxide Synthase and Nitric Oxide Production after Intestinal Ischemia/Reperfusion Injury. Antiox Redox Signal 3(5), 919-930, Oct 2001. PMCID: PMC11761337.

*52. Davis-Fleischer K, Brigstock D, Besner G: Site-directed Mutagenesis of Heparin-Binding EGF-Like Growth Factor (HB-EGF): Analysis of O-Glycosylation Sites and Properties. Growth Factors 19(2), 127-143, 2001. PMCID: PMC11769972.

*53. Michalsky M, Lara-Marquez M, Chun L, Besner G: Heparin-Binding EGF-Like Growth Factor is Present in Human Amniotic Fluid and Breast Milk. J Pediatr. Surg. 37(1), 1-6, Jan 2002. PMCID: PMC11781977.

*54. Cribbs R, Harding P, Luquette M, Besner G: Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing. J Burn Care and Rehab 23(2):116-125, Mar-Apr 2002. PMCID: PMC11882801 .

*55. Lara-Marquez M, Mehta V, Michalsky M, Fleming J, Besner G: Heparin-Binding EGF-Like Growth Factor Down regulates ProInflammatory Cytokine-Induced Nitric Oxide and inducible Nitric Oxide Synthase Production in Intestinal Epithelial Cells. Nitric Oxide 6(2), 142-152, Mar 2002. PMCID: PMC11890738.

*56. Michalsky M, Besner G: Alimentary Tract Duplications. In Scoll Plantz (ed): Pediatrics: E-Medicine, 2002. eMedicine from WebMD. Updated March 09, 2010. Available at: http://emedicine.medscape.com/article/933427-overview.

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*57. O’Connor A, Besner G: Burns: Surgical Perspective. In Scoll Plantz (ed): Pediatrics: E-Medicine, 2002.

*58. Xia G, Martin A, Michalsky M, Besner G: Heparin-Binding EGF-Like Growth Factor Preserves Crypt Cell Proliferation and Decreases Bacterial Translocation after Intestinal Ischemia/Reperfusion Injury. J Pediatr. Surg. 37(7):1081-1087, July 2002. PMCID: PMC12077776.

59. Kuhn A, Besner G: Breast Disorders. In Peter Mattei (ed): Surgical Directives: Pediatric Surgery, Lippincott, Williams & Wilkins, Inc., 701-705, 2002.

*60. Kuhn A, Xia G, Mehta V, Glenn S, Michalsky M, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Decreases Oxygen Free Radical Production In Vitro and In Vivo. Antioxid Redox Signal 4(4):639-646, Aug 2002. PMCID: PMC12230876.

*61. Xia G, Martin A, Besner G: Heparin-Binding EGF-Like Growth Factor Downregulates Expression of Adhesion Molecules and Infiltration of Inflammatory Cells After Intestinal Ischemia/Reperfusion Injury. J Pediatr Surg. 38(3):434-439, Mar 2003. PMCID: PMC12632363.

*62. Xia G, Rachfal A, Martin A, Besner G: Upregulation of Endogenous Heparin-Binding EGF-Like Growth Factor (HB-EGF) Expression after Intestinal Ischemia/Reperfusion Injury. J Investig Surgery 16(2):1-7, Mar-Apr 2003. PMCID: PMC12746188.

63. Besner G: Burn Care at Children’s Hospital. Critical Measures, Children’s Hospital, 3:4, 2003.

*64. Mehta V and Besner G: Inhibition of Nuclear Factor Kappa- Activation and its Target Genes by Heparin-binding Epidermal Growth Factor-like Growth Factor. J Immunol 171(11):6014-6022, Dec 2003. PMCID: PMC14634113.

65. Besner G: Burn Care. Critical Measures, Children’s Hospital, November, 2003.

*66. El-Assal O and Besner G: Heparin-binding Epidermal Growth Factor-like Growth Factor and Intestinal Ischemia-Reperfusion Injury. Seminars in Pediatric Surgery 13(1):2-10, Feb 2004. PMCID: PMC14765365.

*67. Corpron C, Martin A, Roberts G, Besner G: The Pediatric Burn Unit: A Profit Center. J Pediatr Surg 39(6):961-963, June 2004. PMCID: PMC15185234.

*68. Besner G, Bates G, Boesel C, Singh V, Welty S, Corpron C: Total Absence of the Small Bowel in a Premature Neonate. Pediatr Surg Int 21(5):396-399, May 2005. PMCID: PMC15809847.

*69. Nowicki PT, Besner G, Hammond S and Caniano D. Endothelin-1 in Human Intestine Resected for Necrotizing Enterocolitis. J Pediatr 146(6):805-810, June 2005. PMCID: PMC15973323.

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*70. Provenzano A, Besner G, James P, Harding P: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Overexpression in Transgenic Mice Downregulates Insulin-like Growth Factor Binding Protein (IGFBP)-3 and -4 mRNA. Growth Factors 23(1):19-31, Mar 2005. PMCID: PMC16019424.

*71. Mehta V and Besner G: Heparin-binding Epidermal Growth Factor-like Growth Factor Inhibits Cytokine-Induced NF-kappa B Activation and Nitric Oxide Production via Activation of the phosphatidylinositol 3-Kinase Pathway. J Immunol 175(3):1911-1918, Aug 2005. PMCID: PMC16034135.

*72. El-Assal O and Besner G: HB-EGF Enhances Restitution After Intestinal Ischemia/Reperfusion via PI3-k/Akt and MEK/ERK1/2 Activation. Gastroenterology 129(2):609-625, Aug 2005. PMCID: PMC16083716.

*73. Feng J, El-Assal O, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF)

and Necrotizing Enterocolitis. Seminars in Pediatric Surgery 14(3):167-174, Aug 2005. PMCID: PMC16084404.

*74. Martin A and Besner G: Timing, Route and Dose of Administration of Heparin-binding Epidermal Growth Factor-like Growth Factor in Protection against Intestinal Ischemia-Reperfusion Injury. J Pediatr Surg 40(11):1741-1747, Nov 2005. PMCID: PMC16291163.

*75. Feng J, Mehta V, El-Assal O, Wu D, Besner G: Tissue Distribution and Plasma

Clearance of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Adult and Newborn Rats. Peptides 27(6):1589-1596, June 2006. PMCID: PMC16364500.

*76. Feng J, El-Assal O, Besner G: Heparin-binding Epidermal Growth Factor-like Growth Factor Decreases the Incidence of Necrotizing Enterocolitis in Neonatal Rats. J Pediatr Surg 41(1):144-149, Jan 2006. PMCID: PMC16410124 .

*77. Nowicki P, Reber K, Giannone P, Nankervis C, Hammond S, Besner G, Caniano D:

Intestinal O2 Consumption in Necrotizing Enterocolitis: Role of Nitric Oxide. Pediatric Research 59(4 part 1):500-505, Apr 2006. PMCID: PMC16549519.

*78. Feng J, El-Assal O, Besner G: Heparin-binding Epidermal Growth Factor-like Growth Factor Reduces Intestinal Apoptosis in Neonatal Rats with Necrotizing Enterocolitis. J Pediatr Surg 41(4):742-747, Apr 2006. PMCID: PMC16567187.

*79. Rocourt DV, Shiels WE, Hammond S, Besner G: Contemporary Management of Benign Hepatic Adenoma using Percutaneous Radiofrequency Ablation (RFA). J Pediatr Surg 41(6):1149-1152, June 2006. PMCID: PMC16769351.

*80. Paddock H, Nguyen L, Kay S, Besner G: Choledochal Cyst: Surgical Perspective. In Scoll Plantz (ed): Pediatrics: E-Medicine, 2006.

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*81. Nowicki PT, Caniano DA, Hammond S, Giannone PJ, Besner GE, Reber KM, Nankervis CA: Endothelial Nitric Oxide Synthase in Human Intestine Resected for Necrotizing Enterocolitis. J Pediatrics 150(1): 40-45, Jan 2007. PMCID: PMC17188611.

*82. Paddock H, Fabia R, Giles S, Hayes J, Adams D, Besner G: A Silver Impregnated Antimicrobial Dressing Reduces Hospital Cost in Pediatric Burn Patients. J Pediatr Surg 42(1):211-213, Jan 2007. PMCID: PMC17208568.

*83. Feng J and Besner G: Heparin-binding Epidermal Growth Factor-like Growth Factor Promotes Enterocyte Migration and Proliferation in Neonatal Rats with Necrotizing Enterocolitis. J Pediatr Surg 42(1):214-220, Jan 2007. PMCID: PMC17208569.

*84. Rocourt D, Mehta V, Besner G: Heparin-Binding EGF-Like Growth Factor Decreases Inflammatory Cytokine Expression after Intestinal Ischemia/Reperfusion Injury. J Surg Res 139(2):269-273, May 2007 (EPub 2007 Feb 7). PMCID: PMC17291530.

*85. Lambert DK, Christensen RD, Henry E, Besner GE, Baer VL, Wiedmeier SE, Stoddard RA, Miner C, Burnett J: Necrotizing Enterocolitis in Term Neonates: Data From a Multihospital Healthcare System. J Perinatology 27(7): 437-443, July 2007 (EPub 2007 Mar 29). PMCID: PMC17392837.

*86. Paddock H, Fabia R, Giles S, Hayes J, Lowell W, Besner G: A Silver Impregnated Antimicrobial Dressing Reduces Hospital Length of Stay for Pediatric Patients with Burns. J Burn Care Research 28(3):409-11, May-June 2007. PMCID: PMC17458510.

*87. Rocourt D, Mehta V, Besner G: Heparin-Binding EGF-like Growth Factor Decreases Neutrophil-Endothelial Cell Interactions. J Surg Res 141(2):262-266, Aug 2007 (EPub 2007 June 14). PMCID: PMC17574583.

*88. El-Assal O, Radulescu A, Besner G: Heparin-binding EGF-like Growth Factor Preserves Mesenteric Microcirculatory Blood Flow and Protects against Intestinal Injury in Rats Subjected to Hemorrhagic Shock and Resuscitation. Surgery 142(2):234-242, Aug 2007. PMCID: PMC17689691.

*89. Mehta V, Besner G: HB-EGF Promotes Angiogenesis in Endothelial Cells via PI3-kinase and MAPK Signaling Pathways. Growth Factors 25(4):253-263, Aug 2007. PMCID: PMC18092233.

*90. Shiels W, Kenney B, Caniano D, Besner G: Definitive Percutaneous Treatment of Lymphatic Malformations of the Trunk and Extremities. J Pediatr Surg 43(1):136-139, Jan 2008. PMCID: PMC18206471 .

*91. El-Assal O, Paddock H, Marquez A, Besner G: Heparin-binding Epidermal Growth Factor-like Growth Factor Gene Disruption is Associated with Delayed Intestinal Restitution, Impaired Angiogenesis, and Poor Survival after Intestinal Ischemia in Mice. J Pediatr Surg 43(6):1182-1190, June 2008. PMCID: PMC18558204.

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*92. Arora A, Caniano D, Hammond S, Besner G: Inversion Appendectomy as a Lead Point for Intussusception. Pediatr Surg Int 24(11):1261-1264, Nov 2008. PMCID: PMC18810462.

*93. Mehta V, Zhou Y, Radulescu A, Besner G: HB-EGF Stimulates eNOS Expression and Nitric Oxide Production and Promotes eNOS Dependent Angiogenesis. Growth Factors 26(6):301-315, Dec 2008. PMCID: PMC18925469.

*94. Radulescu A, Zorko N, Yu X, Besner G: Preclinical Neonatal Rat Studies of Heparin-binding EGF-like Growth Factor in Protection of the Intestines from Necrotizing Enterocolitis. Pediatr Res 65(4):437-442, April 2009. PMCID: PMC19127201.

*95. Otabor I, Erdman S, Abdessalam S, Besner G: Gastric Outlet Obstruction due to Adenocarcinoma in a Patient with Ataxia-Telangiectasia Syndrome: Case Report and Review of the Literature. World Journal of Surgical Oncology 7:29, March 2009. PMCID: PMC19284625.

*96. Otabor I, Balant J, Besner G: Myectomy-Myotomy for Long Segment Hirschprung’s Disease in a Patient with Haddad Syndrome. J Pediatr Surg 44(3):620-622, March 2009. PMCID: PMC19302869.

*97. Otabor I, Besner G: Burns: Surgical Perspective. In Scoll Plantz (ed): Pediatrics: E-Medicine, 2009.

*98. Zhou Y, Brigstock, D, Besner G: Heparin-binding EGF-like Growth Factor is a Potent Dilator of Terminal Mesenteric Arterioles. Microvascular Research 78(1):78-85, June 2009. PMCID: PMC19389413.

*99. Yu X, Radulescu A, Zorko N, Besner G: Heparin-Binding EGF-like Growth Factor Increases Intestinal Microvascular Blood Flow in Necrotizing Enterocolitis. Gastroenterology 137(1):221-230, July 2009. PMCID: PMC19361505 .Special Honor: Journal Cover Figure Special Honor: Video Abstract hosted by the American Gastroenterology association on YouTube (http://www.youtube.com/watch?v=84zsbXDEgL8)

*100. Christensen RD, Wiedmeier SE, Baer VL, Henry E, Gerday E, Lambert DK, Burnett J, Besner GE: Antecedents of Bell Stage III Necrotizing Enterocolitis. J Perinatology. 30(1):54-57, Jan 2010. PMCID: PMC19609307.

*101. Zhang, H-Y, Radulescu A, Besner G: Heparin-binding Epidermal Growth Factor-like Growth Factor is Essential for Preservation of Gut Barrier Function after Hemorrhagic Shock and Resuscitation in Mice. Surgery 146(2): 334-339, Aug 2009. PMCID: PMC19628093.

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*102. Chen C-L, Mehta V, Wu D, Otabor I, El-Assal O, Feng J, Radulescu A, Zhang H-Y, Chen Y, Besner G: Intestinal Phenotype in Mice Overexpressing a Heparin-Binding EGF-like Growth Factor Transgene in Enterocytes. Growth Factors 28(2):82-97, April 2010. PMCID: PMC19939201.

*103. Radulescu A, Yu X, Orvets N, Chen Y, Zhang H-Y, Besner G: Deletion of the Heparin-binding Epidermal Growth Factor-like Growth Factor Gene Increases Susceptibility to Necrotizing Enterocolitis. J Pediatr Surg 45(4):729-734, April 2010. PMCID: PMC20385279.

*104. Askegard-Giesmann J, Besner G, Fabia R, Caniano D, Preston T, Kenney B: Extracorporeal Membrane Oxygenation (ECMO) as a Life-Saving Modality in the Treatment of Pediatric Patients with Burns and Respiratory Failure. J Pediatr Surg 45(6):1330-1335, June 2010. PMCID: PMC20620340.

*105. James I, Chen C-L, Huang G, Zhang H-Y, Velten M, Besner G: Heparin-Binding EGF-Like Growth Factor Protects the Lungs from Remote Injury After Intestinal Ischemia/Reperfusion. J Surg Res 163(1):86-95, Sept 2010 (EPub 2010 April 24). PMCID: PMC20599214.

*106. Radulescu A, Zhang H-Y, Yu X, Olson J, Darbyshire A, Chen Y, Besner G: Heparin-Binding EGF-Like Overexpression in Transgenic Mice Increases Resistance to Necrotizing Enterocolitis. J Pediatr Surg 45(10):1933-1939, Oct 2010. PMCID: PMC20920709.

*107. Zhang H-Y, Radulescu A, Chen Y, Besner G: HB-EGF Improves Intestinal Microcirculation after Hemorrhagic Shock. J Surg Res 171(1):218-225, Nov 2010 (EPub 2010 Feb 11). PMCID: PMC20421109.

*108. Christensen R, Gordon P, Besner G: Can We Cut the Incidence of Necrotizing Enterocolitis in Half – Today? Fetal and Pediatric Pathology 29(4):1-14, 2010. PMCID: PMC20594142.

*109. Besner G: Pediatric Burn Management. Fundamentals of Pediatric Surgery, Chapter 20. Peter Mattei (ed). 2010.

*110. Zhou Y and Besner G: Heparin-Binding EGF-Like Growth Factor is a Neurotrophic Factor for PC12 Cells. Neurosignals 18(3):141-151, 2010 (EPub 2010 Sept 16). PMCID: PMC20847549.

*111. Radulescu A, Zhang H-Y, Chen C-L, Chen Y, Zhou Y, Yu X, Otabor I, Olson J, Besner G: Heparin-Binding EGF-Like Growth Factor Promotes Intestinal Anastomotic Healing. J Surg Res 171(2):540-550, Dec 2011 (EPub 2010 Sept 8). PMCID: PMC20850767.

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*112. Zhang H-Y, Radulescu R, Chen C-L, Olson J, Darbyshire A, Besner G: Mice Overexpressing the Gene for Heparin-Binding EGF-Like Growth Factor (HB-EGF) Have Increased Resistance to Hemorrhagic Shock and Resuscitation. Surgery 149(2):276-283, Feb 2011 (EPub 2010 Oct 20). PMCID: PMC20965535.

*113. Giannone P, Richtor J, Alcamo A, Schanbacher B, Mofleh M, Luce W, Han B, Nanervis C, Besner G, Bauer J: Poly(ADP-Ribose) Polymerase-1: A Novel Therapeutic Target in Necrotizing Enterocolitis. Pediatric Research 70(1):67-71, July 2011. PMCID:PMC21399558.

*114. Rocourt D, Hall M, Kenney B, Fabia R, Groner J, Besner G: Respiratory Failure after Pediatric Scald Injury. J Ped Surg 46(9): 1753-1758, Sept 2011. PMCID:PMC21929985.

*115. Otabor I, Druhan S, Caniano D, Besner G: The Presence but not the Location of an Appendicalith can Affect the Success of Interval Appendectomy for Ruptured Appendicitis in Children. Surg Sci 2:39-44, 2011.

*116. Yu X, Radulescu A, Chen C-L, James IO, Besner G: Heparin-Binding EGF-like Growth Factor Protects Pericytes from Injury. J Surg Research 172(1):166-176, Jan 2012. (EPub 2010 Sept 17). PMCID: PMC20863525.

*117. Lambert DK, Christensen RD, Baer VL, Henry E, Gordon PV, Besner GE, Wilkins J, Wiedmeier SE, Gerday E: Fulminant fatal necrotizing enterocolitis in a multihospital healthcare system. J Perinatology 32(3):194-198, March 2012 (EPub 2011 May 12). PMCID:PMC21566569.

*118. Chen C-L, Yu Xiaoyi Y, Otabor I, Zhang H-Y, Yang J, Radulescu A Zhou Y, Besner G: HB-EGF Protects Intestinal Stem Cells from Injury in a Rat Model of Necrotizing Enterocolitis. Laboratory Investigation 92(3):331-44, March 2012. PMCID:PMC22157721.

*119. Zhang H-Y, James I, Chen C-L, Besner G: Heparin-Binding EGF-like Growth Factor (HB-EGF) Preserves Gut Barrier Function by Blocking Neutrophil-Endothelial Cell Adhesion after Hemorrhagic Shock and Resuscitation in Mice. Surgery 151(4):594-605, April 2012. PMCID:PMC22153812.

*120. Huang G, Besner G, Brigstock D: Heparin-Binding Epidermal Growth Factor-like Growth Factor Suppresses Experimental Liver Fibrosis in Mice. Lab Investigation 92(5):703-712, May 2012 (Epub 2012 Feb 13). PMCID:PMC22330337.

*121. Watkins D, Zhou Y, Chen C-L, Darbyshire M, Besner G: Heparin-binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) Protects Mesenchymal Stem Cells. J Surg Res 177(2):359-364, October 2012 (EPub 2012 May 23). PMCID:PMC22658491 .

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*122. Yang J, Chen C-L, Watkins D, Zhang H-Y, Besner G: Heparin-binding Epidermal Growth Factor-Like Growth Factor and Mesenchymal Stem Cells Act Synergistically to Prevent Experimental Necrotizing Enterocolitis. Journal of the American College of Surgeons 215(4):534-545, Oct. 2012 (EPub 2012 July 21). PMCID:PMC22819639.

*123. Zhou Y, Chen C-L, Besner G: Heparin-Binding Epidermal Growth Factor-Like Growth Factor Promotes Murine Enteric Nervous System Development and Enteric Neural Crest Cell Migration. J Pediatr Surg 47(10):1865-1873, Oct. 2012. PMCID:PMC23084199.

*124. Yang J, Watkins D, Chen C-L, Zhang H-Y, Zhou Y, Velten M, Besner G: A Technique for Systemic Mesenchymal Stem Cell Transplantation in Newborn Rat Pups. J Investig Surg 25(6):405-414, Dec 2012. PMCID:PMC23215798.Special Honor: Journal Cover Figure

*125. Yang J, Radulescu A, Chen C-L, Zhang H-Y, James I, Chen Y, Besner G: HB-EGF Improves Intestinal Barrier Function and Reduces Mortality in a Murine Model of Peritonitis. Surgery 153(1):359-364, Jan 2013 (Epub 2012 June 15). PMCID:PMC22703966.

*126. Su Y, Yang J, Besner G: HB-EGF Promotes Intestinal Restitution by Affecting Integrin-Extracellular Matrix Interactions and Intercellular Adhesions. Growth Factors 31:39-55, Feb 2013 (Epub 2013 Jan 10). PMCID:PMC23305395.

*127. Watkins D and Besner G: The Role of the Intestinal Microcirculation in Necrotizing Enterocolitis. Seminars in Pediatric Surgery 22:83-87, May 2013. PMCID:PMC23611611.

*128. Matthews M, Adler B, Arnold M, Kumar S, Carvalho R, Besner G: Diffuse Intestinal Ganglionuromatosis in a Child J Pediatr Surg 48:1129-1133, May 2013. PMCID:PMC23701793.

*129. Odar C, Kirschman K, Pelley T, Butz C, Besner G, Fabia R: Prevalence and Correlates of Posttraumatic Stress in Parents of Young Children Postburn. J Burn Care Res 34:299-306, May-June 2013. PMCID:PMC23128125.

*130. Matthews M, Watkins D, Darbyshire A, Carson W, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Protects the Intestines from Radiation Therapy-Induced Intestinal Injury. J Pediatr Surg 48:1316-1322, June 2013. PMCID:PMC23845625 .

*131. Watkins D, Yang J, Matthews M, Besner G: Synergistic Effects of HB-EGF and Mesenchymal Stem Cells in a Murine Model of Intestinal Ischemia/Reperfusion Injury. J Pediatr Surg 48:1323-1329, June 2013. PMCID:PMC23845626.

*132. Lutmer J, Watkins D, Chen C-L, Velten M, Besner G: Heparin-Binding EGF-Like Growth Factor Attenuates Acute Lung Injury and Multi-Organ Dysfunction Following Scald Burn Injury in Mice. J Surg Res 185:329-337, Nov 2013. (Epub 2013 June 12) PMCID:PMC23777985.

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*133. Pelley TJ, Brown Kirschman KJ, Odar C, Butz C, Rye M, Fabia R, Besner G: The Development and Preliminary Validation of the Psychosocial Adjustment to Burn Questionnaire. Clinical Practice in Pediatric Psychology 1:171-183, 2013.

*134. Boomer L, Liu Y, Mahler N, Johnson J, Zak K, Nelson T, Lannutti J, Besner G: Scaffolding for Challenging Environments: Materials Selection for Tissue Engineered Intestine. J Biomedical Materials Research A 102(11):3795-3802, November 2013. (Epub Dec 12, 2013) PMCID:PMC24288210.

*135. Zhou Y, Yang J, Watkins D, Boomer L, Matthews M, Su Y, Besner G: Enteric Nervous System Abnormalities are Present in Human Necrotizing Enterocolitis: Potential Neurotransplantation Therapy. Stem Cell Research and Therapy 4(6):157-169, December 2013. (Epub Dec 25, 2013) PMCID:PMC24423414. Winner of the 2014 BioMed Central Translational Research Award

*136. Yang J, Su Y, Zhou Y, Besner G: Heparin-binding EGF-like Growth Factor Therapy for Intestinal Injury: Application and Future Prospects. Pathophysiology 21(1):95-104, February 2014. (Epub December 15, 2013). PMCID:PMC3961526.

*137. Wei J, Lin N, Xia X, Chen X, Peng F, Besner G, Feng J: Effects of Lipopolysaccharide-Induced Inflammation on the Interstitial Cells of Cajal. Cell Tissue and Research 356(1):29-37, April 2014. (Epub Jan 17, 2014) PMCID:PMC24435644.

*138. Su Y and Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Promotes Cell Migration and Adhesion via Focal Adhesion Kinase. J Surg Res 189(2):222-231, June 2014. (EPub 2014 March 3) PMCID:PMC24703506.

*139. Chen C-L, Yang J, James IO, Zhang H-Y, Besner G: Heparin-binding EGF-like Growth Factor Restores Wnt/-catenin Signaling in Intestinal Stem Cells Exposed to Ischemia/Reperfusion Injury. Surgery 155(6):1069-1080, June 2014. (EPub 2014 February 6) PMCID:PMC24856127.

*140. Watkins D, Zhou Y, Besner G: HB-EGF Augments the Ability of Mesenchymal Stem Cells to Attenuate Intestinal Injury. J Pediatr Surg 49(6):938-944, June 2014. (EPub 2014 January 31) PMCID:PMC24888839.

*141. Boomer L, Deans K, Minneci P, Cooper J, Besner G: Does Delay in Appendectomy Affect Surgical Site Infection in Children With Appendicitis? J Pediatr Surg 49(6):1026-1029, June 2014. (EPub 2014 February 5) PMCID:PMC24888856.

*142. Muszynski JA, Nofziger R, Greathouse K, Nateri J, Hanson-Huber, L, Steele L, Nicol K, Groner JI, Besner GE, Raffel C, Geyer S, El-Assal O, Hall MW: Innate Immune Function Predicts the Development of Nosocomial Infection in Critically Injured Children. Shock 42(4):313-321, October 2014. PMCID:PMC24978895.

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*143. Yang J, Su Y, Besner G: Stem Cell Therapy for Necrotizing Enterocolitis: Innovative Techniques and Procedures for Pediatric Translational Research. Methods Mol Biol 1213:121-137, 2014. PMCID:PMC25173379.

144. Thakkar R, Besner G: The Acute Abdomen. HeartBeat, 2014.

145. Besner G: A Pain in the NEC: Research Challenges and Opportunities. J Pediatr Surg 50(1):23-29, January 2015. (Epub 2014 Nov 7) PMCID:PMC25598088.

146. Harrison M, Emmamaullee J and Besner G: Profiles in Surgical Research: Michael R. Harrison, MD, FACS. Bull Am Coll Surg, 100(1):35-40, January 2015. PMCID:PMC25626264.

*147. Raval M, Rust L, Thakkar R, Kurtovic K, Nwomeh B, Besner G, Kenney B: Development and Implementation of an Electronic Health Record Generated Surgical Handoff and Rounding Tool. J Medical Systems 39(2):202-210, February 2015. PMCID:PMC25631842.

*148. Boomer L, Watkins, D, O’Donovan, J, Kenney, B, Besner, G: An Unusual Case of Foreign Body Pulmonary Embolus: A Case Report and Review of the Literature. J Pediatr Surg Int 31(3):241-247, March 2015. PMCID:PMC25633156.

*149. Wei J, Zhou Y, Besner G: M1 to M2 Macrophage Polarization in Heparin-Binding EGF-Like Growth Factor Therapy for Necrotizing Enterocolitis. J Surg Res 197(1):126-138, March 2015 (Epub 2015 Mar 18). PMCID:PMC25913486.

150. Longaker M, Emmamaullee J and Besner G: Profiles in Surgical Research: Michael R. Longaker, MD, MBA, FACS. Bull Am Coll Surg, 100(4):30-34, April 2015. PMCID:PMC25939202.

*151. Wei J, Zhou Y, Besner G: Heparin-Binding EGF-like Growth Factor and Enteric Neural Stem Cell Transplantation in the Prevention of Experimental Necrotizing Enterocolitis in Mice. Pediatric Research 78(1):29-37, July 2015. (EPub 2015 Mar 25) PMCID:PMC25806716.

152. Emmamaullee J and Besner G: Profiles in Surgical Research: Dorey L. Segev, MD, PhD, FACS. Bull Am Coll Surg, 100(7):27-33, July 2015. PMCID:PMC26248397.

*153. Liu Y, Rager T, Johnson J, Enmark J, and Besner G: Enriched Intestinal Stem Cell Seeding Improves the Architecture of Tissue Engineered Intestine. Tissue Eng Part C Methods 21(8):816-824, August 2015 (Epub 2015 Mar 12) PMCID:PMC25603285.

*154. Cromeens B, Brilli R, Kurtovic K, Kenney B, Nwomeh B, Besner G: Implementation of a Pediatric Surgical Quality Improvement (QI)-Driven M&M Conference. J Pediatr Surg 51:137-142. January 2016. PMCID:PMC26581322.

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*155. Zhou Y and Besner G: Transplantation of Amniotic Fluid Derived Neural Stem Cells as a Potential Novel Therapy For Hirschsprung’s Disease. J Pediatr Surg 51(1):87-91, Jan 2016. PMCID:PMC26597391.

*156. Zhang H-Y, Besner G, Feng J: Antibody Blockade of MAdCAM-1 Attenuates Pro-Inflammatory Activity of Mesenteric Lymph after Hemorrhagic Shock and Resuscitation. Surgery 159(5):1449-1460, May 2016. EPub Jan 21, 2016. PMCID:PMC26804820.

*157. Boomer L, Cooper J, Anandalwar S, Fallon S, Ostlie D, Leys C, Rangel S, Mattei P, Sharp S, St. Peter S, Rodriguez R, Kenney B, Besner G, Deans MD K, Minneci P: Delaying appendectomy does not lead to higher rates of surgical site infections: A multi-institutional analysis of children with appendicitis. Ann Surg 264(1):164-168, July 2016. PMCID:PMC26692077.

*158. Olson J, Rager T, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Harvesting the Benefits of Biofilms: A Novel Probiotic Delivery Method for the Prevention of Necrotizing Enterocolitis. J Pediatr Surg 51(6):936-941, June 2016. EPub June 2, 2016. PMCID:PMC27032609.

*159. Rager T, Olson J, Besner G: Exosomes Secreted from Bone Marrow-Derived Mesenchymal Stem Cells Protect Intestines from Experimental NEC. J Pediatr Surg 51(6):942-947, June 2016. EPub March 2, 2016. PMCID:PMC27015901.

*160. Cromeens B, Liu Y, Johnathan Stathopoulos, Wang Y, Jed Johnson, Besner G: Production of Tissue Engineered Intestine from Expanded Enteroids. J Surg Res 204(1):164-175, July 2016. EPub March 3, 2016. PMCID:PMC27451883.

Winner, Best Manuscript of a New Association of Academic Surgery Member

*161. Liu Y, Nelson T, Cromeens B, Rager T, Lannutti J, Johnson J, Besner G: HB-EGF Embedded in PGA Scaffolds via Subcritical CO2 Augments the Growth of Tissue Engineered Intestine. Biomaterials 103:150-159, Oct 2016. EPub June 21, 2016. PMCID:PMC27380441.

162. Olson J, Powell D, Hirschl R, Besner G: Necrtizing Enterocolitis. APSA Not a

Textbook.

*163. Zhou Y, Watkins D, Besner G: The Role of Vascular Development in the Pathogenesis of Necrotizing Enterocolitis. In Necrotizing Enterocolitis: New Insights into Diagnosis, Pathogenesis, and Treatment (in press).

*164. Rager T and Besner G: The Role of Growth Factor Signaling in the Development and Treatment of Necrotizing Enterocolitis. In Necrotizing Enterocolitis: New Insights into Diagnosis, Pathogenesis, and Treatment (in press).

165. Itani K and Besner G: The First First Joan L. and Julius H. Jacobson Promising Investigator Awardee, Michael T. Longaker MD, FACS, Journal of the American College of Surgeons (in press).

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166. Burkey, B and Besner G: Pediatric Burn Management. Fundamentals of Pediatric Surgery, Chapter 20. Peter Mattei (ed). (in press).

167. Shen S, Zhao Z, Wang H, YilinHan, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Ray W, Hoehne B, Xu R: Freeform Fabrication of Tissue-Simulating Phantoms by Combining Three-Dimensional Printing and Casting. Proceedings of the Design and Quality for Biomedical Technologies IX Conference, Photonics West (in press).

*168. Shen J, PhD, Giles S, Kurtovic K, Fabia R, Besner G, Wheeler K, Xiang H, Groner J: Evaluation of Nurses’ Accuracy in Rating Procedural Pain among Pediatric Burn Patients using the Face, Legs, Activity, Cry, Consolability (FLACC) Scale. Burns (in press).

*169. Cromeens B, Leonard J, Governale L, Kirschner R, Pearson G, Levitt M, Wood R, Thakkar R, Islam M, Mckinney J, Whitaker, E, Bryant J, Adler B, Ray W, Hoehne B, Besner G: The Separation of Pygopagus Conjoined Twins with Fused Spinal Cords and Imperforate Anus. Journal of Pediatric Surgery Case Reports (in press).

*170. Kamata M, Whitaker E, Bryant J, Besner G, Leonard J, Pearson G, Levitt M, Tobias J: Anesthetic Management of Pygopagus Conjoined Twins: Techniques to Evaluate Cross-Circulation. International Journal of Clinical and Experimental Medicine. (in press).

*171. Johnson S, Shi J, Groner J, Thakkar R, Fabia R, Besner G, Xiang, H, Wheeler K: Inter-Facility Transfer of Pediatric Burn Patients in US Emergency Departments. Burns (in press).

*172. Cromeens B, McKinney J, Brown J, Henry C, Leonard J, Governale L, Besner G, Islam M: Pygopagus Conjoined Twins: A Neurophysiologic Intraoperative Monitoring Schema. J Clin Neurophysiology (in press).

*173. Zhou Y, Wang Y, Olson J, Yang J, Besner G: Heparin-Binding EGF Like Growth Factor Promotes Neuronal Nitric Oxide Synthase Expression and Protects the Enteric Nervous System after Necrotizing Enterocolitis. Pediatric Res (submitted)

*174. Cromeens B, Ray W, Hoehne B, Abayneh F, Adler B, Besner G: Facilitating Surgeon Understanding of Complex Anatomy Using a 3D Printed Model. Surgery (submitted).

*175. McCulloh C, Olson J, Zhou Y, Wang Y, Besner G: Stem Cells and Necrotizing Enterocolitis: A Direct Comparison of the Efficacy of Multiple Types of Stem Cells. J Pediatr Surg (submitted).

*176. Cromeens B, Wang Y, Besner G: ISEMF are Recruited into Tissue Engineered Intestine. J Surg Res (in preparation).

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*177. Cromeens B, Lisciandro R, Brilli R, Askegard-Giesmann J, Kenney B, Besner G: Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity & Mortality Conference to the National Surgical Quality Improvement Program-Pediatric (NSQIP-P) System. JACS (in preparation).

*178. Zhou Y and Besner G: Profiling of Circulating Exosomal MicroRNAs in Neonatal Necrotizing Enterocolitis. Surgery (in preparation).

*179. Zhou Y and Besner G: Neural Stem Cell-Derived Exosomes Target Injured Neurons and Protect the ENS from Necrotizing Enterocolitis. Surgery (in preparation).

*180. Zhou Y, Markmann K, Besner G: Over-expression of HB-EGF Protects Intestinal Myenteric Plexus Neurons Subjected to Ischemia/Reperfusion Injury (in preparation).

*181. Chen C-L, Otabor I, Zhou Y, Chen Y, El-Assal O, Paddock H, Feng J, Wu D, Mehta V, Besner G: Characterization of Gastrointestinal Tract Abnormalities in HB-EGF Knockout Mice. J Surg Res (in preparation).

Video Abstracts

1. Besner G: Heparin-Binding EGF-like Growth Factor Increases Intestinal Microvascular Blood Flow in Necrotizing Enterocolitis. Hosted by the American Gastroenterology Association on YouTube, May, 2009 (http://www.youtube.com/watch?v=84zsbXDEgL8).Video abstract by invitation from on-line editor of Gastroenterology

Published Abstracts

* indicates peer-review

*1. Besner G and Klagsbrun M: Characterization and Purification of a Heparin-Binding Growth Factor from Mononuclear Cell Conditioned Medium. J Cell Biol 107 (6, Pt 3):481a, 1989.

*2. Besner G, Whelton D, Crissman-Combs M, Steffen C, Kim G, Brigstock D: "Heparin-Dependence of the Interaction of Heparin-Binding EGF-Like Growth Factor with the EGF Receptor". Mol Biol Cell 3 (Supplement) H22, 1992.

*3. Crissman-Combs M, Brigstock D, Besner G: Production and Characterization of Recombinant Human HB-EGF in Eschericia Coli. Mol Biol Cell 4 (Supplement) A109, 1993.

*4. McCarthy D, Brigstick D, Cooney D, Besner G: Human Burn Wound Fluid Contains HB-EGF-Like and PDGF-Like Factors. Mol Biol Cell 4 (Supplement) A113, 1993.

*5. Brigstock D, Steffen C, Abad M, Besner G, Kim, G: Heparin-binding EGF-like growth factor is a constituent of pig uterine luminal flushings. Biol Reprod 50 (Supplement 1) A332, 1994.

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*6. Downing M, Brigstock D, McCarthy D, Brown K, Luquette M, Besner G: Immunodetection of heparin-binding EGF-like growth factor in multiple epithelial tissues. Mol Biol Cell 5 (Supplement) A118, 1994.

*7. Davis KM, Brigstock DR, Johnson PR, Besner GE: Production of Heparin-Binding EGF-Like Growth Factor in HeLa Cells Using a Vaccinia Viral Vector System. Mol Biol Cell 6 (Supplement) A44, 1995.

*8. Harding PA, Brigstock DR, Shen L, Crissman-Combs MA, Besner GE: Structural Organization of the Gene For Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF). Mol Biol Cell 6 (Supplement) A1760, 1995.

*9. Downing M, Brigstock D, Luquette M, Besner G: Immunohistochemical Localization of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Epithelial Tissues. Mol Biol Cell 7 (supplement) A122, 1996.

*10. Crissman-Combs M, Brigstock D, Besner G: Production and Characterization of a Recombinant High Molecular Weight Form of Human Heparin-Binding EGF-Like Growth Factor (HB-EGF). Mol Biol Cell 7 (supplement) A121, 1996.

*11. Harding P, Brigstock D, Crissman-Combs M, Besner G: Functional Expression of Human HB-EGF cDNA in Mouse L Cells. Mol Biol Cell 7 (supplement) A127, 1996.

*12. Crissman-Combs M, Downing M, Brigstock D, Luquette M, Besner G: Immunohistochemical Localization of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Diseased Skin. Mol. Biol. Cell 8, A1395, 1997.

*13. Pillai S, Turman M, Besner G: The Cytoprotective Effects of Heparin-Binding EGF-Like Growth Factor (HB-EGF) on Intestinal Epithelial Cells Exposed to Hypoxia. Mol. Biol. Cell 8, A1394, 1997.

*14. Pillai S, Luquette M, Nowicki P, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Intestinal Injury After Ischemia. Mol. Biol. Cell 8, A46, 1997.

*15. Davis–Fleischer K, Harding P, Brigstock D, Besner G: An Analysis of O-glycosylation in Human Heparin-Binding EGF-Like Growth Factor (HB-EGF). Mol. Biol. Cell 8, A100, 1997.

*16. Hinman C, Downing M, Luquette M, Besner G: A Model for Intestinal Ischemia/Reperfusion Injury in Weanling Rats. J Investig Surg 12, 214, 1999.

*17. Mehta V, Besner G: Heparin-Binding EGF-like Growth Factor (HB-EGF) Suppresses NF-B Activation and Decreases Nitric Oxide Production. Pediatric Research, 53, 170A, 2003.

*18. El-Assal O, Nowicki P, Besner G: Expression of HB-EGF within Intestine Resected for Necrotizing Enterocolitis (NEC). Pediatric Research, 55, 540A, 2004.

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*19. Mehta V and Besner G: HB-EGF Mediated Inhibition of NF-kB Activation and Nitric Oxide Production in Intestinal Epithelial Cells is Mediated by the PI3-Kinase Signaling Pathway. Pediatric Research, 55, 465A, 2004.

*20. Corpron C, Martin A, Roberts G, Besner G: The Pediatric Burn Unit: A Profit Center. Yearbook of Surgery, Mosby, 2005.

*21. Mehta V and Besner G: Activation of the PI3-Kinase Pathway Mediates Heparin-Binding EGF-Like Growth Factor (HB-EGF)–Induced Endothelial Cell Wound Healing and Angiogenesis. Pediatric Research, A, 2006.

*22. Rocourt D, Mehta V, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Pro-Inflammatory Cytokine Expression in the Intestine after Intestinal Ischemia/Reperfusion Injury. Pediatric Research, 55, 465A, 2006.

*23. El-Assal O, Radulescu A, Besner G: HB-EGF Protects against Damage and Enhances Restitution in Rats Subjected to Hemorrhagic Shock and Resuscitation. Journal of Surgical Research 137:161, 2007.

*24. El-Assal O, Besner G: HB-EGF Increases Intestinal Microvascular Blood Flow In Rats Subjected to Ischemia/Reperfusion Injury. Pediatric Research, 2007.

*25. Paddock H, El-Assal O, Besner G: HB-EGF Knockout Mice have Increased Intestinal Permeability after Intestinal Ischemia/Reperfusion Injury. Pediatric Research, 2007.

*26. Mehta V, Besner G: HB-EGF Promotes P38MAPK-Dependent Endothelial Cell Migration and Angiogenesis without Stimulating Proliferation. Pediatric Research, 2007.

*27. Radulescu A, Yu X, Zorko N, Orvets N, Khalfoun S, Besner G: Prophylactic Therapy for Necrotizing Enterocolitis Using Heparin-Binding EGF-Like Growth Factor. J Surg Res 151:205, 2009.

*28. Zhang H-Y, Radulescu A, Besner G: HB-EGF is Essential for Preservation of Gut Barrier Function after Hemorrhagic Shock and Resuscitation in Mice. J Surg Res 151:246, 2009.

*29. Zhou Y, Radulescu A, Chen Y, Besner G: Deletion of the Heparin-Binding EGF-Like Growth Factor Gene in Mice Impairs Intestinal Transit. Journal of the American College of Surgeons, October 2009.

*30. Zhang H-Y, Radulescu A, Chen Y, Besner G: Heparin-Binding EGF-like Growth Factor (HB-EGF) Improves Intestinal Microcirculation after Hemorrhagic Shock and Resuscitation in Mice. Journal of the American College of Surgeons, October, 2009.

*31. Radulescu A, Zhang H-Y, Chen C-L, Chen Y, Zhou Y, Olson J, Besner G: Expression Levels of Heparin-Binding EGF-Like Growth Factor Affect Intestinal Anastomotic Wound Healing. J Surg Res, 158:184-5, 2010.

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*32. Radulescu A, Zhang H-Y, Yu X, Olson J, Darbyshire A, Chen Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Overexpression in Transgenic Mice Increases Resistance to Necrotizing Enterocolitis. Journal of the American College of Surgeons, October, 2010.

*33. Chen C, James I, Yu X, Besner G: HB-EGF Protects Intestinal Stem Cells from Hypoxic Injury via the EGFR/PI3K/MAPK Pathway. Journal of Surgical Research, 165:261, 2011.

*34. Yang J, Chen C-L, Watkins D, Zhang H-Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) and Mesenchymal Stem Cells (MSC) Act Synergistically to Prevent Experimental Necrotizing Enterocolitis. Journal of the American College of Surgeons, October, 2011.

*35. Besner G, Yang J, Watkins D, Zhou Y, Chen C-L: Heparin-binding EGF-like Growth Factor to Prevent Necrotizing Enterocolitis. Journal of Pediatric Research, 2012.

*36. Liu Y, Rager T, Lannutti J, Johnson J, Painter P, Nelson T, Enmark J, Besner G: Enriched Intestinal Stem Cell Seeding Improves the Architecture of Tissue Engineered Intestine. TISSUE ENGINEERING: Part A, Volume 20, Supplement 1, 2014: S-51.

*37. Liu Y, Rager T, Cromeens B, Johnson J, Chakroff J, Besner G: Comparison of Different in vivo Incubation Sites for Production of Tissue Engineered Intestine (TEI), TISSUE ENGINEERING: Part A, Volume 21, Supplement 1, 2015: S-99.

*38. Gartner S, Olson J, McCulloh C, Besner G: Utilizing the Benefits of Biofilms: Prevention of Necrotizing Enterocolitis Using a Novel Probiotic Delivery System. Florida Pediatrician, 2016.

Editorial Letters

1. Besner G, Vegunta R: Reply to Letter-to-the-Editor regarding “Collision Tumors in Children: A Review of the Literature and Presentation of a Rare Case of Mesoblastic Nephroma and Neuroblastoma in an Infant“, J Pediatr Surg, October 2001.

2. Besner G and Gittes G: Preface to “Progress in Pediatric Research” issue, Seminars in Pediatric Surgery, March 2004.

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PRESENTATIONS

National and International

1. Besner G, and Klagsbrun M: Characterization and Purification of a Heparin-Binding Growth Factor from Mononuclear Cell Conditioned Medium. Thirty-First Annual Meeting of the American Society of Cell Biology - American Society of Biochemistry and Molecular Biology Joint Meeting, San Francisco, California, February 1989. Presented by Dr. Besner.

2. Besner G and Klagsbrun M: A Novel Macrophage-Secreted Growth Factor and Its Possible Role in the Regulation of Angiogenesis. Tenth Annual Pediatric Surgical Residents' Conference, Buffalo, New York, October 1989. Read by Dr. Besner.

3. Klagsbrun M, Higashiyama S, Besner G: Modulation of Vascular Cell Proliferation by FGF and other Heparin-Binding Growth Factors. The First International Congress on Inflammation, Barcelona, Spain, June 1990. Read by Dr. Klagsbrun.

4. Stannard V, Robinson L, Besner G, Glick P, Allen J, Karp M, Jewett T, Cooney D: Familial Hirschprung's Disease (First Report of Recessive X-Linked Autosomal Dominant Kindreds). British Association of Pediatric Surgeons, Glascow, Scotland, July 1990. Read by Dr. Stannard.

5. Besner G, Klagsbrun M, Folkman J: Macrophages Secrete a Novel Endothelial Cell Inhibitor: Possible Roles in Angiogenesis. Forty-Second Annual Meeting of the American Academy of Pediatrics, Surgical Section, Boston, Massachusetts, October 1990. Read by Dr. Besner.

6. Besner G, Stannard V, Cooney D, Glick P: Surfactant Replacement for the High Risk Neonate with CDH. Eleventh Annual Pediatric Surgical Residents' Conference, Chicago, Illinois, November 1990. Read by Dr. Besner.

7. Glick P, Leach C, Besner G, Morin F, Allen J, Cooney D, et al: Surfactant Replacement for the High Risk Neonate with CDH. American Thoracic Society, American Lung Association, International Conference, Anaheim, California, May 1991. Read by Dr. Glick.

8. Besner G, Glick P, Karp M, Whang W, Lobe T, Allen J, Jewett T, Cooney D: rhG-CSF Promotes Wound Healing in a Patient with Congenital Neutropenia (CN). Twenty-Second Annual Meeting of the American Pediatric Surgical Association, Lake Buena Vista, Florida, May 1991. Read by Dr. Besner.

9. McCarthy D, Brigstock D, Besner G: A New Aspect in The Wound Healing Module -Heparin-Binding Epidermal Growth Factor (HB-EGF): What Role Does Heparin Binding Play? Thirteenth Annual Pediatric Surgery Residents' Conference, Kansas City, Missouri, October, 1992. Read by Dr. McCarthy.

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10. Besner G, McCarthy D, Brigstock D: Heparin-Binding Epidermal Growth Factor (HB-EGF): A Novel Growth Factor With Potential Cytoprotective Effects. Fourth International Wexner Symposium: Peptide Therapies in Developmental Gastroenterology and Nutrition, Columbus, Ohio, October, 1992. Presented by Drs. Besner and Brigstock.

11. Besner G, Whelton D, Crissman-Combs M, Steffen C, Kim G, Brigstock D: Heparin-Dependence of the Interaction of Heparin-Binding EGF-Like Growth Factor with the EGF Receptor. Thirty-Second Annual Meeting of the American Society for Cell Biology, Denver, Colorado, November, 1992. Presented by Drs. Besner and Brigstock.

12. Martinez D, Mojzisik C, Martin E, Sampsel J, Olson J, Qualman S, Chen F, Besner G, Caniano D, Wray D, O'Dorisio T, O'Dorisio S: Use of Somatostatin Analogs in Detection of Neuroblastoma. Society of Surgical Oncology, Los Angeles, California, March, 1993. Read by Dr. Martinez.

13. Besner G and Keels E: Prenatal Recognition and Education Program. Genetics in the 90s Conference: The Perinatal Patient, Columbus, Ohio, April, 1993. Read by Dr. Besner.

14. McCarthy D, Brigstock D, Besner G: Heparin-Binding Epidermal Growth Factor (HB-EGF) - New Implications in Wound Healing. Fifth Annual Meeting of the Robert M. Zollinger Surgical Society, Columbus, Ohio, May, 1993. Read by Dr. McCarthy.

15. Besner G: Introduction to Heparin-Binding Epidermal Growth Factor (HB-EGF). The First Annual H. William Clatworthy Oration, Columbus, Ohio, May 1993. Read by Dr. Besner.

16. McCarthy D, Qualman S, Besner G: Absent Intestinal Musculature. Twenty-Fourth Annual Meeting of the American Pediatric Surgical Association, Hilton Head, South Carolina, May, 1993. Presented by Dr. McCarthy.

17. McCarthy, D, Brigstock D, Cooney D, Besner, G: Human Burn Wound Fluid Contains Heparin-Binding EGF-Like Growth Factor (HB-EGF) and Platelet-Derived Growth Factor (PDGF). Fourteenth Annual Pediatric Surgery Residents' Conference, Montreal, Quebec, Canada, October, 1993. Read by Dr. McCarthy.

18. Vegunta R, Brigstock D, Besner G, Cooney, D: Specific Protein Expression by a Metastasizing Clone of Murine Neuroblastoma. Fourteenth Annual Pediatric Surgery Residents' Conference, Montreal, Quebec, Canada, October, 1993. Read by Dr. Vegunta.

19. Ismail N, Steffen C, Vegunta R, Kim G, Besner G, Cooney D, Brigstock D: Epidermal Growth Factor in Uterine Fluids. Fourteenth Annual Pediatric Surgery Residents' Conference, Montreal, Quebec, Canada, October, 1993. Read by Dr. Ismail.

20. Besner G: Heparin-Binding EGF-Like Growth Factor. Pediatric Surgery Biology Club Meeting, San Francisco, California, October, 1993. Read by Dr. Besner.

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21. Crissman-Combs M, Brigstock D, Besner G: Production and Characterization of Recombinant Human HB-EGF in Escherichia Coli. Thirty-Third Annual Meeting of the American Society for Cell Biology, New Orleans, Louisiana, December, 1993. Presented by Dr. Brigstock.

22. McCarthy D, Brigstock D, Besner G: Human Burn Wound Fluid Contains HB-EGF-Like and PDGF-Like Growth Factors. Thirty-Third Annual Meeting of the American Society for Cell Biology, New Orleans, Louisiana, December, 1993. Presented by Dr. McCarthy.

23. Besner G, Brigstock D, McCarthy D: Human Burn Wound Fluid Contains Two Distinct Heparin-Binding Growth Factors. Twenty-Sixth Annual Meeting of the American Burn Association, Orlando, Florida, April, 1994. Read by Dr. Besner.

24. McCarthy D, Brigstock D, Besner G: Purification of a Novel Growth Factor From Human Urine. Sixth Annual Meeting of the Robert M. Zollinger Surgical Society,

Columbus, Ohio, April, 1994. Read by Dr. McCarthy.

25. Vegunta R, Cooney D, Besner G, Brigstock D: Comparative Protein Expression by C1300 Murine Neuroblastoma and its Metastasizing Clone, TBJ. Twenty-fifth Annual Meeting of the American Pediatric Surgical Association, Tuscon, Arizona, May, 1994. Presented by Dr. Vegunta.

26. Mutabagani K, Beaver B, Cooney C, Besner G: Penetrating Neck Trauma in Children: A Reappraisal. Twenty-Fifth Annual Meeting of the American Pediatric Surgical Association, Tuscon, Arizona, May 1994. Read by Dr. Mutabagani.

27. Mutabagani K, Beaver B, Cooney C, Besner G: Penetrating Neck Trauma in Children: A Reappraisal. Trauma Session of the American College of Surgeons, Dayton, Ohio, May 1994. Read by Dr. Mutabagani.

28. Brigstock D, Steffen C, Abad M, Besner G, Kim G: Heparin-Binding EGF-Like Growth Factor is a Constituent of Pig Uterine Luminal Flushings. Twenty-Seventh Annual Meeting of the Society for the Study of Reproduction, Ann Arbor, Michigan, July, 1994. Read by Dr. Brigstock.

29. Ruymann F, Newton W, Hutchinson C, Besner G, Qualman S: Non-Rhabdomyosarcomatous Soft Tissue Tumors of Children and Adolescents. Seventh Annual Meeting of The American Society of Pediatric Hematology/Oncology, Chicago, Illinois, October 1994.

30. Downing M, Brigstock D, Luquette M, Besner G: Immunohistochemical Detection of Heparin-binding EGF-like Growth Factor in Epithelia. Fifteenth Annual Pediatric Surgery Residents' Conference, Brooklyn, New York, November, 1994. Read by Dr. Downing.

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31. Downing M, Hamoudi A, Besner G: Brain Heterotopia: Choristoma of the Back. Fifteenth Annual Pediatric Surgery Residents' Conference, Brooklyn, New York, November, 1994. Presented by Dr. Downing.

32. Mutabagani K, Beaver B, Cooney C, Besner G: Penetrating Neck Trauma in Children: A Reappraisal. Fifteenth Annual Pediatric Surgery Residents' Conference, Brooklyn, New York, November, 1994. Presented by Dr. Mutabagani.

33. Downing M, Brigstock D, McCarthy D, Brown K, Luquette M, Besner G: Immunohistochemical Detection of Heparin-binding EGF-like Growth Factor in Multiple Epithelia. Thirty-Fourth Annual Meeting of the American Society for Cell Biology, San Francisco, California, December, 1994. Presented by Dr. Downing.

34. Besner G, Qualman S, Gosche J: Identification of a Duplicated Undescended Testicle -An Unexpected Benefit of Laparoscopic Localization. IV International Congress for Endosurgery in Children, Orlando, Florida, May, 1995. Presented by Dr. Besner.

35. Mutabagani K, Beaver B, Cooney D, Besner G: Penetrating Neck Trauma in Children -A Reappraisal. Seventh Annual Meeting of the Zollinger Surgical Society, Columbus, Ohio, September, 1995. Read by Dr. Mutabagani.

36. Downing MT, Brigstock DR, Besner GE: Immunohistochemical Detection of Heparin-Binding EGF-Like Growth Factor in Multiple Epithelial Tissues. Seventh Annual Meeting of the Zollinger Surgical Society, Columbus, Ohio, September, 1995. Read by Dr. Downing.

37. Downing MT, McCarthy DW, Brigstock DR, Luquette, MH, Besner GE: Production of Heparin-Binding EGF-Like Growth Factor (HB-EGF) at Sites of Thermal Injury. Growth Factors and Wound Healing Symposium: Basic Science and Potential Clinical Applications. Serono Symposium, Boston, Massachusetts, September 29, 1995. Presented by Dr. Besner.

38. Cribbs R, Besner G, Caniano D, Cooney D: Appropriate Fluid Management For Infants With Abdominal Wall Defects. Forty-Seventh Annual Meeting of the American Academy of Pediatrics, Surgical Section, San Francisco, California, October 14, 1995. Presented by Dr. Cribbs.

39. Cribbs R, Luquette M, Cooney D, Besner G: HB-EGF Expression During Murine Partial-Thickness Burn Wound Healing. Sixteenth Annual Pediatric Surgery Residents' Conference, Oklahoma City, Oklahoma, November, 1995. Presented by Dr. Cribbs.

40. Downing M, Brigstock D, Besner G: Immunohistochemical Survey of Epithelial Tissues and Tumors for the Presence of Heparin-Binding EGF-Like Growth Factor (HB-EGF). Sixteenth Annual Pediatric Surgery Residents' Conference, Oklahoma City, Oklahoma, November, 1995. Presented by Dr. Downing.

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41. Harding PA, Brigstock DR, Shen L, Crissman-Combs MA, Besner GE: Structural Organization of the Gene For Murine Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF). Thirty-Fifth Annual Meeting of The American Society for Cell Biology, Washington, DC, December, 1995. Presented by Dr. Harding.

42. Davis KM, Brigstock DR, Johnson PR, Besner GE: Production of Heparin-Binding EGF-Like Growth Factor Using a Vaccinia Viral Vector System. Thirty-Fifth Annual Meeting of The American Society for Cell Biology, Washington, DC, December, 1995. Presented by Dr. Davis.

43. Bensard D, Beaver B, Besner G, Cooney D: Small Bowel Injury in Children Sustaining Blunt Abdominal Trauma: Is Delayed Diagnosis Important? Twenty-Sixth Annual Scientific Meeting of The Western Trauma Association, Grand Targhee, WY, Feb 1996. Read by Dr. Bensard.

44. Besner G: Studies of the Roles of HB-EGF in Cancer. Fortieth Anniversary Group Meeting of the Children's Cancer Group, Vancouver, Canada, April 25, 1996. Read by Dr. Besner.

45. Harding P, Brigstock D, Crissman-Coombs M, Besner G: Functional Expression of Human HB-EGF cDNA in mouse L Cells. Gordon Research Conference on Peptide Growth Factors, Kimball Union Academy, NH, August, 1996. Presented by Dr. Harding.

46. Cribbs R, Luquette M, Besner G: HB-EGF Expression is Associated with Healing of Murine Partial Thickness Burn Wounds. Eighth Annual Zollinger Society Meeting, Columbus, Ohio, September, 1996. Read by Dr. Cribbs.

47. Cribbs R, Luquette M, Besner G: HB-EGF Production is Associated With Re-Epithelialization of Murine Partial Thickness Burn Wounds. Forty-Eighth Annual Meeting of the American Academy of Pediatrics, Surgical Section, Boston, MA, October, 1996. Presented by Dr. Cribbs.

48. Downing M, Brigstock D, Luquette M, Besner G: Immunohistochemical Localization of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Epithelial Tissues. Sixth International Congress on Cell Biology/36th American Society for Cell Biology Annual Meeting, San Francisco, California, December, 1996. Presented by Dr. Besner.

49. Crissman-Combs M, Brigstock D, Besner G: Production and Characterization of a Recombinant High Molecular Weight Form of Human Heparin-Binding EGF-Like Growth Factor (HB-EGF). Sixth International Congress on Cell Biology/36th American Society for Cell Biology Annual Meeting, San Francisco, California, December, 1996. Presented by Dr. Besner.

50. Harding P, Brigstock D, Crissman-Combs M, Besner G: Functional Expression of Human HB-EGF cDNA in Mouse L Cells. Sixth International Congress on Cell Biology/Thirty-Sixth Annual Meeting of the American Society for Cell Biology, San Francisco, California, December, 1996. Presented by Dr. Besner.

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51. Cribbs R, Luquette M, Besner G: Topical Application of HB-EGF Promotes Epithelial Cell Proliferation and Wound Re-epithelialization in Partial Thickness Burns. Thirty-Ninth Annual University Surgical Residents' Conference, Society of University Surgeons, Tampa, Florida, February, 1997. Presented by Dr. Cribbs.

52. Cribbs R, Luquette R, Besner G: Acceleration of Partial-Thickness Burn Wound Healing with Topical Application of HB-EGF. Twenty-Ninth Annual Meeting of the American Burn Association, New York, New York, March, 1997. Read by Dr. Cribbs

53. Pillai S, Turman M, Besner G: Cytoprotective Effects of HB-EGF on Intestinal Epithelial Cells. American Academy of Pediatrics, Surgical Section, New Orleans, Louisiana, November, 1997. Read by Dr. Pillai.

54. Bethel C, Mutabagani K, Hammond S, Besner G, Caniano D, Cooney D: Non-Teratomatous Germ Cell Tumors in Children. American Academy of Pediatrics, Surgical Section, New Orleans, Louisiana, November, 1997. Read by Dr. Bethel.

55. Crissman-Combs M, Downing M, Brigstock D, Luquette M, Besner G: Immunohistochemical Localization of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Diseased Skin. Thirty-Seventh Annual Meeting of the American Society for Cell Biology, Washington, DC, December, 1997. Presented by Dr. Brigstock.

56. Pillai S, Turman M, Besner G: The Cytoprotective Effects of Heparin-Binding EGF-Like Growth Factor (HB-EGF) on Intestinal Epithelial Cells Exposed to Hypoxia. Thirty-Seventh Annual Meeting of the American Society for Cell Biology, Washington, DC, December, 1997. Presented by Dr. Pillai

57. Pillai S, Luquette M, Nowicki P, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Intestinal Injury After Ischemia. Thirty-Seventh Annual Meeting of the American Society for Cell Biology, Washington, DC, December, 1997. Presented by Dr. Pillai.

58. Davis–Fleischer K, Harding P, Brigstock D, Besner G: An Analysis of O-glycosylation in Human Heparin-Binding EGF-Like Growth Factor (HB-EGF). Thirty-Seventh Annual Meeting of the American Society for Cell Biology, Washington, DC, December, 1997. Presented by Dr. Davis-Fleischer.

59. Pillai S, Bethel C, Besner G, Caniano D, Cooney D: Fall Injuries in the Pediatric Population: Safer and More Cost-Effective Management. Eleventh Annual Meeting of the Eastern Association for the Surgery of Trauma, Sanabelle Island, Florida, January, 1998. Read by Dr. Pillai.

60. Pillai S, Luquette M, Nowicki P, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Small Intestinal Ischemia/Reperfusion Injury in Rats. Fortieth Annual University Surgical Residents’ Conference, Society of University Surgeons, Milwaukee, Wisconsin, February, 1998. Read by Dr. Pillai.

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61. Mutabagani K, Zumberge N, Coley B, Martin L, Shields W, McCarthy D, Besner G, Caniano D, Cooney D: Focused Abdominal Sonography for Trauma (FAST) in Children: Is it Useful? Twenty-Ninth Annual Meeting of the American Pediatric Surgical Association, Hilton Head, South Carolina, May, 1998. Read by Dr. Mutabagani.

62. Pillai S, Nowicki P, Luquette M, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Small Intestinal Ischemia/Reperfusion Injury in Rats. Twenty-Ninth Annual Meeting of the American Pediatric Surgical Association, Hilton Head, South Carolina, May, 1998. Read by Dr. Pillai.

63. Besner G: Necrotizing Enterocolitis – From Bench to Bedside. Ulleval Hospital, Department of Pediatrics and Surgery, Oslo, Norway, June 3, 1998. Read by Dr. Besner.

64. Besner G: Necrotizing Enterocolitis – From Bench to Bedside. Norwegian Pediatric Association, Hammerfest, Norway, June 4, 1998. Read by Dr. Besner.

65. McCarthy D, Pillai S, Bullock J, Hogan M, Coley B, Mutabagani K, Caniano D, Besner G, Cooney D: The Value and Cost Effectiveness of Grading CT Scans in Children When Managing Liver and Spleen Injuries. British Association of Pediatric Surgery, Bristol, England, July, 1998. Presented by Dr. McCarthy.

66. Besner G: The Role of Heparin-Binding EGF-Like Growth Factor in the Treatment of Burn Wound Healing and Intestinal Ischemia-Reperfusion Injury. Shriner’s Hospital Lecture Series, Cincinnati, Ohio, February 18, 1999. Read by Dr. Besner.

67. Hinman C, Downing M, Luquette M, Besner G: A Model for Intestinal Ischemia/Reperfusion Injury in Weanling Rats. Fifteenth Annual Meeting of the Academy of Surgical Research, Scottsdale, Arizona, September, 1999. Read by Dr. Downing.

68. Besner G: The Triple Threat in the Twenty-first Century. The 3rd Annual Medical Scientist Student Forum, Columbus, Ohio, April 1999. Read by Dr. Besner.

69. Michalsky M, Lara-Marquez M, Chun L, Downing M, Besner G: Endogenous Heparin-Binding EGF-Like Growth Factor: A Potential Role in Fetal and Neonatal Gastrointestinal Physiology. Year 2000 Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting, Boston, Massachusetts, May, 2000. Presented by Dr. Michalsky.

70. Michalsky M, Lara-Marquez M, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Modulates Nitric Oxide Production in Intestinal Epithelial Cells. Year 2000 Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting, Boston, Massachusetts, May, 2000. Presented by Dr. Michalsky.

71. Klopfenstein K, Groner J, Besner G, Rauck A: Peripheral Blood Stem Cell Transplant in patients with Chemotherapy-Refractory Stage V Wilms’ Tumor. American Society of Pediatric Hematology/Oncology, Minneapolis. MN, September, 2000. Presented by Dr. Klopfenstein.

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72. Lara-Marquez M, Michalasky M, Xia G, Besner G: Inducible Nitric Oxide Synthase (iNOS) Gene Expression is Modulated by Heparin-Binding EGF-Like Growth Factor (HB-EGF in Human Intestinal Epithelial Cells. American Academy of Pediatrics 2000 Annual Meeting, Chicago, IL, Oct 2000. Presented by Dr. Lara-Marquez.

73. Michalsky M and Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Modulates Apoptosis in Intestinal Epithelial Cells in Vitro. American Academy of Pediatrics 2000 Annual Meeting, Chicago, IL, Oct 2000. Read by Dr.Michalsky.

74. Michalsky M, Kuhn A, Mehta V, Glenn S, Besner G: HB-EGF Decreases Leukocyte-Derived Oxygen Free Radical Production. Forty-first Annual University Surgical Residents’ Conference, Society of University Surgeons, Chicago, Illinois, February, 2001. Read by Dr. Michalsky.

75. Xia G, Besner G: Heparin-binding EGF-Like Growth Factor (HB-EGF) Decreases Inducible Nitric Oxide Synthase, Nitric Oxide and Nitrotyrosine Production After Intestinal Ischemia/Reperfusion Injury In Vivo. Year 2001 Pediatric Academic Societies Meeting, Baltimore, Maryland, April, 2001. Read by Dr. Xia.

76. Kuhn A, Michalsky M, Mehta V, Glenn S, Besner G: HB-EGF Decreases Leukocyte-Derived Oxygen Free Radical Production. American Pediatric Surgical Association, Naples, Florida, May 21, 2001. Read by Dr. Kuhn.

77. Besner G: HB-EGF and Intestinal Ischemia/Reperfusion Injury. Report to the American Pediatric Surgical Association Foundation, Naples, Florida, May 22, 2001. Read by Dr. Besner.

78. Xia G, Martin A, Michalsky M, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Presserves Crypt Cell Proliferation and Decreases Bacterial Translocation After Intestinal Ischemia/Reperfusion Injury. American Academy of Pediatrics 2001 National Conference and Exhibition, San Francisco, California, October, 2001. Read by Dr.Xia.

79. Kuhn A, Xia G, Besner G: The Effect of Heparin-Binding EGF-Like Growth Factor (HB-EGF) on Ischemia/Reperfusion Injury-Induced Oxygen Free Radical Production in Rats. American Academy of Pediatrics 2001 National Conference and Exhibition, San Francisco, California, October, 2001. Read by Dr. Kuhn.

80. Besner G: HB-EGF and Intestinal Ischemia/Reperfusion Injury. Invited speaker at Pediatric Surgery Grand Rounds, Yale Children’s Hospital, New Haven, Connecticut, January 29, 2002. Read by Dr. Besner.

81. Xia G, Martin A, Besner G: HB-EGF Down-Regulates Expression of Adhesion Molecules and Infiltration of Inflammatory Cells after Intestinal Ischemia/Reperfusion (I/R) Injury. Thirty-third Annual Meeting of the American Pediatric Surgical Association, Phoenix, AZ, May 22, 2002. Read by Dr. Xia.

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82. Besner G: HB-EGF and Intestinal Cytoprotection. Wound Healing, Oxygen & Emerging Therapeutics. International Conference on Oxygen Sensing, Oxidant Signaling, Oxygen Therapeutics, Gene Therapy, Angiogenesis and Clinical Research. Columbus, OH, September 15, 2002. Read by Dr. Besner.

83. Mehta V and Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Suppresses Nitric Oxide Production by Inhibiting the NF-kappa Signaling Pathway. Wound Healing, Oxygen & Emerging Therapeutics. International Conference on Oxygen Sensing, Oxidant Signaling, Oxygen Therapeutics, Gene Therapy, Angiogenesis and Clinical Research. Columbus, OH, September 15, 2002. Presented by Dr. Mehta.

84. Mehta V, Zimmerer J, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Suppresses NF-kB Activation and Decreases Nitric Oxide Production. 2003 Pediatric Academic Societies’ Meeting, Seattle, WA, May, 2003. Presented by Dr. Mehta.

85. Martin A, Luquette M, Besner G: HB-EGF Prophylactic and Salvage Therapy for Intestinal Ischemia/Reperfusion Injury. Thirty-fourth Annual Meeting of the American Pediatric Surgical Association, Ft. Lauderdale, FL, May, 2003. Read by Dr. Martin.

86. Besner G: The Surgical Separation of Conjoined Twins. The James E. Allan Memorial Lecture. Children’s Hospital, Buffalo, NY, June 14, 2003. Read by Dr. Besner.

87. Besner G: The Use of Growth Factors in Protection Against Intestinal Ischemia/Reperfusion Injury. American Academy of Pediatrics 2003 National Conference and Exhibition, New Orleans, LA, October, 2003. Read by Dr. Besner.

88. Corpron C, Martin A, Roberts G, Besner G: The Pediatric Burn Unit: A Profit Center. The American Academy of Pediatrics 2003 National Conference and Exhibition, New Orleans, LA, November 2, 2003. Read by Dr. Corpron.

89. Harding PA, Provenzano AP, James PF, Besner GE: Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) Misexpression in Transgenic Mice. Forty-third Annual Meeting of the American Society for Cell Biology, San Francisco, December, 2003. Presented by Dr. Harding.

90. Mehta V and Besner G: HB-EGF-Dependent Activation of PI-3-kinase Inhibits Cytokine-Induced NF-kappa B Activation in Human Intestinal Epithelial Cells. Keystone Symposium on NF-kappaB: Biology and Pathology. Snowbird, Utah, January 13, 2004. Presented by Dr. Mehta.

91. El-Assal O, Besner G: HB-EGF Improves Gut Permeability and Intestinal Restitution During the Early Phases After Intestinal Ischemia/Reperfusion. 65th Annual Meeting of the Society of University Surgeons, St. Louis, Missouri, February 13, 2004. Read by Dr. El-Assal.

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92. Corpron C, Roberts G, Teich S, Besner G: The Financial Impact of Pediatric Burn Care on the Hospital. 36th Annual Meeting of the American Burn Association, Vancouver, Canada, March 26, 2004. Read by Dr. Corpron.

93. Mehta V and Besner G: HB-EGF Mediated Inhibition of NF-kB Activation and Nitric Oxide Production in Intestinal Epithelial Cells is Mediated by the PI-3 Kinase Signaling Pathway. 2004 Pediatric Academic Societies’ Meeting, San Francisco, California, May 1, 2004. Presented by Dr. Mehta.

94. El-Assal O, Besner G: Endogenous HB-EGF is Involved in Intrinsic Restitution: Recombinant HB-EGF Enhances Intestinal Restitution in a PI3K/Akt and MEK/Erk 1/2 Dependent Fashion. 66th Annual Meeting of the Society of University Surgeons, Nashville, Tennessee, February 11, 2005. Read by Dr. El-Assal.

95. Besner G: The Role of Heparin-Binding EGF-Like Growth Factor (HB-EGF} in Protection of the Intestines from Injury. Invited Speaker, Research Seminar Series, Children’s National Medical Center, Washington, DC, April 8, 2005. Read by Dr. Besner.

96. Besner G: The Role of Heparin-Binding EGF-Like Growth Factor (HB-EGF} in Protection of the Intestines from Injury. Third International Symposium on Necrotizing Enterocolitis, Columbus, Ohio, April 16, 2005. Read by Dr. Besner.

97. Feng J, El-Assal O, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Decreases Necrotizing Enterocolitis in Neonatal Rats. Third International Symposium on Necrotizing Enterocolitis, Columbus, Ohio, April 16, 2005. Presented by Dr. Feng.

98. El-Assal O, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Promotes Intestinal Restitution. Third International Symposium on Necrotizing Enterocolitis, Columbus, Ohio, April 16, 2005. Presented by Dr. El-Assal.

99. Feng J, El-Assal O, Besner G: HB-EGF Decreases Necrotizing Enterocolitis in Neonatal Rats. 36th Annual Meeting of the American Pediatric Surgical Society, Phoeniz, AZ, May 30, 2005. Read by Dr. Feng.

100. Punati J, Abdessalam S, Besner G, Erdman S: Gastric Outlet Obstruction in a Patient with Ataxia Telangiectasia (AT). North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, October 2005. Presented by Dr. Punati.

101. Feng J, El-Assal O, Besner G: HB-EGF Reduces Intestinal Apoptosis in Neonatal Rats with Necrotizing Enterocolitis. The American Academy of Pediatrics 2005 National Conference and Exhibition, Washington, DC, October, 2005. Read by Dr. Feng.

102. Mehta V and Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Promotes Endothelial Cell Wound Healing and Angiogenesis via Activation of the PI3-Likase Pathway. Miami Nature Biotechnology Winter Symposium, University of Miami Miller School of Medicine, Miami, Florida, February 5, 2006. Presented by Dr. Mehta.

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103. El-Assal O, Besner G: HB-EGF Induces Focal Adhesion Kinase via ErbB-1/Src Activation in Non-Transformed Rat Intestinal Epithelial (RIE-1) Cells. 67th Annual Meeting of the Society of University Surgeons, San Diego, California, February 11, 2006. Read by Dr. El-Assal.

104. Rocourt D, Mehta V, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Systemic Pro-Inflammatory Cytokine Production after Intestinal Ischemia-Reperfusion Injury. 67th Annual Meeting of the Society of University Surgeons, San Diego, California, February 11, 2006. Read by Dr. Rocourt.

105. Paddock H, Fabia R, Giles S, Hayes J, Lowell W, Besner G: A Silver Impregnated Antimicrobial Dressing Reduces Hospital Length of Stay for Pediatric Burn Patients. 38th

Annual Meeting of the American Burn Association, April 4, 2006, Las Vegas, NV. Presented by Dr. Paddock.

106. Mehta V and Besner G: Activation of the PI3-Kinase Pathway Mediates Heparin-Binding EGF-Like Growth Factor (HB-EGF)–Induced Endothelial Cell Wound Healing and Angiogenesis. 2006 Pediatric Academic Societies’ Meeting, San Francisco, California, May, 2006. Presented by Dr. Mehta.

107. Rocourt D, Mehta V, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Pro-Inflammatory Cytokine Expression in the Intestine after Intestinal Ischemia/Reperfusion Injury. 2006 Pediatric Academic Societies’ Meeting, San Francisco, California, May, 2006. Read by Dr. Rocourt.

108. Feng J and Besner G: HB-EGF Promotes Enterocyte Proliferation and Migration in Neonatal Rats with Necrotizing Enterocolitis. 37th Annual Meeting of the American Pediatric Surgical Association, May 21, 2006, Hilton Head, SC. Presented by Dr Besner.

109. Paddock H, Fabia R, Giles S, Hayes J, Adams D, Besner G: A Silver Impregnated Antimicrobial Dressing Reduces Hospital Cost in Pediatric Burn Patients. 37th Annual Meeting of the American Pediatric Surgical Association, May 21, 2006, Hilton Head, SC. Presented by Dr. Paddock.

110. Rocourt D, Mehta V, Besner G: HB-EGF Decreases Neutrophil-Endothelial Cell Adhesion after Anoxia/Reoxygenation Injury. 37th Annual Meeting of the American Pediatric Surgical Association, May 21, 2006, Hilton Head, SC. Presented by Dr. Rocourt.

111. Besner G: HB-EGF Therapy for NEC in Rodent Models Now and in Humans by 2007. National Institutes of Health Digestive Diseases Interagency Coordinating Committee Workshop on New Therapies and Preventive Approaches for Necrotizing Enterocolitis, Invited Speaker, NIH, Bethesda, MD, July 11, 2006. Read by Dr. Besner.

112. El-Assal O and Besner G: HB-EGF Null Mice Have Increased Intestinal Injury and Mortality after Intestinal Ischemia/Reperfusion Injury. 2006 National Conference and

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Exhibition of the American Academy of Pediatrics, October 8, 2006, Atlanta, GA. Read by Dr. El-Assal.

113. Besner G: Heparin Binding EGF-Like Growth Factor (HB-EGF) Therapy for Necrotizing Enterocolitis. Causes and Consequences of Prematurity Symposium, Columbus Children’s Hospital, Columbus, Ohio, October 20, 2006. Read by Dr. Besner.

114. Besner G: HB-EGF and Protection of the Intestines from Injury. Invited Speaker, Trillium Therapeutics, Inv, Toronto, Ontario, October 20, 2006. Read by Dr. Besner.

115. Besner G: HB-EGF: Proposed Clinical Trial. Invited Speaker, Trillium Therapeutics, Inc, Toronto, Ontario, October 20, 2006. Read by Dr. Besner.

116. El-Assal O, Radulescu A, Besner G: HB-EGF Protects against Intestinal Damage and Enhances Restitution in Rats Subjected to Hemorrhagic Shock and Resuscitation. 2nd

Annual Academic Surgical Congress, 68th Annual Meeting of the Society of University Surgeons, Phoenix, AZ, February 8, 2007. Read by Dr. El-Assal.

117. Shiels, WE II, Kenney BD, Caniano DA, Besner GE: Definitive Percutaneous Treatment of Lymphatic Malformations of the Trunk and Extremities. 38th Annual Meeting of the American Pediatric Surgical Society, Orlando, FL, May, 2007. Read by Dr. Shiels.

118. El-Assal O, Besner G: HB-EGF Knockout Mice have Delayed Angiogenesis after Intestinal Ischemia/Reperfusion Injury. 38th Annual Meeting of the American Pediatric Surgical Society, Orlando, FL, May, 2007. Presented by Dr. El-Assal.

119. El-Assal O, Besner G: HB-EGF Increases Intestinal Microvascular Blood Flow In Rats Subjected to Ischemia/Reperfusion Injury. Pediatric Academic Societies’ Meeting, Toronto, Canada, May, 2007. Presented by Dr. El-Assal.

120. Paddock H, El-Assal O, Besner G: HB-EGF Knockout Mice have Increased Intestinal Permeability after Intestinal Ischemia/Reperfusion Injury. Pediatric Academic Societies’ Meeting, Toronto, Canada, May, 2007. Presented by Dr. Paddock.

121. Mehta V, Besner G: HB-EGF Promotes P38MAPK-Dependent Endothelial Cell Migration and Angiogenesis without Stimulating Proliferation. Pediatric Academic Societies’ Meeting, Toronto, Canada, May, 2007. Read by Dr. Mehta.

122. El-Assal O, Besner G: HB-EGF Knockout Mice have Decreased Angiogensis. 2007 National Conference and Exhibition of the American Academy of Pediatrics, San Francisco, CA, October, 2007. Read by Dr. El-Assal.

123. Zorko N, Radulescu A, Besner G: Production of a Murine Model of Necrotizing Enterocolitis. American Medical Association Medical Student Section Research Poster Symposium, Honolulu, HI, Nov 2007. Presented by N. Zorko.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.124. Mehta V and Besner G: HB-EGF Promotes eNOS Dependent Angiogenesis in

Endothelial Cells. Keystone Symposium, Keystone, CO, Jan 2008. Presented by Dr. Mehta.

125. Zhou Y and Besner G: Heparin Binding EGF-Like Growth Factor is a Potent Vasodilator of Terminal Mesenteric Arterioles. 3rd Annual Academic Surgical Congress, 69th Annual Meeting of the Society of University Surgeons, Huntington Beach, California, February 13, 2008. Read by Dr. Zhou.

126. Paddock H and Besner G: Expression of EGF Receptors in Healthy and NEC Afflicted Intestine. 69th Annual Meeting of the Society of University Surgeons, Huntington Beach, California, February 13, 2008. Read by Dr. Paddock.

128. Besner G: HB-EGF Therapy for Neonatal Necrotizing Enterocolitis – From Bench to Bedside. Toulukian Visiting Professorship, Yale Children’s Hospital, New Haven, CT, May 6, 2008. Read by Dr. Besner.

129. Besner G: The Surgical Separation of Conjoined Twins, Pediatric Surgery Grand Rounds, Yale Children’s Hospital, New Haven, CT, May 6, 2008. Read by Dr. Besner.

130. Zhou Y and Besner G: Heparin Binding EGF-Like Growth Factor Dilates Terminal Mesenteric Arterioles via Upregulation of ETB Receptors. 39th Annual Meeting of the American Pediatric Surgical Association, Phoenix, AZ, May 31, 2008. Read by Dr. Zhou.

131. Radulescu A, Yu X, Zorko N, Besner G: Pre-Clinical Studies of HB-EGF in Protection of the Intestines from Necrotizing Enterocolitis. 2008 National Conference and Exhibition of the American Academy of Pediatrics, Boston, MA, October 11, 2008. Read by Dr. Radulescu.

132. Radulescu A, Yu X, Chen Y, Besner G: HB-EGF Knockout Mice Have Increased Susceptibility to Necrotizing Enterocolitis. Owen H. Wangensteen Surgical Forum, 94th

Annual Congress of the American College of Surgeons, San Francisco, CA, October 15, 2008. Read by Dr. Radulescu.

133. Yu X, Radulescu A, Besner G: HB-EGF Therapy Increases Villous Microcirculatory Blood

Flow in Rat Pups with Experimental Necrotizing Enterocolitis. Owen H. Wangensteen Surgical Forum, 94th Annual Congress of the American College of Surgeons, San Francisco, CA, October 15, 2008. Read by Dr. Yu.

134. Orvets N, Radulescu A, Khalfoun S, Zorko N, Zhang H-Y, Besner G: HB-EGF Knockout Mice Exposed to Experimental Necrotizing Enterocolitis have Increased Intestinal Permeability. American Medical Association Medical Student Section Research Poster Symposium, Orlando, FL, Nov 7, 2008. Presented by N. Orvets.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.135. Hall M, Nateri J, Froner J, Besner G, Raffel C: Innate Immune Function and Nosocomial

Sepsis after Pediatric Critical Injury, Society of Critical Care Medicine Annual Congress, Jan 31, 2009, Nashville, TN. Presented by Dr. Hall.

136. Radulescu A, Yu X, Zorko N, Orvets N, Khalfoun S, Besner G: Prophylactic Therapy for Necrotizing Enterocolitis Using Heparin-Binding EGF-Like Growth Factor. 4Th Annual Academic Surgical Congress, 70th Annual Meeting of the Society of University Surgeons, Sanibel Island, Florida, Feb 5, 2009. Read by Dr. Radulescu.

137. Zhang H-Y, Radulescu A, Besner G: HB-EGF is Essential for Preservation of Gut Barrier Function after Hemorrhagic Shock and Resuscitation in Mice. 4Th Annual Academic Surgical Congress, 70th Annual Meeting of the Society of University Surgeons, Sanibel Island, Florida, Feb 5, 2009. Read by Dr. Zhang.

138. Rocourt D, Kenney B, Hall M, Fabia R, Groner J, Besner G: Respiratory Failure after Pediatric Scald Injury. 41st Annual Meeting of the American Burn Association, San Antonio, TX, March 2009. Read by Dr. Rocourt.

139. Burger J, Butz C, Fabia R, Besner G, Giles S, Canty H: The Application of Virtual Reality in a Multidisciplinary Medical Setting. Midwest Conference on Pediatric Psychology, Kansas City, MO, April 2, 2009. Read by Dr. Burger.

140. Besner G: The Systemic Inflammatory Response Syndrome in Trauma and Burns. The Ohio Annual Pediatric Trauma Symposium, Columbus, Ohio, April 17, 2009. Read by Dr. Besner.

141. Yu X, Radulescu A, Besner G: HB-EGF Preserves Villous Microvasculature and Structural Architecture in Rat Pups with Experimental Necrotizing Enterocolitis. American Pediatric Surgical Association, Las Croabas, Puerto Rico, May 27, 2009. Read by Dr. Yu.

142. Giles S, Besner G, Lowell W, Xiang H, Haley K. Attention Deficit Hyperactivity Disorder Increases the Prevalence and Severity of Burn Injuries in Children. Great Lakes Burn Group, Boston, MA, September 2009. Read by S. Giles.

143. Zhou Y, Radulescu A, Chen Y, Besner G: Deletion of the Heparin-Binding EGF-Like Growth Factor Gene in Mice Impairs Intestinal Transit. American College of Surgeons 2009 Congress, Chicago, IL, October 11, 2009. Read by Dr. Zhou.

144. Zhang H-Y, Radulescu A, Chen Y, Besner G: Heparin-Binding EGF-like Growth Factor (HB-EGF) Improves Intestinal Microcirculation after Hemorrhagic Shock and Resuscitation in Mice. American College of Surgeons 2009 Congress, Chicago, IL, October 11, 2009. Read by Dr. Zhang.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.145. Askegard-Giesmann J, Besner G, Fabia R, Caniano D, Preston T, Kenney B:

Extracorporeal Membrane Oxygenation (ECMO) as a Life-Saving Modality in the Treatment of Pediatric Patients with Burns and Respiratory Failure. American Academy of Pediatrics, 2009 National Conference and Exhibition, Washington, DC, October 16, 2009. Read by Dr. Askegard-Giesmann.

146. Chen C-L, Yu Xiaoyi, Radulescu A, Otabor I, Besner G: HB-EGF Protects Intestinal Stem Cells and Epithelial Cell Lineages from Necrotizing Enterocolitis. American Academy of Pediatrics, 2009 National Conference and Exhibition, Washington, DC, October 16, 2009. Read by Dr. Chen.

147. Otabor I, Besner G: HB-EGF Protects the Lungs from Remote Organ Injury After Intestinal Ischemia/Reperfusion. 5th Annual Academic Surgical Congress, 71st Annual Meeting of the Society of University Surgeons, San Antonio, TX, February 2, 2010. Association of Academic Surgery Plenary Session Oral Presentation. Read by Dr. Otabor.

148. Radulescu A, Zhang H-Y, Chen C-L, Chen Y, Zhou Y, Yu X, Otabor I, Olson J, Besner G: Expression Levels of Heparin-Binding EGF-Like Growth Factor Affect Intestinal Anastomotic Wound Healing. 5th Annual Academic Surgical Congress, 71st Annual Meeting of the Society of University Surgeons, San Antonio, TX, February 2, 2010. Read by Dr. Radulescu.

149. Giles S, Besner G, Lowell W, Xiang H, Haley K. Attention Deficit Hyperactivity Disorder Increases the Prevalence and Severity of Burn Injuries in Children. 42nd Annual Meeting of the American Burn Association, Boston, MA, March 2010. Read by S. Giles.

150. Zhou Y, Otabor I, Wetzl A, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Promotes Enteric Neural Crest Cell Migration. American Pediatric Surgical Association, Orlando, FL, May 27, 2010. Read by Dr. Zhou.

151. Besner G: Big News for Small Intestines. Circle of Care North American Leadership Conference, Atlanta, Georgia, May 13, 2010. Read by Dr. Besner.

152. Besner G: HB-EGF as a Novel Therapeutic Strategy for NEC. International NEC Webcast, hosted by Rainbow Babies Hospital and Nationwide Children’s Hospital, June 17, 2010.

153. Besner G: HB-EGF: From Bench to Bedside, Donna A. Caniano Symposium, Columbus, Ohio, August 28, 2010. Read by Dr. Besner.

154. Huang G, Besner G, Brigstock D: HB-EGF Gene Knockout Exacerbates Liver Fibrosis in Mice. 15th Annual International Symposium on Cells of the Hepatic Sinusoid, Pasadena, CA, August 2010. Read by Dr. Huang.Winner – Trainee Travel Award Competition

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Curriculum VitaeGAIL ELLEN BESNER, M.D.155. Chen C-L, Radulescu A, James I, Zhang H-Y, El-Assal O, Gunn J, Besner G: HB-EGF

Promotes α-Defensin Secretion from Intestinal Paneth Cells. American Academy of Pediatrics, 2010 National Conference and Exhibition, San Francisco, CA, October 2, 2010. Read by Dr. Chen.

156. Radulescu A, Zhang H-Y, Yu X, Olson J, Darbyshire A, Chen Y, Besner G: HB-EGF Overexpression in Transgenic Mice Increases Resistance to Necrotizing Enterocolitis. American College of Surgeons Surgical Forum, San Francisco, CA, October 5, 2010. Read by Dr. Radulescu.

157. Huang G, Besner G, Brigstock D: HB-EGF Attenuates Experimental Liver Fibrosis and Reduces Hepatic Stellate Cell Activation. Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Boston, MA, October 2010. Read by Dr. Huang.

158. Odar C, Brown Kirschman K, Pelley T, Persinger A, Butz C, Besner G, Fabia R: Symptoms of Post-traumatic Stress in Young Pediatric Burn Patients and their Parents, Kansas Conference in Clinical Child and Adolescent Psychology, Kansas City, MO, October 7, 2010. Presented by Dr. Odar.

159. Chen C-L, James IO, Yu X, Besner G: HB-EGF Protects Intestinal Stem Cells From Hypoxic Stress Via The EGFR/PI3K/MAPK Pathway, 6th Annual Academic Surgical Congress, Huntington Beach, CA, Feb 1, 2011. Association of Academic Surgery Plenary Session Oral Presentation. Read by Dr. Chen.

160. Odar C, Brown Kirschman K, Pelley T, Butz C, Besner G, Fabia R: Demographic and Injury Variables as Predictors of ChildPost-traumatic Stress Symptoms Following Burn Injury. National Conference in Pediatric Psychology, San Antonio, TX, April 14, 2011. Presented by Dr. Odar

161. VerLee S, Ackerman C, Butz C, Fabia R, Besner G, Giles, S: The Application of Virtual Reality to Reduce Pain and Distress. Society of Pediatric Psychology, San Antonio, TX, April 14, 2011. Presented by Dr. VerLee.

162. Pelley T, Brown-Kirschman K, Odar C, Butz C, Besner G, Fabia : The Development and Validation of the Psychosocial Adjustment to Burn Questionnaire for Children Age Five and Under. Society of Pediatric Psychology, San Antonio, TX, April 14, 2011. Presented by Dr. Pelley.

163. Radulescu A., Yang J., Chen C-L., Zhang H-Y., James I., Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF Improves Intestinal Barrier Function and Reduces Mortality in a Murine Model of Peritonitis. Ohio Chapter of the American College of Surgeons, Cincinnati, Ohio, May 6, 2011. Presented by Dr. Radulescu.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.163. Yang J, Radulescu A, Chen C-L, Zhang H-Y, James I, Besner G: Heparin-Binding EGF-

Like Growth Factor Improves Intestinal Barrier Function and Reduces Mortality in a Murine Model of Peritonitis. American Pediatric Surgical Association, Palm Desert, CA, May 22, 2011. Read by Dr. Yang.

164. Zhou Y, Markmann K, Besner G: Over-expression of HB-EGF Protects Intestinal Myenteric Plexus Neurons Subjected to Ischemia/Reperfusion Injury. American Pediatric Surgical Association, Palm Desert, CA, May 22, 2011. Read by Dr. Zhou.

165. Besner G, Yang J, Watkins D, Zhou Y, Chen C-L: HB-EGF: Heparin-binding EGF-like Growth Factor (HB-EGF) to Prevent Necrotizing Enterocolitis. 52nd Annual Meeting of the European Society for Pediatric Research, New Castle, England, October 14, 2011. Invited Speaker. Read by Dr. Besner.

166. Yang J, Chen C-L, Watkins D, Zhang H-Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) and Mesenchymal Stem Cells (MSC) Act Synergistically to Prevent Experimental Necrotizing Enterocolitis. American College of Surgeons, Surgical Forum, San Francisco, CA, Oct 23, 2011. Read by Dr. Yang.

167. Besner G: HB-EGF Therapy for Intestinal Injury - Bringing Research Results to the Bedside. Patricia C. Moynihan Women in Academic Surgery Lectureship, East Tennessee State University, November 4, 2011. Read by Dr. Besner.

168. Besner G: Strategies for Improving Outcome in Patients with Necrotizing Enterocolitis. American Academy of Pediatrics Perinatal Section's 79th Perinatal & Developmental Medicine Symposium, Marco Island, Florida, November 10-13, 2011. Read by Dr. Besner.

169. Besner G: HB-EGF Therapy for Necrotizing Enterocolitis. American Academy of Pediatrics Perinatal Section's 79th Perinatal & Developmental Medicine Symposium, Marco Island, Florida, November 10-13, 2011. Read by Dr. Besner.

170. Besner G: HB-EGF Therapy for Necrotizing Enterocolitis. Surgery Grand Rounds, American Family Children’s Hospital, University of Wisconsin, January, 2012. Read by Dr. Besner.

171. Lutmer J, Chen C-L, Velton M, Zhang H-Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Attenuates Acute Lung Injury Following Scald Burn in Mice. Society of Critical Care Medicine Congress, Houston, TX, Feb. 4, 2012. Presented by Dr. Lutmer.

172. Zhou Y, Yang J, Besner G: Enteric Neural Stem Cell Transplantation Restores Intestinal Motility in Rat Pups Subjected to Necrotizing Enterocolitis. 7 th Annual Academic Surgical Congress, Las Vegas, NV. Feb 14, 2012. Read by Dr. Zhou.

173. Watkins D, Chen C-L, Besner G: Heparin-binding EGF-Like Growth Factor (HB-EGF) Promotes Mesenchymal Stem Cell (MSC) Proliferation and Migration and Decreases

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MSC Apoptosis. 7th Annual Academic Surgical Congress, Las Vegas, NV. Feb 14, 2012. Read by Dr.Watkins.

174. Lutmer J, Chen C-L, Zhang H-Y, Velton M, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Attenuates Acute Lung Injury Following Scald Burn in Mice. American Burn Association, San Antonio, TX, April, 2012. Presented by Dr. Lutmer.

175. VerLee S, Butz C, Ackerman C, Burger J, Fabia R, Besner G: The Utility of Virtual Reality in Minimizing Procedural Distress with Pediatric Burn Patients. American Burn Association, San Antonio, TX, April, 2012. Presented by Dr. VerLee.

176. Watkins D, Zhou Y, Chen C-L, Darbyshire A, Besner G: Heparin-Binding EGF-Like Growth Factor Protects Mesenchymal Stem Cells. Annual Meeting of the Ohio Chapter of the American College of Surgeons, Toledo, OH, May 4, 2012. Presented by Dr. Watkins.

177. Yang J, Chen C-L, Watkins D, Zhang H-Y, Besner G: Mesenchymal Stem Cells (MSC) and Heparin-binding EGF-like Growth Factor (HB-EGF) Act Synergistically to Prevent Experimental Necrotizing Enterocolitis. American Pediatric Surgical Association, San Antonio, TX, May 22, 2012. Read by Dr. Yang.

178. Besner G: HB-EGF Therapy for NEC. American Pediatric Surgical Association, San Antonio, TX, May 22, 2012. Invited Speaker. Read by Dr. Besner.

179. Besner G: HB-EGF Therapy for Necrotizing Enterocolitis. Annual Meeting of Pediatrics, Acapulco, Mexico, August 16, 2012. Invited Speaker. Read by Dr. Besner.

180. Besner G: Surgical Management of Necrotizing Enterocolitis. Annual Meeting of Pediatrics, Acapulco, Mexico, August 17, 2012. Invited Speaker. Read by Dr. Besner.

181. Watkins D, Besner G: Synergistic Effects of HB-EGF and Mesenchymal Stem Cells in a Murine Model of Intestinal I/R Injury. Surgical Forum, American College of Surgeons, Chicago, IL, September 30, 2012. Read by Dr. Watkins.

182. Matthews M, Watkins D, Darbyshire A, Besner G: HB-EGF Protects the Intestines from Radiation Therapy-Induced Intestinal Injury. Surgical Forum, American College of Surgeons, Chicago, IL, September 30, 2012. Read by Dr. Matthews.

183. Besner G: Research in Etiology and Treatment for Necrotizing Enterocolitis. Necrotizing Enterocolits Symposium. Johns Hopkins University, Baltimore, MD. Invited Speaker. October 12, 2012. Read by Dr. Besner.

184. Watkins D, Zhang H-Y, Darbyshire A, Besner G: Synergistic Effects of HB-EGF and Mesenchymal Stem Cells in a Murine Model of Intestinal Ischemia-Reperfusion Injury.

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American Academy of Pediatrics, New Orleans, LA, October 20, 2012. Read by Dr. Watkins.

185. Matthews M, Watkins D, Darbyshire A, Carson W, Besner G: HB-EGF Protects the Intestines from Radiation Therapy-Induced Intesinal Injury. American Academy of Pediatrics, New Orleans, LA, October 20, 2012. Read by Dr. Matthews.Winner of Rosencrantz Resident Research Award for Best Basic Science Research

186. Zhou Y, Su Y, Yang J, Watkins D, Besner G: Heparin-Binding EGF-Like Growth Factor Promotes Enteric Neurogenesis Via the Preservation of Glial Integrity After Necrotizing Enterocolitis. Academic Surgical Congress, New Orleans, LA, February 5, 2013. Read by Dr. Zhou.

187. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Visiting Professor, Children’s Hospital of Philadelphia, Philadelphia, PA. Invited Speaker. February 28, 2013. Read by Dr. Besner.

188. Besner G: Research in the Etiology and Treatment of Necrotizing Enterocolitis. American Academy of Pediatrics District IX Section on Perinatal Pediatrics, California Association of Neonatologists Cool Topics in Neonatology Conference, Coronado, CA. Invited Speaker. March 2, 2013. Read by Dr. Besner.

189. Besner G, Watkins D, Zhou Y: Stem Cell Therapy for the Treatment of Necrotizing Enterocolitis. Center for Regenerative Medicine and Cell Based Therapies, Regenerative Medicine Wound Conference, Columbus, Ohio, March 14, 2013. Read by Dr. Besner.

190. Zhou Y, Yang J, Besner G: Neural Stem Cell Transplantation Reverses the Enteric Nervous System Injury that Occurs in Necrotizing Enterocolitis. Center for Regenerative Medicine and Cell Based Therapies, Regenerative Medicine Wound Conference, Columbus, Ohio, March 14, 2013. Presented by Dr. Zhou.

191. Watkins D, Zhou Y, Yang J, Matthews M, Darbyshire A, Besner G: Synergistic Effects of HB-EGF on Mesenchymal Stem Cells in Vitro and in Vivo. Center for Regenerative Medicine and Cell Based Therapies, Regenerative Medicine Wound Conference, Columbus, Ohio, March 14, 2013. Presented by Dr. Watkins.

192. Boomer L, Liu Y, Mahler N, Johnson J, Zak K, Besner G: Determination of Optimal Scaffold Material for the Production of Tissue Engineered Intestine. Center for Regenerative Medicine and Cell Based Therapies, Regenerative Medicine Wound Conference, Columbus, Ohio, March 14, 2013. Presented by Dr. Boomer.

193. Zhou, Besner G: Neonatal Necrotizing Enterocolitis is Associated with a Compromised Enteric Nervous System. American Pediatric Surgical Association, Marco Island, FL, May 2, 2013. Read by Dr. Zhou.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.194. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of

Necrotizing Enterocolitis. Ballantine Visiting Professor, Penn State Hershey Children’s Hospital, Hershey, PA. Invited Speaker. May 23, 2013. Read by Dr. Besner.

195. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. International Symposium of Pediatric Hepatobiliary Disease, Tongji Hospital, Wuhan, China. Invited Speaker. July 13, 2013. Read by Dr. Besner.

196. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Department of Pediatric Surgery, Sichuan Provincial People’s Hospital, Chengdu, China. Invited Speaker. July 18, 2013. Read by Dr. Besner.

197. Watkins D, Matthews M, Zhou Y, Besner G: HB-EGF Augments the Ability of Mesenchymal Stem Cells to Attenuate Intestinal Injury. American Academy of Pediatrics National Conference and Exhibition, Orlando, FL, October 26, 2013. Read by Dr. Watkins.

198. Boomer L, Copper J, Deans K, Minneci P, Leonhart K, Diefenbah K, Kenney B, Besner G: Does Delay in Appendectomy affect Surgical Site Infection in Children with Appendicitis? American Academy of Pediatrics National Conference and Exhibition, Orlando, FL, October 26, 2013. Read by Dr. Boomer.Winner of Rosencrantz Resident Research Award for Best Clinical Research

199. Besner G: Production of Tissue Engineered Intestine. Center for Regenerative Medicine and Cell Based Therapies, Second Annual Retreat, Perrysville, Ohio, July 26-27, 2013. Read by Dr. Besner.

200. Boomer L, Watkins D, O’Donovan J, Kenney B, Yates A, Besner G: An Unusual Case of Foreign Body Pulmonary Embolus: Case Report and Review of the Literature. Central Ohio Trauma Symposium, September 9, 2013. Read by Dr. Boomer.

201. Boomer L, Watkins D, O’Donovan J, Kenney B, Yates A, Besner G: An Unusual Case of Foreign Body Pulmonary Embolus: Case Report and Review of Penetrating Trauma at a Pediatric Trauma Center. The Ohio Committee on Trauma, ACS Trauma Paper Competition, Cleveland Medical Mart & Convention Center, Cleveland, Ohio, October 28, 2013. Read by Dr. Boomer.

202. Wei J, Zhou Y, Besner G: Heparin-Binding EGF-like Growth Factor and Enteric Neural Stem Cell Transplantation Act Synergistically to Prevent Experimental Necrotizing Enterocolitis. Academic Surgical Congress, San Diego, CA, February 4, 2014. Read by Dr. Wei.

203. Besner G: Novel Therapeutic Strategies for the Treatment of Necrotizing Enterocolitis. Center for Regenerative Medicine and Cell Based Therapies Conference, Columbus, Ohio, March 13, 2014. Read by Dr. Besner.

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204. Liu Y, Rager T, Painter P, Nelson T, Linutti J, Besner G: HB-EGF Incorporation into PGA Enhances the Formation of Tissue Engineered Intestine. Center for Regenerative Medicine and Cell Based Therapies Conference, Columbus, Ohio, March 13, 2014. Presented by Dr. Liu.

205. Wei J, Zhou Y, Besner G: HB-EGF and Neural Stem Cells Act Synergistically to Prevent Experimental NEC. Center for Regenerative Medicine and Cell Based Therapies Conference, Columbus, Ohio, March 13, 2014. Presented by Dr. Wei.

206. Zhou Y, Wei J, Besner, G: Neural Stem Cell-derived Exosomes Protect the Enteric Nervous System from Necrotizing Enterocolitis. Center for Regenerative Medicine and Cell Based Therapies Conference, Columbus, Ohio, March 13, 2014. Presented by Dr Zhou.

207. Besner G: A Pain in the NEC: Research Challenges and Opportunities. American Pediatric Surgical Association, Invited Speaker, Jay and Margie Grosfeld Lecture in Pediatric Surgery. Phoenix, AZ, May 29, 2014. Read by Dr. Besner.

208. Zhou Y, Besner G: Overexpression of HB-EGF Promotes Survival and Differentiation of Enteric Neural Stem Cells after Transplantation into Mouse Dysganglionic Colon. American Pediatric Surgical Association, Phoenix, AZ, May 29, 2014. Read by Dr. Zhou.

209. Besner G: Necrotizing Enterocolitis: Research Challenges and Opportunities. Visiting Professor Lecture Series, Rush University, Chicago, IL, June 18, 2014. Read by Dr. Besner.

210. Besner G: Improving the Production of Tissue Engineered Intestine. Center for Regenerative Medicine and Cell Based Therapies, Third Annual Retreat, Perrysville, Ohio, August 1-2, 2014. Read by Dr. Besner.

211. Liu Y, Rager T, Lannutti J, Johnson J, Painter P, Nelson T, Enmark J, Besner G: HB-EGF Incorporation into Polyglycolic Acid (PGA) Scaffolds Enhances the Formation of Tissue Engineered Intestine. American Academy of Pediatrics, October 10, 2014, San Diego, CA. Read by Dr. Liu.

212. Zhou Y, Wei J, Besner G: Neural Stem Cell-Derived Exosomes Protect the Intestines from Necrotizing Enterocolitis. American Academy of Pediatrics, October 10, 2014, San Diego, CA. Read by Dr. Zhou.

213. Nielson J, Shi J, Wheeler K, Groner J, Besner G. Kenney B: Characteristics of Penetrating Pediatric Trauma in the US: A National Trauma Database Analysis. American Academy of Pediatrics, October 10, 2014, San Diego, CA. Read by Dr. Nielson.

214. Raval M, Rust L, Thakkar R, Kurtovic K, Nwomeh B, Besner G, Kenney B: Development and Implementation of an Electronic Health Record Generated Surgical

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Handoff and Rounding Tool. American Academy of Pediatrics, October 10, 2014, San Diego, CA. Read by Dr. Raval. Winner of Rosencrantz Resident Research Award for Best Poster

215. Besner G: Necrotizing Enterocolitis: Research Challenges and Opportunities. William Gelfand Lecture, Phi Delta Epsilon Pre-Med Fraternity, University of Akron, Akron, OH, November 6, 2014. Read by Dr. Besner.

216. Besner G: Production of Tissue Engineered Intestine. 2014 Pediatric Colorectal and Pelvic Reconstruction Conference. November 13, 2014. Read by Dr. Besner.

217. Liu Y, Rager T, Painter P, Besner G: Enriched Intestinal Stem Cells Improve the Architecture of Tissue Engineered Intestine. Tissue Engineering and Regenerative Medicine International Society (TERMIS) Annual Conference and Exposition, Washington, DC, December 13, 2014. Presented by Dr. Liu.

218. Besner G: Gastrointestinal Tissue Engineering: Experimental Innovation to Clinical Applications. First Health Care, Career and Commerce (H3C) Pre-Conference, Delhi, India, January 11, 2015. Read by Dr. Besner.

219. Besner G: Improving the Production of Tissue Engineered Intestine. First Health Care, Career and Commerce (H3C) Conference, Mumbai, India, January 17, 2015. Read by Dr. Besner.

220. Zhou Y and Besner G: Profiling of Circulating Exosomal MicroRNAs in Neonatal Necrotizing Enterocolitis. 10th Annual Meeting of the Academic Surgical Congress, Las Vegas, NV, February 3, 2015. Read by Dr. Zhou.

221. Giles S, Kurtovic K, Groner J, Fabia R, Humphry R; Fabia R, Besner G, von Sadovszky V: The Evaluation of a Nursing Pain Assessment Tool Utilized during Burn Dressing Changes in a Pediatric Burn Center. American Burn Association. American Burn Association, Chicago, IL, April 22, 2015. Read by S. Giles.

222. Cromeens B, Brilli R, Kurtovic K, Nwomeh B, Kenney B, Besner G: Implementation of a Pediatric Surgical Quality Improvement (QI)-Directed M&M Conference. American Pediatric Surgical Association, Ft. Lauderdale, FL, May 2, 2015. Read by Dr. Cromeens.Winner of the M. Judah Folkman Award for Best Clinical Research Podium Presentation

223. Zhou Y and Besner G: Transplantation of Amniotic Fluid Derived Neural Stem Cells as a Potential Novel Therapy For Hirschsprung’s Disease. American Pediatric Surgical Association, Ft. Lauderdale, FL, April 30, 2015. Read by Dr. Zhou.

224. Liu Y, Rager T, Johnson J, Lannutti J, Enmark J, Nelson T, Besner G: Comparison of Tissue Engineered Intestine Produced from Non-woven Polyglycolic Acid, CollaTape

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Collagen, and Nanofiber Poly (Ɛ-caprolactone) Scaffolds. Society for Biomaterials, Charlotte, NC, April 16, 2015. Read by Dr. Liu.

225. Cromeens B, Brilli R, Kurtovic K, Kenney B, Nwomeh B, Besner G: Implementation Of A Pediatric Surgical Quality Improvement (QI)-Driven M&M Conference. Ohio Hospital Association 2015 Quality Summit, A Century of Health Care Innovation, Columbus, Ohio, June 10, 2015. Presented by Dr. Cromeens.

226. Wood RJ, Lane VA, Millar AJW, Levitt MA, Besner GE: Pygopagus Conjoined Twins: Case Presentation to discuss operative management of complex colorectal and anal sphincter challenges. 22nd International Meeting of the Colorectal Club, Milan, Italy, June 14, 2015. Read by Dr. Wood.

227. Cromeens B, Brilli R, Kurtovic K, Kenney B, Nwomeh B, Besner G: Findings From a Quality Improvement (QI)-Directed Pediatric Surgical M&M Conference One Year after Implementation. American College of Surgeons NSQIP Meeting, Chicago, IL, July 25, 2015. Read by Dr. Cromeens.Winner ACS NSQIP MED-RES Abstract Award

228. Boomer L, Cooper J, Anandalwar S, Fallon S, Ostlie D, Leys C, Rangel S, Mattei P, Sharp S, St. Peter S, Rodriguez R, Kenney B, Besner G, Deans MD K, Minneci P: Delaying appendectomy does not lead to higher rates of surgical site infections: A multi-institutional analysis of children with appendicitis. American College of Surgeons NSQIP Meeting, Chicago, IL, July 25, 2015. Read by Dr. Boomer.

229. Navarro J, Olson J, Mashburn-Warren L, Besner G, Goodman S: A novel probiotic formulation utilizing dextranomer microspheres reduces the incidence of necrotizing enterocolitis. 22nd Annual Midwest Microbial Pathogenesis Conference, Indianapolis, IN, August 28, 2015. Presented by Dr. Navarro.

230. Liu Y, Rager T, Cromeens B, Johnson J, Chakroff J, Besner G: Comparison of Different in vivo Incubation Sites for Production of Tissue Engineered Intestine. 4th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress Annual Conference and Exposition, Boston, MA, September 8, 2015. Presented by Dr. Liu.

231. Besner G: Saving Your NEC: Research Challenges and Opportunities. Duke Surgery Grand Rounds, Durham, NC, September 30, 2015. Read by Dr. Besner.

232. Olson J, Rager T, Navarro J, Mashburn-Warren L, Goodman S, Besner G: A Novel Approach to Probiotic Delivery for Neonatal Necrotizing Enterocolitis. American College of Surgeons Surgical Forum, Chicago, IL, October 4, 2015. Presented by Dr. Olson.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.233. Besner G: Building a Portfolio for Promotion. Pediatric Surgery Residents Conference,

American Academy of Pedatrics, Section on Surgery, Washington, DC, October 23, 2015. Read by Dr. Besner.

234. Olson J, Rager T, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Harvesting the Benefits of Biofilms: A Novel Probiotic Delivery Method for the Prevention of Necrotizing Enterocolitis. American Academy of Pediatrics, Section on Surgery, Washington, DC, October 24, 2015. Read by Dr. Olson.

235. Rager T, Olson J, Besner G: Exosomes Secreted from Bone Marrow-Derived Mesenchymal Stem Cells Protect Intestines from Experimental NEC. American Academy of Pediatrics, Section on Surgery, Washington, DC, October 24, 2015. Read by Dr. Rager.Winner of Rosencrantz Award for Best Basic Science Research Presentation

236. Besner G: Separation of Conjoined Twins Acen and Apio. Second Annual International Colorectal Course, Columbus, Ohio, November 6, 2015. Read by Dr. Besner.

237. Johnson S, Wheeler K, Shi J, Fabia R, Thakkar R, Groner, J, Besner G, Xiang H: Factors Associated with Inter-facility Transfer of Pediatric Burn Patients in U.S. Emergency Departments (EDs). Pediatric Trauma Society. Scottsdale, AZ, November 6, 2015. Read by Dr. Johnson.

238. Cromeens B, Liu Y, Stathopoulos J, Johnson J, Besner G: Ex Vivo Enteroid Cultures Can Be Used To Produce Tissue Engineered Intestine. Academic Surgical Congress, February 2, 2016, Jacksonville, FL. Read by Dr. Cromeens.

239. McKinney J, Brown J, Henry C, Cromeens B. Besner G, Islam M: Pygopagus Conjoined Twins: An Intraoperative Monitoring Schema. American Clinical Neurophysiology Society (ACNS) Annual Meeting, Orlando, FL, Feb 12, 2016. Presented by Dr. McKinney.

240. Shen S, Zhao Z, Wang H, Yilin H, Erbao D, Liu B, Liu, W, Cromeens B, Besner G, Ray W, Hoehne B, Adler B, Xu R: A Three-Dimensionally Printed Phantom for Surgical Planning in Conjoined Twin Separation Surgery. Photonics West, Feb 13, 2016, San Francisco, CA. Read by Dr. Shen.

241. Besner G: Can Biology Guide NICU Practice to Prevent and Recover from NEC? Angus McBryde Symposium: 13th Annual Dialogues in Neonatal-Perinatal Medicine, Duke University, Durham, NC, March 7, 2016. Read by Dr. Besner.

242. Besner G: Intestinal Development from the Surgeon’s Perspective. Angus McBryde Symposium: 13th Annual Dialogues in Neonatal-Perinatal Medicine, Duke University, Durham, NC, March 7, 2016. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.243. Besner G: Harvesting the Power of the Intestinal Stem Cell in the Production of Tissue

Engineered Intestine. Center for Regenerative Medicine and Cell Based Therapies T2C Conference, Columbus, Ohio, March 17, 2016. Read by Dr. Besner.

244. Liu Y, Rager T, Cromeens B, Johnson J, Chakroff J, Besner G: In Vivo Incubation Site Affects the Production of Tissue Engineered Intestine. Center for Regenerative Medicine and Cell Based Therapies T2C Conference, Columbus, Ohio, March 17, 2016. Presented by Dr. Liu.

245. Cromeens B, Liu Y, Stathopoulos J, Wang Y, Johnson J, Besner G: The Producion of Tissue Engineered Intestine using Expanded Enteroids. Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, March 17, 2016. Presented by Dr. Cromeens. Bronze Prize Winner – Resident’s Poster Competition (BC)

246. McCulloh C, Olson J, Zhou Y, Wang Y, Besner G: Reducing the Incodence and Severity of Necrotizing Enterocolitis Using Stem Cells: A Quantitative Analysis. Center for Regenerative Medicine and Cell Based Therapies T2C Conference, Columbus, Ohio, March 17, 2016. Presented by Dr. McCulloh.

247. Olson J, Rager T, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Probiotic Biofilms Enhance Protection of Intestines from Necrotizing Enterocolitis. Center for Regenerative Medicine and Cell Based Therapies T2C Conference, Columbus, Ohio, March 17, 2016. Presented by Dr. Olson.

248. Zhou Y, Besner G: Exosomes Secreted by Neural Stem Cells Protect the Intestines from Ischemia-Reperfusion Injury. Center for Regenerative Medicine and Cell Based Therapies T2C Conference, Columbus, Ohio, March 17, 2016. Presented by Dr. Zhou.

249. Cromeens B, Liu Y, Stathopoulos J, Huibregtse N, Besner G: The Effect of Enteroid Seeding Density on the Production of Tissue Engineered Intestine (TEI). American Pediatric Surgical Association, May 14, 2016, San Diego, CA. Read by Dr. Cromeens.

250. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Huibregtse N, Goodman S, Besner G: Enhancing the Ability of Lactobacillus reuteri to Protect the Intestines from Experimental Necrotizing Enterocolitis. American Pediatric Surgical Assocation, May 14, 2016, San Diego, CA. Read by Dr. Olson.

251. Cromeens B, Liscandro R, Brilli R, Askegard-Guismann J, Kenney B, Besner G: Identifying Adverse Events In Pediatric Surgery: Comparing Morbidity & Mortality Conference To The National Surgical Quality Improvement Program – Pediatric (NSQIP-P) System. American College of Surgeons NSQIP Meeting, July 16, 2016, San Diego, CA. Read by Dr. Cromeens.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.252. Gartner S, Olson, J, McCulloh C, Besner G: Utilizing the Benefits of Biofilms:

Prevention of Necrotizing Enterocolitis using a Novel Probiotic Delivery Syatem. Pediatric Medical Student Research Forum, Orlando, FL, September 3, 2016. Read by S. Gartner.Third Place Prize Winner – Student Research Competition (SG)

253. Varaljay V, Olson J, Navarro J, Mashburn-Warren L, Besner G, Bailey M, Goodman S: A Tunable, Single Dose Formulation of Lactobacillus Reuteri That Effectively Prevents Necrotizing Enterocolitis. American Society of Micobiology Beneficial Microbes Conference, Seattle, WA, September 9, 2016. Presented by Dr. Varaljay.

254. Besner G: Novel Methods of Stem Cell Therapy and Probiotic Administration for NEC. SIGNEC U.K. (Special Interest Group NEC U.K.), September 26, 2016, London, England. Read by Dr. Besner.

255. Besner G: Introduction to the Necrotizing Enterocolitis Surgery Trial (NEST). SIGNEC U.K. (Special Interest Group NEC U.K.), September 27, 2016, London, England. Read by Dr. Besner.

256. Manda D, Zhou Y, Besner G: Neural Stem Cell-derived Exosome Targeting of Injured Intestinal Neurons is Integrin Dependent. Northeastern Ohio Medical University Chapter of the American Medical Women's Association's Summer Symopsium, Rootstown, OH, October 12, 2016. Presented by D. Manda.

257. Liu Y, Cromeens B, Wang Y, Johnson J, Chakroff J, Besner G: In Vivo Vascularization of Tissue Engineered Intestine. American Academy of Pediatrics, Section on Surgery, Oct 22, 2016, San Francisco, CA. Read by Dr. Liu.

258. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Sucrose Promotes Lactobacillus reuteri Biofilm Production and Enhances Protection of the Intestines from Experimental Necrotizing Enterocolitis. American Academy of Pediatrics, Section on Surgery, Oct 22, 2016, San Francisco, CA. Read by Dr. Olson.

259. McCulloh C, Olson J, Zhou Y, Wang Y, Besner G: Stem Cells and Necrotizing Enterocolitis: A Direct Comparison of the Efficacy of Multiple Types of Stem Cells. American Academy of Pediatrics, Section on Surgery, Oct 22, 2016, San Francisco, CA. Read by Dr. McCulloh.Winner of Rosencrantz Award for Best Basic Science Research Presentation

260. Manda D, Zhou Y, Besner G: Neural Stem Cell-derived Exosome Targeting of Injured Intestinal Neurons is Integrin Dependent. Association of Indian Physician of Northern Ohio Annual Research Symposium, Cleveland, OH, October 22, 2016. Presented by D. Manda.

261. Varaljay V, Olson J, Navarro J, Mashburn-Warren L, Besner G, Bailey M, Goodman S:

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A protective Lactobacillus reuteri formulation that enhances its beneficial properties and prevents necrotizing enterocolitis (NEC) in the intestines with a single persistent dose. Human Microbiome Consortium Congress, Nov 9, 2016, Houston, TX. Presented by Dr. Varaljay.

262. Liu Y, Cromeens B, Wang Y, Johnson J, Chakroff J, Besner G: Comparison of Different Ages of Cell Donors for the Production of Tissue Engineerd Intestine (TEI). Tissue Engineering and Regenerative Medicine International Meeting, San Diego, CA, Dec 11, 2016. Presented by Dr. Liu.

263. McCulloh C, Olson J, Wang Y, Vu J, Gartner S, Besner G: Evaluating the Efficacy of Different Types of Stem Cells in Preserving Gut Barrier Function in NEC. Academic Surgical Congress, Las Vegas, NV, Feb 7, 2017. Read by Dr. McCulloh.Finalist for the Best Resident Research Presentation.

264. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Enriched Probiotic Biofilms: Preservation of Gut Barrier Function in Necrotizing Enterocolitis. Academic Surgical Congress, Las Vegas, NV, Feb 7, 2017. Read by Dr. Olson.

265. Cromeens B, Wang Y, Liu Y, Johnson J, Besner G: Critical Intestinal Cells Originate from the Host in Enteroid-Derived Tissue Enginered Intestine. Academic Surgical Congress, Las Vegas, NV, Feb 7, 2017. Read by Dr. Cromeens.

266. Besner G: Scaling Up the Production of Tissue Engineered Intestine. Center for Regenerative Medicine and Cell Based Therapies T2C Conference, Columbus, Ohio, March 9, 2017. Read by Dr. Besner.

266. Besner G: Stem Cell-Derived Exosomes in Protection of the Intestines from Necrotizing Enterocolitis. NEC Symposium: A Transdisciplinary Approach to Improved NEC Outcomes, Sacramento CA, April 6, 2017. Read by Dr. Besner.

267. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Enriched Probiotic Biofilms: Preservation of Gut Barrier Function in Necrotizing Enterocolitis. NEC Symposium: A Transdisciplinary Approach to Improved NEC Outcomes, Sacramento CA, April 6, 2017. Presented by Dr.Olson. (pending)

268. Olson J, Deming L, King D, Rager T, Gartner S, Huibregtse N, Moss L, Besner G: Single Visit Surgery for Pediatric Ambulatory Surgical Procedures: A Satisfaction and Cost Analysis. American Pediatric Surgical Association Meeting, Hollywood, FL, May 4, 2017 (pending).

269. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Goodman S, Besner G: GtfW: An Inconspicouos Enzyme that Provides Conspicuous Protection Against Necrotizing

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Enterocolitis. American Pediatric Surgical Association Meeting, Hollywood, FL, May 4, 2017 (pending).

270. Aldrink J, Sales, Besner G, Hewitt G: Using Quality Improvement Methodology to Improve Ovarian Salvage for Benign Adnexal Lesions. American Pediatric Surgical Association Meeting, Hollywood, FL, May 4, 2017 (pending).

271. McCulloh C, Olson J, Wang Y, Zhou Y, Besner G: Stem Cell Engraftment in the Prophylactic Treatment of Experimental Necrotizing Enterocolitis. American Pediatric Surgical Association Meeting, Hollywood, FL, May 4, 2017 (pending).

272. Nordin A, Sales S, Besner G, Levitt M, Wood R, Kenney B: Effective Methods to Decrease Surgical Site Infection in Pediatric Gastrointestinal Surgery. American Pediatric Surgical Association Meeting, Hollywood, FL, May 4, 2017 (pending).

PRESENTATIONS

Regional and Local

1. Besner G: A Novel Macrophage-Secreted Growth Factor. Surgical Research Conference, The Brigham & Women's Hospital, Boston, Massachusetts, March 1989. Read by Dr. Besner.

2. Besner G: Macrophage-Secreted Growth Factors. Surgical Grand Rounds, The Children's Hospital, Boston, Massachusetts, March 1989. Read by Dr. Besner.

3. Besner G: Macrophage-Secreted Growth Factors. Surgical Grand Rounds, The West Roxbury VA Hospital, Boston, Massachusetts, May 1989. Read by Dr. Besner.

4. Besner G: Identification of Novel Macrophage Secreted Growth Factors. Surgical Grand Rounds, Roswell Park Cancer Institute, Buffalo, New York, November 1990. Read by Dr. Besner.

5. Besner G: Macrophage Secretion of Novel Growth Factors. Surgical Grand Rounds, James G. Arthur Cancer Hospital and Research Institute, Ohio State University, Columbus, Ohio, January 1991. Read by Dr. Besner.

6. Whelton D, Crissman-Combs M, Brigstock D, Besner G: A Novel Macrophage-Secreted Growth Factor (HB-EGF): What is the Role of Heparin Binding? Thirteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1992. Read by Dr. Whelton.Special Commendation for Excellence in Research

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Curriculum VitaeGAIL ELLEN BESNER, M.D.7. Besner G: Pediatric Burn Management. Nationwide Children's Hospital Lecture Series,

Columbus, Ohio, January, 1993. Read by Dr. Besner.

8. McCarthy D, Brigstock D, Besner G: Heparin-Binding Epidermal Growth Factor (HB-EGF) - New Implications in Wound Healing." Fourth Annual Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, January 1993. Read by Dr. McCarthy.

9. Besner G: Management of Gastroschisis. Nationwide Children's Hospital Surgical Intensive Care Unit Lecture Series, Columbus, Ohio, February, 1993. Read by Dr. Besner.

10. Besner G: HB-EGF - An Update. Nationwide Children's Hospital Research Foundation Lecture Series, Wexner Institute for Pediatric Research, Columbus, Ohio, April, 1993. Read by Dr. Besner.

11. McCarthy D, Brigstock D, Cooney D, Besner G: Characterization of a Polypeptide Growth Factor in Human Urine. Fourteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1993. Read by Dr. McCarthy.

12. Vegunta R, Brigstock, Cooney, D, Besner G: Hyper-responsiveness of Atherogenic Vascular Smooth Muscle Cells to Members of the EGF Family. Fourteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1993. Read by Dr. Vegunta. Special Commendation for Excellence in Research

13. Vegunta R, Brigstock D, Besner G, Cooney D: Specific Protein Expression by a Metastisizing Clone of Murine Neuroblastoma. Fourteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1993. Read by Dr. Vegunta.

14. Ismail N, Steffen C, Vegunta R, Kim G, Besner G, Cooney D, Brigstock D: Novel Forms of Epidermal Growth Factor in Uterine Fluids." Fourteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1993. Read by Dr. Ismail.

15. Besner G: Growth Factors and Wound Healing. Transplantation Research Conference, The Ohio State University, Columbus, Ohio, September, 1993. Read by Dr. Besner.

16. Besner G: Pediatric Thermal Injuries. Pediatric Grand Rounds, Nationwide Children's Hospital, Columbus, Ohio, January, 1994. Read by Dr. Besner.

17. Ismail N, Steffen C, Vegunta R, Kim G, Besner G, Cooney D, Brigstock D: Epidermal Growth Factor in Uterine Fluids. Fifth Annual Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, January, 1994. Read by Dr. Ismail.

18. McCarthy D, Brigstock D, Cooney D, Besner G: Urinary Heparin-Binding Growth Factor (uHBGF): A Novel Protein in Urine. Fifth Annual Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, January, 1994. Read by Dr. McCarthy. Third Prize Winner - Resident Paper Competition.

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19. Downing M, Hamoudi A, Besner G: Brain Heterotopia - Choristoma of the Back. The Toledo Surgical Society, Toledo, Ohio, February 1994. Read by Dr. Downing.

20. Besner G: Circulatory Problems. Advanced Burn Life Support Course, Nationwide Children's Hospital, Columbus, Ohio, March 1994. Read by Dr. Besner.

21. Besner G: Electrical Injury. Advanced Burn Life Support Course, Nationwide Children's Hospital, Columbus, Ohio, March 1994. Read by Dr. Besner.

22. Besner G: Chemical Injury. Advanced Burn Life Support Course, Nationwide Children's Hospital, Columbus, Ohio, March 1994. Read by Dr. Besner.

23. Besner G: Airway Management and Smoke Inhalation Injury. Advanced Burn Life Support Course, Nationwide Children's Hospital, Columbus, Ohio, March 1994. Read by Dr. Besner.

24. Besner G: Pediatric Burn Management. Advanced Burn Life Support Course, Nationwide Children's Hospital, Columbus, Ohio, March 1994. Read by Dr. Besner.

25. McCarthy D, Brigstock D, Cooney D, Besner G: Discovery of a Novel Growth Factor in Urine." Fifteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1994. Read by Dr. McCarthy.

26. Kim G, Besner G, Steffen C, McCarthy D, Brigstock: Synthesis of Heparin-binding EGF-like Growth Factor (HB-EGF) by Endometrial Tissues and its Isolation From Uterine Secretory Fluids. Fifteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1994. Read by Dr. Kim.

27. McCarthy D, Brigstock, Cooney D, Besner G: Human Burn Wound Fluid Contains Heparin-binding EGF-like Growth Factor (HB-EGF). Fifteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1994. Read by Dr. McCarthy.

28. Davis K, Brigstock D, Besner G: Expression of Heparin-binding EGF-like Growth Factor (HB-EGF) in Eucaryotic Cells Using a Vaccinia Virus Vector. Fifteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1994. Read by Dr. Davis.

29. Downing M, Brigstock D, McCarthy D, Luquette M, Besner G: Immunohistochemical Detection of Heparin-binding EGF-like Growth Factor (HB-EGF). Fifteenth Annual Nationwide Children's Hospital Research Forum, Columbus, Ohio, June 1994. Read by Dr. Downing.

30. Besner G: Comprehensive Burn Care of the Pediatric Patient. Nurses Educational Symposium Lecture Series, Columbus, Ohio, January, 1995. Read by Dr. Besner.

31. Downing MT, Brigstock DR, Luquette MH, Besner GE: Immunohistochemical Detection of Heparin-Binding EGF-Like Growth Factor in Multiple Epithelia. 50th Anniversary

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Meeting of the Columbus Surgical Society, Presidential Symposium, Columbus, Ohio, January, 1995. Read by Dr. Downing.

32. Downing M, Brigstock D, Luquette M, Besner G: Immunohistochemical Detection of Heparin-Binding EGF-Like Growth Factor in Multiple Epithelia. First Annual George F. Martin Post-Doctoral Fellow Research Day, Columbus, Ohio, February, 1995. Presented by Dr. Downing.

33. Downing M, Crissman-Combs M, Brigstock D, Besner G: Immunohistochemical Detection of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Pathology of the Skin. Toledo Surgical Society, Toledo, Ohio, March, 1995. Read by Dr. Downing.

34. Besner G: Resuscitation of Closed-Space Fire Victims. Trauma Case Review, Nationwide Children's Hospital, Columbus, Ohio, May 3, 1995. Read by Dr. Besner.

35. Harding P, Brigstock D, Besner G: Structural Organization of the Gene for Murine Heparin-Binding EGF-Like Growth Factor (HB-EGF). The 21st Annual ISCABER Graduate Research Forum, The Ohio State University, Columbus, Ohio, May 16, 1995. Presented by Dr. Harding.

36. Crissman-Combs M, Brigstock D, Besner G: Production of the Precursor Form of Heparin-Binding EGF-Like Growth Factor. The Sixteenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 2, 1995. Presented by Ms. Crissman-Combs and Dr. Besner.

37. Harding P, Brigstock D, Besner G: Structural Organization of the Gene for Murine Heparin-Binding EGF-Like Growth Factor. The Sixteenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 2, 1995. Read by Dr. Harding.

38. Downing M, McCarthy D, Brigstock D, Besner G: Antibody Affinity Purification of Urinary Heparin-Binding Growth Factor. The Sixteenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 2, 1995. Read by Dr. Downing.

39. Martinez D, O'Dorisio S, O'Dorisio T, Qualman S, Caniano D, Teich S, Besner G, King D: Application of Somatostatin Receptor Expression to the Detection and Treatment of Neuroblastoma: Radioreceptor Guided Surgery Using 125I-TYR3-Octreotide and a Gamma-Detecting Probe. The Sixteenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 2, 1995. Read by Dr. Martinez.

40. Besner G: Pediatric Burn Management. Pediatrics Grand Rounds, Nationwide Children's Hospital, Columbus, Ohio, August 24, 1995. Read by Dr. Besner.

41. Besner G: Burn Care in Children. Nursing Inservice Lecture Series, Nationwide Children's Hospital, Columbus, Ohio, November 29, 1995. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.42. Cribbs R, Luquette M, Besner G: HB-EGF Production is Associated with Cellular

Proliferation of Keratinocytes in Murine Partial-Thickness Burn Wounds. The Seventh Annual Presidential Symposium of the Columbus Surgical Society, Columbus, Ohio, Jan 13, 1996. Read by Dr. Cribbs.Second Prize Winner - Resident Paper Competition.

43. Mutabagani K, Beaver B, Cooney D, Besner G: Penetrating Neck Trauma in Children: A Reappraisal. The Seventh Annual Presidential Symposium of the Columbus Surgical Society, Columbus, Ohio, Jan 13, 1996. Read by Dr. Mutabagani.

44. Besner G: The Use of Cultured Skin in the Massively Burned Patient. The Nationwide Children's Hospital Lounge and Learn Lecture Series, Columbus, Ohio, April 5, 1996. Read by Dr. Besner.

45. Cribbs R, McCarthy D, Besner G, Kosloske A, Caniano D, Cooney D: Current Therapy for Abdominal Wall Defects. The Seventeenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 6, 1996. Read by Dr. Cribbs.

46. Davis K, Brigstock D, Johnson, Besner G: Functional Analysis of HB-EGF Glycosylation. The Seventeenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 7, 1996. Read by Dr. Davis.

47. Harding P, Brigstock D, Crissman-Combs M, Besner G: Expression of a Functional Human HB-EGF cDNA in Mouse L Cells. The Seventeenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 7, 1996. Read by Dr. Harding.

48. Cribbs R, Luquette M, Besner G: HB-EGF Production is Associated with Re-Epithelialization of Murine Partial Thickness Burn Wounds. The Seventeenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 7, 1996. Read by Dr. Cribbs.

49. Besner G: Pediatric Burn Management. Pediatric Residents’ Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, August 1, 1996. Read by Dr. Besner.

50. Besner G: Pediatric Burn Management. Psychiatry Intern Lecture Series, Nationwide Children's Hospital, Columbus, Ohio, October 18, 1996. Read by Dr. Besner.

51. Besner G: Introduction to Advanced Burn Life Support. Advanced Burn Life Support Course, Columbus, Ohio, November 17, 1996. Read by Dr. Besner.

52. Besner G: Shock and Fluid Resuscitation. Advanced Burn Life Support Course, Columbus, Ohio, November 17, 1996. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.53. Pillai S, Turman M, Besner G: Cytoprotective Effects of HB-EGF on Intestinal Epithelial

Cells. The Eigth Annual Presidential Symposium, The Columbus Surgical Society, Columbus, Ohio, January 18, 1997. Read by Dr. Pillai.First Prize Winner - Resident Paper Competition.

54. Pillai, S, Turman M, Besner G: Cytoprotective Effects of HB-EGF on Intestinal Epithelial Cells. 1997 Bernard Zimmerman Visiting Lectureship, Annual Surgery Residents Forum, Honorary Judge: Samuel A. Wells, Jr., M.D., West Virginia University, Huntington, West Virginia, March, 1997. Read by Dr. Pillai.Second Prize Winner - Resident Paper Competition.

55. Cribbs R, Luquette M, Besner G: Topical Application of HB-EGF Promotes Epithelial Cell Proliferation and Wound Re-Epithelialization in Partial-Thickness Burns. The 18th Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 5, 1997. Read by Dr. Cribbs.First Prize Winner - Graduate Student Research Competition.

56. Pillai S, Turman M, Besner G: The Cytoprotective Effects of HB-EGF on Intestinal Epithelial Cells Exposed to Hypoxia. The Eighteenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 5, 1997. Read by Dr. Pillai.Second Prize Winner - Graduate Student Research Competition.

57. Pillai S, Bethel C, Besner G, Caniano D, Cooney D: Fall Injuries in the Pediatric Population: The Need for Safe, Cost-Effective Management. The Eighteenth Annual Nationwide Children's Hospital Research Foundation Research Forum, Columbus, Ohio, June 5, 1997. Read by Dr. Pillai.

58. Besner G: Pediatric Burn Management. Pediatric Residents’ Lecture Series. Nationwide Children’s Hospital, Columbus, Ohio, July 23, 1997. Read by Dr. Besner.

59. Besner G: Pediatric Burn Management. Psychiatry Intern Lecture Series, Nationwide Children's Hospital, Columbus, Ohio, November 11, 1997. Read by Dr. Besner.

60. Pillai S, Luquette M, Nowicki P, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Small Intestinal Ischemia/Reperfusion Injury in Rats. Ninth Annual Presidential Symposium, The Columbus Surgical Society, Columbus, Ohio, January, 1998. Read by Dr. Pillai.First Prize Winner - Resident Paper Competition.

61. Pillai S, Bethel C, Besner G, Caniano D, Cooney D: Fall Injuries in the Pediatric Population: Safer and More Cost-Effective Management. Ninth Annual Presidential

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Symposium, The Columbus Surgical Society, Columbus, Ohio, January, 1998. Read by Dr. Pillai.

62. Mutabagani K, Zumberge N, Coley B, Martin L, Shiels W, McCarthy D, Besner G, Caniano D, Cooney D: Preliminary Experience with Focused Abdominal Sonography (FAST) for Trauma in Children: Is it Useful? Ninth Annual Presidential Symposium, The Columbus Surgical Society, Columbus, Ohio, January, 1998. Read by Dr. Mutabaani.

63. Besner G: Caring for the Pediatric Burn Patient – Stabilizing and Packaging the Pediatric Burn Patient for Transport. Partner’s in Children’s Health Subregional Lecture Series, Marion General Hospital, Marion, Ohio, February 24, 1998. Read by Dr. Besner.

64. Vegunta, R, Edwards A, Besner G: Extensive Peritoneal Irrigation in Children Undergoing Appendectomy for Ruptured Appendicitis: Is it Beneficial or Harmful? The Nineteenth Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 1998. Read by Ms. Edwards.

65. Mutabagani K, Zumberge N, Coley B, Martin L, Shields W, Luria J, McCarthy D, Besner G, Caniano D, Cooney D: Preliminary Experience with Focused Abdominal Ultrasonography for Children (FAST): Is it Useful? The Nineteenth Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 1998. Read by Dr. Mutabagani.

66. Pillai S, Luquette M, Nowicki P, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Reduces Small Intestinal Ischemia/Reperfusion Injury in Rats. The Nineteenth Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 1998. Presented by Dr. Pillai.

67. Besner G: Pediatric Burn Management. Pediatric Residents’ Lecture Series. Nationwide Children’s Hospital, Columbus, Ohio, July 29, 1998. Read by Dr. Besner.

68. Besner G: Management of the Pediatric Burn Patient. Resident Lecture Series, Doctor’s West Hospital, Columbus, Ohio, October 21, 1998. Read by Dr. Besner.

69. Hinman C, Downing M, Luquette M, Besner G: A Model of Intestinal Ischemia-Reperfusion Injury in Weanling Rats. Tenth Annual Presidential Symposium, The Columbus Surgical Society, Columbus, Ohio, February 20, 1999. Read by Dr. Hinman.Second Prize Winner - Resident Paper Competition.

70. Besner G: Abdominal Pain: My Tummy Hurts. Family Medicine Grand Rounds, The Ohio State University, Columbus, Ohio, March 17, 1999. Read by Dr. Besner.

71. Vegunta R, Rauck A, Morotti R, Shiels W, Besner G: Collision of Mesoblastic Nephroma and Neuroblastoma in an Infant. The Twentieth Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 1999. Read by Dr.Vegunta.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.72. Hinman C, Downing M, Luquette M, Besner G: A Model for Intestinal

Ischema/Reperfusion Injury in Weanling Rats. The Twentieth Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 1999. Read by Dr. Downing.

73. Pillai S, Turman M, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) is Cytoprotective for Intestinal Epithelial Cells Exposed to Hypoxia. Fourth Annual Resident’s Research Conference, The Ohio State University College of Medicine, Columbus, Ohio, June, 1999. Read by Dr. Pillai.First Prize Winner - Resident's Paper Competition

74. Besner G: Pediatric Burn Management. Pediatric Residents’ Lecture Series. Nationwide Children’s Hospital, Columbus, Ohio, August 19, 1999. Read by Dr. Besner.

75. Besner G: Care of the Pediatric Burn Patient. Psychology Intern Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, November 12, 1999. Read by Dr. Besner.

76. Besner G: Necrotizing Enterocolitis: From Bench to Bedside. Medical Scientist Program Seminar Series, The Ohio State University College of Medicine, Columbus, Ohio, November 18, 1999. Read by Dr. Besner.

77. Besner G: Testicular Problems and Varicoceles. Lounge and Learn Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, January, 2000. Read by Dr. Besner.

78. Michalsky M and Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Modulates Nitric Oxide Production in Intestinal Epithelial Cells. Tenth Annual Presidential Symposium, The Columbus Surgical Society, Columbus, Ohio, February 26, 2000. Read by Dr. Michalsky.First Prize Winner – Resident Paper Competition

79. Michalsky M, Downing M, Lara-Marquez M, Besner G: Endogenously- Produced Heparin-Binding EGF-Like Growth Factor HB-EGF): A Potential Role in Neonatal Intestinal Physiology. The Twenty-first Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 2000. Read by Dr.MichalskyFirst Prize Winner - Resident Paper Competition

80. Michalsky M and Besner G: Heparin-Binding EGF-like Growth Factor (HB-EGF) Modulates Apoptosis in Intestinal Epithelial Cells in Vitro. The Twenty-first Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 2000. Read by Dr.Michalsky

81. Lara-Maruez M, Michalsky M, Furchner M, Besner G: Proinflammatory Cytokine-Induced Nitric Oxide is Down-Regulated in Human Intestinal Epithelial Cells by Heparin-Binding EGF-Like Growth Factor (HB-EGF). The Twenty-first Annual Nationwide Children’s Hospital Research Foundation Research Forum, Children’s Hospital, Columbus, Ohio, June 2000. Read by Dr.Lara-MarquezThird Prize Winner - Resident Paper Competition

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82. Besner G: Pediatric Burn Management. Pediatric Residents’ Lecture Series. Nationwide Children’s Hospital, Columbus, Ohio, August 21, 2000. Read by Dr. Besner.


84. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. Central Ohio Pediatric Society, Invited Lecture, Columbus, Ohio, November, 2000. Read by Dr. Besner.

85. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. American Association for Laboratory Animal Science Annual Meeting, Columbus, Ohio, November, 2000. Read by Dr. Besner.

86. Besner G: Advances in Surgery (Separation of Conjoined Twins). Ohio Medical Education Network, The Ohio State University, Columbus, Ohio, January 12, 2001. Read by Dr. Besner.

87. Kuhn A, Michalsky M, Mehta V, Glenn S, Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Decreases Leukocyte-Derived Oxygen Free Radical Production. Eleventh Annual Presidential Symposium, The Columbus Surgical Society, Columbus, Ohio, March 3, 2001. Read by Dr. Kuhn.

88. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. TWIGS of Children's Hospital, Invited Lecture, Columbus, Ohio, March 13, 2001. Read by Dr. Besner.

89. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. Licking County Medical Society Meeting, Invited Lecture, Newark, Ohio, March 29, 2001. Read by Dr. Besner.

90. Besner G; Heparin-Binding EGF-Like Growth Factor and Intestinal Ischermia/Reperfusion Injury, Research Presentation to Visiting Professor Mark Rowe, Department of Pediatric Surgery Visiting Professor Series, Nationwide Children’s Hospital, Columbus, Ohio, March, 2001. Read by Dr. Besner.

91. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. Anatomy and Medical Education and Neuroscience Seminar Series, Invited Lecture, The Ohio State University, Columbus, Ohio, April 4, 2001. Read by Dr. Besner.

92. Besner G; Heparin-Binding EGF-Like Growth Factor and Intestinal Ischermia/Reperfusion Injury, The Research Institute at Nationwide Children’s Hospital Annual Retreat, Newark, Ohio, April, 2001. Read by Dr. Besner.

93. Besner G: Heparin-Binding EGF-Like Growth Factor and Intestinal Ischemia/Reperfusion Injury, Department of Surgery Research Meeting, The Ohio State University, Columbus, Ohio, April 10, 2001. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.94. Kuhn A, Michalsky M, Glenn S, Mehta V, Besner G: Heparin-Binding EGF-Like Growth

Factor (HB-EGF) Decreases Oxygen Free Radical Production. Twenty-second Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, June 1, 2001, Columbus, Ohio. Read by Dr. Kuhn.First Prize Winner-Resident Research Competition

95. Xia G and Besner G; Heparin-Binding EGF-Like Growth Factor (HB-EGF) Preserves Crypt Cell Proliferation and Decreases Bacterial Translocation After Intestinal Ischemia/Reperfusion Injury. Twenty-second Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, Columbus, Ohio, June 1, 2001. Read by Dr. Xia.

96. Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) and Intestinal Ischemia/Reperfusion Injury. Integrated Biomedical Sciences Graduate Program Faculty Lecture Series, Columbus, Ohio, June, 21, 2001. Read by Dr. Besner.

97. Besner G: Pediatric Burn Management. Pediatrics Grand Rounds, Nationwide Children’s Hospital, Columbus, Ohio. August 9, 2001. Read by Dr. Besner.

98. Besner G: Introduction to Advanced Burn Life Support. Advanced Burn Life Support Course, Columbus, Ohio, September 27, 2001. Read by Dr. Besner.

99. Besner G: Initial Assessment and Management. Advanced Burn Life Support Course, Columbus, Ohio, September 27, 2001. Read by Dr. Besner.

100. Besner G: Wound Management. Advanced Burn Life Support Course, Columbus, Ohio, September 27, 2001. Read by Dr. Besner.

101. Besner G: Pediatric. Advanced Burn Life Support Course, Columbus, Ohio, September 27, 2001. Read by Dr. Besner.

102. Besner G: Care of the Pediatric Burn Patient. Burn Nurse Orientation Seminar Series, Nationwide Children’s Hospital, Columbus, Ohio, November, 2001. Read by Dr. Besner.


104. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. Children’s Hospital Foundation, Invited Lecture, Nationwide Children’s Hospital, Columbus, Ohio, November 14, 2001. Read by Dr. Besner.

105. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. Children’s Hospital Foundation, Invited Lecture, Upper Arlington Rotary Club, Upper Arlington, Ohio, March 12, 2001. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.106. Besner G: Pediatric Varicoceles. Pediatric Surgery Seminar Series, Nationwide Children’s

Hospital, Columbus, Ohio, March 27, 2002. Read by Dr. Besner.

107. Besner G: Pediatric Varicoceles. Pediatrics Lounge and Learn Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, April 12, 2002. Read by Dr. Besner.

108. Besner G: The Road to Separation: A Story of Conjoined Twins From Africa. Presentation to Nationwide Children’s Hospital Board of Trustees, Invited Lecture, Columbus, Ohio, April 18, 2002. Read by Dr. Besner.

109. Besner G: Pediatric Burn Management. CME Lecture Series, Good Samaritan Hospital, Zanesville, Ohio, June 26, 2002. Read by Dr. Besner.

110. Besner G: Chemical Burns. Advanced Burn Life Support Course, Columbus, Ohio, July 25, 2002. Read by Dr. Besner.

111. Besner G: Pediatric Burns. Advanced Burn Life Support Course, Columbus, Ohio, July 25, 2002. Read by Dr. Besner.


113. Martin A, Luquette M, Besner G: HB-EGF Prophylactic and Salvage Therapy for Intestinal Ischemia/Reperfusion Injury. The Columbus Surgical Society Presidential Symposium, May, 2003, Columbus, Ohio. Read by Dr. Martin.

114. Besner G: The Surgical Separation of Conjoined Twins. Surgery Grand Rounds, The Ohio State University, Columbus, Ohio, May 8, 2003. Read by Dr. Besner.

115. Besner G and Davis T: Conjoined Twins-Case Report. Ohio Medical Education Network, The Ohio State University, Columbus, Ohio, May 16, 2003. Read by Dr. Besner.

116. Martin A, Luquette M, Besner G: HB-EGF Prophylactic and Salvage Therapy for Intestinal Ischemia-Reperfusion Injury. Twenty-fourth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, May 29, 2003, Columbus, Ohio. Presented by Dr. Martin.

117. Martin A, Luquette M, Besner G: Inhalation Versus Intraperitoneal Anesthesia Does Not Affect Outcome in a Rat Intestinal Ischemia-Reperfusion Model. Twenty-fourth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, May 29, 2003, Columbus, Ohio. Presented by Dr. Martin.

118. Corpron C, Martin A, Roberts G, Besner G: The Pediatric Burn Unit: A Profit Center. Twenty-fourth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, May 29, 2003, Columbus, Ohio. Presented by Dr. Martin.

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119. Mehta V and Besner G: Heparin-Binding EGF-Like Growth Factor (HB-EGF) Suppresses NF-B Activation and Modulates Immune Responses. Twenty-fourth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, May 29, 2003, Columbus, Ohio. Presented by Dr. Mehta

120. Besner G: The Surgical Separation of Thoracopagus Conjoined Twins. Presentation to the Joint Conference Committee of the Board of Trustees, Nationwide Children’s Hospital, Columbus, Ohio, August 27, 2003. Read by Dr. Besner.

121. Besner G: Pediatric Burns. Invited Lecture to the Norwich Township Fire Department, Norwich, Ohio, September 23, 2003. Read by Dr. Besner.

122. Besner G: HB-EGF and Intestinal Ischemia-Reperfusion Injury. Cell and Vascular Biology Center Research Presentation Series, Nationwide Children’s Hospital, Columbus, Ohio, September, 24, 2003. Read by Dr. Besner.

123. El-Assal O and Besner G: HB-EGF Improves Gut Permeability and Intestinal Restitution after Intestinal Ischemia/Reperfusion in a PI3-Dependent Fashion. Twenty-fifth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, April 14, 2004, Columbus, Ohio. Read by Dr. El-Assal.First Prize Winner-Resident Research Competition

124. Besner G: Pediatric Burn Management. Pediatrics Grand Rounds, Nationwide Children’s Hospital, Columbus, Ohio, August 5, 2004. Read by Dr. Besner.

125. Besner G: The Acute Abdomen in Infants and Children. The Ohio State University College of Medicine and Public Health, Medical Student Lecture Series, Columbus, Ohio, August 6, 2004. Read by Dr. Besner.

126. Besner G: HB-EGF and Intestinal Ischemia-Reperfusion Injury. Cell and Vascular Biology Center Research Presentation Series, Nationwide Children’s Hospital, Columbus, Ohio, October, 2004. Read by Dr. Besner.

127. Besner G: The Surgical Separation of Conjoined Twins. The Ohio State University College of Medicine and Public Health, Alpha Epsilon Delta Premedical Society Lecture Series, Columbus, Ohio, January 12, 2005. Read by Dr. Besner.

128. Besner G: The Surgical Separation of Conjoined Twins. Association of Operating Room Nurses Lecture Series, Columbus, Ohio, February 12, 2005. Read by Dr. Besner.

129. Besner G: Pediatric Burn Management., Prarie Township Fire Department, Prarie Township, Ohio, August 18, 2005. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.130. Besner G: The Surgical Separation of Conjoined Twins. Pediatric Surgery Teaching

Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, August 2, 2005. Read by Dr. Besner.

131. Besner G: Pediatric Burn Management. Pediatrics Grand Rounds, Nationwide Children’s Hospital, Columbus, Ohio, August 4, 2005. Read by Dr. Besner.

132. Besner G: Pediatric Burn Management. Grand Rounds, Zanesville, Ohio, September 9, 2005. Read by Dr. Besner.

133. Besner G: Molecular Biology for the Pediatric Surgeon. Pediatric Surgery Basic Science Journal Club Series, Nationwide Children’s Hospital, Columbus, Ohio, October 19, 2005. Read by Dr. Besner.

134. Besner G: HB-EGF and Intestinal Injury. Cell and Vascular Biology Center Research Presentation Series, Nationwide Children’s Hospital, Columbus, Ohio, December 9, 2005. Read by Dr. Besner.

135. Besner G: Pediatric Burn Management. EMS Lecture Series, Worthington, Ohio, January 28, 2006. Read by Dr. Besner.

136. Rocourt D, Mehta V, Besner G: HB-EGF Decreases Neutrophil-Endothelial Cell Adhesion after Anoxia/Reoxygenation Injury. The Columbus Surgical Society Presidential Symposium, Columbus, Ohio, February 25, 2006. Read by Dr. Rocourt.

137. Besner G: Pediatric Burn Management: Past and Present. Pediatric Pearls Conference, Nationwide Children’s Hospital, Columbus, Ohio, March 23, 2006. Read by Dr. Besner.

138. El-Assal O and Besner G: HB-EGF Enhances Intestinal Restitution in vitro via Activation of the ErbB/Src/FAK Pathway. Twenty-sixth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, Columbus, Ohio, April 3, 2006. Presented by Dr. El-Assal.

139. Mehta V and Besner G: Activation of the PI3-Kinase Pathway Mediates HB-EGF-Induced Endothelial Cell Wound Healing and Angiogenesis. Twenty-sixth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, Columbus, Ohio, April 3, 2006. Presented by D. Mehta.

140. Rocourt D, Mehta V, Besner G: HB-EGF Decreases Neutrophil-Endothelial Cell Adhesion after Anoxia/Reoxygenation Injury. Twenty-sixth Annual Nationwide Children’s Hospital Research Institute Research Forum, Children’s Hospital, Columbus, Ohio, April 3, 2006. Read by Dr. Rocourt.First Prize Winner-Resident Research Competition

141. Besner G: Pediatric Burn Management. Critical Care Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, June 30, 2006. Read by Dr. Besner.

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142. Besner G: Pediatric Burn Management. Critical Care Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, December 7, 2006. Read by Dr. Besner.

143. Besner G: Care of the Pediatric Burn Patient. Psychology Intern Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, December 7, 2006. Read by Dr. Besner.

144. El-Assal O and Besner G: HB-EGF Preserves Mesenteric Microcirculatory Blood Flow and Protects against Intestinal Injury in Rats Subjected to Hemorrhagic Shock and Resuscitation. Twenty-seventh Annual Nationwide Children’s Research Institute Research Forum, Children’s Hospital, Columbus, Ohio, April 5, 2007. Presented by Dr El-Assal.

145. Besner G: Pediatric Burn Management. Pediatrics Grand Rounds, Marion General Hospital, Zanesville, Ohio, April 18, 2007. Read by Dr. Besner.

146. Besner G: Proposed HB-EGF Clinical Trial for NEC. Pediatric Surgery Basic Science Journal Club, Nationwide Children’s Hospital, Columbus, Ohio, July 18, 2007. Read by Dr. Besner.

147. Besner G: Necrotizing Enterocolitis. Pediatric Surgery Tutorial Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, August 1, 2007. Read by Dr. Besner.

148. Besner G: Pediatric Burn Management. Pediatrics Grand Rounds, Nationwide Children’s Hospital, Columbus, OH, August 9, 2007. Read by Dr. Besner.

149. Paddock H, Fabia R, Giles S, Hayes J, Lowell W, Besner G: A Silver Impregnated Antimicrobial Dressing Reduces Length of Stay and Cost for Pediatric Burn Patients. Great Lakes Burn Association Meeting, Columbus, Ohio, September 27, 2007. Read by Dr. Besner.

150. Besner G: Care of the Pediatric Burn Patient. Psychology Intern Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, December 7, 2007. Read by Dr. Besner.

151. Besner G: Pediatric Burn Management. Critical Care Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, December 6, 2007. Read by Dr. Besner.

152. Besner G: Initial Assessment and Management. Advanced Burn Life Support Course, Columbus, Ohio, January 11, 2008. Read by Dr. Besner.

153. Besner G: Airway Management and Smoke Inhalation. Advanced Burn Life Support Course, Columbus, Ohio, January 11, 2008. Read by Dr. Besner.

154. Besner G: Protection of the Intestines from Necrotizing Enterocolitis with Heparin-Binding EGF-Like Growth Factor (HB-EGF). Gastrenterology Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, January 17, 2008. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.155. Radulescu A, El-Assal O, Besner G: HB-EGF - From Bench to Bedside, Columbus

Surgical Society Annual Presidential Symposium, Columbus, Ohio, Feb 16, 2008. Read by Dr. Radulescu. Bronze Medal Winner - Resident Research Award

156. Radulescu A, El-Assal O, Besner G: Targeting NEC: From Bench to Bedside, Ohio State University Medical Center Research Day, Columbus, Ohio, April 10, 2008. Presented by Dr. Radulescu. Resident Research Award Winner

157. Zorko N, Radulescu A, Besner G: Production of a Murine Model of Necrotizing Enterocolitis. Ohio State University Medical Center Research Day, Columbus, Ohio, April 10, 2008. Presented by N. Zorko.

158. Ryan M, Radulescu A, El-Assaal, O, Mehta V, Besner G: Mechanisms of HB-EGF-Induced Angiogenesis During Healing From Intestinal Injury. Ohio State University Medical Center Research Day, Columbus, Ohio, April 10, 2008. Presented by M Ryan.

159. Radulescu A, Yu, X El-Assal O, Besner G: HB-EGF: From Bench to Bedside. Nationwide Children’s Hospital Research Retreat, Columbus, Ohio, March 13, 2008. Presented by Dr. Radulescu.

160. Yu X, Radulescu A, Besner G: HB-EGF Therapy Increases Villous Microcirculatory Blood Flow in Rat PUPS with Experimental NEC. Nationwide Children’s Hospital Research Retreat, Columbus, Ohio, March 13, 2008. Presented by Dr. Yu.

161. Mehta V and Besner G: HB-EGF Promotes eNOS Dependent Angiogenesis in Endothelial Cells. Nationwide Children’s Hospital Research Retreat, Columbus, Ohio, March 13, 2008. Presented by Dr. Mehta.

162. Zhou Y and Besner G: Heparin Binding EGF-Like Growth Factor Dilates Terminal Mesenteric Arterioles via Upregulation of ETB Receptors. Nationwide Children’s Hospital Research Retreat, Columbus, Ohio, March 13, 2008. Read by Dr. Zhou.

163. Besner G: Protection of the Intestines from Necrotizing Enterocolitis with Heparin-Binding EGF-Like Growth Factor (HB-EGF). Neonatology Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, February 20, 2008. Read by Dr. Besner.

164. Besner G: Pediatric Burns. Pediatrics Grand Rounds. Nationwide Children’s Hospital, Columbus, Ohio, July 17, 2008. Read by Dr. Besner.

165. Besner G: Shock. Advanced Burn Life Support Course, Columbus, Ohio, September 3, 2008. Read by Dr. Besner.

166. Besner G: Pediatrics. Advanced Burn Life Support Course, Columbus, Ohio, September 3, 2008. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.167. Besner G: Pediatric Burn Management. EMS Lecture Series, Monroe Township Fire

Department, Johnstown, Ohio, September 15, 2008. Read by Dr. Besner.

168. Besner G: Care of the Pediatric Burn Patient. Psychology Intern Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, October 23, 2008. Read by Dr. Besner.

169. Zhang H-Y, Radulescu A, Besner G: HB-EGF is Essential for Preservation of Gut Barrier Function after Hemorrhagic Shock and Resuscitation in Mice. Third Annual International Scholar Research Exposition, The Ohio State University, Columbus, Ohio, November 3, 2008. Presented by Dr. Zhang.

170. Besner G: Burned Kids. Fire and Ice, State Firemarshall’s Office, Ohio Fire Academy, Reynoldsburg, Ohio, November 8, 2008. Read by Dr. Besner.

171. Besner G: Pediatric Burn Management. Columbus Fire House, Columbus, Ohio, November 19, 2008. Read by Dr. Besner.

172. Radulescu A, Yu X, Chen Y, Besner G: HB-EGF Knockout Mice Have Increased Susceptibility to Necrotizing Enterocolitis. Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, February 28, 2009. Read by Dr. Radulescu.Gold Medal Winner - Resident Research Award

173. Radulescu A, Yu D, Zhang H-Y, Besner G: Preclinical Neonatal Rat Studies of Heparin-Binding EGF-Like Growth Factor in the Protection of the Intestines from Necrotizing Enterocolitis. The Ohio State University Medical Center Research Day, Ohio State University, Columbus, Ohio, April 2, 2009. Presented by Dr. Radulescu.

174. Yu X, Radulescu A, Besner, G: HB-EGF Preserves Intestinal Microvasculature and Structural Architecture in Premature Rat Pups with Experimental necrotizing enterocolitis. The Ohio State University Medical Center Research Day, Ohio State University, Columbus, Ohio, April 2, 2009. Presented by Dr. Yu.

175. Orvets N, Radulescu A, Khalfoun S, Zorko N, Zhang H-Y, Besner G: HB-EGF

Knockout Mice Exposed to Experimental Necrotizing Enterocolitis have Increased Intestinal Permeability. The Ohio State University Medical Center Research Day, Ohio State University, Columbus, Ohio, April 2, 2009. Presented by N. OrvetsTravel Research Award (NO)

176. Besner G: Pediatric Burn Management. The Pediatric Surgery Tutorial Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, April 15, 2009. Read by Dr. Besner.

177. Radulescu A, Yu D, Zhang H-Y, Besner G: Preclinical Neonatal Rat Studies of Heparin-Binding EGF-Like Growth Factor in the Protection of the Intestines from Necrotizing Enterocolitis. The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, Ohio, May 15, 2009. Read by Dr. Radulescu.

178. Yu X, Radulescu A, Besner, G: HB-EGF Preserves Intestinal Microvasculature and Structural Architecture in Premature Rat Pups with Experimental Necrotizing Enterocolitis.

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The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, Ohio, May 15, 2009. Read by Dr. Yu.

179. Zhang H-Y, Radulescu A, Besner G: HB-EGF is Essential for Preservation of Gut Barrier Function after Hemorrhagic Shock and Resuscitation in Mice. The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, Ohio, May 15, 2009. Presented by Dr. Zhang.

180. Rocourt D, Hall M, Kenney B, Fabia R, Groner J, Besner G: Respiratory Failure after Pediatric Scald Injury: Does Altered Immune Function Play a Role? The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, Columbus, Ohio, May 15, 2009. Presented by Dr. Rocourt.

181. Besner G: Pediatric Burn Management. Pediatric Critical Care Lecture Series, Nationwide Children’s Hospital, June 4, 2009. Read by Dr. Besner..

182. Besner G: Pediatric Burn Management. Pediatrics Residency Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, July 10, 2009. Read by Dr. Besner.

183. Besner G: Pediatric Burn Management. Psychology Trainee Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, September 17, 2009. Read by Dr. Besner.

184. Zhang H-Y, Radulescu A, Chen Y, Chen, C-L, Besner G: Mice Overexpressing the Gene for Heparin-Binding EGF-Like Growth Factor Have Increased Resistance to Hemorrhagic Shock and Resuscitation. 4th Annual International Scholar Research Exhibition, The Ohio State University College of Medicine, November 19, 2009. Presented by Dr. Zhang.

185. Radulescu A, Zhang H-Y, Chen C-L, Chen Y, Zhou Y, Yu X, Otabor I, Olson J, Besner G: Expression Levels of Heparin-Binding EGF-Like Growth Factor Affect Intestinal Anastomotic Wound Healing. Columbus Surgical Society, Columbus, Ohio, February 6, 2010. Read by Dr. Radulescu.

186. Otabor I, Chen C-L, Huang G, Zhang H-Y, Velten M, Besner G: HB-EGF Protects the Lungs from Intestinal Ischemia/Reperfusion Injury. Columbus Surgical Society, Columbus, Ohio, February 6, 2010. Read by Dr. Otabor.Gold Medal Winner – Resident’s Paper Competition (IO)

187. Radulescu A, Zhang H-Y, Chen C-L, Chen Y, Zhou Y, Besner G: Expression Levels of Heparin-Binding EGF-Like Growth Factor affect Intestinal Anastomotic Wound Healing. Ohio State University Medical Center Research Day, Columbus, Ohio, April 8, 2010. Presented by Dr. Radulescu. Post-doctoral Fellow Research Award (AR)

188. Yu X, Radulescu A, Chen C-L, Besner G: Heparin-binding EGF-like Growth Factor Protects Pericytes from Injury. Ohio State University Medical Center Research Day. Ohio State University, Columbus, Ohio, April 8, 2010. Presented by Dr. Yu.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.189. Otabor I, Chen C-L, Huang G, Zhang H-Y, Velten M, Besner G: HB-EGF Protects the

Lungs from Intestinal Ischemia/Reperfusion Injury. Ohio State University Medical Center Research Day. Ohio State University, Columbus, Ohio, April 8, 2010. Read by Dr. Otabor.

190. Olson J, Radulescu A, Zhang, H-Y, Yu X, Darbyshire A, Chen Y, Besner G: Heparin-binding EGF-like Growth Factor Overexpression in Transgenic Mice Decreases Susceptibility to Necrotizing Entrocolitis. Ohio State University Medical Center Research Day. Ohio State University, Columbus, Ohio, April 8, 2010. Presented by J Olson.

191. Zhou Y, Besner G: Heparin-Binding EGF-Like Growth Factor Promotes Enteric Neural Cell Migration. Ohio State University Medical Center Research Day. Ohio State University, Columbus, Ohio, April 8, 2010. Presented by Dr. Zhou.

192. Zhang H-Y, Radulescu A, Besner G: Mice Overexpressing the Gene for Heparin-Binding EGF-like Growth factor Have Increased Resistance to Hemorrhagic Shock and Resuscitation. Ohio State University Medical Center Research Day. Ohio State University, Columbus, Ohio, April 8, 2010. Presented by Dr. Zhang.

193. Radulescu A, Zhang H-Y, Chen C-L, Chen Y, Zhou Y, Otabor I, Olson J, Besner G: Expression Levels of Heparin-Binding EGF-Like Growth Factor affect Intestinal Anastomotic Wound Healing. The Research Institute at Nationwide Children’s Hospital Research Day, Columbus, Ohio, April 9, 2010. Presented by Dr. Radulescu.

194. Yu X, Radulescu A, Chen C-L, Besner G: Heparin-binding EGF-like Growth Factor Protects Pericytes from Injury. The Research Institute at Nationwide Children’s Hospital Research Day, Columbus, Ohio, April 9, 2010. Presented by Dr. Yu.

195. Zhang H-Y, Radulescu A, Besner G: Mice Overexpressing the Gene for Heparin-Binding EGF-like Growth factor Have Increased Resistance to Hemorrhagic Shock and Resuscitation. The Research Institute at Nationwide Children’s Hospital Research Day, Columbus, Ohio, April 9, 2010. Presented by Dr. Zhang.

196. Otabor I, Chen C-L, Huang G, Zhang H-Y, Velten M, Besner G: HB-EGF Protects the Lungs from Intestinal Ischemia/Reperfusion Injury. The Research Institute at Nationwide Children’s Hospital Research Day, Columbus, Ohio, April 9, 2010. Read by Dr. Otabor.

197. Zhou Y, Besner G: Heparin-Binding EGF-Like Growth Factor Promotes Enteric Neural Cell Migration. The Research Institute at Nationwide Children’s Hospital Research Day, Columbus, Ohio, April 9, 2010. Presented by Dr. Zhou.

198. James IO, Druhan S, Caniano D, Besner G: The Presence but not the Location of an Appendicolith affects the Success Rate of Interval Appendectomy in Children. Ohio Chapter of the American College of Surgeons, Columbus, Ohio, May 7, 2010. Read by Dr. James (Otabor)Second Place Prize – Clinical Category

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199. Otabor I, Besner G: HB-EGF Protects the Lungs from Intestinal Ischemia/Reperfusion Injury. Zollinger Visiting Professorship Resident Lecture, The Ohio State University College of Medicine, Columbus, Ohio, May 5, 2010. Read by Dr. Otabor.

200. Askegard-Giesmann J, Kenney, Besner G: ECMO for Pediatric Burns. Central Ohio Trauma System, First Annual Trauma Research Symposium, May 7, 2010, Columbus, Ohio. Read by Dr. Askegard-Giesmann.

210. Besner G: Big News for Small Babies. Dinner with the Doctors, Columbus, Ohio, May 27, 2010. Read by Dr. Besner.

211. Besner G: Physiology of Infection. Pediatric Surgery Tutorial Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, June 2, 2010. Read by Dr. Besner.

212. Besner G: Necrotizing Enterocolitis Update. Pediatrics Grand Rounds, Nationwide Children’s Hospital, Columbus, Ohio. June 15, 2010. Read by Dr. Besner.

213. Besner G: Pediatric Burn Management. Psychology Trainee Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, October 20, 2010. Read by Dr. Besner.

214. Besner G: Big News for Small Intestines. Annual Carol Goldsmith Lecture Series, Wellington High School, Columbus, Ohio, November 5, 2010. Read by Dr. Besner.

215. Zhang H-Y, James I, Chen C-L, Wetzl A, Radulescu A, Besner G: Heparin-Binding EGF-Like Growth Factor Preserves Gut Barrier Function by Blocking Neutrophil-Endothelial Cell Adhesion after Hemorrhagic Shock and Resuscitation in Mice. 5th Annual International Scholar Research Exhibition, The Ohio State University College of Medicine, Columbus, Ohio, November 17, 2010. Presented by Dr. Zhang.

217. Besner G: Necrotizing Enterocolitis. Neonatology Grand Rounds, Nationwide Children’s Hospital. Columbus, Ohio, January 28, 2011. Read by Dr. Besner.

216. Radulescu R, Zhang, H-Y, Yu X, Olson J, Darbyshire A, Chen Y, Besner G: Heparin-Binding EGF-Like Growth Factor Overexpression in Transgenic Mice Increases Resistance to Necrotizing Enterocolitis. Columbus Surgical Society, Columbus, Ohio, March 6, 2011. Read by Dr. Radulescu.

217. James I, Zhang H-Y, Chen C-L, Wetzl A, Radulescu A, Besner G: Heparin-binding EGF-Like Growth Factor Preserves Gut Barrier Function by Blocking Neutrophil-Endothelial Cell Adhesion after Hemorrhagic Shock and Resuscitation in Mice. Columbus Surgical Society, Columbus, Ohio, March 6, 2011. Read by Dr. James.

218. James I, Zhang H-Y, Chen C-L, Wetzl A, Radulescu A, Besner G: Heparin-binding EGF-like Growth Factor Preserves Gut Barrier Function after Hemorrhagic Shock and Resuscitation in Mice. The 22nd Annual Presidential Symposium of the Columbus Surgical Society, Columbus, Ohio, March 12, 2011. Read by Dr. James.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.219. Yang J, Chen C-L, Watkins D, Zhang H-Y, Besner G: Heparin-binding EGF-like

Growth Factor (HB-EGF) and Mesenchymal Stem Cells (MSC) Act Synergistically to Prevent Experimental Necrotizing Enterocolitis. Nationwide Children’s Hospital / Ohio State University Research Week, April 14, 2011. Presented by Dr. Yang.

220. Radulescu A, Yang J, Chen C-L, Zhang H-Y, James I, Besner G: Heparin-bi9nding EGF-like Growth Factor (HB-EGF) Improves Intestinal Barrier Function and Reduces Mortality in a Murine Model of Peritonitis. Nationwide Children’s Hospital / Ohio State University Research Week, April 14, 2011. Presented by Dr. Radulescu.

221. James I, Zhang H-Y, Chen C-L, Wetzl A, Radulescu A, Besner G: Heparin-binding EGF-like Growth Factor Preserves Gut Barrier Function by Blocking Neutrophil-Endothelial Cell Adhesion after Hemorrhagic Shock and Resuscitation in Mice. 16th Annual Ohio State University Surgical Research Conference, Columbus, Ohio, June 10, 2011. Read by Dr. James.Winner – Third Place Research Prize

222. Besner G: Pediatric Burn Management. Pediatrics Acute Care Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, August 24, 2011. Read by Dr. Besner.

223. Yang J, Besner G: Heparin-binding EGF–like Growth Factor (HB-EGF) Protects the Intestines in Vivo by Inducing Mediators of Restitution in Murine Necrotizing Enterocolitis. 6th Anual International Scholar Research Exhibition, The Ohio State University College of Medicine, November 19, 2011. Presented by Dr.Yang.

224. Su Y, Yang J, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Promotes Intestinal Restitution in Vitro by Enhancing Epithelial Cell-Matrix (ECM) Interactions. 6th Annual International Scholar Research Exhibition, The Ohio State University College of Medicine, November 19, 2011. Presented by Dr.Su

225. Besner G: Initial Assessment and Management. Advanced Burn Life Support Course, Columbus, Ohio, November 30, 2011. Read by Dr. Besner.

226. Besner G: Airway Management and Smoke Inhalation. Advanced Burn Life Support Course, Columbus, Ohio, November 30, 2011. Read by Dr. Besner.

227. Besner G: Shock. Advanced Burn Life Support Course, Columbus, Ohio, November 30, 2011. Read by Dr. Besner.

228. Besner G: HB-EGF Therapy for Necrotizing Enterocolitis. Nationwide Children’s Hospital Lounge and Learn Series, Columbus, Ohio, January 13, 2012. Read by Dr. Besner.

229. Besner G: Congenital Anomalies of the Esophagus. Pediatruc Surgery Tutorial Lecure Series, Nationwide Children’s Hospital, Columbus, Ohio, January 18, 2012. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.230. Watkins D, Chen C-L, Besner G: Heparin-binding EGF-Like Growth Factor Protects

Mesenchymal Stem Cells. Columbus Surgical Society, Columbus, Ohio, March 3, 2012. Read by Dr.Watkins. Winner – First Place Research Prize

231. Zhou Y, Yang J, Besner G: Neural Stem Cells Genetically Engineered to Overexpress HB-EGF Restore Intestinal Motility in Rat Pups Subjected to Necrotizing Enterocolitis. Nationwide Children’s Hospital Research Poster Competition, Columbus, Ohio, April 18, 2012. Presented by Dr. Zhou.

232. Su, Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Promotes Intestinal Epithelial Cell Migration by Enhancing Epithelial Cell-Matrix (ECM) Interactions. Nationwide Children’s Hospital Research Poster Competition, Columbus, Ohio, April 18, 2012. Presented by Dr. Su.

233. Yang J and Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Protects the Intestines in Vivo by Inducing Mediators of Restitution During Experimental Necrotizing Enterocolitis. Nationwide Children’s Hospital Research Poster Competition, Columbus, Ohio, April 18, 2012. Presented by Dr. Yang.

234. Lutmer J, Chen C-L, Velton M, Zhang H-Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Attenuates Acute Lung Injury and Multi-Organ Dysfunction Following Scald Burn in Mice. Nationwide Children’s Hospital Research Poster Competition, Columbus, Ohio, April 18, 2012. Presented by Dr. Lutmer.

235. Watkins D, Chen C-L, Besner G: Heparin-binding EGF-Like Growth Factor (HB-EGF) Promotes Mesenchymal Stem Cells. Nationwide Children’s Hospital Research Poster Competition, Columbus, Ohio, April 18, 2012. Presented by Dr.Watkins.

236. Matthews M, Watkins D, Darbyshire A, Carson W, Besner G: HB-EGF Protects the Intestines from Radiation Therapy-Induced Intestinal Injury. Nationwide Children’s Hospital Research Poster Competition, Columbus, Ohio, April 18, 2012. Presented by Dr.Matthews.

237. Zhou Y, Yang J, Besner G: Neural Stem Cells Genetically Engineered to Overexpress HB-EGF Restore Intestinal Motility in Rat Pups Subjected to Necrotizing Enterocolitis. Annual Ohio State University Medical Center Research Day, Columbus, Ohio, April 19, 2012. Presented by Dr. Zhou.

238. Su, Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Promotes Intestinal Epithelial Cell Migration by Enhancing Epithelial Cell-Matrix (ECM) Interactions. Annual Ohio State University Medical Center Research Day, Columbus, Ohio, April 19, 2012. Presented by Dr. Su.

239. Yang J and Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Protects the Intestines in Vivo by Inducing Mediators of Restitution During Experimental Necrotizing

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Enterocolitis. Annual Ohio State University Medical Center Research Day, Columbus, Ohio, April 19, 2012. Presented by Dr. Yang.

240. Lutmer J, Chen C-L, Velton M, Zhang H-Y, Besner G: Heparin-binding EGF-like Growth Factor (HB-EGF) Attenuates Acute Lung Injury and Multi-Organ Dysfunction Following Scald Burn in Mice. Annual Ohio State University Medical Center Research Day, Columbus, Ohio, April 19, 2012. Presented by Dr. Lutmer.

241. Watkins D, Chen C-L, Besner G: Heparin-binding EGF-Like Growth Factor (HB-EGF) Promotes Mesenchymal Stem Cells. Annual Ohio State University Medical Center Research Day, Columbus, Ohio, April 19, 2012. Presented by Dr.Watkins.

242. Jakatdar A, Zhou Y, Besner G: Bone Marrow Dervied Mesenchymal Stem Cells can Differentiate into Neurons and Colonize Aganglionic Gut. Annual Ohio State University Medical Center Research Day, Columbus, Ohio, April 19, 2012. Presented by A. Jakatdar.

243. Bhushan B, Yang J, Besner G: The Effect of HB-EGF and Mesenchymal Stem Cells on Protection of the Intestines from Necrotizing Enterocolitis. Annual Ohio State University Medical Center Research Day, Columbus, Ohio, April 19, 2012. Presented by B. Bhushan.

244. Matthews M, Watkins D, Darbyshire A, Carson W, Besner G: HB-EGF Protects the Intestines from Radiation Therapy-Induced Intestinal Injury. Department of Surgery Resident Research Symposium, Ohio State University, Columbus Ohio, May 24, 2012. Read by Dr. Matthews.Winner – First Place Research Prize

245. Besner G: Electrical Burns. Advanced Burn Life Support Course, Columbus, Ohio, December 6, 2012. Read by Dr. Besner.

246. Besner G: Chemical Burns. Advanced Burn Life Support Course, Columbus, Ohio, December 6, 2012. Read by Dr. Besner.

247. Besner G: Transfer and Transport. Advanced Burn Life Support Course, Columbus, Ohio, December 6, 2012. Read by Dr. Besner.

248. Besner G: Distster Preparedness. Advanced Burn Life Support Course, Columbus, Ohio, December 6, 2012. Read by Dr. Besner.

249. Watkins D, Zhou Y, Yang J, Mathews M, Besner G: Heparin-Binding EGF-Like Growth Facor and Mesenchymal Stem Cells Act Synergistically to Attenuate Murine Intestinal Ischemia/Reperfusion Injury. Columbus Surgical Society Meeting, Columbus, Ohio, March 16, 2013. Read by Dr. Watkins.

250. Matthews M, Watkins D, Darbyshire A, Carson W, Besner G: HB-EGF Protects the Intestines from Radiation Therapy-Induced Intestinal Injury. Surgical Critical Care

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Visiting Professor Presentation, Nationwide Children’s Hospital, Columbus Ohio, March 19, 2013. Read by Dr. Matthews.

251. Watkins D, Zhou Y, Yang J, Mathews M, Besner G: Heparin-Binding EGF-Like Growth Facor and Mesenchymal Stem Cells Act Synergistically to Attenuate Murine Intestinal Ischemia/Reperfusion Injury. Surgical Critical Care Visiting Professor Presentation, Nationwide Children’s Hospital Columbus, Ohio, March 19, 2013. Read by Dr. Watkins.

252. Matthews M, Watkins D, Darbyshire A, Carson W, Besner G: HB-EGF Protects the Intestines from Radiation Therapy-Induced Intestinal Injury. Surgical Critical Care Visiting Professor Presentation, Nationwide Children’s Hospital Columbus, Ohio, March 19, 2013. Read by Dr. Matthews.

253. Brehm S, Zhou Y, Besner G: HB-EGF Knockout mice are Less Responsive to Neural Stem Cell Therapy for NEC-induced Intestinal Dysmotiliy. Ohio State University Trainee Research Day, Columbus, Ohio, April 11, 2013. Presented by S. Brehm.

254. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Intstinal Injury. Surgery Grand Rounds, Nationwide Children’s Hospital, Columbus, Ohio, May 22, 2013. Read by Dr. Besner.

255. Matthews M, Painter P, Besner G: The Protective Effect of HB-EGF in a Rat Model of Cerebral Palsy – a Pilot Study. Ohio State College of Medicine, Department of Surgery Research Conference, May 23, 2013. Read by Dr. Matthews.Winner – Second Place Research Prize

256. Watkins D, Matthews M, Zhou Y, Besner G: HB-EGF Augments the Ability of Mesenchymal Stem Cells to Attenuate Intestinal Injury. Ohio State College of Medicine, Department of Surgery Research Conference, May 23, 2013. Presented by Dr. Watkins.

267. Boomer L, Copper J, Deans K, Minneci P, Leonhart K, Diefenbah K, Kenney B, Besner G: Does Delay in Appendectomy affect Surgical Site Infection in Children with Appendicitis? Ohio State College of Medicine, Department of Surgery Research Conference, May 23, 2013. Presented by Dr. Boomer.

258. Wei J, Zhou Y, Besner G: Heparin-Binding EGF-like Growth Factor and Enteric Neural Stem Cell Transplantation Act Synergistically to Prevent Experimental Necrotizing Enterocolitis. Research Institute at Nationwide Children’s Hospital Annual Retreat, October 23, 2013. Read by Dr. Wei. Winner, Best Research Paper Award

259. Liu Y, Rager T, Painter P, Nelson T, Lannutti J, Besner G: HB-EGF Incorporation into Polyglycolic Acid (PGA) Scaffolds Enhances the Formation of Tissue Engineered Intestine. Research Institute at Nationwide Children’s Hospital Annual Retreat, October 23, 2013. Presented by Dr. Liu.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.260. Zhou Y, Besner G: Overexpression of HB-EGF Promotes Survival and Differentiation of

Enteric Neural Sem Cells after Transplantation into Mouse Dysganglionic Colon. Research Institute at Nationwide Children’s Hospital Annual Retreat, October 23, 2013. Presented by Dr. Zhou.

261. Besner G: Tips for Writing a Successful NIH Grant. Ohio State University Department of Surgery, Carrer Development Course for Surgeons Lecture Series, October 30, 2013. Read by Dr. Besner.

262. Besner G: Pediatric Burn Management. Advanced Burn Life Support Course, The Ohio State University, Columbus. Ohio, November 14, 2013. Read by Dr. Besner.

263. Besner G: Necrotizing Enteocolitis. Neonatology Grand Rounds, Nationwide Children’s Hospital, Columbus, Ohio, December 20, 2013. Read by Dr. Besner.

264. Besner G: Growth Factors and Stem Cells in Intestinal Injury. Gastroenterology Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio, January 30, 2014. Read by Dr. Besner.

265. Rager T, Liu Y, Lannutti J, Painter P, Nelson T, Besner G: Human Tissue Engineered Intestine Grown on a Bioabsorbable Polyglycolic Acid (PGA) Scaffold Infused with HB-EGF. Ohio State University Department of Surgery Research Day, Columbus, Ohio, May 15, 2014. Presented by Dr. Rager.Winner – First Place Poster Research Prize

266. Besner G: Tips for Writing a Successful NIH Grant. Ohio State University Department of Surgery, Carrer Development Course for Surgeons Lecture Series, June 12, 2014. Read by Dr. Besner.

267. Balint J and Besner G: Short Bowel Syndrome: Clinal and Research Challenges. Bench to Outcomes Seminar Sies (BOSS), The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, September 2, 2014. Read by Dr. Besner.

268. Liu Y, Rager T, Lannutti J, Johnson J, Painter P, Nelson T, Enmark J, Besner G: Enriched Intestinal Stem Cell Seeding Improves the Architecture of Tissue Engineered Intestine. The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, September 17, 2014. Read by Dr. Liu. Winner, Best Research Paper Award

269. Wei J and Besner G: HB-EGF Promotes M2 Macrophage Polarization and Protects the Intestines from Necrotizing Enterocolitis. The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, September 17, 2014. Presented by Dr. Wei.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.270. Rager T, Liu Y, Lannutti J, Painter P, Nelson T, Besner G: Human Tissue Engineered

Intestine Grown on a Bioabsorbable Polyglycolic Acid (PGA) Scaffold Infused with HB-EGF. The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, September 17, 2014. Presented by Dr. Rager.

271. Zhou Y, Wei J, Besner G: Neural Stem Cell-derived Exosomes Protect the Enteric Nervous System from Necrotizing Enterocolitis. The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, September 17, 2014. Presented by Dr. Zhou.

272. Besner G: Pediatric Burn Management. Advanced Burn Life Support Course, The Ohio State University, Columbus. Ohio, November 14, 2014. Read by Dr. Besner.

273. Besner G: Saving your NEC: Research Challenges and Opportunities. Alpha Epsilon Delta Pre-Med Honorary. Columbus, Ohio, April 1, 2015. Read by Dr. Besner.

274. Puttmann K, Zhou Y, Besner G: Development of Neural Tissue in Tissue Engineered Intestine. OSU College of Medicine Trainee Research Day, Columbus, Ohio, April 15, 2015. Presented by K. Puttmann.

275. Michalsky M, Cromeens B, Besner G: Intestinal Enteroids as a Potential Tissue Source for the Production of Tissue Engineered Intestine. Summer Student Poster Competition, Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, August 7, 2015. Presented by M. Michalsky.

276. Besner G: Separation of Ugandan Conjoined Twins Acen and Apio. Presentation to Nationwide Children’s Hospital Board of Trustees, Columbus, Ohio, September 25, 2015. Read by Dr. Besner.

277. Besner G: Pediatric Burn Management. Advanced Burn Life Support Course, Columbus. Ohio, October 15, 2015. Read by Dr. Besner.

278. Cromeens B, Liu Y, Stathopoulos J, Besner G: Intestinal Enteroid Culture: A Viable Solution to the Limited Tissue Source in the Production of Tissue Engineered Intestine (TEI). The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, November 17, 2015. Presented by Dr. Cromeens.

279. Olson J, Rager T, Navarro J, Mashburn-Warren L, Goodman S, Besner G: A Novel Method of Lactobacillus Delivery Prevents Experimental Necrotizing Enterocolitis. The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, November 17, 2015. Presented by Dr. Olson.

280. Liu Y, Rager T, Cromeens B, Johnson J, Chakroff J, Besner G: Comparison of Different in vivo Incubation Sites for Production of Tissue Engineered Intestine (TEI). The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, November 17, 2015. Presented by Dr. Liu.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.281. Zhou Y, Besner G: Exosomes Secreted by Neural Stem Cells Protect the Intestines from

Ischemia/Reperfusion Injury. The Research Institute at Nationwide Children’s Hospital Annual Research Retreat, Columbus, Ohio, November 17, 2015. Presented by Dr. Zhou.

282. Besner G: Tips for Writing a Successful NIH Grant. Ohio State University Department of Surgery, Career Development Course for Surgeons Lecture Series, Columbus, Ohio, November 30, 2015. Read by Dr. Besner.

283. Besner G: Necrotizing Enterocolitis. Pediatric Surgical Tutorial, Nationwide Children’s Hosital, Columbus, Ohio, December 16, 2015. Read by Dr. Besner.

284. Olson J, Rager T, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Probiotics that Produce Biofilms Have Increased Ability to Protect the Intestines from Necrotizing Enterocolitis. Columbus Surgical Society Meeting, Columbus, Ohio, February 27, 2016. Read by Dr. Olson. Winner – Platinum Research Prize

285. Cromeens B, Liu Y, Stathopoulos J, Wang Y, Johnson J, Besner G: Ex Vivo Enteroid Cultures Can Be Used To Produce Tissue Engineered Intestine (TEI). Columbus Surgical Society Meeting, Columbus, Ohio, February 27, 2016. Read by Dr. Cromeens. Winner – Bronze Research Prize

286. Olson J, Rager T, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Improving Probiotic Delivery to Protect Intestines from Experimental Necrotizing Enterocolitis. Critical Care Visiting Professor Lectureship Series, Columbus, Ohio, March 2, 2016. Read by Dr. Olson.

288. McCulloh C, Olson J, Zhou Y, Wang Y, Besner G: Reducing the Incodence and Severity of Necrotizing Enterocolitis Using Stem Cells: A Quantitative Analysis. Critical Care Visiting Professor Lectureship Series, Columbus, Ohio, March 2, 2016. Read by Dr. McCulloh.

289. Cromeens B, Liscandro R, Brilli R, Askegard-Guismann J, Kenney B, Besner G: Identifying Adverse Events In Pediatric Surgery: Comparing Morbidity & Mortality Conference to The National Surgical Quality Improvement Program – Pediatric (NSQIP-P) System. Critical Care Visiting Professor Lectureship Series, Columbus, Ohio, March 2, 2016. Read by Dr. Cromeens.

290. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Improving the Protective Effects of Lactobacillus reuteri Against Experimental Necrotizing Enterocolitis. Ohio State University Department of Surgery Research Day, Columbus, Ohio. June 3, 2016. Read by Dr. Olson.

291. Cromeens B, Liscandro R, Brilli R, Askegard-Giesmann J, Besner G: Comparing Morbidity & Mortality Conference to The National Surgical Quality Improvement Program – Pediatric (NSQIP-P) System at Identifying Adverse Events. Ohio State University Department of Surgery Research Day, Columbus, Ohio. June 3, 2016. Presented by Dr. Cromeens.

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292. McCulloh C, Olson J, Zhou Y, Wang Y, Besner G: Reducing Necrotizing Enterocolitis Incidence and Severity: A Quantitative Comparison of Different Stem Cell Types. Ohio State University Department of Surgery Research Day, Columbus, Ohio. June 3, 2016. Presented by Dr. McCulloh.

293. Gartner S, Olson J, McCulloh C, Besner G: Utilizing the Benefits of Biofilms: Prevention of Necrotizing Enterocolitis Using a Novel Probiotic Delivery System. Research Institute at Nationwide Children’s Hospital Research Forum, Columbus, OH, August 5, 2016. Presented by S. Gartner. First Place Medical Student Research Award (SG)

294. Manda D, Zhou Y, Besner G: Neural Stem Cell-derived Exosome Targeting of Injured Intestinal Neurons is Integrin Dependent. Research Institute at Nationwide Children’s Hospital Research Forum, Columbus, OH, August 5, 2016. Presented by D. Manda.

295. Vu J, McCulloh C, Olson J, Zhou Y, Wang Y, Besner G: Comparing the Effectiveness of Different Types of Stem Cells at Reducing the Incidence & Severity of Necrotizing Enterocolitis. Research Institute at Nationwide Children’s Hospital Research Forum, Columbus, OH, August 5, 2016. Presented by J. Vu.

296. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Goodman S, Besner G: Sucrose Promotes Lactobacillus reuteri Biofilm Production and Enhances Protection of the Intestines from Experimental Necrotizing Enterocolitis. Clatworthy Visiting Professor Research Presentation, Nationwide Children’s Hospital, Columbus, Ohio, October 3, 2016. Read by Dr. Olson.

297. McCulloh C, Olson J, Wang Y, Vu J, Gartner S, Besner G: Stem Cells and Necrotizing Enterocolitis: A Direct Comparison of the Efficacy of Multiple Types of Stem Cells. Clatworthy Visiting Professor Research Presentation, Nationwide Children’s Hospital, Columbus, Ohio, October 3, 2016. Read by Dr. McCulloh.

298. Manda D, Zhou Y, Besner G: Neural Stem Cell-derived Exosome Targeting of Injured Intestinal Neurons is Integrin Dependent. Northeast Ohio Medical University Medical Student Research Forum, Rootstown, OH, October 12, 2016. Presented by D. Manda.

299. Liu Y, Cromeens B, Wang Y, Chakroff J, Johnson J, Besner G: Comparison of Different Ages of Cell Donors for the Production of Tissue Engineered Intestine (TEI). The Research Institute at Nationwide Children’s Hospital, Annual Research Retreat, Columbus, Ohio, November 17, 2016. Presented by Dr. Liu.

300. Wang Y, Cromeens B, Liu Y, Johnson J, Besner G: Determination of Cellular Origin in Enteroid-Derived Tissue Engineered Intestine. The Research Institute at Nationwide Children’s Hospital, Annual Research Retreat, Columbus, Ohio, November 17, 2016. Read by Dr. Wang.Winner, Best Research Paper Award

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Curriculum VitaeGAIL ELLEN BESNER, M.D.301. Zhou Y, Olson J, McCulloh C, Besner G: Neural Stem Cell-derived Exosomes Protects

the Enteric Nervous System and Promotes Intestinal motility after Necrotizing Enterocolitis. The Research Institute at Nationwide Children’s Hospital, Annual Research Retreat, Columbus, Ohio, November 17, 2016. Presented by Dr. Zhou.

302. Olson J, McCulloh C, Navarro J, Mashburn-Warren L, Goodman S, Besner G: GtfW-Mediated Lactobacillus reuteri Biofilm Formation Reduces Intestinal Permeability and Enhances Protection Against Necrotizing Enterocolitis. The Research Institute at Nationwide Children’s Hospital, Annual Research Retreat, Columbus, Ohio, November 17, 2016. Presented byDr. Olson.

303. Varaljay V, Olson J, Navarro J, Mashburn-Warren L, Besner G, Bailey M, Goodman S: Persistence and the microbiome after a novel lactobacillus reuteri formulation treatment which prevents necrotizing enterocolitis. The Research Institute at Nationwide Children’s Hospital, Annual Research Retreat, Columbus, Ohio, November 17, 2016. Presented by Dr. Varaljay.

304. McCulloh C, Olson J, Wang Y, Vu J, Gartner S, Besner G: Evaluating the Efficacy of Different Types of Stem Cells in Preserving Gut Barrier Function in NEC. The Research Institute at Nationwide Children’s Hospital, Annual Research Retreat, Columbus, Ohio, November 17, 2016. Presented by Dr. McCulloh.

305. Nordin A, Sales S, Besner G, Levitt M, Wood R, Kenney B: Use of a Gastrointestinal Surgery Bundle Decreases Surgical Site Infections and Improves Outcomes. The Research Institute at Nationwide Children’s Hospital, Annual Research Retreat, Columbus, Ohio, November 17, 2016. Presented by Nordin.

305. Goodman S, Besner G: A Novel Probiotic Delivery Sysyem for Protection of the Intestines from Necrotozing Enterocolitis. Gastroenterology Research Seminar Series, Nationwide Children’s Hospital, Columbus, Ohio, December 1, 2016. Read by Dr. Besner.

306. Besner G: Novel Methods of Stem Cell Therapy and Probiotic Administration for NEC. Neonatology Research Seminar Series, Nationwide Children’s Hospital, Columbus, Ohio, December 7, 2016. Read by Dr. Besner.

307. Besner G: Stem Cell and Probiotic Therapy for Protection of the Intestines from Necrotozing Enterocolitis. Surgery Grand Rounds, The Ohio State University, Columbus, Ohio, December 2016. Read by Dr. Besner.

VISITING PROFESSORSHIPS (NATIONAL AND INTERNATIONAL)

1. Necrotizing Enterocolitis – From Bench to Bedside. Ulleval Hospital, Department of Pediatrics and Surgery, Oslo, Norway, June 3, 1998.

2. Necrotizing Enterocolitis – From Bench to Bedside. Norwegian Pediatric Association, Hammerfest, Norway, June 4, 1998.

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3. The Surgical Separation of Conjoined Twins, The James E. Allen Memorial Lectureship, Buffalo Children’s Hospital, Buffalo, NY, June 12, 2003.

4. HB-EGF and Protection of the Intestines from Injury. Tongji Hospital, Wuhan, China, June 2007.

5. HB-EGF and Protection of the Intestines from Injury. Children’s Hospital of Zhejiang, Zhejiang, China, June 2007.

6. HB-EGF and Protection of the Intestines from Injury. Children’s Hospital, Guangzhou, China, June 2007.

7. HB-EGF Therapy for Neonatal Necrotizing Enterocolitis – From Bench to Bedside. Toulukian Visiting Professorship, Yale Children’s Hospital, New Haven, CT, May 6, 2008.

8. The Surgical Separation of Conjoined Twins, Pediatric Surgery Grand Rounds, Yale Children’s Hospital, New Haven, CT, May 6, 2008.

9. HB-EGF Therapy for Intestinal Injury - Bringing Research Results to the Bedside. Surgical Grand Rounds, University of Wisconsin at Madison, December 4, 2011.

10. HB-EGF Therapy for Intestinal Injury - Bringing Research Results to the Bedside. Patricia C. Moynihan Women in Academic Surgery Lectureship, Visiting Professorship, East Tennessee State University, November 4, 2011.

11. Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Visiting Professor, Children’s Hospital of Philadelphia, Philadelphia, PA, February 28, 2013.

12. Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Ballantine Visiting Professor, Penn State Hershey Children’s Hospital, Hershey, PA, May 23, 2013.

13. Rounds at Zhejiang University Children’s Hospital, Hangzhou, China, July 11, 2013.

14. Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. International Symposium of Pediatric Hepatobiliary Disease, Tongji Hospital, Wuhan, China, July 13, 2013.

15. Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Department of Pediatric Surgery, Sichuan Provincial People’s Hospital, Chengdu, China, July 18, 2013.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.16. Research in the Etiology and Treatment of Necrotizing Enterocolitis.

Tongji Hospital, Wuhan, China, July 2013.

17. Necrotizing Enterocolitis: Research Challenges and Opportunities. Rush University, Chicago, IL, June 18, 2014.

18. Saving Your NEC: Research Challenges and Opportunities. Duke University, Durham, NC, September 30, 2015.

INVITED LECTURESHIPS

1. Besner G, Yang J, Watkins D, Zhou Y, Chen C-L: HB-EGF: Heparin-binding EGF-like Growth Factor (HB-EGF) to Prevent Necrotizing Enterocolitis. 52nd Annual Meeting of the European Society for Pediatric Research, New Castle, England, October 14, 2011. Invited Speaker. Read by Dr. Besner.

2. Besner G: HB-EGF Therapy for NEC. American Pediatric Surgical Association, San Antonio, TX, May 22, 2012. Invited Speaker. Read by Dr. Besner.

3. Besner G: HB-EGF Therapy for Necrotizing Enterocolitis. Annual Meeting of Pediatrics, Acapulco, Mexico, August 16, 2012. Invited Speaker. Read by Dr. Besner.

4. Besner G: Surgical Management of Necrotizing Enterocolitis. Annual Meeting of Pediatrics, Acapulco, Mexico, August 17, 2012. Invited Speaker. Read by Dr. Besner.

5. Besner G: Research in Etiology and Treatment for Necrotizing Enterocolitis. Necrotizing Enterocolits Symposium. Johns Hopkins University, Baltimore, MD. Invited Speaker. October 12, 2012. Read by Dr. Besner.

6. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Visiting Professor, Children’s Hospital of Philadelphia, Philadelphia, PA. Invited Speaker. February 28, 2013. Read by Dr. Besner.

7. Besner G: Research in the Etiology and Treatment of Necrotizing Enterocolitis. American Academy of Pediatrics District IX Section on Perinatal Pediatrics, California Association of Neonatologists Cool Topics in Neonatology Conference, Coronado, CA. Invited Speaker. March 2, 2013. Read by Dr. Besner.

8. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Ballantine Visiting Professor, Penn State Hershey Children’s Hospital, Hershey, PA. Invited Speaker. May 23, 2013. Read by Dr. Besner.

9. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. International Symposium of Pediatric Hepatobiliary Disease, Tongji Hospital, Wuhan, China. Invited Speaker. July 13, 2013. Read by Dr. Besner.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.10. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of

Necrotizing Enterocolitis. Department of Pediatric Surgery, Sichuan Provincial People’s Hospital, Chengdu, China. Invited Speaker. July 18, 2013. Read by Dr. Besner.

11. Besner G: A Pain in the NEC: Research Challenges and Opportunities. American Pediatric Surgical Association, Invited Speaker, Jay and Margie Grosfeld Lecture in Pediatric Surgery. Phoenix, AZ, May 30, 2014. Read by Dr. Besner.

12. Besner G: Novel Growth Factor and Stem Cell Therapies for the Treatment of Necrotizing Enterocolitis. Invited Speaker, William Gelfand Lecture, Phi Delta Epsilon Pre-Med Fraternity, University of Akron, Akron, OH, November, 2014.

13. Besner G: Novel Stem Cell and Probiotic Therapies for the Treatment of Necrotizing Enterocolitis. Invited Speaker, Cook Lecture, Department of Pediatric Surgery, Connecticut Children’s Medical Center, Hartford, CT, May 30, 2017.

INVITED PANALIST/MODERATOR

1. Invited discussant of paper entitled "New Modalities of Cancer Therapy: Anti-angiogenesis", The Columbus Surgical Society, Fourth Annual Presidential Symposium, Columbus, Ohio, January, 1993.

2. Invited discussant of paper entitled "Increased Growth of Pancreatic Carcinoma in Diabetes is Reversed by Insulin" by Dr. William Fisher et al., The Columbus Surgical Society, Fifth Annual Presidential Symposium, Columbus, Ohio, January, 1994.

3. Co-moderator of The First Annual H. William Clatworthy Oration, Columbus, Ohio, May 1993.

4. Invited participant in Inflammatory Response Mock Study Section, Young Surgical Investigators Conference, American College of Surgeons, Chantilly, VA, March, 1998.

5. Invited participant in Wound Healing/Inflammatory Response Mock Study Section, Young Surgical Investigators Conference, American College of Surgeons, Chantilly, VA, March, 2000.

6. Invited panel discussant, “Life as a Physician Scientist”, 3rd Annual Medical Scientist Student Forum, The Ohio State University College of Medicine, Columbus, Ohio, April 2000.

7. Moderator, Poster Session, American Academy of Pediatrics, Surgical Section, 2001 National Conference and Exhibition, San Francisco, California, October 20, 2001.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.8. Moderator, Poster Session, American Academy of Pediatrics, Surgical Section, 2002

National Conference and Exhibition, Boston, MA, October 20, 2002.

9. Moderator, Scientific Session, American Academy of Pediatrics, Surgical Section, 2002 National Conference and Exhibition, Boston, MA, October 21, 2002.

10. Moderator, Basic Science Mini-Symposium, Intestinal Barrier Function and Systemic Sepsis, American Academy of Pediatrics, Surgical Section, 2003 National Conference and Exhibition, New Orleans, LA, October 31, 2003

11. Invited participant in Wound Healing/Inflammatory Response Mock Study Section, Young Surgical Investigators Conference, American College of Surgeons, Chantilly, VA, March, 2004.

12. Invited discussant of paper entitled "Specific Tyrosine Residues of VE-Cadherin Mediate Endothelial Cell Migration: A Role in Angiogenesis", The American College of Surgeons Surgical Forum, New Orleans, LA, October, 2007.

13. Invited participant in Wound Healing/Inflammatory Response Mock Study Section, Young Surgical Investigators Conference, American College of Surgeons, Bethesda, MS, March, 2008.

14. Moderator, Pediatric Surgery Surgical Forum Session, The American College of Surgeons Surgical Forum, San Francisco, CA, October, 2008.

15. Invited discussant of paper entitled “Mesoscopic Traffic Flow Analysis of Platelet dynamics in Chemically-Induced Murine Colitis”, The American College of Surgeons Surgical Forum, Chicago, IL, October, 2009.

16. Invited participant in Wound Healing/Inflammatory Response Mock Study Section, Young Surgical Investigators Conference, American College of Surgeons, Bethesda, MD, March, 2010.

17. Moderator, Basic Science Session, The American Pediatric Surgery Association, Orlando, FL, May, 2010.

18. Invited VIP Panelist, Nationwide Children’s Hospital Telethon, June 5, 2010.

19. Co-Moderator, International NEC Webcast, hosted by Rainbow Babies Hospital and Nationwide Children’s Hospital, June 17, 2010.



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Curriculum VitaeGAIL ELLEN BESNER, M.D.22. Invited Panelist, Johns Hopkins Medical School, 2nd Annual Updates and Advances in

Neonatal Neurological Care for the Practitioner, Surgical Management of NEC: Pro/Con Debate, October 11, 2012.

23. Co-Moderator, American College of Surgeons Panel Session, At the Tipping Point: A Decade of High Impact Research from Jacobson Promising Investigator Awardees, San Francisco, CA, October 30, 2014.

24. Panelist, Career Development, Pediatric Surgery Residents Conference, American Academy of Pediatrics National Conference and Exhibition, Chicago, IL, October 23, 2015.

25. Chair, Regenerative Medicine Session, T2C Meeting, Center for Regenerative Mecicine and Cell Based Therapies, Columbus, Ohio, March 18, 2016.

26. Panelist, Physican Leadership Careers, Fellow Core Curriculum Lecture Series, Nationwide Children’s Hospital, Columbus, Ohio

27. Panelist, Laboratory Models of NEC, SIGNEC U.K. (Special Interest Group NEC U.K.), London, England, September 26, 2016.

28. Moderator, Stem Cell Therapy for NEC, NEC Symposium: A Transdisciplinary Approach to Improved NEC Outcomes, Sacramento CA, April 6, 2016.

ADDITIONAL EDUCATIONAL ACTIVITIES

1. Member of Organizing Committee, Wound Healing, Oxygen and Emerging Therapeutics Meeting, September 12-15, 2002, Columbus, Ohio.

2. Physician Panelist in the Accelerated Summer Science Program for High School Students Interested in Medicine and Medical Research, Mechanisms of Human Health and Disease, Nationwide Children’s Hospital, Columbus, Ohio, July 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016.

3. Participant in Dinner with Docs mentoring program of Alpha Epsilon Delta Medical Society, Ohio State University, Columbus, Ohio, April 7, 2014.

4. Participant in Dinner with Docs mentoring program of Alpha Epsilon Delta Medical Society, Ohio State University, Columbus, Ohio, April 1, 2015.

HIGH SCHOOL STUDENT SHADOWING

1. Participant in Licking County High School's Student Mentorship Program, Student -Michelle Dennis, April 10,11,17, 1995.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.2. Advisor to the Dublin High School's Young Professionals' Academy Program entitled "Pre-

Professional Business Management and Professional Internship Program", student - Kim Cooper, 4/22/96-5/24/96.

3. Participant in Worthington High School Shadowing Day, Student - Lindsey Pinyerd, April 7, 1997.

4. Participant in Marion-Franklin High School Internship Mentoring Program, student – Sandra Fraley, 3/3/99-5/15/99.

5. Participant in Student Shadowing Program, Mechanisms of Human Health and Disease Program, organizer: Joe Schultz, Process Consultant, Business Process Improvement Center, Nationwide Children’s Hospital). Participants – Emily Flower (Ohio Virtual Academy), January 18, 2010.

6. Shadowing Mentor – Srija Reddy, Columbus School for Girls, July 2014.

7. Shadowing Mentor – Noa Levi, Columbus School for Girls, pre-med student, November 11, 2014.

8. Shadowing Mentor – Himaja Reddy, Columbus Academy, pre-med student, 2014.

9. Shadowing Mentor – Akash Paladugu, Columbus Academy, pre-med student, 2014.

10. Shadowing Mentor – Riley Ransom, Columbus Academy Senior Project, May, 2015.

11. Shadowing Mentor – Alexis Juergenson, SEARCH Student, 2015.

12. Shadowing Mentor – Alexis Juergenson, 2016.

COLLEGE STUDENT SHADOWING

1. Shadowing Mentor – Lucy Chen, Junior Undergraduate Student, Washington University, St. Louis, January 8, 11, 2007.

2. Shadowing Mentor – Yamini Jadcherla, Junior Undergraduate Student, Washington University, St. Louis, June 5, 6, 2011.

3. Shadowing Mentor - Aaron Moore, Wittenberg University Shadowing Program, Springfield, Ohio, February-May, 2012.

4. Shadowing Mentor – Erin Messerly, Ohio Dominican University, pre-med student, November 18, 2014.

5. Shadowing Mentor – Alexandria Speakman, The Ohio State University, pre-med student, 2014.

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Curriculum VitaeGAIL ELLEN BESNER, M.D.6. Shadowing Mentor – Kathleen Puttmann, The Ohio State University, pre-med student,

2014.

7. Shadowing Mentor – Kendra Poston, University of Concinnati, pre-med student, 2015.

8. Shadowing Mentor – Hannah Kayuha, The Ohio State University, 2015.

9. Shadowing Mentor – Ana Sucaldito, Ohio State University, pre-med student, February and March, 2015.

10. Shadowing Mentor – Julia Dubai, Ohio State University, pre-med student, February, 2015.

11. Shadowing Mentor – Lirsten Boes, Ohio State University, pre-med student, 2015.

12. Shadowing Mentor – Kyle Schmitz, Ohio State University, pre-med student, 2015.

13. Shadowing Mentor – Laura Sooy, Ohio State University, pre-med student, 2015.

14. Shadowing Mentor – Sarah Gartner, Ohio State University, pre-med student, 2015.

15. Shadowing Mentor – Natalie Huigreste, Ohio State University, pre-med student, 2015.

16. Shadowing Mentor – Gaby Perez, Miami University, pre-med student, 2015.

17. Shadowing Mentor – Joel Salas, Ohio State University, pre-med student, 2015.

18. Shadowing Mentor – Ian Sunyecz, Ohio State University, pre-med student, 2015.

19. Shadowing Mentor – Tiffany Noel, Ohio State University, pre-med student, 2015.

20. Shadowing Mentor - Nicole Brigstock, University of Pennsylvania, 2016.

21. Shadowing Mentor – Julia Love, Ohio State University, pre-med student, 2016.

22. Shadowing Mentor – Mackenzie Fuller, Bowling Green State University, pre-med student, 2016.

23. Shadowing Mentor – Catherine Fabian, Ohio State University, pre-med student, 2016.

24. Shadowing Mentor – Morgan Morrison, Ohio State University, pre-med student, Sept 19-20, 2016.

MEDICAL SCHOOL STUDENT SHADOWING

1. Shadowing Mentor – Arthur Siebesian, Ohio State University College of Medicine, 2015.

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2. Shadowing Mentor - Graziella Siebesian, Ohio State University College of Medicine, 2015.

3. Shadowing Mentor – Kelli Fisher, Ohio State University College of Medicine, 2015.

ADDITIONAL ACCOMPLISHMENTS

1. In the past several years Dr. Besner has been the lead surgeon for the successful separation of three sets of conjoined twins at Nationwide Children’s Hospital. The first set of twins (pygopagus) was referred to Dr. Besner from Liberia, Africa, the second set (thoraco-omphalopagus) from Central Ohio, and the third set (pygopagus) from Uganda, Africa. The publicity for the hospital resulting from the first two operations led to advertising equivalency of over $4,500,000, reaching 342 million viewers (including Dateline NBC, Connie Chung Tonight, Good Morning America, American Morning with Paula Zhan) and over 11 million readers.

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CURRICULUM VITAE - Ohio State University · Web view1)International Web Course on Necrotizing...

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