Central

dogma of

genetic

information

The importance

in medicine

There are a lot of things that

make important the dogma; in

this case we could see that

there are some things that

have a different way to make

their process, and that is

crucial in the moment to study

these for can fight them.

So, in the world we have a lot

of organism that can help us,

but there are to a lot that

harms us, and these are the

things that we must see and

must remember always that

begin to think in the different

way to save the humanity of

that problems.

We can conclude that if we

must go ahead, we must be

really fast and smart and we

need to recognize a lot of

variable that we find in the

nature for can be able to fight

the problems that we find.

BIBLIOGRAPHY

American Society for Microbiology. (2015,

January 20). Genetic changes in Ebola

virus in West African outbreak could hinder

potential treatments.ScienceDaily.

Retrieved January 29, 2015 from

www.sciencedaily.com/releases/2015/01/1

50120102458.htm

International School of Advanced Studies

(SISSA). (2015, January 6). Tight packing

in shell leaves viruses

vulnerable.ScienceDaily. Retrieved

January 29, 2015 from

www.sciencedaily.com/

Martínez Sánchez, Lina María; Vargas

Grisales, Natalia; Toro Montoya, Andrés

Eduardo; Pamplona Sierra, Ana Paulina;

Queveda Orrego, Esteban. “Biología

molecular”. 7. ed. Medellín, Colombia.

Editorial Universidad Pontificia Bolivariana,

2014. pp: 74-77

BY

SEBASTIÁN VERA HENAO

INTRODUCTION

We know that DNA is located in the

nucleus, but not all the actions are

performed there. Therefore, must be

an intermediary that helps the DNA in

the transport of the information from

the nucleus to cytoplasm.

The intermediary is the RNA that

allows to carry it to the cytoplasm for

begin with the synthesis of proteins.

The procedure in that the RNA allows

the protein's synthesis is the genetic

code, which is organized of a way

where three nucleotides can do an

aminoacid.

But there are cases when some kinds

of organism don´t have the same way

to do this process, like the virus,

retrovirus and prions.

Título que describe la imagen o

el gráfico

Tight packing in shell leaves

viruses vulnerable

In the study, makes the search of the way that

the shell where is the virus information, can

suffer a modification, discovering that there

are some ways that can make this organism

vulnerable; an organism with a different

process to replicate their information and of

subsistence.

For the study, they worked with virus that had

RNA, where we could read that their

information is really packed and must be

addition "combed" , before to be in its shell.

With this information, watching some changes,

they noticed that there are mechanisms that

could make bigger the mass of the RNA, and if

it expands, this could avoid the virus

replication.

So, there are two significate things in the

virus, one is who determinate their infection

potential, and the other their protein

production. These things, make that people

ask their selves what is the necessary level of

mutation in the second determinant to

interfere with the packed.

For can understand this, also, one should know

that the virus differ a lot with other organisms,

specially in the replication process; because they

don´t comply with the normal dogma, and they

need “hijack” a cell for it begins their replication

process and obtain of this way new virus.

I think that to know the way that the virus replicates and the way to stop this, is one of the biggest discoveries that the human could do; for that I think that this class of news, are really needed in the daily life for feed the mind of the people that is looking for fight with these organisms.

Genetic changes in Ebola virus

in West African outbreak could

hinder potential treatments

Have been made some studies where looking

for how the Ebola virus have change in the

last four decades, this with the final motive of

finding out different problems that can pop up

at time of the fabrication of the medicament

for the fight with it.

The virus, with the time that has and with the

step of one organism to other, have achieved

design some kinds of genetic modifications,

which make an inconvenient at time to fight

with the virus, because when the people

make a new effective medicament with effect

counter the Ebola, its mutations, can be so

big that there isn´t effect counter the white

point that thought fight with the medicament.

Even, can have medicaments that before to

hit the market of an official way, begins to

down its effectiveness and this was the thing

that treated to find in the search of virus

changes. They were looking for to know what

were the changes, and avoid that

pharmaceuticals begin with studies and

works in medicaments without effectiveness

With this, they conclude with the surpirise

that can be the virus for us, and how their

mutation power is so fast and can to generate

drawbacks in our medicine.

I really think that this kind of news are really important, not only in medicine but in the life because the information about a disease so common the last days, people should be aware of the advances. And obviously, can be really delicate the part of study the group of changes that has a virus like Ebola, for can eradicate it and save the humanity of them.

INTRODUCTION

The DNA is localized in the nucleus, but not all the

actions are made there, and for that is that the cell

needs conveyor that arrives the DNA information to the

cytoplasm.

The conveyor is the RNA, who has 3 forms,

Messenger, ribosomal and transference.

With the 3 forms of this, the information that is in the

DNA can go to cytoplasm for turn in proteins.

But there are some things that doesn´t have the same dogma that the most of the

cells, and these are the retrovirus and prions, who have different way to make

the transport or information.

NEWSGenetic changes in Ebola virus in West African outbreak could hinderpotential treatments

The study, was searching some

changes that have been the Ebola in

the last four decades

They did this, with one motive, that was finding out

different problems that pop

At time to create the medicaments that fight with the

virus.

NEWS

The virus with time and step of one organism to other, begins to create

some modifications

These modifications, make really difficult the

creation of medicaments

That´s because whenthey create one

They had changed thewhite point where weregoing to work the active

principle

NEWS

•Even, can have medicaments that before to hit the

market of an official way, begins to down its

effectiveness and this was the thing that treated to

find in the search of virus changes. They were

looking for to know what were the changes, and

avoid that pharmaceuticals begin with studies and

works in medicaments without effectiveness

NEWS

• With this, they conclude with the

surprise that can be the virus for us,

and how their mutation power is so

fast and can to generate drawbacks

in our medicine.

PERSONAL COMMENT

I really think that this kind of news are really important, not only in medicine but in the life, because the information about a disease so common the last days, people should be aware of the advances. And obviously, can be really delicate the part of study the group of changes that has a virus like Ebola, for

can eradicate it and save the humanity of them.

NEWSTight packing in shell leaves viruses vulnerable

In the study, makes the search that the shell with the virus information, could

suffer modifications.

They discovered some ways to make

this organism vulnerable

And is obligatory remembering that this is an organism with a different way to replicate and of

subsistence.

NEWS They worked with virus that had the information in RNA

They could see that their information is really packed and must be addition "combed" , before to be in its

shell.

At the end, the saw that there a mechanism where the RNA expands it and begins to have a bigger mass

This makes that the replication of the virus can´t do it.

NEWS

So, there are two significate things in the virus,

one is who determinate their infection potential,

and the other their protein production. These

things, make that people ask their selves what

is the necessary level of mutation in the second

determinant to interfere with the packed.

NEWSFor can understand all this we need to know that the virus are different. They has a specially way to replication.

Also they have a different process in the dogma

And finally we must recognize that they for can live, must “hijack” a cell and make that these replicate him information.

PERSONAL COMMENT

I think that to know the way that the virus replicates and the way to stop this, is one of the biggest discoveries that the human could do; for that I think that this class of news, are

really needed in the daily life for feed the mind of the people that is looking for fight with these organisms.

MEDICAL UTILITY

There are a lot of things that make important the dogma; in this case we could see that there are some things that have a different way to make their process, and that is crucial in the moment to study these for can fight them.

MEDICAL UTILITY

So, in the world we have a lot of organism that can help us, but there are to a lot that harms us, and these are the things that we must see and must remember always that begin to think in the different way to save the humanity of that problems.

MEDICAL UTILITY

Is necessary to recognize the differences that present the nature, for

recognize the problems that we can see in these.

MEDICAL UTILITY

We can conclude that if we must go ahead, we must be really fast and smart and we need recognize a lot of variable that we find in the nature for can be able to fight the problems that we find.

BIBLIOGRAPHY• AMERICAN SOCIETY FOR MICROBIOLOGY. (2015, JANUARY 20).

GENETIC CHANGES IN EBOLA VIRUS IN WEST AFRICAN OUTBREAK COULD HINDER POTENTIAL TREATMENTS.SCIENCEDAILY. RETRIEVED JANUARY 29, 2015 FROM WWW.SCIENCEDAILY.COM/RELEASES/2015/01/150120102458.HTM

• INTERNATIONAL SCHOOL OF ADVANCED STUDIES (SISSA). (2015, JANUARY 6). TIGHT PACKING IN SHELL LEAVES VIRUSES VULNERABLE.SCIENCEDAILY. RETRIEVED JANUARY 29, 2015 FROM WWW.SCIENCEDAILY.COM/

• MARTÍNEZ SÁNCHEZ, LINA MARÍA; VARGAS GRISALES, NATALIA; TORO MONTOYA, ANDRÉS EDUARDO; PAMPLONA SIERRA, ANA PAULINA; QUEVEDA ORREGO, ESTEBAN. “BIOLOGÍA MOLECULAR”. 7. ED. MEDELLÍN, COLOMBIA. EDITORIAL UNIVERSIDAD PONTIFICIA BOLIVARIANA, 2014. PP: 74-77