C905-0l/ll THE RAT OOIVIIXIAL SUPPLEMENT …'i\c905-0l/ll perchlordethylene: mjjltigeneration...

$: C905-0l/ll THE RAT OOIVIIXIAL SUPPLEMENT …'i\c905-0l/ll perchlordethylene: mjjltigeneration inht\lation stijdy lli the rat ooiviixial .t\nimal th\ta supplement appendix 26b$
J:'i\C905-0l/ll

PERCHLORDETHYLENE: MJJLTIGENERATION INHt\LATION STIJDY lli THE RAT OOIVIIXIAL .t\NIMAL Th\TA SUPPLEMENT

APPENDIX 26B

PATI!OI.,CX;y - F2B PUPSGROUP: l IXJSE: 0 Pfill

PUP ID: 30/A SEX: M ON STIIDY: 1 day (1 wk) INT EVC

MACRDPATIJQI.,CX;y

THE l'OLLOWIN::; MACRDSOOPIC OBSERVATIONS WERE MADE HEAD(EVl : Head appears to have been squashed.

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ("')-1,.........."0...... 0""'......

.....'""

'""

c.n0>

P!IC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

lNDIVIIXJAL ANlMAL DATA SUPPLEMENT

APPENDlX 26B

GROUP: LI'lTER:

1 31

OOSE: 0 ppn PATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE IAD

("") -l.........., ...... ""' 0 \0 .....

..... \0 t.J1 .....

-~

A B c D E F

F F F F M M

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

26/04/93 26/04/93 26/04/93 26/04/9326/04/93 26/04/93

'--..--' ~

rAC905-0l/ll

PERCHLOROETHYLENE: MULTIGENERATION lNHAlATION STUDY IN TilE RAT INDIVIIXIAL AN1MI\L 11>\TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 1 IXlSE: 0 ppn

LI'ITER: 32

LITTER SUMMARY PUP SEX BODY CLIN FATE DATE P.M. DATE IADID wr OBS

A F DISCi\RDED 24/04/93B M DISCi\RDED 24/04/93c F DISCARDED 24/04/93 D F DISCi\RDED 24/04/93E M DISCARDED 24/04/93F F DISCi\RDED 24/04/93G M DISCARDED 24/04/93H M DISCi\RDED 24/04/93I F DISCi\RDED 24/04/93J F DISCARDED 24/04/93

("") -i ,-...... .., ...... 0 ""' ...., "'

....."'01CXl

PIIC905-0l/ll

GROUP: LITTER:

1 34

roSE:

PERCHLORDETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL .ANlMAL Jl.\TA SUPPI..I'MENT

APPENDIX 26B

PATHOLOOY - F2.B PUPS0 ppn

"............. "0 ....... ""' 0 \0 .....

...... \0 t.n 1.0

PUP ID

A B c D E F G H I J K L M N 0 p Q

SEX

F M F M F M F M F F F F M F M M M

BODY wr

5.7

CLIN OBS

ABN ABN

LITTER SUMMARY

FATE DATE P.M.

INT EVC 20/04/93 NAD INT EVC 20/04/93 ABNDISCARDED 24/04/93DISCAROEO 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCAROEO 24/04/93DISCAROEO 24/04/93DISCARDED 24/04/93DISCAROEO 24/04/93DISCAROEO 24/04/93DISCARDED 24/04/93DISCAROEO 24/04/93DISCAROEO 24/04/93DISCARDED 24/04/93

DATE

20/04/9320/04/93

IliD

*

-------------------------------------------------------END OF PUP------------------------------------------------------------------

~

\.__.·

P.AC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INOIVIJXlAL ANlMAL n\TA SUPPLEMENT

APPENDlX 26B

PATHOLOGY - F2B PUPSGROUP: 1 OOSE: 0 Pfill

PUP ID: 34/B SEX: M ON STUDY: 1 day (1 wkl INT EVC

MACROPATHOLOGY

THE FQil.(JiillX; MACROSCOPIC OBSERVATIONS WERE MADE

LIMB : Both hind l:lmbs and front right forelimb missing.TAIL ' Tail missing.

-------------------------------------------------------END OF PUP------------------------------------------------------------------

~ -; ~

~ " C) co 'J

...... co 01 C)

PAC905-0l/ll

GROUP: LITI'ER:

1 35

IXJSE:

PERCHLORDETIIYLENE: MULTIGENERATION INHA!.ATION STUDY IN THE RAT

INDIVIJJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PA1'l!OLOGY - F2B PUPS 0 PJl1l

(") ....; r ...... "0 ........,. 0

'""...,

.... '"" "' ....

PUP ID

A B c D E F G H I J K L M

SEX

M F F M F F M M M M F F M

BODY wr

CLIN OBS

LITTER SUMMARY

FATE DATE P.M.

DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93

DATE IAD

'--'

P!IC905-0l/ll

PERCHLOROEI'HYLENE: MJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANlMI\1 DAXA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 1 OOSE: 0 P!IIlLI'ITER: 36

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IADID wr OBS

A M DISCARDED 20/05/93B M DISCARDED 20/05)93c M DISCARDED 20/05/93 D F DISCARDED 20/05/93E M DISCARDED 20/05/93F M DISCARDED 20/05/93G F DISCARDED 20/05/93H F DISCARDED 20/05/93I M DISCARDED 20/05/93J F DISCARDED 20!05/93K M DISCARDED 20/05/93L F DISCARDED 20/05/93M F DISCARDED 20/05/93N M DISCARDED 20)05/93 0 F DISCARDED 20/05/93p F DISCARDED 20/05/93

(") -I

-...."'0 -....,. 0

...... ""

...... 0"> "" ""

--··--·- ··---·------

PAC905-0l/ll

PERCHLORDETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXJAL ANlMAL DATA SUPPLEMENT

GROUP: LITI'ER:

1 37

DOSE: 0 ppn

APPENDIX 26B

PATHOLOGY - F2B PUPS

" -1....... '"0 .......,. 0 <0....,

..... <0 0'> w

PUP ID

A B c D E

SEX

F M M F F

BODY wr

CLIN OBS

LITTER SUMMARY

FATE ~ P.M.

DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93

~ lAD

,_

J:'AC905-0l/ll

GROUP: LIT'IER:

1 38

OOSE:

PERC!JLOROETHYLENE: MIJLTIGENERATION INHALIITION S'IUDY IN THE RAT

INDIVIDUAL ANIMAL Ili\TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS 0 ppn

("') -i r...... "'C .......,. 0

"' ......

..... "'0'\.,.

PUP ID

A B c D E F ~ ~

H I J K L M

SEX

M F M F M F F M M F F F F

BODY wr

CLIN OBS

LITTER SUMMARY

Fl\l'E llA.TE P.M.

DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCl\ROED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24)04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93

llA.TE IAD

PAC905-0l/ll

GROUP: LITIER:

1 39

OOSE:

PERC!ILOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL .ANlMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS0 ppn

n -ir ......'"'0 ......""'0

""....,

..... "" 0'1 U1

PUP ID

A B c D E F G H

SEX

M F M M F F F M

BODY wr

CLIN OBS

LITTER SUMMARY

FATE DATE P.M.

DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93DISCARDED 24/04/93

DATE IAD

~ "---'

.-AC905-0l/ll

PEBCHLOBDETHYLENE: MIJLTIGENERATION lNHAI..ATION STUDY IN THE RAT

INDIVIIXTAL ANIMAL IliiTA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 1 IXISE: 0 ppn

LITTER: 40

LITTER SUMMARY PUP SEX BODY CLIN FATE Il'ITE P.M. Il'ITE IADID wr OBS

A F DISCi\RDED 26/04/93B M DISCARDED 26/04/93c F DISCARDED 26/04/93 D F DISCARDED 26/04/93E F DISCARDED 26/04/93F F DISCARDED 26/04/93G M DISCi\RDED 26/04/93H F DISCARDED 26/04/93I F DISCARDED 26/04/93J F DISCARDED 26/04/93K M DISCi\RDED 26/04/93

n -i r-...... ., ...... .., 0 \0 ..... I

......\00'10'1

--

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVI!JIJAL AN.IMAL ll'ITA SUPPLEMENT

APPENDIX 26B

GROUP: LITTER:

1 41

rosE: 0 ppn PATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE Il\D

A B c D EF GHI J

M M M M F F F F F F

6.4 6.4 6.1 6.2 5.8 6,0

ABN ABN ABN ABN ABN ABN ABN

INT EVC INT EVC INT EVC INT EVC INT EVC INT EVC INT EVC LOST LOST LOST

22/04/93 22/04/93 22/04/93 22/04/93 22/04/93 22/04/93 22/04/93 24/04/9324/04/9324/04/93

ABN ABN ABN ABN ABN ABN ABN

22/04/93 22/04/93 22/04/93 22/04/93 22/04/93 22/04/93 22/04/93

* * * * * * *

("') .....,......_ "0..._ ... "" 0

.....

..... ""O'l .....

~· '-'

PAC905-0l/11

PERCHLOROIITHYLENE: MDLTIGENERATION INHAU.TION STUDY IN TilE RAT

INDIVIDUAL ANlMAL Jl.\TA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPS GROUP: 1 IXJSE: 0 P!E

PUP ID: 41/A SEX: M ON STUDY: 1 day (1 w) INT EVC

MACROPATHOLCGY GENERAL AUTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------("") ............ "'C ........, 0 ....., '""

..... '"" OJ"'

"-i,... -., -., 0

...... '"'

-'"' "' '"'

PJ\C905-0l/ll

PERCHLOROErHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDJAL ANIMAL Il.'\TA SlJPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP:

PUP ID: 1 !XlSE:

41/B 0

SEK: M ppn

ON STUDY: 1 day (1 \01<:) INT EVC

MACROP.ATHOLOGY

GENERAL AIJTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

,-, '~

'-...-'·----·

PAC905-01/ll

PERQJI.OROEI'HYLENE: MULTIGENERATION JNHALATION STUDY ill THE RAT

INIJIIliOOliL AN1M8L D!ITA Sl.lPPl.J;MEN'1

APPENDIX 26B

GROUP: PATilOLCGY -

1 F2B PUPS

PUP ID: 41/C DJSE: SEX: 0 M ppn

ON STUDY: 1 day (1 wkl INT EVC

WICRDPATilOLCGY GENERAL AUTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

.(")

-<.......,...... 0.., .....,"'

....."'0......

"--l, ...... -o .......,. 0 lO....

..... lO....., .....

PAC905-01/ll

PERCHLORDE'l'!IYLENE: MOLT!GENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL 1INlMIIL 1:>\TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 1

PUP OOSE:

ID: 41/D 0 ppn

SEX: M ON STUDY: 1 day (1 wk} INT EVC

Mi\CRDPATHOLOGY GENERAL AUTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

~-

'-.--'-

rAC905-01/ll

PERCHLO!lDETHYLENE: !fi.TIGENERATION lliHAL/ITION STUDY IN TilE RAT

INDIVIIX!AL ANIMAL !lATA SUPPLEMENT

APPENDIX 26B

PATHOLOOY - F2B PUPSPUP ID:

GROUP: 1 41/E

OOSE: SEX:

0 F

ppnON STUDY: 1 day (1 ~l INT EVC

MACROPATHOLOOY GENERAL llll'IOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------("")

'-;

........,

........,.0....,""

....

......""N

("") -f

......., r

.......,. 0 1.0 .....

...... 1.0....., w

PAC905-01/ll

PERCHLORDEI'HYLENE: MIJLTIGENERATION lNHALATION STUDY IN THE RAT

INDIVIDUAL .ANlMAL Jl.\TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS PUP ID:

GROUP: 141/F

IXlSE: 0SEX: F

ppn ON STUDY: 1 day (1 'M<) INT EVC

MACROPATHOLOGY GENERAL AIJTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

--~, ~.

·-----· ~·

PAC905-01/ll

PERCHLORDETIIYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANJMAL ll\TA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPS GROUP: 1 rosE: o ppn

PUP ID: 41/G SEX: F ON STUDY: 1 day (1 ~) INT EVC

MACROPATHOLCGY Found dead, camibalised. Internal organs missing.

00 ABOOBM!\.LITIES WERE SEEN IN THE ANJMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------("'") -; ,... ...... -o ........,. 0

.....

......

"'

..... "' ..,.

--·~--·--------------------·- ···-·

PAC905-0l/ll

PERCHLOROET!IYLENE: M!JLTIGENERATION INIIALATION STUDY IN THE RAT

INDIVIIJUAL IINlMAL DATA SUPPLEMENT

APPENDIX 26B

GROUP: LI'ITER:

1 42

IOSE: 0 ppn PATIIOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. Illl.TE TAD

("") -l ........._.,...._ ""'0

"" ......

1-'

"" ....., tJ1

A B c D E F G

F M F M F M M

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

24/04/9324/04/9324/04/9324/04/9324/04/93 24/04/9324/04/93

~.'~

·J '---'

PAC905-0l/ll

PERCHLORDE'IHYLENE: l«.TIG'I!:NERATION INHALATION STUDY IN THE RAT

INDI\IIOOAL ANlMi\L DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 1 OOSE: 0 Jlll1lLUTER: 43

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE TADID wr OBS

A M DISCARDED 24/04/93B F DISCARDED 24/04/93c F DISCARDED 24/04/93D M DISCARDED 24/04/93E M DISCARDED 24/04/93F M DISCARDED 24/04/93G M DISCARDED 24/04/93H M DISCARDED 24/04/93I M DISCARDED 24/04/93J F DISCIIRIJED 24/04/93K F DISCARDED 24/04/93

"-i -...--c -.. ..,. 0

...... '"' '

.....'"'......"'

PAC905-0l/ll

GROUP: LITTER:

1 44

OOSE:

PERCHLOROETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANIMAL IlA:rA SUPPLEMENT

.APPENDIX 26B


(") ....; r-"'0 -..,. 0 <.0...., I

.... <.0....,....,

PUP ID

A B c D E F G H I J K

SEX

F M F M F M M F F F F

BODY wr

CLIN OBS

LITTER SUMMARY

FATE DATE P.M.

DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93

DATE IAD

~·

··J:'AC905-01/ll

PEBCHLOROE'I'HYLENE: MIJLTIGENERATION INHt\11\TION STUDY IN THE RAT

INDIV:I:ru\L ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PAT!!OLOOY - F2B PUPSGROUP: 1 DJSE: 0 PfillLITTER: 45

LITTER SUMMARY PUP SEX BODY CLIN FATE DATE P.M. DATE Il\lJID wr OBS

A F DISCARDED 29/04/93B M DISCARDED 29/04/93c M DISCARDED 29/04/93D M DISCARDED 29/04/93E F DISCARDED 29/04/93F M DISCARDED 29/04/93G M DISCARDED 29/04/93H M DISCARDED 29/04/93I M DISCARDED 29/04/93J F DISCARDED 29/04/93K M DISCARDED 29/04/93L M DISCARDED 29/04/93M F DISCARDED 29/04/93

'"'..... r-......., ......... 0 ..., ""

,_.....,""CXl

PAC905-0l/ll

PERC!lLORDETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL .AN1MI\L DATA SUPPLEMENT

APPENDIX 26B

GROUP: LITI'ER:

1 46

OOSE: 0 Plill PATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP 1D

SEX BODY WI'

CLIN OBS

FATE DATE P.M. DATE lAD

("") -i ;...... "'0 ...... ""'0

"" .....,

..... "" ....., ""

A B c D E F G

M M M M F F F

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED LOST LOST

20/05/93 20/05/9320/05/93 20/05/9320/05/93 2.0/05/932.0/05/93

\ ...~

.t'AC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION lNHALII1'ION STUDY IN THE RAT

INDIVIlXIAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPSGROUP: 1 lOSE: 0 ppn

LITI'ER: 47

LITTER SUMMARY


A F 4.0 ABN INr EVC 18/05/93 ABN 18/05/93B M DISCARDED *22/05/93 c M DISCARDED 22/05/93 D M DISCi\RDED 22/05/93E F DISCARDED 22/05/93F F DISCi\RDED 22/05/93G M DISCARDED 22/05/93H F DISCi\RDED 22/05/93I M DISCi\RDED 22/05/93J F DISCARDED 22/05/93K M DISCARDED 22/05/93L F DISCi\RDED 22/05/93M M DISCi\RDED 22/05/93N F DISCi\RDED 22/05/930 M DISCARDED 22/05/93

(") .... r-...... ., ......_,. 0 ...., 1.0

..... 1.0 0:>0

('"")

., ' -I

......

...... ~ 1.0 ......

.... 1.0 o:>....

P.AC905-01/ll


INDIVIDJAL ANIMAL Jlo\TA SllPPLEMENT

APPEmiX 26B

PATHOI..OOY - F2B PUPS GROUP:

PUP ID: 1 IXlSE:

47/A 0 ppn

SEK: F ON STUDY: 1 day (1 >lk) INT EVC

MACRDPATHOI..OOY GENERAL AUTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

·~·

P.AC905-0l/ll

GROUP: LITI'ER:

1 48

IXJSE:

PERCHLOROETHYLENE: MULTIGENERAT.ION INHALATION STUDY IN THE RAT

INDIVIru\1 ANJMI\1 Il!\TA SUPPLEMENT

APPENDIX 26B


n -i r ........., .........,. 0 <0....,

-<0 (X) N

PUP ID

A B c D E F G H I J

SEX

F M M F F F F M M M

BODY wr

CLIN OBS

LITTER SUMMARY

FATE DATE P.M.

LOST 25/04/93DISCARDED 25/04/93DISCARDED 25/04/93DISCARDED 25/04/93DISCARDED 25/04/93 DISCARDED 25/04/93DISCARDED 25/04/93DISCARDED 25Z04/93DISCARDED 25/04/93DISCARDED 25/04/93

DATE IAD

--------- - ---------- ----·-·-~· ----------------

PAC905-0l/ll

PERCHLOROETHYLENE: MllLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVI!JUAL ANIMAL MTA SUPPI..EMENT

APPENDIX 26B

PAT!IOLCGY - F2B PUPS GROUP: 3 OOSE: 300 ppn

LITI'ER: 12l

LITTER SUMMARY

PUP SEX BODY CLlN FATE DATE P.M. DATE IAD ID wr OBS

A F 5.6 ABN INT EVC 21/04/93 ABN 21/04/93 * B M DISCl\RDED 25/04/93c F DISCl\RDED 25/04/93 D F DISCl\RDED 25/04/93 E F DISCl\RDED 25/04/93 F F DISCl\RDED 25/04/93G F DISCl\RDED 25/04/93 H F DISCl\RDED 25/04/93 I M DISCl\RDED 25/04/93 J M DISCl\RDED 25/04/93K M DISCl\RDED 25/04/93L F DISCl\RDED 25/04/93M F DISCl\RDED 25/04/93

...., ..... r-......., .......,. 0 <.0 .....

,_. <.0 co w

''--"' ·-

PAC905-01/ll

PERCHLOBDE'IHYLENE: M.JLTIGENERATION INHALATION STUDY IN THE RAT

INDI.VIOOAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PMHOLCGY - F2B PUPS GROUP: 3 OOSE: 300 ppn

PUP ID: 12J./A SEK: F ON STUDY: 1 day (1 wk) lNl' EVe

MACROPMHOLCGY

THE FOLLCJWIN; MACROSCOPIC OBSERVATIONS WERE MADE STCMAa:l

Contents fluid

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ "0 " ~ " C> UJ

'"

..... UJ CX> ~

-··--· -·--·-------· ----

PAC905-01/ll

PERC![,()ROETifiLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIOOAL 1INlMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOI.J:X;Y - F2B PUPS GROUP: 3 OOSE: 300 ppn

LITI'ER: 124

LITTER SUMMARY

PUP SEX BO!Jl:' CLIN FATE DATE P.M. DATE IAD ID wr OBS

A F LOST 24/04/93B M DISCARDED 24/04/93c M DISCARDED 24/04/93 D F DISCARDED 24/04/93 E M DISCARDED 24/04/93 F F DISCARDED 24/04/93 G M DISCARDED 24/04/93H F DISCARDED 24/04/93 I M DISCARDED 24/04/93J M DISCARDED 24/04/93K M DISCARDED 24/04/93

("")

-1 r-..._ "0 ..._..,. 0 <0 ......

.... <0 ex:> <.TI

~·

PAC905-0l/ll

PERCHLORDETHYLENE: M!JLTIGENERATION INHA!..ATION STUDY IN THE RAT

INDIVIDUAL ANlMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 3 IXJSE: 300 ppnLITTER: 125

LITTER SUMMARY PUP SEX BODY CLIN FATE DATE P.M. DATE lADID wr OBS

A M DISCARDED 25/04/93B F DISCARDED 25/04/93c F DISCARDED 25/04/93 D M DISCARDED 25/04/93E M DISCARDED 25/04/93F M DISCARDED 25/04/93 G F DISCARDED 25)04)93

(") ..... ,......._ ""0 ..._""'01.0.....

1.0000"1

PAC905-0l/ll

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION SWDY IN THE RAT

INDIVIOOAL liNlMAL DATA SUPPLEMENT

APPENDIX 26B

GBDUP: 3 LITTER: 126

roSE: 300 ppnPATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CL1N OBS

FATH fi.\TE P.M. fi.\TE IAD

A B c D E F G H I

M M M M F F M F M

5.5 ABN INT EIJC LOST LOST DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

20/04/93 24/04/9324/04/9324/04/9324/04/9324/04/9324/04/93 24/04/9324/04/93

ABN 20/04/93 *

"-1 ,......., ...... .1:> 0 ....., ""

...... co"" .....,

~-~

'-~ ~

PIIC905-0l/ll

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY lN THE RAT INDIVIlXJAL ANIMAL DATA SUPPLEl1ENT

APPENDIX26B

PATHOLOOY - F2B PUPSGROUP: 3 rosE: 3oo ppnPUP ID: 126/A SEX: M ON STUDY: 1 day (1 ~l lNT EVC

MACROPATHOLOOY

THE FDILCJWIN:; MACROSCOPIC OBSERVATIONS WERE MADE llE'Ml(EV) : Bruising on skull.

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~r

"'0

~"co

'"co

co():>-():>

P.IIC905-0l/ll

PERCHLOJIDETHYLENE: MJLTIGENERATION INHALATION STUDY lll THE RAT

lliDIVIlXIAL l\N1MAL MTA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 3 IXlSE: 300 ppn

LI'ITER: 127

LITTER SUMMARY PUP SEI{ BODY CLlll FATE DATE P.M. DATE IADID wr OBS

A M DISCARDED 26/04/93B F DISCARDED 26/04/93c F DISCARDED 26/04/93 D M DISCARDED 26/04/93 E F DISCARDED 26/04/93F F DISCARDED 26/04/93 G F DISCARDED 26/04/93

(") ...... ,.... "'0 -.;:. -0 u:> ......

..... u:> OJ u:>

~

'-- '--'

r,>.C905-0l/ll

PERCHLORDET!IYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANIMAL IliiTA SUPPLEMENT

APPENDIX 26B

GROUP: 3 LITI'ER: 128

OOSE: 300 Jlllll PATHOLOGY - F2B PUPS

(").... ;-"t:l -.., 0 \D ......

1-' \D \D 0

PUP ID


SEX

F F F M F M M F M M F M F

BODY wr

CLIN OBS

LITTER SUMMARY

FATE DATE P.M.

LOST 26/04/93 DISCARDED 26/04/93DISCARDED 26/04{93DISCARDED 26/04/93DISCARDED 26/04/93 DISCARDED 26/04/93DISCARDED 26/04/93 DISCARDED 26/04/93DISCARDED 26/04/93 DISCARDED 26/04/93 DISCARDED 26/04/93DISCARDED 26{04/93DISCARDED 26/04/93

D.<\TE lAD

····--. -- . --···- ------ -- -----~----

PAC905-0l/ll

PERCHLORDEl'IIYLENE: MULTIGENERATION INHt\LATION STUDY IN THE RAT

INDIVIOOAL .ANM\L DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 3 rosE, 300 ppn

LITTER: 129

LITTER SUMMARY

PUP SEK BODY CLIN FATE DATE P.M. DATE IAD ID wr OBS

A F DISCARDED 26/04/93B M DISCARDED 26/04/93c M DISCARDED 26/04/93D F DISCARDED 26/04/93E F DISCARDED 26/04/93('"')

-I , ....... "0 .........,. 0 ....,""

.... "" ....""

-, -, ,....._/

~· ._..... ..

P.AC905-0l/ll

PERCHLOROETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL AN1MAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLCX;Y - F2B PUPSGROUP: 3 IXJSE: 300 JlllllLITTER: 130

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE lADID wr OBS

A M 4.9 ABN INT EVC 22/04/93 ABN 22/04/93B F *DISCARDED 26/04/93 c M DISCARDED 26/04/93 D M DISCARDED 26/04/93E M DISCARDED 26/04/93F M DISCARDED 26/04/93

(") -i r...._ "0...._""'01.0......

1.01.0N

---

("") -< r...... -c ........,. 0 \0 ......

..... \0

w""

PIIC905-0l/ll

PERC!lLOllDETHYLENE: MULTIGENERATION INHALAl'ION STUDY IN THE RAT

INDIVIOOAL ANlMAL DATA SllPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS PUP

GROUP: ID:

3 130/A

OOSE: 300 SEX:

ppnM ON STUDY: 1 day (l wk) IN!' EVC

MACROPATHOLOGY GENERAL AIJTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

\_../ '~

.t'11C905-0l/11

PERCHLORDEI'HYl..JlNE: MULTIGENERATION 1NHALIITION STUDY IN THE RAT

INDIVIIJUAL AN.Il1AL Jl.\TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 3 !XJSE: 300 ppn

LI'l'l'ER: 132

LITTER SUMMARY


A M DISCARDED 26/04/93B F DISCARDED 26/04/93c M DISCARDED 26/04/93 D M DISCARDED 26/04/93E F DISCARDED 26/04/93F F DISCARDED 26/04/93 G F DISCARDED 26/04/93H M DISCARDED 26/04/93I F DISCARDED 26/04/93J F DISCARDED 26/04/93K F DISCARDED 26/04/93L M DISCARDED 26/04/93

(") -i ,........... "0 ....... 0 ""...., ""

....""""""

PAC905-0l/ll

PERCHLORDETHYLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIIXIAL iiNlMAL M.TA SUPPLEl1ENT

APPENDIX 26B

P.ATIIOLOGY - F2B PUPS GROUP: 3 roSE: 300 ppn

LI'l'I'ER: 133

LITTER SUMMARY

PUP SEX BOD'{ CLIN FATE DATE P.M. DATE IAD ID wr OBS

A F LOST 25/04/93B M DISCARDED 25/04/93c F DISCARDED 25/04/93 D F DISCARDED 25/04/93E M DISCARDED 25/04/93 ("") _,

.._' "'0.._ ""'0 1.0....,

..... 1.0 1.0 c.n

'~ ~~

-PAC905-0l/11

PEE<CHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIMAL DATA SUPPLEMENT

APPENDJX 26B

GROUP: 3 LITIER: 134

IXJSE: 300 P!lllPATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE It\!)

A B c D E F G H

M M M M M M F M

DISCARDED DISCI\RDED DISCI\RDED DISCI\RDED DISCI\RDED DISCI\RDED DISCI\RDED DISCI\RDED

24/04/93 24/04/93 24/04/93 24/04/93 24/04/9324/04/9324/04/9324/04/93

" -l .-... "'C -... 0 .0 """ ...,

.....

.0

.0

"'

PAC905-0l/ll

PERCHWROETHYLENE: M!JLTIGENERAT!ON IN!IALATION STUDY IN THE RAT

INDIVIIXJAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

GBDUP: 3 LITI'ER: 135

D:JSE: 300 ppn PATHOI..CGY - P2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


C"") -1

'-.. -o-....,. 0

"' .....,

..... "' "' .....,

A B c D E F G

M F M F M F F

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

26/04/9326/04/93 26/04/9326/04/9326/04/93 26/04/9326/04/93

-, '-

------·----------~------ --· ------.- ·---

.:AC905-0l/ll

PERCHLORDETHYLENE: MJLTIGENERATION INHI\LATION STUDY lli THE RA:r

INDIVIIXIAL ANn1AL !lATA SUPPLEMENT

APPENDIX 26B


OOSE: 300 ppnPATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLlli OBS

FATH DATE P.M. DATE IAD

A B c D E F

M M M M M M

5.9 ABN INT EVC DISCARDED DISCARDED DISCARDED DISCARDEO DISCARDED

20/04/93 24/0419324/04/9324/04/9324/04/93 24/04/93

ABN 20/04/93 *

n .... r-........ "0 ..........,. 0 ......, ""

..... "" ""co

(") ..... r ....... -o .......... 0 I!>....,

,_. I!> I!> I!>

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHAIIITION STUDY lli THE RAT

INDIVIIX.1l\L ANIMAL DATA stlPPLEMENT

APPENDIX 26B


GROUP: 3 136/A

toSE: SEX: 300 ppn

M ON STUDY: 1 day (1 wk) !NT EVC

MACROPATHOLOGY GENERAL AUTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

-

-t'AC905-0l/ll

PERC!ll..ORDETHYLENE: MULTIGENERA'l'ION INHALATION STUDY IN THE RAT

INDIVIOOt\1 ANll1AL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGRDUP: 3 DJSE: 300 pp:n

LITTER: 137

LITTER SUMMARY

PUP SEX BODY CLIN FATE MTE P.M. MTE IADID wr OBS

A F LOST 22/04/93B F LOST 22)04)93

"-<. ........., ......._,. 0

..... ""

N 0 0 0

PAC905-0l/11

PERCHLORDETHYLENE: MULTIGENERATION INllt\IATION STUDY IN THE RAT

INDIVIWAL AN.IMAL DATA SUPPLEMENT

APPENDIX26B

GROUP: 3 LITTER: 138

OOSE: 300 ppnPATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H

M F F F F F F F

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

18/05/9318/05/93 18/05/93 18/05/9318/05/93 18/05/9318/05/93 18/05/93

(""')_, r ......, ..... .,. 0

...... '""

N 0 0 ....

·-..__/ ·~

l'AC905-0l/ll

PERCIILORDETHYLENE: MULTIGENERATION 1NH/ILATION STUDY IN TilE RAT

INDIVI!XJAL ANM\L DATA SUPPLEMENT

.APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 3 OOSE: 300 P!lilLITTER: 139

LITTER SUMMARY


A F DISCARDED 25/04/93B M DISCARDED 25/04)93c M DISCARDED 25/04/93D F DISCARDED 25/04/93E F DISCARDED 25/04/93F M DISCARDED 25/04/93 G M DISCARDED 25/04/93H F DISCARDED 25/04/93I M DISCARDED 25/04(93

"...... .-...... "'0 ......., 0 \0......

N00N

- --·-- .. - ~---····--·---

PAC905-0l/ll

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXJAL ANlMtiL DATA SUPPLEMENT

APPENDIX 26B

PATHO!..CGY - F2B PUPS GROUP: 3 IXlSE: 300 PJll1LITTER: 140

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IAD ID wr OBS

A F DISCIIRDED 25/04/93B F DISCIIRDED 25/04/93c M DISCIIRDED 25/04/93D M DISCIIRDED 25/04/93E F DISCIIRDED 25/04/93 F M DISCIIRDED 25/04/93G M DISCIIRDED 25/04/93H F DISCIIRDED 25/04/93I F DISCIIRDED 25/04/93J F DISCIIRDED 25/04/93K F DISCIIRDED 25/04/93L M DISCIIRDED 25/04/93M M DISCIIRDED 25/04/93N F DISCIIRDED 25/04/93

("""') -; r-.. -o ...... ... 0

...... ""

N 0 0 w

.~

·~

J?AC905-0l/ll

PERCHLOROEl'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVI!XIAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPS GROUP: 3

LITIER: 142 OOSE: 300 Jlllll

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H

M F F F F F F F

DISCARDED DISCARDED DISCARDED DISCARDED DISC8RDED DISCARDED DISCARDED DISCARDED

26/04/9326/04/9326/04/93 26/04/93 26/04/9326/04/9326/04/9326)04)93

(") -i .-...... -o ...... ..,. 0 ....., ""

N 0 0..,.

P.AC905-01/ll


INDIVDXlAL i\NJMi\L DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 3 roSE: 300 ppn

LITTER: 143

LITTER SUMMARY


A F ABN INT EVC 21/04/93 ABN 21/04/93 * B F DISCARDED 25/04/93c M DISCARDED 25/04/93 D F DISCARDED 25/04/93 E M DISCARDED 25/04/93F F DISCARDED 25/04/93

("") -l

...... ' "0 ......... 0

..... '""

N 0 0 U"1

PAC905-01/ll

PERCHLORDETI!YLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIlXlAL ANJMAL lli\.TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 3 lXlSE: 300 P!lJl

PUP ID: 143/A SEX: F ON STUDY: 1 day (1 M<:) INT EVC

MACRDPAT!!OLOGY

Found dead, cannibalised. Only lower abdaren and hind limbs remaining.

NJ ABNORMALITIES WERE SEEN IN THE ANJMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------('") -! r ...... ...... "" 0 """ 1.0 .......

N 0 0 0'>

PAC905-0l/ll

PERCHI..OROE'I'HYLENE: Ml.lLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL liNJMAL Jl.\TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 3 I:OSE: 300 ppn

LI'ITER: 144

LITTER SUMMARY


A M 6.2 ABN INT EVC 20/04/93 ABN 20/04/93 * B F 3.3 ABN INT EVC 20/04/93 ABN 20/04/93 * c F LOST 24/04/93D M LOST 24/04/93E M LOST 24/04/93F F LOST 24/04/93G F DISCAJIDED 24/04/93H F DISCAJIDED 24/04/93 I M DISCAJIDED 24/04/93J F DISCAJIDED 24/04/93K F DISCAJIDED 24/04/93

_,('")

,... ......., .......,. 0

......"'

' N 0 0 ......

,-,

~ -

PAC905-01/ll

PERCHLOROETIIYLENE: M!JLTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIIXIAL AN"M\1 JliiTA SUPPLEMENT

APPENDIX 26B

PATHOLCX;Y - F2B PUPS GROUP: 3 OOSE: 300 P!Ill

PUP ID: 144/A SEX: M ON STUDY: 1 day (1 wkJ INT EVC

MACROPATHOLCX;Y

TilE FQu.ow:rn:; MACROSCOPIC OBSERVATIONS wERE MADE

S'IU1ACH Contents fluid

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ "0 " ~ " C> ~

'"

N C> C> ():>

PAC905-01/ll

PERCHLORDETIIYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INOIVIlX!AL ANlMAL JliiTA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPS GROUP: 3 OOSE: 300 ppn

PUP ID: 144/B SEX: F ON STUDY: 1 day (1 wk) INT EVC

MACRDPATHOLCGY

THE FOILOWIN:; MACRDSOOPIC OBSERVATIONS WERE MI\DE

STCMACH Gas filled

-------------------------------------------------------END OF PUP------------------------------------------------------------------n -1 r ....._ "'C ....... -!'> 0

"'......

0 0 "' "'

-, ~

.. -·. ·----~·-· ----·- --~- - ~

PAC905-0l/ll


OOSE:

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

lNDlVIIXJt\L ANJMAL JlA.TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS 1000 Jllill

"-i........, ........,. 0 <0....,

N 0 ..... 0

PUP ID


SEX

F F F F F F M F M F F F F

BODY wr

6.2

CLlN OBS

NAD

LITTER SUMMARY

FATE DATE

lNT EVC 26/04/93 LOST 26/04/93 DISCARDED 26/04/93DISCARDED 26/04/93DISCARDED 26/04/93 DISCARDED 26/04/93DISCARDED 26/04/93 DISCARDED 26/04/93 DISCARDED 26/04/93 DISCARDED 26/04/93DISCARDED 26/04/93 DISCARDED 26/04/93 DISCARDED 26/04/93

P.M. DATE IAD

DELETED

("") -l ; ....... "'0 ....... 0""' <a ......

N 0 ...... ......

PAC905-01/ll

PEBCHLORDETHYLENE: MDLTIGENERATION lNHA1..1\1'ION STUDY IN THE RAT

INDI1llLUAL ANlMAL DATA SUPl'LEMENT

APPENDIX 26B

PATHOI.J:)3'{ - F2B PUPS GROUP: 4 IXlSE: 1000 ppn

LITTER: 170

LITTER SUMMARY


A M 7.5 ABN INT EVC 26/04/93 ABN 26/04/93 * B F DISCARDED 26/04/93

,~

~

-··----- -·-. -...........··..._.-·-......-~-

·.. ·· f'AC905-01/ll


INDIVIJXJAL ANIMIIL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4 IXJSE: 1000 ppn

PUP ID: 170/A SEX: M ON STUDY: 5 days (1 wk) INT EVC

MACROPATHOLOGY

THE FDWJWING MACROSCOPIC OBSERVATIONS WERE MADE

URINARY BUDDER Distended

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ -; ~

.__ ~ C> ~ ~

N C> ..... N

----

. ---- ------~---- -------~-------·------

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INIIALATION STUDY IN THE RAT

INDIVIlXIAL M1MAL DATA SUPPLEMENT

APPENDIX 26B

PK!'HOI.CGY - F2B PUPSGROUP: 4 OOSE: 1000 ppn

LITTER: 171


A M 4.8 ABN INT EVC 22/04/93 ABN 22/04/93 B *F LOST 26/04/93c M LOST 26/04/93 D F DISCARDED 26/04/93 E F DISCARDED 26/04/93F M DISCARDED 26/04/93G F DISCARDED 26/04/93H F DISCARDED 26/04/93

("") ..... ...... ' ......""' .., 0

..... ""

N 0 ..... w

/----._ ~

~~

J:'IIC905-01/ll

PERCHLORDETilYLENE: M!JLTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIDUAL ANlMIIL 1:1\TA SUPPLEMENT

APPENDIX 26B

PA:I'llOLOGY - F2B PUPS GROUP: 4 IXJSE: 1000 Jllll1

PUP ID: 171/A SEX: M ON STUDY: 1 day (1 wk) INT EIJC

MACROPA:I'llOLOGY GENERAL iiUI'OLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------(") -;,...._ "'0..._..,. 0 \0....,

N 0 .......,.

--

P.AC905-01/ll

PERCHLOBDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDU/\L .ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GBDUP: 4 IXJSE: 1000 ppn

LITTER: 172

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE lAD ID wr OBS

A M 5.5 ABN INT EVC 17/05/93 ABN 17/05/93 * B F 5.8 ABN INT E'lC 17/05/93 ABN 17/05/93 * c M LOST 21/05/93 D M LOST 21/05/93 E M LOST 21/05/93 F F LOST 21/05/93 G F LOST 21/05/93H F LOST 21/05/93I F LOST 21/05/93 J F LOST 21/05/93K F LOST 21/05/93

('") ..... r -.. "0 -.. ..,. 0 1.0 ......

I

N 0 ..... '-"

-~-~-

-

Pl\C905-01/ll

PERCHLORDETIIYLENE: MDLTIGENERATION INIIAIATION STUDY IN THE RAT

INDIVIDUAL .1\Nlli\L DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4 OOSE: 1000 ppn

PUP ID: 172/A SEX: M ON STUDY: 1 day (1 wk) INT EVC

MACROPATHOLOGY

THE FOu.owm::; MACROSCOPIC OBSERVATIONS WERE MADE

STCMACH Gas filled Distended

-------------------------------------------------------END OF PUP------------------------------------------------------------------

("')

.-! ....... -c ........,. 0 ....,"'

N 0.... en

PAC905-01/ll

PERCHLORDETHYLENE: !1ULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXTAL 1\NlMAL DA.TA SUPPLEMENT

APPENDIX 26B

PATHOLOOY - F2B PUPS PUP ID: GROUP: 4 172/B DJSE: SEX: 1000 F ppn

ON STUDY: 1 day (1 ~) INT E\/C

MACRDPATHOLOOY

THE FOILOWJN:; MACROSCOPIC OBSERVATIONS WERE MADE


-------------------------------------------------------END OF PUP-------------------------------------------------------------------! " ,... .........., .........,. 0 <0 ......

N 0 ..... ......

/~ '~

~

PAC905-0l/ll

PEROiLORDETHYLENE: MDLTIGENERATION lNHAIATION STUDY lN THE RAT

=IVI!XJAL i\NlM8L DATA SUPPLEMENT

APPENDIX 26B

GROUP: 4 LI'ITER: 174

IXJSE: 1000 P!Ill PATHOLOGY - F2.B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLlN OBS


A B c D

u u M M

ABN ABN

INT EVC INT EVC DISCARDED DISCARDED

22/04/9322/04/9326/04/9326/04/93

ABN ABN

22/04/93 22/04/93 *

* (") -l.-..... "'0 ......,. 0 1.0 .....

N 0-0>

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

INDNIIXJM. ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4. IXlSE: 1000 ppn

PUP ID: 174/A SEX: U ON STUDY: 1 day (l wk) INT EVC

MACROPATHOLOGY

fatmd daad, cannibalised. Only head remaining.

NO ABNORMALITIES WERE SEEN lN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------~ ;~ "0 ~ ~ C> UJ

'"

N C> ..... UJ

~.

'-...-"

PAC905-01/11

PERCHLORDETHYLENE: MULTIGENERATION lNHAI..liTION STUDY IN TilE RAT

INDIVIDUAL AN:IWlL DATA StlPPLEl1ENT

APPENDIX26B

PATHOLOGY - F2B PUPS GROUP: 4 OOSE: 1000 Jlllll

PUP ID: 174/B SEX: U ON STUDY: 1 day (1 \k:J INT EVC

MACROPATHOLOGY Found dead, cannibalised. Only head remaining.

NJ ABNJRMALITIES WERE SEEN IN TilE AN:IWlL

-------------------------------------------------------END OF PUP------------------------------------------------------------------'"'"'-i r-"'0 ....... ""' 0 \.0 ......

N 0 N 0

----

PAC905-01/ll

PERCHLOROE'I'HYLENE: MIJLTIGENERATION INl!AIATION STUDY IN THE RAT

INDIVI!X.IAL ANlMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4

LITI'ER: 175 OOSE: 1000 ppn

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS



M M M F F M M F F M F M M

5.2 4.9 6.4 4.7 5.8 5.0 5.7 4.0 4.3

ABN ABN ABN ABN ABN ABN ABN ABN ABN

INT EIIC INT EVC INT EVC INT EIIC INT EIIC INT EIIC INT EIIC INT EVC INT EVC DISCARDED DISCARDED DISCARDED DISCARDED

20/04/93 NAD 20/04/93 NAD 20/04/93 ABN 20/04/93 ABN 20/04/93 NAD 20/04/93 ABN 20/04/93 ABN 21/04/93 ABN 21/04/93 ABN 24/04/9324/04/9324/04/9324/04/93

20/04/9320/04/9320/04/93 20/04/9320/04/93 20/04/93 20/04/93 21/04/93 21/04/93

* * * * * *

-------------------------------------------------------END OF PUP------------------------------------------------------------------

("') -1 r ..._ ..._., ..,. 0 1..0 ......

~ 0 ~ ~

P11C905-01/ll

PERCHLOBDETI:!YLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INOIVIIXJAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PATilOLOGY - F2B PUPSG!«JUP: 4 roSE: 1ooo ppn

PUP ID: 175/C SEX: M ON STUDY: 1 day (1 wkJ INT EVC

MACROPATilOLOGY

Bruising around head and neck.

N::> ABNOFMIILITIES WERE SEEN IN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ ;-

-o " ~ " co co '"

N co N N

PAC905-0l/ll

PERCHLORDE'lliYLENE: MilLITGENERATION INHA!.ATION STUDY lN THE RAT

INDIVI!XJAL ANIMAL DATA SUPPLEMENT

APPENDlX 26B

PATHOLOGY - F2B PUPS GROUP: 4 IXlSE: 1000 Pflll

PUP ID: 175/D SEX: F ON STUDY: l day (l wk) lNT EVC

WICROPATHOLOGY

THE FOlLOWING WICROSCOPIC OBSERVATIONS WERE MADE

KIJ:NEY Pale

STCMACH Gas filled

-------------------------------------------------------END OF PUP------------------------------------------------------------------

('"') -i r ...... "0 ........,. 0 ....., ""

N 0 N w

-·

PAC905-0l/ll

PERCHLORDE'ffiYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDJAL ANlMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS

PUP ID: GROUP: 4 OOSE: 1000 ppn175/F SEX: M ON STUDY: 1 day (1 wk) INT EVC

MACROPATHOLOGY

THE FOlLOWING MACROSCOPIC OBSERVATIONS WERE MADE

STCMIICH Gas filled

-------------------------------------------------------END OF PUP------------------------------------------------------------------~ -; r-"0 -~ -C) ~

'"

N C) N ~

PAC905-0l/ll

PERCHLORDETHYLENE: 11!JLTIGENERATION INHAlATION STUDY lli THE RAT

mDlVIDUAL .IINlMAL DATA SUPPLEMENT

APPENDIX26B


PUP ID: 175/G SEX: M ON STUDY: 1 day (1 'M<:) lNT EVC

MACROPATHOLOGY

THE FOLLOWIN; MACROSCOPIC OBSERVATIONS WERE MADE

STCM<\CH Gas filled

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ -c " ~ " C> 00

'"

C>"' tJ1"'

'...__/ ~

t'AC905-01/ll

PERCHI..OROE'IHYLENE: MULTIGENERATION INEW.IITION STUDY IN THE RAT

INDIVIOOAL 1INlMAL DATA SUPPLEMENT

APPENDIX 26B

P.ATIJoux;y - F2B PUPS GROUP: 4 DOSE: 1000 Pilll

PUP ID: 175/H SEX: F ON STUIJY: 2 days (1 wkl INT EVC

MIICROP.ATHOux;y

THE FOll..OWJN3 MIICROSOOPIC OBSERV.AT.IONS WERE WillE

STCM\CH Gas filled

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ -; r-~ "0 ~ ~ C) ~

'"

N C)

N

"'

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N 0 N....,

PJ\C905-01/ll

PERC!ILDRDETHYLENE: l1DLTIGENERATION INHALATION STUD\.' IN THE RAT

INOlVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX26B PAT!IOLOOY - F2B PUPS

GROUP: 4 IDSE: 1000 ppn PUP ID: 175/I SEX: F ON STUDY: 2 days (1 wk) INT EVC

MI\CROPAT!IOLOOY

GENERAL AllTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

~-

PIIC905-01/ll

PERC!ll..ORDETHYLENE: MULTIGENERATION INHALATION STUDY lN 'lliE RAT

INDIVIIX.!AL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

GROUP: 4 toSE: 1000 LI'l'I'ER: 176

Jlllll PATHOLOGY - F2B PllPS

LITTER SUMMARY

PllP ID

SEX BODY wr

CLlN OBS

FATE DATE P.M. llATE IAil

A B c D E F G H

F F F M F M M M

LOST DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

29/04/93 29/04/93 29/04/93 29/04/93 29/04/93 29/04/9329/04/93 29/04/93

('"")

r -< ...... -o ...... 0"" 0.0....,

N 0 N OJ

-~-~-~--~------ ----·~--·

PAC905-0l/ll


INDIVIIUAL ANJMI\L DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4 IXJSE: 1000 ppn

LITTER: 177

LITTER SUMMARY


A M DISCARDED 24/04/93B M DISCARDED 24/04/93c M DISC!IRDED 24/04/93D F DISC!IRDED 24/04/93E M DISC!IRDED 24/04/93 F F DISCARDED 24/04/93G M DISC!IRDED 24/04/93H F DISCARDED 24/04/93

(""'") -i r -.... '"0 -.... .., 0

...... "'

N 0 N

"'

/

·

-ri\C905-01/ll

PERalLORDETHYLENE: MULTIGENERATION INHAlATION STUDY IN TilE RAT


APPENDIX 26B


LITI'ER: 179

LITTER SUMMARY

PUP SEX EODY CLIN FATE DATE P.M. DATE IADID wr OBS

A F 4.6 ABN INT EVC 22/04/93 ABN 22/04/93 * B F 4.4 ABN INT EVC 22/04/93 ABN 22/04/93 c F * 4.6 ABN INT EVC 22/04/93 ABN 22/04/93 D M * ABN INT EVC 22/04/93 ABN 22/04/93 * E F ABN INT EVC 22/04/93 ABN 22/04/93 * F F LOST 22/04/93G M LOST 22/04/93H M LOST 22/04/93 I M LOST 22/04/93 J F DISCARDED 24/04/93K F DISCARDED 24/04/93

("")

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N 0 w .....

PAC905-0l/ll

PERCHLOBDET!ffi.ENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANJMAL IlA.TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4 lOSE: 1000 ppn

PUP ID: 179/A SEX: F ON STUDY: 3 days (1 wk) 1Nr EVC

MACROPATHOLOGY

GENERAL AUTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

-,~

'"--'

0 ••

§~

CTL/P/4097

-2032

--

PAC905-0l/ll

PERCHLOROETHYLENE: M!JLTIGENERATION INHAlATION STUDY lN THE RAT

INDIVIDUAL ANIMi\1 JltiTA SUPPLEMENT

APPENDIX 26B


PUP ID: 179/C SEX: F ON STUDY: 3 days (1 'Wk) 1NT EVC

MACROPATHOLOGY

THE FOu.awm; MACROSCOPIC OBSERVATIONS WERE MADE

STCM\CH Elnpty

-------------------------------------------------------END OF PUP------------------------------------------------------------------ r) ~

r--o " ~ " C>

'" ~

N C> w w

-~

J?AC905-01/ll

PERCHLOROETilYLENE: MULTIGENERATION lNHliLATION STUDY lN THE RAT

INDIVIIXJAL ANIMAL DATA SUPPLEMENT

.IIPPENDIX26B

PATHOLOGY - F2B PUPS GBDUP: 4 OOSE: 1000 ppn

PUP ID: 179/D SEX: M ON STUDY: 3 days (1 wkJ INT EVC

MI\CROPATHOLOGY

Fotmd daad, cannibalised.

NJ ABNJRMALITIES "ERE SEEN lN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------ r1ri " "0

~ " co uo

'"

N co w ~

PAC905-01/ll

PERCf[J)ROE'l'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVmlAL ANIMAL Th\TA SUPPLEMENT

J\PPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4 D:JSE: 1000 ppn

PUP ID: 179/E SEX: F ON STUDY: 3 days (l t>k) INT EVC

MACROPATHOLOGY

Found dead, cannibalised.

00 ABNOFMALITIES WERE SEEN IN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------~ ;

" "0

~ " co uo '"

N co w t.n

~ ~'

J:'l\C905-0l/ll

PEBCHI..OROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

JNDIVIOOAL ANIMAL ll'ITA SUPPLEMENT

APPENDIX 26B


IXJSE: 1000 ppnPATIJOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLJN OBS

FATE DATE P.M. DATE L\1)

A B c D E F G H

M M M M F F M M

LOST LOST LOST LOST LOST LOST DISCARDED DISCARDED

18/05/9318/05/9318/05/93 18/05/93 18/05/9318/05/9318/05/93 18/05/93

("") .... ...... ' "'0 ........,. 0 <.0 .....

""0 w 0>

-" ~.,. . .. -·---· ···---------·--------·-

PAC905-01/ll

PERCHLORDET!IYLENE: MIJLTIGENERATION INHALATION STUDY lli THE RAT

INDIVIDJAL ANlMiiL DIITA SUPPLEMENT

APPENDIX 26B

PATI!OLCX;Y - F2B PUPS GROUP: 4 OOSE: 1000 PJ:lll

UT'IER: 181

LITTER SUMMARY

PUP SEX BODY CLlli FATE DATE P.M. DATE TAD ID wr OBS

A M DISCARDED 20/05/93B M DISCARDED 20/05/93c M DISCARDED 20/05/93 D M DISCARDED 20/05/93 E F DISCARDED 20/05/93 F F DISCARDED 20/05/93G F DISCARDED 20/05/93 H M DISCARDED 20/05/93 I M DISCARDED 20/05/93 J F DISCARDED 20/05/93K M DISCARDED 20/05/93L F DISCARDED 20/05/93M F DISCARDED 20/05/93 N F DISCARDED 20/05/93

(") -; r ...... -o ........,. 0 lO ......

N 0 w .....

~~

-

----

PAC905-01/ll

PERCHLORDETIIYLENE: MULTIGENERATION INHALATION STUDY IN TilE RAT

OOIVIIJU8L 1\N.!MAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4 !XJSE: 1000 ppn

LITTER: 182

LITTER SUMMARY

PUP SEX BODY CLIN FATE llii.TE P.M. llii.TE IAD ID wr OBS

A M 5.5 ABN INT EVC 22/04/93 ABN 22/04/93B F 6.2 ABN * INT EVC 22/04/93 ABN 22/04/93c M 5.8 ABN INT EVC 22/04/93 * ABN 22/04/93D M 5.5 * ABN INT EVC 22/04/93 ABN 22/04/93E F 4.8 ABN INT EVC 22/04/93 * ABN 22/04/93F M 5.7 * ABN INT EVC 22/04/93 ABN 22/04/93G u * ABN INT EVC 22/04/93 ABN 22/04/93H u * ABN INT EVC 22/04/93 ABN 22/04/93I F 4.4 * ABN INT EVC 23/04/93 ABN 23/04/93 *

("")

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N 0 w 1.0

PAC905-01/ll

PERCHI..ORDE'l'HYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIOOAL ANJM.IIL M.TA SUPPLEMENT

APPENDIX 26B

PATHOI.J:X;Y - F2B PUPS GROUP: 4 OOSE: 1000 ppn

PUP ID: 182/A SEX: M ON STUDY: 1 day (1 wk) INT EVC

MACRDPATHOI.J:X;Y

GENERAL AUroLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

~' ~,

PAC905-01/ll

PERCHLOROE'IHYLENE: MIJLTIGENERATION !NHALATION STUDY IN THE RAT

IND:rv:rooAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B PATHOLCGY - F2B

PUP ID: GROUP: 4

182/B IXJSE:

SEX: 1000

PUPSF

ppnON STUDY: 1 day (1 wk) INT EVC

MACROPATHOLCGY GENERAL AUl'OLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------('"")

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..,.0N

0

-I'"' ....... ' -c ....... 0""' lO ......

0"" .... ""'

P.AC905-01/ll

PERCBLORDE'IHYLENE: MDLTIGENERATION INHAlATION STUDY ill THE RAT

lliOIVIIXIAL ANJM.\L DATA SUPPLEMENT

APPENDlX 26B

PATHOLOGY - F2B PUPS GROUP: 4 IXlSE: 1000 ppn

PUP ID: 182/C SEX: M ON STUDY: 1 day (1 Wk) lliT EVC

MACROPATHOLOGY GENERAL AUI'OLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

'~ ~

PAC905-01/ll

PERCHI.OROETIIYLENE: MULTIGENERATION INHALATION STUDY lll TilE RAT


APPENDIX 26B

PATHO!..CGY - F2B PUPSGROUP: 4 IXJSE: 1000 ppnPUP ID: 182/D SEX: M ON STUDY: 1 day (1 wkl lNT EVC

MACROPATHO!..CGY GENERAL AUI'OLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------(")-f,...........""C........,.0.....,'""

N..,.0

N

--- --------·--~-

PAC905-01/11


INDIVIOOAL ANJMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPS GROUP: 4 I:OSE: 1000 ppn

PUP ID: 182/E SEX: F ON STUDY: 1 day (1 wk) lNT EVC

MACRDPATHOLCGY GENERAL ADTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n -1

....... ' "0 .........,. 0

....."'

N 0..,. w

-~

PAC905-01/ll


INDIVIDllAL AN.lMAL DATA SUPPLEMENT

APPENDIX 268

PATHOLOGY - F2B PUPSGROUP: 4 toSE: 1000 Jlllll

PUP ID: 182/F SEX: M ON STUDY: 1 day (1 wk) INT EVC

MACROPATHOLOGY GENERAL AUTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------ (""') -; r ....... -o .........,. 0 0.0....,

N 0..,...,.

PAC90S-01/11

PERCHLOROETHYLENE: MDLTIGENERA'l'lON INHALATION STUDY IN THE RAT


.APPENDIX 26B

PATHOLCGY - F2B PUPSPUP ID: GROUP: 4 182/G OOSE: SEX: 1000 U Jlll1l

ON STUDY: 1 day (1 wk) INT EVC

WICROPATHOLCGY Fmmd dead, cannibalised. Only head and fore-paws rena:in:ing.

ID .ABN:JBMALITIES WERE SEEN IN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------("")

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N0

c.n""'

..~

~

PAC905-0l/11

PERCHLOROETHYLENE: MJLTIGENERATION lNHAI.ATION STUDY IN THE RAT

INDIVIWAL ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOI1JGY - F2B PUPSGROUP: 4 IXJSE: 1000 ppnPUP ID: 182/H SEX: U ON STUDY: 1 day (1 wk) INT EVC

MACROPATHOI1JGY Fotmd dead, carmibalised. Only head remaining.

NO ABNORMALITIES WERE SEEN IN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~r

"-o ~"C)

'"uo

N0

"'~

PM:905-01/ll

PERCHI..OROETHYLENE: MIJLTIGENERATION INHALATION STUDY ill THE RAT

lliOlVIDUAL 1INIMAL Il.'\TA SUPPLEMENT

APPENDIX 26B


GROUP: 4 182/I IXJSE: SEX: 1000 F ppn

ON STUDY: 2 days (1 'Me) INT EVC

MACROPATHOLOGY

THE FOlLOWING MACROSCOPIC OBSERVATIONS WERE !1WE

INrESTINES(EV) ' Intestines contents clark green/brcmn.S'l'CMACH

Elnpty

-------------------------------------------------------END OF PUP------------------------------------------------------------------

('")

-.., .,. ' -l

-0 \0 .....

N 0.,. ......

PAC905-0l/ll

FERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY lN TilE RAT INDrv:Iru\1 ANJMAL Il!\TA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPSGROUP: 4 OOSE: 1000 ppnLITI'ER: 185

LITTER SUMMARY PUP SEX BODY CLlN FATE 111\TE P.M. 111\TE IADID wr OBS

A F 4.0 ABN INT EVC 23/04/93 ABN 23/04/93B F 4.2 ABN INT EVC 23/04/93 *ABN 23/04/93 c M 3.7 ABN INT EVC 23/04/93 * ABN 23/04/93 D u ABN INT EVC * 23/04/93 ABN 23/04]93 E M 4.3 ABN INT EVC *23/04/93 ABN 23/04/93 F M LOST * 24/04/93

('") -1

....... '"0'.........,.010......

N0..,.co

n -;....... ""0 ...... -1'> 0 \0

"

N 0 -1'> \0

PAC905-01/ll


INDIVIDUAL AN1MAL DATA SUPPLEMENT

APPENDDC 26B

PATHOLOGY - F2B PUPS GROUP: 4 lXlSE: 1000 ppn

PUP ID: 185/A SEX: F ON STUDY: 1 day (1 .,;\c) !NT EVC

MACROPATHOLOGY GENERAL AIITOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

~

PAC905-01/ll

PERCHLOROETI!YLENE: M!JLTIGENEBATION INHt\l..AXION STUDY IN TilE RAT

INDIVIIXJAL AN.IMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPSGROUP: 4 OOSE: 1000 ppnPUP ID: 185/B SEX: F ON STUDY: 1 day (1 wk) INT EVC

MACROPATHOLCGY

TilE rou.owm:; MACROSOOPIC OBSERVATIONS WERE MADE STCMACH

Gas filled

-------------------------------------------------------END OF PUP------------------------------------------------------------------

C)-;r-""0

~"C)

'"U)

NC)c.nC)

PAC905-01/ll

PERCHLOROETIIYLENE: MULTIGENERATION INHALA1'ION STUDY lN THE RAT

INDIVIIXIAL ANIMAL DATA SUPPLEMENT

APPENDIX 2GB

PATHOLOOY - F2B PUPS GROUP: 4. OOSE: 1000 ppn

PUP ID: 185/C SEX: M ON STUDY: 1 clay (1 M<:) lNT EVC

MA.CROPATHOLOOY

THE FQLLOWIN:; MACROSCOPIC OBSERVATIONS WERE MADE

INTESTINES (EV) : Intestmes contents clark brown/green :in colour. S'l'CMACH

Elnpty

-------------------------------------------------------END OF PUP------------------------------------------------------------------

("') --;

-..' -o -..... 0 <D .....

N 0

..... "'

-.

PAC905-0l/ll

PERC!lLORDETHYLENE: MOLTIGENERATION lNHALATION STUDY IN THE RAT

INDIVIDIJAL ANIMAL IlliTA SUPPLEMENT

APPENDIX 26B

PAJ'HOLCGY - F2B PUPSGROUP: 4 OOSE: 1000 pp:nPUP ID: 185/D SEX: U ON STUDY: 1 day (1 wkJ INT EVC

MACRDPATHOLCGY Found dead, cannibalised. Only head mraining.

NO ABNORMALITIES WERE SEEN IN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------ n........ ...._...._""""0

......"'

N0<.11N

----··· ---·~-----

PAC905-0l/ll


INDIVIOOAL ANlMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLCGY - F2B PUPSGliDUP: 4 OOSE: 1000 ppn

PUP ID: 185/E SEX: M ON STUDY: 1 day (1 wk) INT E.VC

MACROPATHOLCGY GENERAL illlTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

("") -i, ....... -o ....... <3 ....,""

N 0 U1 w

.----..

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION IN!Il\UTION STUDY JN THE RAT

INDIVJIXJAL ANIMAL IWl'A SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 4 IXJSE: 1000 ppnLITTER: 186

LITTER SUMMARY PUP SEX BODY CLJN FATE DATE P.M. DATE IADID wr OBS

A F LOST 25/04/93B F DISCARDED 25/04/93c M DISCARDED 25/04/93D F DISCARDED 25/04/93E F DISCARDED 25/04/93F F DISCARDED 25/04/93G M DISCARDED 25/04/93H F DISCARDED 25/04/93I M DISCARDED 25/04/93J F DISCARDED 25/04/93

....." ......r ., ........,. 0 ...., 1.0

N0U1..,.

PIIC905-0l/ll

PERC!ILORDETIIYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIJUAL ANM\.L DATA SUPPLEMENT

.APPENDIX 2.6B

PATHOLCGY - F2B PUPS GROUP: 4 OOSE: 1000 JlllllLITl'ER: 187

LITTER SUMMARY


A F 4.6 ABN INT E\TC 2.1/04/93 ABN 2.1/04/93 *B F DISCARDED 2.5/04/93c M DISCARDED 2.5/04/93D M DISCARDED 2.5/04/93 E M DISCARDED 2.5/04/93F M DISCARDED 2.5/04/93G M DISCARDEO 2.5/04/93H F DISCARDED 2.5/04/93I F DISCARDED 2.5/04/93

-1 '"' ........., ...... ... 0 \0....,

N 0 (Jl (Jl

-·~,'~ ~

PAC905-0l/11



APPENDIX 26B

PAT!!Ou:x;y - F2B PUPSGROUP: 4 roSE: 1000 P!lllPUP ID: 187/A SEX: F ON STUDY: 1 day (l wkl INT EVC

MACROPAT!!Ou:x;y

THE FOLLOWING MACROSCOPIC OBSERVATIONS 'WERE MADE

S'l'CMACHElrqlty

-------------------------------------------------------END OF PUP------------------------------------------------------------------

r1-ir "-c ~"C)UJ

'"

NC) U1C"1

("") ....;

-....' "'0-....... 0 ....., "'

0"' <.TI.....,

PAC905-0l/ll

PERCHLOROETHYLENE: MllLTIGENERATION INHAlATION STUDY JN THE RAT

INDIVIIXJ&. ANIMAL DATA SUPPLEMENT

APPENDIX 26B

PATilOLOGY - F2B PUPS GROUP: 4 OOSE: 1000 Jlllll LITTER: 188

LITTER SUMMARY

PUP SEX BODY CLJN FATE DATE P.M. DATE IAD ID wr OBS

A M 5.8 ABN INT EVC 21/05/93 ABN 21/05/93 B F * LOST 25/05/93C M LOST 25/05/93

~ .~.

~

PIIC905-01/ll

PERCHLOROET!M.ENE: MULTIGENERATION INHALATION STUDY lli THE RAT

lliDIVIIXIi\L iiN1MAL l:l!\XA SUPPLEMENT

APPENDIX 268

PATHOLOGY - F2B PUPSGROUP: 4 !XlSE: 1000 PfDlPUP ID: 188/A SEX: M ON STUDY: 1 day (1 wk) INT EVC

MACROPATHOLOGY GENERAL AU!'OLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------ n-i

'.......-o.........,. co0

.......

N0U1OJ

PAC905-01/ll

PERCHLOROETilYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL .1\NJMAL DATA SUPPLEMENT

APPENDIX 26B


IXJSE: 1000 P1lll PATHOLOGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


r. -1 r ....... -o .......... 0 lO....,

N 0 01 lO

A B c D E F G H I

M M F F M F F F M

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

26/04/9326/04/9326/04/9326/04/9326/04/9326/04/9326/04/9326/04/9326/04/93

~, ~

PAC905-01/ll

l'ERCHLOROE'!'HYLENE: MULTIGENERATION IN!!l\LATION STUDY IN THE RAT

INDIVIIX!AL ANlMAL Il!\TA SUPPLlliENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 4 OOSE: 1000 ppnLITI'ER: 190


A M 4.5 ABN INT EVC 20/04/93 ABN 20/04/93B F 4.5 ABN *INT EVC 20/04/93 ABN 20/04/93 c M DISCARDED 24/04)93 * D F DISCARDED 24/04/93E M DISCARDED 24/04)93F F DISCARDED 24/04/93

n --; r.._ '"0.._""'01.0.._,

N0O'l0

PAC905-01/ll

PERCHLOROETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RA:l'

INDlVIOOAL ANlMAL DATA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPS GROUP: 4 !XlSE: 1000 P!lil

PUP ID: 190/A SEX: M ON STUDY: 1 day {1 wk) INT EVC

MACROPATHOLOGY

THE FOlLOWING MACROSOOPIC OBSERVATIONS WERE MADE

STCMACII Elnpty

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ "0 " ~ " C> UJ

'"

N C> ,_. ""

~ .~

~

P.AC905-01/ll

PERCHLOROETHYLENE: MIJLTIGENERATION IN!!ALATION STUDY IN THE RAT

INDIVIIXIAL ANlMAL J:liiTA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 4 OOSE: 1000 P!Jll

PUP ID: 190/B SEX: F ON STUDY: 1 day (1 >k:J INT EVC

MACROPATHOLOGY

THE FOI..l..OWIID MACROSCOPIC OBSERVATIONS WERE MADE

STCMIICHElrqlty

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n-ir-.... -o........,.0<.0......

"'00'1

"'

P.AC905-01/ll

PERCHLORDETHYLENE: Ml.JLTIGENERATION JNHAI.ATION STUDY IN THE RAT

INDIVIJXfAL .ANlMAL DATA SUPPLEMENT

APPENDIX 26B

GROUP: 4 LITJ'ER: 191

DOSE: 1000 ppn PATHOLCGY - F2B PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr CLIN OBS


A F LOST 18/05/93

("') --i

....... ' -c ....... ~ 1.0 ......

N 0 01 w

-

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION INHA!.ATION STUDY IN THE RAT

INDIVIIJUAL ANIMAL Jl.\TA SUPPLEMENT

APPENDIX 26B

PATHOLOGY - F2B PUPSGROUP: 4 OOSE: 1000 ppnLITTER: 192

LITTER SUMMARY PUP SEX BODY CLIN FATE !1<\TE P.M. !1<\TE IADID wr OBS

A M ABN INT EVC 18/05/93 ABN 18/05/93B M 5.5 ABN INT EVC 18/05/93 ABN 18/05/93c u ABN INT EVC 18/05/93 * *ABN 18/05/93 D M DISCARDED 22/05/93 *E M DISCARDED 22/05/93F F LOST 22/05/93

n --! r--o----..,.0

"''-J

N0

""..,.

---

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT

INDIVIOOE\L ANlMAL DATA SUPPLEMENT

APPENDIX 26B


PUP ID: 192/A SEK: M ON STUDY: 1 day (1 wk) INT EIJC

MACROPATHOLOGY

Fotmd daad, canni.balised.

NO ABNORMALITIES WERE SEEN IN THE ANlMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ ;

"0 " ~ " C)

'" ~

N C)

(,J1 "'

PAC905-0l/ll

PERCHLOROETHYLENE: MDLTIGENERATION INHALATION SWDY lli THE: RAT

lNDl.VIOOAL AN1MAL DATA SUPPLl!l1ENT

APPENDIX 26B PAT!!Ol..OOY - F2B

PUP ID: GROUP: 4 192/B rosE:

SEX: 1000

PUPSM Jlllll

ON SWDY: 1 day (1 wkJ INT EVC

MACROPAT!!Ol..OOY GENERAL AlJI'OLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------n

......r-i

.,......""'01.0....,

N0

"'"'

PAC905-01/ll

PERCHLORDETHYLENE: MJLTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIDUAL ANIMAL Il!\TA SUPPLEMENT

APPENDIX 26B

PATHOI.OOY - F2B PUPSGROUP: 4 IXlSE: 1000 ppn

PUP ID: 192/C SEX: U ON STUDY: 1 day (1 M<:) INT EI/C

MIICRDPATHOI.OOY Found dead, cannibalised.

NO ABN:JRMALITIES WERE SEEN IN TilE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ~ r

"-o " ~ ~

'"

N 0

..... "'

~-



APPENDIX 26C

PATHOLOGY - F2C PUPS

Key:

M = male F = female PM = post mortem ABN = abnormal lAD = individual animal data sheetINT = intercurrent EVC = evisceration WT = weight CLIN OBS = clinical observationsID = identification* = lAD present

CTL/ PI4097 - 2068

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION JNHAI..\TION STUDY IN THE RAT

INDIVIDUI\L liN.Il1IIL Il'ITA SUPPLEMENT

APPENDIX 26C


DJSE: 0 pj:Ill PATHOLOGY - F2C PUPS

PUP ID

SEX BODY wr

CLIN OBS

LITTER

FATE

SUMMARY

DATE P.M. DATE lAD

C") -i r ...... "'0 ........,. 0 1.0.._,

N 0

"'1.0


M M M F F M M M F F M M F

LOST DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

10/05/9310/05/9310/05/9310/05/9310/05/9310/05/9310/05/9310/05/9310/05/9310/05/9310/05/9310/05/9310/05/93

PAC905-01/ll

PERCHI..ORDETHYLENE: MULTIGENERATION INHAI..A1'ION ST!IDY IN THE RAT

INDI\TilXJAL ANJMi\L DATA stJllPUMENT

APPENDIX 26C

PATHOLOGY - F2C PUPS GROUP, 1 roSE, 0 pjlll

LITTEll> 202

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IllD ID wr OBS

A M DISCARDED 10/05/93B M DISCARDED 10/05/93C M LOST 10/05/93

...., -1

....... ' -c ....... ~ 0.0 .....

N 0 ..... 0

"- -~"

PAC905-0l/ll

PERCHLORDSI'HYLENE: MULTIGENERATION INHAI..ATION STUDY IN THE RAT

INDIVIOOAL ANIMAL DATA SUPPLEMENT

APPENDIX 26C

PATilOLOGY - FZC PUPS GROUP: 1

LI'ITER: 203 roSE: 0 ppn

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H I J K L

M M F M F M F F M F F F

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

28/05/9328/05/9328/05/9328/05/9328/05/93 28/05/9328/05/93 28/05/93 28/05/93 28/05/9328/05/9328/05/93

"--l r-....... "'0 ........,. 0 ...., "" I

N 0....,-

PAC905-0l/ll

PERCHLOROETHYLENE: Ml.!LTIGENERAT!ON INHALATION STUDY IN THE RAT

INDIVmli\L ANlMi\L lliiTA SUPPLEMENT

APPENDIX 26C

PATHOI.mY - FZC PUPSGROUP: l OOSE: 0 ppn

LI'ITER: 204

LITTER SUMMARY


A M LOST 08/05/93B F DISCARDED 08/05/93c F DISCARDED 08/05/93 D F DISCARDED 08/05/93E F DISCARDED 08/05/93F M DISCARDED 08/05/93G F DISCARDED 08/05/93H F DISCARDED 08/05/93I F DISCARDED 08/05/93J F DISCARDED 08/05/93

('"') -l r ....... -c ........., 0 lO ....,

"'......0

"'

~-

--

P.AC905-01/ll

PEBl:HLOROE'!'HYLENE: MULTIGENERATION INHMATION STUDY IN THE RAT

INDIVIDUAL ANJJ:1AL DATA SUPPLEMENT

APPENDIX 26C

PATHOI..CGY - F2C PUPSGROUP: 1 DJSE: 0 PJlllLITTER: 205

LITTER SUMMARY


A M DISCARDED 10/05/93B F DISCARDED 10/05/93C F DISCARDED 10/05/93n

......r-1

......""'0

""' 'D....,

N0....,w

PAC905-0l/11


INDIVIDJi\L ANJMAL Il!\.TA SUPPLEMENT

APPENDIX 26C


!XlSE: 0 ppnPATHOLOGY - F2C PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS



F F M M F M M M F F M M F

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

09/05/9309/05/9309/05/93 09/05/93 09/05/93 09/05/9309/05/9309/05/9309/05/9309/05/9309/05/9309/05/9309/05/93

C"") -; r-...... ...... " -"" 0

..... '""

N 0....., -""

~

PAC905-01/ll

PERCHLORDEI'HYLENE: MULTIGENERATION INfli\LATION STUDY IN THE RAT

INOIVI!XL\L ANIMAL DATA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPSGROUP: 1 IDSE: 0 ppnLITI'ER: 207


A F LOST 10/05/93B M DISCARDED 10/05/93c M DISCARDED 10/05/93 D M DISC'JIRDED 10/05/93E M DISCARDED 10/05/93F M DISC'JIRDED 10/05/93G M DISC'JIRDED 10/05/93H M DISC'JIRDED 10/05/93I M DISCARDED 10/05/93J M DISCARDED 10/05/93K F DISCARDED 10/05/93L F DISCARDED 10/05/93

('"") -l r...... ......"..,. 0 <.0 ....,

'

....,0N

U1

PAC905-0l/ll


DJSE:

PERCHLOROE'l'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMAL Ilii.TA SllPPLEMENT

.APPENDIX 26C

PA'l'l!OLOGY - F2C PUPS0 ppn

<"">....;

'-... -o-... -1'> 0 \0.....,

N 0 ...... "'

PUP ID

A B c D E F G H I J K L M N 0

SEX

M M F M F F F F F F F F M F F

BODY wr

CLIN OBS

LITTER SUMMARY

FATE DATE P.M.

DISCABDED 09/05/93DISCARDED 09/05/93DISCABDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCABDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCARDED 09/05/93DISCABDED 09/05/93

DATE IAD

PAC905-01/ll


INDIVIDUAL ANJMAL DATA SUPPLEMENT

APPENDIX 26C


OOSE: 0 Pfll1PATHOLOGY - FZC PUPS

LITTER SUMMARY

PUP m

SEX BODY wr

CLIN OBS


A F LOST 08/05/93

"-i -., r

-0""' ....., '"'

N 0 ....., .....,

PAC905-0l/ll

PERCHLOROEI'HYLENE: MULTIGENERATION INHAlATION STUDY lli THE RAT

INOIVIIJUAL ANlMAL DATA SUPPLEMENT

APPENOIX26C

PATHOLOOY - FZC PUPS GROUP: 1 IXJSE: 0 ppn

LI'l'l'ER: 210

LITTER SUMMARY

PUP SEX BODY CLlli FATE DATE P.M. DATE IADID wr OBS

A M 6.6 ABN INT EVC 04/05/93 ABN 04/05/93 * B F DISCARDED 08/05/93c M DISCARDED 08/05/93D M DISCARDED 08/05/93E M DISCARDED 08/05/93F M DISCARDED 08/05/93G F DISCARDED 08/05/93H F DISCARDED 08/05/93

n -l,... ....... "0 ........,. 0.., .....

N 0 ..... ():)

- --~,

P.IIC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN TilE RAT

INDIVIlXJAL ANIMAL DATA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPSGROUP: 1 IXJSE: 0 ppn

PUP ID: 210/A SEX: M ON STUDY: 1 day (1 wkJ INT EVl::

MACROPATHOLOGY

GENERAL AIITOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------ ("') -1

........, r

........., 0 ....,""

0"' ...., ""

P;\C905-0l/ll

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 26C

GROUP: 1LIITER: 211

IXlSE: 0 P!Jil PATHOLCGY - F2C PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr CLIN OBS


A F LOST 08/05/93

("") -; r ....... "0 ....... ""'0 <D ......

N 0 co 0

/""' ~,

PAC905-01/ll

PERCHLORDETHYLENE: !11LTIGENERATION INHALIITION STUDY IN THE RAT

INDIVIIX!AL ANlli\L DATA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - FZC PUPS GROUP: 1

LITI'ER: 212 DJSE: 0 ppn

LITTER SUMMARY

PUP ID

SEX EODY wr

CLIN OBS

FATE ll'ITE P.M. ll'ITE IAD

A B c D E F G H I J K L M N 0

F F F F F M M FM F M M M F M

5.1 ABN INT EVC DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED LOST

04/05/93 08/05/93 08/05/93 08/05/93 08/05/9308/05/9308/05/93 08/0S/93 08/05/93 08/05/9308/05/9308/05/9308/05/93 08/05/93 08)05)93

ABN 04/05/93 *

(") --; , ....... -c ....... ..,. 0 ...., ""

N 0 OJ ......

---

PAC905-0l/ll


INDIVIru\L ANlMAL JlA.TA SUPPLEMENT

APPENDIX26C

PA'I'l!OLOGY - F2C PUPS GROUP: l OOSE: 0 PJll1

PUP ID: 2:J.2/A SEX: F ON STUDY: 1 day (1 M<) INT EVC

MACROPA'I'l!OLOGY

THE FOLL.OWTIK; MACROSCOPIC OBSERVATIONS WERE MADE

STCMACH E:npty

-------------------------------------------------------END OF PUP------------------------------------------------------------------

C)-; r-"0 " ~ " C) uo ~

N C) ():) N

PIIC905-0l/ll

PERCHLORDETHYLENE: MULTIGENERA!ION INHALATION STUDY IN THE RAT

INDIVIDJAL ANlMAL DATA SUPPUMENT

APPENDIX 26C

PATHOLOGY - F2C PUPSGROUP' 1 IXJSE' 0 PJ:IllLI'ITER: 213

LITTER SUMMARY

PUP SEX BODY CLIN FATE MTE P.M. DATE IADID wr OBS

A M LOST 09/05/93B F LOST 09/05/93

"-..r-<

"'0-.."""0

""......

N

co0

w

. -- . ·- ----- --·-----····

PAC905-01/11


INDIVIlXIAL ANJMAL Jl.\TA SUPPLEMENT

APPENDIX 26C

PATHOI..OOY - F2C PUPSGllDUP: 1 OOSE: 0 ppn

LITI'ER: 214

LITTER SUMMARY


A M DISCARDED 10/05/93B F DISCARDED 10/05/93c M DISCARDED 10/05/93D F DISCARDED 10/05/93E F DISCARDED 10/05/93F M DISCARDED 10/05/93G M DISCARDED 10/05/93H M DISCARDED 10/05/93I M DISCARDED 10/05/93J M DISCARDED 10/05/93K M DISCARDED 10/05/93L F DISCARDED 10/05/93M M DISCARDED 10/05/93N M DISCARDED 10/05/93

.-("")-i

........,

.........,.01.0......

0co N

..,.

~-

'-/

PAC905-0l/ll

PEBCHI..ORDETilYLENE: MDLTIGENERATION JNHA!ATION STUDY IN THE RAT

INDIVI!XJAL ANIMAL JliiTA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPS GROUP: 1 rosE: 0 ppn

LITTER: 215

LITTER SUMMARY


A M DISCARDED 08/05/93B F DISCARDED 08/05/93c F DISCARDED 08/05/93D F DISCARDED 08/05/93 E F DISCARDED 08/05/93F F DISCARDED 08/05/93G M DISCARDED 08/05/93 H F DISCARDED 08/05/93 I F DISCARDED 08/05/93J M DISCARDED 08/05/93K F DISCARDED 08/05/93L F DISCARDED 08/05/93M M DISCARDED 08/05/93

-< " .-.........., ........ 0 ""' ...., ""

N 0 OJ U1

--

P.AC905-0l/11

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDJ:VIOOAL ANlMAL IliiTA SUPPLEMENT

APPENDIX 26C

PATHOLCGY - F2C PUPSGROUP: 1 DJSE: 0 ppn

LITTER: 216

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IADID wr CBS

A F DISCARDED 11/05/93B F DISCARDED 11/05/93c F DISCARDED 11/05/93 D F DISCARDED 11/05/93 E F DISCARDED 11/05/93 F M DISCARDED 11/05/93 G M DISCARDED 11/05/93 H M DISCARDED 11/05/93I M DISCARDED 11/05/93J M DISCARDED 11/05/93

(') -! r-"'0 .,. --0 I.D .....

N 0 CD en

PAC905-0l/ll

PERCHLOROE'IHYLENE: MIJLTIGENERATION INHliiATION STUDY IN THE RAT

INDIVIOOEIL ANJMAL lWI'A SUPPLEMENT

APPENDIX 26C

PATHOLOGY - FZC PUPSGBDUP: 1 OOSE: 0 ppn

LITI'ER: 217

LITTER SUMMARY PUP SEX EODY CLIN FATE DATE P.M. DATE IADID wr OBS

A F LOST 27/05/93B F DISCARDED 27/05/93c M DISCARDED 27/05/93D M DISCARDED 27/05/93E M DISCARDED 27/05/93F F DISCARDED 27/05/93G M DISCARDED 27/05/93H F DISCARDED 27/05/93I M DISCARDED 27/05/93J M DISCARDED 27/05/93K F DISCARDED 27/05/93L F DISCARDED 27/05/93M F DISCARDED 27/05/93 N F DISCARDED 27/05/93

"-1 .-"'C --"""0 ~ ....,

N

OJ0....,

PAC905-0l/11

PERCHI.ORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDJAL ANIMAL DATA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPSGllDUP: 1 OOSE: 0 Jl!l1lLI'ITER: 218

LITTER SUMMARY


A F DISCARDED 11/05/93B F DISCARDED 11/05/93c M DISCARDED 11/05/93D F DISCARDED 11/05/93E F DISCARDED 11/05/93 F M DISCARDED 11/05/93G M DISCARDED 11/05/93H F DISCARDED 11/05/93 I M DISCARDED 11/05/93 J M DISCARDED 11/05/93 K F DISCARDED 11/05/93L M LOST 11/05/93M F LOST 11/05/93

(""') ..... r-...... '"tl ...... 0 \0 ""' ....,

0"' ():> ():>

'----'

(")

.....

......,r-<

0-"' \0......

N0OJ\0

PAC905-0l/ll

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT INDIVJIX.ll\L ANlM/\L llii.TA SUPPL"EMNT

APPENDIX 26C

PATHOLOGY - F2C PUPSGROUP: 1 IXJSE: 0 JlllllLITI'ER: 219


A M DISCARDED 09/05/93B M DISCARDED 09/05/93c M DISCARDED 09/05/93D M DISCARDED 09/05/93 E F DISCARDED 09/05/93F M DISCARDED 09/05/93G F DISCARDED 09/05/93H F DISCARDED 09/05/93I F DISCARDED 09/05/93J F DISCARDED 09/05/93K M DISCARDED 09/05/93L F DISCARDED 09/05/93M F DISCARDED 09/05/93N F DISCARDED 09/05/930 F DISCARDED 09/05/93p F LOST 09/05/93

P1\C905-0l/ll


INDIVIOOAL AN1MAL DATA SUPPLEMENT

.1\PPENDIX 26C

PA'l'HOLCGY - F2C PUPS GROUP: 1 OOSE: 0 ppn

LI'l'l'ER: 220

LITTER SUMMARY


A M DISCARDED 09/05/93B F DISCARDED 09/05/93c M DISCARDED 09/05/93 D M DISCARDED 09/05/93 E F DISCARDED 09/05/93F F DISCARDED 09/05/93G M DISCARDED 09/05/93 H F DISCARDED 09/05/93 I F DISCARDED 09/05/93 J M DISCARDED 09/05/93K F DISCARDED 09/05/93L M DISCARDED 09/05/93M F DISCARDED 09/05/93N F LOST 09/05/93

("') -1 ; ....... -o ........,. 0 0.0 ......

0"' 0.0 0

PAC905-01/ll

PERCHLOROETHYLENE: MOLTIGENERATION INHAlATION STUDY IN THE RAT

INDlVIlXIIIL ANIMIIL 11>\TA SUPPLEMENT

APPENDIX 26C

GRDUP: 1 LITTER: 221

!XlSE: 0 Pf1ll PATHOLOGY - F2C PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


n -i r-.. "'C-.. ""'0

"' "

N 0

"'......

A B c D

M F F M

DISCARDED DISCARDED DISCARDED DISCARDED

10/05/9310/05)9310/05/9310/05/93

---

PAC905-0l/ll

PERCHLOROE'ffiYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIIXJAL ANIM!1L DATA SUPPLEMENT

APPENDJX 26C

PATHOLOGY - FZC PUPS GROUP: 1 roSE: 0 ppn

LITI'ER: 223

LITTER SUMMARY


A M DISCAR!lEil 08/05/93B F DISCARDED 08/05/93C F DISCARDED 08/05/93

('"') -i ; ........., ........,. 0 1.0....,

0"" 1.0

""

'---'

PAC905-0l/ll

PERO!LOROETHYLENE: MULTIGENERATION INHAlATION SWDY IN THE RAT

INDIVIIXlAL ANIMAL Jl.\TA SUPPIDlENT

APPENDIX 26C

PATHOLCGY - F2C PUPS GROUP: l OOSE: 0 ppn

LITI'ER: 224

LITTER SUMMARY

PUP SEX BODY CLIN FATE MTE P.M. MTE lADID wr OBS

A M DISCARDED 08/05/93B M DISCARDED 08/05/93c F DISCARDED 08/05/93D M LOST 08/05/93E M LOST 08)05/93F M LOST 08/05/93G M LOST 08/05/93 H F LOST 08/05/93 I F LOST 08/05/93J F LOST 08/05/93K F LOST 08/05/93

n -i

........, '

...... 0""' \0 ....,

I

N 0 \0 w

--

PAC905-0l/ll

PERCHLOROETHYLENE: MIJLTIGENEBATION INHALATION STUDY Til THE RAT

INDIVIOOAL ANlMAL DATA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPS GROUP: 4 lXlSE: 1000 ppn

LITI'ER: 225

LITTER SUMMARY

PUP SEX BODY CLlll FATE DATE P.M. DATE IAlJ ID wr OBS

A M s.s ABN INT EVC 05/05/93 ABN 05/05/93 * B M DISCARDED 09/05/93c M DISCARDED 09/05/93 D M DISCARDED 09/05/93 E F DISCARDED 09/05/93 F M DISC&IDED 09/05/93 G M DISC&IDED 09/05/93H M DISCARDED 09/05/93I M DISC&IDED 09/05/93J M DISCARDED 09/05/93K M DISC&IDED 09/05/93L M DISC&IDED 09/05/93M M DISC&IDED 09/05/93N M DISC&IDED 09/05/930 F DISC&IDED 09/05/93p F LOST 09/05/93

r; -1 r--o --0 ""' ...., '""

N 0

'"" ""'

~-~

PAC905-0l/ll

PERCHLORDEI'HYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT INDIVIDUAL ANn1AL DIITA SUPPLEMENT

APPENDIX 26C

Pli1'HOLCGY - F2C PUPSGROUP: 4 DJSE: 1000 ppn

PUP ID: 225/A SEX: M ON STUDY: 1 day (1 M<) TNT EVC

MACROPA1'1lOLCGY

THE FOI..LOWIN:: MACROSCOPIC OBSERVATIONS WERE MADE STCMI\CH

DistendedURINARY BLIIDDER

Distended

-------------------------------------------------------END OF PUP------------------------------------------------------------------

(")

.-I ........""0.........,.0

"<0

N0<0c.n

PAC905-01/11

PERCBLOROETHYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIOOAL ANIMAL M.TA SUPPLEl1ENT

APPENDIX26C

PATI!OLOGY - F2C PUPS GROUP: 4 OOSE: 1000 ppn

LITTER: 226

LITTER SUMMARY


A M DISCARDED 10/05/93B M DISCARDED 10/05/93c M DISCARDED 10/05/93D F DISCARDED 10/05/93E M DISCARDED 10/05/93F M DISCARDED 10/05/93G M DISCARDED 10/05/93H F DISCARDED 10/05/93I F DISCARDED 10/05/93J F DISCARDED 10/05/93K F DISCARDED 10/05/93L F LOST 10/05/93

('"')

........., ' -I

....... ""'0 .., ......

N 0.., "'

··-·

PiiC905-0l/11

PERCHLORDETHYLENE: MIJLTIGENERATION INlll\LATION STUDY Til THE RAT

OOIVIIJUliL i\NJMIIL DATA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPSGROUP: 4 lXJSE: 1000 ppn

LI'ITER: 227

LITTER SUMMARY

PUP SEX BODY CLTII FATE DATE P.M. DATE IADID wr OBS

A F 5.8 ABN INT EVC 05/05/93 ABN 05/05/93B F *DISCARDED 09/05/93 c M DISCARDED 09/05/93 D F DISCARDED 09/05/93E F DISCARDED 09/05/93F M DISCARDED 09/05/93 G F DISCARDED 09/05/93H M DISCARDED 09/05/93I M DISCARDED 09/05/93J M DISCARDED 09/05/93K F DISCARDED 09/05/93L F DISCARDED 09/05/93M M LOST 09/05/93

("")

,...-i

...... "'0 ...... ""'"0 ..,......

N0..,.....

PllC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHIILATION STUDY IN THE RAT

INDI.VIJXJAL ANJMAL DATA SUPPLEMENT

liPPENDIX 26C

PAl'HOI..OOY - F2C PUPS PUP ID:

GROUP: 4 227/A I:OSE:

SEX: 1000

F ppnON STUDY: 1 day (1 >k) INT EVC

MI\CROPAl'HOI..OOY GENERAL AIJTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

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1'0 0

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PAC905-0l/ll

PERCHLOROE'I1lYI.I!M: M!JLTIGENERATION INHAUTION STUDY IN THE RAT

INDIVIDUAL AN1MIIL DATA SUPPLEMENT

APPENDIX 26C

PAlliOLOGY - FZC PUPS GROUP: 4

LI'ITER: 228 OOSE: 1000 ppn

LITTER SUMMARY

PUP ID

SEK BODY wr

CLIN OBS


A B c D E F G H I J K ' '"'

M M M F M M M M F M M F

DISCI\RDED DISCARDED DISCARDED DIS"...AIIDED DISCARDED DISCJ\RDED DISCJ\RDED DISCARDED DISCARDED DISCJ\RDED DISCARDED LOST

09/05/9309/05/9309/05/9309/05/93 09/05/93 09/05/9309/05/9309/05/93 09/05/9309/05/9309/05/9309/05/93

-i" r--... "tl -... 0""' ...... "'

N 0

"' "'

PIIC905-0l/ll

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY Til THE RAT

INDIVIOOAL ANJMAL DATA SUPPLEMENT

APPENDIX 26C


OOSE: 1000 ppn PATHOI..(X;Y - F2C PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLTII OBS


"-i r..._ "0..._.., 0 1.0....,

N.... 0 0


M M M M F M F F F M F F M

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

27/05/9327/05/9327/05/9327/05/9327/05/9327/05/9327/05/9327/05/9327/05/9327/05/9327/05/9327/05/9327/05/93

~.

'-'

-P.I\C905-0l/11

PERCHLOROETHYLENE: MJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVI!XJAL ANlMliL DATA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPS GROUP: 4 !XJSE: 1000 ppn

LITI'ER: 247

LITTER SUMMARY


A M 4.7 ABN INT EVC 07/05/93 ABN 07/05/93 * B M 4.6 ABN INT EVC 07/05/93 NAD 07/05/93c F DISCIIRDED 11/05/93 D F DISCilRDED 11/05/93 E F DISCilRDED 11/05/93F M DISCilRDED 11/05/93G M DISCilRDED 11/05/93 H F DISCIIRDED 11/05)93 I M DISCIIRDED 11/05/93 J F DISCIIRDED 11/05/93K M DISCIIRDED 11/05/93L F DISCilRDED 11/05/93M M DISCilRDED 11/05/93

(") -! ,.... ......., ........,. 0 ...., "'

N--..,.

,_

PAC905-01/ll


INDIVIIJUAL ANIJ.!AL DATA SUPPLEMENT

APPENDIX 26C

PATIIOLCGY - F2C PUPSGROUP: 4 OOSE: 1000 Jlllll

PUP ID: 246/A SEK: F ON STUDY: 1 day (1 wk) INT EVC

MACRDPATIIOLCGY

THE FQlJ.,CIWIJ>X; MACRDSOOPIC OBSERVATIONS WERE MADE


-------------------------------------------------------END OF PUP------------------------------------------------------------------

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N ..... ..... w

_.---...._

PAC905-01/ll

PERCHLOROETHYLENE: MIJLTIGENERATION IN!W.ATION STUDY IN THE RAT

INDIVIDUAL ANIMAL Jli\TA SUPPLEMENT

APPENDIX 26C

PATHOLOGY - F2C PUPSGROUP: 4 OOSE: 1000 ppn

LITTER: 246

LITTER SUMMARY PUP SEX: BODY CLIN FATE DATE P.M. DATE IADID wr OBS

A F 6.0 ABN INT EVC 06/05/93 ABN 06/05/93B M *DISCARDED 10/05/93 c M DISCARDED 10/05/93 D M DISCIIRDED 10/05/93E M DISCARDED 10/05/93F F DISCARDED 10/05/93G M DISCARDED 10/05/93H M DISCIIRDED 10/05/93I F DISCARDED 10/05/93J F DISCARDED 10/05/93K M DISCARDED 10/05/93L M DISCARDED 10/05/93M M DISCARDED 10/05/93

("")

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"'.....

N........N

·-._/

PAC905-01/ll

PERC!IT1JROETIIYLENE: l1!JLTIGENERATION INHALATION STUDY W THE RAT

INDIVIlXIAL J\Nlli\L DATA SUPPLEMENT

APPENDIX 26C


roSE: 1000 PJlll PATHOLOGY - F2C PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLlli OBS

FATE Jl.\TE P.M. Jl.\TE IAD

("') -1

' ....... "tl ....... ~ 0 \0 ......

N,_. ,_. ,_.

A B c D E F G H I J

M M F M F F F F F M

LOST DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

29/05/9329/05/9329/05/9329/05/9329/05/9329/05/9329/05/9329/05/9329/05/9329/05/93

.~.

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION IN!lALATION STUDY IN THE RAT

INDIVIDUAL ANlMAL IWrA SUPPLEMENT

APPENDJX 26C

PATHOLOGY - F2C PUPSGROUP: 4 !XlSE: 1000 ppn

LI1TER: 243

LITTER SUMMARY

PUP SEX BODY OLIN FATE ll'ITE P.M. ll'ITE IliD ID wr OBS

A M DISCARDED 10/05/93B F DISCARDED 10/05/93c M DISCARDED 10/05/93D F DISCARDED 10/05/93E M DISCARDED 10/05/93F F DISCARDED 10/05/93 G M DISCARDED 10/05/93H M DISCARDED 10/05/93 I M DISCARDED 10/05/93J M DISCARDED 10/05/93K M LOST 10/05/93

n -i ......_ "0 ....._..,. 0

"' ....,

N ..... ..... 0

Pi\C905-0l/11

PERCHLOROETHYLENE: Ml.JLTIGENERATION INHALATION STUDY lli THE RAT

INDIVmlAL ANM\L 1:>\TA SUPPLEMENT

.APPENDIX 26C

PATHOLOGY - F2C PUPS GROUP: 4

LI'l'rER: 242 IXlSE: 1000 ppn

LITTER SUMMARY

PUP ID

SEX BODY wr

CLlli OBS


A B c D E F G H I J K L M N

M M M M F F M F F F M F F F

5.4 ABN lliT EVC DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED LOST LOST LOST

07/05/93 11/05/93 11/05/93 11/05/9311/05/93 11/05/9311/05/93 11/05/9311/05/93 11/05/9311/05/9311/05/9311/05/93 11/05/93

NAD 07/05/93

-------------------------------------------------------END OF PUP------------------------------------------------------------------

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P.I\C905-01/ll

PERCHI.ORDE'l'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXJAL ANlli\L U\TA SUPPLEMENT

.1\PPENDIX 26C

PATHOLOGY - F2C PUPSGROUP: 4 DJSE: 1000 ppn

LITTER: 241

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IADm wr OBS

A M LOST 08/05/93B M LOST 08/05/93

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N ..... 0 Cl:>

~

P.AC905-0l/ll


INDIVI!JUAL 1\NlM,\L DATA SUPPLEMENT

APPENDIX26C

PATHOLOGY - FZC PUPSGROUP: 4 DJSE: 1000 ppn

LITTER: 240


A M DISCARDED 09/05/93B M DISCARDED 09/05/93c M DISCARDED 09/05/93 D M DISCARDED 09/05/93E M DISCARDED 09/05/93F M DISCARDED 09/05/93 G F DISCARDED 09/05/93H M DISCARDED 09/05/93I F DISCARDED 09/05/93J M DISCARDED 09/05/93K F DISCARDED 09/05/93L M DISCARDED 09/05/93M F LOST 09/05/93

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....."'0....,

PAC905-0l/11

PERCHLOROETHYLENE: MJLTIGENERATION INHALATION STUDY IN THE RAT

INDlVI!Xli\L ANlMAL DATA SUPPLEMENT

APPENDIX 26C

PATHOLCGY - FZC PUPSGROUP: 4 OOSE: 1000 PJ:IllLI'l"'E'R: 238

LITTER SUMMARY

PUP SEX BODY CLIN FATE IlliTE P.M. IlliTE IADID wr OBS

A M DISCARDED 10/05/93B F DISCARDED 10/05/93c F DISCARDED 10/05/93D M DISCARDED 10/05/93 E F DISCARDED 10/05/93F F DISCARDED 10{05/93G M DISCARDED 10/05/93 H F DISCARDED 10/05/93

" --;

• ....... "'0 ....... 0 """ ID ......

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PAC905-0l/ll

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN TilE RAT

INDI\IIIXJAL .ANIMAL DATA SUPPLEMENT


OOSE: 1000 PJIIl

APPENDIX 26C

PATHOLOGY - F2C PUPS

PUP ID

SEl( BODY wr

CLIN OBS

LITTER

FATE

SUMMARY

DATE P.M. DATE IIID

""' -l,..... ........, .........,. 0 1.0 ......

"' .... 0 01

A B c D E F G H I

F F M F F F F F F

DISCARDED DISCARDED DISCARDEO DISCARDED DISCARDEO DISCARDEO DISCARDEO LOST LOST

09/05/9309/05/9309/05/9309/05/9309/05/9309/05/9309/05/9309/05/9309/05/93

PAC905-0l/ll

PERCHLOBDETliYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXJAL ANlM!IL DATA SUPPLEMENT

.APPEND1X 26C

PATHOLOGY - FZC PUPSGROUP: 4 IXJSE: 1000 ppn

LITI'ER: 236

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE lADID wr OBS

A M DISCi\RDED 09/05/93B M DISCi\RDED 09/05/93c F DISCAJIDED 09/05/93D F DISCi\RDED 09/05/93 E M DISCAJIDED 09/05793F F DISCi\RDED 09/05/93G F DISCAJIDED 09/05/93H M DISCi\RDED 09/05/93 I M DISCi\RDED 09105793 J F DISCi\RDED 09/05/93K F DISCi\RDED 09/05/93L M DISCi\RDED 09/05/93M M DISCi\RDED 09/05/93 N M DISCi\RDED 09705793 0 F DISCi\RDED 09/05/93p M DISCAJIDED 09/05/93

" -l , ...... ...... " .., 0 <.0 ....,

N ..... 0 ..,

PAC905-0l/ll


INDlVIIXIAL .ANlMAL DATA SUPPLEMENT

APPENDIX 26C


!XJSE: 1000 ppnPATHOLOGY' - F2C PUPS

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS

FATE IWI'E P.M. IWI'E lAD

A B c D E F G H I

M M F M F M M M F

DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

29/05/9329/05/93 29/05/93 29/05/93 29/05/93 29/05/9329/05/9329/05/93 29/05/93

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N ..... 0 w

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PAC905-0l/ll


INDIVIIXJAL AN1MIIL lliiTA SUPPLEMENT

APPENDIX 26C

PAl'HOLOGY - F2C PUPSGROUP: 4 DJSE: 1000 ppn

LITI'ER: 232

LITTER SUMMARY

PUP SEX BODY CLIN FATE IlliTE P.M. IlliTE IADID wr OBS

A M DISCARDED 09/05/93B M DISCARDED 09/05/93c M DISCARDED 09/05/93D F DISCARDED 09/05/93E M LOST 09/05/93"-1 ,....-...

-o-...""'0\0....,

N

0N

~

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PAC905-01/11

PERCHLOROETHYLENE: MllLTIGENERATION INHALATION STUDY lN THE RAT

INDIVIDUAL .1\NlMAL DATA SUPPLEMENT

APPENDIX26C

PATHOLOGY - FZC PUPS GROUP: 4

LI'ITER: 231 !XlSE: 1000 ppn

LITTER SUMMARY

PUP ID

SEX BODY wr

CLlN OBS


A B c D E F G H I J K L M N

M M F M M M F F F F F F F F

6.2 6.5

ABN ABN

INT EVC INT EVC DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED LOST

07/05/93 07/05/93 11/05/9311/05/9311/05/9311/05/9311/05/93 11/05/93 11/05/9311/05/9311/05/9311/05/9311/05/93 11/05/93

NAD NAD

07/05/9307/05/93

-------------------------------------------------------END OF PUP------------------------------------------------------------------

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P11C905-01/ll

PERCHLOROETHYLENE: MIJLTIGENERATION IN!lALI\TION STUDY IN THE BAT

INDIVII:UAL AN1M\L DATA SUPPLlliENT

APPENDIX 26C

PATHOLCGY - F2C PUPS GROUP: 4 !XlSE: 1000 ppn

PUP ID: 247/A SEX: M ON STUDY: 1 day (1 wkl INT EVC

MACROPATHOLCGY

GENERt\1.. AIJTOLYSIS

-------------------------------------------------------END OF PUP------------------------------------------------------------------

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PAC905-0l/ll

PERCHLORDETIIYLENE: MULTIGENERATION INHALATiON STUDY IN THE RAT

INDlVIIX.IAL ANlMAL Jl.\TA SUPPLEMENT

.APPEND1X 26C

PATHOLOGY - F2C PUPSGROUP: 4 OOSE: 1000 IJ!IllLITI'ER: 248

LITTER SUMMARY

PUP SEX BODY CLIN FATil DATE P.M. ~.'rE IADID wr OBS

A M DISCARDED 09/05/93B M DISCARDED 09/05/93c F DISCARDED 09/05/93D M DISCARDED 09/05/93E M DISCARDED 09/05/93F M DISCARDED 09/05/93

·...._.-·



APPENDIX 27

CORPORA LUTEA AND IMPLANTATION SITE COUf'iJ'S - F1 FFMALES

Key:

Missing record D Dead

The corpora lutea and implantation sites for the A and B litters could not be distinuished and calculations of % pre- and % post-implantation loss were therefore meaningless.

Group 2 females were not evaluated.

CTL/P/4097 - 2117

(

(



APPENDIX 271-/

GROUP 1ANIMAL NUMBER OF NUMBER OFNUMBER CORPORA LUTEA IMPLANTATION SITES

25 26 26 27 27 19 28 26 229 26 20 30 22 231 19 232 25 17 33 D 34 25 25 35 27 24 36 29 27 37 27 17 38 27 20 39 28 23 40 30 30 41 34 2942 29 15 43 27 25 44 22 24 45 28 26 46 29 19 47 28 21 48 23 18

{~l'/hz

I<22 ll

l'l..~ 9- I')

JJ51- '"'l'l.

q-.,...,

i\<\I])

'I1

I(

i~ 1311,oII...qt, :i'"~:.~~

CTL/P/4097 - 2118

(

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.



APPENDIX 27 - ' '

i!GROUP 3 ANIMAL NUMBER OF NUMBER OF NUMBER CORPORA LUTEA IMPLANTATION SITES

121 26 26 122 D123 D124 29 25 125 21 19 126 31 23 127 20 19 128 27 23 129 21 17. 130 31 17 131 36 14 132 27 25 133 24 17 134 25 16 135 31 22 136 26 22 137 38 16 138 31 18 139 26 13 140 26 25. 141 D 142 143'"'144

26 19 27

23,1718

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ir~ ;.:..J • c

j'::';'.,l

2s (~

'iSat· ' ~ '

e:;SIaaa2S2SIS8S

-~.!. e~.; ~.. "~"--. ~•-.•j;"'''

;;. ;.'f~· .

'' CTL/P/4097 - 2119

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APPENDIX 27

GROUP 4 ANIMAL NUMBER OF NUMBER OF NUMBER CORPORA LUTEA IMPLANTATION SITES

169 17 22 170 23 10171 26 22 172 24 21 173 174

3424

516

175 25 21 176 23 18 177 27 13 178 179 24 13 180 24 23 181 29182 183

12D

21

184 D185 D 186 187 188

252521

14 13;15

189 28 25 190 29 12 191 26 16 192 15 17.

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CTL/P/4097 - 2120 r. - . " ~· . '

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C905-0l/ll THE RAT OOIVIIXIAL SUPPLEMENT …'i\c905-0l/ll perchlordethylene: mjjltigeneration...

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Transcript of C905-0l/ll THE RAT OOIVIIXIAL SUPPLEMENT …'i\c905-0l/ll perchlordethylene: mjjltigeneration...