Biomedical Imaging Using a Barcode ScannerBy: Nidhi Khurana Rajesh Satpathy

Challenge in biomedical imaging

• Picture of current biomedical imaging system

Challenge: Can we build a low cost biomedical imaging system?

Wojtkowski, M., Applied Optics 49, D30-D61, 2010.

Challenge in biomedical imaging

• Picture of current biomedical imaging system

Challenge: Can we build a low cost biomedical imaging system?

Wojtkowski, M., Applied Optics 49, D30-D61, 2010.

Challenge in biomedical imaging

• Picture of current biomedical imaging system

Challenge: Can we build a low cost biomedical imaging system?

Use a barcode scanner

Wojtkowski, M., Applied Optics 49, D30-D61, 2010.

Near infrared light

Depth scanning

http://cdn.wn.com/pd/dc/9d/cfc0915c804ff4dbb70ccee3feed_grande.jpg

Cross sections

Optical Coherence Tomography (OCT)

Galvonometer

Barcode Scanner

Barcode Scanner

Barcode Scanner

• 2 rows of 640 photon receptors (sensors)

• Sensors

– Aligned linearly

– Measure the light intensity

• Information sent to a processing system

– Light intensity translates into an image

Barcode Scanner Versus CCD Camera

Barcode Scanner Versus CCD Camera

Ratio of pixel size to amount of total light received by the pixel

Pixel size (µm)

Barcode scanner

CCD

Specified pixel separation and focal length affecting image resolution

Specified pixel separation and focal length affecting image resolution

Specified pixel separation and focal length affecting image resolution

Specified pixel separation and focal length affecting image resolution

He-Ne

SLED

IS90/10

L2M4

Scan Mirrors

Array Detector

PBS

M2

M1

M5

L3L1

PC

PC

Sample

M3

Experimental Setup

Spectrometer Barcode Scanner

Spectrometer

1 mm

Achene

Achene Cross sections

Achene

Barcode scanner in vivo image of achene

Microscopic image of strawberry

1 mm

Cell structure

1 mm

Possible necrotizing tissue

Void channel

1 mm

Comparison of CCD and Barcode ScannersConclusion

CCD Camera Barcode Scanner

• High resolution • Cheap

• High sensitivity

• Efficient

• Easy to use

CCD Camera Barcode Scanner

• Expensive

• Complex circuitry

• Slower image acquisition

• Low refresh rate

Pros

Cons

Future Experiments

Mobilization to real device that can be used in hospitals.

Acknowledgement

Dr. Ping Yu, Associate Professor of Physics,

University of Missouri-Columbia

Dr. H.R. Chandrasekhar, Professor of

Physics, University of Missouri-Columbia