Atomic Structure Discovered for a Sodium Channel That Generates Electrical Signals

in Living Cells AND

Biologists Identify New Strategy Used by Bacteria During Infection

Laura Isabel Gómez RivasMedicine Student

Medellín, ColombiaUPB

2011

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INTRODUCTIONVoltage-dependent sodium channels,

regulate many physiological functions

and multiple mutations cause diseases in

them

The bacterium have a strategy for infection, it was discovered how the

bacterum modify healthy cells, the study was conducted using

the Legionella Neumophila bacterium

Atomic Structure Discovered for a Sodium Channel That Generates Electrical Signals

in Living CellsScience Daily July 13,

2011

Atomic Structure Discovered for a Sodium Channel That Generates Electrical Signals in Living Cells

Science Daily July 13, 2011

Sodium channels are pores in the membranes of

excitable cells such as brain nerve cells or beating

heart cells that this emit electrical signals.

Sodium channels are important molecules

because they regulate a wide range of physiological

activities.

Atomic Structure Discovered for a Sodium Channel That Generates Electrical Signals in Living Cells

Science Daily July 13, 2011

Mutations in voltage-gated sodium channels underlie

inherited forms of epilepsy, migraine headaches, heart

rhythm disturbances, periodic paralysis, and some pain

syndromes

The symptoms of these disorders often stem from

faulty electrical signals between cells.

Some nerve toxins, such as scorpion stings or hazardous algal blooms, disrupt sodium

channels

Atomic Structure Discovered for a Sodium Channel That Generates Electrical Signals in Living Cells

Science Daily July 13, 2011

The researchers have already spotted intriguing molecular movement, such as rolling motions of some functional parts of the sodium channel

molecule and their connectors.

Know how form affects function in sodium channels could lead to many new ideas from scientists around the world on designing

drugs to home in on critical areas of the sodium channel molecule.There is a lot of interest in drug design based on the structure of

this molecule and its binding sites

OBSERVATION

This news is a clear example of the rapid pace leading research to understand

mechanisms of microbial functioning. I think this type of study, long-term can be

significantly to the treatment of many diseases curable

 

Biologists Identify New Strategy Used by Bacteria

During InfectionScience Daily July 13,

2011

Biologists Identify New Strategy Used by Bacteria During Infection

Science Daily july 13, 2011

At Purdue University identified a new way in

which the bacteria hijack healthy cells

during infection. That we know this could provide a target for

new antibiotics.

Biologists Identify New Strategy Used by Bacteria During Infection

Science Daily july 13, 2011

The Legionella pneumophila infection has Needs delivery of

hundreds of proteins in host cells that alter various functions to convert the hostile

natural for the bacterial replication, for this reason the bacterium was used

to study.

Legionella pneumophila

Biologists Identify New Strategy Used by Bacteria

During InfectionScience Daily july 13, 2011

The researchers found the enzyme that reverses or

stops SIDD processes in the cell. The activity of this enzyme is successful

because the pathogen knows how information is

transmitted in our cells and amplify signals from some

other blocks in order to evade the immune system

and prevent the cells defend themselves, creating

resistance.

Enzyem acting on healthy cell

OBSERVATION

Studies that opens the doors to development of new drugs, they are welcome in modern medicine, because drugs are an important foundation for healing, this discovery opens up possibilities for new therapies to a disease like the pneumonia.

  

MEDICAL UTILITY

research that contribute to modern medicine as the new

invention of drugs are very important and can revolutionize

treatments to various diseases

MEDICAL UTILITY

The bacterial infections are of great importance

throughout the world because they are very

frequent, discover some mechanisms to infect certain bacteria can

reduce their impact and contribute to better

treatments.

MEDICAL UTILITY

When the science progresses,

lengthen the years of people's lives, so also the progress should involve a

healthy life

MEDICAL UTILITY

The investigation is an important field in the medicine because it

allows to quantify and to qualify variables and also it allows other actions for reaching the medicine, for that, studies like this helps to improve ways to

treat diseases and health.

BIBLIOGRAPHY

 

 

· · Biologists Identify New Strategy Used by Bacteria During Infection. Science Daily [online]. July 13, 2011 [ref. July 14, 2011]. Available online <http://www.sciencedaily.com/releases/2011/07/110712152206.htm>   

 

· •Atomic Structure Discovered for a Sodium Channel That Generates Electrical Signals in Living Cells. Science Daily [online]. July 13, 2011 [ref. July 14, 2011]. Available online <http://www.sciencedaily.com/  

THANKS!