Bioengineering & Biotechnology

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Contents

Biomedical Engineering ....................................3

Bio MEMS, NEMS & Materials ........................14

Biomedical Imaging ........................................19

Biophysics ......................................................20

Biotechnology ................................................21

General Textbooks ..........................................26

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Biomedical Engineering

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Coming Soon!

Biofluid MechanicsThe Human Circulation, Second EditionKrishnan B. ChandranUniversity of Iowa, Iowa City, USA

Alit P. YoganathanGeorgia Institute of Technology, Atlanta, USA

Stanley E. RittgersUniversity of Akron, Ohio, USA

Heart failure and neurological deficits due to arte-rial diseases are the greatest causes of death indeveloped countries. Hence, fluid mechanicaleffects on the development and progression of thedisease are of fundamental importance toresearchers. In addition, the design and develop-ment of circulatory implants such as artificial heartvalves, ventricular assist devices, and vasculargrafts require knowledge of blood flow past thesedevices.Examining the biodynamics of heart disease, thisthoroughly updated edition of BiofluidMechanics: The Human Circulation reviews thefluid mechanical analysis of blood flow in humanarterial circulation. It focuses on the developmentand progression of arterial disease as well as thetools and technology at the cutting edge of treat-ment. Applying the theory of fluid mechanicalprinciples in human circulation, the text evaluatesthe design and development of circulatoryimplants such as artificial heart valves, ventricularassist devices, and vascular grafts. This editionincludes a new chapter on simulations.

Pedagogical Features:

• Draws on the work of three outstandingresearchers and academics in biofluidmechanics

• Incorporates updates in every chapter • Includes significant new illustrations • Offers additional problems and examples • Presents an entirely new chapter on computational simulations

Solutions manual available with qualifying course adoption

Abridged Contents: FLUID AND SOLID MECHANICS AND CARDIOVASCULAR PHYSIOLOGY

Fundamentals of Fluid MechanicsIntrinsic Fluid PropertiesHydrostaticsMacroscopic Balances of Mass and MomentumMicroscopic Balances of Mass and MomentumBernoulli EquationDimensional AnalysisFluid Mechanics in a Straight TubeBoundary Layer Separation Introduction to Solid MechanicsIntroduction to Mechanics of MaterialsAnalysis of Thin-Walled Cylindrical Tubes Analysis of Thick-Walled Cylindrical TubesViscoelasticityCardiovascular PhysiologyHeartCardiac ValvesSystemic CirculationCoronary CirculationPulmonary Circulation and Gas Exchange in theLungsCerebral and Renal CirculationsMicrocirculationBIOMECHANICS OF THE HUMAN CIRCULATION

Rheology of Blood and Vascular Mechanics Rheology of Blood Vascular Mechanics Static and Steady Flow Models Hydrostatics in the Circulation Applications of the Bernoulli Equation Unsteady Flow and Nonuniform GeometricModels

Native Heart Valves CARDIOVASCULAR IMPLANTS, BIOMECHANICAL MEASUREMENTS, ANDCOMPUTATIONAL SIMULATIONS

Prosthetic Heart Valve Dynamics Vascular Therapeutic TechniquesFluid Dynamic Measurement Techniques Computational Fluid Dynamic Analysis of theHuman Circulation

INDEXMarch 2012, 452 pp.ISBN: 978-1-4398-4516-5, £66.99



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Coming Soon!

Analysis and Application of AnalogElectronic Circuits to BiomedicalInstrumentationSecond EditionRobert B. NorthropUniversity of Connecticut, Storrs, USA

Biomedical engineering is an interdisciplinary science characterized bynon-stationary signals acquired in the course of diagnosis and research andcomplex, non-linear, cross-coupled, time-variable systems from which thesesignals arise.Covering such technologies as ECG, EEG, EMG,and ERG along with heart and breath sounds,blood pressure, and tomographic images,Analysis and Application of Analog ElectronicCircuits to Biomedical Instrumentation, SecondEdition provides a ready source of information onhow to understand and design signal conditioningsystems using analog integrated circuits. In thisedition, Robert B. Northrop, a well-establishedtextbook author, has updated and revised the textsubstantially. The book now features three newchapters that address power amplifiers and theirapplications to biomedical instruments, wirelesspatient monitoring, and RFID, GPS, and ultrasonictags used in ecological research.


• Updates and revises all material in the text• Features three new chapters addressingpower amplifiers, wireless patient monitoring,and RFID, GPS, and ultrasonic tags

• Provides new end-of-chapter problems andexamples

• Includes an extensive glossary


Abridged Contents: Sources and Properties of Biomedical SignalsSources of Endogenous Bioelectric SignalsNerve Action PotentialsMuscle Action PotentialsProperties and Models of SemiconductorDevices Used in Analog Electronic Systemspn Junction DiodesMidfrequency Models for BJT BehaviorThe Differential AmplifierDA Circuit ArchitectureCommon-Mode Rejection Ratio

CM and DM Gain of Simple DA Stages at HighFrequenciesInput Resistance of Simple Transistor DAsGeneral Properties of Electronic, Single-LoopFeedback SystemsClassification of Electronic Feedback SystemsSome Effects of Negative Voltage FeedbackFeedback, Frequency Response, and AmplifierStabilityReview of Amplifier Frequency ResponseWhat Is Meant by Feedback System StabilityOperational Amplifiers and ComparatorsThe Ideal Op AmpPractical Op AmpsGain-Bandwidth Relations for Voltage-FeedbackOAsIntroduction to Analog Active FiltersActive Filter ApplicationsTypes of Analog Active FiltersElectronically Tunable AFsInstrumentation and Medical IsolationAmplifiersNoise and the Design of Low-Noise SignalConditioning Systems forBiomedical ApplicationsDescriptors of Random Noise in BiomedicalMeasurement SystemsPropagation of Noise Through LTI FiltersNoise Factor and Figure of AmplifiersCascaded Noisy AmplifiersDigital InterfacesModulation and Demodulation of BiomedicalSignalsPower Amplifiers and Their Applications inBiomedicineRFID Tags, GPS Tags, and Ultrasonic TagsUsed in Ecological ResearchExamples of Special Analog Circuits andSystems Used in Biomedical InstrumentationAppendixGlossaryBibliography and Recommended Reading

March 2012, 588 pp.ISBN: 978-1-4398-6669-6, £76.99



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Biomedical Engineering PrinciplesSecond EditionArthur B. Ritter, Vikki Hazelwood, Antonio Valdevit, and Alfred N. Ascione

“ … not only an in-breadth overview on current BME fields, but also an in-depth analysis of specific selected topics that are supported by appropriatemathematical models, equations, quantitative data charts and tables."

—Biomedical Engineering Online

" … an excellent textbook for a class."—IEEE Engineering in Medicine and Biology Magazine

" … well-illustrated with figures, schemes, various plots, and mathematicalequations."—G. Ya. Wiederschain, Doctor of Biological Science, Moscow State University, Russia

Biomedical Engineering Principles, SecondEdition provides a solid, accessible grounding tothis rapidly advancing field. Acknowledging thevast range of backgrounds and prior educationfrom which the biomedical field draws, theorganization of this book lends itself to a tailoredcourse specific to the experience and interests ofthe student.Divided into four sections, the book begins withsystems physiology, transport processes, cellphysiology, and the cardiovascular system. Part Icovers systems analysis, biological data, and mod-eling and simulation in experimental design,applying concepts of diffusion and facilitated andactive transport. Part II presents biomedical signalprocessing, reviewing frequency, periodic func-tions, and Fourier series as well as signal acquisi-tion and processing techniques.Part III discusses practical applications of biome-chanics, focusing on the mechanical and structur-al properties of bone, musculoskeletal, and con-nective tissue with respect to joint range, loadbearing capacity, and electrical stimulation. Thefinal part highlights capstone design, explainingdesign perspectives for living and nonliving sys-tems, the role of the FDA, and the project time-line from inception to proof of concept.


• Includes new chapters on capstone design inbiomedical engineering and entrepreneurship

• Contains new coverage of systems biologyand computational biology

• Provides revised and updated chapters onthe emerging field of tissue engineering

• Offers extensive examples and in-chapterproblems

Contents:

Introduction: Modeling of PhysiologicalProcesses

Cell Physiology and Transport

Principles and Biomedical Applications ofHemodynamics

A Systems Approach to Physiology

The Cardiovascular System

Biomedical Signal Processing

Signal Acquisition and Processing

Techniques for Physiological Signal Processing

Examples of Physiological Signal Processing

Principles of Biomechanics

Practical Applications of Biomechanics

Biomaterials

Principles of Biomedical Capstone Design.Unmet Clinical Needs

Entrepreneurship: Reasons why Most GoodDesigns Never Get to Market

An Engineering Solution in Search of aBiomedical Problem to Solve

Tissue Engineering

Future Trends in BME

May 2011, 540 pp.ISBN: 978-1-4398-1232-7, £63.99



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6

New Edition of a Bestseller!

Basic Transport Phenomena in Biomedical EngineeringThird EditionRonald L. FournierUniversity of Toledo, Ohio, USA

Encompassing a variety of engineering disci-plines and life sciences, the very scope andbreadth of biomedical engineering presentschallenges to creating a concise, entry level textthat effectively introduces basic concepts with-out getting overly specialized in subject matteror rarified in language. Basic TransportPhenomena in Biomedical Engineering, ThirdEdition meets and overcomes these challengesto provide beginning students with the founda-tional tools and the confidence they need toapply these techniques to problems of evergreater complexity.

Bringing together fundamental engineering andlife science principles, this highly accessible textprovides a focused coverage of key momentumand mass transport concepts in biomedical engi-neering. It offers a basic review of units anddimensions, material balances, and problem-solving tips, and then emphasizes those chemi-cal and physical transport processes that haveapplications in the development of artificial andbioartificial organs, controlled drug delivery sys-tems, and tissue engineering. The book alsoincludes a discussion of thermodynamic con-cepts and covers topics such as body fluids,osmosis and membrane filtration, physical andflow properties of blood, solute and oxygentransport, and pharmacokinetic analysis. It con-cludes with the application of these principles toextracorporeal devices as well as tissue engineer-ing and bioartificial organs.

Designed for the beginning student, this textprovides a quantitative understanding of theunderlying physical, chemical, and biologicalphenomena involved.


• Offers mathematical models using the “shellbalance” and compartmental approaches

• Includes numerous examples with a discussionof the numerical methods used to solve theproblems

• Supplies illustrations with homework problemsat the end of each chapter

• Contains an extensive bibliography of theresearch literature that supports the materialin the text


Contents:

Introduction

A Review of Thermodynamic Concepts

Physical Properties of the Body Fluids and theCell Membrane

The Physical and Flow Properties of Blood

Solute Transport in Biological Systems

Pharmacokinetic Analysis

Extracorporeal Devices

Tissue Engineering

Bioartificial Ogans

Index

August 2011, 483 pp.ISBN: 978-1-4398-2670-6, £44.99





New!

Introduction to Biomedical Engineering TechnologySecond EditionLaurence StreetRosedale, British Colombia, Canada

Medical devices are often very complex, butwhile there are differences in design from onemanufacturer to another, the principles of oper-ation and, more importantly, the physiologicaland anatomical characteristics on which theyoperate are universal. Introduction toBiomedical Engineering Technology, SecondEdition explains the uses and applications ofmedical technology and the principles of med-ical equipment management to familiarize stu-dents with their prospective work environment.

Written by an experienced biomedical engineer-ing technologist, the book describes the techno-logical devices, various hardware, tools, and testequipment used in today’s health-care arena.Photographs of representative equipment; thetechnical, physiological, and anatomical basisfor their function; and where they are common-ly found in hospitals are detailed for a widerange of biomedical devices—from defibrillatorsto electrosurgery units.

This accessible text supplies an essentialoverview of clinical equipment and the devicesthat are used directly with patients in the courseof their care for diagnostic or treatment purpos-es. The author’s practical approach and organi-zation, outlining everyday functions and appli-cations of the various medical devices, preparesstudents for situations they will encounter onthe job.


• Incorporates real-life examples of the workthat biomedical engineering technologists do

• Contains examples, illustrations, and end-of-chapter questions to test students’understanding

• Provides appendices with useful informationsuch as normal medical values, a list of regulatory bodies, internet resources, andinformation on training programs

• Includes a 16-page grayscale insert with photographs of real-life equipment problems


Contents:

IntroductionDiagnostic Devices: Part OneDiagnostic Devices: Part TwoDiagnostic Devices: Part ThreeDiagnostic ImagingTreatment Devices: Part OneTreatment Devices: Part TwoTreatment Devices: Part ThreeBiomedical Engineering Technologist (BMET) WorkTesters and ToolsBatteries, Radiation, and ComputersTechnology ManagementAppendix A: Normal ValuesAppendix B: Regulations and StandardsAppendix C: Biomedical EngineeringTechnology Programs in the United States and CanadaAppendix D: Biomedical AssociationsAppendix E: Devices and ManufacturersAppendix F: Test Equipment ManufacturersAppendix G: Bibliography and InternetResourcesIndex

October 2011, 391 pp. ISBN: 978-1-4398-6058-8, £56.99





Biomechanics of the Upper LimbsMechanics, Modeling and Musculoskeletal Injuries,Second EditionAndris FreivaldsPennsylvania State University, University Park, USA

Over the past two decades, the growth in com-puter-related jobs has led to considerable increasein the number of work-related musculoskeletal dis-orders in the upper limbs. Now in its second edi-tion, Biomechanics of the Upper Limbs:Mechanics, Modeling and MusculoskeletalInjuries offers vital information and tools toimprove analysis of external forces and their effectson the human body. This can help future ergono-mists better understand job stressors and the rolethey play in the development of disorders.Using the author’s medical and engineeringexpertise to distill essential subject matter anduseful technical data, this comprehensive textexplores the biomechanics of the upper limbs andthe motor control system and the structure andphysiology of the human musculoskeletal andneuromuscular systems. It examines recentresearch findings and solutions to variousergonomic problems and presents models of var-ious components of the neuromuscular systems,as well as larger systems in the upper limbs. It alsoexplores the risk factors for disorders and toolsused to identify their causes.


• Includes figures, tables, problems, and examples

• Contains end-of-chapter questions to testassimilation

• Features downloadable PowerPoint® slides,sample exams, and other background material on a supporting website

• Presents ample references to enhance furtherstudy

Instructor’s manual available upon qualifying course adoption

Abridged Contents

Introduction to BiomechanicsWhat Is Biomechanics?Basic ConceptsCoordinate SystemsForce Vector AlgebraStatic EquilibriumAnthropometry and Center of MassDeterminationFrictionDynamicsStructure of the Musculoskeletal SystemGross Overview of MovementsSkeletal SystemMechanical Properties of BoneSoft Connective TissueJointsNeuromuscular Physiology and MotorControlIntroduction to MusculatureStructure of MuscleBasic Cell PhysiologyNervous SystemExcitation–Contraction SequenceMotor UnitsBasic Muscle Properties (Mechanics)Energy, Metabolism, and Heat ProductionReceptorsReflexes and Motor ControlModeling of Muscle MechanicsLaplace Transforms and Transfer FunctionsViscoelastic TheoryHill’s Muscle ModelsFrequency AnalysisFrequency Analysis of Passive MuscleModels of the Upper LimbsMusculoskeletal Disorders and Risk FactorsInstrumentationJob and Worksite AnalysisHand ToolsThe Office EnvironmentFebruary 2011, 564 pp.

ISBN: 978-1-4200-9119-9, £76.99





Biology for EngineersArthur T. JohnsonUniversity of Maryland, College Park, USA

Biology is a critical application area for engineer-ing analysis and design, and students in engi-neering programs must be well-versed in thefundamentals of biology as they relate to theirfield. Biology for Engineers is an introductorytext that emphasizes concepts, technology, andthe utilization of living things. Classroom-testedat the University of Maryland, this comprehen-sive text introduces concepts and terminologyneeded to understand more advanced biologyliterature. The book explores scientific principles relevantto biology that all engineers must know. It dis-cusses biological responses from the perspectiveof a broad range of fields such as psychology,human factors, genetics, plant and animal phys-iology, imaging, control systems, actuary, andmedicine. It examines the scaling of biologicalresponses and attributes and presents a classifi-cation of different types of applications relatedto biological systems. The text brings togetherall of the concepts one needs to understand therole of biology in modern technology.


• Provides ample instruction on the basics ofphysics, chemistry, mathematics, and engineering

• Minimizes unnecessary memorization of connections and classifications

• Presents practical, detailed examples

• Emphasizes the interactions between a biological unit and its physical, chemical, and biological environments

• Presents tables of useful information nearlyimpossible to find elsewhere


Abridged Contents:

INTRODUCTIONScience and EngineeringScientific MethodMathematical ModelingBiological EngineeringExpectations for Biological EngineersAbout PredictionsAbout This BookQuestionsPRINCIPLES FROM THE SCIENCESPrinciples of PhysicsEffort and Flow VariablesBalancesStates of MatterEquivalence of Work and EnergyFree EnergyDisorder and EntropyHeat TransferMovement of MaterialsFluid MechanicsSolid MechanicsElectricityTemperature EffectsQuestionsPrinciples of ChemistryPeriodic Nature of ElementsChemical BondingChemical EquilibriumAcids and BasesReaction RatesCarbon ChemistryPrinciples of Mathematics and EngineeringSciencesPrinciples of BiologyRESPONSES OF LIVING SYSTEMSBiological Responses in ContextSCALING FACTORSUTILIZING LIVING SYSTEMSBiological Engineering SolutionsAPPENDICESREFERENCES

September 2010, 775 pp.ISBN: 978-1-4200-7763-6, £66.99




Essential Titles from Bestselling Author Robert B. Northrop

Signals and Systems Analysis in Biomedical EngineeringSecond EditionRobert B. NorthropUniversity of Connecticut, Storrs, USA

The first edition of this text, based on theauthor’s thirty years of teaching and research onneurosensory systems, helped biomedical engi-neering students and professionals strengthentheir skills in the common network of appliedmathematics that tied together the diverse disci-plines that comprise this field. Updated andrevised to include new material as the field hasgrown, Signals and Systems Analysis inBiomedical Engineering, Second Edition con-tinues to provide a ready source of informationon those specialized mathematical techniquesmost useful in describing and analyzing biomed-ical signals.This volume covers classical linear systems theo-ry and its applications to biomedicine. It exam-ines the important use of joint time-frequencyanalysis to characterize non-stationary physio-logical signals. It also explores the mathematicsof tomographic imaging (the Radon transform,the Fourier slice theorem, and the filtered back-projection algorithm). The book also describesthe analytical signal and the Hilbert transformand some of its biomedical applications.


• Includes new chapters on nonlinear bio-chemical systems and biochemical oscillators

• Contains a new chapter introducing complexsystems and illustrating ways to best modelthem

• Presents numerous examples that promotesound practical analysis

• Supplies an extensive glossary as well as anample listing of sources for further study

• Provides extensive appendices to supplementthe text, including “Simnon® Programs Usedin Chapters 11 and 12,” “How to Use RootLocus to Determine the Stability of SISOLinear Feedback Systems,” “Signal FlowGraphs and Mason’s Rule,” and“Computational Tools for Biomedical SignalProcessing and Systems Analysis”


Abridged Contents:Introduction to Biomedical Signals andSystemsGeneral Characteristics of Biomedical SignalsGeneral Properties of PSsReview of Linear Systems TheoryLinearity, Causality, and StationarityAnalog SystemsSystems Described by Sets of ODEsLinear System CharacterizationDiscrete Signals and SystemsStability of SystemsThe Laplace Transform and Its ApplicationsIntroductionProperties of the Laplace TransformSome Examples of Finding Laplace TransformsThe Inverse Laplace TransformApplications of the Laplace TransformFourier Series Analysis of Periodic SignalsIntroductionProperties of the FSFS ExamplesThe Continuous Fourier TransformIntroductionProperties of the CFTADC and the Sampling TheoremThe Discrete Fourier TransformIntroduction to Joint TimeFrequency Analysisof Biomedical Signals

Introduction to the Analysis of StationaryNoise, and Signals Contaminated with Noise

Basic Mathematical Tools Used in theCharacterization of Physiological Systems

Introduction to the Mathematics ofTomographic Imaging

Introduction to the Analysis of NonlinearBiochemical Systems and BiochemicalOscillators

Introduction to Complex Systems in Biologyand Medicine

GlossaryAppendices

March 2010, 654 pp.ISBN: 978-1-4398-1251-8, £66.99




Essential Titles from Bestselling Author Robert B. Northrop

Introduction to Complexity and Complex SystemsRobert B. NorthropUniversity of Connecticut, Storrs, USA

The boundaries between simple and complicat-ed, and complicated and complex system desig-nations are fuzzy and debatable, even usingquantitative measures of complexity. However,biomedical engineers, biologists, physiologists,economists, politicians, stock market specula-tors, and politicians all encounter complex sys-tems. Their success depends on their ability tosuccessfully interact with and manage a varietyof complex systems. In order not to be blind-sided by unexpected results, they need a sys-tematic, comprehensive way of analyzing, mod-eling, and simulating complex systems to pre-dict non-anticipated outcomes.In its engaging first chapters, Introduction toComplexity and Complex Systems introducesCampbell's Law, the Law of UnintendedConsequences, and the mathematics necessaryfor conversations in complex systems.Subsequent chapters illustrate concepts viacommonly studied biological mechanisms. Thefinal chapters focus on higher-level complexityproblems and introduce complexity in econom-ic systems. This text is an ideal introduction tocomplex systems for advanced students study-ing biomedical engineering, biophysics, andphysiology.


• Describes the characteristics of certain complex living systems and provides dynamic models

• Offers present-day examples to place thematerial in context

• Includes homework problems for enhancedcomprehension

Abridged Contents:

Introduction to Complexity and ComplexSystemsIntroduction to ComplexityWhy Study Complex Systems?Human Responses to ComplexityComplex Systems EngineeringChapter SummaryIntroduction to Large Linear SystemsLinearity, Causality & Stationarity L TI System Tools Impulse Response, FrequencyResponse and Real Convolution Systems Described by Large Sets of Linear ODEs Stability of Linear Systems Signal Flow Graphs and Mason's Rule Introduction to Nonlinear BiochemicalSystems and Biochemical Oscillators

Modularity, Redundancy, Degeneracy,Pleiotropy and Robustness in ComplexBiological Systems

The Evolution of Biological Complexity;Invertebrate Immune Systems

The Complex Adaptive and Innate HumanImmune Systems

Complexity in Quasispecies MicroRNAsIntroduction to Physiological ComplexityExamples of Models of Some ComplexPhysiological Systems

The Quest for Quantitative Measures ofComplexity

"Irreducible and Specified Complexity" inLiving Systems

Introduction to Complexity in EconomicSystems

Dealing with ComplexityAppendixBibliography and ReferencesGlossaryIndex

December 2010, 551 pp.ISBN: 978-1-4398-3901-0, £53.99




Biomedical Engineering Bio MEMS, NEMS, & Materials

BiomaterialsA Nano ApproachSeeram Ramakrishna,Murugan Ramalingam,T.S. Sampath Kumar, andWinston O. Soboyejo

From a multi-disciplinary point of view,Biomaterials: A Nano Approach examinesbasic concepts, various processing methodolo-gies, and techniques involved in the preparationand characterization of nanobiomaterials specif-ic to biomedical applications. Spanning their his-torical development and reviewing recentadvances in the field, it describes how basic con-cepts in nanotechnology are applied to the pro-cessing of novel nanobiomaterials, includingnanostructured metals and alloys. It discussesmaterials used for biomedical applications,including tissue engineering and drug delivery,and describes the biological and environmentaleffects of nanomaterials. Presenting illustrativeexamples, case studies, exercises, and a varietyof applications, this text offers a solid frameworkfor understanding present and future trends ofbiomaterials in human health care systems.

Contents:

Overview of Biomaterials

Basics of Human Biology

Degradation and Corrosion of Biomaterials

Failure and Tribology of Biomaterials

Nanoscale Phenomena

Metallic Biomaterials

Ceramic Biomaterials

Polymeric Biomaterials

Composite Biomaterials

Nanobiomaterials for Tissue Engineering

Glossary

Exercises

References

June 2010, 372 pp.ISBN: 978-1-4200-4781-3, £69.99

New!

UnderstandingNanomedicineAn IntroductoryTextbookRob BurgessMedical NanotechnologiesIncorporated, Richardson, Texas, USA

The application of nanotechnology to medicinehas burgeoned into a growing field, with fundingfrom the National Institutes of Health and wideinterest from all scientific sectors. UnderstandingNanomedicine: An Introductory Textbookcomprehensively covers a broad range of thera-peutic and diagnostic applications of nanotech-nology. Providing a dynamic learning experience,the book intersperses cutting-edge discoverieswith historical perspectives. Preliminarily, the textdiscusses the basic principles of nanotechnology,focusing on nanomaterials and nanoparticles.These are the sectors that hold the most promisefor the future of medicine. The book then pro-gresses to nanomedicine as it applies to currentand future society.

Contents:

Fundamentals of Nanotechnology

Nanoparticles and Hyperthermic CancerTherapeutics

Nanofiber-Based Scaffolds and TissueEngineering

Nanotechnology and Neuroscience

Nanotechnology and Surgery

Nanomatrices for Cell Culture

Nanoparticle-Based Drug Delivery

Nanodiagnostics

Government Influence on Nanotechnology

Future Concepts in Nanomedicine

February 2012, 350 pp. ISBN: 978-981-4316-38-5, £95.00






New!

An Introduction to BiomaterialsSecond EditionEdited by

Jeffrey O. HollingerCarnegie Mellon University, Pittsburgh, Pennsylvania, USA

A practical road map to the key families of bioma-terials and their potential applications in clinicaltherapeutics, Introduction to Biomaterials,Second Edition follows the entire path of devel-opment from theory to lab to practical applica-tion. It highlights new biocompatibility issues,metrics, and statistics as well as new legislation forintellectual property. Divided into four sections (Biology, Biomechanics,Biomaterials Interactions; Biomaterials Testing,Statistics, Regulatory Considerations, IntellectualProperty; Biomaterials Compositions; andBiomaterials Applications), this dramatically revisededition includes both new and revised chapters oncells, tissues, and signaling molecules in woundhealing cascades, as well as two revised chapterson standardized materials testing with in vitro andin vivo paradigms consistent with regulatoryguidelines. Emphasizing biocompatibility at thebiomaterial-host interface, it investigates cell-cellinteractions, cell-signaling and the inflammatoryand complement cascades, specific interactions ofprotein-adsorbed materials, and other inherentbiological constraints, including solid-liquid inter-faces, diffusion, and protein types. Unique in itsinclusion of the practicalities of biomaterials as anindustry, the book also covers the basic principlesof statistics, new US FDA information on the bio-materials-biology issues relevant to patent applica-tions, and considerations of intellectual propertyand patent disclosure. This comprehensive, yet manageable didacticwork is an invaluable desk reference and instruc-tional text for undergraduates. This volume is anideal text alongside A Laboratory Course inBiomaterials (p. 14).


• Includes nine completely new chapters and24 chapters extensively updated and revisedwith new accomplishments and contemporarydata

• Explains in vitro and in vivo testing paradigmsand provides numerous examples in thechapters on experimental design, laboratoryassays, and animal models

• Contains end-of-chapter questions andanswers

• Includes extensive references for furtherstudy

Abridged Contents:

Consensus Definitions, Fundamental Concepts,and a Standardized Approach to AppliedBiomaterials Sciences

Biology, Biomechanics, BiomaterialInteractions: Wound Healing BiologyCutaneous Wound Pathobiology: Raison d’etrefor Tissue EngineeringOsseous Wound HealingBiology, Biomechanics, BiomaterialInteractions: Cellular MechanicsCell and Tissue MechanobiologyBiology, Biomechanics, BiomaterialInteractions: Materials–Host InteractionsCell–Material Interactions: Fundamental DesignIssues for Tissue Engineering and ClinicalConsiderations Host Response to Biomaterials Protein Adsorption at the Biomaterial–TissueInterface

Biomaterials Testing, Statistics, RegulatoryConsiderations, Intellectual Property:Standardized Materials Testing

In Vitro Testing of Biomaterials. Assessment ofBiomaterials: Standardized In Vivo Testing

Biomaterials Testing, Statistics, RegulatoryConsiderations, Intellectual Property:Statistics Basic Principles of Statistics: Considerations forBiomaterials Engineers Therapy Development, Animal Testing, andRegulatory Issues

Biomaterials CompositionsBiomaterials ApplicationsIndex

November 2011, 644 pp. ISBN: 978-1-4398-1256-3, £48.99




Bio MEMS, NEMS & Materials

A Laboratory Course in BiomaterialsWujing XianUniversity of Illinois at Urbana-Champaign, USA

The field of biomedical engineering has vastlyexpanded in the past two decades, as reflected inthe increased number of bioengineering and bio-materials programs at universities. The growth ofthis area has outpaced the development of labo-ratory courses that allow students hands-on expe-rience, since the barriers involved in creating mul-tidisciplinary biomaterials laboratory courses arehigh. A teaching tool for instructors in biomateri-als and bioengineering, A Laboratory Course inBiomaterials is a comprehensive laboratory text-book and an ideal supplement to An Introductionto Biomaterials, Second Edition (p. 13). This volume trains students in laboratory skills,data analysis, problem solving, and scientific writ-ing and integrates a variety of principles thatinclude materials science, chemistry, biochemistry,molecular and cell biology, and engineering.Providing detailed descriptions, explanations, andillustrations of experiments, the text also includesa series of questions and answers at the end ofeach chapter to clarify concepts. Many of theexperiments presented are adapted from researchpapers to reflect the recent progress in biomateri-als and bioengineering.


• Presents detailed, step-by-step descriptions of lab procedures and explanations for theunderlying principles

• Contains user-friendly graphic illustrations forthe experiments

• Provides a series of questions and answers atthe end of each chapter to clarify conceptsand induce critical thinking

• Includes text boxes with in-depth informa-tion, case studies, and lab tips

• Offers information on equipment, reagents,and supplies for instructors

Abridged Contents:

Basic Laboratory SkillsCommonly Used Lab Equipment and SuppliesWaste DisposalLiquid TransferWeighingMaking SolutionsError AnalysisModule I. Drug Delivery: Controlled Releaseof Encapsulated Protein from PLGAEncapsulation of BSA in PLGA MicrospheresEvaluation of the Encapsulation Efficiency andthe Drug LoadControlled Release of BSA from PLGAMicrospheresEvaluation of Controlled Release ProfileQuestionsAppendix: Recipes and Sources for Equipment,Reagents, and SuppliesModule II. Natural Biomaterials: Collagen and ChitosanExtracting Acid-Soluble Type I Collagen fromBovine Calf SkinPurification of Extracted CollagenAnalysis of Collagen Extraction and Purificationby ElectrophoresisFabricating Collagen/Chitosan SpongesQuestionsAppendix: Recipes and Sources for Equipment,Reagents and SuppliesBasic Laboratory Skills II. Cell Culture andMicroscopyCell CultureExercisesModule III. Biocompatibility Testing:Cytotoxicity and AdhesionModule IV. Tissue Engineering: OrganotypicCultures of Skin EquivalentsModule V. Bioceramics: PorousHydroxyapatite CompositeAppendix: Answers

June 2009, 216 pp., Soft Cover ISBN: 978-1-4200-7582-3, £41.99





From MEMS to Bio-MEMS and Bio-NEMSManufacturing Techniques and ApplicationsMarc J. MadouUniversity of California, Irvine, USA

From MEMS to Bio-MEMS and Bio-NEMS:Manufacturing Techniques and Applicationsdetails manufacturing techniques applicable tobionanotechnology. After reviewing MEMS tech-niques, materials, and modeling, the book coversnanofabrication, genetically engineered proteins,artificial cells, nanochemistry, and self-assembly. Itdiscusses nonlithography manufacturing tech-niques with lithography-based methods. Itreviews packaging, assembly, and self-assemblyfrom ICs to DNA and biological cells. It alsoexplores selected new MEMS and NEMS process-es and materials, metrology techniques, andmodeling. Additional sections in the book explore scalinglaws, actuators, power generation, and the imple-mentation of brains in miniaturizes devices. Theauthor also reviews different strategies for makingmicromachines smarter and discusses the transi-tion out of the laboratory and into the market-placeThe third volume in Fundamentals ofMicrofabrication and Nanotechnology, ThirdEdition, Three-Volume Set, the book discusses top-down and bottom-up manufacturing methodsand explains how to use nature as a guide. It pro-vides a better understanding of how to match dif-ferent manufacturing options with a given appli-cation that students can use to identify additionalMEMS and NEMS applications.Other volumes in the set include: Solid-StatePhysics, Fluidics, and Analytical Techniques in Micro-and Nanotechnology Manufacturing Techniques forMicrofabrication and Nanotechnology.


• Focuses on applications of NEMS and MEMS

• Includes end-of-chapter problems as well asworked-out problems within the text

• Contains color illustrations throughout, exten-sive references for further reading, and a com-prehensive glossary of terms

Solutions manual, PowerPoint® lecture slides, and electronicfigures available with qualifying course adoption

Contents:

From Traditional Manufacturing toNanotechnology

Nonlithography-Based (Traditional) andLithography-Based (Nontraditional)Manufacturing Compared

Nature as an Engineering Guide: Biomimetics

Nanotechnology: Top-Down and Bottom-UpManufacturing Approaches Compared

Packaging, Assembly, and Self-Assembly

Selected Materials and Processes for MEMS and NEMS

Metrology and MEMS/NEMS Modeling

Scaling Laws, Actuators, and Power and Brains in Miniature Devices

Scaling Laws

Actuators

Power and Brains in Miniature Devices

Miniaturization Application

MEMS and NEMS Applications

June 2011, 650 pp.ISBN: 978-1-4200-5516-0, £63.99





BioMEMSScience and Engineering PerspectivesSimona Badilescu and Muthukumaran PackirisamyConcordia University, Montreal, Canada

As technological advancements widen the scopeof applications for biomicroelectromechanical sys-tems (BioMEMS or biomicrosystems), the fieldcontinues to impact many aspects of life scienceoperations and functionalities. Because BioMEMSresearch and development require the input ofexperts who use different technical languages andcome from varying disciplines and backgrounds,scientists and students can avoid potential difficul-ties in communication and understanding only ifthey possess a skill set and understanding thatenables them to work at the interface of engineer-ing and biosciences.Keeping this duality in mind throughout,BioMEMS: Science and EngineeringPerspectives supports and expedites the multidis-ciplinary learning involved in the development ofbiomicrosystems. Divided into nine chapters, itstarts with a balanced introduction of biological,engineering, application, and commercializationaspects of the field. With a focus on molecules ofbiological interest, the book explores the buildingblocks of cells and viruses, as well as moleculesthat form the self-assembled monolayers (SAMs),linkers, and hydrogels used for making differentsurfaces biocompatible through functionalization. Because BioMEMS is an application-driven field,the book also highlights the concepts of lab-on-a-chip (LOC) and micro total analysis system (�TAS),along with their pertinence to emerging point-of-care (POC) and point-of-need (PON) applications.


• Provides a concise overview of BioMEMSprinciples

• Incorporates modern applications• Covers fabrication techniques• Includes examples and problems in eachchapter

• Offers references, review questions, and casestudies to aid comprehension


Abridged Contents:IntroductionIntroduction to BioMEMSApplication AreasIntersection of Science and EngineeringEvolution of Systems Based on SizeCommercialization, Potential, and MarketSubstrate Materials Used inBioMEMS DevicesMetalsGlasses and CeramicsSilicon and Silicon-Based SurfacesPolymersBiopolymersOrganic Molecules (Functional Groups) Involvedin the Formation of Self-AssembledMonolayersBiomolecules and Complex BiologicalEntities: Structure and PropertiesAmino AcidsPolypeptides and ProteinsLipidsNucleotides and Nucleic AcidsCarbohydratesEnzymesCellsBacteria and VirusesEngineering of Bioactive SurfacesPlasma Treatment and Plasma-Mediated SurfaceModificationSurface Modifications Mediated by Self-Assembled Monolayers (SAMs)

Methods of Study and Characterization ofSurface-Modified SubstratesBiosensing FundamentalsFabrication of BioMEMS DevicesIntroduction to MicrofluidicsBioMEMS

April 2011, 368 pp.ISBN: 978-1-4398-1699-8, £63.99





Biomedical MicrosystemsEllis MengUniversity of Southern California, Los Angeles, USA

Poised to dramatically impact human health, bio-medical microsystems (bioMEMS) technologiesincorporate various aspects from materials science,biology, chemistry, physics, medicine, and engi-neering. Reflecting the highly interdisciplinarynature of this area, Biomedical Microsystemscovers the fundamentals of miniaturization, bio-materials, microfabrication, and nanotechnology,along with relevant applications.Written by an active researcher who was recentlynamed one of Technology Review’s YoungInnovators Under 35, the book begins with anintroduction to the benefits of miniaturization. Itthen introduces materials, fabrication technology,and the necessary components of all bioMEMS.The author also covers fundamental principles andbuilding blocks, including microfluidic concepts,lab-on-a-chip systems, and sensing and detectionmethods. The final chapters explore several impor-tant applications of bioMEMS, such as microdialy-sis, catheter-based sensors, MEMS implants, neu-ral probes, and tissue engineering.For students with a limited background in MEMSand bioMEMS, this book provides a practical intro-duction to the technology used to make thesedevices, the principles that govern their operation,and examples of their application. It offers a start-ing point for understanding advanced topics andencourages students to begin to formulate theirown ideas about the design of novel bioMEMS.


• Emphasizes practical knowledge useful forapplication to real-world problems

• Describes research and commercializedbioMEMS devices as well as emerging applications

• Includes detailed examples, laboratory exercises,and a variety of homework problems

• Contains numerous illustrations of concepts,processes, and devices

• Offers downloadable original images for qualifying instructors at www.crcpress.com


Abridged Contents:IntroductionEvolution of MEMSApplications of MEMSBioMEMS ApplicationsMEMS ResourcesText Goals and OrganizationMiniaturization and ScalingBioMEMS MaterialsTraditional MEMS and Microelectronic MaterialsPolymeric Materials for MEMSBiomaterialsMicrofabrication Methods andProcesses for BioMEMSIntroductionMicrolithographyDopingMicromachiningWafer Bonding, Assembly, and PackagingSurface TreatmentConversion Factors for Energy and IntensityUnitsMicrofluidicsIntroduction and Fluid PropertiesConcepts in MicrofluidicsFluid-Transport Phenomena and PumpingFlow ControlLab-on-a-Chip or Micro Total AnalysisSystems

Microanalytical Systems in Chemistry andBiologySample PretreatmentSensing and Detection MethodsApplications to Cells, Nucleic Acids, andProteinsClinical MonitoringMEMS Implants and Bioelectric InterfacesIndex

September 2010, 408 pp. ISBN: 978-1-4200-5122-3, £59.99



18 Request your Complimentary Exam Copy at www.crctextbooks.com

Biomedical Imaging

Coming Soon!

BiomedicalSignal andImageProcessingSecond EditionKayvan NajarianVirginia Commonwealth University, Richmond, USA

Written for senior-level and first year graduatestudents in biomedical signal and image process-ing, Biomedical Signal and Image Processing,Second Edition describes fundamental signaland image processing techniques that are usedto process biomedical information. The book alsodiscusses application of these techniques in theprocessing of some of the main biomedical sig-nals and images, such as EEG, ECG, MRI, and CT.New features of this edition include the technicalupdating of each chapter along with the additionof many more examples, the majority of whichare MATLAB® based.


• Includes updated chapters and all-new examples

• Presents expanded end-of-chapter questions

• Offers enhanced illustration of conceptspresented in the first edition


Contents:

Introduction to Digital Signal and ImageProcessing. Signals and Biomedical SignalProcessing. Fourier Transform. Image Filtering,Enhancement, and Restoration. Edge Detectionand Segmentation of Images. WaveletTransform. Other Signal and Image ProcessingMethods. Clustering and Classification.Processing of Biomedical Signals. ElectricalActivities of Cell. Electrocardiogram.Electroencephalogram. Electromyogram. Other Biomedical Signals. Processing ofBiomedical Images. Principles of ComputedTomography. X-Ray Imaging and ComputedTomography. Magnetic Resonance Imaging.Ultrasound Imaging. Positron EmissionTomography. Other Biomedical ImagingTechniques. Related Titles. Index.

May 2012, 448 pp.ISBN: 978-1-4398-7033-4, £63.99

Applied Medical ImageProcessingA Basic CourseWolfgang BirkfellnerMedical University of Vienna,Austria

“The CD adds substantial value to the text andserves as an excellent guide to practice the infor-mation covered in the text. … Several books onimage processing have been published recently,and this book takes a backseat to none of them.… Students who take a course where this book isused as the course text will be fortunate indeed.”

—William Hendee in Medical Physics

“[A]n outstanding work … [t]he text is easy to follow … . In each well-organized chapter, important concepts and definitions are describedconcisely and well. … The book is enjoyable toread … students will find the entire volume to befilled with important information.”

—Edward J. Ciaccio, Columbia University, BioMedical Engineering OnLine

“I have found this book very useful … . It is com-prehensive and well written.”

—Terry Peters, The University of Western Ontario

“This is a lucid, well-written, and hands-on text-book that explains in simple terms and with exam-ples the basic issues of medical image processing.It contains many examples and useful programs.” —Leo Joskowicz, The Hebrew University of Jerusalem


• Requires little more than basic algebra andbasic programming skills

• Provides a self-contained, complete basicintroduction to the field, emphasizing specialrequirements for processing medical imagingdata

• Covers three-dimensional volume data setscommonly encountered in tomographicimaging

• Addresses the most frequently used visualiza-tion techniques in medical imaging, includingimage segmentation, 3D image fusion, andtomographic reconstruction

• Includes many practical examples for MATLABand Octave with a CD-ROM featuring imagematerial and program files





19

Biophysics


QuantitativeUnderstandingof BiosystemsAn Introduction toBiophysicsThomas M. NordlundUniversity of Alabama atBirmingham, USA

“A beautiful review of essen-tial physics for understand-ing biological systems.”

—Ernest Barreto, George Mason University

“This book is so far the best on the market interms of an undergraduate biophysics textbook.”

—Liviu Movileanu, Syracuse University

“Particularly, it is nice how the book builds uptoward the main equations to make them intu-itive from basic principles.”

—Diego Krapf, School of Biomedical Engineering,Colorado State University

“ [A] nice exposition on the differences betweenhow a biologist approaches a problem and howa physicist does.”

—Charles Wolgemuth, University of ConnecticutHealth Center

“A superb pedagogical textbook about the behaviorand properties of the microscopic structures thatform the essential building blocks of living systems.”

—Midwest Book Review


• Provides a hands-on understanding of themovement of microorganisms, enabling students to analyze positions, velocities, andforces of real microorganisms

• Reviews the necessary mathematics, including geometry, calculus, and differentialequations

• Discusses quantum mechanics in biosystems,covering photosynthesis and micro andchemical reactions

• Describes the transition from discreet randomwalks to continuum diffusive motion

• Contains standard exercises, advanced prob-lems, and miniprojects

• Includes a CD-ROM with "active" versions ofExcel graphs and diagrams from the text,along with links to mathematical and biological/biochemical source data


March 2011, 583 pp.ISBN: 978-1-4200-8972-1, £57.99

New!

Dynamics ofBiologicalSystemsMichael SmallHong Kong PolytechnicUniversity, Kowloon

From the spontaneous rapid firing of cortical neu-rons to the spatial diffusion of disease epidemics,biological systems exhibit rich dynamic behaviorover a vast range of time and space scales.Unifying many of these diverse phenomena,Dynamics of Biological Systems provides thecomputational and mathematical platform fromwhich to understand the underlying processes ofthe phenomena.Through an extensive tour of various biologicalsystems, the text introduces computational meth-ods for simulating spatial diffusion processes inexcitable media, such as the human heart, as wellas mathematical tools for dealing with systems ofnonlinear ordinary and partial differential equa-tions, such as neuronal activation and disease dif-fusion. The mathematical models and computersimulations offer insight into the dynamics of tem-poral and spatial biological systems, including car-diac pacemakers, artificial electrical defibrillation,pandemics, pattern formation, flocking behavior,the interaction of autonomous agents, and hierar-chical and structured network topologies. Toolsfrom complex systems and complex networks arealso presented for dealing with real phenomeno-logical systems.


• Uses complex systems, complex networks,and dynamics to derive models and computersimulations of various biological systems

• Presents a wide range of models, from ECGsignal processing to pandemic modelling topopulation dynamics

• Requires no advanced knowledge of mathematics

• Includes exercises as well as computationaland research projects at the end of eachchapter

• Offers MATLAB implementations of many keyalgorithms and various case studies on theauthor’s website


August 2011, 284 pp. ISBN: 978-1-4398-5336-8, £49.99





Biophysics

New!Physiology,Biophysics andBiomedicalEngineeringEdited by

Andrew W. WoodSwinburne University ofTechnology, Victoria, Australia

Physiology, Biophysics and BiomedicalEngineering provides a multidisciplinary under-standing of biological phenomena and the instru-mentation for monitoring these phenomena. Itcovers the physical phenomena of electricity, pres-sure, and flow along with the adaptation of thephysics of the phenomena to the special condi-tions and constraints of biological systems. Whilethe text focuses on human biological systems,some of the principles also apply to plants, bacte-ria, and other animals.The first section of the book presents a generalintroduction to physiological systems anddescribes specialized methods used to record elec-trical events from biological tissue. The next partexamines molecules involved in cell transport andsignaling as well as the proteins relevant in cells’ability to contract and generate tension. The textgoes on to cover the properties of the heart,blood, and circulation and the monitoring of car-diac and circulatory function. It then discusses theimportance of the interrelationship of pressuresand flows in organ systems, such as the lungs andkidneys, and details the organization and functionof the nervous system. After focusing on the sys-tems used to monitor signals, the book exploresmodeling, biomechanics, and emerging technolo-gies, including the progressive miniaturization ofsensors and actuators in biomedical engineering.


• Offers a multidisciplinary approach to humanbiological systems

• Highlights the application of physics andengineering methods to medicine and biology

• Gives students a solid basis for understandingthe physiological processes in the human body

• Draws on the classroom material of experienced lecturers

• Incorporates a range of numerical problemswith worked solutions


February 2012, 782 pp.ISBN: 978-1-4200-6513-8, £49.99

New!

Physics forDiagnosticRadiologyThird EditionP. P. DendyAddenbrookes NHS Trust,Cambridge, UK

B. HeatonAberdeen Radiation Protection Services, UK

“ … written in a clear and concise style, supportedby excellent illustrations. The textbook describesrecent state-of-the-art advances in medical imag-ing in a way radiologists, radiographers and med-ical physicists will find easy to understand. It isinternationally recognised as one of the key text-books in its field.”

—Dr. Keith Faulkner, North East Strategic Health Authority, UK

Fully revised and updated, Physics forDiagnostic Radiology, Third Edition helps stu-dents understand how various imaging tech-niques work. This edition includes new chapterson PET and PACS as well as new material on dig-ital receptors, radiation doses and risks topatients, and special radiographic techniques,including subtraction techniques and interven-tional radiology. It also emphasizes the differ-ences between analogue and digital images andcovers multi-slice CT and three-dimensional res-olution, dual energy applications, and conebeam CT.


• Explains the underlying physical principles of imaging techniques

• Encourages lateral thinking wherever possible, pointing out the similarities of concepts across different modalities

• Follows the guidelines issued by theEuropean Federation of Organisations inMedical Physics for training in diagnosticradiology

• Contains end-of-chapter exercises as well asseveral multiple choice questions at the backof the book to test comprehension

• Includes extensive cross-referencing, text references, and recommendations for furtherreading

August 2011, 720 pp.ISBN: 978-1-4200-8315-6, £49.99




21For more information and complete contents, visit www.crctextbooks.com

Biotechnology

New!

BiotechnologyFundamentalsFirdos Alam KhanManipal University, Dubai, United Arab Emirates

The focus of Biotechnology Fundamentals is toeducate readers on both classical and modernaspects of biotechnology and to expose them to arange of topics, from basic information to com-plex technicalities. Other books cover subjectsindividually, but this text offers a rare topical com-bination of coverage, using numerous helpful illus-trations to explore the information that studentsand researchers need to intelligently shape theircareers. Keeping pace with the rapid advancement of thefield, topics covered include how biotechnologyproducts are produced, the differences betweenscientific research conducted in universities andthat conducted in industry, which areas ofbiotechnology offer the best and most challeng-ing career opportunities, and key laboratory tech-niques and protocols employed in the field.The contents of this book are derived from discus-sions between teachers and undergraduate stu-dents and designed to address the concepts andmethods thought useful by both sides. Startingwith the fundamentals of biotechnology, coverageincludes definitions, historical perspectives, time-lines, and major discoveries, in addition to prod-ucts, research and development, career prospects,ethical issues, and future trends.


• Includes information on current researchtrends

• Covers novel medical genetics topics such asintra-uterine insemination

• Discusses the process of biotech productdevelopment, with suitable examples

• Examines ethical issues within biotechnologyresearch and product development (e.g.embryonic stem cells, cloning, gene therapy,and GM crops)

• Includes learning objectives for each chapter,in addition to problems, lab assignments, references, and ancillary online resources

• Suggests field trips that can be used to applyand better understand concepts and othermaterial in the book


Abridged Contents:Introduction to BiotechnologyWhat Is Biotechnology?Animal BiotechnologyAgricultural BiotechnologyMedical BiotechnologyIndustrial BiotechnologyEnvironmental BiotechnologyOther Emerging Fields of BiotechnologyHistory of BiotechnologyHuman Genome ProjectMajor Scientific Discoveries in BiotechnologyBiotechnology as the Science of IntegrationBio-RevolutionEthical and Regulatory Issues in BiotechnologyyGenes and GenomicsIntroductionCell as the Building Block of LifeGenes and GeneticsDNA ReplicationDNA Interactions with ProteinsDNA-Modifying EnzymesDNA MethylationDNA MutationProteins and ProteomicsRecombinant DNA TechnologyMicrobial BiotechnologyAgricultural BiotechnologyAnimal BiotechnologyEnvironmental BiotechnologyMedical BiotechnologyNanobiotechnologyProduct Development in BiotechnologyIndustrial BiotechnologyEthics in BiotechnologyCareers in BiotechnologyLaboratory TutorialsGlossary

September 2011, 608 pp.ISBN: 978-1-4398-2009-4, £48.99




Biotechnology

Biotechnology OperationsPrinciples and PracticesMichael J. RoyUniversity of Wisconsin-Madison, USA

Based on the author's extensive teaching experi-ence, Biotechnology Operations: Principlesand Practices introduces key biotechnologydevelopments and covers critical elements ofbiotechnology operations. Comprehensive andpractical, but with a focus on fundamentals, itemphasizes the themes of planning and inte-grating the seven key operational endeavors: sci-entific and management skills of biomanufactur-ing, clinical trials, nonclinical studies, projectmanagement, quality assurance, quality control,and regulatory affairs. The author discussesthese subjects in relation to development plan-ning, process and pathways, management ofintegrated projects, and the business and eco-nomic aspects of development. Describing the functional areas that must besuccessfully integrated to bring a biotechnologyproduct to market, this book presents aroadmap and reference for biotechnology oper-ations, integratingthe functional areas through the processes ofproduct planning and design and the practice ofproject management. It also applies lessonsgleaned during past decades as novel productshave been developed from emerging scientificdiscoveries. The lessons highlight developmentprinciples and practices that could reduce risk,resolve problems, and help the industry to bringsafe and effective biotechnology products of thefuture to market more efficiently and quickly.


• Provides an introduction to each keybiotechnology development subject in one volume

• Incorporates an integrated approach, tyingtogether the various functional areas

• Emphasizes the need to both plan and integrate a program and provides the information with which to successfully leadsuch efforts

• Uses relatively simple language, explains jargon,and uses diagrams to describe processes so subjects are easily understood

Abridged Contents:

Introduction to Biotechnology Operations:Planning for Success

Biotechnology OperationsMarketing, Financial and BusinessConsiderations

for DevelopmentProduct Development PlanningSummary of Planning for SuccessProject ManagementProject Management in BiotechnologyBackground of Project ManagementProject Management in BiotechnologyProject Management in BiotechnologyOperationsProject Management with Contracts andCollaborationsTools for Effective Project ManagementSummary of Project Management inBiotechnology DevelopmentRegulatory AffairsThe U.S. Food and Drug Administration: Lawand Regulations for Biopharmaceuticals

FDA-Regulated ProductsU.S. FDA Regulatory Information and Resources:Regulatory IntelligenceRegulatory Operations for FDA ApplicationsSummary on Regulatory Affairs Activities inBiotechnology OperationsRegulatory ComplianceRegulatory ComplianceQuality Systems to Meet Regulatory ComplianceCompliance for Biopharmaceuticals: OtherRegulations of ImportanceQuality SystemsBiomanufactureQuality ControlNonclinical StudiesClinical TrialsGlossaryAdditional ReadingPractical Problems and Questions

March 2011, 416 pp. ISBN: 978-1-4398-3027-7, £63.99



23

Biotechnology


Healthcare BiotechnologyA Practical GuideDimitris DogramatzisDogramatzis Pharmacy, Athens, Greece

"... particularly strong... provides insight into thebiotechnology business sector."

—British Journal of Biomedical Science

It is a mammoth task to bring a biotechnologyinnovation from inception to widespread thera-peutic use. It takes strong managerial skills and asolid grounding in biopharmaceutical researchand development procedures to foresee and planfor all of the possibilities and pitfalls involved.Healthcare Biotechnology: A Practical Guidefocuses on the management of healthcare-relatedbiotech—from product conception through reg-ulatory approval and the rest of its life cycle.Divided into easily digestible sections, the bookcovers current systems, recent progress and controversy, major players and products, andcomparisons with the pharmaceutical industry. Itcovers topics including:

• Intellectual property protection and management

• The innovation cycle• Patent application• Commercialization and competition• Funding• Partnering• Cash-intensive activities• Financing alternatives• Complexities of alliance implementation andmanagement

Highlighting research, development, and bio-manufacturing, it examines clinical trial designand regulations, "fast-track" approvals, andpatient recruitment, as well as production plat-forms and processes, costs, strategies, and time-lines. The author investigates marketing, includ-ing planning, promotion, pricing, supply chainmanagement, and bio-brand lifecycle manage-ment. He concludes with tips on running thebusiness, offering diverse biobusiness modelsand reasonable expectations, from inceptionthrough maturity and decline.


• Provides problems and essays for each subject covered

• Includes a list of abbreviations and a businessplan outline

• Presents challenging chapter-end questionsand exercises to inspire critical thinking

• Contains hundreds of illustrations, tables, figures, references, and helpful appendices

Solutions manual and more than 1000 PowerPoint®

slides available with qualifying course adoption

Abridged Contents:

The Healthcare Biotechnology IndustryBioeconomyIntellectual PropertyIntellectual Property ManagementBiolicensingFundingBiofinanceBiopartneringNew Product DevelopmentBiodrug ResearchBiomanufacturingMarketingBiomarketing PlanningBiopromotionBiopricingBiosupply ChainBiobrand Life Cycle ManagementRunning the BusinessBiobusiness ModelsBiocompany Life CycleAppendicesDecember 2010, 689 pp.

ISBN: 978-1-4398-4746-6, £66.99




Biotechnology

Environmental Microbiologyfor EngineersVolodymyr IvanovNanyang Technological University, Singapore

Environmental Microbiology for Engineersexamines how microbiology can be used in envi-ronmental research and practical applications.Written for senior undergraduate to graduatelevel civil and environmental engineering stu-dents, this textbook encompasses both funda-mental and applied principles and covers topicssuch as the microbiology of water, wastewater,soil, and air biotreatment systems used in envi-ronmental engineering. It also covers civil engi-neering topics such as biocementation, biocorro-sion, biofouling and biodeterioration of materials.The book provides a thoroughly up-to-dateintroduction to current trends in environmentalmicrobiology and engineering. Microbial classifi-cation is represented as a periodic table withtheoretical connections between all prokaryoticgroups and highlighting their environmentalapplications. Combining microbiological knowl-edge and environmental biotechnology princi-ples in a readable fashion, the text includes top-ics such as:

• Structures and functions of microbial cell and cell aggregates

• Applied microbial genetics and molecularbiology

• Diversity and function of microorganisms in environmental engineering systems

• Environmental bioengineering processes• Microbiological monitoring of environmentalengineering systems

• Microbiology of water and wastewater treatment

• Biocementation and bioc logging of soil• Biocorrosion of constructions• Biodeterioration of materials• Biopollution of indoor environment


• Combines microbiological knowledge andenvironmental biotechnology principles in areadable fashion

• Discusses “hot” topics in the area such asenvironmental bionanotechnology, microbialgeotechnology, and environmental engineer-ing of closed microbial ecosystems

• Teaches with minimal use of mathematicalequations

• Supplies a quiz and tutorial questions at theend of each chapter

• Contains a glossary of terms


Abridged Contents:

Stages of BioprocessingBioagents of BioprocessingMicrobial Metabolism and its controlMolecular Biology and Genetics ofMicroorganismsSelection of Pure CulturesClassifications and Identifications of ProkaryotesPeriodic Table of Physiological Groups ofProkaryotesNutrition and GrowthCultivation of Microorganisms andDownstream ProcessesMicrobial Adaptations and Engineering ControlMicrobial Natural EcosystemsMicrobial Engineering EcosystemsPublic Health Microbiology for EngineersMicrobiology of Water TreatmentMicrobiology of Aquatic EcosystemsMicrobiology of Anaerobic WastewaterTreatmentMicrobiology of Aerobic Wastewater TreatmentMicrobiology of Solid Wastes BiotreatmentMicrobiology of Soil BioremediationMicrobiology of Exhaust Gases BiotreatmentBiocorrosion, Biodeterioration and Biofouling

November 2010, 438 pp.ISBN: 978-1-4200-9234-9, £66.99



25

Biotechnology


Fundamentalsof Microfluidicsand Lab on aChip forBiologicalAnalysis andDiscoveryPaul C.H. LiSimon Fraser University, Burnaby,British Columbia, Canada

Lab-on-a-chip technology now permits us tomake many important discoveries that can onlybe observed at the microscale or the nanoscale.The newest advances employed in biologicaland biochemical analysis translates into greatersensitivity, more accurate results, and more valu-able findings. Authored by one of the field’s pio-neering researchers, Fundamentals ofMicrofluidics and Lab on a Chip for BiologicalAnalysis and Discovery focuses on all keyaspects of the microfluidic lab-on-a-chip tech-nologies to offer an exceptionally cohesiveoverview of the science, its limitations, break-throughs made over the years, and currentlyemerging advances.The book emphasizes analytical applications ofmicrofluidic technology and offers in-depth cov-erage of micromachining methods, microfluidicoperations, chemical separations, sample prepa-ration and injection methods, detection technol-ogy, and various chemical and biological analy-ses. Other topics of interest include the use ofpolymeric chips, fluid flow valve and control,single-cell analysis, DNA and RNA amplificationtechniques, DNA hybridization, immunoassays,and enzymatic assays.


• Reviews fundamentals of micromachiningand fluid flow and control for lab-on-a-chip

• Emphasizes analytical applications ofmicrofluidic technology

• Contains tables that summarize related materials

• Provides problem sets that test students’comprehension of the material

• Includes a glossary, extensive references, and a four-page color insert


February 2010, 418 pp.Soft Cover, ISBN: 978-1-4398-1855-8, £38.99

Systems Biology andBioinformaticsA ComputationalApproachKayvan Najarian,Christopher N.Eichelberger, Siamak Najarian, andShahriar Gharibzadeh

Emphasizing computational methods, SystemsBiology and Bioinformatics: A ComputationalApproach provides an introduction to systembiology and its impact on biology and medicine.It reviews basic principles of molecular and cellbiology using a system-oriented approach, witha brief description of the high-throughput bio-logical experiments that produce databases. Themethods presented include techniques to dis-cover genes, perform nucleotide and amino acidsequence matching, and estimate static genedynamic pathways. It also explains applicationsfor system-oriented models to predict thebehavior of biological systems.April 2009, 190 pp.ISBN: 978-1-4200-4650-2, £47.99

Colloids andInterfaces inLife Sciencesand Bionano-technologySecond EditionWillem NordeWageningen University,The Netherlands, and UniversityMedical Center Groningen, The Netherlands

Colloids and Interfaces in Life Sciences andBionanotechnology is a classroom-tested refer-ence that presents a concise introductory treat-ment of the physicochemical principles thatdetermine interrelated colloidal and interfacialphenomena and their relevance to various lifesciences. The book examines the spontaneousassembly of amphiphilic molecules and theintentional fouling of surfaces for the immobi-lization of cells in bioreactors. It also devotesspecial attention to reversible and soft colloids,discusses the colloidal domain in a historical per-spective, and reviews the size and distribution ofparticles, electrokinetic phenomena.June 2011, 495 pp.ISBN: 978-1-4398-1718-6, £39.99





General Textbooks


A First Coursein DifferentialEquations,Modeling, andSimulationCarlos A. Smith andScott W. CampbellUniversity of South Florida,Tampa, USA

Emphasizing a practical approach, A First Coursein Differential Equations, Modeling, andSimulation avoids overly theoretical explanationsand shows students how differential equationsarise from applying basic physical principles andexperimental observations to engineering sys-tems. It also covers classical methods for obtainingthe analytical solution of differential equations andLaplace transforms. The authors discuss how theseequations describe mathematical systems andhow to use software to solve sets of equationswhere analytical solutions cannot be obtained. Using simple physics, the book introduces dynam-ic modeling, the definition of differential equa-tions, two simple methods for obtaining their ana-lytical solution, and a method to follow whenmodeling. It then presents classical methods forsolving differential equations, discusses the engi-neering importance of the roots of a characteristicequation, and describes the response of first- andsecond-order differential equations. A study of theLaplace transform method follows with explana-tions of the transfer function and the power ofLaplace transform for obtaining the analytical solu-tion of coupled differential equations.


• Teaches how to model engineering systems

• Reviews the necessary physics material

• Explores how to obtain the analytical solutionof differential equations using actual physicalsystems

• Discusses how the roots of the characteristicequation provide the qualitative nature of the response of any system

• Explains how to use simulation software

• Provides numerical values in all examplesand problems


May 2011, 345 pp.ISBN: 978-1-4398-5087-9, £57.99

TechnicalWritingA Practical Guide for Engineers and ScientistsPhillip A. LaplanteThe Pennsylvania StateUniversity, Malvern, USA

Written by a renowned engineer and widely pub-lished technical author, Technical Writing APractical Guide for Engineers and Scientiststeaches students how to write, edit, and publishmaterials of a technical nature, including books,articles, reports, and electronic media. Drawingon his own work, the author presents many first-hand examples of writing, editing, and publishing technical materials. These examplesillustrate how a publication originated, challengeswriters encounter, and various solutions.

July 2011, 250 pp.Soft Cover, ISBN: 978-1-4398-2085-8, £25.99

RandomPhenomenaFundamentals ofProbability andStatistics forEngineersBabatunde A.OgunnaikeUniversity of Delaware, Newark, USA

Many of the problems that engineers faceinvolve randomly varying phenomena. But evensuch randomness and the resulting uncertaintyare subject to rigorous mathematical analysis.Random Phenomena: Fundamentals ofProbability and Statistics for Engineers pro-vides students with a fundamental understand-ing of random phenomena and a workingknowledge of how to model and analyze suchphenomena. Explaining how to use probabilityand statistics to confront uncertainty in engi-neering problems, Dr. Ogunnaike bases hisapproach on the principle of theoretical founda-tions before application.






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Bioengineering & Biotechnology

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