Amino Acids as Protein Building Blocks
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Transcript of Amino Acids as Protein Building Blocks
Amino Acids as Protein Building Blocks
Proteins are naturally-occurring biopolymers comprised of amino acids.
The biological function of proteins is inherent in their three dimensional structure.
All the information required for correct folding of the protein into its functional native structure is contained in the primary sequence of amino acids.
The physical chemical properties of the amino acids contain the biological information required for folding and function.
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Structure of Ubiquitin
By convention the primary sequence of amino acids is listed left to right from the amino terminus to the carboxyl terminus.
Fundamental Structure of Amino Acids
Amino acids are most logically grouped according to the physical properties of their side chains.
Aliphatic Amino Acids
Aromatic Amino Acids
Polar Amino Acids
Disulfide Bond Formation
Acidic Amino Acids
Mechanism of Asn/Gln Deamidation
Basic Amino Acids
R74D39
R72K27E51D52E24R54
D58
E18K63
E64
K48
K6
R42
Representations of Protein Surfaces