CEA CHRU CNRS CPU INRA INRIA INSERM INSTITUT PASTEUR IRD

1CEA CHRU

CNRS CPU INRA

INRIA INSERM

INSTITUT PASTEUR

IRD

 3rd International Research MeetingJune 10th, 2011, Hôtel Marigny

Introduction

Pr Jean-François Delfraissy

Institut de Microbiologie et Maladies Infectieuses (IMMI)

Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)

CHU Bicetre – Paris XI

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2

% of deaths18%

15%

31%

36%PneumoniaDiarrhoeaOther infectionsNon infectious

Infectious diseases account for 26% of all deaths worldwide

Leading cause of mortality in ressources limited countries

Two-thirds of worldwide deaths

in children <5 years old

The Heavy Burden of Infectious Diseases

CEA CHRU CNRS CPU INRA INRIA INSERM INSTITUT PASTEUR IRD

« Emergence »: a global threat

Vectors

Hosts

Humans

• Newly apparent pathogens: HIV, Ebola, H5N1, H1N1…

• Rapidly increasing in incidence or geographic range : dengue,

chikungunya, West Nile

• Multidrug Resistant Pathogens :

NDM-1, E.Coli (EHEC)

• Importance of zoonosis

→Multidisciplinary approach

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A new vision of microbiology

• Discovery of new viruses, new bacteria

• The commensal microbiota : from homeostasis to disease

• New technologies : deep sequencing, omics…

• Molecular basis of host defense

• Host genetic control

• Biomarkers, Point of care, Pharmacogenomics

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Medical and Scientific challenges

• Transmission of infection (mechanisms, nosocomial…)

• Emerging diseases; zoonosis, human ecology, biodiversity

• Resistance : Tuberculosis, Bacteria, MDR…

• Infectious agents and non infectious diseases: cancer,

cardiovascular, obesity, allergy, inflammation,…

• Vaccination: new vaccines, immunity, SHS…

• The big 3 : HIV, Tuberculosis, Malaria

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IMMI: French Biomedical research Centers

Institut Pasteur ParisPitié SalpétrièreMondor/Bicêtre/Orsay/CEA/SaclayBichat/St LouisCochin/Cordeliers

BIOPOLE Lyon-Grenoble IRT Lyon/Pasteur

Institut Pasteur Lille

Bordeaux

Strasbourg

INFECTIOPOLE SudMarseille-Montpellier-NiceIHU

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Microbiology and Infectious DiseasesKey points: France 2011

• Major Institutions : Institut Pasteur, Inserm, CNRS, IRD

• Others : ANRS, CEA, CIRAD, INRA, INVS, Universities

• 12% of French research forces: 300 teams, 2000 Scientists & Technical staff

• 18% of French biomedical publications: 5000 publications per year

• Translationnal and clinical research: 35 clinical units involved, including HIV and hepatits

• Network of vaccine research centers

• Large research network in ressources limited countries

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Scientific Program (1)

8.55 -11.30

• Session 1: UNDERSTANDING INFECTIOUS DISEASES: NEW

MECHANISMS & PARADIGMS

• Session 2: NEW TARGETS AND TOOLS IN INFECTIOLOGY

11.30 Transfer to Elysée Palace

12.15 The President Sarkozy Lecture

12.45 – 13.45 Buffet-Lunch

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Scientific Program (2)

14.00 – 14.30 • Session 3: NORTH-SOUTH PARTNERSHIPS:

POWERFUL RESEARCH TOOLS

14.30 – 17.00 R&D Dating Session :

Twenty one companies will meet successively with 4 scientific teams representatives

This very short meeting allows to define whether a future in depth meeting should be scheduled in case of confirmed common interests

17.15 Conclusion remarks: Pierre TEILLAC – Chairman of ARIIS

17.45 Allocution by the Minister Mr Eric BESSON