1 Macromolecules copyright cmassengale. 2 Organic Compounds CompoundsCARBON organicCompounds that...

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MacromolecMacromoleculesules

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Organic Organic CompoundsCompounds

• CompoundsCompounds that contain CARBONCARBON are called organicorganic.

• MacromoleculesMacromolecules are large organic moleculesorganic molecules.


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Carbon (C)Carbon (C)• CarbonCarbon has 4 electrons4 electrons in

outer shell.

• CarbonCarbon can form covalent covalent bondsbonds with as many as 4 4 other atoms (elements).

• Usually with C, H, O or NC, H, O or N.

• Example:Example: CHCH44(methane)(methane)


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MacromoleculesMacromolecules

• Large organic molecules.Large organic molecules.• Also called POLYMERSPOLYMERS.• Made up of smaller “building

blocks” called MONOMERSMONOMERS.• Examples:Examples:

1. Carbohydrates1. Carbohydrates2. Lipids2. Lipids3. Proteins3. Proteins4. Nucleic acids (DNA and RNA)4. Nucleic acids (DNA and RNA)


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Question:Question:How Are How Are

MacromolecMacromolecules ules

Formed?Formed?copyright cmassengale

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Answer:Answer: Dehydration Dehydration SynthesisSynthesis

• Also called “condensation “condensation reaction”reaction”

• Forms polymerspolymers by combining monomersmonomers by “removing “removing water”water”.

HO H

HO HO HH

H2O


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Question:Question: How are How are

Macromolecules Macromolecules separated or separated or

digested?digested?


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Answer: Answer: HydrolysisHydrolysis

•Separates monomersmonomers by “adding water”“adding water”

HO HO HH

HO H

H2O


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CarbohydratCarbohydrateses


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CarbohydratesCarbohydrates

• Small sugar moleculesSmall sugar molecules to large sugar moleculeslarge sugar molecules.

• Examples:Examples:A.A. monosaccharidemonosaccharideB.B. disaccharidedisaccharideC.C. polysaccharidepolysaccharide


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CarbohydratesCarbohydratesMonosaccharide: one sugar Monosaccharide: one sugar

unitunit

Examples:Examples: glucose (glucose (C6H12O6)

deoxyribosedeoxyribose

riboseribose

FructoseFructose

GalactoseGalactose

glucoseglucose


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CarbohydratesCarbohydratesDisaccharide: two sugar unitDisaccharide: two sugar unit

Examples: Examples: – Sucrose (glucose+fructose)Sucrose (glucose+fructose)– Lactose (glucose+galactose)Lactose (glucose+galactose)– Maltose (glucose+glucose)Maltose (glucose+glucose)

glucoseglucoseglucoseglucose


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CarbohydratesCarbohydratesPolysaccharide: many sugar unitsPolysaccharide: many sugar units

Examples:Examples: starch (bread, starch (bread, potatoes)potatoes)

glycogen (beef glycogen (beef muscle)muscle)

cellulose (lettuce, cellulose (lettuce, corn)corn)





cellulosecellulose


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LipidsLipids


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LipidsLipids• General term for compounds which are not not

soluble in watersoluble in water.• Lipids are soluble in hydrophobic solventsare soluble in hydrophobic solvents.• Remember:Remember: “stores the most energy”“stores the most energy”• Examples:Examples: 1. Fats1. Fats

2. Phospholipids2. Phospholipids3. Oils3. Oils4. Waxes4. Waxes5. Steroid hormones5. Steroid hormones6. Triglycerides6. Triglycerides


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LipidsLipidsSix functions of lipids:Six functions of lipids:

1.1. Long term Long term energy storageenergy storage2.2. Protection against heat loss Protection against heat loss (insulation)(insulation)3.3. Protection against physical shockProtection against physical shock4.4. Protection against water lossProtection against water loss5.5. Chemical messengers (hormones)Chemical messengers (hormones)6.6. Major component of membranes Major component of membranes (phospholipids)(phospholipids)


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LipidsLipidsTriglycerides:Triglycerides:

ccomposed of 1 glycerol1 glycerol and 3 3 fatty acidsfatty acids.

H

H-C----O

H-C----O

H-C----O

H

glycerol

O

C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3

=

fatty acids

O


=

O

C-CH2-CH2-CH2-CH =CH-CH2 -CH

2 -CH2 -CH

2 -CH3

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Fatty AcidsFatty AcidsThere are two kinds of fatty acidsfatty acids you may see these on

food labels:

1.1. Saturated fatty acids:Saturated fatty acids: no double bonds (bad) no double bonds (bad)

2.2. Unsaturated fatty acids:Unsaturated fatty acids: double bonds (good) double bonds (good)O


=

saturatedsaturated

O

C-CH2-CH2-CH2-CH=CH-CH2 -CH

2 -CH2 -CH

2 -CH3

=

unsaturated


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ProteinsProteins


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Proteins Proteins (Polypeptides)(Polypeptides)

• Amino acids (20 different kinds of aa) bonded together by peptide bondspeptide bonds (polypeptidespolypeptides).

• Six functions of proteins:Six functions of proteins:1.1. Storage:Storage: albumin (egg white)albumin (egg white)2.2. Transport: Transport: hemoglobinhemoglobin3.3. Regulatory:Regulatory: hormoneshormones4.4. Movement:Movement: musclesmuscles5.5. Structural:Structural: membranes, hair, nailsmembranes, hair, nails6.6. Enzymes:Enzymes: cellular reactionscellular reactions


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Proteins Proteins (Polypeptides)(Polypeptides)

Four levels of protein Four levels of protein structure:structure:

A.A. Primary StructurePrimary Structure

B.B. Secondary Structure Secondary Structure

C.C. Tertiary Structure Tertiary Structure

D.D. Quaternary Structure Quaternary Structure


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Primary StructureAmino acids bonded

together by peptide peptide bonds (straight chains)bonds (straight chains)

aa1 aa2 aa3 aa4 aa5 aa6

Peptide Bonds

Amino Acids (aa)


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Secondary StructureSecondary Structure

• 3-dimensional folding arrangement of a primary primary structurestructure into coilscoils and pleatspleats held together by hydrogen bondshydrogen bonds.

• Two examples:Two examples:

Alpha HelixAlpha Helix

Beta Pleated SheetBeta Pleated Sheet

Hydrogen BondsHydrogen Bondscopyright cmassengale

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Tertiary StructureTertiary Structure• Secondary structuresSecondary structures bentbent and

foldedfolded into a more complex 3-D more complex 3-D arrangementarrangement of linked polypeptides

• Bonds: H-bonds, ionic, disulfide Bonds: H-bonds, ionic, disulfide bridges (S-S)bridges (S-S)

• Call a “subunit”.“subunit”.

Alpha HelixAlpha Helix

Beta Pleated SheetBeta Pleated Sheetcopyright cmassengale

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Quaternary Quaternary StructureStructure

•Composed of 2 or more “subunits”•Globular in shape•Form in Aqueous environments•Example: enzymes (hemoglobin)enzymes (hemoglobin)

subunitssubunits


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Nucleic Nucleic AcidsAcids


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Nucleic acidsNucleic acids• Two types:Two types:

a. Deoxyribonucleic acid a. Deoxyribonucleic acid (DNA-(DNA- double helix) double helix) b. Ribonucleic acid (RNA-single b. Ribonucleic acid (RNA-single strand) strand)

• Nucleic acids Nucleic acids are composed of long chains of nucleotidesnucleotides linked by dehydration synthesisdehydration synthesis.


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Nucleic acidsNucleic acids• Nucleotides include:Nucleotides include:

phosphate groupphosphate grouppentose sugar (5-carbon)pentose sugar (5-carbon)nitrogenous bases:nitrogenous bases:

adenine (A)adenine (A)thymine (T) DNA onlythymine (T) DNA onlyuracil (U) RNA onlyuracil (U) RNA onlycytosine (C)cytosine (C)guanine (G)guanine (G)


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NucleotideNucleotide

OO=P-O O

PhosphatePhosphate GroupGroup

NNitrogenous baseNitrogenous base (A, G, C, or T)(A, G, C, or T)

CH2

O

C1C4

C3 C2

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SugarSugar(deoxyribose)(deoxyribose)


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DNA - double helixDNA - double helix

P

P

P

O

O

O

1

23

4

5

5

3

3

5

P

P

PO

O

O

1

2 3

4

5

5

3

5

3

G C

T A


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