104/21/23

UL evaluation 2012

Life Sciences

Luxembourg Centre for Systems Biomedicine(LCSB)

rudi.balling@uni.lu

17th February 2012

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LCSB: An Interdisciplinary Centre LCSB: An Interdisciplinary Centre within the Universitywithin the University

LanguageLiterature

HumanititesArts

Education

(FLSHASE)

Systems Biomedicine(LCSB)

ScienceTechnology

Communication

(FSTC)

LawEconomics

Finance

(FDET)

Security, Reliability, Trust (SNT)

FacultiesFaculties

Interdisciplinary Interdisciplinary CentresCentres

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LCSB: The First 2 Years

September 2009 September 2011

Clinical Research

Computational Biology

Technical Platforms

Experimental Biology

LCSB

Luxembourg Centre for Systems Biomedicine (LCSB)

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The interdisciplinary nature of the LCSB

Bioinformatics

Parkinson`s Disease

Experimental Biomedicine

Gene-Environment Interactions

Modelling and Simulation

Computational Biology

PublicHealth

Transcriptomics Proteomics

Metabolomics

Animal ModelsHuman Genetics

Chemical BiologyImaging

Theory

Experiments

Technology

6

MiceMiceCellsCells PatientsPatients

Network models of diseases: Inference and analysisNetwork models of diseases: Inference and analysis

Thematic focus

FamiliesFamiliesComputerComputer

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Thematic focus

8

Thematic focus

The LCSB Parkinson's DiseaseResearch Program

The LCSB Parkinson's DiseaseResearch Program

Clinical PD projectsClinical PD projects

Computational Models of PD

Computational Models of PD

Sequencing of PD patientsSequencing of PD patients

Mitochondrial dysfunctionin PD patients

Mitochondrial dysfunctionin PD patients

Metabolome analysis of PD-patients

Metabolome analysis of PD-patients

DJ-1, PINK-1-Synucleinmouse models of PD

DJ-1, PINK-1-Synucleinmouse models of PD

Comparative Human-Mouse Systems Analysis

Comparative Human-Mouse Systems Analysis

A PD-SBGN-mapA PD-SBGN-map

PD-network analysis inSH-SY5Y cells

PD-network analysis inSH-SY5Y cells

Neuron-Astrocyte-Microglia Crosstalk

Neuron-Astrocyte-Microglia Crosstalk

Nico DiederichPaul Antony

Manuel Buttini

Antonio del SolAvrind Tallam

Paul AntonyPatrick May

Karsten Hiller

Alessandro Michelucci

Animal and Cellular Models of PD

Animal and Cellular Models of PD

iPS-cells from PD-patients

iPS-cells from PD-patients

Lasse Sinkkonen

SBI & LCSB

David Galas/ISB

A kinetic model of PD related ROS generation

A kinetic model of PD related ROS generation

Alexey Kolodkin

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Organisational structure: Research groups

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Experimental Biology(Sept 2009)

Metabolomics(Sept 20010)

Eco-Systems Biology

(October 2011)

Endocrinology(February 2011)

Computational Biology(February 2010)

Bioinformatics(April 2011)

Machine Learning(November 2010)

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Bioinformatics and Computational Biology

Reinhard Schneider Antonio del Sol Nikos Vlassis

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Nico Diederich

Organisational Structure: Translational Research

10 % LCSB

90 % Clinic (CHL)

Carine de Beaufort

25 % LCSB

75 % Clinic (CHL)

Jochen Schneider

80 % LCSB

20 % Clinic

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Experimental Models of Parkinson´s disease

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Eco-Systemsbiology in the Gut

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Technology Focus: Metabolomics

LPS

The Karsten Hiller-TeamAlessandro Michelucci

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LCSB: The Integration within the UL

CSCCSCLSRULSRU

Doctoral School

Doctoral School

•Professorships•Projects•Personnel•Teaching•Infrastructure

• LCSB and LSRU PhD students

• Projects• Students• IT infrastructure

LCSBLCSB

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LCSB: The National Collaborations

The Personalised Medicine Consortium

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Personalized Medicine Consortium (PMC)

Diabetes Disease

Team

Diabetes Disease

Team

Parkinson Disease

Team

Parkinson Disease

Team

Cancer Disease

Team

Cancer Disease

Team

Nico DiederichRudi Balling

Nico DiederichRudi Balling

Team Leaders Carine de Beaufort

Jochen SchneiderCarine de Beaufort Jochen Schneider

Guy BerchemBruno DomonGuy BerchemBruno Domon

Project Manager Marek OstaszewskiMarek Ostaszewski tbdtbd tbdtbd

In each team: 2-3 clinicians and 2-3 basic scientistsIn each team: 2-3 clinicians and 2-3 basic scientists

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LCSB: The International Collaborations

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LCSB: The challenges