WORKING FOR A HEALTHY FUTURE

INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org

Example calculations using ART

Powder exposure in pharmaceutical industry

John Cherrie and Martie van Tongeren for the ART consortium

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Data collection – BOHS survey

• BOHS funded project• Using BOHS Registered Consultants to collect

data and contextual information• We developed:• Spreadsheet for collecting contextual information• Guidelines for data quality

• Data were checked by IOM

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Results for BOHS – ART data collection

• Three consultants contributed data• 18 exposure scenarios

• Pharmaceutical industry (5 scenarios)• Rubber (4 scenarios)• Metal industry (3 scenarios)• Woodworking (1 scenarios)• Dental laboratory (1 scenario)• Construction (1 scenario) • Manufacture of labels (1 scenario)• Histology laboratory (1 scenario)• Paint manufacture (1 scenario)

• Total 143 Measurements with contextual data

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Case 1: Scenario description…

• Manufacturing of pharmaceutical products. • Handling pharmaceutical active ingredients in

powder form (discharge of mixer into kegs or IBC, and check-weighing)

• Activities include Mixing, Blending, Filling kegs and IBCs, Tablet compression, and Film coating. Some process steps were automated and carried out inside closed equipment, with others requiring manual intervention.

• LEV and other engineering controls, plus PPE were used depending on the activity

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Operator checks powder flow

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Filling kegs from blender…

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Check weighing…

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Application of ART

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Scenario overview…

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Scenario overview: activities…

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Exposure Data…

Site ID Worker IDConc

mg/m3A A 0.21A B 2.1A C 0.99A D 0.32B E 0.74B F 1.3B G 2.7B H 1B I 5.8

Data set 1 (only site A) and 2 (Site A and B) Data set 3

Site ID Worker IDConc

mg/m3A A 0.021A B 2.1A C 0.99A D 0.032B E 0.74B F 1.3B G 20.7B H 1B I 50.8

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Summary…

• ART is relatively straightforward to use• Follows a logical scheme• Allows for the easy input of data to update the

mechanistic model prodictions