The Advanced REACH Tool (ART) - an example
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WORKING FOR A HEALTHY FUTURE INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom- world.org Example calculations using ART Powder exposure in pharmaceutical industry John Cherrie and Martie van Tongeren for the ART consortium
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This is a presentation made at the BOHS REACH meeting in Brussels in 2009.
Transcript of The Advanced REACH Tool (ART) - an example
WORKING FOR A HEALTHY FUTURE
INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org
Example calculations using ART
Powder exposure in pharmaceutical industry
John Cherrie and Martie van Tongeren for the ART consortium
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Data collection – BOHS survey
• BOHS funded project• Using BOHS Registered Consultants to collect
data and contextual information• We developed:• Spreadsheet for collecting contextual information• Guidelines for data quality
• Data were checked by IOM
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Results for BOHS – ART data collection
• Three consultants contributed data• 18 exposure scenarios
• Pharmaceutical industry (5 scenarios)• Rubber (4 scenarios)• Metal industry (3 scenarios)• Woodworking (1 scenarios)• Dental laboratory (1 scenario)• Construction (1 scenario) • Manufacture of labels (1 scenario)• Histology laboratory (1 scenario)• Paint manufacture (1 scenario)
• Total 143 Measurements with contextual data
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Case 1: Scenario description…
• Manufacturing of pharmaceutical products. • Handling pharmaceutical active ingredients in
powder form (discharge of mixer into kegs or IBC, and check-weighing)
• Activities include Mixing, Blending, Filling kegs and IBCs, Tablet compression, and Film coating. Some process steps were automated and carried out inside closed equipment, with others requiring manual intervention.
• LEV and other engineering controls, plus PPE were used depending on the activity
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Operator checks powder flow
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Filling kegs from blender…
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Check weighing…
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Application of ART
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Scenario overview…
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Scenario overview: activities…
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Exposure Data…
Site ID Worker IDConc
mg/m3A A 0.21A B 2.1A C 0.99A D 0.32B E 0.74B F 1.3B G 2.7B H 1B I 5.8
Data set 1 (only site A) and 2 (Site A and B) Data set 3
Site ID Worker IDConc
mg/m3A A 0.021A B 2.1A C 0.99A D 0.032B E 0.74B F 1.3B G 20.7B H 1B I 50.8
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Summary…
• ART is relatively straightforward to use• Follows a logical scheme• Allows for the easy input of data to update the
mechanistic model prodictions
