Steroidal Hormones

Post on 23-Jan-2016

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Transcript of Steroidal Hormones

STEROIDS

A steroid hormone (abbreviated as sterone) is a steroid that acts as ahormone. Steroid hormones can be grouped into five groups by the receptors to which they bind: glucocorticoids, mineralocorticoids, androgens, estrogens, and progestogens..

Mineralocorticoids

class of steroid hormones characterized by their influence on salt and water balances. The primary mineralocorticoid is aldosterone

doxycorticosterone fludrocortisone

Mineralocorticoids

Mode Of Action The effects of mineralocorticoids are

mediated by slow genomic mechanisms through nuclear receptors as well as by fast nongenomic mechanisms through membrane-associated receptors and signaling cascades.

Glucocorticoids

Glucocorticoids (GCs) are a class of steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell.

The name glucocorticoid (glucose + cortex + steroid) derives from its role in the regulation of the metabolism of glucose, its synthesis in the adrenal cortex, and its steroidal structure

Glucocorticoids

Agents of glucocorticoids: Cortisol Prednisone Cortisone Prednisolone Dexamethasone Methylprednisolone

SAR(structure activity relationship)

Brands available

PROGESTRONE: ALGEST CYGEST CONEST CRINONE E- GEST

Brands available TESTOSTERONE:

( TESTOSTERONE ENANTHATE- GENERIC) . CORTISOL: Aclovate Acticort Aeroseb-Dex CaldeCORT Hydro-Tex Lanacort