Post on 19-May-2015
Electrophysiological tests for the CNS
� Concept� Positioning
• High Quality Service• Central Nervous System• Functional Electrophysiology
Summary
• Functional Electrophysiology• High Skill Expertise
� Studies• Models• Portfolio• Scope
� Commitments� Benefits� Goal
NEUROSERVICE provides advanced tests and expertise in Functional Electrophysiology for the CNS :
� In vitro physiologyAcute Brain Slices recording : MEA, Patch-Clamp
Concept
� Acute Brain Slices recording : MEA, Patch-Clamp
� Standardized & Customised tests
[NBQX] in µM0.001 0.01 0.1 1 10 100
Nor
mal
ized
fEP
SP
0.0
0.2
0.4
0.6
0.8
1.0
1.2
n = 5 electrodes (one slice)
Positioning
FunctionalElectrophysiology
High QualityService
Central Nervous System
High SkillExpertise
High Quality Service
FlexibilityFlexibility
Expert supportExpert support
Short time Short time
processprocess
Reliability Reliability
of testsof tests
Quality InsuranceQuality Insurance
& Confidentiality& Confidentiality
The best quality ofService to satisfy
your needs
Central Nervous System
Acute Acute brainbrain
slicesslices
CNS disorders CNS disorders
Single neuron Single neuron TargetsTargets
A wide rangeof recordings
to fit your needs
Functional Electrophysiology
StandardizedStandardized
protocolsprotocols
CustomizedCustomized
protocolsprotocols
Mid troughoutputMid troughoutput MEA&PatchMEA&Patch
recording recording
The bestElectrophysiologyto empower yourscientific analysis
High Skill Expertise
ElectrophysiologyElectrophysiology Drug DiscoveryDrug Discovery
NeuroNeuro
PharmacologyPharmacology
NeuroNeuro
PhysiologyPhysiology
A High Expertise to fulfill your needs
� Molecules effects on neurons and neuronal networks� Targets & mechanisms of action� Interaction of a new molecule with an existing drug� Compound profiling
Studies
� Transgenic mice phenotyping� Consulting
[NBQX] in µM0.001 0.01 0.1 1 10 100
Nor
mal
ized
fEP
SP
0.0
0.2
0.4
0.6
0.8
1.0
1.2
n = 5 electrodes (one slice)
Models
� Hippocampal slices (glutamat- & GABAergic neurons in DG, CA3, CA1)� Cerebellar slices (Purkinje GABAergic large neurons)� Substantia Nigra (Dopaminergic neurons of pars compacta)compacta)� Cortex slices (glutamat- & GABAergic neurons in 5-6 layers)� Raphe nucleus (Serotoninergic neurons)� Thalamus & cortex� Striatum & brainstem� Spinal Cord
Portfolio Tests 1/3
Test # Reference compound Target Associated pathologiesP-001 Tetrodotoxin Sodium channel Epilepsy
Pain and Neuropathic PainHuntington’s DiseaseMultiple Sclerosis
P-002 NBQX AMPA/KA receptors StrokeEpilepsyAmyotrophic Lateral Sclerosis
P-003 D-AP5 NMDA receptor Alzheimer’s DiseaseP-003 D-AP5 NMDA receptor Alzheimer’s DiseaseParkinson’s DiseaseHuntington’s DiseaseSchizophrenia
P-004 Bicuculline GABA-A receptors EpilepsyAnxietySleep Disorders
P-005 Ganaxolone GABA-A receptors EpilepsyAnxietySleep disorders
P-006 Gabazin GABA-A receptors EpilepsyAnxietySleep Disorders
Portfolio Tests 2/3
P-007 DHPG mGluR 1/5 receptors StrokeEpilepsyNeurodegenerationAddictionAnxietyPain Management
P-008 Kainate AMPA/kainate receptors StrokeEpilepsyPainPainCognitive Dysfunctions
P-009 Nifedipine L-Type VDCC StrokeCognitive DysfunctionsEpilepsyDepression
P-010 Physostigmine Acetylcholinesterase Alzheimer’s DiseaseDementiaCognitive DysfunctionAttention Deficits Disorders
P-011 Memantine NMDA receptor Alzheimer’s Diseasenicotinic receptors Parkinson’s Disease
Dementia
Portfolio Tests 3/3
P-012 R-α-methylhistamine H3 histamine receptor Cognitive DisordersAlzheimer’s DiseaseParkinson’s DiseaseHyperactivity and Attention Deficit DisordersSleep DisordersObesityEpilepsy
P-013 Pyrilamine H1 histamine receptorsRanitidine H2 histamine receptorsRanitidine H2 histamine receptors
P-014 DCG-IV mGluR2 receptor Obsessive-Compulsive DisordersAnxiety/Stress DisordersDrug/Alcool Addiction
P-015 SCH23390 D1 dopamine receptor Cognitive DysfunctionD5 dopamine receptor Parkinson's Disease
P-016 Phenytoin K+ channels EpilepsyCarbamazepine
P-017 Carbamazepine NMDA receptor EpilepsyPhenytoin
P-018 Somatostatin GABA-A receptor Epilepsy
P-019 Diazepam GABA-A receptor Epilepsy
Scope
Addiction P-007, P-014Alzheimer’s Disease P-003, P-010, P-011, P-012Amyotrophic Lateral Sclerosis P-002Anxiety P-004, P-005, P-006, P-007, P-014Cognitive Disorders P-008, P-009, P-010, P-012, P-015Dementia P-010, P-011Depression P-009Depression P-009Epilepsy P-001, P-002, P-004, P-005, P-006, P-007,
P-008, P-009, P-012, P-016, P-017, P-018, P-019Huntington’s Disease P-003Hyperactivity and Attention Deficit Disorders P-010, P-012Multiple Sclerosis P-001Neurodegeneration P-007Neuropathic Pain P-001Obsessive-Compulsive Disorders P-014Pain P-001, P-007, P-008Parkinson’s Disease P-003, P-011, P-012, P-015Schizophrenia P-003Sleep Disorders P-004, P-005, P-006, P-012Stroke P-002, P-007, P-008, P-009
� Robust and reproduceable data
� High Quality service
� Short time processes
Commitments
� Short time processes
� Mid-throughoutput
� Expert support
� Confidentiality
Benefits
� Cost & Time saving
� Risk reducing
� Efficiency in scientific analysis
� Tests capacity
� Flexibility
Our Goal
To provide you with the best quality services in quality services in
Electrophysiological tests for the CNS to empower your
Science.