Post on 13-Aug-2020
Leaky Heart Syndrome
Jack Wolfson DO, FACCTheDrsWolfson.com
▪ D.O. 1996- Midwestern Univ.
▪ Internal Medicine 96-99
▪ Cardiology 1999-2002
▪ Chief fellow
▪ Senior partner of a large cardiology
group, 2002-2012
▪ Chairman of Dept. of Medicine
▪ Director of Cardiac Rehab
▪ Phoenix Top Doc 2011
▪ Top Holistic MD 2012,14-17
Prescriptions Filled in the U.S., 2014 (Generic)
9/16/18
ALLHAT Trial-18% More People
Died in the Statin Group
JAMA Intern Med. 2017;177(7):955-965. doi:10.1001/jamainternmed.2017.1442
One Million Stents Per Year½ Million Bypass Surgeries
Leaky Gut Syndrome
Immune System Activation Inflammation/Oxidative Stress
Leaky
Heart
Syndrome
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458511/figure/F1/
Zonulin controls the tight junction
Zonulin Levels Are Higher in Patients with Coronary Artery Disease
https://www.ncbi.nlm.nih.gov/pubmed/28069576
Zonulin levels are higher in people with:
AI▪ Celiac▪ IBD▪ RA▪ SLE▪ Type 1 DM▪ AS
Cancer▪ Brain▪ Breast▪ Lung adeno CA▪ Ovarian▪ Pancreatic
Nervous ▪ Demyelination
(MS and CIDP)▪ Psych disorders
Fasano, A. Physiol Rev. January 2011
https://www.ncbi.nlm.nih.gov/pubmed/28285651
Leaky Gut Linked to Metabolic Syndrome and Inflammation
https://www.ncbi.nlm.nih.gov/pubmed/28282855
Zonulin and:▪ Obesity▪ Hypertension▪ Elevated blood sugar▪ Dyslipidemia
The higher the LPS…the higher the heart attack risk
https://www.ncbi.nlm.nih.gov/pubmed/17601541
Lipopolysaccharides (LPS)
- Increase coagulation- Activate compliment- Activate TLR present on cardiac myocytes- Decrease contractility- Decrease vascular responsiveness- Induce cell apoptosis
https://www.ncbi.nlm.nih.gov/pubmed/20592272
Anti-actin Antibodies
Anti-actin Antibodies
Leaky Gut is Linked to Heart Failure
Leaky Gut and Parkinson’s Disease
Leaky Gut is Leaky Brain
Intestinal Permeability and Autism Spectrum
26% of ASD group
2% of control group
Leaky Gut and Cancer
Prevent the Leaky Gut
Treat the Leaky Gut
Quality waterSpicesFermented foodsOrgans
Paleo Versus the Dutch Diet
Intestinal Permeability By Lactulose: Mannitol Ratio
After two weeks on the recommended diet, Paleo IP improved by 21%, while the Dutch diet led to a 27% INCREASED IP
Gluten Free Improves Leaky Gut
AND ASD Symptoms
Gluten-free Diet Resolves
Neurologic Symptoms in
Celiac and Non-Celiac
Patients
Whey Protein and Leaky Gut
Metals Destroy The BBB
Alcohol and Leaky Gut
Pharma and OTC and Leaky Gut??????????
Vitamin D and the Leaky Gut
Decreased Melatonin and Leaky Gut
Sleep Apnea and Leaky Gut
Stress and the Leaky Gut
https://www.ncbi.nlm.nih.gov/pubmed/26528128
Leaky Teeth?- See Your Holistic Dentist
Pubmed.gov- 151 studies
The Gift of Chiropractic
Evidence Based Supplements for Leaky Gut
1) Multivitamin2) Digestive enzymes3) Probiotics and prebiotics4) Omega DHA5) Vitamin D6) Berberine7) Butyrate8) Curcumin9) Whey protein 10)Glutamine11)Immunoglobulins12)Lactoferrin
Berberine
Vitamin D Supplementation and Leaky Gut
Butyric acid
Butyrate Lowers
Inflammation
Butyrate Reduces Plaque
Omega-3 Increases butyrate-producing Bacteria
Chlorogenic acid (coffee and honeysuckle)- https://www.ncbi.nlm.nih.gov/pubmed/30263265, https://www.ncbi.nlm.nih.gov/pubmed/26824685
Curcumin- https://www.ncbi.nlm.nih.gov/pubmed/25251395
Whey protein- https://www.ncbi.nlm.nih.gov/pubmed/26810899,https://www.ncbi.nlm.nih.gov/pubmed/25012977
Lactoferrin- https://www.ncbi.nlm.nih.gov/pubmed/26810899
Immunoglobulins- https://www.ncbi.nlm.nih.gov/pubmed/26068582
TheHealthyHeartShow.com