Leaky Heart Syndrome

Jack Wolfson DO, FACCTheDrsWolfson.com

▪ D.O. 1996- Midwestern Univ.

▪ Internal Medicine 96-99

▪ Cardiology 1999-2002

▪ Chief fellow

▪ Senior partner of a large cardiology

group, 2002-2012

▪ Chairman of Dept. of Medicine

▪ Director of Cardiac Rehab

▪ Phoenix Top Doc 2011

▪ Top Holistic MD 2012,14-17

Prescriptions Filled in the U.S., 2014 (Generic)

9/16/18

ALLHAT Trial-18% More People

Died in the Statin Group

JAMA Intern Med. 2017;177(7):955-965. doi:10.1001/jamainternmed.2017.1442

One Million Stents Per Year½ Million Bypass Surgeries

Leaky Gut Syndrome

Immune System Activation Inflammation/Oxidative Stress

Leaky

Heart

Syndrome

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458511/figure/F1/

Zonulin controls the tight junction

Zonulin Levels Are Higher in Patients with Coronary Artery Disease

https://www.ncbi.nlm.nih.gov/pubmed/28069576

Zonulin levels are higher in people with:

AI▪ Celiac▪ IBD▪ RA▪ SLE▪ Type 1 DM▪ AS

Cancer▪ Brain▪ Breast▪ Lung adeno CA▪ Ovarian▪ Pancreatic

Nervous ▪ Demyelination

(MS and CIDP)▪ Psych disorders

Fasano, A. Physiol Rev. January 2011

https://www.ncbi.nlm.nih.gov/pubmed/28285651

Leaky Gut Linked to Metabolic Syndrome and Inflammation

https://www.ncbi.nlm.nih.gov/pubmed/28282855

Zonulin and:▪ Obesity▪ Hypertension▪ Elevated blood sugar▪ Dyslipidemia

The higher the LPS…the higher the heart attack risk

https://www.ncbi.nlm.nih.gov/pubmed/17601541

Lipopolysaccharides (LPS)

- Increase coagulation- Activate compliment- Activate TLR present on cardiac myocytes- Decrease contractility- Decrease vascular responsiveness- Induce cell apoptosis

https://www.ncbi.nlm.nih.gov/pubmed/20592272

Anti-actin Antibodies

Anti-actin Antibodies

Leaky Gut is Linked to Heart Failure

Leaky Gut and Parkinson’s Disease

Leaky Gut is Leaky Brain

Intestinal Permeability and Autism Spectrum

26% of ASD group

2% of control group

Leaky Gut and Cancer

Prevent the Leaky Gut

Treat the Leaky Gut

Quality waterSpicesFermented foodsOrgans

Paleo Versus the Dutch Diet

Intestinal Permeability By Lactulose: Mannitol Ratio

After two weeks on the recommended diet, Paleo IP improved by 21%, while the Dutch diet led to a 27% INCREASED IP

Gluten Free Improves Leaky Gut

AND ASD Symptoms

Gluten-free Diet Resolves

Neurologic Symptoms in

Celiac and Non-Celiac

Patients

Whey Protein and Leaky Gut

Metals Destroy The BBB

Alcohol and Leaky Gut

Pharma and OTC and Leaky Gut??????????

Vitamin D and the Leaky Gut

Decreased Melatonin and Leaky Gut

Sleep Apnea and Leaky Gut

Stress and the Leaky Gut

https://www.ncbi.nlm.nih.gov/pubmed/26528128

Leaky Teeth?- See Your Holistic Dentist

Pubmed.gov- 151 studies

The Gift of Chiropractic

Evidence Based Supplements for Leaky Gut

1) Multivitamin2) Digestive enzymes3) Probiotics and prebiotics4) Omega DHA5) Vitamin D6) Berberine7) Butyrate8) Curcumin9) Whey protein 10)Glutamine11)Immunoglobulins12)Lactoferrin

Berberine

Vitamin D Supplementation and Leaky Gut

Butyric acid

Butyrate Lowers

Inflammation

Butyrate Reduces Plaque

Omega-3 Increases butyrate-producing Bacteria

Chlorogenic acid (coffee and honeysuckle)- https://www.ncbi.nlm.nih.gov/pubmed/30263265, https://www.ncbi.nlm.nih.gov/pubmed/26824685

Curcumin- https://www.ncbi.nlm.nih.gov/pubmed/25251395

Whey protein- https://www.ncbi.nlm.nih.gov/pubmed/26810899,https://www.ncbi.nlm.nih.gov/pubmed/25012977

Lactoferrin- https://www.ncbi.nlm.nih.gov/pubmed/26810899

Immunoglobulins- https://www.ncbi.nlm.nih.gov/pubmed/26068582

TheHealthyHeartShow.com